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Medicine

Dr. Sharon Glynn

BSc, MPH, PhD.

Contact Details

Professor in Pathology
Lambe Institute for Translational Research
School of Medicine
NUI Galway
T: +353-91-494242
E: sharon.glynn@nuigalway.ie
 
researcher
 

Biography

Dr. Sharon Glynn is a 2022 Fulbright Scholar and Professor in Pathology at University of Galway. She was awarded a Science Foundation Ireland Career Development Award in 2018 for her research into the role of nitrosative stress and human endogenous retroviruses (HERV-K) in the development of high grade breast and prostate cancer.  Her current work is focused on elucidating the role of inflammation pathways particularly in the progression of triple negative breast cancer and metastatic prostate cancer. Dr. Glynn has authored over 50 papers in peer reviewed journals and has also received numerous grants from Breast Cancer Now and the Irish Cancer Society. She graduated in 2003 with a BSc in Biotechnology from Dublin City University. After graduation Dr. Glynn served as a research officer at the National Institute for Cellular Biotechnology in Dublin City University where she studied the efficacy of new therapeutics including cholesterol lowering statins on breast cancer and melanoma proliferation and invasion. From 2005 to 2009 Dr. Glynn worked as an NCI Cancer Prevention Fellow in Bethesda Maryland, USA in the Laboratory of Human Carcinogenesis under the mentorship of Dr. Stefan Ambs, studying the role of inflammation pathways in estrogen receptor negative breast cancer progression using an approach combining molecular epidemiology and basic laboratory science. She discovered a novel role for NOS2 in ER negative and basal-like breast cancer progression. Dr. Glynn also discovered a polymorphism in the SOD2 gene predicative of response to cyclophosphamide containing chemotherapeutic regimens in breast cancer cases, receiving an NIH Fellows Award for Research Excellence for this work. In September 2009 Dr. Glynn moved to the Radiation Biology Branch at the NCI, to continue working with Dr. David Wink. During this time she was awarded a Keystone Symposia Scholarship for her work. From September 2010 to December 2014 Dr. Glynn was the Director of Laboratory Research at the Prostate Cancer Institute at NUI Galway (University of Galway).




Research Interests

Inflammation and Breast and Prostate Cancer
Chronic inflammation and infection are major mediators of cancer initiation and cancer progression. Key mediators of inflammation-induced cancer include NFkB, reactive oxygen and nitrogen species, inflammatory cytokines, prostaglandins and specific microRNAs, which in turn exert their effects though changes in cell proliferation, apoptosis, cellular senescence, DNA mutation rates, DNA methylation, cell invasiveness and angiogenesis. Together these species present the ideal targets for early detection, diagnosis, prediction of outcome and also therapeutic targets. Nitric oxide (NO) the product of nitric oxide synthase 2 (NOS2) can influence tumour biology in various and sometimes dichotomous ways. Genetic ablation of NOS2 increases mammary tumour latency and inhibits lung tumour development in mouse models of cancer. These genetic findings demonstrate that NOS2 can have tumour promoting activities. However, NOS2 expression or other forms of NO exposure are not always tumour promoting, and there are many examples where exposure to NO either delayed or inhibited tumour growth and metastasis. Because the effects of NO are strictly concentration-dependent with high concentrations causing cytostasis and apoptosis, at least some of the observed differences are likely explained by a difference in levels of NO exposure. 
The Prostate Cancer – Bone Marrow Mesenchymal Stem Cells Para-endocrine Axis in the metastatic tumor microenvironment
Mesenchymal stem cells (MSC) are multipotent stem cells that can differentiate into osteoblasts, chondrocytes, adipocytes, myocytes and neurons. They can be sourced from the bone marrow (BM) stroma, adipose tissue and dental pulp, and are also found in circulation and are known to home to inflammatory sites. Due to their capacity to home to injured tissue, research has suggested a reparative function for MSC in multiple tissues.  In recent studies it has been shown that MSC can also home to tumour sites and contribute to tumour growth and progression. MSC have been shown to increase the metastatic potential of tumour cells by promoting their migration and invasion as well as having a role in the development of a metastatic niche at the secondary site. BM-MSC may also contribute to tumour growth by differentiating into cancer associated fibroblasts (CAFs), which form part of the tumour microenvironment. Additionally BM-MSCs are intrinsically radio- and chemo-resistant due to a heightened DNA damage response, and thus may contribute to treatment resistance.  Our preliminary studies demonstrate that considerable baseline variations exist in the secretomes of primary BM-MSCs which impact the magnitude of their response to PrCa cell lines, and vice versa. This indicates that inter-patient BM-MSC variation, may impact on tumour microenvironment dynamics, influencing a patients risk of metastasis, and potentially therapeutic response. Our preliminary data has also identified members of the BM-MSC secretome that induce PrCa cell migration in a dose dependant manner, using recombinant growth factors at the concentrations produced by the BM-MSCs.  
 Human Endogenous Retrovirus Activation in Breast and Prostate Cancer
In recent years scientists have observed that several tumor types, including prostate cancer, show increased expression of human endogenous retrovirus (HERV) when compared to normal tissue. Why are these HERVs of interest? The HERVs originated from germ cell infections by exogenous retroviruses during the course of evolution and became incorporated into the human genome. These elements are widely dispersed throughout the genome and are estimated to comprise of greater than >8% of genomic material. Over 20 HERV families have been identified to date, the majority of which are defective due to mutations, deletions or termination signals within coding regions. The HERV-K family, evolutionarily the youngest HERV, is the only HERV family with complete open reading frames for all viral genes, and thus are the most likely to be biologically active and potentially pathogenic. Several questions need to be asked about HERV-K in prostate cancer. Is HERV-K activation a bystander effect in prostate cancer or is it linked to active prostate progression; can it distinguish indolent from aggressive disease? What is the major activator of HERV-K expression in prostate cancer? Does chronic inflammation in prostate tissues lead to the activation of HERV-K expression or does activation of HERV-K lead to tissue inflammation and subsequent carcinogenesis? Pockets of inflammation are often observed in prostate tissues that are not actually cancerous tissue but are thought to be associated with increased risk of prostate cancer.
 
If interested in pursuing applications for PhD funding, please contact me at sharon.glynn@nuigalway.ie 

Research Projects

  Project Start Date End Date
TRIPLE NEGATIVE BREAST CANCER RESEARCH - GUF 01-SEP-18 31-AUG-28
Irish Cancer Society Summer Studentship 2018 05-JUN-18 30-JUL-19
A NEW DIMENSION TO ANCIENT ENEMIES: TARGETING NITROSATIVE STRESS AND HUMAN ENDOGENOUS RETROVIRUS K IMPROVED DIAGNOSIS, CHEMOPREVENTION AND TREATMENT OF HIGH GRADE BREAST AND PROSTATE CANCER 01-FEB-18 31-JAN-22
IRC POSTGRADUATE R DOWNEY F GILES 01-OCT-13 30-SEP-15
DELINEATING THE ROLE OF HUMAN ENDOGENOUS RETROVIRUS K IN CANCER PROGRESSION AND PATIENT OUTCOMES PLANNING GRANT 01-SEP-17 26-FEB-18
MOLECULAR IMPACT OF HUMAN ENDOGENOUS RETROVIRUS K ACTIVATION IN BREAST CANCER 01-SEP-16 31-DEC-20
PRECISE- PRostatE Cancer: Improving active SurveillancE 19-JAN-14 21-APR-15
NOS2&COX2 ACTIVATION OF TLR4 AND EGFR SIGNALLING CAUSES POOR OUTCOME IN OESTROGEN RECEPTOR-NEGATIVE BREAST CANCER VIA PRO SURVIVAL SIGNALS AND IMMUNE POLARISATION S GLYNN 03-MAR-14 31-MAR-18
THE PROSTATE CANCER- BONE MARROW MESENCHYMAL STEM CELLS PARADOCRINE AXIS IN THE METASTATIC TUMOR MICROENVIROMENT SHARON GLYNN FRANK SULLIVAN 31-DEC-13 31-DEC-18

Contract Researchers

  Researcher Name Project Role Funding Body
Dr. Faizan Khan Career Development Award - Role of HERV-K and iNOS in breast and prostate cancer Postdoctoral Researcher

