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Medicine

Dr Oliver Treacy

B.Sc.,M.Sc.

Contact Details

Lecturer Above The Bar
Discipline of Pharmacology and T
Lambe Institute for Translationa
Costello Road,
University of Galway
E: OLIVER.TREACY@nuigalway.ie
 
researcher
 

Biography

Dr Oliver Treacy is a Lecturer Above the Bar in the Discipline of Pharmacology and Therapeutics at the University of Galway. He obtained his BSc (Hons) in Microbiology in 2005 and MSc in Regenerative Medicine in 2009 from NUIG. Prior to completing his Master's degree, he worked for Abbott Ireland (now Abbvie) based in Co. Sligo. Following completion of his Master's degree, he pursued a PhD in transplant immunology investigating the ability of mesenchymal stromal cells (MSCs) to prolong corneal allograft survival. He graduated from the University of Galway with his degree in 2014. Oliver continued his work in the area of transplant immunology in a postdoctoral position funded by SFI, with a focus on enhancing the therapeutic efficacy of MSCs through licensing. In 2017, he joined the lab of Dr Aideen Ryan on a SFI-funded project aimed at identifying novel stromal cell-related immunotherapeutic targets for the treatment of metastatic colon cancer. The focus of his current work is to investigate the role of stromal cell-derived immune checkpoint marker expression in the context of colon cancer development and metastasis. Dr. Treacy's work has led to a number of significant publications describing novel discoveries in Cancer Immunology Research, Molecular Therapy, the American Journal of Transplantation and Stem Cells. In 2020, Dr Treacy received a Mobility Award from the Irish Association for Cancer Research (IACR) funded by the Association of Irish Floral Artists (AOIFA) and was awarded the European Association for Cancer Research (EACR) Young Scientist Award in 2021.

