Medicine

Prof Sanbing Shen

B.Sc, M.Sc, Ph.D

Biography

Prof. Shen is leading a research group working on animal model and human induced pluripotent stem cell (iPSC) models of brain disorders at REMEDI, School of Medicine, NUI Galway. His team has collaborated with Irish clinicians and now generated iPSCs from a total of ~50 individuals of healthy controls, and patients with Autistic Spectrum Disorders (ASD), Fragile X Syndrome (FXS), Amyotrophic Lateral Sclerosis (ALS), Retinitis Pigmentosa (RP), and Long QT syndrome (LQTS), all of which are associated with specific genetic lesions. Their new project will also derive iPSCs from patients with Epilepsy. They are currently differentiating the iPSCs into astrocytes, neurons and cardiomyocytes, and phenotype them to establish human disease models on dish. They also discovered that ULK4 can be a rare risk factor for neurodevelopmental and neuropsychiatric disorders. They are working on the Ulk4 hypomorph mouse model and discovered its role in neuritogenesis, neurogenesis, ciliogenesis and anxiety behavior. Their recent publications include: 1. Madill M, McDonagh K, Ma J, Vajda A, McLoughlin P, O'Brien T, Hardiman O, Shen S*. Amyotrophic Lateral Sclerosis patient iPSC-derived astrocytes impair autophagy via non-cell autonomous mechanisms. Mol. Brain. 2017 Jun 13;10(1):22. 2. Sotthibundhu A, McDonagh K, Klawiter A, Thompson K, Dockery P, Devine M, Kunath T, O’Brien T, Barry F, Shen S*. 2016. Rapamycin Regulates Autophagy and Cell Adhesion in Induced Pluripotent Stem Cells. Stem Cell Res. Ther. 2016 Nov 15;7(1):166.3. Liu M, Guan Z, Shen Q, Flinter F, Domínguez L, Ahn JW, Collier DA, O'Brien T, Shen S*. Ulk4 Regulates Neural Stem Cell Pool. Stem Cells. 2016 Sep;34(9):2318-31. 4. Liu M, Guan ZL, Shen Q, Lalor P, Fitzgerald U, O’Brien T, Dockery P, Shen S*. Ulk4 is essential for ciliogenesis and CSF flow. 2016, J Neurosci. 2016 Jul 20;36(29):7589-600. 5. Dominguez L, Schlosser G; Shen S*. 2015. Expression of a novel serine/threonine kinase gene, Ulk4, in neural progenitors during Xenopus laevis forebrain development. Neuroscience, 2015 Apr 2;290:61-79.6. Lang B, Pu J, Hunter I, Liu M, Martin-Granados C, Reilly TJ, Gao GD, Guan ZL, Li W, Shi Y, He G, He L, Stefánsson H, St Clair D, Blackwood DH, McCaig CD, Shen S*. 2014 Recurrent deletions of ULK4 in schizophrenia: a novel gene crucial for neuronal elongation, branching and motility J Cell Sci 127:630-40.

Book Chapters

	Year	Publication
	(2014)	'Molecular Pathways in Autistic Spectrum Disorders' Gallagher L, Shen S, Anney R (2014) 'Molecular Pathways in Autistic Spectrum Disorders' In: -. -: -. [Details]
	(2006)	'Modification and amplification of yeast artificial chromosomes' Shen S, Harmar AJ, Hastie N. (2006) 'Modification and amplification of yeast artificial chromosomes' In: YAC Protocols*. US: Humana Press. [Details]
	(1987)	'Micromanipulation' Shen S, Yan SY (1987) 'Micromanipulation' In: Encyclopedia of China. 显微操作,《中国大百科全书》第一版. 外文名称*. China: Chinese: 中国大百科全书出版社. [Details]