Peer Reviewed Journals

  Year Publication
(2014) 'Prostate Cancer Mediated Differentiation of Bone-Marrow Derived Mesenchymal Stem Cells Facilitates Prostate Cancer Cell Invasive and Migratory Capacity'
Aideen Ryan and Ridge, M. and Ridge, S. M. and Ryan, A. E. and Finn, S. and O'Leary, J. and Giles, F. J. and Sullivan, F. J. and Glynn, S. A. (2014) 'Prostate Cancer Mediated Differentiation of Bone-Marrow Derived Mesenchymal Stem Cells Facilitates Prostate Cancer Cell Invasive and Migratory Capacity'. BJU International, [Details]
(2014) 'Prostate Cancer Mediated Differentiation of Bone-Marrow Derived Mesenchymal Stem Cells Facilitates Prostate Cancer Cell Invasive and Migratory Capacity'
Aideen E Ryan and Ridge, M. and Ridge, S. M. and Ryan, A. E. and Finn, S. and O'Leary, J. and Giles, F. J. and Sullivan, F. J. and Glynn, S. A. (2014) 'Prostate Cancer Mediated Differentiation of Bone-Marrow Derived Mesenchymal Stem Cells Facilitates Prostate Cancer Cell Invasive and Migratory Capacity'. BJU International, [Details]
(2021) 'Nitric Oxide Modulates Metabolic Processes in the Tumor Immune Microenvironment'
Christopher L. McGinity and Erika M. Palmieri and Veena Somasundaram and Dibyangana D. Bhattacharyya and Lisa A. Ridnour and Robert Y. S. Cheng and Aideen E. Ryan and Sharon A. Glynn and Douglas D. Thomas and Katrina M. Miranda and Stephen K. Anderson and Stephen J. Lockett and Daniel W. McVicar and David A. Wink (2021) 'Nitric Oxide Modulates Metabolic Processes in the Tumor Immune Microenvironment'. International Journal of Molecular Sciences, 22 (13) [DOI] [Details]
(2022) 'Interactions between Nitric Oxide and Hyaluronan Implicate the Migration of Breast Cancer Cells'
Alsharabasy AM, Glynn S, Farràs P, Pandit A. (2022) 'Interactions between Nitric Oxide and Hyaluronan Implicate the Migration of Breast Cancer Cells'. Biomacromolecules, [DOI] [Details]
(2022) 'Chronic nitric oxide exposure induces prostate cell carcinogenesis, involving genetic instability and a pro-tumorigenic secretory phenotype'
Burke AJ, McAuliffe JD, Natoni A, Ridge S, Sullivan FJ, Glynn SA. (2022) 'Chronic nitric oxide exposure induces prostate cell carcinogenesis, involving genetic instability and a pro-tumorigenic secretory phenotype'. Nitric Oxide, [DOI] [Details]
(2022) 'Protein nitration induced by Hemin/NO: A complementary mechanism through the catalytic functions of hemin and NO-scavenging'
Alsharabasy AM, Glynn S, Farràs P, Pandit A. (2022) 'Protein nitration induced by Hemin/NO: A complementary mechanism through the catalytic functions of hemin and NO-scavenging'. Nitric Oxide, 124 :49-67 [DOI] [Details]
(2021) 'Ancient Adversary - HERV-K (HML-2) in Cancer'
Dervan E, Bhattacharyya DD, McAuliffe JD, Khan FH, Glynn SA. (2021) 'Ancient Adversary - HERV-K (HML-2) in Cancer'. Frontiers in Oncology, 11 [Details]
(2021) 'Intra-tumour heterogeneity is one of the main sources of inter-observer variation in scoring stromal Tumour Infiltrating Lymphocytes in Triple Negative Breast Cancer'
Darren Kilmartin, Mark O¿Loughlin, Xavier Andreu, Zsuzsanna Bagó-Horváth, Simonetta Bianchi, Ewa Chmielik, Gábor Cserni, Paulo Figueiredo, Giuseppe Floris, Maria Pia Foschini, Anikó Kovács, Janina Kulka, Anne-Vibeke Laenkholm, Inta Liepniece-Karele, Caterina Marchio, Elena Provenzano, Peter Regitnig, Angelika Reiner, Ale¿ Ry¿ka, Anna Sapino, Elisabeth Specht Stovgaard, Cecily Quinn, Vasiliki Zolota, Mark Webber, Sharon A. Glynn, Grace Callagy (2021) 'Intra-tumour heterogeneity is one of the main sources of inter-observer variation in scoring stromal Tumour Infiltrating Lymphocytes in Triple Negative Breast Cancer'. Cancers, [Details]
(2021) 'Role of miRNAs in cervical cancer: A comprehensive novel approach from pathogenesis to therapy'
Abbas M, Mehdi A, Khan FH, Verma S, Ahmad A, Khatoon F, Raza ST, Afreen S, Glynn SA, Mahdi F. (2021) 'Role of miRNAs in cervical cancer: A comprehensive novel approach from pathogenesis to therapy'. Journal Of Gynecology Obstetrics And Human Reproduction, 50 (9) [DOI] [Details]
(2021) 'Nitric Oxide Modulates Metabolic Processes in the Tumor Immune Microenvironment'
McGinity CL, Palmieri EM, Somasundaram V, Bhattacharyya DD, Ridnour LA, Cheng RYS, Ryan AE, Glynn SA, Thomas DD, Miranda KM, Anderson SK, Lockett SJ, McVicar DW, Wink DA. (2021) 'Nitric Oxide Modulates Metabolic Processes in the Tumor Immune Microenvironment'. International Journal Of Molecular Sciences, 22 (11) [DOI] [Details]
(2020) 'The role of extracellular matrix in tumour angiogenesis: the throne has NOx servants'
Alsharabasy, AM;Glynn, SA;Pandit, A (2020) 'The role of extracellular matrix in tumour angiogenesis: the throne has NOx servants'. BIOCHEMICAL SOCIETY TRANSACTIONS, 48 :2539-2555 [DOI] [Details]
(2020) 'The Role of Nitric Oxide in Cancer: Master Regulator or NOt?'
Khan FH;Dervan E;Bhattacharyya DD;McAuliffe JD;Miranda KM;Glynn SA; (2020) 'The Role of Nitric Oxide in Cancer: Master Regulator or NOt?'. International Journal Of Molecular Sciences, 21 (24) [DOI] [Details]
(2020) 'Diabetes mellitus and gender have a negative impact on the outcome of hip fracture surgery - a pilot study'
Galbraith AS;Sanz-Nogués C;Glynn S;Coleman CM;Murphy C; (2020) 'Diabetes mellitus and gender have a negative impact on the outcome of hip fracture surgery - a pilot study'. Journal Of Orthopaedic Research, 38 (4):834-842 [DOI] [ARAN Link] [Details]
(2019) 'Outcome for triple negative breast cancer in a retrospective cohort with an emphasis on response to platinum-based neoadjuvant therapy'
Walsh EM, Shalaby A, O'Loughlin M, Keane N, Webber MJ, Kerin MJ, Keane MM, Glynn SA, Callagy GM. (2019) 'Outcome for triple negative breast cancer in a retrospective cohort with an emphasis on response to platinum-based neoadjuvant therapy'. Breast Cancer Res Treat, 174 (1):1-13 [DOI] [Details]
(2019) 'Emerging novel mechanisms of action for nitric oxide in cancer progression'
Glynn, SA (2019) 'Emerging novel mechanisms of action for nitric oxide in cancer progression'. Current Opinion In Physiology, 9 :18-25 [DOI] [Details]
(2018) 'Reproducibility and predictive value of scoring stromal tumour infiltrating lymphocytes in triple-negative breast cancer: a multi-institutional study'
O'Loughlin, M,Andreu, X,Bianchi, S,Chemielik, E,Cordoba, A,Cserni, G,Figueiredo, P,Floris, G,Foschini, MP,Heikkila, P,Kulka, J,Liepniece-Karele, I,Regitnig, P,Reiner, A,Ryska, A,Sapino, A,Shalaby, A,Stovgaard, ES,Quinn, C,Walsh, EM,Zolota, V,Glynn, SA,Callagy, G (2018) 'Reproducibility and predictive value of scoring stromal tumour infiltrating lymphocytes in triple-negative breast cancer: a multi-institutional study'. Breast Cancer Research And Treatment, 171 (1):1-9 [DOI] [Details]
(2018) 'Secreted factors from metastatic prostate cancer cells stimulate mesenchymal stem cell transition to a pro-tumourigenic 'activated' state that enhances prostate cancer cell migration'
Ridge, SM;Bhattacharyya, D;Dervan, E;Naicker, SD;Burke, AJ;Murphy, JM;O'leary, K;Greene, J;Ryan, AE;Sullivan, FJ;Glynn, SA (2018) 'Secreted factors from metastatic prostate cancer cells stimulate mesenchymal stem cell transition to a pro-tumourigenic 'activated' state that enhances prostate cancer cell migration'. International Journal Of Cancer, 142 (10):2056-2067 [DOI] [Details]
(2017) 'Coexpression of NOS2 and COX2 accelerates tumor growth and reduces survival in estrogen receptor-negative breast cancer'
Basudhar D, Glynn SA, Greer M, Somasundaram V, No JH, Scheiblin DA, Garrido P, Heinz WF, Ryan AE, Weiss JM, Cheng RYS, Ridnour LA, Lockett SJ, McVicar DW, Ambs S, Wink DA. (2017) 'Coexpression of NOS2 and COX2 accelerates tumor growth and reduces survival in estrogen receptor-negative breast cancer'. Proceedings Of The National Academy Of Sciences Of The United States Of America, 114 (49):13030-13035 [DOI] [Details]
(2017) 'Impact of inducible nitric oxide synthase (iNOS) expression on triple negative breast cancer outcome and activation of EGFR and ERK signaling pathways'
