Staff Profiles

Dr Manus Biggs

Ph.D

Biography

Peer Reviewed Journals

	Year	Publication
	(2016)	'2D imprinted substrates and 3D electrospun scaffolds revolutionize biomedicine' Manus Biggs, Abhay Pandit, Dimitrios I Zeugolis (2016) '2D imprinted substrates and 3D electrospun scaffolds revolutionize biomedicine'. Nanomedicine, 11 (9):989-992 [Details]
	(2016)	'An insight into morphometric descriptors of cell shape that pertain to regenerative medicine' oana Lobo, Eugene Yong‐Shun See, Manus Biggs, Abhay Pandit (2016) 'An insight into morphometric descriptors of cell shape that pertain to regenerative medicine'. Journal Of Tissue Engineering And Regenerative Medicine, 10 (7):539-553 [Details]
	(2016)	'Responsive biomaterials: advances in materials based on shape‐memory polymers' John G Hardy, Matteo Palma, Shalom J Wind, Manus J Biggs (2016) 'Responsive biomaterials: advances in materials based on shape‐memory polymers'. Advanced Materials, 28 (27):5717-5724 [Details]
	(2016)	'Polyhydroxyalkanoate/carbon nanotube nanocomposites: flexible electrically conducting elastomers for neural applications' Catalina Vallejo-Giraldo, Eugenia Pugliese, Aitor Larrañaga, Marc A Fernandez-Yague, James J Britton, Alexandre Trotier, Ghazal Tadayyon, Adriona Kelly, Ilaria Rago, Jose-Ramon Sarasua, Eilís Dowd, Leo R Quinlan, Abhay Pandit, Manus JP Biggs (2016) 'Polyhydroxyalkanoate/carbon nanotube nanocomposites: flexible electrically conducting elastomers for neural applications'. Nanomedicine (London, England), 11 (19):2547-2563 [Details]
	(2016)	'Effects of isothermal crystallization on the mechanical properties of a elastomeric medium chain length polyhydroxyalkanoate' A Larrañaga, F Pompanon, N Gruffat, T Palomares, A Alonso-Varona, A Larrañaga Varga, MA Fernandez-Yague, MJP Biggs, JR Sarasua (2016) 'Effects of isothermal crystallization on the mechanical properties of a elastomeric medium chain length polyhydroxyalkanoate'. European Polymer Journal, 85 :401-410 [Details]
	(2017)	'Effect of different stages of deformation on the microstructure evolution of Ti-rich NiTi shape memory alloy' Ghazal Tadayyon, Yina Guo, Mohammad Mazinani, Seyed Mojtaba Zebarjad, Peter Tiernan, Syed AM Tofail, Manus JP Biggs (2017) 'Effect of different stages of deformation on the microstructure evolution of Ti-rich NiTi shape memory alloy'. Materials Characterization, 125 :51-66 [Details]
	(2017)	'Biomimetic bioactive biomaterials: the next generation of implantable devices' Dimitrios Tsiapalis, Andrea De Pieri, Manus Biggs, Abhay Pandit, Dimitrios I Zeugolis (2017) 'Biomimetic bioactive biomaterials: the next generation of implantable devices'. ACS Biomaterials Science & Engineering, 302 (7):1172-1174 [Details]
	(2017)	'Stimulation of 3D osteogenesis by mesenchymal stem cells using a nanovibrational bioreactor' Penelope M Tsimbouri, Peter G Childs, Gabriel D Pemberton, Jingli Yang, Vineetha Jayawarna, Wich Orapiriyakul, Karl Burgess, Cristina González-García, Gavin Blackburn, Dilip Thomas, Catalina Vallejo-Giraldo, Manus JP Biggs, Adam SG Curtis, Manuel Salmerón-Sánchez, Stuart Reid, Matthew J Dalby (2017) 'Stimulation of 3D osteogenesis by mesenchymal stem cells using a nanovibrational bioreactor'. Nature Biomedical Engineering, 1 (9):758-770 [Details]
	(2017)	'The functional response of mesenchymal stem cells to electron‐beam patterned elastomeric surfaces presenting micrometer to nanoscale heterogeneous rigidity' Manus JP Biggs, Marc Fernandez, Dilip Thomas, Ryan Cooper, Matteo Palma, Jinyu Liao, Teresa Fazio, Carl Dahlberg, Helen Wheadon, Anuradha Pallipurath, Abhay Pandit, Jeffrey Kysar, Shalom J Wind (2017) 'The functional response of mesenchymal stem cells to electron‐beam patterned elastomeric surfaces presenting micrometer to nanoscale heterogeneous rigidity'. Advanced Materials, 29 (39) [Details]
	(2017)	'Foreword to special issue on two-dimensional biomaterials in regenerative medicine' Manus Biggs, Dimitrios Zeugolis, Abhay Pandit (2017) 'Foreword to special issue on two-dimensional biomaterials in regenerative medicine'. Nanomedicine: Nanotechnology, Biology, And Medicine, 14 (7):2351-2353 [Details]
	(2017)	'Foreword to special issue on two-dimensional biomaterials in regenerative medicine' Manus Biggs, Dimitrios Zeugolis, Abhay Pandit (2017) 'Foreword to special issue on two-dimensional biomaterials in regenerative medicine'. Nanomedicine: Nanotechnology, Biology, And Medicine, 14 (7):2351-2353 [Details]
	(2017)	'Stable tissue-mimicking materials and an anatomically realistic, adjustable head phantom for electrical impedance tomography' Barry McDermott, Brian McGinley, Katarzyna Krukiewicz, Brendan Divilly, Marggie Jones, Manus Biggs, Martin O’Halloran, Emily Porter (2017) 'Stable tissue-mimicking materials and an anatomically realistic, adjustable head phantom for electrical impedance tomography'. Biomedical Physics & Engineering Express, 4 (1) [Details]