Peer Reviewed Journals

	Year	Publication
	(2016)	'Ulk4 Regulates Neural Stem Cell Pool' Liu, M;Guan, ZL;Shen, Q;Flinter, F;Dominguez, L;Ahn, JW;Collier, DA;O'Brien, T;Shen, SB (2016) 'Ulk4 Regulates Neural Stem Cell Pool'. Stem Cells (Dayton, Ohio), 34 :2318-2331 [DOI] [Details]
	(2017)	'Multiple roles of Ulk4 in neurogenesis and brain function' Liu M, Xu P, O'Brien T, Shen S. (2017) 'Multiple roles of Ulk4 in neurogenesis and brain function'. Neurogenetics, 23 (4(1):e1313646) [DOI] [Details]
	(2017)	'Amyotrophic lateral sclerosis patient iPSC-derived astrocytes impair autophagy via non-cell autonomous mechanisms' Madill, M;McDonagh, K;Ma, J;Vajda, A;McLoughlin, P;O'Brien, T;Hardiman, O;Shen, SB (2017) 'Amyotrophic lateral sclerosis patient iPSC-derived astrocytes impair autophagy via non-cell autonomous mechanisms'. Molecular Brain, 10 [DOI] [Details]
	(2018)	'Ulk4 deficiency leads to hypomyelination in mice' Liu, M,Xu, P,Guan, ZL,Qian, XH,Dockery, P,Fitzgerald, U,O'Brien, T,Shen, SB (2018) 'Ulk4 deficiency leads to hypomyelination in mice'. Glia, 66 :175-190 [DOI] [Details]
	(2015)	'Molecular Pathways in Autistic Spectrum Disorders' Gallagher, L,Shen, SB,Anney, R,Leboyer, M,Chaste, P (2015) 'Molecular Pathways in Autistic Spectrum Disorders'. Autism Spectrum Disorders: Phenotypes, Mechanisms And Treatments, 180 :97-112 [DOI] [Details]
	(2016)	'Ulk4 Regulates Neural Stem Cell Pool' Liu, M,Guan, ZL,Shen, Q,Flinter, F,Dominguez, L,Ahn, JW,Collier, DA,O'Brien, T,Shen, SB (2016) 'Ulk4 Regulates Neural Stem Cell Pool'. Stem Cells, 34 :2318-2331 [DOI] [Details]
	(2016)	'Ulk4 Is Essential for Ciliogenesis and CSF Flow' Liu, M,Guan, ZL,Shen, Q,Lalor, P,Fitzgerald, U,O'Brien, T,Dockery, P,Shen, SB (2016) 'Ulk4 Is Essential for Ciliogenesis and CSF Flow'. Journal Of Neuroscience, 36 :7589-7600 [DOI] [Details]
	(2016)	'Rapamycin regulates autophagy and cell adhesion in induced pluripotent stem cells' Sotthibundhu, A,McDonagh, K,von Kriegsheim, A,Garcia-Munoz, A,Klawiter, A,Thompson, K,Chauhan, KD,Krawczyk, J,McInerney, V,Dockery, P,Devine, MJ,Kunath, T,Barry, F,O'Brien, T,Shen, S (2016) 'Rapamycin regulates autophagy and cell adhesion in induced pluripotent stem cells'. Stem Cell Research & Therapy, 7 [DOI] [Details]
	(2017)	'Amyotrophic lateral sclerosis patient iPSC-derived astrocytes impair autophagy via non-cell autonomous mechanisms' Madill, M,McDonagh, K,Ma, J,Vajda, A,McLoughlin, P,O'Brien, T,Hardiman, O,Shen, SB (2017) 'Amyotrophic lateral sclerosis patient iPSC-derived astrocytes impair autophagy via non-cell autonomous mechanisms'. Molecular Brain, 10 [DOI] [Details]
	(2015)	'Altered functional brain network connectivity and glutamate system function in transgenic mice expressing truncated Disrupted-in-Schizophrenia 1' Dawson, N,Kurihara, M,Thomson, DM,Winchester, CL,McVie, A,Hedde, JR,Randall, AD,Shen, S,Seymour, PA,Hughes, ZA,Dunlop, J,Brown, JT,Brandon, NJ,Morris, BJ,Pratt, JA (2015) 'Altered functional brain network connectivity and glutamate system function in transgenic mice expressing truncated Disrupted-in-Schizophrenia 1'. Translational Psychiatry, 5 [DOI] [Details]
	(2015)	'Natural and Synthetic Materials for Self-Renewal, Long-Term Maintenance, and Differentiation of Induced Pluripotent Stem Cells' Dzhoyashvili, NA,Shen, SB,Rochev, YA (2015) 'Natural and Synthetic Materials for Self-Renewal, Long-Term Maintenance, and Differentiation of Induced Pluripotent Stem Cells'. Advanced Healthcare Materials, 4 :2342-2359 [DOI] [Details]
	(2015)	'Natural and Synthetic Materials for Self-Renewal, Long-Term Maintenance, and Differentiation of Induced Pluripotent Stem Cells' Dzhoyashvili NA, Shen S, Rochev YA. (2015) 'Natural and Synthetic Materials for Self-Renewal, Long-Term Maintenance, and Differentiation of Induced Pluripotent Stem Cells'. Advanced Healthcare Materials, [DOI] [Details]
	(2015)	'Expression of a novel Serine?Threonin kinase gene, Ulk4, in neural progenitors during Xenopus laevis forebrain development' Dominguez, L,Schlosser, G,Shen, S (2015) 'Expression of a novel Serine?Threonin kinase gene, Ulk4, in neural progenitors during Xenopus laevis forebrain development'. Neuroscience, 290 :61-79 [DOI] [Details]
	(2014)	'THE EXPRESSION AND ROLES OF NDE1 AND NDEL1 IN THE ADULT MAMMALIAN CENTRAL NERVOUS SYSTEM' Pei, Z,Lang, B,Fragoso, YD,Shearer, KD,Zhao, L,Mccaffery, PJA,Shen, S,Ding, YQ,McCaig, CD,Collinson, JM (2014) 'THE EXPRESSION AND ROLES OF NDE1 AND NDEL1 IN THE ADULT MAMMALIAN CENTRAL NERVOUS SYSTEM'. Neuroscience, 271 :119-136 [DOI] [Details]
	(2014)	'Overexpression of Wnt5a in mouse epidermis causes no psoriasis phenotype but an impairment of hair follicle anagen development' Zhu, XM,Wu, YM,Huang, SX,Chen, YW,Tao, YX,Wang, YS,He, SG,Shen, SB,Wu, J,Guo, XZ,Li, BJ,He, L,Ma, G (2014) 'Overexpression of Wnt5a in mouse epidermis causes no psoriasis phenotype but an impairment of hair follicle anagen development'. Exp Dermatol, 23 :926-928 [DOI] [Details]
	(2014)	'Constitutive Activation of Ectodermal beta-Catenin Induces Ectopic Outgrowths at Various Positions in Mouse Embryo and Affects Abdominal Ventral Body Wall Closure' Zhu, XM,Huang, SX,Zhang, LL,Wu, YM,Chen, YW,Tao, YX,Wang, YS,He, SG,Shen, SB,Wu, J,Li, BJ,Guo, XZ,He, L,Ma, G (2014) 'Constitutive Activation of Ectodermal beta-Catenin Induces Ectopic Outgrowths at Various Positions in Mouse Embryo and Affects Abdominal Ventral Body Wall Closure'. Plos One, 9 [DOI] [Details]
