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University Life
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About University of Galway
About University of Galway
Since 1845, University of Galway has been sharing the highest quality teaching and research with Ireland and the world. Find out what makes our University so special – from our distinguished history to the latest news and campus developments.
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Colleges & Schools
Colleges & Schools
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Research & Innovation
Research & Innovation
University of Galway’s vibrant research community take on some of the most pressing challenges of our times.
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Business & Industry
Guiding Breakthrough Research at University of Galway
We explore and facilitate commercial opportunities for the research community at University of Galway, as well as facilitating industry partnership.
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Community Engagement
Community Engagement
At University of Galway, we believe that the best learning takes place when you apply what you learn in a real world context. That's why many of our courses include work placements or community projects.
Accessibility & LanguageMedicine
PROF GARRY DUFFY
BSc (Hons)
Biography
Peer Reviewed Journals
| Year | Publication | |
|---|---|---|
| (2018) | 'Towards Alternative Approaches for Coupling of a Soft Robotic Sleeve to the Heart'
Mencía Castaño, Curtin CM, Duffy GP, O'Brien FJ (2018) 'Towards Alternative Approaches for Coupling of a Soft Robotic Sleeve to the Heart'. Tissue Engineering Part A, [DOI] [Details] |
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| (2018) | 'A collagen cardiac patch incorporating alginate microparticles permits the controlled release of hepatocyte growth factor and insulin-like growth factor-1 to enhance cardiac stem cell migration and proliferation'
O'Neill, HS;O'Sullivan, J;Porteous, N;Ruiz-Hernandez, E;Kelly, HM;O'Brien, FJ;Duffy, GP (2018) 'A collagen cardiac patch incorporating alginate microparticles permits the controlled release of hepatocyte growth factor and insulin-like growth factor-1 to enhance cardiac stem cell migration and proliferation'. Journal Of Tissue Engineering And Regenerative Medicine, 12 :384-394 [DOI] [Details] |
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| (2018) | 'Sustained release of targeted cardiac therapy with a replenishable implanted epicardial reservoir'
Whyte, W;Roche, ET;Varela, CE;Mendez, K;Islam, S;O'Neill, H;Weafer, F;Shirazi, RN;Weaver, JC;Vasilyev, NV;McHugh, PE;Murphy, B;Duffy, GP;Walsh, CJ;Mooney, DJ (2018) 'Sustained release of targeted cardiac therapy with a replenishable implanted epicardial reservoir'. Nature Biomedical Engineering, 2 :416-428 [DOI] [Details] |
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| (2018) | 'Optimization of cell growth on palmitoyl-hyaluronan knitted scaffolds developed for tissue engineering applications'
Sogorkova, J;Zapotocky, V;Cepa, M;Stepankova, V;Vagnerova, H;Batova, J;Pospisilova, M;Betak, J;Nesporova, K;Hermannova, M;Daro, D;Duffy, G;Velebny, V (2018) 'Optimization of cell growth on palmitoyl-hyaluronan knitted scaffolds developed for tissue engineering applications'. Journal Of Biomedical Materials Research Part A, 106 :1488-1499 [DOI] [Details] |
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| (2017) | 'Direct UV-Triggered Thiol-ene Cross-Linking of Electrospun Polyester Fibers from Unsaturated Poly(macrolactone)s and Their Drug Loading by Solvent Swelling'
de Oliveira, FCS;Olvera, D;Sawkins, MJ;Cryan, SA;Kimmins, SD;da Silva, TE;Kelly, DJ;Duffy, GP;Kearney, C;Heise, A (2017) 'Direct UV-Triggered Thiol-ene Cross-Linking of Electrospun Polyester Fibers from Unsaturated Poly(macrolactone)s and Their Drug Loading by Solvent Swelling'. Biomacromolecules, 18 :4292-4298 [DOI] [Details] |
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| (2017) | 'Olfactory Derived Stem Cells Delivered in a Biphasic Conduit Promote Peripheral Nerve Repair In Vivo'