Peer Reviewed Journals

  Year Publication
(2023) 'Targeting stromal cell sialylation reverses T cell-mediated immunosuppression in the tumor microenvironment'
Egan, H; Treacy, O; Lynch, K; Leonard, NA; O'Malley, G; Reidy, E; O'Neill, A; Corry, SM; De Veirman, K; Vanderkerken, K; Egan, LJ; Ritter, T; Hogan, AM; Redmond, K; Peng, L; Che, J; Gatlin, W; Jayaraman, P; Sheehan, M; Canney, A; Hynes, SO; Kerr, EM; Dunne, PD; O'Dwyer, ME; Ryan, AE. (2023) 'Targeting stromal cell sialylation reverses T cell-mediated immunosuppression in the tumor microenvironment'. Cell Reports, [DOI] [Details]
(2021) 'A 3D View of Colorectal Cancer Models in Predicting Therapeutic Responses and Resistance'
Reidy E, Leonard NA, Treacy O, Ryan AE. (2021) 'A 3D View of Colorectal Cancer Models in Predicting Therapeutic Responses and Resistance'. Cancers (Basel)Cancers (Basel), [Details]
(2021) 'Cyclophosphamide alters the tumor cell secretome to potentiate the anti-myeloma activity of daratumumab through augmentation of macrophage-mediated antibody dependent cellular phagocytosis'
Naicker SD, Feerick CL, Lynch K, Swan D, McEllistrim C, Henderson R, Leonard NA, Treacy O, Natoni A, Rigalou A, Cabral J, Chiu C, Sasser K, Ritter T, O'Dwyer M, Ryan AE. (2021) 'Cyclophosphamide alters the tumor cell secretome to potentiate the anti-myeloma activity of daratumumab through augmentation of macrophage-mediated antibody dependent cellular phagocytosis'. Oncoimmunology, [Details]
(2021) 'Subconjunctival administration of low-dose murine allogeneic mesenchymal stromal cells promotes corneal allograft survival in mice'
Treacy O, Lynch K, Murphy N, Chen X, Donohoe E, Canning A, Lohan P, Shaw G, Fahy G, Ryan AE, Ritter T. (2021) 'Subconjunctival administration of low-dose murine allogeneic mesenchymal stromal cells promotes corneal allograft survival in mice'. Stem Cell Research & Therapy, [Details]
(2020) 'TGF-ß1-Licensed Murine MSCs Show Superior Therapeutic Efficacy in Modulating Corneal Allograft Immune Rejection In Vivo'
Lynch K, Treacy O, Chen X, Murphy N, Lohan P, Islam MN, Donohoe E, Griffin MD, Watson L, McLoughlin S, O'Malley G, Ryan AE, Ritter T. (2020) 'TGF-ß1-Licensed Murine MSCs Show Superior Therapeutic Efficacy in Modulating Corneal Allograft Immune Rejection In Vivo'. Molecular Therapy, [Details]
(2019) 'TNF-¿/IL-1ß-licensed mesenchymal stromal cells promote corneal allograft survival via myeloid cell-mediated induction of Foxp3 + regulatory T cells in the lung'
Murphy N, Treacy O, Lynch K, Morcos M, Lohan P, Howard L, Fahy G, Griffin MD, Ryan AE, Ritter T. (2019) 'TNF-¿/IL-1ß-licensed mesenchymal stromal cells promote corneal allograft survival via myeloid cell-mediated induction of Foxp3 + regulatory T cells in the lung'. Faseb J, [Details]
(2018) 'Interspecies Incompatibilities Limit the Immunomodulatory Effect of Human Mesenchymal Stromal Cells in the Rat'
Lohan P, Treacy O, Morcos M, Donohoe E, O'donoghue Y, Ryan AE, Elliman SJ, Ritter T, Griffin MD. (2018) 'Interspecies Incompatibilities Limit the Immunomodulatory Effect of Human Mesenchymal Stromal Cells in the Rat'. Stem Cells, [Details]
(2018) 'Stromal Cell PD-L1 Inhibits CD8 + T-cell Antitumor Immune Responses and Promotes Colon Cancer'
O'Malley G, Treacy O, Lynch K, Naicker SD, Leonard NA, Lohan P, Dunne PD, Ritter T, Egan LJ, Ryan AE. (2018) 'Stromal Cell PD-L1 Inhibits CD8 + T-cell Antitumor Immune Responses and Promotes Colon Cancer'. Cancer Immunology Research, [Details]
(2018) 'Third-Party Allogeneic Mesenchymal Stromal Cells Prevent Rejection in a Pre-sensitized High-Risk Model of Corneal Transplantation'
Lohan P, Murphy N, Treacy O, Lynch K, Morcos M, Chen B, Ryan AE, Griffin MD, Ritter T. (2018) 'Third-Party Allogeneic Mesenchymal Stromal Cells Prevent Rejection in a Pre-sensitized High-Risk Model of Corneal Transplantation'. Frontiers In Immunology, [Details]
(2017) 'Regulating Immunogenicity and Tolerogenicity of Bone Marrow-Derived Dendritic Cells through Modulation of Cell Surface Glycosylation by Dexamethasone Treatment'
Lynch K, Treacy O, Gerlach JQ, Annuk H, Lohan P, Cabral J, Joshi L, Ryan AE, Ritter T. (2017) 'Regulating Immunogenicity and Tolerogenicity of Bone Marrow-Derived Dendritic Cells through Modulation of Cell Surface Glycosylation by Dexamethasone Treatment'. Frontiers In Immunology, [Details]
(2017) 'Anti-Donor Immune Responses Elicited by Allogeneic Mesenchymal Stem Cells and Their Extracellular Vesicles: Are We Still Learning?'
Lohan P, Treacy O, Griffin MD, Ritter T, Ryan AE. (2017) 'Anti-Donor Immune Responses Elicited by Allogeneic Mesenchymal Stem Cells and Their Extracellular Vesicles: Are We Still Learning?'. Frontiers In Immunology, [Details]
(2016) 'Corneal Immunosuppressive Mechanisms, Anterior Chamber-Associated Immune Deviation (ACAID) and Their Role in Allograft Rejection'
Treacy O, Fahy G, Ritter T, O'Flynn L. (2016) 'Corneal Immunosuppressive Mechanisms, Anterior Chamber-Associated Immune Deviation (ACAID) and Their Role in Allograft Rejection'. Methods in Molecular Biology, [Details]
(2016) 'Mesenchymal stem cell therapy to promote corneal allograft survival: current status and pathway to clinical translation'
Murphy N, Lynch K, Lohan P, Treacy O, Ritter T. (2016) 'Mesenchymal stem cell therapy to promote corneal allograft survival: current status and pathway to clinical translation'. Current Opinion In Organ Transplantation, [Details]
(2016) 'Culture expanded primary chondrocytes have potent immunomodulatory properties and do not induce an allogeneic immune response'
Lohan, P; Treacy, O; Lynch, K; Barry, F; Murphy, M; Griffin, MD; Ritter, T; Ryan, AE. (2016) 'Culture expanded primary chondrocytes have potent immunomodulatory properties and do not induce an allogeneic immune response'. Osteoarthritis And Cartilage, [Details]
(2014) 'Mesenchymal stem cell therapy promotes corneal allograft survival in rats by local and systemic immunomodulation'
Treacy, O; O'Flynn, L; Ryan, AE; Morcos, M; Lohan, P; Schu, S; Wilk, M; Fahy, G; Griffin, MD; Nosov, M; Ritter, T. (2014) 'Mesenchymal stem cell therapy promotes corneal allograft survival in rats by local and systemic immunomodulation'. American Journal Of Transplantation, [Details]
(2014) 'Chondrogenic differentiation increases antidonor immune response to allogeneic mesenchymal stem cell transplantation'
Ryan, AE; Lohan, P; O'Flynn, L; Treacy, O; Chen, X; Coleman, C; Shaw, G; Murphy, M; Barry, F; Griffin, MD; Ritter, T. (2014) 'Chondrogenic differentiation increases antidonor immune response to allogeneic mesenchymal stem cell transplantation'. Molecular Therapy, [Details]
(2013) 'Donor bone marrow-derived dendritic cells prolong corneal allograft survival and promote an intragraft immunoregulatory milieu'
O'Flynn, L; Treacy, O; Ryan, AE; Morcos, M; Cregg, M; Gerlach, J; Joshi, L; Nosov, M; Ritter, T. (2013) 'Donor bone marrow-derived dendritic cells prolong corneal allograft survival and promote an intragraft immunoregulatory milieu'. Molecular Therapy, [Details]
(2013) 'Anti-donor immune responses elicited by allogeneic mesenchymal stem cells: what have we learned so far?'
Griffin, MD; Ryan, AE; Alagesan, S; Lohan, P; Treacy, O; Ritter, T. (2013) 'Anti-donor immune responses elicited by allogeneic mesenchymal stem cells: what have we learned so far?'. Immunology And Cell Biology, [Details]
(2012) 'Role of lentivirus-mediated overexpression of programmed death-ligand 1 on corneal allograft survival'
Nosov, M; Wilk, M; Morcos, M; Cregg, M; O'Flynn, L; Treacy, O; Ritter, T. (2012) 'Role of lentivirus-mediated overexpression of programmed death-ligand 1 on corneal allograft survival'. American Journal Of Transplantation, [Details]
(2012) 'Adenoviral transduction of mesenchymal stem cells: in vitro responses and in vivo immune responses after cell transplantation'
Treacy, O; Ryan, AE; Heinzl, T; O'Flynn, L; Cregg, M; Wilk, M; Odoardi, F; Lohan, P; O'Brien, T; Nosov, M; Ritter, T. (2012) 'Adenoviral transduction of mesenchymal stem cells: in vitro responses and in vivo immune responses after cell transplantation'. Plos One, [Details]
(2012) 'Immunogenicity of allogeneic mesenchymal stem cells'
Schu S; Nosov, M; O'Flynn, L; Shaw, G; Treacy, O; Barry, F; Murphy, M; O'Brien, T; Ritter, T. (2012) 'Immunogenicity of allogeneic mesenchymal stem cells'. Journal Of Cellular And Molecular Medicine, [Details]