	(2014)	'Recurrent deletions of ULK4 in schizophrenia: a gene crucial for neuritogenesis and neuronal motility' Lang, B,Pu, J,Hunter, I,Liu, M,Martin-Granados, C,Reilly, TJ,Gao, GD,Guan, ZL,Li, WD,Shi, YY,He, G,He, L,Stefansson, H,St Clair, D,Blackwood, DH,McCaig, CD,Shen, SB (2014) 'Recurrent deletions of ULK4 in schizophrenia: a gene crucial for neuritogenesis and neuronal motility'. Journal Of Cell Science, 127 :630-640 [DOI] [Details]
	(2014)	'Over-expression of Wnt5a in mouse epidermis causes no psoriasis phenotype but an impairment of hair follicle anagen development' Zhu X, Wu Y, Huang S, Chen Y, Tao Y, Wang Y, He S, Shen S, Wu J, Guo X, Li B, He L, Ma G (2014) 'Over-expression of Wnt5a in mouse epidermis causes no psoriasis phenotype but an impairment of hair follicle anagen development'. Exp Dermatol, [DOI] [Details]
	(2014)	'The expression and roles of Nde1 and Ndel1 in the adult mammalian central nervous system' Pei, Z.a and Lang, B.a and Fragoso, Y.D.a b and Shearer, K.D.a and Zhao, L.a and Mccaffery, P.J.A.a and Shen, S.a c and Ding, Y.Q.d and McCaig, C.D.a and Collinson, J.M.a (2014) 'The expression and roles of Nde1 and Ndel1 in the adult mammalian central nervous system'. Neuroscience, 271 :119-136 [Details]
	(2014)	'Upregulation of autophagy by rapamycin induces spontaneous formation of uniform embryoid bodies and accelerates differentiation of human induced pluripotent stem cells' Sotthibundhu A, McDonagh K, Klawiter A, Thompson K, Dockery P, Devine M, Kunath T, O’Brien T, Barry F, Shen S* (2014) 'Upregulation of autophagy by rapamycin induces spontaneous formation of uniform embryoid bodies and accelerates differentiation of human induced pluripotent stem cells'. Autophagy, [Details]
	(2014)	'Expression of a novel serine/threonine kinase gene, Ulk4, in neural progenitors during Xenopus laevis forebrain development' Dominguez L, Schlosser G; Shen S* (2014) 'Expression of a novel serine/threonine kinase gene, Ulk4, in neural progenitors during Xenopus laevis forebrain development'. Neuroscience, [Details]
	(2014)	'Altered brain network connectivity and glutamate system functioning in transgenic mice expressing truncated Disrupted-in-Schizophrenia 1' Dawson N, Kurihara M, Thomson DM, Winchester CL, McVie A, Randall A, Shen S, Seymour PA, Hughes ZA, Dunlop J, Brown J, Brandon NJ, Morris BJ, Pratt JA. (2014) 'Altered brain network connectivity and glutamate system functioning in transgenic mice expressing truncated Disrupted-in-Schizophrenia 1'. Translational Psychiatry, [Details]
	(2013)	'PACAP and PAC1 receptor in brain development and behavior' Shen, SB,Gehlert, DR,Collier, DA (2013) 'PACAP and PAC1 receptor in brain development and behavior'. Neuropeptides, 47 :421-430 [DOI] [Details]
	(2012)	'Progress on stem cell research towards the treatment of Parkinson's disease' Gibson, S.A.a and Gao, G.-D.b and McDonagh, K.c and Shen, S.c (2012) 'Progress on stem cell research towards the treatment of Parkinson's disease'. Stem Cell Research and Therapy, 3 (2) [Details]
	(2012)	'HDAC9 is implicated in schizophrenia and expressed specifically in post-mitotic neurons but not in adult neural stem cells' Lang B, Alrahbeni TM, Clair DS, Blackwood DH, McCaig CD, Shen S (2012) 'HDAC9 is implicated in schizophrenia and expressed specifically in post-mitotic neurons but not in adult neural stem cells'. Stem Cells and Development, 1 (1):31-41 [Details]
	(2011)	'A zinc finger protein Zfp521 directs neural differentiation and beyond' Shen, S. and Pu, J. and Lang, B. and McCaig, C.D. (2011) 'A zinc finger protein Zfp521 directs neural differentiation and beyond'. Stem Cell Research and Therapy, 2 (2) [Details]
	(2010)	'Chemical synthesis and biological activities of 3-alkyl pyridinium polymeric analogues of marine toxins' Houssen, W.E.a b and Lu, Z.b and Edrada-Ebel, R.c and Chatzi, C.a f and Tucker, S.J.a and SepÄiÄ‡, K.d and Turk, T.d and Zovko, A.d and Shen, S.a and Mancini, I.e and Scott, R.H.a and Jaspars, M.b (2010) 'Chemical synthesis and biological activities of 3-alkyl pyridinium polymeric analogues of marine toxins'. Journal of Chemical Biology, 3 (3):113-125 [Details]
	(2010)	'GABAergic amacrine cells and visual function are reduced in PAC1 transgenic mice' Lang, B.a and Zhao, L.a and Cai, L.b and McKie, L.c and Forrester, J.V.a and McCaig, C.D.a and Jackson, I.J.c and Shen, S.a (2010) 'GABAergic amacrine cells and visual function are reduced in PAC1 transgenic mice'. Neuropharmacology, 58 (1):215-225 [Details]
	(2010)	'Expression of a mutant retinoic acid receptor Î² alters lineage differentiation in mouse embryonic stem cells' Chatzi, C.a and Van Den Brink, C.E.b and Van Der Saag, P.T.b and McCaig, C.D.a and Shen, S.a (2010) 'Expression of a mutant retinoic acid receptor Î² alters lineage differentiation in mouse embryonic stem cells'. Stem Cells and Development, 19 (7):951-960 [Details]
	(2009)	'Deregulation of EIF4E: A novel mechanism for autism' Neves-Pereira, M.a and MÃ¼ller, B.b and Massie, D.c and Williams, J.H.G.a and O'Brien, P.C.M.d and Hughes, A.a and Shen, S.-B.b and St. Clair, D.a and Miedzybrodzka, Z.a c (2009) 'Deregulation of EIF4E: A novel mechanism for autism'. Journal of Medical Genetics, 46 (11):759-765 [Details]
	(2009)	'Derivation of homogeneous GABAergic neurons from mouse embryonic stem cells' Chatzi, C. and Scott, R.H. and Pu, J. and Lang, B. and Nakamoto, C. and McCaig, C.D. and Shen, S. (2009) 'Derivation of homogeneous GABAergic neurons from mouse embryonic stem cells'. Experimental Neurology, 217 (2):407-416 [Details]
	(2008)	'Schizophrenia-related neural and behavioral phenotypes in transgenic mice expressing truncated Disc1' Shen, S.a and Lang, B.a and Nakamoto, C.a and Zhang, F.a and Pu, J.a and Kuan, S.-L.a and Chatzi, C.a and He, S.b and Mackie, I.c and Brandon, N.J.d and Marquis, K.L.d and Day, M.e and Hurko, O.e f and McCaig, C.D.a and Riedel, G.a and St Clair, D.a (2008) 'Schizophrenia-related neural and behavioral phenotypes in transgenic mice expressing truncated Disc1'. Journal of Neuroscience, 28 (43):10893-10904 [Details]