	(2018)	'Advanced Functional Materials Solutions to Engineering the Neural Interface' Abhay Pandit, Manus Biggs (2018) 'Advanced Functional Materials Solutions to Engineering the Neural Interface'. Advanced Functional Materials, 28 (12) [Details]
	(2018)	'Neural Interface Materials: Preparation of Cytocompatible ITO Neuroelectrodes with Enhanced Electrochemical Characteristics Using a Facile Anodic Oxidation Process' Catalina Vallejo‐Giraldo, Niccolò Paolo Pampaloni, Anuradha R Pallipurath, Parvaneh Mokarian‐Tabari, John O'Connell, Justin D Holmes, Alexandre Trotier, Katarzyna Krukiewicz, Gemma Orpella‐Aceret, Eugenia Pugliese, Laura Ballerini, Michelle Kilcoyne, Eilís Dowd, Leo R Quinlan, Abhay Pandit, Paul Kavanagh, Manus Jonathan Paul Biggs (2018) 'Neural Interface Materials: Preparation of Cytocompatible ITO Neuroelectrodes with Enhanced Electrochemical Characteristics Using a Facile Anodic Oxidation Process'. Advanced Functional Materials, 28 (12) [Details]
	(2018)	'Nanocellulose reinforced gellan-gum hydrogels as potential biological substitutes for annulus fibrosus tissue regeneration' Diana R Pereira, Joana Silva-Correia, Joaquim M Oliveira, Rui L Reis, Abhay Pandit, Manus J Biggs (2018) 'Nanocellulose reinforced gellan-gum hydrogels as potential biological substitutes for annulus fibrosus tissue regeneration'. Nanomedicine, 14 (3):897-908 [Details]
	(2018)	'Attenuated Glial Reactivity on Topographically Functionalized Poly(3,4‐Ethylenedioxythiophene):P‐Toluene Sulfonate (PEDOT:PTS) Neuroelectrodes Fabricated by Microimprint Lithography' Catalina Vallejo‐Giraldo, Katarzyna Krukiewicz, Ivo Calaresu, Jingyuan Zhu, Matteo Palma, Marc Fernandez‐Yague, BenjaminW McDowell, Nathalia Peixoto, Nazar Farid, Gerard O'Connor, Laura Ballerini, Abhay Pandit, Manus Jonathan Paul Biggs (2018) 'Attenuated Glial Reactivity on Topographically Functionalized Poly(3,4‐Ethylenedioxythiophene):P‐Toluene Sulfonate (PEDOT:PTS) Neuroelectrodes Fabricated by Microimprint Lithography'. Small, 14 (28) [Details]
	(2020)	'In vitro analysis of a physiological strain sensor formulated from a PEDOT:PSS functionalized carbon nanotube-poly(glycerol sebacate urethane) composite' Ghazal Tadayyon, Katarzyna Krukiewicz, James Britton, Aitor Larrañaga, Catalina Vallejo-Giraldo, Marc Fernandez-Yague, Yina Guo, Lu Li, Anup Poudel, Manus J.P Biggs (2020) 'In vitro analysis of a physiological strain sensor formulated from a PEDOT:PSS functionalized carbon nanotube-poly(glycerol sebacate urethane) composite'. Advanced Materials Technologies, [Details]
	(2019)	'PEDOT: PSS interfaces stabilised using a PEGylated crosslinker yield improved conductivity and biocompatibility' Matteo Solazzo, Katarzyna Krukiewicz, Ainur Zhussupbekova, Karsten Fleischer, Manus J Biggs, Michael G Monaghan (2019) 'PEDOT: PSS interfaces stabilised using a PEGylated crosslinker yield improved conductivity and biocompatibility'. Journal Of Materials Chemistry B, 7 (31):4811-4820 [Details]
	(2019)	'Boron nitride nanotube addition enhances the crystallinity and cytocompatibility of PVDF-TrFE' Anup Poudel, Marc A Fernandez, Syed AM Tofail, Manus JP Biggs (2019) 'Boron nitride nanotube addition enhances the crystallinity and cytocompatibility of PVDF-TrFE'. Frontiers In Chemistry, 7 [Details]
	(2019)	'Analysis of a poly (ε-decalactone)/silver nanowire composite as an electrically conducting neural interface biomaterial' Katarzyna Krukiewicz, Jorge Fernandez, Małgorzata Skorupa, Daria Więcławska, Anup Poudel, Jose-Ramon Sarasua, Leo R Quinlan, Manus JP Biggs (2019) 'Analysis of a poly (ε-decalactone)/silver nanowire composite as an electrically conducting neural interface biomaterial'. BMC Biomedical Engineering, 1 (1):106616-12 [Details]
	(2020)	'Low resistance, highly corrugated structures based on poly (3, 4-ethylenedioxythiophene) doped with a D-glucopyranoside-derived ionic liquid' Katarzyna Krukiewicz, Dominika Kobus, Roman Turczyn, Karol Erfurt, Anna Chrobok, Manus JP Biggs (2020) 'Low resistance, highly corrugated structures based on poly (3, 4-ethylenedioxythiophene) doped with a D-glucopyranoside-derived ionic liquid'. Electrochemistry Communications, 110 [Details]
