A new study by researchers at the University of Galway and the University of Limerick suggests that electrical stimulation might be essential for tendons to maintain their health, offering fresh possibilities in tendon repair and regeneration.   The research took place at the CÚRAM Research Centre for Medical Devices, funded through Taighde Éireann – Research Ireland, formerly Science Foundation Ireland.  Tendons resist intense mechanical stress, while facilitating force transmission from muscles to bones. They are also piezoelectric, meaning that when they are stretched, they will produce an electric field, which is thought to be important for regulating tendon cell function. However, when injured, tendons offer limited healing, which often leads to chronic pain and disability, thus affecting patient productivity.   In 2023, major tears or traumatic injuries to tendon, ligaments and muscles affected nearly half a million people in full-time employment in the United States.   Recovery from tendon injuries is slow and often requires extensive rehabilitation, which causes nearly two months of lost work-days per injury. Current regenerative medicine for tendon repair has so far failed to recreate tendon cells' native environment, which ultimately hampers their therapeutic potential.   Led by Dr Marc Fernandez-Yague, who completed his PhD while a researcher with CÚRAM at University of Galway, the research team focused on understanding how electrical and mechanical signals work together to control tendon cell function. Traditionally, tendon cells are extremely difficult to culture in the lab as they rapidly and irreversibly lose their tendon-like functions once isolated from the body.   To address these challenges, the team developed a novel cell culture device - a "tympanic piezoelectric bioreactor" that works in a similar way to the human eardrum and which delivered mechanical vibrations and electrical stimuli to tendon cells.   This dual stimulation caused cells to better retain their healthy, tendon-specific properties, while being expanded in the lab, allowing them to be utilized in tissue repair and regeneration approaches.  Dr Fernandez-Yague said: “Our work is rooted in a deep understanding of how cells sense and interact with their environment. Until now, tendon cells are grown in the lab in a specialised device which stretches them to mimic the effects of body movement. However, this approach overlooks that tendon tissues are piezoelectric – they generate electrical signals when subjected to mechanical stress. Our research project engineered a dynamic electrical-mechanical stimulation systems, which provides cells with the specific signals they need to successfully guide their development, thereby recreating key environmental conditions observed during normal tissue formation and repair.”  Dr Manus Biggs, Associate Professor at University of Galway and principal investigator of the study, outlined some wider implications of the research: “While our approach shows great potential for ultimately growing tendon tissues in the lab, it also has significant implications for generating other tissues that respond to dual electrical and mechanical forces, such as cartilage, bone, and even cardiovascular tissues. This study opens up new possibilities for developing therapies that promote tissue reinforcement and offer alternative or complementary strategies to current physical rehabilitation methods.  “We understand that traditional musculoskeletal therapies often rely on physical therapy which provides mechanical signals to the cells of regenerating tissues. In contrast, incorporating electrical stimulation provides greater precision in controlling how cells respond, offering a more effective approaches for applications in regenerative medicine. Critically, tendon piezoelectricity has long been alluded to have physiological functions. This study is one of the first of its kind that shows that piezoelectric signals can regulate cell differentiation and development.”  The full paper is available at: https://onlinelibrary.wiley.com/doi/10.1002/advs.202405711   Ends 

Dámhachtainí Oinigh le bronnadh ar dheichniúr daoine clúiteacha Beidh breis agus 3,300 mac léinn ag filleadh ar an gcampas chun go mbronnfar a gcáilíocht acadúil orthu ag searmanais bhronnta an gheimhridh in Ollscoil na Gaillimhe. Cuirfear tús leis an gceiliúradh ar an gcampas inniu agus leanfar leis go dtí Dé Céadaoin, an 27 Samhain. I rith na seachtaine freisin bronnfaidh an Ollscoil céimeanna oinigh ar an deichniúr seo a leanas mar aitheantas as a bhfuil bainte amach acu agus as an obair atá déanta acu: Martin Griffiths, Fo-Ard-Rúnaí na Náisiún Aontaithe le haghaidh Gnóthaí Daonnúla agus Comhordaitheoir na Fóirithinte Éigeandála – Dochtúir le Dlíthe Tony Connelly, iriseoir agus údar, agus Eagarthóir Eorpach Nuacht RTÉ – Dochtúir le Litríocht