	(2006)	'Increased expression of the 5-HT transporter confers a low-anxiety phenotype linked to decreased 5-HT transmission' Jennings, K.A.a and Loder, M.K.b and Sheward, W.J.b and Pei, Q.a and Deacon, R.M.J.c and Benson, M.A.a and Olverman, H.J.b and Hastie, N.D.d and Harmar, A.J.b and Shen, S.b f and Sharp, T.a e (2006) 'Increased expression of the 5-HT transporter confers a low-anxiety phenotype linked to decreased 5-HT transmission'. Journal of Neuroscience, 26 (35):8955-8964 [Details]
	(2006)	'Modification and amplification of yeast artificial chromosomes' Shen, S. and Harmar, A. and Hastie, N. (2006) 'Modification and amplification of yeast artificial chromosomes'. Methods in molecular biology (Clifton, N.J.), 349 :67-74 [Details]
	(2006)	'Expression of the human PAC1 receptor leads to dose-dependent hydrocephalus-related abnormalities in mice' Lang, B.a and Song, B.a and Davidson, W.a and MacKenzie, A.a and Smith, N.b and McCaig, C.D.a and Harmar, A.J.c and Shen, S.a d (2006) 'Expression of the human PAC1 receptor leads to dose-dependent hydrocephalus-related abnormalities in mice'. Journal of Clinical Investigation, 116 (7):1924-1934 [Details]
	(2004)	'Mice overexpressing human caspase 3 appear phenotypically normal but exhibit increased apoptosis and larger lesion volumes in response to transient focal cerebral ischaemia' Kerr, L.E.a and McGregor, A.L.a and Amet, L.E.A.a and Asada, T.a e and Spratt, C.a and Allsopp, T.E.a c and Harmar, A.J.b and Shen, S.b d and Carlson, G.a and Logan, N.a and Kelly, J.S.a and Sharkey, J.a (2004) 'Mice overexpressing human caspase 3 appear phenotypically normal but exhibit increased apoptosis and larger lesion volumes in response to transient focal cerebral ischaemia'. Cell Death and Differentiation, 11 (10):1102-1111 [Details]
	(2004)	'Overexpression of the 5-Hydroxytryptamine Transporter Gene: Effect on Pulmonary Hemodynamics and Hypoxia-Induced Pulmonary Hypertension' MacLean, M.R.a d and Deuchar, G.A.b and Hicks, M.N.b and Morecroft, I.a and Shen, S.c and Sheward, J.c and Colston, J.a and Loughlin, L.a and Nilsen, M.a and Dempsie, Y.a and Harmar, A.c (2004) 'Overexpression of the 5-Hydroxytryptamine Transporter Gene: Effect on Pulmonary Hemodynamics and Hypoxia-Induced Pulmonary Hypertension'. Circulation, 109 (17):2150-2155 [Details]
	(2004)	'Transgenic approach reveals expression of the VPAC2 receptor in phenotypically defined neurons in the mouse suprachiasmatic nucleus and in its efferent target sites' KallÃ³, I.a b and Kalamatianos, T.a and Wiltshire, N.a and Shen, S.c and Sheward, W.J.c and Harmar, A.J.c and Coen, C.W.a (2004) 'Transgenic approach reveals expression of the VPAC2 receptor in phenotypically defined neurons in the mouse suprachiasmatic nucleus and in its efferent target sites'. European Journal of Neuroscience, 19 (8):2201-2211 [Details]
	(2003)	'The mouse VPAC2 receptor confers suprachiasmatic nuclei cellular rhythmicity and responsiveness to vasoactive intestinal polypeptide in vitro' Cutler, D.J.a and Haraura, M.a and Reed, H.E.a and Shen, S.b and Sheward, W.J.b and Morrison, C.F.b and Marston, H.M.b c and Harmar, A.J.b and Piggins, H.D.a (2003) 'The mouse VPAC2 receptor confers suprachiasmatic nuclei cellular rhythmicity and responsiveness to vasoactive intestinal polypeptide in vitro'. European Journal of Neuroscience, 17 (2):197-204 [Details]
	(2003)	'A hVIPR transgene as a novel tool for the analysis of circadian function in the mouse suprachiasmatic nucleus' King, V.M.a and Chahad-Ehlers, S.a and Shen, S.b and Harmar, A.J.b and Maywood, E.S.a c and Hastings, M.H.a c (2003) 'A hVIPR transgene as a novel tool for the analysis of circadian function in the mouse suprachiasmatic nucleus'. European Journal of Neuroscience, 17 (4):822-832 [Details]
	(2003)	'Erratum: A hVIPR transgene as a novel tool for the analysis of circadian function in the mouse suprachiasmatic nucleus (European Journal of Neuroscience (2003) 17 (822-832))' King, V.M. and Chahad-Ehlers, S. and Shen, S. and Harmar, A.J. and Maywood, E.S. and Hastings, M.H. (2003) 'Erratum: A hVIPR transgene as a novel tool for the analysis of circadian function in the mouse suprachiasmatic nucleus (European Journal of Neuroscience (2003) 17 (822-832))'. European Journal of Neuroscience, 17 (11) [Details]
	(2002)	'The VPAC2 receptor is essential for circadian function in the mouse suprachiasmatic nuclei' Harmar, A.J.a and Marston, H.M.a b and Shen, S.a and Spratt, C.a b and West, K.M.a c and Sheward, W.Johna and Morrison, C.F.a and Dorin, J.R.c and Piggins, H.D.d and Reubi, J.-C.e and Kelly, J.S.a b and Maywood, E.S.f and Hastings, M.H.f (2002) 'The VPAC2 receptor is essential for circadian function in the mouse suprachiasmatic nuclei'. Cell, 109 (4):497-508 [Details]
	(2001)	'Enhanced delayed-type hypersensitivity and diminished immediate-type hypersensitivity in mice lacking the inducible VPAC2 receptor for vasoactive intestinal peptide' Goetzl, E.J.a c and Voice, J.K.a and Shen, S.b and Dorsam, G.a and Kong, Y.a and West, K.M.b and Morrison, C.F.b and Harmar, A.J.b (2001) 'Enhanced delayed-type hypersensitivity and diminished immediate-type hypersensitivity in mice lacking the inducible VPAC2 receptor for vasoactive intestinal peptide'. Proceedings of the National Academy of Sciences of the United States of America, 98 (24):13854-13859 [Details]