	(2020)	'Nanovibrational Stimulation of Mesenchymal Stem Cells Induces Therapeutic Reactive Oxygen Species and Inflammation for Three-Dimensional Bone Tissue Engineer' Wich Orapiriyakul, Monica P. Tsimbouri, Peter Childs, Paul Campsie, Julia Wells, Marc A. Fernandez-Yague, Karl Burgess, K. Elizabeth Tanner, Manlio Tassieri, Dominic Meek, Massimo Vassalli, Manus J. P. Biggs, Manuel Salmeron-Sanchez, Richard O. C. Oreffo, Stuart Reid, and Matthew J. Dalby* (2020) 'Nanovibrational Stimulation of Mesenchymal Stem Cells Induces Therapeutic Reactive Oxygen Species and Inflammation for Three-Dimensional Bone Tissue Engineer'. ACS Nano, [DOI] [Details]
	(2020)	'Benefits of Polydopamine as Particle/Matrix Interface in Polylactide/PD-BaSO4 Scaffolds' Naroa Sadaba, Aitor Larrañaga, Gemma Orpella-Aceret, Ana F Bettencourt, Victor Martin, Manus Biggs, Isabel AC Ribeiro, Jone M Ugartemendia, Jose-Ramon Sarasua, Ester Zuza (2020) 'Benefits of Polydopamine as Particle/Matrix Interface in Polylactide/PD-BaSO4 Scaffolds'. International Journal Of Molecular Sciences, 21 (15) [Details]
	(2020)	'Laser-Induced Periodic Surface Structure Enhances Neuroelectrode Charge Transfer Capabilities and Modulates Astrocyte Function' Adriona Kelly, Nazar Farid, Katarzyna Krukiewicz, Nicole Belisle, John Groarke, Elaine M Waters, Alexandre Trotier, Fathima Laffir, Michelle Kilcoyne, Gerard M O’Connor, Manus J Biggs (2020) 'Laser-Induced Periodic Surface Structure Enhances Neuroelectrode Charge Transfer Capabilities and Modulates Astrocyte Function'. ACS Biomaterials Science & Engineering, 6 (3):1449-1461 [Details]
	(2019)	'Enhanced osteoconductivity on electrically charged titanium implants treated by physicochemical surface modifications methods' Fernandez-Yague, M;Antonanzas, RP;Roa, JJ;Biggs, M;Gil, FJ;Pegueroles, M (2019) 'Enhanced osteoconductivity on electrically charged titanium implants treated by physicochemical surface modifications methods'. Nanomedicine-Nanotechnology Biology And Medicine, 18 :1-10 [DOI] [Details]
	(2019)	'Enhanced osteoconductivity on electrically charged titanium implants treated by physicochemical surface modifications methods' Fernandez-Yague, M,Antonanzas, RP,Roa, JJ,Biggs, M,Gil, FJ,Pegueroles, M (2019) 'Enhanced osteoconductivity on electrically charged titanium implants treated by physicochemical surface modifications methods'. Nanomedicine-Nanotechnology Biology And Medicine, 18 :1-10 [DOI] [Details]
	(2015)	'Data on in vitro and in vivo cell orientation on substrates with different topographies' English, A;Azeem, A;Spanoudes, K;Jones, E;Tripathi, B;Basu, N;McNamara, K;Tofail, SAM;Rooney, N;Riley, G;O'Riordan, A;Cross, G;Hutmacher, D;Biggs, M;Pandit, A;Zeugolis, DI (2015) 'Data on in vitro and in vivo cell orientation on substrates with different topographies'. Data In Brief, 5 :379-382 [DOI] [Details]
	(2018)	'Smart Nanoparticles for Biomedicine Foreword' Loffredo, A;Biggs, M (2018) 'Smart Nanoparticles for Biomedicine Foreword'. Smart Nanoparticles For Biomedicine, [Details]
	(2018)	'Fractal form PEDOT/Au assemblies as thin-film neural interface materials' Katarzyna Krukiewicz, Magdalena Chudy, Catalina Vallejo-Giraldo, Małgorzata Skorupa, Daria Więcławska, Manus Biggs (2018) 'Fractal form PEDOT/Au assemblies as thin-film neural interface materials'. Biomedical Materials, 13 [DOI] [ARAN Link] [Details]
	(2019)	'Electrodeposited poly(3,4-ethylenedioxypyrrole) films as neural interfaces: cytocompatibility and electrochemical studies' Katarzyna Krukiewicz, Agnieszka Kowalik, Dominika Czerwinska-Glowka, Manus J.P. Biggs (2019) 'Electrodeposited poly(3,4-ethylenedioxypyrrole) films as neural interfaces: cytocompatibility and electrochemical studies'. Electrochimica Acta, 302 :21-30 [DOI] [Details]
	(2019)	'Electrodeposited poly(3,4-ethylenedioxypyrrole) films as neural interfaces: cytocompatibility and electrochemical studies' Katarzyna Krukiewicz, Agnieszka Kowalik, Dominika Czerwińska-Główka, Manus J.P. Biggs (2019) 'Electrodeposited poly(3,4-ethylenedioxypyrrole) films as neural interfaces: cytocompatibility and electrochemical studies'. Electrochimica Acta, [DOI] [ARAN Link] [Details]
	(2018)	'Chirality-Sorted Carbon Nanotube Films as High Capacity Electrode Materials' Krukiewicz K, Maciej Krzywiecki, Biggs MJ, Janas D. (2018) 'Chirality-Sorted Carbon Nanotube Films as High Capacity Electrode Materials'. Rsc Advances, 8 (53):30600-30609 [DOI] [ARAN Link] [Details]
	(2017)	'In Vitro Enzymatic Degradation of Tissue Grafts and Collagen Biomaterials by Matrix Metalloproteinases: Improving the Collagenase Assay' Helling, AL,Tsekoura, EK,Biggs, M,Bayon, Y,Pandit, A,Zeugolis, DI (2017) 'In Vitro Enzymatic Degradation of Tissue Grafts and Collagen Biomaterials by Matrix Metalloproteinases: Improving the Collagenase Assay'. ACS Biomaterials Science & Engineering, 3 :1922-1932 [DOI] [Details]
