A new international study led by University of Galway suggests that having higher levels of vitamin D in middle age is associated with lower levels of tau protein in the brain, which is a sign of dementia, years later. The study does not prove that vitamin D levels lower the level of tau in the brain or the risk of dementia; it only shows an association.  The findings have been published today in Neurology Open Access, an official journal of the American Academy of Neurology. Study findings Higher vitamin D levels are associated with lower levels of the Alzheimer’s biomarker, tau protein in the brain, years later. Higher vitamin D levels may protect against dementia. The study does not prove cause and effect; it only shows an association. The results need to be confirmed with additional studies. The study was led by Professor Emer McGrath and Dr Martin Mulligan, from the College of Medicine, Nursing and Health Sciences at University of Galway and Galway University Hospital. It was carried out in collaboration with Boston University, the Framingham Heart Study and University of Texas San Antonia. Senior author, Professor Emer McGrath, Associate Professor in Medicine, University of Galway and Consultant Neurologist, Galway University Hospital, said: “This study demonstrates an association between higher vitamin D in mid-life and a lower burden of abnormal tau protein in the brain, a marker of Alzheimer’s disease. Vitamin D in mid-life could be an important factor to protect future brain health. While previous research has linked low vitamin D in adults over 70 with an increased risk of dementia, this study is among the first to look at younger adults at mid-life, around the average age of 39. Low vitamin D in mid-life may be an important target to reduce the risk of early signs of preclinical dementia in the brain. “However, while these findings are very interesting, they only demonstrate an association between vitamin D and early signs of dementia in the brain. Further studies, for example a clinical trial, will be required to determine if vitamin D supplements could prevent dementia." Lead author, Dr Martin Mulligan, PhD researcher at University of Galway, said: "We found that higher vitamin D levels were associated with lower tau deposition in regions of the brain that are known to be affected earliest in Alzheimer's disease. These results suggest that higher vitamin D levels in midlife may offer protection against developing these tau deposits in the brain and that low vitamin D levels could potentially be a risk factor that could be modified and treated to reduce the risk of dementia. However, these results need to be further tested with additional studies.” The study involved nearly 800 people with an average age of 39 who did not have dementia. All participants had the level of vitamin D in their blood measured at the start of the study. They had brain scans an average of 16 years later that measured levels of tau and amyloid beta proteins in the brain, which are both biomarkers for Alzheimer’s disease. A high level of vitamin D was defined as greater than 30 nanograms per milliliter (ng/mL) and a low level was less than that number. A total of 34% of participants had low levels of vitamin D and 5% were taking vitamin D supplements. The results took into account other factors that could affect tau levels, such as age, sex and symptoms of depression. The results showed that higher vitamin D levels are associated with lower levels of the Alzheimer’s biomarker tau protein years later. Dr Mulligan added: “These results are promising as they suggest an association between higher Vitamin D levels in early middle age and lower tau burden on average 16 years later. Mid-life is a time where risk factor modification can have a greater impact.” A limitation of the study is that the blood level of vitamin D was measured only once. Professor McGrath added: “The findings do support the need for clinical trials to determine if Vitamin D supplementation in younger adults could delay or help prevent the onset of dementia." The Framingham Heart Study is the longest running longitudinal cohort study worldwide. It started in 1948 with the recruitment of 5,200 adults from the town of Framingham in Massachusetts, Boston, with approximately 15% of the participants of Irish ancestry. The study was supported by the National Institute on Aging, National Institute of Neurological Disorders and Stroke, Irish Research Council and Health Research Board of Ireland. The full study can be read here. Ends

University of Galway’s Shannon College of Hotel Management has announced a new partnership with The Address Collective, a family-run hospitality group with seven hotels across Ireland and the UK.  At the centre of the partnership is The Address Collective Excellence Scholarship, which will support full-time undergraduate students who qualify for SUSI funding and are studying hospitality, business or related disciplines.  The scholarship reflects a shared commitment between Shannon College and The Address Collective to support students pursuing careers in hospitality by providing financial assistance and opportunities to connect with the industry.  The Address Collective employs a number of Shannon graduates across its hotels, including The Address Connolly, The Address Cork, The Address Glasgow, The Address Sligo and The Address Citywest, as well as two upcoming properties, The Address Capel and The Address Wren. The partnership aims to build on this relationship and support student career opportunities in the hospitality sector.  