Wednesday, 2 October 2024

EU awards major research funding to tackle neurodegenerative disorders

University of Galway to lead multi-institutional study in Europe, supported by Joint Programme Neurodegenerative Disease Research   A research project aimed at advancing the understanding and treatment of neurodegenerative disorders has received €1.1 million in funding support by the European Union through the Joint Programme on Neurodegenerative Disease Research (JPND). The funding will spearhead a collaborative project, led by researchers at University of Galway, in partnership with institutions in Poland, Italy and Turkey. Neurodegenerative disorders, including Alzheimer's, Parkinson's, and Huntington's diseases, present a significant challenge due to their debilitating nature. Marked by the gradual deterioration of nerve cells, these conditions severely impact a person’s quality of life and place a substantial burden on patients, families, and healthcare systems. The research will be led by Dr Kasia Whysall with Dr Leo Quinlan, Principal Investigators and Associate Professors at the College of Medicine, Nursing and Health Sciences at University of Galway. Dr Whysall said: “This research endeavours to seek to unravel the complex mechanisms underlying neurodegeneration, with a particular focus on Alzheimer’s Disease. “Specific proteins which accumulate as a result of the disease have been studied, however their regulation poses challenges. "This project aims to uncover valuable insights into the early pathological processes driving neurodegeneration. "Our research suggests that early changes in the function of enzymes known as V-ATPase, and how this affects lysosomes – a type of recycling centre in the body that helps cells function properly, could be a key target for intervention to restore metabolic balance. We also found that damage to these cell parts might make neurons more vulnerable, supporting our investigation into treatment strategies that target gene regulation." The research will be driven by the pressing need for early detection and effective interventions, and will employ cutting-edge technologies and collaborative partnerships to explore novel pathways for development of treatments for Alzheimer’s disease. Central to the research will be the exploration of emerging biomarkers, including micro RNAs (miRs) and extracellular vesicles associated with these disorders and which hold promise as non-invasive indicators of disease onset and progression.             Dr Quinlan said: “Our goal is not only to identify potential biomarkers for early diagnosis, but also to elucidate the underlying mechanisms of neurodegenerative diseases. By combining our research with innovative therapeutic strategies, we hope to make significant strides towards improving the lives of individuals affected by these devastating conditions.”             Professor Martin O’Donnell, Executive Dean for the College of Medicine, Nursing and Health Sciences at University of Galway, said: “In addition to its potential implications for future clinical practice, this project is an opportunity to transform the landscape of neurodegenerative research, offering new avenues for targeting interventions and personalised treatments. The research partnerships established as part of this research underscores the importance of global cooperation in addressing pressing health challenges.” Ends