Book Chapters

  Year Publication
(2016) 'Corneal Immunosuppressive Mechanisms, Anterior Chamber-Associated Immune Deviation (ACAID) and Their Role in Allograft Rejection'
Treacy, O; Fahy, G; Ritter, T; O'Flynn, L. (2016) 'Corneal Immunosuppressive Mechanisms, Anterior Chamber-Associated Immune Deviation (ACAID) and Their Role in Allograft Rejection' In: Suppression and Regulation of Immune Responses. New York: Springer New York. [Details]

Honours and Awards

  Year Title Awarding Body
2021 European Association for Cancer Research (EACR) Young Scientist Award Irish Association for Cancer Research
2021 Hospital Professional News Top 100 Hospital Professional News
2020 IACR Mobility Award Irish Association for Cancer Research
2019 Best Cancer Research Publication of 2018 Irish Cancer Society

Professional Associations

  Association Function From / To
Society for Immunotherapy of Cancer Member 05-NOV-20 /
Irish Association for Cancer Research (IACR) Junior Council Member 01-MAY-19 /
Association for Research in Vision and Ophthalmology Member 07-NOV-11 / 30-MAY-17
Irish Society for Immunology Member 01-MAR-14 /
European Association for Cancer Research Member 01-MAY-19 /

Committees

  Committee Function From / To
School of Medicine Research Committee Committee member 15-JAN-22 /

Employment

  Employer Position From / To
Dr Aideen Ryan, NUI Galway Senior Postdoctoral Researcher 01-SEP-17 /
Prof Thomas Ritter, NUI Galway Postdoctoral Researcher 01-SEP-13 / 31-AUG-17

Education

  Year Institution Qualification Subject
2005 NUI Galway BSc (Hons) Microbiology
2014 NUI Galway PhD Medicine
2009 NUI Galway MSc Regenerative Medicine

Community Engagement

  Title Type From / To
Outreach Cell Explorers School Visit 01-NOV-17 /
Outreach Open House Lunch and Learn 09-MAY-19 /

Reviews

  Journal Role
Journal Of Cellular And Molecular Medicine Reviewer
Cancers (Basel)Cancers (Basel) Reviewer
American Journal Of Physiology-Cell Physiology Reviewer
Stem Cell Research & Therapy Reviewer
Peerj Reviewer

Modules Taught

  Term/Year Module Title Module Code Subject / Desc
2019/2020 Gene and Cell Therapy MD507
2020/2021 Basic and Advanced Immunology REM508
2021/2022 Gene and Cell Therapy MD507
2021/2022 Basic and Advanced Immunology REM508
2019/2020 Basic and Advanced Immunology REM508
2020/2021 Gene and Cell Therapy MD507