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Medicine

Dr Sanjeev Gupta

B.Sc.,M.Sc.,Ph.D

Contact Details

Senior Lecturer
Pathology
School of Medicine
NUI Galway
T: 544488
E: sanjeev.gupta@nuigalway.ie
 
researcher
 

Biography

Dr. Gupta graduated with a B.Sc from the Delhi University, in 1994.  He completed M.Sc in Biochemistry from the Hamdard University in 1996. Dr. Gupta was awarded prestigious CSIR-UGC fellowship for his PhD and was conferred by the Jawaharlal Nehru University, New Delhi, India with a PhD in 2002. Outstanding research achievements during his PhD have been recognized in terms of nomination for Indian National Science Academy, young scientist award.


Dr. Gupta did his postdoctoral training with Prof. Emad Alnemri, a world leader in the field of apoptosis. After a short stint as an assistant professor, at Indian Institute of Technology-Madras, He joined NUI Galway as a Senior Researcher in September 2007. He was appointed as a Lecturer in Pathology at School of Medicine, NUI Galway in December 2010.


Research Interests

Research Focus 1: Unfolded protein response in cancer: regulation by microRNAs

The stressful conditions in the tumour microenvironment including low oxygen supply, nutrient deprivation and pH changes activate a range of cellular stress-response pathways. Tumour hypoxia is a common microenvironmental factor that adversely influences tumour phenotype and treatment response. Cellular adaptation to hypoxia occurs through multiple mechanisms, including activation of the unfolded protein response (UPR). UPR attempts to restore ER homeostasis by increasing ER bio-genesis, decreasing the influx of new proteins into the ER, promoting the transport of damaged proteins from the ER to the cytosol for degradation, and upregulating protein folding chaperones. Although the unfolded protein response is primarily a pro-survival response, in the event of prolonged or severe ER stress that is not resolved, the unfolded protein response switches to initiation of apoptosis. The molecular mechanisms involved in the transition of the UPR from a protective to an apoptotic phase are unclear.   

MicroRNAs (miRNAs) have been shown to be critically involved in control of cell survival and cell death decisions. The main function of miRNAs is to direct posttranscriptional regulation of gene expression, typically by binding to 3’ UTR of cognate mRNAs and inhibiting their translation and/or stability. Global downregulation of miRNAs is a common feature of human tumours. Loss of miRNA biogenesis has been shown to enhance cancer progression. Further several components of miRNA biogenesis machinery (XPO5, DICER and TRBP) have been shown to act as haploinsufficient tumour suppressors. How the dysregulation of miRNA biogenesis promotes tumour development is not clearly understood. The main focus of research in my group is to evaluate the role of microRNAs in determining cell fate during conditions of ER stress.  We use a combination of molecular cell biology, transcriptomics, proteomics and miRNA expression profiling to address specific questions such as:
(i) What is the role of miRNAs in ER stress-induced apoptosis?
(ii) Does impaired miRNA biogenesis contribute to cancer progression by inhibiting ER stress-induced apoptosis?

Research Focus 2: Role of IRE1-XBP1 axis in endocrine resistance in ER-positive breast cancer
Invasive breast cancer (IBC) is a heterogeneous disease with varied molecular features, behaviour, and response to therapy. Over the past decade, transcriptome-wide studies of patients with IBC have lead to the identification of clinically relevant subtypes: luminal A, luminal B, HER2-overexpressing, basal-like and normal breast tissue-like. The Cancer Genome Atlas (TCGA) consortium recently reported that most dominant feature of Luminal/ER-positive breast cancers is increased mRNA and protein levels of ESR1, GATA3, FOXA1, XBP1 and MYB. Recent studies indicate a crucial role for the IRE1/XBP1 pathway in several aspects of ER-positive breast cancer (Figure1).  XBP1 is transcriptionally induced during estrogen stimulation and XBP1s protein expression is upregulated following estradiol (E2) treatment of ER-positive human breast cancer cell lines. XBP1 physically interacts with ER and potentiate ER-dependent transcriptional activity in a ligand-independent manner. Ectopic expression of XBP1s in ER-positive breast cancer cells can lead to estrogen-independent growth and reduced sensitivity to anti-estrogens. Expression of XBP1s is significantly associated with clinical outcome of endocrine-treated breast cancer. We are taking a multidisciplinary approach to elucidate the role of the IRE1-XBP1 in regulation of estrogen signalling underpinning anti-estrogen resistance in breast cancer. The central questions are:

(i)  How estrogen signalling intersects with the UPRosome to regulate its activation?
(ii) What is the transcriptional network of XBP1s in the context of estrogen signalling?
(iii) What is the therapeutic and prognostic value of IRE1-XBP1 axis in ER-positive breast cancer?