	(2018)	'Stable tissue-mimicking materials and an anatomically realistic, adjustable head phantom for electrical impedance tomography' McDermott, B;McGinley, B;Krukiewicz, K;Divilly, B;Jones, M;Biggs, M;O'Halloran, M;Porter, E (2018) 'Stable tissue-mimicking materials and an anatomically realistic, adjustable head phantom for electrical impedance tomography'. Biomedical Physics & Engineering Express, 4 [DOI] [ARAN Link] [Details]
	(2018)	'Stable tissue-mimicking materials and an anatomically realistic, adjustable head phantom for electrical impedance tomography' McDermott, B,McGinley, B,Krukiewicz, K,Divilly, B,Jones, M,Biggs, M,O'Halloran, M,Porter, E (2018) 'Stable tissue-mimicking materials and an anatomically realistic, adjustable head phantom for electrical impedance tomography'. Biomedical Physics & Engineering Express, 4 [DOI] [Details]
	(2015)	'Sensing the Difference: The Influence of Anisotropic Surfaces on Cell Behavior' Ballester-Beltrán J, Biggs M, Dalby MJ, Salmeron-Sanchez M, and Leal-Egaña A. (2015) 'Sensing the Difference: The Influence of Anisotropic Surfaces on Cell Behavior'. Frontiers In Bioscience, 2 (39) [DOI] [Details]
	(2015)	'An academic, clinical and industrial update on electro-spun, additive manufactured and imprinted medical devices' Ryan CNM, Fuller KP, Larrañaga A, Biggs M, Bayon Y, Sarasua JR, Pandit A, Zeugolis D. (2015) 'An academic, clinical and industrial update on electro-spun, additive manufactured and imprinted medical devices'. Expert Review Of Medical Devices, [Details]
	(2015)	'Substrate topography: A valuable in vitro tool, but a clinical red herring for in vivo tenogenesis' English A, Azeem A, Biggs M, Jones E, Tripathi B, Basu N, Rooney N, Riley G, O'Riordan A, Cross G, Hutmacher D, Pandit A, Zeugolis DI, (2015) 'Substrate topography: A valuable in vitro tool, but a clinical red herring for in vivo tenogenesis'. Acta Biomaterialia, [Details]
	(2015)	'The influence of anisotropic nano- to micro-topography on in vitro and in vivo osteogenesis' Azeem, A,English, A,Kumar, P,Satyam, A,Biggs, M,Jones, E,Tripathi, B,Basu, N,Henkel, J,Vaquette, C,Rooney, N,Riley, G,O'Riordan, A,Cross, G,Ivanovski, S,Hutmacher, D,Pandit, A,Zeugolis, D (2015) 'The influence of anisotropic nano- to micro-topography on in vitro and in vivo osteogenesis'. Nanomedicine, 10 :693-711 [DOI] [Details]
	(2015)	'Nanoscale neuroelectrode modification through self-assembly of block copolymers' Mokarian-Tabari P, Vallejo-Giraldo C, Fernandez-Yague M, Cummins C, Morris MA, Biggs M.J. (2015) 'Nanoscale neuroelectrode modification through self-assembly of block copolymers'. Journal Of Materials Science: Materials In Medicine, 26 (120):1-5 [Details]
	(2015)	'The influence of anisotropic nano- to micro-topography on in vitro and in vivo osteogenesis' Azeem A, English E, Biggs M, Jones E, Tripathi B, Henkel J, Vaquette C, Rooney N, Riley G, O’Riordan A, Cross G, Hutmacher D, Pandit A, Zeugolis D (2015) 'The influence of anisotropic nano- to micro-topography on in vitro and in vivo osteogenesis'. Nanomedicine (London, England), 10 (5):693-711 [Details]
	(2015)	'Special Focus on Nanoscale Regeneration' Dalby MJ, Biggs MJ (2015) 'Special Focus on Nanoscale Regeneration'. Nanomedicine (London, England), 10 (5):677-680 [Details]
	(2014)	'Biofunctionalisation of electrically conducting polymers' Vallejo-Giraldo C, Kelly A, Biggs MJ (2014) 'Biofunctionalisation of electrically conducting polymers'. Drug Discovery Today, [Details]
	(2014)	'Osteogenic Lineage Restriction by Osteoprogenitors Cultured on Nanometric Grooved Surfaces – the Role of Focal Adhesion Maturation' Cassidy JW, Roberts JN, Smith C, Robertson M, White K, Biggs MJ, Oreffo RO, Dalby MJ (2014) 'Osteogenic Lineage Restriction by Osteoprogenitors Cultured on Nanometric Grooved Surfaces – the Role of Focal Adhesion Maturation'. Acta Biomateriala, [Details]
	(2014)	'Cellular response to ferroelectric PVDF-TrFE surfaces of varying polymer concentration' Biggs MJ, Parisi-Capdevila E, Valejo-Giraldo C, Wind SJ (2014) 'Cellular response to ferroelectric PVDF-TrFE surfaces of varying polymer concentration'. Journal Of Biomedical Nanotechnology, [Details]
	(2014)	'Biomimetic Approaches in Bone Tissue Engineering: Integrating Biological and Physicomechanical Strategies' Fernandez-Yague MA, Abbah SA, McNamara L, Zeugolis DI, Pandit A, * Biggs MJ (2014) 'Biomimetic Approaches in Bone Tissue Engineering: Integrating Biological and Physicomechanical Strategies'. Advanced Drug Delivery Reviews, [DOI] [Details]
	(2014)	'An insight into morphometric descriptors of cell shape that pertain to regenerative medicine' Lobo J, See E, Biggs MJ, Pandit A. (2014) 'An insight into morphometric descriptors of cell shape that pertain to regenerative medicine'. Journal Of Tissue Engineering And Regenerative Medicine, [DOI] [Details]