	(2000)	'Refined mapping of the human serotonin transporter (SLC6A4) gene within 17q11 adjacent to the CPD and NF1 genes' Shen, S.a d and Battersby, S.a and Weaver, M.b and Clark, E.a and Stephens, K.b c and Harmar, A.J.a (2000) 'Refined mapping of the human serotonin transporter (SLC6A4) gene within 17q11 adjacent to the CPD and NF1 genes'. European Journal of Human Genetics, 8 (1):75-78 [Details]
	(2000)	'Overexpression of the human VPAC2 receptor in the suprachiasmatic nucleus alters the circadian phenotype of mice' Shen, S.a and Spratt, C.a b and Sheward, W.J.a and Kallo, I.c and West, K.a and Morrison, C.F.a and Coen, C.W.c and Marston, H.M.a b and Harmar, A.J.a (2000) 'Overexpression of the human VPAC2 receptor in the suprachiasmatic nucleus alters the circadian phenotype of mice'. Proceedings of the National Academy of Sciences of the United States of America, 97 (21):11575-11580 [Details]
	(1999)	'Structure of the human VIPR2 gene for vasoactive intestinal peptide receptor type 2' Lutz, E.M.a and Shen, S.b and Mackay, M.b and West, K.b and Harmar, A.J.b (1999) 'Structure of the human VIPR2 gene for vasoactive intestinal peptide receptor type 2'. FEBS Letters, 458 (2):197-203 [Details]
	(1999)	'Presence of multiple functional polyadenylation signals and a single nucleotide polymorphism in the 3' untranslated region of the human serotonin transporter gene' Battersby, S.a e and Ogilvie, A.D.a and Blackwood, D.H.R.b and Shen, S.a and Muqit, M.M.K.a and Muir, W.J.b and Teague, P.c and Goodwin, G.M.d and Harmar, A.J.a (1999) 'Presence of multiple functional polyadenylation signals and a single nucleotide polymorphism in the 3' untranslated region of the human serotonin transporter gene'. Journal of Neurochemistry, 72 (4):1384-1388 [Details]
	(1995)	'Regulation of Oct-4 Gene expression during differentiation of EC cells' Schoorlemmer J, Jonk L, Shen S, Vanpuijenbroek A, Feijen A and Kruijer W. (1995) 'Regulation of Oct-4 Gene expression during differentiation of EC cells'. Molecular biology reports, 21 :129-40 [Details]
	(1994)	'Ectopic expression of Hoxb-8 causes duplication of the ZPA in the forelimb and homeotic transformation of axial structures' CharitÃ©, J.a and De Graaff, W.a and Shen, S.a b and Deschamps, J.a (1994) 'Ectopic expression of Hoxb-8 causes duplication of the ZPA in the forelimb and homeotic transformation of axial structures'. Cell, 78 (4):589-601 [Details]
	(1993)	'Dominant negative retinoic acid receptor Î²' Shen, S. and Van Der Saag, P.T. and Kruijer, W. (1993) 'Dominant negative retinoic acid receptor Î²'. Mechanisms of Development, 40 (3):177-189 [Details]
	(1992)	'A preliminary report on pluripotent embryonic stem cells in pig embryos and generation of two chimeric pigs by blastocyst injection. 猪的胚胎嵌合试验中若干技术环节的研究(初报)' 林大光,经荣斌,孙长美,成勇,崔恒宓,李碧春,龚允成,杜淼,邹贤刚,沈三兵 (S Shen),陆德裕 (1992) 'A preliminary report on pluripotent embryonic stem cells in pig embryos and generation of two chimeric pigs by blastocyst injection. 猪的胚胎嵌合试验中若干技术环节的研究(初报)'. 江苏农学院学报, [Details]
	(1992)	'Embryonic stem cells stably transfected with mRARÎ²2-lacZ exhibit specific expression in chimeric embryos' Shen, S. and Van Den Brink, C.E. and Kruijer, W. and Van Der Saag, P.T. (1992) 'Embryonic stem cells stably transfected with mRARÎ²2-lacZ exhibit specific expression in chimeric embryos'. International Journal of Developmental Biology, 36 (4):465-476 [Details]
	(1991)	'Mouse and human retinoic acid receptor beta 2 promoters: sequence comparison and localization of retinoic acid responsiveness' Shen, S. and Kruyt, F.A. and den Hertog, J. and van der Saag, P.T. and Kruijer, W. (1991) 'Mouse and human retinoic acid receptor beta 2 promoters: sequence comparison and localization of retinoic acid responsiveness'. DNA sequence : the journal of DNA sequencing and mapping, 2 (2):111-119 [Details]
	(1990)	'Characteristics of embryonic stem cell differentiation: A comparison with two embryonal carcinoma cell lines' Mummery, C.L. and Feyen, A. and Freund, E. and Shen, S. (1990) 'Characteristics of embryonic stem cell differentiation: A comparison with two embryonal carcinoma cell lines'. Cell Differentiation and Development, 30 (3):195-206 [Details]
	(1990)	'Developmental potency of mouse primitive ectoderm cells, embryonic ectoderm cells and primordial germ cells after blastocyst injection' Shen S* (1990) 'Developmental potency of mouse primitive ectoderm cells, embryonic ectoderm cells and primordial germ cells after blastocyst injection'. Cell Research, 1 :53-65 [Details]
	(1990)	'The study of the developmental potential of early embryonic cells of rabbit' Du M, Lu DY, Shen S, Huang GP, Zhou XG (1990) 'The study of the developmental potential of early embryonic cells of rabbit'. Shi Yan Sheng Wu Xue Bao, 23 :477-85 [Details]
	(1989)	'Study on the developmental potential of rabbit embryonic cells through construction of chimera' Lu DY, Tu M, Shen S, Zhou X, Huang G (1989) 'Study on the developmental potential of rabbit embryonic cells through construction of chimera'. Cell Differentiation and Development, 27 [Details]
	(1988)	'Developmental potential of mouse primitive ectoderm cells following blastocyst injection' Shen SB, Tu M and Lu DY (1988) 'Developmental potential of mouse primitive ectoderm cells following blastocyst injection'. Shi Yan Sheng Wu Xue Bao*, 21 (2):189-99 [Details]
	(1988)	'Construction of chimeric rabbits by blastocyst injection of ICM cells from different developmental stages' Lu, DY, Du M and Shen S* (1988) 'Construction of chimeric rabbits by blastocyst injection of ICM cells from different developmental stages'. Acta Zoologica Sinica, 34 :382-3 [Details]