Research Projects

  Project Start Date End Date
IRC POSTGRADUATE SCHOLARSHIP 2016 DAVID BARUA - Prognostic value of XBP1-gene signature in ER-positive breast cancer 01-OCT-16 30-SEP-20
Regulation of NCOA3 expression by UPR and its role in endocrine resistance 01-FEB-12 31-OCT-15
EXPRESSION OF DICER IN BREAST CANCER AND ITS ASSOCIATION WITH MOLECULAR SUBTYPES BIOMARKER EXPRESSION AND PATIENT OUTCOMES SGS2011010 16 SANJEEV GUPTA 01-JAN-12 31-DEC-15
GENERAL ACCOUNT SANJEEV GUPTA 01-DEC-11 31-DEC-20
MILLENNIUM FUND 2010 IDENTIFICATION OF NOVEL PROGNOSTIC AND PREDICTIVE MARKERS FOR BREAST CANCER SANJEEV GUPTA 01-MAR-11 28-FEB-13
Role of miR-17-92 cluster in regulating fate of cardiomyocytes during ischemia 01-FEB-11 15-APR-15
HRB HRA HSR 2010 24 SANJEEV GUPTA 01-FEB-11 30-APR-15

Peer Reviewed Journals

  Year Publication
(2020) 'XBP1 increases transactivation of somatic mutants of ESR1 and loss of XBP1 reverses endocrine resistance conferred by gain-of-function Y537S ESR1 mutation'
Barua, D,Abbasi, B,Gupta, A,Gupta, S (2020) 'XBP1 increases transactivation of somatic mutants of ESR1 and loss of XBP1 reverses endocrine resistance conferred by gain-of-function Y537S ESR1 mutation'. Heliyon, 6 [DOI] [Details]
(2006) 'cIAP2 is a ubiquitin protein ligase for BCL10 and is dysregulated in mucosa-associated lymphoid tissue lymphomas'
Hu S;Du MQ;Park SM;Alcivar A;Qu L;Gupta S;Tang J;Baens M;Ye H;Lee TH;Marynen P;Riley JL;Yang X; (2006) 'cIAP2 is a ubiquitin protein ligase for BCL10 and is dysregulated in mucosa-associated lymphoid tissue lymphomas'. Journal Of Clinical Investigation, 116 (1) [DOI] [Details]
(2005) 'Role of p73 in regulating human caspase-1 gene transcription induced by interferon-{gamma} and cisplatin'
Jain N;Gupta S;Sudhakar Ch;Radha V;Swarup G; (2005) 'Role of p73 in regulating human caspase-1 gene transcription induced by interferon-{gamma} and cisplatin'. Journal Of Biological Chemistry, 280 (44) [DOI] [Details]
(2005) 'Caspase-1 activator Ipaf is a p53-inducible gene involved in apoptosis'
Sadasivam S;Gupta S;Radha V;Batta K;Kundu TK;Swarup G; (2005) 'Caspase-1 activator Ipaf is a p53-inducible gene involved in apoptosis'. Oncogene, 24 (4) [DOI] [Details]
(2004) 'The C-terminal tail of presenilin regulates Omi/HtrA2 protease activity'
Gupta S;Singh R;Datta P;Zhang Z;Orr C;Lu Z;Dubois G;Zervos AS;Meisler MH;Srinivasula SM;Fernandes-Alnemri T;Alnemri ES; (2004) 'The C-terminal tail of presenilin regulates Omi/HtrA2 protease activity'. Journal Of Biological Chemistry, 279 (44) [DOI] [Details]
(2004) 'Regulation of HAX-1 anti-apoptotic protein by Omi/HtrA2 protease during cell death'
Cilenti L;Soundarapandian MM;Kyriazis GA;Stratico V;Singh S;Gupta S;Bonventre JV;Alnemri ES;Zervos AS; (2004) 'Regulation of HAX-1 anti-apoptotic protein by Omi/HtrA2 protease during cell death'. Journal Of Biological Chemistry, 279 (48) [DOI] [Details]
(2003) 'Inhibitor of apoptosis proteins are substrates for the mitochondrial serine protease Omi/HtrA2'
Srinivasula SM;Gupta S;Datta P;Zhang Z;Hegde R;Cheong N;Fernandes-Alnemri T;Alnemri ES; (2003) 'Inhibitor of apoptosis proteins are substrates for the mitochondrial serine protease Omi/HtrA2'. Journal Of Biological Chemistry, 278 (34) [DOI] [Details]
(2001) 'A nuclear protein tyrosine phosphatase induces shortening of G1 phase and increase in c-Myc protein level'
Ganapati U;Gupta S;Radha V;Sudhakar C;Manogaran PS;Swarup G; (2001) 'A nuclear protein tyrosine phosphatase induces shortening of G1 phase and increase in c-Myc protein level'. Experimental Cell Research, 265 (1) [DOI] [Details]
(2020) 'Differential expression, function and prognostic value of miR-17-92 cluster in ER-positive and triple-negative breast cancer'
Hossain MM;Sultana A;Barua D;Islam MN;Gupta A;Gupta S; (2020) 'Differential expression, function and prognostic value of miR-17-92 cluster in ER-positive and triple-negative breast cancer'. Cancer Treatment And Research Communications, 25 [DOI] [Details]