Garrido, P,Shalaby, A,Walsh, EM,Keane, N,Webber, M,Keane, MM,Sullivan, FJ,Kerin, MJ,Callagy, G,Ryan, AE,Glynn, SA (2017) 'Impact of inducible nitric oxide synthase (iNOS) expression on triple negative breast cancer outcome and activation of EGFR and ERK signaling pathways'. Oncotarget, 8 (46):80568-80588 [DOI] [Details]
(2017) 'Inflammation and Nitrosative Stress Effects in Ovarian and Prostate Pathology and Carcinogenesis'
Burke AJ, Garrido P, Johnson C, Sullivan FJ, Glynn SA. (2017) 'Inflammation and Nitrosative Stress Effects in Ovarian and Prostate Pathology and Carcinogenesis'. Antioxidants & Redox Signaling, 26 (18):1078-1090 [DOI] [Details]
(2017) 'Mesenchymal stem cells: key players in cancer progression'
Ridge SM, Sullivan FJ, Glynn SA. (2017) 'Mesenchymal stem cells: key players in cancer progression'. Molecular Cancer, 16 (1) [DOI] [Details]
(2017) 'Nitric Oxide Synthase-2-Derived Nitric Oxide Drives Multiple Pathways of Breast Cancer Progression'
Basudhar D, Somasundaram V, de Oliveira GA, Kesarwala A, Heinecke JL, Cheng RY, Glynn SA, Ambs S, Wink DA, Ridnour LA. (2017) 'Nitric Oxide Synthase-2-Derived Nitric Oxide Drives Multiple Pathways of Breast Cancer Progression'. Antioxid Redox Signal, 26 (18):1044-1058 [DOI] [Details]
(2016) 'Can a biobank network and supporting infrastructure enhance Ireland’s ability to attract pharmaceutical research and development and clinical trial opportunities? A pilot survey'
Mee B, Gaffney E, McGarrigle S, Glynn SA, Connolly EM, McCormick PH, Flannery D, O'Connor K, Lawson M, Ryan L, Nugent T, Ward W, Sullivan FJ, Fay J, O'Grady T, Kay E, Eustace J, Burke L, Finn S, Flavin R (2016) 'Can a biobank network and supporting infrastructure enhance Ireland’s ability to attract pharmaceutical research and development and clinical trial opportunities? A pilot survey'. Journal of Biorepository Science for Applied Medicine, 4 :1-8 [DOI] [Details]
(2016) 'Sensitivity Profiles of Human Prostate Cancer Cell Lines to an 80 Kinase Inhibitor Panel'
Burke, AJ;Ali, H;O'Connell, E;Sullivan, FJ;Glynn, SA (2016) 'Sensitivity Profiles of Human Prostate Cancer Cell Lines to an 80 Kinase Inhibitor Panel'. Anticancer Research, 36 (2):633-641 [Details]
(2016) 'Review of Triple Negative Breast Cancer and the Impact of Inducible Nitric Oxide Synthase on Tumor Biology and Patient Outcomes'
Walsh, EM;Keane, MM;Wink, DA;Callagy, G;Glynn, SA (2016) 'Review of Triple Negative Breast Cancer and the Impact of Inducible Nitric Oxide Synthase on Tumor Biology and Patient Outcomes'. Critical reviews in oncogenesis, 21 (5-6):333-351 [DOI] [Details]
(2016) 'An Immune-Inflammation Gene Expression Signature in Prostate Tumors of Smokers'
Prueitt, RL,Wallace, TA,Glynn, SA,Yi, M,Tang, W,Luo, J,Dorsey, TH,Stagliano, KE,Gillespie, JW,Hudson, RS,Terunuma, A,Shoe, JL,Haines, DC,Yfantis, HG,Han, M,Martin, DN,Jordan, SV,Borin, JF,Naslund, MJ,Alexander, RB,Stephens, RM,Loffredo, CA,Lee, DH,Putluri, N,Sreekumar, A,Hurwitz, AA,Ambs, S (2016) 'An Immune-Inflammation Gene Expression Signature in Prostate Tumors of Smokers'. Cancer Research, 76 (5):1055-1065 [DOI] [Details]
(2015) 'Human endogenous retrovirus K and cancer: Innocent bystander or tumorigenic accomplice?'
Downey, RF,Sullivan, FJ,Wang-Johanning, F,Ambs, S,Giles, FJ,Glynn, SA (2015) 'Human endogenous retrovirus K and cancer: Innocent bystander or tumorigenic accomplice?'. International Journal Of Cancer, 137 :1249-1257 [DOI] [Details]
(2015) 'Signaling and stress: The redox landscape in NOS2 biology'
Thomas DD, Heinecke JL, Ridnour LA, Cheng RY, Kesarwala AH, Switzer CH, McVicar DW, Roberts DD, Glynn S, Fukuto JM, Wink DA, Miranda KM. (2015) 'Signaling and stress: The redox landscape in NOS2 biology'. Free Radical Biology And Medicine, 87 :204-225 [DOI] [Details]
(2015) 'A close connection between the PERK and IRE arms of the UPR and the transcriptional regulation of autophagy'
Deegan, S,Koryga, I,Glynn, SA,Gupta, S,Gorman, AM,Samali, A (2015) 'A close connection between the PERK and IRE arms of the UPR and the transcriptional regulation of autophagy'. Biochemical And Biophysical Research Communications, 456 :305-311 [DOI] [Details]
(2014) 'Gene expression profiles of NO- and HNO-donor treated breast cancer cells: insights into tumor response and resistance pathways'
Cheng, RYS;Basudhar, D;Ridnour, LA;Heinecke, JL;Kesarwala, AH;Glynn, S;Switzer, CH;Ambs, S;Miranda, KM;Wink, DA (2014) 'Gene expression profiles of NO- and HNO-donor treated breast cancer cells: insights into tumor response and resistance pathways'. Nitric Oxide, 43 :17-28 [DOI] [Details]
(2014) 'Elevated HERV-K mRNA expression in PBMC is associated with a prostate cancer diagnosis particularly in older men and smokers'
Wallace, TA,Downey, RF,Seufert, CJ,Schetter, A,Dorsey, TH,Johnson, CA,Goldman, R,Loffredo, CA,Yan, PS,Sullivan, FJ,Giles, FJ,Wang-Johanning, F,Ambs, S,Glynn, SA (2014) 'Elevated HERV-K mRNA expression in PBMC is associated with a prostate cancer diagnosis particularly in older men and smokers'. Carcinogenesis, 35 :2074-2083 [DOI] [Details]
(2014) 'Tumor microenvironment-based feed-forward regulation of NOS2 in breast cancer progression'
Heinecke, JL,Ridnour, LA,Cheng, RYS,Switzer, CH,Lizardo, MM,Khanna, C,Glynn, SA,Hussain, SP,Young, HA,Ambs, S,Wink, DA (2014) 'Tumor microenvironment-based feed-forward regulation of NOS2 in breast cancer progression'. Proceedings Of The National Academy Of Sciences Of The United States Of America, 111 :6323-6328 [DOI] [Details]
(2013) 'Molecular Pathways: Toll-like Receptors in the Tumor Microenvironment-Poor Prognosis or New Therapeutic Opportunity'
Ridnour, LA;Cheng, RYS;Switzer, CH;Heinecke, JL;Ambs, S;Glynn, S;Young, HA;Trinchieri, G;Wink, DA (2013) 'Molecular Pathways: Toll-like Receptors in the Tumor Microenvironment-Poor Prognosis or New Therapeutic Opportunity'. Clinical Cancer Research, 19 :1340-1346 [DOI] [Details]
(2013) 'The novel toluidine sulphonamide EL102 shows pre-clinical in vitro and in vivo activity against prostate cancer and circumvents MDR1 resistance'
Toner, AP;McLaughlin, F;Giles, FJ;Sullivan, FJ;O'Connell, E;Carleton, LA;Breen, L;Dunne, G;Gorman, AM;Lewis, JD;Glynn, SA (2013) 'The novel toluidine sulphonamide EL102 shows pre-clinical in vitro and in vivo activity against prostate cancer and circumvents MDR1 resistance'. British Journal Of Cancer, 109 :2131-2141 [DOI] [Details]
(2013) 'The yin and yang of nitric oxide in cancer progression'
Burke, AJ,Sullivan, FJ,Giles, FJ,Glynn, SA (2013) 'The yin and yang of nitric oxide in cancer progression'. Carcinogenesis, 34 (3):503-512 [DOI] [Details]
(2013) 'Development and Progress of Ireland's Biobank Network: Ethical, Legal, and Social Implications (ELSI), Standardized Documentation, Sample and Data Release, and International Perspective'
Mee B, Gaffney E, Glynn SA, Donatello S, Carroll P, Connolly E, Garrigle SM, Boyle T, Flannery D, Sullivan FJ, McCormick P, Griffin G, Muldoon C, Fay J, O'Grady T, Kay E, Eustace J, Burke L, Sheikh AA, Finn S, Flavin R, Giles FJ. (2013) 'Development and Progress of Ireland's Biobank Network: Ethical, Legal, and Social Implications (ELSI), Standardized Documentation, Sample and Data Release, and International Perspective'. Biopreservation And Biobanking, 11 (1):3-11 [Details]
(2013) 'MicroRNA-106b-25 cluster expression is associated with early disease recurrence and targets caspase-7 and focal adhesion in human prostate cancer'
Hudson RS, Yi M, Esposito D, Glynn SA, Starks AM, Yang Y, Schetter AJ, Watkins SK, Hurwitz AA, Dorsey TH, Stephens RM, Croce CM, Ambs S. (2013) 'MicroRNA-106b-25 cluster expression is associated with early disease recurrence and targets caspase-7 and focal adhesion in human prostate cancer'. Oncogene, 32 (35):4139-4147 [Details]
(2012) 'S-Nitrosation Mediates Multiple Pathways That Lead to Tumor Progression in Estrogen Receptor-Negative Breast Cancer'