	(2014)	'The past, present and future in scaffold-based tendon treatments' Lomas, A. J. Ryan, C. N. Sorushanova, A. Shologu, N. Sideri, A. I. Tsioli, V. Fthenakis, G. C. Tzora, A. Skoufos, I. Quinlan, L. R. O'Laighin, G. Mullen, A. M. Kelly, J. L. Kearns, S. Biggs, M. Pandit, A. Zeugolis, D. I. (2014) 'The past, present and future in scaffold-based tendon treatments'. Advanced Drug Delivery Reviews, [Details]
	(2014)	'Diatoms: A Biotemplating Approach to Fabricating Drug Delivery Reservoirs' Chao J, Biggs MJ, Pandit A. (2014) 'Diatoms: A Biotemplating Approach to Fabricating Drug Delivery Reservoirs'. Expert Opinion On Drug Delivery, 11 (11):1687-1695 [Details]
	(2012)	'The role of microtopography in cellular mechanotransduction' McNamara LE, Burchmore R, Riehle MO, Herzyk P, Tsimbouri PM, Biggs MJP, Wilkinson CDW, Curtis ASG, Dalby MJ. (2012) 'The role of microtopography in cellular mechanotransduction'. Biomaterials, [Details]
	(2011)	'High resolution imaging of the immunological synapse and TCR microclustering through micro fabricated substrates’' Biggs MJ, Gondarenko A, Milone MC, Santos L, Wind SJ (2011) 'High resolution imaging of the immunological synapse and TCR microclustering through micro fabricated substrates’'. Journal Of The Royal Society Interface, [Details]
	(2010)	'Focal adhesions in osteoneogenesis' Biggs MJ, Dalby MJ (2010) 'Focal adhesions in osteoneogenesis'. Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine, [Details]
	(2010)	'Nanotopographical modification: a regulator of cellular function through focal adhesions' Biggs MJ, Dalby MJ. (2010) 'Nanotopographical modification: a regulator of cellular function through focal adhesions'. Nanomedicine: Nanotechnology, Biology, And Medicine, [Details]
	(2010)	'Nanotopographical control of stem cell differentiation' McNamara L, McMurray RJ, Biggs MJ, Kantawong F, Oreffo ROC, Dalby MJ (2010) 'Nanotopographical control of stem cell differentiation'. Tissue Engineering, [Details]
	(2009)	'The use of nanoscale topography to modulate the dynamics of adhesion formation in primary osteoblasts and ERK/MAPK signalling in STRO-1+ enriched skeletal stem cells' Biggs MJ, Richards RG, Gadegaard N, Wilkinson CD, Oreffo RO, Dalby MJ. (2009) 'The use of nanoscale topography to modulate the dynamics of adhesion formation in primary osteoblasts and ERK/MAPK signalling in STRO-1+ enriched skeletal stem cells'. Biomaterials, [Details]
	(2009)	'Interactions with nanoscale topography: Adhesion quantification and signal transduction in cells of osteogenic and multipotent lineage' Biggs MJ, Richards RG, Gadegaard N, McMurray RJ, Affrossman S, Wilkinson CD, Oreffo RO, Dalby MJ. (2009) 'Interactions with nanoscale topography: Adhesion quantification and signal transduction in cells of osteogenic and multipotent lineage'. J. Biomedical Materials Research- Part A, [Details]
	(2008)	'Focal adhesion interactions with nanostructures: A novel method for immuno-SEM labelling of focal adhesions in S-phase cells' Biggs MJ, Richards RG, Wilkinson CD, Dalby MJ. (2008) 'Focal adhesion interactions with nanostructures: A novel method for immuno-SEM labelling of focal adhesions in S-phase cells'. Journal Of Microscopy-Oxford, [Details]
	(2008)	'Adhesion formation of primary human osteoblasts and the functional response of mesenchymal stem cells to 330 nm deep microgrooves' Biggs MJ, Richards RG, Gadegaard N, Wilkinson CD, Oreffo ROC, Affrossman S, Dalby MJ. (2008) 'Adhesion formation of primary human osteoblasts and the functional response of mesenchymal stem cells to 330 nm deep microgrooves'. Journal Of The Royal Society Interface, [Details]
	(2007)	'The effects of nanoscale pits on primary human osteoblast adhesion formation and cellular spreading' Biggs MJ, Richards RG, Gadegaard N, Wilkinson CD, Dalby MJ (2007) 'The effects of nanoscale pits on primary human osteoblast adhesion formation and cellular spreading'. Journal Of Material Science: Materials In Medicine, [Details]
	(2006)	'Nanotopographical stimulation of mechanotransduction and changes in interphase centromere positioning' Dalby MJ, Biggs MJ, Gadegaard N, Kalna G, Wilkinson CD, Curtis AS (2006) 'Nanotopographical stimulation of mechanotransduction and changes in interphase centromere positioning'. Journal Of Cellular Biochemistry, [Details]
	(2006)	'Regulation of implant surface cell adhesion: characterization and quantification of S-phase primary osteoblast adhesions on biomimetic nanoscale substrates' Biggs MJ, Richards RG, Gadegaard N, Wilkinson CD, Dalby MJ (2006) 'Regulation of implant surface cell adhesion: characterization and quantification of S-phase primary osteoblast adhesions on biomimetic nanoscale substrates'. Journal Of Orthopaedic Research, [Details]