(2020) 'XBP1 increases transactivation of somatic mutants of ESR1 and loss of XBP1 reverses endocrine resistance conferred by gain-of-function Y537S ESR1 mutation'
Barua D;Abbasi B;Gupta A;Gupta S; (2020) 'XBP1 increases transactivation of somatic mutants of ESR1 and loss of XBP1 reverses endocrine resistance conferred by gain-of-function Y537S ESR1 mutation'. Heliyon, 6 (10) [DOI] [Details]
(2020) 'Targeting the IRE1-XBP1 axis to overcome endocrine resistance in breast cancer: Opportunities and challenges'
Barua D;Gupta A;Gupta S; (2020) 'Targeting the IRE1-XBP1 axis to overcome endocrine resistance in breast cancer: Opportunities and challenges'. Cancer Letters, 486 [DOI] [Details]
(2019) 'Management of Chemotherapy Induced Neutropenia – an Unmet Clinical Need'
Ananya Gupta, Benazir Abbasi, Sanjeev Gupta (2019) 'Management of Chemotherapy Induced Neutropenia – an Unmet Clinical Need'. American Journal Of Clinical Oncology, [DOI] [Details]
(2018) 'Hyperactivation of nuclear receptor coactivators induces PERK-dependent cell death'
Hossain MM;Barua D;Arabkari V;Islam N;Gupta A;Gupta S; (2018) 'Hyperactivation of nuclear receptor coactivators induces PERK-dependent cell death'. Oncotarget, 9 (14) [DOI] [Details]
(2016) 'NCOA3 coactivator is a transcriptional target of XBP1 and regulates PERK-eIF2¿-ATF4 signalling in breast cancer'
Gupta A;Hossain MM;Miller N;Kerin M;Callagy G;Gupta S; (2016) 'NCOA3 coactivator is a transcriptional target of XBP1 and regulates PERK-eIF2¿-ATF4 signalling in breast cancer'. Oncogene, [DOI] [Details]
(2015) 'BCL-2 modulates the unfolded protein response by enhancing splicing of X-box binding protein-1'
Chonghaile TN, Gupta S;John M;Szegezdi E;Logue SE;Samali A (2015) 'BCL-2 modulates the unfolded protein response by enhancing splicing of X-box binding protein-1'. Biochem. Biophys. Res. Commun, 466 (1):40-45 [DOI] [Details]
(2015) 'PERK regulated miR-424(322)-503 cluster fine-tunes activation of IRE1 and ATF6 during Unfolded Protein Response'
Gupta, A,Hossain, MM,Read, DE,Hetz, C,Samali, A,Gupta, S (2015) 'PERK regulated miR-424(322)-503 cluster fine-tunes activation of IRE1 and ATF6 during Unfolded Protein Response'. Scientific Reports, 5 [DOI] [Details]
(2015) 'A close connection between the PERK and IRE arms of the UPR and the transcriptional regulation of autophagy'
Deegan, S,Koryga, I,Glynn, SA,Gupta, S,Gorman, AM,Samali, A (2015) 'A close connection between the PERK and IRE arms of the UPR and the transcriptional regulation of autophagy'. Biochemical And Biophysical Research Communications, 456 :305-311 [DOI] [Details]
(2014) 'miRNA signature of unfolded protein response in H9c2 rat cardiomyoblasts'
Read, DE,Gupta, A,Ladilov, Y,Samali, A,Gupta, S (2014) 'miRNA signature of unfolded protein response in H9c2 rat cardiomyoblasts'. Cell And Bioscience, 4 [DOI] [ARAN Link] [Details]
(2014) 'ER stress responses in the absence of apoptosome: A comparative study in CASP9 proficient vs deficient mouse embryonic fibroblasts'
Deegan, S,Saveljeva, S,Gupta, S,MacDonald, DC,Samali, A (2014) 'ER stress responses in the absence of apoptosome: A comparative study in CASP9 proficient vs deficient mouse embryonic fibroblasts'. Biochemical And Biophysical Research Communications, 451 :367-373 [DOI] [Details]
(2014) 'Deficiency in the mitochondrial apoptotic pathway reveals the toxic potential of autophagy under ER stress conditions'
Deegan S, Saveljeva S;Logue SE;Pakos-Zebrucka K;Gupta S;Vandenabeele P;Bertrand MJ;Samali A (2014) 'Deficiency in the mitochondrial apoptotic pathway reveals the toxic potential of autophagy under ER stress conditions'. Autophagy, 10 (11):1921-1936 [DOI] [Details]
(2013) 'Pro-apoptotic signaling induced by photo-oxidative ER stress is amplified by Noxa, not Bim'
Verfaillie T, van Vliet A, Garg AD, Dewaele M, Rubio N, Gupta S, de Witte P, Samali A, Agostinis P (2013) 'Pro-apoptotic signaling induced by photo-oxidative ER stress is amplified by Noxa, not Bim'. Biochem, 438 (3):500-506 [DOI] [Details]
