Researchers at University of Galway have developed a way of bioprinting tissues that change shape as a result of cell-generated forces, in the same way that it happens in biological tissues during organ development. The breakthrough science focused on replicating heart tissues, bringing research closer to generating functional, bioprinted organs, which would have broad applications in disease modelling, drug screening and regenerative medicine. The research was led by a team at the School of Engineering and CÚRAM Research Ireland Centre for Medical Devices at University of Galway and has been published in the journal Advanced Functional Materials. Bioprinting technology uses living cells within specialised “bioink” materials – a substance or material which can support living cells, and due to its characteristics, it can aid cell adhesion, proliferation and differentiation during maturation. The technology offers immense promise for creating lab-grown organs that closely resemble the structure of their human equivalent. However, bioprinting fully functional organs remains a significant hurdle. For instance, while bioprinted heart tissues can contract, their force of contraction is often considerably weaker than that of a healthy adult heart. Traditional bioprinting methods often aim to directly recreate the final anatomical shape of an organ, like the heart – therefore overlooking the crucial role of dynamic shape changes during natural embryonic development. For example, the heart begins as a simple tube that undergoes a series of bends and twists to form its mature four-chambered structure. These shape-morphing behaviours are essential for sculpting heart cell development and maturation. The University of Galway research team recognised this and developed a novel bioprinting technique that incorporates crucial shape-changing behaviours. Ankita Pramanick, lead author of the study and CÚRAM PhD Candidate at University of Galway, said: “Our work introduces a novel platform, using embedded bioprinting to bioprint tissues that undergo programmable and predictable 4D shape-morphing driven by cell-generated forces. Using this new process, we found that shape-morphing improved the structural and functional maturity of bioprinted heart tissues.” The research showed that cell-generated forces could guide the shape-morphing of bioprinted tissues, and it was possible to control the magnitude of the shape changes by modifying factors such as the initial print geometry and bioink stiffness. Morphing was found to sculpt cell alignment and enhance the contractile properties of the tissues. The research team also developed a computational model that could predict tissue shape-morphing behaviour. Professor Andrew Daly, Associate Professor in Biomedical Engineering and CÚRAM funded investigator and principal investigator on the project, said: “Our research shows that by allowing bioprinted heart tissues to undergo shape-morphing, they start to beat stronger and faster. The limited maturity of bioprinted tissues has been a major challenge in the field, so this was an exciting result for us. This allows us to create more advanced bioprinted heart tissue, with the ability to mature in a laboratory setting, better replicating adult human heart structure. We are excited to build on this shape-morphing approach in our ongoing European Research Council project, which is focused on developmentally-inspired bioprinting. “We are still a long way away from bioprinting functional tissue that could be implanted in humans, and future work will need to explore how we can scale our bioprinting approach to human-scale hearts. “We will need to integrate blood vessels to keep such large constructs alive in the lab, but ultimately, this breakthrough brings us closer to generating functional bioprinted organs, which would have broad applications in cardiovascular medicine.” The full study can be read in Advanced Functional Materials here: https://onlinelibrary.wiley.com/doi/10.1002/adfm.202414559#adfm202414559-bib-0004  Ends  

University of Galway’s Farmer’s Yards finds a new home in rural life of Pennsylvania Farmer’s Yards, a social initiative developed at University of Galway for the farming community, has been launched in the United States. Pennsylvania Farm Link, a non-profit dedicated to forging connections that secure the future of farming in the state, has adopted the novel programme as part of its efforts to respond positively to mental health and wellbeing issues facing farmers, while creating opportunities to enhance social inclusion within the farming community, especially for older farmers. Farmer’s Yards was initiated and developed by Dr Shane Conway at University of Galway’s Rural Studies Centre, with support from the University’s Illuminate Programme. The establishment of the initiative in Pennsylvania has been funded by the Northeast Extension Risk Management Education Center located at the University