Book Chapters

	Year	Publication
	(2016)	'Biological activity on piezoelectric PVDF' Marc A Fernandez-Yague, Catalina Vallejo-Giraldo, Gemma Orpella Aceret, Abhay Pandit, Manus J Biggs (2016) 'Biological activity on piezoelectric PVDF' In: Electrically Active Materials for Medical Devices. USA: World Scientific. [DOI] [Details]
	(2017)	'Engineering the Neural Interface' A Kelly, L Ballerini, M Lowery, M Biggs (2017) 'Engineering the Neural Interface' In: Neural Engineering. USA: Elsevier. [Details]
	(2017)	'Xenogenic Tissues and Biomaterials for the Skeletal System' V Graceffa, Z Wu, D Gaspar, K Spanoudes, ILM Isa, M Biggs, AM Mullen, A Pandit, DI Zeugolis (2017) 'Xenogenic Tissues and Biomaterials for the Skeletal System' In: Comprehensive Biomaterials. USA: Elsevier. [Details]
	(2018)	'Cell Carriers for Bone and Cartilage Repair In Vivo' Thomas, D., Biggs, M., O’Brien, T. and Pandit, A. (2018) 'Cell Carriers for Bone and Cartilage Repair In Vivo' In: Biomaterials for Cell Delivery: Vehicles in Regenerative Medicine. London: CRC/Press Taylor & Francis Group. [DOI] [Details]
	(2015)	'On the use of stereology in tissue scaffolds' Dockery, P & Biggs, M. (2015) 'On the use of stereology in tissue scaffolds' In: Characterisation and design of Tissue Scaffolds. UK: Wiley. [Details]
	(2015)	'Tendon regeneration: Understanding tissue physiology and development to engineer functional substitutes' Lomas, A., English, A., Biggs, M., Pandit, A., Zeugolis, D.I. (2015) 'Tendon regeneration: Understanding tissue physiology and development to engineer functional substitutes' In: Engineering anisotropic 2D and 3D structures for tendon repair and regeneration. UK: Elsevier Science. [Details]
	(2013)	'The Modulation of Skeletal Stem Cell Function Through Nanoscale Topography' Biggs MJ, McNamara L. (2013) 'The Modulation of Skeletal Stem Cell Function Through Nanoscale Topography' In: Stem Cells & Bone Tissue. Boca Raton, FL: CRC Press. [Details]
	(2012)	'Cellular response to nanoscale features' Biggs MJ, Dalby MJ, Wind SJ (2012) 'Cellular response to nanoscale features' In: The Nanobiotechnology Handbook. Boca Raton, FL: CRC Press. [Details]
	(2011)	'Using immuno-scanning electron microscopy for simultaneous observation of cell adhesion interaction at the nano/microscale in S-phase cells' Biggs MJ, Richards RG, Dalby (2011) 'Using immuno-scanning electron microscopy for simultaneous observation of cell adhesion interaction at the nano/microscale in S-phase cells' In: Methods in Molecular Biology 3D Cell Culture. New York, NY 10013-1578: Humana Press. [Details]