(2013) 'Disruption of microRNA biogenesis confers resistance to ER stress-induced cell death upstream of the mitochondrion'
Cawley K;Logue SE;Gorman AM;Zeng Q;Patterson J;Gupta S;Samali A; (2013) 'Disruption of microRNA biogenesis confers resistance to ER stress-induced cell death upstream of the mitochondrion'. Plos One, 8 (8) [DOI] [Details]
(2013) 'The eIF2 alpha kinases: their structures and functions'
Donnelly, N,Gorman, AM,Gupta, S,Samali, A (2013) 'The eIF2 alpha kinases: their structures and functions'. Cell Mol Life Sci, 70 :3493-3511 [DOI] [Details]
(2012) 'Bisphenol A-mediated suppression of LPL gene expression inhibits triglyceride accumulation during adipogenic differentiation of human adult stem cells'
Linehan C, Gupta S, Samali A, O'Connor L (2012) 'Bisphenol A-mediated suppression of LPL gene expression inhibits triglyceride accumulation during adipogenic differentiation of human adult stem cells'. Plos One, 7 (5) [DOI] [Details]
(2012) 'Impairment of endoplasmic reticulum in liver as an early consequence of the systemic inflammatory response in rats'
Nurnberger, S,Miller, I,Duvigneau, JC,Kavanagh, ET,Gupta, S,Hartl, RT,Hori, O,Gesslbauer, B,Samali, A,Kungl, A,Redl, H,Kozlov, AV (2012) 'Impairment of endoplasmic reticulum in liver as an early consequence of the systemic inflammatory response in rats'. American Journal Of Physiology-Gastrointestinal And Liver Physiology, 303 :1373-1383 [DOI] [Details]
(2012) 'NOXA contributes to the sensitivity of PERK-deficient cells to ER stress'
Gupta S, Giricz Z, Natoni A, Donnelly N, Deegan S, Szegezdi E, Samali A (2012) 'NOXA contributes to the sensitivity of PERK-deficient cells to ER stress'. Febs Letters, 586 (22):4023-4030 [DOI] [Details]
(2012) 'PERK is required at the ER-mitochondrial contact sites to convey apoptosis after ROS-based ER stress'
Verfaillie, T,Rubio, N,Garg, AD,Bultynck, G,Rizzuto, R,Decuypere, JP,Piette, J,Linehan, C,Gupta, S,Samali, A,Agostinis, P (2012) 'PERK is required at the ER-mitochondrial contact sites to convey apoptosis after ROS-based ER stress'. Cell Death And Differentiation, 19 :1880-1891 [DOI] [Details]
(2012) 'Perk-dependent repression of miR-106b-25 cluster is required for ER stress-induced apoptosis'
Gupta, S,Read, DE,Deepti, A,Cawley, K,Gupta, A,Oommen, D,Verfaillie, T,Matus, S,Smith, MA,Mott, JL,Agostinis, P,Hetz, C,Samali, A (2012) 'Perk-dependent repression of miR-106b-25 cluster is required for ER stress-induced apoptosis'. Cell Death & Disease, 3 [DOI] [Details]
(2011) 'Unfolded proteins and endoplasmic reticulum stress in neurodegenerative disorders'
Doyle KM, Kennedy D, Gorman AM, Gupta S, Healy SJ, Samali A (2011) 'Unfolded proteins and endoplasmic reticulum stress in neurodegenerative disorders'. Journal Of Cellular And Molecular Medicine, 15 (10):2025-2039 [DOI] [Details]
(2010) 'Mechanisms of ER Stress-Mediated Mitochondrial Membrane Permeabilization'
Gupta S;Cuffe L;Szegezdi E;Logue SE;Neary C;Healy S;Samali A; (2010) 'Mechanisms of ER Stress-Mediated Mitochondrial Membrane Permeabilization'. International Journal Of Cell Biology, 2010 [DOI] [Details]
(2010) 'HSP72 protects cells from ER stress-induced apoptosis via enhancement of IRE1alpha-XBP1 signaling through a physical interaction'
Gupta S, Deepti A, Deegan S, Lisbona F, Hetz C, Samali A (2010) 'HSP72 protects cells from ER stress-induced apoptosis via enhancement of IRE1alpha-XBP1 signaling through a physical interaction'. Plos Biology, 8 (7) [DOI] [Details]
(2010) 'Methods for monitoring endoplasmic reticulum stress and the unfolded protein response'
Samali A, Fitzgerald U, Deegan S, Gupta S (2010) 'Methods for monitoring endoplasmic reticulum stress and the unfolded protein response'. International Journal Of Cell Biology, 2010 [DOI] [Details]
(2009) 'Bcl-2 family on guard at the ER'