Switzer CH, Ridnour LA, Cheng R, Heinecke J, Burke A, Glynn S, Ambs S, Wink DA (2012) 'S-Nitrosation Mediates Multiple Pathways That Lead to Tumor Progression in Estrogen Receptor-Negative Breast Cancer'. Forum on immunopathological diseases and therapeutics, 3 (2):117-124 [DOI] [Details]
(2012) 'Immunotherapeutic potential of anti-human endogenous retrovirus-K envelope protein antibodies in targeting breast tumors'
Wang-Johanning F, Rycaj K, Plummer JB, Li M, Yin B, Frerich K, Garza JG, Shen J, Lin K, Yan P, Glynn SA, Dorsey TH, Hunt KK, Ambs S, Johanning GL (2012) 'Immunotherapeutic potential of anti-human endogenous retrovirus-K envelope protein antibodies in targeting breast tumors'. Journal Of The National Cancer Institute, 104 (3):189-210 [DOI] [Details]
(2012) 'Dithiolethiones inhibit NF-κB activity via covalent modification in human estrogen receptor-negative breast cancer'
Switzer CH, Cheng RY, Ridnour LA, Murray MC, Tazzari V, Sparatore A, Del Soldato P, Hines HB, Glynn SA, Ambs S, Wink DA (2012) 'Dithiolethiones inhibit NF-κB activity via covalent modification in human estrogen receptor-negative breast cancer'. Cancer Research, 72 (9):2394-2404 [DOI] [Details]
(2012) 'Ets-1 is a transcriptional mediator of oncogenic nitric oxide signaling in estrogen receptor-negative breast cancer'
Switzer, CH,Cheng, RYS,Ridnour, LA,Glynn, SA,Ambs, S,Wink, DA (2012) 'Ets-1 is a transcriptional mediator of oncogenic nitric oxide signaling in estrogen receptor-negative breast cancer'. Breast Cancer Research, 14 (5) [DOI] [Details]
(2012) 'S-Nitrosylation of EGFR and Src activates an oncogenic signaling network in human basal-like breast cancer'
Switzer S, Glynn SA, Cheng RYS, Ridnour LA,Green JE, Ambs A,Wink DA (2012) 'S-Nitrosylation of EGFR and Src activates an oncogenic signaling network in human basal-like breast cancer'. Molecular Cancer Research, 10 (9):1203-1215 [Details]
(2012) 'Nitric oxide synthase and breast cancer: role of TIMP-1 in NO-mediated Akt activation'
Ridnour LA, Barasch KM, Windhausen AN, Dorsey TH, Lizardo MM, Yfantis HG, Lee DH, Switzer CH, Cheng RY, Heinecke JL, Brueggemann E, Hines HB, Khanna C, Glynn SA, Ambs S, Wink DA (2012) 'Nitric oxide synthase and breast cancer: role of TIMP-1 in NO-mediated Akt activation'. Plos One, 7 (9) [DOI] [Details]
(2011) 'Candidate pathways linking inducible nitric oxide synthase to a basal-like transcription pattern and tumor progression in human breast cancer'
Ambs, S;Glynn, SA (2011) 'Candidate pathways linking inducible nitric oxide synthase to a basal-like transcription pattern and tumor progression in human breast cancer'. Cell Cycle, 10 :619-624 [DOI] [Details]
(2011) 'The specificity of nitroxyl chemistry is unique among nitrogen oxides in biological systems'
Flores-Santana W, Salmon DJ, Donzelli S, Switzer CH, Basudhar D, Ridnour L, Cheng R, Glynn SA, Paolocci N, Fukuto JM, Miranda KM, Wink DA (2011) 'The specificity of nitroxyl chemistry is unique among nitrogen oxides in biological systems'. Antioxidants & Redox Signaling, 14 (9):1659-1674 [DOI] [Details]
(2011) 'Nitric oxide and protein phosphatase 2A provide novel therapeutic opportunities in ER-negative breast cancer'
Switzer, C.H., Glynn, S.A., Ridnour, L.A., Cheng, R.Y.-S., Vitek, M.P., Ambs, S., Wink, D.A. (2011) 'Nitric oxide and protein phosphatase 2A provide novel therapeutic opportunities in ER-negative breast cancer'. Trends in Pharmacological Sciences, 32 (11):644-651 [Details]
(2011) 'Expression of Human Endogenous Retrovirus Type K Envelope Protein is a Novel Candidate Prognostic Marker for Human Breast Cancer'
Zhao J, Rycaj K, Geng S, Li M, Plummer JB, Yin B, Liu H, Xu X, Zhang Y, Yan Y, Glynn SA, Dorsey TH, Ambs S, Johanning GL, Gu L, Wang-Johanning F (2011) 'Expression of Human Endogenous Retrovirus Type K Envelope Protein is a Novel Candidate Prognostic Marker for Human Breast Cancer'. Genes & Cancer, 2 (9):914-922 [DOI] [Details]
(2010) 'COX-2 activation is associated with Akt phosphorylation and poor survival in ER-negative, HER2-positive breast cancer'
Glynn SA, Prueitt RL, Ridnour LA, Boersma BJ, Dorsey TM, Wink DA, Goodman JE, Yfantis HG, Lee DH, Ambs S (2010) 'COX-2 activation is associated with Akt phosphorylation and poor survival in ER-negative, HER2-positive breast cancer'. BMC Cancer, 10 [DOI] [Details]
(2010) 'Increased NOS2 predicts poor survival in estrogen receptor-negative breast cancer patients'
Glynn SA, Boersma BJ, Dorsey TH, Yi M, Yfantis HG, Ridnour LA, Martin DN, Switzer CH, Hudson RS, Wink DA, Lee DH, Stephens RM, Ambs S (2010) 'Increased NOS2 predicts poor survival in estrogen receptor-negative breast cancer patients'. J Clin Invest, 120 (11):3843-3854 [DOI] [Details]
(2009) 'A mitochondrial target sequence polymorphism in manganese superoxide dismutase predicts inferior survival in breast cancer patients treated with cyclophosphamide'
Glynn SA, Boersma BJ, Howe TM, Edvardsen H, Geisler SB, Goodman JE, Ridnour LA, Lønning PE, Børresen-Dale AL, Naume B, Kristensen VN, Chanock SJ, Wink DA, Ambs S (2009) 'A mitochondrial target sequence polymorphism in manganese superoxide dismutase predicts inferior survival in breast cancer patients treated with cyclophosphamide'. Clinical Cancer Research, 15 (12):4165-4173 [DOI] [Details]
(2008) 'The 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors, simvastatin, lovastatin and mevastatin inhibit proliferation and invasion of melanoma cells'
Glynn SA, O'Sullivan D, Eustace AJ, Clynes M, O'Donovan N (2008) 'The 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors, simvastatin, lovastatin and mevastatin inhibit proliferation and invasion of melanoma cells'. BMC Cancer, 8 [DOI] [Details]
(2007) 'Purification and identification of a 7.6-kDa protein in media conditioned by superinvasive cancer cells'
Dowling P, Maurya P, Meleady P, Glynn SA, Dowd AJ, Henry M, Clynes M (2007) 'Purification and identification of a 7.6-kDa protein in media conditioned by superinvasive cancer cells'. Anticancer Research, 27 (3A):1309-1317 [Details]
(2007) 'Proteomic analysis of isolated membrane fractions from superinvasive cancer cells'
Dowling P, Meleady P, Dowd A, Henry M, Glynn S, Clynes M (2007) 'Proteomic analysis of isolated membrane fractions from superinvasive cancer cells'. Biochimica Et Biophysica Acta, 1774 (1):93-101 [DOI] [Details]
(2006) 'Low adhesiveness coupled with high superinvasiveness in vitro predicts the in vivo metastatic potential of a mouse mammary adenocarcinoma cell line'
Glynn SA, Adams A, Gibson B, Cronin D, Harmey JH, Clynes M (2006) 'Low adhesiveness coupled with high superinvasiveness in vitro predicts the in vivo metastatic potential of a mouse mammary adenocarcinoma cell line'. Anticancer Research, 26 (2A):1001-1010 [Details]
(2004) 'A new superinvasive in vitro phenotype induced by selection of human breast carcinoma cells with the chemotherapeutic drugs paclitaxel and doxorubicin'
Glynn SA, Gammell P, Heenan M, O'Connor R, Liang Y, Keenan J, Clynes M (2004) 'A new superinvasive in vitro phenotype induced by selection of human breast carcinoma cells with the chemotherapeutic drugs paclitaxel and doxorubicin'. Br J Cancer, 91 (10):1800-1807 [DOI] [Details]
(2004) 'Expression and prognostic relevance of Mcl-1 in breast cancer'
O'Driscoll L, Cronin D, Kennedy SM, Purcell R, Linehan R, Glynn S, Larkin A, Scanlon K, McDermott EW, Hill AD, O'Higgins NJ, Parkinson M, Clynes M (2004) 'Expression and prognostic relevance of Mcl-1 in breast cancer'. Anticancer Research, 24 (2A):473-482 [Details]
(2003) 'Lack of prognostic significance of survivin, survivin-deltaEx3, survivin-2B, galectin-3, bag-1, bax-alpha and MRP-1 mRNAs in breast cancer'
O'Driscoll L, Linehan R, M Kennedy S, Cronin D, Purcell R, Glynn S, W McDermott E, D Hill A, J O'Higgins N, Parkinson M, Clynes M (2003) 'Lack of prognostic significance of survivin, survivin-deltaEx3, survivin-2B, galectin-3, bag-1, bax-alpha and MRP-1 mRNAs in breast cancer'. Cancer Lett, 201 (2):225-236 [Details]

