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Medicine

Ms Manon Jammes

BSc, MSc

Contact Details

Postdoctoral Researcher
T: +353894938044
E: manon.jammes@universityofgalway.ie

Biography

Dr. Manon Jammes joined the Restore Vision project as a postdoctoral research fellow in the Ritter group of the University of Galway (Ireland). She recently completed a PhD at the University of Caen (France) on the therapeutic use of the secretome and the exosomes derived from mesenchymal stem cells (MSCs) for the regeneration of hyaline cartilage in horses.With knowledge and skills focusing on the various production, isolation and purification methods of extracellular vesicles (EVs), Manon¿s contribution to the RESTORE VISION project lies in the development of clinical grade MSC-derived EVs to prevent and reduce ocular surface inflammation associated with RED physiopathology. Her work also aims to investigate the mechanism of action of these MSC derivatives to improve the understanding of the mediation of their therapeutic effect.

Research Projects

	Project	Start Date	End Date
	Restore Vision	01-MAY-23	30-APR-27

Reviews

	Year	Publication
	(2023)	Equine osteoarthritis: Strategies to enhance mesenchymal stromal cell-based acellular therapies. Manon Jammes, Romain Contentin, Frédéric Cassé, Philippe Galéra (2023) Equine osteoarthritis: Strategies to enhance mesenchymal stromal cell-based acellular therapies. Reviews [DOI] [Details]

Research Paper

	Year	Publication
	(2023)	Pro-inflammatory cytokine priming and purification method modulate the impact of exosomes derived from equine bone marrow mesenchymal stromal cells on equine articular chondrocytes. Manon Jammes, Frédéric Cassé, Emilie Velot, Arnaud Bianchi, Fabrice Audigié, Romain Contentin, Philippe Galéra (2023) Pro-inflammatory cytokine priming and purification method modulate the impact of exosomes derived from equine bone marrow mesenchymal stromal cells on equine articular chondrocytes. Research Paper [DOI] [Details]
	(2023)	Effect of pro-inflammatory cytokine priming and storage temperature of the mesenchymal stromal cell (MSC) secretome on equine articular chondrocytes. Manon Jammes, Romain Contentin, Fabrice Audigié, Frédéric Cassé, Philippe Galéra (2023) Effect of pro-inflammatory cytokine priming and storage temperature of the mesenchymal stromal cell (MSC) secretome on equine articular chondrocytes. Research Paper [DOI] [Details]
	(2023)	MiR-4270 acts as a tumor suppressor by directly targeting Bcl-xL in human osteosarcoma cells. Clément Veys, Flavie Boulouard, Abderrahim Benmoussa, Manon Jammes, Emilie Brotin, Francoise Redini, Laurent Poulain, Nicolas Gruchy, Christophe Denoyelle, Florence Legendre, Philippe Galera (2023) MiR-4270 acts as a tumor suppressor by directly targeting Bcl-xL in human osteosarcoma cells. Research Paper [DOI] [Details]
	(2022)	Tumor Suppressive Role of miR-342-5p and miR-491-5p in Human Osteosarcoma Cells. Clément Veys, Manon Jammes, Françoise Rédini, Laurent Poulain, Christophe Denoyelle, Florence Legendre, Philippe Galera (2022) Tumor Suppressive Role of miR-342-5p and miR-491-5p in Human Osteosarcoma Cells. Research Paper [DOI] [Details]
	(2022)	Bone Marrow MSC Secretome Increases Equine Articular Chondrocyte Collagen Accumulation and Their Migratory Capacities. Romain Contentin, Manon Jammes, Bastien Bourdon, Frédéric Cassé, Arnaud Bianchi, Fabrice Audigié, Thomas Branly, Émilie Velot, Philippe Galéra (2022) Bone Marrow MSC Secretome Increases Equine Articular Chondrocyte Collagen Accumulation and Their Migratory Capacities. Research Paper [DOI] [Details]

Employment

Employer	Position	From / To
University of Caen	PhD student	05-OCT-20 / 13-OCT-23
LABEO (St Contest, France)	Laboratory technician	03-JUL-17 / 28-JUL-17
University of Caen	Master's student	13-JAN-20 / 26-JUN-20
LABEO (St Contest, France)	Bachelor's student	23-APR-17 / 30-JUN-17
University of Caen	Master's student	18-MAR-19 / 07-JUN-19

Education

Year	Institution	Qualification	Subject
2023	University of Caen, France	PhD	Cellular and Molecular Biology
2018	University of Caen, France	Bachelor degree, Biology	Sciences for Health and Biotechnologies
2020	University of Caen, France	Master degree, Biology	Cancer, Differentiation Genetics and Biotherapies
2017	University Institute of Technology of Caen, France	University degree in technology, Biology	Biological and Biochemical analysis

Languages

	Language
	English
	French

Recent Postgraduate Students

	Graduation	Name	Degree	Primary Supervisor
	2024	Yedizza Rautavaara	Master in Biology

Modules Taught

	Term/Year	Module Title	Module Code	Subject / Desc
	University degree in technology, 2nd year		Cell culture
	University degree in technology, 1rst year		Cardiology
	Bachelor, 3rd year		Gene regulation
	University degree in technology, 1rst year		Physiology of digestion
	University degree in technology, 1rst year		Nephrology