The Address Collective provides training, mentoring and development opportunities for staff, with many employees progressing from entry-level roles to supervisory and management positions. The group is also actively engaged in community partnerships and charitable initiatives across the areas where it operates.  Cathal McGettigan, Director at The Address Collective, said: “At The Address Collective, we are passionate about supporting the future of the hospitality industry. Shannon College has a long-standing reputation for producing exceptional graduates who bring professionalism, creativity and leadership into the sector. We are proud to partner with the college to launch The Address Collective Excellence Scholarship, helping talented students access the education and opportunities they need to build successful careers in hospitality. As Shannon Alumni ourselves, Michaela and I are delighted to be here today. Many Shannon graduates are already valued members of our team across our hotels, and we look forward to welcoming many more in the years ahead.”   Adrian Sylver, Head of Shannon College of Hotel Management, said: “We are delighted to launch this annual scholarship in partnership with The Address Collective, and it is particularly special to mark this with Cathal McGettigan and Michaela Hegarty, both graduates of Shannon College of Hotel Management. At Shannon we take great pride in seeing our alumni go on to make such a strong impact in the hospitality industry and to support future students through this generous initiative. This partnership speaks to the enduring strength of the Shannon community and the importance of giving back.”              Professor Alma McCarthy, Executive Dean of the College of Business, Public Policy and Law at University of Galway, said: “This partnership with The Address Collective strengthens the career pathways available to students at Shannon College of Hotel Management. Students will have the chance to gain experience with an Irish family run hotel group that operates across Ireland and the UK, supporting their transition from study into a sector that continues to grow and diversify.”    More information on The Address Collective Excellence Scholarship is available here.   Ends

A law professor and former president of University of Galway are among new appointees to the Council of State by President of Ireland Catherine Connolly.   Professor Donncha O’Connell of the School of Law is one of seven nominees alongside Ciarán Ó hÓgartaigh, who was president of the University between 2018 and 2024.    The Council of State is the constitutional body that advises the President on the exercise of certain powers such as the referral of Bills to the Supreme Court under Article 26 of the Constitution.    President of University of Galway, Professor David Burn, said: “My congratulations to all of the President Catherine Connolly’s nominees, in particular our Professor O’Connell and one of my predecessors in the role of President, Ciarán Ó hÓgartaigh. It is a great tribute to the esteem in which they are held as individuals and also to University of Galway. I wish them well in supporting and advising the President.”   Professor O’Connell joined the staff of University of Galway in 1993 and became an Established Professor in 2013. A native of Swinford, Co Mayo, he has served terms as Dean of the Faculty of Law and Head of the School of Law.    He also served two terms as a Commissioner of the Law Reform Commission and was a member of the Commission on the Future of Policing in Ireland and a board member of the Legal Aid Board. More recently, he was a member of the Independent Review Group to consider the Offences Against the State Acts.    He has served on the boards of a number of human rights organisations including, INTERIGHTS, FLAC and Amnesty International – Ireland, and was, while on leave of absence from the University, the first full-time Director of the Irish Council for Civil Liberties (ICCL). He was the Irish member of the EU Network of Independent Experts on Fundamental Rights and, later, the Senior Irish member of FRALEX, the legal expert group that advised the EU Fundamental Rights Agency based in Vienna.   He also served for over nine years on the board of the internationally-acclaimed Druid Theatre Company.    Ciarán Ó hÓgartaigh is a former Professor of Accounting and Dean of the business schools at UCD. A Galway native and an alumnus, he was appointed president of University of Galway in 2018 where he led a new strategic vision for a university with values, and a university for the public good. He was also Chairperson of Universities Ireland, encouraging co-operation between the universities on the island of Ireland. He has a PhD from the University of Leeds and was a Fulbright Scholar at Northeastern University in Boston.   Mr Ó hÓgartaigh is on the board of the National Library of Ireland, on the Council of the Economic and Social Research Institute and on the editorial board of Studies. Scríobhann sé alt as Gaeilge ó am go chéile don Irish Times.   Professor O’Connell is one of a number of University of Galway staff to have served on the Council of State while working at the University. They include: the late Professor Emer Colleran who was appointed by President Mary Robinson; Professor Ruth Curtis who was appointed by President Mary McAleese; and Professors Gearóid Ó Tuathaigh and Gerard Quinn who were appointed by President Michael D Higgins. The former chair of Údarás na hOllscoile, Judge Catherine McGuinness, also served on the Council of State of Presidents Patrick Hillery and Michael D Higgins.    Ends