Conference Publications

	Year	Publication
	(2017)	*International Society for Stem Cell Research* 6. Avazzadeh S, McDonagh K ,Quinlan L. Dockery P, Li M, McInerney V, Krawczyk J , O’Brien T, Gallagher L, Shen S (2017) Role of NRXN1 in neurodevelopmental disease: From stem cell to clinical phenotypes International Society for Stem Cell Research [Details]

Abstract

	Year	Publication
	(2013)	Establishing in Vitro Models of Autism Spectrum Disorders Using Induced Pluripotent Stem Cells. ISSCR Conference 2013, Boston. McDonagh K, Sotthibundhu A, Thompson K, McDermott E, Dockery P., Schwartz PH, Brick DJ, O’Brien T, Barry F, Shen S* (2013) Establishing in Vitro Models of Autism Spectrum Disorders Using Induced Pluripotent Stem Cells. ISSCR Conference 2013, Boston. Abstract [Details]
	(2013)	Autophagy mechanism in reprogramming and induced pluripotent stem cells. ISSCR Conference 2013, Boston. Sotthibundhu A, McDonagh K, Klawiter A, Thompson K, Dockery P., Devine M, Kunath T, O’Brien T, Barry F, Shen S* (2013) Autophagy mechanism in reprogramming and induced pluripotent stem cells. ISSCR Conference 2013, Boston. Abstract [Details]
	(2013)	Assessing The Therapeutic Potential Of Induced Pluripotent Stem Cells In In Vitro Models Of Acute Lung Injury. American Thoracic Society International Conference. 2013, Philadelphia. O'Toole D, Horie S, McDonagh K, Masterson CH, Shen S, Laffey JG. (2013) Assessing The Therapeutic Potential Of Induced Pluripotent Stem Cells In In Vitro Models Of Acute Lung Injury. American Thoracic Society International Conference. 2013, Philadelphia. Abstract [Details]
	(2012)	Stem cells and neural development. 2012. 7th Annual Neuroscience Ireland meeting, RCSI, Dublin. Shen S* (2012) Stem cells and neural development. 2012. 7th Annual Neuroscience Ireland meeting, RCSI, Dublin. Abstract [Details]
	(2012)	“A novel gene ULK4 is deleted in schizophrenia and crucial for neurite elongation and branching”. International Symposium on Molecular Cognition and Translational Research of Neuropsychiatric Research. 2012, Shanghai. Shen S* (2012) “A novel gene ULK4 is deleted in schizophrenia and crucial for neurite elongation and branching”. International Symposium on Molecular Cognition and Translational Research of Neuropsychiatric Research. 2012, Shanghai. Abstract [Details]
	(2011)	Creating Mouse Models of Behavioural and Psychiatric Disorders, Sheffield Institute for Translational Neuroscience, Sheffield University. Shen S. (2011) Creating Mouse Models of Behavioural and Psychiatric Disorders, Sheffield Institute for Translational Neuroscience, Sheffield University*. Abstract [Details]
	(2011)	Role of PACAP signaling in the adult neurogenesis Winter Neuropeptide Conference, 2011, Liverpool. Shen S* (2011) Role of PACAP signaling in the adult neurogenesis Winter Neuropeptide Conference, 2011, Liverpool. Abstract [Details]
	(2010)	Expression of Truncated DISC1 Associates with Schizophrenia‐Related Neural and Behavioral Phenotypes in Mice. DISC1 2010, Edinburgh. Shen S* (2010) Expression of Truncated DISC1 Associates with Schizophrenia‐Related Neural and Behavioral Phenotypes in Mice. DISC1 2010, Edinburgh. Abstract [Details]
	(2009)	Roles of PACAP signalling in mouse neurogenesis 19th Neuropharmacology Conference - NEUROPEPTIDES. Chicago. Shen S* (2009) Roles of PACAP signalling in mouse neurogenesis 19th Neuropharmacology Conference - NEUROPEPTIDES. Chicago. Abstract [Details]
	(2009)	PAC1 & mouse neurogenesis. The 9th International Symposium on VIP, PACAP, and Related Peptides. Kagoshima. Shen S* (2009) PAC1 & mouse neurogenesis. The 9th International Symposium on VIP, PACAP, and Related Peptides. Kagoshima. Abstract [Details]
	(2009)	PAC1 & neurogenesis, 30th Winter Neuropeptide Conference, Colorado. Shen S* (2009) PAC1 & neurogenesis, 30th Winter Neuropeptide Conference, Colorado. Abstract [Details]
	(1999)	Expression of the human PACAP (PAC1) receptor and a reporter gene from a modified P1 artificial chromosome in transgenic mice. Society for Neuroscience Abstracts 25: 1970. Shen S, Sheward WJ and Harmar AJ. (1999) Expression of the human PACAP (PAC1) receptor and a reporter gene from a modified P1 artificial chromosome in transgenic mice. Society for Neuroscience Abstracts 25: 1970*. Abstract [Details]
	(1999)	Expression of the rat and human VPAC2 receptor in the suprachiasmatic nucleus: rostro-caudal distribution and co-localization with vasopressin and VIP mRNA. Society for Neuroscience Abstracts 25: 1370. Kalló I, Kalamatianos T, Shen S, Sheward WJ, Okamura H, Powell JF, Campbell IC, Piggins HD, Harmar AJ and Coen CW. (1999) Expression of the rat and human VPAC2 receptor in the suprachiasmatic nucleus: rostro-caudal distribution and co-localization with vasopressin and VIP mRNA. Society for Neuroscience Abstracts 25: 1370. Abstract [Details]
	(1999)	ransgenic approaches to the understanding of VIP and PACAP receptor function. Regulatory Peptides 83: 58. Shen S, Sheward WJ, Kallo I, Coen CW and Harmar AJ. (1999) ransgenic approaches to the understanding of VIP and PACAP receptor function. Regulatory Peptides 83: 58*. Abstract [Details]
	(1992)	Regulation and function of RARb in embryonic stem cells and mouse development. Mouse Genetics Conference, Cold Spring Harbor. Shen S, Kruijer W, van der Saag PT (1992) Regulation and function of RARb in embryonic stem cells and mouse development. Mouse Genetics Conference, Cold Spring Harbor*. Abstract [Details]
	(1988)	Generation of mice lacking a receptor for VIP and PACAP (the VPAC2 receptor). Society for Neuroscience Abstracts 24: 2049. West KM, Shen S, Sheward WJ, Mackay MEH, Kilanowski FM, Lutz EM, Dorin JR and Harmar AJ. (1988) Generation of mice lacking a receptor for VIP and PACAP (the VPAC2 receptor). Society for Neuroscience Abstracts 24: 2049. Abstract [Details]