Keith Finnegan, craoltóir agus iarláithreoir an chláir Galway Talks ar Galway Bay FM – Dochtúir le Litríocht Dolores Keane, amhránaí tíre Éireannach den stíl thraidisiúnta a bhfuil cáil idirnáisiúnta uirthi – Dochtúir le Ceol An tOllamh Paul Yock agus an Dr Joshua Makower, bunaitheoirí Stanford Biodesign a thug tacaíocht do bhunú BioInnovate Ireland – Dochtúir le hEolaíocht Owen Reidy, Ard-Rúnaí Chomhdháil na gCeardchumann (ICTU) – Dochtúir le Dlíthe An Dr Éanna Ní Lamhna, luibheolaí agus feithideolaí, láithreoir agus craoltóir – Dochtúir le hEolaíocht Marina Fiddler agus Tara Nic Dhiarmada, bunaitheoirí MADRA – Mutts Anonymous Dog Rescue and Adoption – Dochtúir le Dlíthe                        Dúirt Uachtarán Eatramhach Ollscoil na Gaillimhe, an tOllamh Peter McHugh: “Tá lúcháir orm a bheith in ann aitheantas a thabhairt don ghrúpa daoine eisceachtúla seo, agus an gradam seo a bhronnadh orthu agus muid ag déanamh ceiliúradh chomh maith ar a bhfuil bainte amach ag 3,350 mac léinn dár gcuid i gceithre Choláiste na hOllscoile. Tréaslaím leis na daoine clúiteacha seo ar fad, agus beimid ag teacht le chéile mar phobal ollscoile le hómós a léiriú dóibh sin, agus do na daoine a bhfuil a gcéim le bronnadh orthu, ag searmanais bhronnta an gheimhridh. Is ócáidí iad seo a bhfuil tábhacht leo. Meabhraíonn siad dúinn go léir an chúis a bhfuilimid ann agus an méid a dhéanaimid ar son mhic léinn na hOllscoile seo.”                Bhí an méid seo le rá ag an Ollamh Becky Whay, an tUachtarán Ionaid agus Meabhránaí Eatramhach: “Ba mhaith liom comhghairdeas a dhéanamh le gach céimí as a gcéim a bhaint amach. Is léiriú é ar a gcumas, a saothar agus a ndúthracht le blianta fada. Ba mhaith liom freisin comhghairdeas a dhéanamh leis na daoine eisceachtúla a mbronnfar céimeanna oinigh orthu. Tá a chion féin déanta ag gach céimí oinigh díobh sna réimsí éagsúla seo a leanas: forbairt pobail, an saol poiblí, cultúr agus taibhiú, cearta an duine, agus taighde. Thar ceann Ollscoil na Gaillimhe tá áthas orm ómós a léiriú dóibh as a bhfuil bainte amach acu.”   Tá sceideal iomlán shearmanais bhronnta an gheimhridh 2024 le fáil ag https://www.universityofgalway.ie/conferring/guide/autumn-conferring/   Críoch

Ten distinguished individuals receive Honorary awards More than 3,300 students are returning to campus to receive their academic awards at University of Galway’s winter conferring ceremonies. The celebrations begin today and continue until Wednesday November 27th on campus. Throughout the week the University will also award honorary degrees to 10 individuals in recognition of their achievements and work including: Martin Griffiths, United Nations Under-Secretary-General for Humanitarian Affairs and Emergency Relief Coordinator - Doctor of Laws Tony Connelly, journalist and author and Europe Editor for RTÉ News - Doctor of Literature Keith Finnegan, broadcaster and former presenter of Galway Talks on Galway Bay FM - Doctor of Literature Dolores Keane – internationally-renowned, traditional Irish folk singer - Doctor of Music Professor Paul Yock and Dr Joshua Makower, founders of Stanford Biodesign and supporters of establishment of BioInnovate Ireland - Doctor of Science Owen Reidy, General Secretary of the Irish Congress of Trade Unions (ICTU) - Doctor of Laws Dr Éanna Ní Lamhna, botanist and entomologist, presenter and broadcaster - Doctor of Science Marina Fiddler and Tara Nic Dhiarmada, founders of MADRA – Mutts Anonymous Dog Rescue and Adoption - Doctor of Laws                        Professor Peter McHugh, Interim President of University of Galway, said: “I am delighted to be in a position to recognise this group of extraordinary individuals, and to recognise them at the same time as we celebrate the achievements of 3,350 of our students across our four Colleges. I congratulate each of these distinguished individuals and look forward to coming together as a university community to honour them, with our graduands, at our winter ceremonies. These are important occasions for us all, reminding us why we are here and what we do for our students.”                Professor Becky Whay, Interim Deputy President and Registrar, said: “I would like to congratulate each graduate on their achievement in earning their degrees, marking the culmination of their talent, effort and commitment over many years. I would also like to extend my congratulations to the exceptional individuals being bestowed with honorary degrees. Each one has made an outstanding and distinctive contribution in the diverse fields of community development, public life, culture and performance, human rights, and research. On behalf of University of Galway I am delighted to honour them and their achievements in this way.”   The full schedule for the 2024 winter conferring ceremonies is available at https://www.universityofgalway.ie/conferring/guide/autumn-conferring/   Ends