Roche, P;Alekseeva, T;Widaa, A;Ryan, A;Matsiko, A;Walsh, M;Duffy, GP;O'Brien, FJ (2017) 'Olfactory Derived Stem Cells Delivered in a Biphasic Conduit Promote Peripheral Nerve Repair In Vivo'. Stem Cells Translational Medicine, 6 :1894-1904 [DOI] [Details] |
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| (2017) | 'Advances in polymeric islet cell encapsulation technologies to limit the foreign body response and provide immunoisolation'
Ryan, AJ;O'Neill, HS;Duffy, GP;O'Brien, FJ (2017) 'Advances in polymeric islet cell encapsulation technologies to limit the foreign body response and provide immunoisolation'. Current Opinion In Pharmacology, 36 :66-71 [DOI] [Details] |
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| (2017) | 'A stimuli responsive liposome loaded hydrogel provides flexible on-demand release of therapeutic agents'
O'Neill, HS;Herron, CC;Hastings, CL;Deckers, R;Noriega, AL;Kelly, HM;Hennink, WE;McDonnell, CO;O'Brien, FJ;Ruiz-Hernandez, E;Duffy, GP (2017) 'A stimuli responsive liposome loaded hydrogel provides flexible on-demand release of therapeutic agents'. Acta Biomaterialia, 48 :110-119 [DOI] [Details] |
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| (2017) | 'An in vitro investigation to assess procedure parameters for injecting therapeutic hydrogels into the myocardium'
Curley, CJ;Dolan, EB;Cavanagh, B;O'Sullivan, J;Duffy, GP;Murphy, BP (2017) 'An in vitro investigation to assess procedure parameters for injecting therapeutic hydrogels into the myocardium'. Journal Of Biomedical Materials Research Part B-Applied Biomaterials, 105 :2618-2629 [DOI] [Details] |
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| (2017) | 'Fabrication of biodegradable textile scaffold based on hydrophobized hyaluronic acid'
Zapotocky, V;Pospisilova, M;Janouchova, K;Svadlak, D;Batova, J;Sogorkova, J;Cepa, M;Betak, J;Stepankova, V;Sulakova, R;Kulhanek, J;Pitucha, T;Vranova, J;Duffy, G;Velebny, V (2017) 'Fabrication of biodegradable textile scaffold based on hydrophobized hyaluronic acid'. International Journal Of Biological Macromolecules, 95 :903-909 [DOI] [Details] |
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| (2016) | 'Next generation bone tissue engineering: non-viral miR-133a inhibition using collagen-nanohydroxyapatite scaffolds rapidly enhances osteogenesis'
Castano, IM;Curtin, CM;Duffy, GP;O'Brien, FJ (2016) 'Next generation bone tissue engineering: non-viral miR-133a inhibition using collagen-nanohydroxyapatite scaffolds rapidly enhances osteogenesis'. Scientific Reports, 6 [DOI] [Details] |
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| (2016) | 'Effect of collagen-glycosaminoglycan scaffold pore size on matrix mineralization and cellular behavior in different cell types'
Murphy, CM;Duffy, GP;Schindeler, A;O'brien, FJ (2016) 'Effect of collagen-glycosaminoglycan scaffold pore size on matrix mineralization and cellular behavior in different cell types'. Journal Of Biomedical Materials Research Part A, 104 :291-304 [DOI] [Details] |
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| (2016) | 'Delivering Nucleic-Acid Based Nanomedicines on Biomaterial Scaffolds for Orthopedic Tissue Repair: Challenges, Progress and Future Perspectives'
Raftery, RM;Walsh, DP;Castano, IM;Heise, A;Duffy, GP;Cryan, SA;O'Brien, FJ (2016) 'Delivering Nucleic-Acid Based Nanomedicines on Biomaterial Scaffolds for Orthopedic Tissue Repair: Challenges, Progress and Future Perspectives'. Advanced Materials (Deerfield Beach, Fla.), 28 :5447-5469 [DOI] [Details] |
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| (2015) | 'Investigating the effect of hypoxic culture on the endothelial differentiation of human amniotic fluid-derived stem cells'
Lloyd-Griffith, C;Duffy, GP;O'Brien, FJ (2015) 'Investigating the effect of hypoxic culture on the endothelial differentiation of human amniotic fluid-derived stem cells'. Journal Of Anatomy, 227 :767-780 [DOI] [Details] |
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| (2015) | 'A novel collagen-nanohydroxyapatite microRNA-activated scaffold for tissue engineering applications capable of efficient delivery of both miR-mimics and antagomiRs to human mesenchymal stem cells'