Szegezdi E, Macdonald DC, Ní Chonghaile T, Gupta S, Samali A. (2009) 'Bcl-2 family on guard at the ER'. Am J Physiol Cell Physiol (Epub 2009 Mar 11. Review.PMID: 19279228 [PubMed - indexed for MEDLINE]), 296 (5):941-953 [Details]
(2009) 'Targeting the endoplasmic reticulum-stress response as an anticancer strategy'
Healy, SJM,Gorman, AM,Mousavi-Shafaei, P,Gupta, S,Samali, A (2009) 'Targeting the endoplasmic reticulum-stress response as an anticancer strategy'. European Journal Of Pharmacology, 625 :234-246 [DOI] [Details]
(2009) 'The mitochondrial death pathway: a promising therapeutic target in diseases'
Gupta S;Kass GE;Szegezdi E;Joseph B; (2009) 'The mitochondrial death pathway: a promising therapeutic target in diseases'. Journal Of Cellular And Molecular Medicine, 13 (6) [DOI] [Details]
(2011) 'ASSAYS FOR DETECTING THE UNFOLDED PROTEIN RESPONSE'
Cawley, K;Deegan, S;Samali, A;Gupta, S (2011) 'ASSAYS FOR DETECTING THE UNFOLDED PROTEIN RESPONSE'. Methods In Enzymology: Unfolded Protein Response And Cellular Stress, Vol 490, Pt B, 490 :31-51 [DOI] [Details]
(2012) 'Oestrogen-dependent regulation of miRNA biogenesis: many ways to skin the cat'
Gupta, A;Caffrey, E;Callagy, G;Gupta, S (2012) 'Oestrogen-dependent regulation of miRNA biogenesis: many ways to skin the cat'. Biochemical Society Transactions, 40 :752-758 [DOI] [Details]
(2013) 'Prognostic Significance of Deregulated Dicer Expression in Breast Cancer'
Caffrey, E;Ingoldsby, H;Wall, D;Webber, M;Dinneen, K;Murillo, LS;Inderhaug, C;Newell, J;Gupta, S;Callagy, G (2013) 'Prognostic Significance of Deregulated Dicer Expression in Breast Cancer'. Plos One, 8 [DOI] [Details]
(2015) 'Assays for Induction of the Unfolded Protein Response and Selective Activation of the Three Major Pathways'
Gupta, A;Read, DE;Gupta, S (2015) 'Assays for Induction of the Unfolded Protein Response and Selective Activation of the Three Major Pathways'. Methods in Molecular Biology, 1292 :19-38 [DOI] [Details]
(2017) 'HSPB1 facilitates ERK-mediated phosphorylation and degradation of BIM to attenuate endoplasmic reticulum stress-induced apoptosis'
Kennedy, D,Mnich, K,Oommen, D,Chakravarthy, R,Almeida-Souza, L,Krols, M,Saveljeva, S,Doyle, K,Gupta, S,Timmerman, V,Janssens, S,Gorman, AM,Samali, A (2017) 'HSPB1 facilitates ERK-mediated phosphorylation and degradation of BIM to attenuate endoplasmic reticulum stress-induced apoptosis'. Cell Death & Disease, 8 [DOI] [Details]
(2018) 'Investigation of Anemia and Pie Dielectric Properties of Human Blood at Microwave Frequencies'
Santorelli, A;Abbasi, B;Lyons, M;Hayat, A;Gupta, S;O'Halloran, M;Gupta, A (2018) 'Investigation of Anemia and Pie Dielectric Properties of Human Blood at Microwave Frequencies'. Ieee Access, 6 :56885-56892 [DOI] [Details]
(2012) 'Estrogen-dependent regulation of miRNA biogenesis: many ways to skin the cat'
Ananya Gupta, Emer Caffrey, Grace Callagy, Sanjeev Gupta. (2012) 'Estrogen-dependent regulation of miRNA biogenesis: many ways to skin the cat'. Biochemical Society Transactions, [Details]
(2003) 'Loss of Omi/HtrA2 protease activity causes neuromuscular disorder in mnd2 mutant mice'
Jones JM, Datta P, Srinivasula SM, Ji W, Gupta S, Zhang Z, Davies E, Hajnóczky G, Saunders TL, Van Keuren ML, Fernandes-Alnemri T, Meisler MH, Alnemri ES. (2003) 'Loss of Omi/HtrA2 protease activity causes neuromuscular disorder in mnd2 mutant mice'. Nature, [DOI] [Details]
(2002) 'A nuclear protein tyrosine phosphatase activates p53 and induces caspase-1-dependent apoptosis'
Gupta S, Radha V, Sudhakar Ch, Swarup G. (2002) 'A nuclear protein tyrosine phosphatase activates p53 and induces caspase-1-dependent apoptosis'. Febs Letters, [Details]
(2001) 'Direct transcriptional activation of human caspase-1 by tumor suppressor p53'
Gupta S, Radha V, Furukawa Y, Swarup G. (2001) 'Direct transcriptional activation of human caspase-1 by tumor suppressor p53'. Journal Of Biological Chemistry, [DOI] [Details]