Book Chapters

  Year Publication
(2020) 'A review of RKIP promotion of tumor progression, metastasis and poor outcome in multiple solid tumor types'
Dervan E, Bhattacharyya D, Glynn SA (2020) 'A review of RKIP promotion of tumor progression, metastasis and poor outcome in multiple solid tumor types' In: Prognostic and Therapeutic Applications of RKIP in Cancer. San Diego, USA: Elsevier. [Details]
(2018) 'Nitric Oxide and Nitric Oxide Donors in Preclinical Studies of Breast and Prostate Cancer'
Garrido, P;Walsh, EM;Glynn, SA (2018) 'Nitric Oxide and Nitric Oxide Donors in Preclinical Studies of Breast and Prostate Cancer' In: Nitric Oxide (Donor/Induced) In Chemosensitization. :57-70 LONDON: ACADEMIC PRESS LTD-ELSEVIER SCIENCE LTD. [DOI] [Details]
(2015) 'Mechanisms of Nitric Oxide Dependent Regulation of Tumour Invasion and Metastasis'
Ryan AE, Burke AJ, Sullivan FJ, Glynn SA (2015) 'Mechanisms of Nitric Oxide Dependent Regulation of Tumour Invasion and Metastasis' In: NO and Cancer - Prognosis, Prevention and Therapy. :49-64 USA: Springer. [DOI] [Details]
(2010) 'Nitric Oxide and Cancer: An Overview'
Cheng R, Ridnour L, Glynn S, Switzer CH, Flores-Santana W, Hussain Perwez, Thomas DD, Ambs S, Harris CC, Wink D (2010) 'Nitric Oxide and Cancer: An Overview' In: Nitric Oxide (NO) and Cancer: Prognosis, Prevention, and Therapy. :3-20 New York, USA: Springer. [DOI] [Details]
(2010) 'NITRIC OXIDE AND REDOX INFLAMMATION IN CANCER'
Cheng, R; Glynn, S; Flores-Santana, W; Switzer, C; Ridnour, L; Wink, DA (2010) 'NITRIC OXIDE AND REDOX INFLAMMATION IN CANCER' In: ADVANCES IN MOLECULAR TOXICOLOGY, VOL 4. :157-182 Netherlands: ELSEVIER SCIENCE BV. [DOI] [Details]