Castano, IM;Curtin, CM;Shaw, G;Murphy, JM;Duffy, GP;O'Brien, FJ (2015) 'A novel collagen-nanohydroxyapatite microRNA-activated scaffold for tissue engineering applications capable of efficient delivery of both miR-mimics and antagomiRs to human mesenchymal stem cells'. Journal Of Controlled Release, 200 :42-51 [DOI] [Details] |
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| (2015) | 'Combinatorial Gene Therapy Accelerates Bone Regeneration: Non-Viral Dual Delivery of VEGF and BMP2 in a Collagen-Nanohydroxyapatite Scaffold'
Curtin, CM;Tierney, EG;McSorley, K;Cryan, SA;Duffy, GP;O'Brien, FJ (2015) 'Combinatorial Gene Therapy Accelerates Bone Regeneration: Non-Viral Dual Delivery of VEGF and BMP2 in a Collagen-Nanohydroxyapatite Scaffold'. Advanced Healthcare Materials, 4 :223-227 [DOI] [Details] |
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| (2015) | 'THE EFFECT OF BISPHOSPHONATE TREATMENT ON THE BIOCHEMICAL AND CELLULAR EVENTS DURING BONE REMODELLING IN RESPONSE TO MICROINJURY STIMULATION'
Mulcahy, LE;Curtin, CM;McCoy, RJ;O'Brien, FJ;Taylor, D;Lee, TC;Duffy, GP (2015) 'THE EFFECT OF BISPHOSPHONATE TREATMENT ON THE BIOCHEMICAL AND CELLULAR EVENTS DURING BONE REMODELLING IN RESPONSE TO MICROINJURY STIMULATION'. European Cells & Materials, 30 :271-281 [Details] |
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| (2015) | 'The pre-vascularisation of a collagen-chondroitin sulphate scaffold using human amniotic fluid-derived stem cells to enhance and stabilise endothelial cell-mediated vessel formation'
Lloyd-Griffith, C;McFadden, TM;Duffy, GP;Unger, RE;Kirkpatrick, CJ;O'Brien, FJ (2015) 'The pre-vascularisation of a collagen-chondroitin sulphate scaffold using human amniotic fluid-derived stem cells to enhance and stabilise endothelial cell-mediated vessel formation'. Acta Biomaterialia, 26 :263-273 [DOI] [Details] |
|
| (2015) | 'Spatiotemporal delivery of small molecule therapeutics using a thermosensitive liposome loaded hydrogel'
O'Neill H, Herron C, Hastings C, Lopez-Noriega A, Kelly HM, O'Brien FJ, Ruiz-Hernandez E, Duffy GP. (2015) 'Spatiotemporal delivery of small molecule therapeutics using a thermosensitive liposome loaded hydrogel'. Journal Of Controlled Release, 213 :e28-e29 [DOI] [Details] |
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| (2014) | 'The application of a thermoresponsive chitosan/beta-GP gel to enhance cell repopulation of decellularized vascular scaffolds'
Sheridan, WS;Grant, OB;Duffy, GP;Murphy, BP (2014) 'The application of a thermoresponsive chitosan/beta-GP gel to enhance cell repopulation of decellularized vascular scaffolds'. Journal Of Biomedical Materials Research Part B-Applied Biomaterials, 102 :1700-1710 [DOI] [Details] |
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| (2014) | 'An Experimental Investigation of the Effect of Mechanical and Biochemical Stimuli on Cell Migration Within a Decellularized Vascular Construct'
Sheridan, WS;Ryan, AJ;Duffy, GP;O'Brien, FJ;Murphy, BP (2014) 'An Experimental Investigation of the Effect of Mechanical and Biochemical Stimuli on Cell Migration Within a Decellularized Vascular Construct'. Annals Of Biomedical Engineering, 42 :2029-2038 [DOI] [Details] |
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| (2014) | 'Enhanced delivery of microRNA mimics to cardiomyocytes using ultrasound responsive microbubbles reverses hypertrophy in an in-vitro model'
Gill, SL;O'Neill, H;McCoy, RJ;Logeswaran, S;O'Brien, F;Stanton, A;Kelly, H;Duffy, GP (2014) 'Enhanced delivery of microRNA mimics to cardiomyocytes using ultrasound responsive microbubbles reverses hypertrophy in an in-vitro model'. Technology And Health Care, 22 :37-51 [DOI] [Details] |
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| (2014) | 'Comparison of biomaterial delivery vehicles for improving acute retention of stem cells in the infarcted heart'