Conference Publications

	Year	Publication
	(2016)	*IRISH JOURNAL OF MEDICAL SCIENCE* C Comte, MA Fernandez-Yague, L Quinlan, A Pandit, MJP Biggs (2016) Fabrication of Piezoelectric PVDF TrFE Nanocomposite Scaffolds for Bone-Tissue Engineering IRISH JOURNAL OF MEDICAL SCIENCE [Details]
	(2016)	*RISH JOURNAL OF MEDICAL SCIENCE* C Vallejo-Giraldo, A Pandit, MJP Biggs (2016) The Effects of Electrodeposition Current Density on the Morphology, Electrochemical and Biological Characteristics of Poly (3, 4ethylenedioxythiophene): Poly (Styrenesulfonate RISH JOURNAL OF MEDICAL SCIENCE [Details]
	(2016)	*Front. Bioeng. Biotechnol* Catalina Vallejo-Giraldo, Eilís Dowd, Dulcé Papy-Garcia, Abhay Pandit, Manus J Biggs (2016) Functionalized PEDOT polymeric coatings for neuroelectrodes: topographical and biological strategies Front. Bioeng. Biotechnol [Details]
	(2016)	*10th World Biomaterials Congress* M Biggs, P Mokarian-Tabari, C Vallejo-Giraldo, D Thomas, M Morris, A Pandit (2016) Nanopillar modified neuroelectrodes through block copolymer self-assembly 10th World Biomaterials Congress [Details]
	(2016)	*BIODEVICES* Nathalia Peixoto, Tjerignimin Silue, Catalina Vallejo-Giraldo, Manus Biggs (2016) Electrochemical Analysis of Accelerated Aging of PEDOT-PTS Coated Screen-printed Electrodes BIODEVICES , pp.76-82 [Details]
	(2017)	*Orthopaedic Proceedings* CNM Ryan, MJ Biggs, A Pandit, DI Zeugolis (2017) MULTIFACTORIAL APPROACHES FOR TENOGENIC PHENOTYPE MAINTENANCE AND FUNCTION Orthopaedic Proceedings [Details]
	(2017)	*GLIA 2017* Alexandre Trotier, Laoise McNamara, Manus Biggs (2017) A novel model of mechanically induced inflammation in a primary culture using parallel flow shear stress GLIA 2017 [Details]
	(2017)	*GLIA 2017* A Kelly, GO Connor, M Biggs (2017) A functional analysis of nanotopographically modified platinum Iridium microelectrodes GLIA 2017 [Details]
	(2018)	*2018 EMF-Med 1st World Conference on Biomedical Applications of Electromagnetic Fields (EMF-Med)* Barry McDermott, Emily Porter, Martin O’Halloran, Anup Poudel, Manus Biggs, Nireeksha S Karode, Austin B Coffey (2018) 3D printable solid tissue-mimicking material for microwave phantoms 2018 EMF-Med 1st World Conference on Biomedical Applications of Electromagnetic Fields (EMF-Med) [Details]
	(2018)	*Orthopaedic Proceedings* M Fernandez, A Pandit, M Biggs (2018) USING MECHANICALLY LOADED PIEZOELECTRIC BIOMATERIALS TO DEFINE THE CELL MICROENVIRONMENT Orthopaedic Proceedings [Details]
	(2019)	*INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY* A Trotier, M Biggs (2019) Micromotion-induced neuroinflammation as a model of peri-electrode gliosis INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY [Details]
	(2019)	*NTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY* C Vallejo-Giraldo, IO Mohand, MB Huynh, K Krukiewicz, A Flannery, AR Pallipurath, A Trotier, M Kilcoyne, E Dowd, D Papy-Garcia, A Pandit, MJ Biggs (2019) Neuroelectrode functionalisation through heparan sulphate mimetics NTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY [Details]
	(2016)	*10th World Biomaterials Congress* Vallejo-Giraldo, C., Dowd, E., Papy-Garcia, D., Pandit, A. and Biggs, M.J. (2016) Functionalized PEDOT Polymeric Coatings for Neuroelectrodes: Topographical and Biological Strategies 10th World Biomaterials Congress [Details]
	(2016)	*Bioengineering in Ireland 2016, the Annual Conference of the Section of Bioengineering of the Royal Academy of Medicine in Ireland* Ryan, C.N.M., Biggs, M.J., Pandit, A. and Zeugolis, D.I. (2016) Multifactorial Approaches for Cell Phenotype Maintenance and Function Bioengineering in Ireland 2016, the Annual Conference of the Section of Bioengineering of the Royal Academy of Medicine in Ireland [Details]
	(2016)	*Bioengineering in Ireland 2016, the Annual Conference of the Section of Bioengineering of the Royal Academy of Medicine in Ireland* Vallejo-Giraldo, C., Dowd, E., Papy-Garcia, D., Pandit, A. and Biggs, M.J.P. (2016) PEDOT Polymeric Coatings for Neuroelectrodes: Topographical and Biologic Bioengineering in Ireland 2016, the Annual Conference of the Section of Bioengineering of the Royal Academy of Medicine in Ireland [Details]
	(2016)	*10th World Biomaterials Congress* Fernandez-Yague, M.A., Zeugolis, D., Pandit, A. and Biggs, M.J. (2016) Piezoelectric Nanoscaffolds: Mediating Tendon Regeneration through Activation of Piezoresponsive Receptors 10th World Biomaterials Congress [Details]
	(2016)	*Bioengineering in Ireland 2016, the Annual Conference of the Section of Bioengineering of the Royal Academy of Medicine in Ireland* Rahman, A.A., Tofail, S.A.M., Lukasz, B., Rodriguez, B.J., Biggs, M.J. and Pandit, A. (2016) Modification of Living Diatom, Thalassiosira weissflogii by Calcium Precursor as a Sacrificial Template for Development of Artificial Antigen Presenting Cell Bioengineering in Ireland 2016, the Annual Conference of the Section of Bioengineering of the Royal Academy of Medicine in Ireland [Details]
	(2016)	*10th World Biomaterials Congress* Biggs, M., Mokarian-Tabari, P., Vallejo-Giraldo, C., Thomas, D., Morris, M.A. and Pandit, A. (2016) Nanopillar Modified Neuroelectrodes through Block Copolymer Self-Assembly 10th World Biomaterials Congress [Details]
	(2016)	*10th World Biomaterials Congress* Pugliese, E., Larranaga, A., Fernandez-Yague, M., Vallejo Giraldo, C., Tadajon, G., Pandit, A. and Biggs, M.J. (2016) Investigating a Novel Polyhydroxyalkanoate/Multiwall Carbon Nanotubes Nanocomposite as an Electrically Conducting Implant Coating for Neuroprosthetic Devices 10th World Biomaterials Congress [Details]
	(2016)	*Bioengineering in Ireland 2016, the Annual Conference of the Section of Bioengineering of the Royal Academy of Medicine in Ireland* Fernandez-Yague, M.A., Zeugolis, D., Pandit, A. and Biggs, M.J.P. (2016) Piezoelectric Nanoscaffolds: Mediating Tendon Regeneration through Activation of Piezoresponsive Receptors Bioengineering in Ireland 2016, the Annual Conference of the Section of Bioengineering of the Royal Academy of Medicine in Ireland [Details]
	(2016)	*10th World Biomaterials Congress* Delgado, L., Fuller, K., Fernandez-Yague, M.A., Biggs, M., Pandit, A. and Zeugolis, D.I. (2016) Collagen Cross-Linking Increases Scaffold Stability while Modulates Pro-Inflammatory Macrophage Response 10th World Biomaterials Congress [Details]
	(2016)	*Tissue Engineering and Regenerative Medicine International Society (TERMIS) – EU Meeting* Ryan, C., Biggs, M.J., Pandit, A. and Zeugolis, D.I. (2016) Multifactorial Approaches for Cell Phenotype Maintenance and Function Tissue Engineering and Regenerative Medicine International Society (TERMIS) – EU Meeting [Details]
	(2014)	*TISSUE ENGINEERING AND REGENERATIVE MEDICINE* MJP Biggs, C Vallejo-giraldo, A Pandit (2014) Morphological modification of conducting polymers TISSUE ENGINEERING AND REGENERATIVE MEDICINE [Details]
	(2012)	*AMERICAN SOCIETY FOR CELL BIOLOGY Meeting* LC Santos, M Biggs, S Wind, M Dustin, M Sheetz (2012) Rigidity Sensing in T cells by Actin-Dependent Phosphorylation of Src Family Kinase Substrate Cas-L AMERICAN SOCIETY FOR CELL BIOLOGY Meeting [Details]
	(2007)	*Comparative Biochemistry and Physiology, Part A* M Biggs, M Dalby, C Wilkinson, N Gadegaard, G Richards (2007) The influence of nanoscale structures on osteoblast adhesion Comparative Biochemistry and Physiology, Part A [Details]