Conference Publications

  Year Publication
(2022) 44th Annual San Antonio Breast Cancer Symposium
Sharon A Glynn, Dibyangana Bhattacharyya, Shauna Lambe, Emma Kerr, Simon McDade, Faizan H Khan, Eoin Dervan, Feng Wang-Johanning, Sean Hynes, Grace Callagy (2022) Human endogenous retrovirus-K (HERV-K) is aberrantly expressed in triple negative breast cancer (TNBC) and associated with increased distant metastasis: Impact of HERV-K knockdown on gene expression patterns and invasive potential of mesenchymal TNBC . In: Cancer Research, 82, 4 eds. 44th Annual San Antonio Breast Cancer Symposium , 07-DEC-21 - 10-DEC-21 [Details]
(2021) European Urological Association Annual Congress 2021
E.C. Roche, J. McAuliffe, M. Hegazy , K. Daly, A. McDermott, C. Dowling, P. O¿Malley, S.A. Glynn, G.C. Durkan (2021) Exploring human endogenous retrovirus K as a discriminatory biomarker in the diagnosis of indolent versus aggressive prostate cancer . In: European Urology Open Science, Vol 31 eds. European Urological Association Annual Congress 2021 , 09-JUL-21 - 13-JUL-21 [Details]
(2020) 42nd Annual San Antonio Breast Cancer Symposium
Walsh EM, O'Loughlin M, Shalaby A, Webber M, Kerin MJ, Glynn SA, Callagy GC, Keane MM (2020) Pathological complete response after carboplatin-based neoadjuvant chemotherapy in triple negative breast cancer: The importance of stromal tumor infiltrating lymphocytes as a predictive biomarker . In: Cancer Research eds. 42nd Annual San Antonio Breast Cancer Symposium , 08-DEC-20 - 11-DEC-20 [DOI] [Details]
(2019) Annual Meeting of the American Society of Clinical Oncology
Walsh, EM,O'Loughlin, M,Shalaby, A,Webber, M,Kerin, MJ,Glynn, SA,Callagy, G,Keane, MM (2019) The role of stromal tumor infiltrating lymphocytes (sTILs) as a predictive biomarker for carboplatin-based neoadjuvant chemotherapy (NACT) in triple-negative breast cancer (TNBC) . In: JOURNAL OF CLINICAL ONCOLOGY eds. Annual Meeting of the American Society of Clinical Oncology USA, , 01-JUN-19 - 04-JUN-19 [Details]
(2018) European Orthopaedic Research Society (EORS) 2018 Meeting
Galbraith, AS,Glynn, S,Coleman, CM,Murphy, CG (2018) Investigating the Impact of Diabetes Mellitus on the Outcomes of Hip Fracture Surgery . In: Orthopedic Proceedings eds. European Orthopaedic Research Society (EORS) 2018 Meeting Ireland, , pp.201-202 [Details]
(2018) Sir Peter Freyer Surgical Symposium
Bhattacharyya, DD,Dervan, E,Bharadwaj, K,Glynn, S (2018) Consequences of Human Endogenous Retrovirus-K (HERV-K) Protein Expression in Breast Cancer . In: IRISH JOURNAL OF MEDICAL SCIENCE eds. Sir Peter Freyer Surgical Symposium Galway, Ireland, , pp.147-148 [Details]
(2018) Annual Meeting of the American Association for Cancer Research
Basudhar, D,Glynn, S,Greer, M,Somasundaram, V,No, JH,Scheiblin, DA,Garrido, P,Heinz, WF,Ryan, AE,Weiss, JM,Cheng, RY,Ridnour, LA,Lockett, SJ,McVicar, DW,Ambs, S,Wink, DA (2018) Role of NOS2-COX2 crosstalk in tumor microenvironment of estrogen receptor-negative breast cancer and its therapeutic implications . In: Cancer Research eds. Annual Meeting of the American Association for Cancer Research USA, [DOI] [Details]
(2017) 29th European Congress of Pathology
A. Shalaby, E. Walsh, S. Glynn, G. Callagy (2017) Association between stromal tumour lymphocyte infiltration in the needle core biopsies and paired post-neoadjuvant chemotherapy resection specimens in triple negative breast cancer . In: VIRCHOWS ARCHIV eds. 29th European Congress of Pathology [Details]
(2017) 29th European Congress of Pathology
Shalaby, A,Walsh, E,Glynn, S,Callagy, G (2017) Stromal tumour lymphocyte infiltration as a prognostic tool in triple negative breast cancer . In: VIRCHOWS ARCHIV eds. 29th European Congress of Pathology Amsterdam, Netherlands, [Details]
(2017) Annual Meeting of the American-Association-for-Cancer-Research (AACR)
O'Leary, K, Ridge, S, Watson, W, Perry, A, Finn, S, McDermott, R, Glynn, SA (2017) Paraendocrine interactions between bone marrow mesenchymal stem cells and prostate cancer cells: impact on tumor cell invasive and proliferative capacity . In: Cancer Research, 77, S13, 5920 eds. Annual Meeting of the American-Association-for-Cancer-Research (AACR) [Details]
(2016) 2016 Genitourinary Cancers Symposium
John Patrick Greene , Orla Casey , Karen O'Leary , Ciara Fahey , Suzanne Bracken , Sharon A. GlynnAntoinette Perry , William Watson , Stephen Finn , Ray McDermott (2016) The Irish Programme for Stratified Prostate Cancer Therapy (iPROSPECT) . In: Journal of Clinical Oncology eds. 2016 Genitourinary Cancers Symposium [Details]
(2016) Regulatory effects of NOS2-COX2 in breast cancer progression in tumor microenvironment
Basudhar, D,Somasundaram, V,Glynn, S,Ridnour, LA,Cheng, RY,Wink, DA (2016) INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE Regulatory effects of NOS2-COX2 in breast cancer progression in tumor microenvironment , pp.81-81 [Details]
(2016) 38th Annual CTRC-AACR San Antonio Breast Cancer Symposium
Glynn, S,Garrrido-Cuesta, P,Wink, D,Ridnour, L,Ambs, S,Keane, M,Walsh, E,Callagy, G (2016) NOS2&COX2 activation of TLR4 & EGFR signalling causes poor outcome in oestrogen receptor-negative breast cancer via pro-survival signals and immune polarisation . In: CANCER RESEARCH eds. 38th Annual CTRC-AACR San Antonio Breast Cancer Symposium San Antonio, TX, USA, [Details]
(2016) 38th Annual CTRC-AACR San Antonio Breast Cancer Symposium
Walsh, EM,Shalaby, A,Murillo, LS,Webber, MJ,Kerin, MJ,Glynn, SA,Callagy, GM,Ingoldsby, H,Keane, MM (2016) Subtyping of triple negative breast cancer by a novel immunohistochemistry panel: Assessing the correlation between subtypes and clinical outcomes . In: CANCER RESEARCH, 76,4, P06-05-09 eds. 38th Annual CTRC-AACR San Antonio Breast Cancer Symposium San Antonio, TX, USA, , 08-DEC-15 - 12-DEC-15 [DOI] [Details]
(2015) AACR 106th Annual Meeting 2015
Elaine M. Walsh, Aliaa Shalaby, Laura Murillo, Mark Webber, Michael Kerin, Sharon Glynn, Grace Callaghy, Helen Ingoldsby and Maccon Keane (2015) Identification of triple negative breast cancer (TNBC) subtypes by an immunohistochemistry (IHC) panel with impact on clinical outcomes . In: Cancer Research eds. AACR 106th Annual Meeting 2015 [Details]
(2015) IV International Workshop on Nitric Oxide in Cancer
David A. Wink, Lisa A. Ridnour, Robert Cheng, Christopher W. Switzer, Sharon Glynn, Stefan Ambs (2015) The Oncogenic Properties Of The Redox Inflamma-tory Protein Inducible Nitric Oxide Synthase In ER(-)Breast Cancer . In: Redox Biology eds. IV International Workshop on Nitric Oxide in Cancer [Details]
(2015) AACR 106th Annual Meeting 2015
Husnain Ali, Amy Burke, Enda O'Connell, Frank Sullivan, Frank Giles and Sharon Glynn (2015) GSK3¿/ß inhibition as a drug target in prostate cancer . In: Cancer Research eds. AACR 106th Annual Meeting 2015 [Details]
(2015) 106th Annual Meeting of the American-Association-for-Cancer-Research (AACR)
Downey, R,Murillo, L,McHale, T,Wallace, T,Seufert, C,Schetter, A,Dorsey, T,Johnson, C,Goldman, R,Loffredo, C,Yan, PS,Sullivan, F,Giles, F,Wang-Johanning, F,Ambs, S,Glynn, S (2015) Human endogenous retrovirus K expression as a possible adjunct to PSA in the diagnosis of prostate cancer . In: CANCER RESEARCH, 75, 15, 536 eds. 106th Annual Meeting of the American-Association-for-Cancer-Research (AACR) [DOI] [Details]
(2014) 50th Annual Meeting of the American-Society-of-Clinical-Oncology
Glynn, SA,Wallace, T,Downey, R,Seufert, C,Schetter, A,Giles, FJ,Sullivan, F,Dorsey, T,Goldman, R,Yan, PS,Wang-Johanning, F,Ambs, S (2014) The potential of peripheral blood HERV-K expression as a biomarker for diagnosis with prostate cancer in older men . In: JOURNAL OF CLINICAL ONCOLOGY eds. 50th Annual Meeting of the American-Society-of-Clinical-Oncology Chicago, IL, USA, [Details]
(2014) Annual Scientific Meeting of the British-Association-of-Urological-Surgeons (BAUS)
Glynn, A,Downey, R,Wallace, T,Sullivan, FJ,Giles, FJ,Walsh, K,Durkan, G,Roger, E,Wang-Johanning, F,Ambs, S,Glynn, SA (2014) Elevated HERV-K Expression in PBMC is Associated with a Diagnosis of Prostate Cancer among Older Men and Current Smokers . In: BJU INTERNATIONAL, 113, S5, 28-28 eds. Annual Scientific Meeting of the British-Association-of-Urological-Surgeons (BAUS) Liverpool, England, [Details]
(2014) Annual Scientific Meeting of the Irish-Society-of-Urology
Sullivan, FJ,Walsh, K,Rogers, E,Durkan, G,O'Malley, P,Hayes, DB,O'Boyle, G,Zuchora, A,Woulfe, P,Glynn, S (2014) LDR Brachytherapy in the Management of Patients wih Localized Prostate Cancer: Update of the Galway Experience in the first 536 cases, 2007-2012 . In: BJU INTERNATIONAL, 114, SI2, 24-24 eds. Annual Scientific Meeting of the Irish-Society-of-Urology Killarney, Ireland, [Details]
(2014) 50th Annual Meeting of the American-Society-of-Clinical-Oncology