Book Chapters

  Year Publication
(2015) 'Assays for Induction of the Unfolded Protein Response and Selective Activation of the Three Major Pathways'
Gupta, A,Read, DE,Gupta, S,Oslowski, CM (2015) 'Assays for Induction of the Unfolded Protein Response and Selective Activation of the Three Major Pathways' In: Moethod and Protocols. :19-38 UK: Elsevier Inc. [DOI] [Details]
(2011) 'ASSAYS FOR DETECTING THE UNFOLDED PROTEIN RESPONSE'
Cawley, K,Deegan, S,Samali, A,Gupta, S (2011) 'ASSAYS FOR DETECTING THE UNFOLDED PROTEIN RESPONSE' In: Methods in enzymology. :31-51 UK: Elsevier Inc. [DOI] [Details]

Conference Publications

  Year Publication
(2017) San Antonio Breast Cancer Symposium; 2017 Dec 5-9
MM Hossain, V Arabkari, D Barua, A Gupta, MN Islam and S Gupta (2017) miR-17-92 cluster, an oncogenic microRNA cluster acts as a context dependent tumour suppressor in breast cancer. Cancer Res 2018;78(4 Suppl):Abstract nr P5-07-14 San Antonio Breast Cancer Symposium; 2017 Dec 5-9 [Details]
(2013) 7th Joint Meeting of the British-Division of the Pathology Society
Caffrey, E,Wall, D,Webber, M,Dinneen, K,Ingoldsby, H,Murillo, L,Inderhaug, CR,Newell, J,Gupta, S,Callagy, G (2013) Prognostic Significance of Deregulated Dicer Expression in Breast Cancer. Journal of Pathology. Volume: 231 7th Joint Meeting of the British-Division of the Pathology Society , pp.32-32 [Details]
(2013) 7th Joint Meeting of the British-Division of the Pathology Society
Ingoldsby, H,Caffrey, E,Webber, M,Gupta, S,Callagy, G (2013) Characterisation of Expression of MicroRNAs miR-4726 and miR-4728 in HER2-expressing Breast Cancer. Journal of Pathology.Vol 231 7th Joint Meeting of the British-Division of the Pathology Society , pp.32-32 [Details]
(2010) 8th World Congress on Trauma, Shock, Inflammation and Sepsis
Sanjeev Gupta. (2010) Pathologic impact of ER stress: regulation by Hsp72. Inflammation Research Volume: 59 Pages: S159-S160 8th World Congress on Trauma, Shock, Inflammation and Sepsis [Details]
(2010) 8th World Congress on Trauma, Shock, Inflammation and Sepsis
Nuernberger, S,Gupta, S,Kavanagh, ET,Duvigneau, JC,Miller, I,Hori, O,Samali, A,Redl, H,Kozlov, AV (2010) Ultrastructural changes and underlying molecular mechanisms in rat livers induced by endotoxic shock. Nuernberger, S.; Gupta, S.; Kavanagh, E. T.; et al. Shock Volume: 33 Pages: 79 8th World Congress on Trauma, Shock, Inflammation and Sepsis , pp.79-79 [Details]
(2010) Annual Conference of the Society-for-Glycobiology
Gupta, S; Gerlach, J; Miura, Y; Yamazaki, T; Nakahara, T; Asada, H; Samali, A; Joshi, L. (2010) High Throughput Glycanmap (R) Analysis of Glycosylation during ER Stress and Apoptosis in a Colon Cancer Model.Glycobiology Volume: 20 Issue: 11 Pages: 1471 Annual Conference of the Society-for-Glycobiology [Details]
(2020) American Association for Cancer Research. 2020
D Barua, A Sultana, MN Islam, A Gupta, S Gupta (2020) XBP1 regulates the expression of cell cycle associated genes in ERα positive breast cancer cells. Cancer Research 80 (16 Supplement), 5843-5843 American Association for Cancer Research. 2020 [Details]
(2016) The European Association for Cancer Research is hosting EACR24 in Manchester, UK on July 9-12, 2016
Sanjeev Gupta, Ananya Gupta, Muhammad Mosaraf Hossain, Grace Callagy, Michael Kerin (2016) XBP1 modulates luminal breast cancer by transcriptional regulation of SRC-3 during estrogen signaling. European Journal of Cancer 2016; 61 (Supplement 1): S166 The European Association for Cancer Research is hosting EACR24 in Manchester, UK on July 9-12, 2016 [Details]