Editorial

	Year	Publication
	(2017)	Clinical characterisation of neurexin1 deletions and their role in neurodevelopmental disorders. Fitzgerald, J,Al-Shehhi, M,Lynch, S,Shen, S,Gallagher, L (2017) Clinical characterisation of neurexin1 deletions and their role in neurodevelopmental disorders. Editorial [Details]

Invited papers

	Year	Publication
	(2011)	Animal and cellular modeling of neurodevelopmental disorders. 2011 Galway Neuroscience Research Day, Galway. Shen S* (2011) Animal and cellular modeling of neurodevelopmental disorders. 2011 Galway Neuroscience Research Day, Galway. Invited papers [Details]

Invited Seminars

	Year	Publication
	(2008)	“Neuropeptide Signalling, Stem Cells & Neurodevelopmental Disorders”. School of Biomedical Sciences, University of Liverpool, UK. Shen, S. (2008) “Neuropeptide Signalling, Stem Cells & Neurodevelopmental Disorders”. School of Biomedical Sciences, University of Liverpool, UK. Invited Seminars [Details]
	(2009)	“Genetic modelling of neurodevelopmental disorders”. Molecular Medicine Centre, University of Edinburgh, UK. Shen, S. (2009) “Genetic modelling of neurodevelopmental disorders”. Molecular Medicine Centre, University of Edinburgh, UK. Invited Seminars [Details]
	(2009)	“PAC1 & mouse neurogenesis”, 9th International Symposium on VIP, PACAP & Related Peptides, Kagoshima, Japan. Shen, S. (2009) “PAC1 & mouse neurogenesis”, 9th International Symposium on VIP, PACAP & Related Peptides, Kagoshima, Japan. Invited Seminars [Details]
	(2009)	“PAC1 & neurogenesis” 30th Winter Neuropeptide Conference, Colorado, USA. Shen, S. (2009) “PAC1 & neurogenesis” 30th Winter Neuropeptide Conference, Colorado, USA. Invited Seminars [Details]
	(2010)	“Stem Cells and Brain Development”, Strathclyde University, Glasgow. Shen, S. (2010) “Stem Cells and Brain Development”, Strathclyde University, Glasgow. Invited Seminars [Details]
	(2010)	“Genetic Modeling of Neurodevelopmental disorders”. FMMU, Tang Du Hospital, Xi’an. Shen, S. (2010) “Genetic Modeling of Neurodevelopmental disorders”. FMMU, Tang Du Hospital, Xi’an. Invited Seminars [Details]
	(2010)	“Genetic Modeling of Neurodevelopmental disorders”. FMMU, Institute of Neuroscience, Xi’an. Shen, S. (2010) “Genetic Modeling of Neurodevelopmental disorders”. FMMU, Institute of Neuroscience, Xi’an. Invited Seminars [Details]
	(2010)	“PAC1 & mouse neurogenesis”, 19th Neuropharmacology Conference – Neuropeptides, Chicago, USA. Shen, S. (2010) “PAC1 & mouse neurogenesis”, 19th Neuropharmacology Conference – Neuropeptides, Chicago, USA. Invited Seminars [Details]
	(2011)	“Neurological Diseases & Regenerative Medicine”, Hebei Normal University, China. Shen, S. (2011) “Neurological Diseases & Regenerative Medicine”, Hebei Normal University, China. Invited Seminars [Details]
	(2011)	“Neurological disorders & Regenerative Medicine”. Tangdu Hospital, China. Attended as VIP at Neurosurgery Hospital opening ceremony. Shen, S. (2011) “Neurological disorders & Regenerative Medicine”. Tangdu Hospital, China. Attended as VIP at Neurosurgery Hospital opening ceremony. Invited Seminars [Details]
	(2011)	“Neurological Diseases & Regenerative Medicine”, Life Science College, Zhejiang University. Shen, S. (2011) “Neurological Diseases & Regenerative Medicine”, Life Science College, Zhejiang University. Invited Seminars [Details]
	(2011)	“Stem Cell Therapies: State of the Art”, Science Foundation Ireland, Dublin. Shen, S. (2011) “Stem Cell Therapies: State of the Art”, Science Foundation Ireland, Dublin. Invited Seminars [Details]
	(2011)	“Creating Mouse Models of Behavioural and Psychiatric Disorders”, Sheffield Institute for Translational Neuroscience, Sheffield University, UK. Shen, S. (2011) “Creating Mouse Models of Behavioural and Psychiatric Disorders”, Sheffield Institute for Translational Neuroscience, Sheffield University, UK. Invited Seminars [Details]
	(2011)	“Stem cells and genetic modelling of neurological disorders”, CLSS-UK, Edinburgh. Shen, S. (2011) “Stem cells and genetic modelling of neurological disorders”, CLSS-UK, Edinburgh. Invited Seminars [Details]
	(2011)	“Plans for the Development of a Basic Research Programme in Stem Cell Biology at REMEDI”, REMEDI/NCBES, NUI Galway. Shen, S (2011) “Plans for the Development of a Basic Research Programme in Stem Cell Biology at REMEDI”, REMEDI/NCBES, NUI Galway. Invited Seminars [Details]
	(2011)	“Role of PACAP signaling in adult neurogenesis” Winter Neuropeptide Conference, Liverpool. Shen, S. (2011) “Role of PACAP signaling in adult neurogenesis” Winter Neuropeptide Conference, Liverpool. Invited Seminars [Details]
	(2011)	“Animal and cellular modeling of neurodevelopmental disorders”. Galway Neuroscience Research Day. Shen, S. (2011) “Animal and cellular modeling of neurodevelopmental disorders”. Galway Neuroscience Research Day. Invited Seminars [Details]