News Archive

Monday, 23 September 2024

Tá Ollscoil na Gaillimhe réidh chun fáilte a chur roimh na mílte mac léinn féideartha, tuismitheoirí, comhairleoirí gairmthreorach agus múinteoirí chuig Laethanta Oscailte na bliana seo – na cinn is mó riamh. Reáchtáltar an imeacht seo thar dhá lá i gcúig spás taispeántais suite ar fud an champais seo i lár na cathrach agus cois abhann, agus áirítear ann na céadta cainteanna ar chúrsaí agus ar ábhair chomh maith le deiseanna do dhaltaí blaiseadh ceart a fháil de shaol na hOllscoile seo. Beidh laethanta oscailte an fhómhair ar siúl Dé hAoine agus Dé Sathairn, an 4 agus an 5 Deireadh Fómhair, ó 9:00am go 3:00pm gach lá. Bhí an méid seo le rá ag Sarah Geraghty, Stiúrthóir Earcaíochta Mac Léinn agus For-rochtana in Ollscoil na Gaillimhe: “Is é cuspóir na Laethanta Oscailte seo blaiseadh ceart a thabhairt do mhic léinn ar shaol na hollscoile, agus é a chur ar a súile dóibh an t-iliomad deiseanna iontacha atá amach rompu. Is údar bróid dúinn a bheith rangaithe i measc an 2% is fearr d’ollscoileanna an domhain, agus i measc an 100 is fearr san Eoraip! Níos fearr ná sin, táimid rangaithe sa 34ú háit ar domhan, agus sa chéad áit in Éirinn, de réir Ranguithe Tionchair THE de thoradh ár gcuid oibre ar Spriocanna Forbartha Inbhuanaithe na Náisiún Aontaithe. “Tá ár léachtóirí, comhaltaí foirne agus mic léinn reatha iontacha ar bís le bualadh leo siúd a bheidh ina mic léinn amach anseo, agus cuidiú leo eolas a fháil ar na roghanna spreagúla staidéir agus gairme go léir atá ar fáil dóibh. Cuirimid os cionn 60 fochéim ar fáil a aithnítear go hidirnáisiúnta, lena n-áirítear Leigheas, Altranas, Eolaíochtaí Sláinte, na Dána, Eolaíocht, Innealtóireacht, Gnó, Dlí agus Bainistíocht Óstáin. Ina theannta sin, soláthraíonn breis agus 90% de na cúrsaí deiseanna chun tabhairt faoi shocrúchán oibre agus/nó staidéar thar lear chun a chinntiú go mbíonn céimithe réidh don ionad oibre, agus go mbíonn tóir ag fostóirí sa bhaile agus thar lear orthu. Níl an ollscoil seo le sárú ó thaobh na ndeiseanna foghlama atá ar fáil ón sárthaighde agus teagasc a bhíonn ar siúl ag na comhaltaí foirne acadúla anseo, rud a réiteoidh daoine óga do ghairm thairbheach áit ar bith ar domhan.” Buaicphointe Laethanta Oscailte na bliana seo is ea go dtabharfar rochtain eisiach ar roinnt de na háiseanna teagaisc agus foghlama is nuálaí dá bhfuil againn. Ina measc: Is féidir le daltaí atá ag cuimhneamh tabhairt faoin altranas amach anseo turas a fháil ar na háiseanna Altranais agus Cnáimhseachais. Cuirfear tús leis na turais in Áras Mhaighe Seola, an Zón Glas, ag 1pm agus 1:30pm an dá lá. Dóibh siúd ar spéis leo cúrsaí Dlí, ná cailltear an deis cuairt a thabhairt ar Chúirt Bhréige Scoil an Dlí ina n-athchruthaítear éispéireas an tseomra cúirte! Tá cúig thuras in aghaidh an lae, ach ní mór clárú roimh ré ag Seastán 45 sa Zón Oráiste. Tabharfaidh Coláiste na hEolaíochta agus na hInnealtóireachta turais ar Áras iontach na hInnealtóireachta, a thosófar i bhforhalla an Zóin Ghlais. Ba cheart do mhic léinn a bhfuil spéis acu san Fhisic clárú ag Seastán 6 sa Zón Corcra le haghaidh turas spreagúil ar na saotharlanna Fisice. Is féidir le lucht spéise na Drámaíochta páirt a ghlacadh i Máistir-rang Drámaíochta ag 1pm, nó i dturas ar Ionad Uí Dhonnchadha don Drámaíocht, an Amharclannaíocht agus an Taibhléiriú i bhforhalla an Zóin Ghoirm ag 11:30am. Beidh deis ag daoine a bhfuil dúil acu i gcúrsaí spóirt bualadh le cóitseálaithe agus lúthchleasaithe chun tuilleadh eolais a fháil ar na scoláireachtaí spóirt agus na háiseanna den scoth atá ar fáil anseo. Beidh na sonraí go léir le fáil gach lá in The Cube, sa Zón Oráiste. Ina theannta sin, tabharfar deis do dhaltaí lóistín an champais a fheiceáil agus blaiseadh a fháil de shaol an mhic léinn. Cuirfear fáilte roimh thuismitheoirí chuig léacht speisialta do Thuismitheoirí ag 11:30am Dé Sathairn, ina bhfaighidh siad go leor leideanna faoin gcaoi is fearr chun tacú le mic léinn agus iad ag aistriú go dtí an ollscoil. Is gá clárú roimh ré, agus tá tuilleadh eolais agus an clár iomlán ar fáil ag www.universityofgalway.ie/opendays, nó trí ríomhphost a sheoladh chuig opendays@universityofgalway.ie. Críoch

Monday, 23 September 2024

University of Galway is set to welcome thousands of prospective students, parents, guidance counsellors and teachers to this year’s Open Days - the largest ever. The event runs over two days with five exhibition spaces spread across the city-centre, riverside campus, with more than 100 course and subject talks and opportunities for students to get a real feel for what life at the University is all about. The Open Days take place on Friday, October 4th, and Saturday, October 5th, from 9:00am to 3:00pm each day. Sarah Geraghty, Director of Student Recruitment and Outreach at University of Galway, said: “Our Open Days are all about giving students a real feel for college life and showing just how many incredible opportunities lie ahead. We're proud to be ranked in the top 2% of universities worldwide and in the top 100 in Europe! Even better, we're ranked 34th globally and number 1 in Ireland by the THE Impact Rankings for our work on the UN’s Sustainable Development Goals. “Our amazing lecturers, staff, and current students can’t wait to meet future students and help them discover all the exciting study and career paths waiting for them. We offer more than 60 internationally recognised undergraduate degrees including Medicine, Nursing, Health Sciences, Arts, Science, Engineering, Business, Law and Hotel Management. And alongside that, more than 90% of the courses offer a work placement and/or study abroad opportunity, ensuring graduates are workplace ready, and much sought after by employers at home and abroad. The opportunities to learn from the excellent research and outstanding teaching of our academic staff is second to none and will set any young person up for a rewarding career, anywhere in the world.” A highlight of this year’s Open Days will be exclusive access to some of our most innovative teaching and learning facilities including: Future nursing students can tour the Nursing and Midwifery facilities, with tours departing from Áras Moyola, Green Zone at 1pm and 1:30pm on both days. Law enthusiasts should not miss a chance to visit the School of Law’s Moot Court, which replicates a real courtroom experience! There are five tours daily, and advance registration is required at Stand 45 in the Orange Zone. The College of Science and Engineering will host tours of their impressive Engineering Building, with tours starting from the Green Zone foyer. Students interested in Physics should register at Stand 6 in the Purple Zone for an exciting tour of our Physics labs. Drama lovers can participate in a Drama Master Class at 1pm, or take a tour of the O’Donoghue Drama and Theatre Performance Centre at the Blue Zone Foyer at 11:30am. Sports enthusiast will have the opportunity to meet with coaches and athletes to learn more about our sports scholarships and state-of-the-art facilities. Full details will be available in The Cube in the Orange Zone daily. Students will also have the chance to explore the campus accommodation and get a taste of student life, and parents are invited to attend a special Parents’ Talk at 11:30am on Saturday, packed with helpful tips on how to best support students as they transition to university. Advance registration is required, with further information and the full programme available at www.universityofgalway.ie/opendays, or by emailing opendays@universityofgalway.ie. Ends