Other Journals

  Year Publication
(2020) '1. Downregulation of miR-17-92 cluster by PERK fine-tunes unfolded protein response mediated apoptosis'
Danielle E. Read, Ananya Gupta, Karen Cawley, Laura Fontana, Patrizia Agostinis, Afshin Samali, Sanjeev Gupta (2020) '1. Downregulation of miR-17-92 cluster by PERK fine-tunes unfolded protein response mediated apoptosis' BioRxiv, . [DOI] [Details]
(2015) 'Loss of Dicer1 in mouse embryonic fibroblasts impairs ER stress-induced apoptosis'
A Gupta, D Read, D Oommen, A Samali, S Gupta (2015) 'Loss of Dicer1 in mouse embryonic fibroblasts impairs ER stress-induced apoptosis' BioRxiv, . [Details]
(2016) 'Reduced CREB3L2 expression is associated with resistance to sorafenib and poor prognosis in ER-positive breast cancer'
S Mullarkey, V Arabkari, MM Hossain, S Gupta, A Gupta (2016) 'Reduced CREB3L2 expression is associated with resistance to sorafenib and poor prognosis in ER-positive breast cancer' BioRxiv, . [Details]

Conference Contributions

  Year Publication
(2013) BELPSO Meeting,
Logue SE, Deegan S, Saveljeva S, Pakos-Zebrucka K, Gupta S, Vandenabeele P, Bertrand MJ, Samali A. (2013) Deficiency in the mitochondrial apoptotic pathway reveals the toxic potential of autophagy under ER stress conditions. [Oral Presentation], BELPSO Meeting, Ghent , 04-APR-13 - 06-APR-13. [Details]
(2011) Annual IAS Meeting 2011- Protein folding and misfolding: mechanisms and consequences,
Sanjeev Gupta (2011) Unfolded Protein Response: Jekyll and Hyde in cancer progression. [Invited Oral Presentation], Annual IAS Meeting 2011- Protein folding and misfolding: mechanisms and consequences, Glenroyal Hotel/National University of Ireland, Ireland , 01-DEC-11 - 03-FEB-12. [Details]
(2011) FASEB SUMMER RESEARCH CONFERENCE:From Unfolded Proteins in the ER to Disease,
Sanjeev Gupta (2011) Perk-dependent Repression of miR-106b-25 Cluster is required for ER stress-induced Apoptosis. [Invited Oral Presentation], FASEB SUMMER RESEARCH CONFERENCE:From Unfolded Proteins in the ER to Disease, VERMONT ACADEMY, Saxtons River, Vermont, USA , 12-JUN-11 - 17-FEB-12. [Details]
(2011) 8th World Congress on Trauma, Shock, Inflammation and Sepsis,
Sanjeev Gupta (2011) Pathologic Impact of ER Stress: regulation by Hsp72. [Invited Oral Presentation], 8th World Congress on Trauma, Shock, Inflammation and Sepsis, Munich/Germany , 09-MAR-11 - 13-MAR-11. [Details]