Toner, AP,Giles, FJ,Sullivan, F,Harte, E,Carleton, LA,Gorman, AM,Lewis, J,Glynn, SA (2014) Further preclinical assessment of compound EL102 in the treatment of prostate cancer . In: JOURNAL OF CLINICAL ONCOLOGY eds. 50th Annual Meeting of the American-Society-of-Clinical-Oncology [Details]
(2014) Annual Scientific Meeting of the British-Association-of-Urological-Surgeons (BAUS)
Ridge, M,Ridge, SM,Ryan, AE,Finn, S,O'Leary, J,Giles, FJ,Sullivan, FJ,Glynn, SA (2014) Prostate Cancer Mediated Differentiation of Bone-Marrow Derived Mesenchymal Stem Cells Facilitates Prostate Cancer Cell Invasive and Migratory Capacity . In: BJU INTERNATIONAL, 113, S5, 28-28 eds. Annual Scientific Meeting of the British-Association-of-Urological-Surgeons (BAUS) Liverpool, England, [Details]
(2014) Annual Scientific Meeting of the Irish-Society-of-Urology
Downey, RF,Wallace, T,Sullivan, FJ,Wang-Johanning, F,Walsh, K,Durkan, G,Rogers, E,Goldman, R,Ambs, S,Glynn, SA (2014) Human Endogenous Retrovirus K Expression Predicts a Prostate Cancer Diagnosis . In: BJU INTERNATIONAL, 114, SI2, 19-19 eds. Annual Scientific Meeting of the Irish-Society-of-Urology [Details]
(2014) Annual Scientific Meeting of the Irish-Society-of-Urology
Ridge, S,O'Leary, K,Shaw, G,Murphy, M,Walsh, K,Durkan, G,Rogers, E,Sullivan, FJ,Glynn, SA (2014) Bone Marrow Derived-Mesenchymal Stem Cell Reprogramming by Prostate Cancer Cells to Promote Prostate Cancer Progression . In: BJU INTERNATIONAL, 114, SI2, 18-19 eds. Annual Scientific Meeting of the Irish-Society-of-Urology Killarney, Ireland, [Details]
(2014) Irish Association for Cancer Research
Ali, H; Burke, A; O’Connell, E; Giles, FJ; Sullivan, F; Glynn, S. (2014) Novel Kinase Inhibitors as Drug Targets in Prostate Cancer Irish Association for Cancer Research [Details]
(2014) Irish Association for Cancer Research
Toner, AP; Giles, FJ; Carleton, LA; O’Connell, E; Harte, E; Breen, L; Dunne. G; Clynes, M; Lewis, JD; Gorman, AM; Sullivan, FJ; Glynn, SA. (2014) Characterisation of a new class of prostate cancer chemotherapeutics Irish Association for Cancer Research [Details]
(2013) Association of Surgeons in Training Conference
Elma Anna O'Reilly, Shiva Sharma, Michele Harrison, Karolina Weiner-Gorzel, Ciara Kelly, Aoife Maguire, Janet McCormack, Susie Conlon, Susan Aherne, Caitlin Beggan, Richard Bambury, Tiffany Dorsey, Stefan Ambs, Darran O'Connor, John McCaffrey, Reem Salman, Sharon A. Glynn, Fiona Furlong, Amanda McCann, Malcolm Kell, Cecily Quinn, Rut Klinger (2013) Low nuclear MAD2 expression is associated with of lack of response to chemotherapy and radiotherapy in oestrogen receptor negative breast cancer patients . In: International Journal of Surgery eds. Association of Surgeons in Training Conference [Details]
(2013) Surgical Conference
Elma O'Reilly, Shiva Sharma, Rut Klinger, Michele Harrison, Tomas Lyons, Stefan Ambs, John McCaffrey, Michael Joe Duffy, John Crown, Susie Conlon, Cecily Quinn, Sharon Glynn, Amanda McCann (2013) Low MAD2 protein expression is a predictor of poor outcome after chemotherapy and radiotherapy in oestrogen receptor negative breast cancer patients . In: European Journal of Surgical Oncology eds. Surgical Conference [Details]
(2013) Irish Association for Cancer Research Annual Meeting
EAO Reilly, S Sharma, R Klinger, L Gubbins, C Kelly, T Lyons, A Maguire, S Aherne, M Barry, S Conlon, J McCaffrey, M Harrison, S Glynn, A McCann, M Kell (2013) Low MAD2 Protein Expression is a Predictor of Poor Outcome After Chemotherapy & Radiotherapy in Oestrogen Receptor Negative Breast Cancer . In: IRISH JOURNAL OF MEDICAL SCIENCE eds. Irish Association for Cancer Research Annual Meeting [Details]
(2013) THE AMERICAN CHEMICAL SOCIETY
David A Wink, Christopher W Switzer, Julie Heincke, Lisa A Ridnour, Robert Cheng, Sharon Glynn, Stefan Ambs (2013) Oncogenic properties of nitrosation in ERa (-) breast cancer . In: Journal of the American Chemical Society eds. THE AMERICAN CHEMICAL SOCIETY [Details]
(2013) Academic Screening Workshop
Toner, AP; Burke, A; Giles, FJ; Harte, E; Carleton, LA; O’Connell, E; Lewis, JD; Glynn, SA. (2013) Preclicincal analysis of EL102, a novel compound proposed for the treatment of prostate cancer Academic Screening Workshop Baltimore, MD, USA, [Details]
(2012) AACR Special Conference on Advances in Prostate Cancer Research
Aidan Toner, Fiona McLaughlin, Jill McMahon, Francis J. Giles, Frank Sullivan, Laura Breen, Martin Clynes, Joe D. Lewis and Sharon A. Glynn (2012) EL102: A novel dual inhibitor which demonstrates additive prostate cancer inhibitory activity in combination with docetaxel in vitro and in mouse models . In: Cancer Research eds. AACR Special Conference on Advances in Prostate Cancer Research [Details]
(2013) British Association of Urological Surgeons AGM
Toner, AP; McLaughlin, F; Giles, FJ; Sullivan, FJ; O’Connell, E; Carleton, LA; Breen, L; Gorman , AM; Lewis, JD and Glynn, SA. (2013) Introducing Novel Toluidine Sulphonamide EL102: A Potential Chemotherapeutic In Prostate Cancer British Association of Urological Surgeons AGM [Details]
(2012) AACR Special Conference on Advances in Prostate Cancer Research
Ronan Downey, Amy Burke, Francis J. Giles, Frank Sullivan, Feng Wang-Johanning, Blanaid Mee, Eoin Gaffney and Sharon Anneve Glynn (2012) Human endogenous retrovirus activation in prostate cancer: Association with disease progression . In: Cancer Research eds. AACR Special Conference on Advances in Prostate Cancer Research [Details]
(2012) Royal Academy of Medicine in Ireland Annual Meeting
Burke, AJ; O'Connell, E; Miranda, KM; Giles, FJ; Sullivan, F; Glynn, SA (2012) Nitric Oxide and its effects on cellular proliferation and phenotype in prostate cancer Royal Academy of Medicine in Ireland Annual Meeting NUI Galway, Ireland, [Details]
(2012) 48th Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO)
Glynn, SA,Toner, A,Lewis, J,Sullivan, F,Breen, L,Clynes, M,Giles, FJ (2012) Prostate cancer inhibitory activity of a novel dual inhibitor, EL102, in combination with docetaxel, and its effects on MDR1-mediated drug resistance in vitro 48th Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO) Chicago, IL, USA, [Details]
(2010) American Chemical Society Annual Meeting
David Wink, Christopher Switzer, Wilmarie Flores-Santana, Sharon Glynn, Lisa Ridnour, Robert Cheng (2010) Chemical biology of NO in mechanisms of inflammation . In: Journal of the American Chemical Society eds. American Chemical Society Annual Meeting [Details]
(2008) 31st Annual San Antonio Breast Cancer Symposium
Glynn, SA, Boersma, BJ, Howe, TM, Ridnour, L, Wink, D, Edvardsen, H, Borresen-Dale, AL, Ambs, S (2008) A functional SNP in the leader sequence of the manganese superoxide dimutase gene is a predictor of breast cancer patient survival and response to chemotherapy . In: CANCER RESEARCH, 69, 2 eds. 31st Annual San Antonio Breast Cancer Symposium San Antonio, Texas, USA, , pp.366S-367S [Details]
(2008) Biotechnology Conference
S Germano, M Clynes, S Kennedy, JP Mehta, E Kenny, E Ryan, P Doolan, P Gaminell, H Joyce, M Perez de Villarreall, A Hill, B O'Daly, R Linehan, D Cronin, C Daly, S Glynn, L O'Driscoll (2008) NOVEL ROLE OF NEURONAL CALCIUM SENSOR-1 (NCS-1) AS PROGNOSTIC FACTOR AND THERAPEUTIC TARGET IN BREAST CANCER . In: Anticancer Research eds. Biotechnology Conference [Details]
(2008) 31st Annual San Antonio Breast Cancer Symposium
Glynn, SA; Boersma, BJ; Howe, TM; Ridnour, L; Wink, D; Yi, M; Yvantis, H; Ambs, S (2008) Aberrant inducible nitric oxide synthase expression predicts poor survival in estrogen receptor negative breast cancer, and is associated with a gene expression signature similar to that of basal-like breast cancer . In: Cancer Research, 69, 2 eds. 31st Annual San Antonio Breast Cancer Symposium San Antonio, Texas, USA, , pp.320s-321s [Details]
(2007) AACR Annual Meeting
S Glynn, B Boersma, T Howe, H Yfantis, S Ambs (2007) NOS2 expression in estrogen receptor-negative breast cancer predicts survival . In: Cancer Research eds. AACR Annual Meeting [Details]
(2007) Biotechnology Conference
A Larkin, D O'Sullivan, H Joyce, S Glynn, M Clynes (2007) Generation and preliminary characterisation of MAbs raised to the invasive breast cell line, MDA-MB-435-SF . In: Anticancer Research eds. Biotechnology Conference [Details]
(2007) 1st International Conference on Nitric Oxide and Cancer
Glynn, S, Boersma, B, Martin, D, Howe, T, Ridnour, L, Wink, D, Yi, M, Stephens, R, Yfantis, H, Ambs, S (2007) iNOS expression is associated with basal-like breast cancer phenotype and predicts poor survival in ERneg breast cancer . In: NITRIC OXIDE-BIOLOGY AND CHEMISTRY, 17, 1, S17 eds. 1st International Conference on Nitric Oxide and Cancer Paris, France, [DOI] [Details]