Roche, ET;Hastings, CL;Lewin, SA;Shvartsman, DE;Brudno, Y;Vasilyev, NV;O'Brien, FJ;Walsh, CJ;Duffy, GP;Mooney, DJ (2014) 'Comparison of biomaterial delivery vehicles for improving acute retention of stem cells in the infarcted heart'. Biomaterials, 35 :6850-6858 [DOI] [Details] |
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| (2014) | 'Hyperthermia-Induced Drug Delivery from Thermosensitive Liposomes Encapsulated in an Injectable Hydrogel for Local Chemotherapy'
Lopez-Noriega, A;Hastings, CL;Ozbakir, B;O'Donnell, KE;O'Brien, FJ;Storm, G;Hennink, WE;Duffy, GP;Ruiz-Hernandez, E (2014) 'Hyperthermia-Induced Drug Delivery from Thermosensitive Liposomes Encapsulated in an Injectable Hydrogel for Local Chemotherapy'. Advanced Healthcare Materials, 3 :854-859 [DOI] [Details] |
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| (2013) | 'Supramolecular Hydrogels with Reverse Thermal Gelation Properties from (Oligo)tyrosine Containing Block Copolymers'
Huang, J;Hastings, CL;Duffy, GP;Kelly, HM;Raeburn, J;Adams, DJ;Heise, A (2013) 'Supramolecular Hydrogels with Reverse Thermal Gelation Properties from (Oligo)tyrosine Containing Block Copolymers'. Biomacromolecules, 14 :200-206 [DOI] [Details] |
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| (2013) | 'High levels of ephrinB2 over-expression increases the osteogenic differentiation of human mesenchymal stem cells and promotes enhanced cell mediated mineralisation in a polyethyleneimine-ephrinB2 gene-activated matrix'
Tierney, EG;McSorley, K;Hastings, CL;Cryan, SA;O'Brien, T;Murphy, MJ;Barry, FP;O'Brien, FJ;Duffy, GP (2013) 'High levels of ephrinB2 over-expression increases the osteogenic differentiation of human mesenchymal stem cells and promotes enhanced cell mediated mineralisation in a polyethyleneimine-ephrinB2 gene-activated matrix'. Journal Of Controlled Release, 165 :173-182 [DOI] [Details] |
|
| (2013) | 'Encapsulation of cardiac stem cells in superoxide dismutase-loaded alginate prevents doxorubicin-mediated toxicity'
Liu, TCK;Ismail, S;Brennan, O;Hastings, C;Duffy, GP (2013) 'Encapsulation of cardiac stem cells in superoxide dismutase-loaded alginate prevents doxorubicin-mediated toxicity'. Journal Of Tissue Engineering And Regenerative Medicine, 7 :302-311 [DOI] [Details] |
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| (2013) | 'Non-viral gene-activated matrices Next generation constructs for bone repair'
Tierney, EG;Duffy, GP;Cryan, SA;Curtin, CM;O'Brien, FJ (2013) 'Non-viral gene-activated matrices Next generation constructs for bone repair'. Organogenesis, 9 :22-28 [DOI] [Details] |
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| (2013) | 'Orchestrating Osteogenic Differentiation of Mesenchymal Stem Cells-Identification of Placental Growth Factor as a Mechanosensitive Gene with a Pro-Osteogenic Role'
McCoy, RJ;Widaa, A;Watters, KM;Wuerstle, M;Stallings, RL;Duffy, GP;O'Brien, FJ (2013) 'Orchestrating Osteogenic Differentiation of Mesenchymal Stem Cells-Identification of Placental Growth Factor as a Mechanosensitive Gene with a Pro-Osteogenic Role'. Stem Cells (Dayton, Ohio), 31 :2420-2431 [DOI] [Details] |
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| (2013) | 'Optimum Parameters for Freeze-Drying Decellularized Arterial Scaffolds'
Sheridan, WS;Duffy, GP;Murphy, BP (2013) 'Optimum Parameters for Freeze-Drying Decellularized Arterial Scaffolds'. Tissue Engineering Part C-Methods, 19 :981-990 [DOI] [Details] |
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| (2013) | 'The delayed addition of human mesenchymal stem cells to pre-formed endothelial cell networks results in functional vascularization of a collagen-glycosaminoglycan scaffold in vivo'
McFadden, TM;Duffy, GP;Allen, AB;Stevens, HY;Schwarzmaier, SM;Plesnila, N;Murphy, JM;Barry, FP;Guldberg, RE;O'Brien, FJ (2013) 'The delayed addition of human mesenchymal stem cells to pre-formed endothelial cell networks results in functional vascularization of a collagen-glycosaminoglycan scaffold in vivo'. Acta Biomaterialia, 9 :9303-9316 [DOI] [Details] |
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| (2013) | 'Mesenchymal stem cells to augment therapeutic angiogenesis in hind-limb ischemia models: how important is their source?'
