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About University of Galway
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Accessibility & LanguageMass Spectrometry
Overview
Targeted mass spectrometry is a gold standard technique for precise compound quantification and is widely used in industry and clinical laboratories. This powerful technology enables efficient translation from research discoveries to commercial applications. The Mass spectrometry Core Facility supports diverse projects across biology, chemistry and environmental science. The MS Core Facility supports the analysis of diverse sample types, ranging from biological fluids, tissues, and cells to environmental and small-molecule chemistry samples.
The core is expanding into MS-driven proteomics, metabolomics, and lipidomics using advanced mass spectrometry workflows. These approaches analyze proteins, small-molecule metabolites, and lipids, respectively, providing systems-level insight into complex biology and disease.
Targeted Mass Spectrometry
Multiple Reaction Monitoring (MRM) is a targeted mass spectrometry (MS) technique for quantifying small molecules—including lipids, metabolites and chemical compounds. MRM is carried out using triple quadrupole (QqQ) mass spectrometers, a gold standard platform for targeted quantification. In a typical MRM experiment, analytes are first separated by HPLC, then ionized and introduced into a triple quadrupole mass spectrometer, where the first quadrupole (Q1) isolates precursor ions, the second quadrupole (Q2) induces collision‐activated dissociation, and the third quadrupole (Q3) selectively transmits target fragment ions for quantitative detection.
Mass Spectrometry Core Facility Equipment
SCIEX 4500 QTRAP
A highly sensitive and reliable hybrid triple quadrupole-linear ion trap (LC-MS/MS) for high-throughput qualitative and quantitative analysis.
Source: Electrospray ionization (positive and negative mode).
Mass range: 5-2000 m/z
Mass Analysers: Hybrid: Quadrupole-linear ion trap
Fragmentation: Collision induced fragmentation (CID)
Agilent 6460
A robust and versatile triple quadrupole mass spectrometer capable of supporting multiplexed analysis of analytes with high selectivity and low background noise.
Source: Electrospray ionization (positive and negative mode).
Mass range: 5-3000 m/z
Mass Analysers: triple quadrupole
Fragmentation: Collision induced fragmentation (CID)
For more information, please contact massspec@universityofgalway.ie.