Other Journals

  Year Publication
(2022) 'NOS2 and COX2 Blockade Limits TNBC Disease Progression and Alters CD8+ T Cell Spatial Orientation and Density'
Veena Somasundaram, Lisa A Ridnour, Robert YS Cheng, Abigail J Walke, Noemi Kedei, Dibyangana D Bhattacharyya, Adelaide L Wink, Elijah F Edmondson, Donna Butcher, Andrew Warner, Tiffany H Dorsey, David A Scheiblin, William Heinz, Richard J Bryant, Robert Kinders, Stanley Lipkowitz, Stephen TC Wong, Milind Pore, Stephen M Hewitt, Daniel W McVicar, Stephen K Anderson, Jenny Chang, Sharon A Glynn, Stefan Ambs, Stephen J Lockett, David A Wink (2022) 'NOS2 and COX2 Blockade Limits TNBC Disease Progression and Alters CD8+ T Cell Spatial Orientation and Density' bioRxiv, . [DOI] [Details]

Abstract

  Year Publication
(2014) Nitric oxide and breast cancer disease progression: Role of timp-1 in pro-survival signaling.
Ridnour, L,Glynn, S,Barasch, K,Windhausen, A,Sneha, D,Dorsey, T,Yfantis, H,Lee, DH,Heinecke, J,Brueggemann, E,Lizardo, M,Khanna, C,Ambs, S,Wink, D,Hines, H,Switzer, C (2014) Nitric oxide and breast cancer disease progression: Role of timp-1 in pro-survival signaling. Abstract [DOI] [Details]
(2013) Cellular fate assessment in triple negative breast cancer (TNBC) predictchemoresponse and patient outcome.
O'Reilly, EA,Sharma, S,Klinger, R,Harrison, M,Weiner-Gorzel, K,Kelly, C,Maguire, A,McCormack, J,Conlon, S,Aherne, S,Beggan, C,Bambury, R,Lyons, T,Dorsey, TH,Ambs, S,O'Connor, D,Quinn, C,McCaffrey, J,Salman, R,Glynn, SA,Furlong, F,McCann, A,Kell, M (2013) Cellular fate assessment in triple negative breast cancer (TNBC) predictchemoresponse and patient outcome. Abstract [Details]
(2010) NITRIC OXIDE AND NITROSATIVE STRESS IN INFLAMMATION.
David Wink, C Switzer, W Flores-Santana, S Glynn, R Cheng (2010) NITRIC OXIDE AND NITROSATIVE STRESS IN INFLAMMATION. Basic & Clinical Pharmacology & Toxicology Abstract [Details]

ANET/COS

  Year Publication
(2017) Association between stromal tumour lymphocyte infiltration in the needle core biopsies and paired post-neoadjuvant chemotherapy resection specimens in triple negative breast cancer.
Shalaby, A,Glynn, S,Callagy, G (2017) Association between stromal tumour lymphocyte infiltration in the needle core biopsies and paired post-neoadjuvant chemotherapy resection specimens in triple negative breast cancer. VIRCHOWS ARCHIVIVES ANET/COS [Details]

Honours and Awards

  Year Title Awarding Body
2022 Fulbright Scholar Award Fulbright Commission
2018 Science Foundation Ireland Career Development Award Science Foundation Ireland
2015 Breast Cancer Now PhD Grant Breast Cancer Now
2013 Breast Cancer Campaign Project Grant Breast Cancer Campaign
2013 Irish Cancer Society Prostate Cancer Transformative Programme Grant Irish Cancer Society
2010 Keystone Symposia Scholarship Keystone Symposia
2010 Prostate Cancer Research Award NUI Galway
2009 NIH Fellows Award for Research Excellence National Institutes of Health
2005 All-Ireland Cancer Consortium NCI Cancer Prevention Fellowship NCI, USA & HRB, Ireland

Professional Associations

  Association Function From / To
European Association for Cancer Research Member 01-JAN-11 /
International Society for Nitric Oxide and Cancer Secretary 01-JAN-19 /
American Association for Cancer Research Member 01-JAN-08 /
Irish Association for Cancer Research Member 01-SEP-97 /

Committees

  Committee Function From / To
CMNHS Research and Graduate Studies Member /
Academic Council Member 01-SEP-18 /
SOM Athena Swan Committee Member 01-FEB-18 /
CMNHS Research Ethics Committee Co-Chair 01-FEB-18 /
SOM Research Committee Chair 01-MAY-16 /

Employment

  Employer Position From / To
NUI Galway Lecturer Above the Bar 01-JAN-15 / 30-SEP-20
NUI Galway Senior Lecturer 01-OCT-20 /
National University of Ireland Galway Director of Laboratory Research, PCI 01-SEP-10 / 31-DEC-14
National Cancer Institute, USA Visiting Fellow 01-JUN-09 / 31-AUG-10
National Cancer Institute, USA NCI Cancer Prevention Fellow 01-SEP-05 / 31-MAY-09

Education

  Year Institution Qualification Subject
2019 NUI Galway PgCert Teaching and Learning in Higher Education
2006 University College Dublin Master in Public Health Public Health
2003 Dublin City University PhD Biotechnology
1997 Dublin City University BSc (Hons) Biotechnology

Community Engagement

  Title Type From / To
Outreach Soapbox Science 01-JUL-17 /
Outreach Cancer Research & Awareness Evening The Future of Cancer Research - Early Detection And Prevention 11-FEB-16 /

Recent Postgraduate Students

  Graduation Name Degree Primary Supervisor
2016 Amy Burke PhD Y
2017 Carol Johnson PhD Y
2016 Husnain Ali PhD Y
2015 Aidan Toner PhD Y
2016 Ronan Downey PhD Y
2016 Sarah Ridge PhD Y

Modules Taught

  Term/Year Module Title Module Code Subject / Desc
Since 2017 Elements in Pathology PA405
Since 2015 Health and Disease I MD201 Medicine - 15 ECTs module shared between Pathology, Public Health and Bacteriology.. Coordinate the pathology component worth 10 ECTs.
Since 2015 Health and Disease II MD302 Medicine - 15 ECTs module shared between Pathology, Public Health and Bacteriology.
2012-2014 Cancer Research: Technologies and Skills BI462 Methodologies for cancer research
Since 2012 Clinical Oncology, Haematology BI461: Lung and genitourinary cancers

Internal Collaborators

  Name Description of Collaboration
Prof. Grace Callagy
Dr. Aideen Ryan

External Collaborators

  Name Organisation / Institute Country Description of Collaboration
Dr. Feng Wang-Johanning SRI International U.S.A.
Dr. Stefan Ambs Natonal Cancer Institute U.S.A.
Dr. David Wink National Cancer Institute U.S.A.