Duffy GP, Herron CC. (2013) 'Mesenchymal stem cells to augment therapeutic angiogenesis in hind-limb ischemia models: how important is their source?'. Stem Cell Research And Therapy, 4 :131-131 [DOI] [Details] |
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| (2012) | 'Mechanical characterization of a customized decellularized scaffold for vascular tissue engineering'
Sheridan, WS;Duffy, GP;Murphy, BP (2012) 'Mechanical characterization of a customized decellularized scaffold for vascular tissue engineering'. Journal Of The Mechanical Behavior Of Biomedical Materials, 8 :58-70 [DOI] [Details] |
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| (2012) | 'The development of non-viral gene-activated matrices for bone regeneration using polyethyleneimine (PEI) and collagen-based scaffolds'
Tierney, EG;Duffy, GP;Hibbitts, AJ;Cryan, SA;O'Brien, FJ (2012) 'The development of non-viral gene-activated matrices for bone regeneration using polyethyleneimine (PEI) and collagen-based scaffolds'. Journal Of Controlled Release, 158 :304-311 [DOI] [Details] |
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| (2012) | 'Innovative Collagen Nano-Hydroxyapatite Scaffolds Offer a Highly Efficient Non-Viral Gene Delivery Platform for Stem Cell-Mediated Bone Formation'
Curtin, CM;Cunniffe, GM;Lyons, FG;Bessho, K;Dickson, GR;Duffy, GP;O'Brien, FJ (2012) 'Innovative Collagen Nano-Hydroxyapatite Scaffolds Offer a Highly Efficient Non-Viral Gene Delivery Platform for Stem Cell-Mediated Bone Formation'. Advanced Materials (Deerfield Beach, Fla.), 24 [DOI] [Details] |
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| (2012) | 'Development of a thermoresponsive chitosan gel combined with human mesenchymal stem cells and desferrioxamine as a multimodal pro-angiogenic therapeutic for the treatment of critical limb ischaemia'
Hastings, CL;Kelly, HM;Murphy, MJ;Barry, FP;O'Brien, FJ;Duffy, GP (2012) 'Development of a thermoresponsive chitosan gel combined with human mesenchymal stem cells and desferrioxamine as a multimodal pro-angiogenic therapeutic for the treatment of critical limb ischaemia'. Journal Of Controlled Release, 161 :73-80 [DOI] [Details] |
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| (2011) | 'RANKL and OPG activity is regulated by injury size in networks of osteocyte-like cells'
Mulcahy, LE;Taylor, D;Lee, TC;Duffy, GP (2011) 'RANKL and OPG activity is regulated by injury size in networks of osteocyte-like cells'. Bone, 48 :182-188 [DOI] [Details] |
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| (2011) | 'Temporal and Spatial Changes in Cartilage-Matrix-Specific Gene Expression in Mesenchymal Stem Cells in Response to Dynamic Compression'
Haugh, MG;Meyer, EG;Thorpe, SD;Vinardell, T;Duffy, GP;Kelly, DJ (2011) 'Temporal and Spatial Changes in Cartilage-Matrix-Specific Gene Expression in Mesenchymal Stem Cells in Response to Dynamic Compression'. Tissue Engineering Part A, 17 :3085-3093 [DOI] [Details] |
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| (2011) | 'TOWARDS IN VITRO VASCULARISATION OF COLLAGEN-GAG SCAFFOLDS'
Duffy, GP;McFadden, TM;Byrne, EM;Gill, SL;Farrell, E;O'Brien, FJ (2011) 'TOWARDS IN VITRO VASCULARISATION OF COLLAGEN-GAG SCAFFOLDS'. European Cells & Materials, 21 :15-30 [Details] |