Published Reports

	Year	Publication
	(2020)	Self-powered piezo-bioelectronic device mediates tendon repair through modulation of mechanosensitive ion channels. Marc A. Fernandez-Yague, Alex Trotier, Sunny Akogwu Abbah1, Aitor Larrañaga1,2, Arun Thirumaran1, Aimee Stapleton3, Syed A. M. Tofail3, Matteo Palma4 , Abhay Pandit1 , and Manus J Biggs1 (2020) Self-powered piezo-bioelectronic device mediates tendon repair through modulation of mechanosensitive ion channels. bioRxiv, USA. [DOI] [Details]
	(2016)	Data on in vitro and in vivo cell orientation on substrates with different topographies. Andrew English, Ayesha Azeem, Kyriakos Spanoudes, Eleanor Jones, Bhawana Tripathi, Nandita Basu, Karrina McNamara, Syed AM Tofail, Niall Rooney, Graham Riley, Graham Cross, Dietmar Hutmacher, Manus Biggs, Abhay Pandit, Dimitrios I Zeugolis (2016) Data on in vitro and in vivo cell orientation on substrates with different topographies. Elsevier, USA. [Details]

Conference Poster

	Year	Publication
	(2005)	Cholecyst Derived Extracellular Matrix, a Potential Scaffold. 19th European Conference on Biomaterials. Anilkumar, T., Biggs, M., and Pandit A (2005) Cholecyst Derived Extracellular Matrix, a Potential Scaffold. 19th European Conference on Biomaterials. Sorrento, Italy: Conference Poster [Details]

Editorial

	Year	Publication
	(2016)	2D imprinted substrates and 3D electrospun scaffolds revolutionize biomedicine. Biggs, M;Pandit, A;Zeugolis, DI (2016) 2D imprinted substrates and 3D electrospun scaffolds revolutionize biomedicine. LONDON: Editorial [DOI] [Details]
	(2017)	Biomimetic Bioactive Biomaterials: The Next Generation of Implantable Devices. Tsiapalis, D;De Pieri, A;Biggs, M;Pandit, A;Zeugolis, DI (2017) Biomimetic Bioactive Biomaterials: The Next Generation of Implantable Devices. WASHINGTON: Editorial [DOI] [Details]
	(2018)	Smart Nanoparticles for Biomedicine Foreword. Loffredo, A,Biggs, M,Ciofani, G (2018) Smart Nanoparticles for Biomedicine Foreword. Editorial [Details]
	(2017)	Biomimetic Bioactive Biomaterials: The Next Generation of Implantable Devices. Tsiapalis, D,De Pieri, A,Biggs, M,Pandit, A,Zeugolis, DI (2017) Biomimetic Bioactive Biomaterials: The Next Generation of Implantable Devices. Editorial [DOI] [Details]
	(2018)	Foreword to special issue on two-dimensional biomaterials in regenerative medicine Editorial. Biggs, M,Zeugolis, D,Pandit, A (2018) Foreword to special issue on two-dimensional biomaterials in regenerative medicine Editorial. Editorial [DOI] [Details]

Reviews

	Year	Publication
	(2015)	An academic, clinical and industrial update on electrospun, additive manufactured and imprinted medical devices. Ryan, CNM;Fuller, KP;Larranaga, A;Biggs, M;Bayon, Y;Sarasua, JR;Pandit, A;Zeugolis, DI (2015) An academic, clinical and industrial update on electrospun, additive manufactured and imprinted medical devices. ABINGDON: Reviews [Details]
	(2015)	The past, present and future in scaffold-based tendon treatments. Lomas, AJ;Ryan, CNM;Sorushanova, A;Shologu, N;Sideri, AI;Tsioli, V;Fthenakis, GC;Tzora, A;Skoufos, I;Quinlan, LR;O'Laighin, G;Mullen, AM;Kelly, JL;Kearns, S;Biggs, M;Pandit, A;Zeugolis, DI (2015) The past, present and future in scaffold-based tendon treatments. AMSTERDAM: Reviews [DOI] [Details]
	(2016)	An insight into morphometric descriptors of cell shape that pertain to regenerative medicine. Lobo, J;See, EYS;Biggs, M;Pandit, A (2016) An insight into morphometric descriptors of cell shape that pertain to regenerative medicine. HOBOKEN: Reviews [DOI] [Details]