of Delaware through the United States Department of Agriculture (USDA) National Institute of Food and Agriculture. The first Farmer’s Yards gathering in the US took place at the 109th Pennsylvania Farm Show that took place from the 4th to 11th of January 2025 in Harrisburg, bringing together 32 farmers from across the state to network with each other and reflect on the challenges of farm life. Dr Conway said: “The recent implementation of Farmer’s Yards in Pennsylvania showcases its universal appeal and adaptability for farming communities across the world. Farmers aged 65 and older are now the fastest-growing demographic of the farming population globally and this initiative provides a vital social outlet for older farmers to stay actively involved in their local community in later life. This is important because for many, farming is more than a job - it’s their identity and way of life. “Farmer’s Yards offers a meaningful way for these farmers to stay connected and engaged with fellow farmers at a similar stage of life, fostering inclusion and addressing the uncertainties and fears that often accompany stepping back from active farming. Whether adapting to age-related physical limitations or navigating the transition of the farm to the next generation, this initiative ensures that older farmers continue to be respected and valued members of the farming community as they age, contributing positively to their mental health and overall wellbeing.” Darlene Livingston, Executive Director, Pennsylvania Farm Link said: “Farmer’s Yards in Pennsylvania is designed for our farming community’s particular interests, requirements and values, in accordance with then model developed at University of Galway. The important role that the initiative plays in ensuring active social participation and inclusion for farmers as they age was evident with so many farmers in their 70s and 80s taking part. Such engagement will help prevent them from being isolated and feeling excluded from society in later life.”   The Farmer’s Yards provides farmers with a platform to maintain legitimate social connectedness, collegiality, and comradeship with their peers where they live, and in turn, combat social isolation and loneliness, something that is particularly beneficial for older farmers who have few other social outlets and may live alone. Pennsylvania Farm Link is planning further gatherings in rural communities across the state in the coming months as part of the adoption of the initiative. Farmers who take part are also exposed to a diverse set of farmer-focused knowledge transfer and exchange activities, such as succession planning, thereby helping them to successfully adapt through, and beyond, times of stress and distress. Ends  

Two University of Galway Law students, Mamadou Saliou Bah and Salma Smith were recently awarded RDJ Diversity and Inclusion Scholarships, worth €5,000 and a work placement opportunity with leading Irish law firm RDJ.  This year marks the first year of the RDJ Diversity and Inclusion Scholarship at University of Galway which support students from ethnic minorities and those who are under-represented in the legal profession in Ireland. RDJ has donated €100,000 over ten years for the scholarships, which are awarded to two University of Galway Law students each academic year. Mamadou and Salma were chosen as the scholarship recipients following a competitive selection and interview process based on exam results, a personal statement, a 1,000-word essay discussing the topic, “The Need for Diversifying the Legal Profession in Ireland”. The students were officially awarded their scholarships on campus by JP Gilmartin, Partner-in-Charge of RDJ's Galway office, Antoinette Vahey, Partner at RDJ, and Professor Martin Hogg, Dean of the University of Galway School of Law.             Commending the RDJ Diversity Scholars on their achievement, JP Gilmartin, Partner-in-Charge of RDJ's Galway office, said: “I am delighted to meet this year’s recipients of the RDJ Diversity Scholarship today. Mamadou and Salma are both outstanding students and I look forward to following what I have no doubt will be successful career paths for them both.”             Antoinette Vahey, Partner in RDJ’s Employment Group added: “Greater diversity and inclusion are among RDJ’s core values. This scholarship is in keeping with our commitment to creating a workplace that reflects the diversity of our clients and the communities we are part of.”             Acknowledging the importance of encouraging diversity in the legal profession, Professor Martin Hogg, Dean of University of Galway’s School of Law, said: “RDJ’s support in creating these two scholarships is sincerely appreciated by the School of Law. The two worthy inaugural recipients, Mamadou and Salma, will benefit greatly from them, receiving transformative support and encouragement to pursue legal careers in an increasingly diverse legal profession.” Ends