Reviews

  Year Publication
(2020) Targeting the IRE1-XBP1 axis to overcome endocrine resistance in breast cancer: Opportunities and challenges.
Barua, D;Gupta, A;Gupta, S (2020) Targeting the IRE1-XBP1 axis to overcome endocrine resistance in breast cancer: Opportunities and challenges. CLARE: ELSEVIER IRELAND LTD Reviews [DOI] [Details]
(2009) Bcl-2 family on guard at the ER.
Szegezdi, E;MacDonald, DC;Chonghaile, TN;Gupta, S;Samali, A (2009) Bcl-2 family on guard at the ER. BETHESDA: AMER PHYSIOLOGICAL SOC Reviews [DOI] [Details]
(2009) Targeting the endoplasmic reticulum-stress response as an anticancer strategy.
Healy, SJM;Gorman, AM;Mousavi-Shafaei, P;Gupta, S;Samali, A (2009) Targeting the endoplasmic reticulum-stress response as an anticancer strategy. AMSTERDAM: ELSEVIER SCIENCE BV Reviews [DOI] [Details]
(2009) The mitochondrial death pathway: a promising therapeutic target in diseases.
Gupta, S;Kass, GEN;Szegezdi, E;Joseph, B (2009) The mitochondrial death pathway: a promising therapeutic target in diseases. HOBOKEN: WILEY Reviews [DOI] [Details]
(2013) The eIF2 alpha kinases: their structures and functions.
Donnelly, N;Gorman, AM;Gupta, S;Samali, A (2013) The eIF2 alpha kinases: their structures and functions. BASEL: SPRINGER BASEL AG Reviews [DOI] [Details]

Honours and Awards

  Year Title Awarding Body
2000 ASCB pre-doctoral travel award American Society for Cell Biology
1999 Senior Research Fellowship Council for Scientific and Industrial Research-University Grants Commission (INDIA)
1997 Junior Research Fellowship Council for Scientific and Industrial Research-University Grants Commission (INDIA)

Employment

  Employer Position From / To
Thomas Jefferson University, Philadelphia, USA Post-doctoral Researcher 01-FEB-03 /
Indian Institute of Techonology, Madras Assistant Professor 25-APR-06 / 31-AUG-07
National University of Ireland, Galway Lecturer 01-OCT-10 /
National University of Ireland, Galway Senior Researcher 10-SEP-07 / 31-JAN-10
University of Pennsylvania, Philadelphia, USA Post-doctoral Researcher 01-OCT-04 / 24-APR-06

Education

  Year Institution Qualification Subject
1994 Hamdard University MSc Biochemistry
1991 Delhi University BSc Biology
2002 Jawaharlal Nehru Univesity PhD Moelcular & Cell Biology
2019 NUI Galway PG Certificate Teaching & Learning

Current Postgraduate Students (Taught)

  Name Degree Primary Supervisor
Fergus Cox Msc Y

Recent Postgraduate Students

  Graduation Name Degree Primary Supervisor
2015 Alan ODwyer Msc Y
2018 Muhammad Mosaraf Hossain PhD Y
2019 Vahid Arabkari PhD Y
2020 Cian Mulqueen Msc Y
2020 Eoghan Gubbins-Clooney Msc Y
2021 David Barua PhD Y
2018 Anshika Lall MSc in Biomedical Science Y
2016 Saraswathi Rajakumar Msc Y
2020 Jodie Fahy MSc in Biomedical Science Y
2020 Martin Gordon MSc (Biomedical Genomics) Y
2017 Hariprasath Rakasekaran MSc in Biomedical Science Y
2016 Anhar Alabdulhai Msc Y
2014 Siobhan Kenny Msc Y
2012 Louis Conlon Msc Y

Modules Taught

  Term/Year Module Title Module Code Subject / Desc
2016-17 Health & Disease I MD201
2016-17 Health & Disease II MD302
2016-17 Elements of Pathology PA405
2016-17 Biological Sciences III NU306
2016-17 Research project (Cancer Biology) BI464
2016-17 Research project (Pharmacology) PM431
2016-17 Clinical Oncology & hematology BI461
2016-17 Research project (Biomedical Sci) BES556
2016-17 Research project (Cancer Biology) BI465
2016-17 Research project (Physiology) SI435

Internal Collaborators

  Name Description of Collaboration
Michael Kerin
Ananya Gupta
Patrizia Agostinis
Grace Callagy
Abhay Pandit
Martin O Halloran