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| (2010) | 'Mesenchymal Stem Cells Overexpressing Ephrin-B2 Rapidly Adopt an Early Endothelial Phenotype with Simultaneous Reduction of Osteogenic Potential'
Duffy, GP;D'Arcy, S;Ahsan, T;Nerem, RM;O'Brien, T;Barry, F (2010) 'Mesenchymal Stem Cells Overexpressing Ephrin-B2 Rapidly Adopt an Early Endothelial Phenotype with Simultaneous Reduction of Osteogenic Potential'. Tissue Engineering Part A, 16 :2755-2768 [DOI] [Details] |
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| (2010) | 'The healing of bony defects by cell-free collagen-based scaffolds compared to stem cell-seeded tissue engineered constructs'
Lyons, FG;Al-Munajjed, AA;Kieran, SM;Toner, ME;Murphy, CM;Duffy, GP;O'Brien, FJ (2010) 'The healing of bony defects by cell-free collagen-based scaffolds compared to stem cell-seeded tissue engineered constructs'. Biomaterials, 31 :9232-9243 [DOI] [Details] |
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| (2009) | 'Bone Marrow-Derived Mesenchymal Stem Cells Promote Angiogenic Processes in a Time- and Dose-Dependent Manner In Vitro'
Duffy, GP;Ahsan, T;O'Brien, T;Barry, F;Nerem, RM (2009) 'Bone Marrow-Derived Mesenchymal Stem Cells Promote Angiogenic Processes in a Time- and Dose-Dependent Manner In Vitro'. Tissue Engineering Part A, 15 :2459-2470 [DOI] [Details] |
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| (2006) | 'Gene-eluting stents: Comparison of adenoviral and adeno-associated viral gene delivery to the blood vessel wall in vivo'
Sharif, F;Hynes, SO;McMahon, J;Cooney, R;Conroy, S;Dockery, P;Duffy, G;Daly, K;Crowley, J;Bartlett, JS;O'Brien, T (2006) 'Gene-eluting stents: Comparison of adenoviral and adeno-associated viral gene delivery to the blood vessel wall in vivo'. Human Gene Therapy, 17 :741-750 [Details] |
Editorial
| Year | Publication | |
|---|---|---|
| (2017) | Tissue Engineered Solutions for Intracardiac Septal Defects: A Large Step Forward in an Unmet Clinical Need.
Hameed, A;Duffy, GP;Hasan, B;Fatimi, SH (2017) Tissue Engineered Solutions for Intracardiac Septal Defects: A Large Step Forward in an Unmet Clinical Need. PHILADELPHIA: Editorial [DOI] [Details] |
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| (2015) | Form and function in regenerative medicine: introduction.
O'Brien, FJ;Duffy, GP (2015) Form and function in regenerative medicine: introduction. HOBOKEN: Editorial [DOI] [Details] |
Reviews
| Year | Publication | |
|---|---|---|
| (2016) | Nanomedicines for advanced cancer treatments: Transitioning towards responsive systems.
van Elk, M;Murphy, BP;Eufrasio-da-Silva, T;O'Reilly, DP;Vermonden, T;Hennink, WE;Duffy, GP;Ruiz-Hernandez, E (2016) Nanomedicines for advanced cancer treatments: Transitioning towards responsive systems. AMSTERDAM: Reviews [DOI] [Details] |
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| (2015) | Drug and cell delivery for cardiac regeneration.
Hastings, CL;Roche, ET;Ruiz-Hernandez, E;Schenke-Layland, K;Walsh, CJ;Duffy, GP (2015) Drug and cell delivery for cardiac regeneration. AMSTERDAM: Reviews [DOI] [Details] |
Patents
| Patent Number | Title | Granted | |
|---|---|---|---|
| US8,617,883 B2 | Stem Cell Source for Promoting Neovascularisation | 31-DEC-13 |