	(2012)	Attending International Autism Conference at NUI Galway organised by Geraldine Leader. Shen, S. (2012) Attending International Autism Conference at NUI Galway organised by Geraldine Leader. Invited Seminars [Details]
	(2012)	“Stem cells and neural development”. 7th Annual Neuroscience Ireland meeting, Royal College of Surgeons in Ireland, Dublin, Ireland. Shen, S. (2012) “Stem cells and neural development”. 7th Annual Neuroscience Ireland meeting, Royal College of Surgeons in Ireland, Dublin, Ireland. Invited Seminars [Details]
	(2012)	“Neurological Diseases & Regenerative Medicine”. Life Science College, Zhejiang University. Shen, S. (2012) “Neurological Diseases & Regenerative Medicine”. Life Science College, Zhejiang University. Invited Seminars [Details]
	(2012)	“A novel gene ULK4 is deleted in schizophrenia and crucial for neurite elongation and branching”. International Symposium on Molecular Cognition and Translational Research of Neuropsychiatric Research. Shanghai. Shen, S. (2012) “A novel gene ULK4 is deleted in schizophrenia and crucial for neurite elongation and branching”. International Symposium on Molecular Cognition and Translational Research of Neuropsychiatric Research. Shanghai. Invited Seminars [Details]
	(2012)	“iPS cell modeling of neurological diseases”. FMMU, Xi’an, China. Shen, S. (2012) “iPS cell modeling of neurological diseases”. FMMU, Xi’an, China. Invited Seminars [Details]
	(2012)	“iPS cell modeling of neurological diseases”. Xinhua Hospital, Shanghai Jiao Tong University. Shen, S. (2012) “iPS cell modeling of neurological diseases”. Xinhua Hospital, Shanghai Jiao Tong University. Invited Seminars [Details]
	(2012)	“iPS cell modeling of neurological diseases”. Bio-X Institute, Shanghai Jiao Tong University. Shen, S. (2012) “iPS cell modeling of neurological diseases”. Bio-X Institute, Shanghai Jiao Tong University. Invited Seminars [Details]
	(2013)	“Induced Pluripotent Stem cell models for autism and Fragile X syndrome”, Anti-aging and Regenerative Medicine, Shenzhen. Shen, S. (2013) “Induced Pluripotent Stem cell models for autism and Fragile X syndrome”, Anti-aging and Regenerative Medicine, Shenzhen. Invited Seminars [Details]
	(2013)	“Animal and cellular modeling of neurodevelopmental disorders”, Brussels Meeting for H2020. Shen, S. (2013) “Animal and cellular modeling of neurodevelopmental disorders”, Brussels Meeting for H2020. Invited Seminars [Details]
	(2013)	“Involvement Of A Novel Kinase ULK4 In Neurodevelopmental Disorders In Mice And Humans”, The 1st Annual Molecular Psychiatry Meeting in San Francisco. Shen, S. (2013) “Involvement Of A Novel Kinase ULK4 In Neurodevelopmental Disorders In Mice And Humans”, The 1st Annual Molecular Psychiatry Meeting in San Francisco. Invited Seminars [Details]
	(2013)	09/13 “Animal /Stem Cell Modeling and Regenerative Medicine”, Healthy Workshop at Shenzhen University, SFI ISCA programme. Shen, S. (2013) 09/13 “Animal /Stem Cell Modeling and Regenerative Medicine”, Healthy Workshop at Shenzhen University, SFI ISCA programme. Invited Seminars [Details]
	(2013)	6 Invited Lectures at Shanghai Jiaotong University in a Summer course of “Brain Facts. Shen, S. (2013) 6 Invited Lectures at Shanghai Jiaotong University in a Summer course of “Brain Facts. Invited Seminars [Details]
	(2013)	“Induced Pluripotent Stem (iPS) Cell Research for Autism at NUIG”, 2nd International Conference on Autism Spectrum Disorders, NUI Galway. Shen, S. (2013) “Induced Pluripotent Stem (iPS) Cell Research for Autism at NUIG”, 2nd International Conference on Autism Spectrum Disorders, NUI Galway. Invited Seminars [Details]
	(2013)	“Modeling Neurodevelopmental Disorders in Transgenic Mice and Human Induced Pluripotent Stem Cells”, CLASS seminar, UCD. Shen, S. (2013) “Modeling Neurodevelopmental Disorders in Transgenic Mice and Human Induced Pluripotent Stem Cells”, CLASS seminar, UCD. Invited Seminars [Details]
	(2014)	“Modeling Neurodevelopmental Disorders in Mice and In Human Induced Pluripotent Stem Cells”, Glasgow Caledonian University. Shen, S (2014) “Modeling Neurodevelopmental Disorders in Mice and In Human Induced Pluripotent Stem Cells”, Glasgow Caledonian University. Invited Seminars [Details]

Reviews

	Year	Publication
	(2016)	In vitro and ex vivo models of multiple sclerosis. Madill M;Fitzgerald D;O'Connell KE;Dev KK;Shen S;FitzGerald U; (2016) In vitro and ex vivo models of multiple sclerosis. Reviews [DOI] [Details]
	(2012)	Progress on stem cell research towards the treatment of Parkinson's disease. Gibson, SAJ,Gao, GD,McDonagh, K,Shen, SB (2012) Progress on stem cell research towards the treatment of Parkinson's disease. Reviews [DOI] [Details]