Thursday, 19 September 2024

Clinical data showing the prevention of hair loss and peripheral neuropathy in chemotherapy patients sees ARTIS Ventures lead investment syndicate which includes heavyweight Silicon Valley backers such as 8VC and Lachy Groom. Luminate, a University of Galway spin-out company that aims to help deliver cancer treatment at home, has raised $15 million in a Series A investment. The funding comes after first-in-patient clinical trials of the company’s devices to prevent hair loss and peripheral neuropathy in chemotherapy patients showed successful results. 30 jobs are being created at the company’s Galway base as it prepares to launch in the US next year. The round was led by ARTIS Ventures, with participation from Metaplanet, Lachy Groom, 8VC, and healthcare executives from companies such as Dexcom, alongside existing investors SciFounders, Faber and others. Research suggests that over 10% of cancer patients’ lives are spent in hospital. Luminate is developing a series of products to enable home administration of anti-cancer treatments, allowing patients to spend less time in clinic. For physicians, Luminate’s technology helps to meet the growing demand for cancer infusion clinic space caused by rising numbers of cancer cases. To enable at-home cancer treatment, Luminate is developing a series of technologies to prevent treatment side effects that require in-person monitoring, facilitate patient-led delivery of therapeutics, and monitor key adverse events during treatment. The company’s first two products focus on preventing the side effects of cancer treatment which require in-clinic monitoring. Lilac, a wearable set of gloves and boots, is designed to prevent peripheral nerve damage in the hands and feet of cancer patients – a debilitating condition that requires frequent in-person monitoring of patients. Meanwhile, Lily, a wearable cap-like device designed to be worn during chemotherapy, allows patients to prevent hair loss caused by chemotherapy. In addition to these initial products, the team has begun the development of a novel system, Lotus, designed to enable at-home administration of low-risk anti-cancer drugs by patients. Luminate, which participated in the Y Combinator S21 Batch, plans to use the funds to continue development of its Lotus technology through to first-in-patient trials, and to complete large-scale clinical trials of its Lily and Lilac products in the US, before proceeding to FDA review and market launch. First revenues from its side effect prevention platform are expected in 2025.             Aaron Hannon, CEO and Co-Founder of Luminate, said: “Our mission at Luminate is to deliver every cancer treatment in the patient’s home. In order to make home delivery possible, we need to build tools to prevent side effects that require in-person monitoring, monitor urgent adverse events during treatment, and enable patients to complete infusion procedures alone. This funding allows us to take the first step of this vision: showing we can prevent important adverse events like neuropathy in large scale trials and on the market. Alongside achieving these key milestones, we continue to expand our world class team in the US and Ireland, with a number of open roles in product development, operations, and clinical. We’re excited to partner with a strong investor base to make our vision of at-home cancer care a reality.”             Commenting on the fundraise, Austin Walne, Partner at ARTIS Ventures said: "Luminate has an opportunity to significantly reduce the painful side effects cancer patients endure when undergoing chemotherapy treatments. The Luminate team have the potential to unlock value for private practice oncologists across the United States, reduce costs to insurers through at-home care delivery, and create a better experience for patients while they fight to win their battles with cancer.” Luminate was founded in 2018 by Aaron Hannon, Dr Barbara Oliveira and Professor Martin O’Halloran when the group were working as medical device researchers at the University of Galway, Ireland. Headquartered at the University’s Business Innovation Centre, the team has since grown to over 33 people employed in the US, Ireland, and Georgia. The current funding round brings the University of Galway spin out’s total funding to over $25 million to date, including grant funding from Europe’s EIC Accelerator and Enterprise Ireland’s Disruptive Technology Innovation Fund. The company is currently recruiting for roles in software development, electronics, mechanical design, R&D, and manufacturing to join the team at its Galway office, and clinical researchers to join its remote US workforce as it launches US multi-centre studies. Ends


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