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Medicine

Dr Daniel Patrick O'Toole

BSc, PhD

Biography

Education
Undergraduate: The National University of Ireland, Galway Date: September 1991 to June 1996
Postgraduate: The University of Dublin, Trinity College Date: October 1996 to December 2000

Employment history
Hospital Technician: St. Patrick's Hospital Dublin Date: January 2001 to March 2001
Research Fellow: University College Dublin, Department Of Pharmacology Date: May 2001 to December 2005
SFI Industry Fellow: National University Of Ireland, Galway, Discipline Of Medicine and Orbsen Therapeutics Inc Date: January 2014 to December 2014
SFI TIDA Fellow: National University Of Ireland, Galway, Discipline Of Medicine Date: January 2015 to December 2015
Honorary Senior Research Lecturer: appointed January 2015
Senior Researcher: National University Of Ireland, Galway, Discipline Of Medicine Date: January 2016 to present

Peer Reviewed Journals

	Year	Publication
	(2018)	'A qualitative synthesis of gastro-oesophageal reflux in bronchiectasis: Current understanding and future risk' McDonnell MJ, O'Toole D, Ward C, Pearson JP, Lord JL, De Soyza A, Loebinger M, Chalmers JD, Laffey JG, Rutherford RM. (2018) 'A qualitative synthesis of gastro-oesophageal reflux in bronchiectasis: Current understanding and future risk'. Respiratory Medicine, [Details]
	(2018)	'Human Mesenchymal Stem Cell Secretome from Bone Marrow or Adipose-Derived Tissue Sources for Treatment of Hypoxia-Induced Pulmonary Epithelial Injury' Shologu N, Scully M, Laffey JG, O'Toole D. (2018) 'Human Mesenchymal Stem Cell Secretome from Bone Marrow or Adipose-Derived Tissue Sources for Treatment of Hypoxia-Induced Pulmonary Epithelial Injury'. International Journal Of Molecular Sciences, [Details]
	(2012)	'Mesenchymal Stem Cells enhance recovery and repair following Ventilation Induced Lung Injury in the Rat' Curley G, Hayes M, Ansari B, Shaw G, Ryan A, Barry F, O’Brien T, O’Toole D, Laffey JG (2012) 'Mesenchymal Stem Cells enhance recovery and repair following Ventilation Induced Lung Injury in the Rat'. Thorax, [Details]
	(2014)	'Aerosol-mediated delivery of AAV2/6-IκBα attenuates lipopolysaccharide-induced acute lung injury in rats' MacLoughlin R, Higgins BD, Devaney J, O'Toole d, Laffey DG, O'Brien T. (2014) 'Aerosol-mediated delivery of AAV2/6-IκBα attenuates lipopolysaccharide-induced acute lung injury in rats'. Human Gene Therapy, [Details]
	(2017)	'Cryopreserved, Xeno-Free Human Umbilical Cord Mesenchymal Stromal Cells Reduce Lung Injury Severity and Bacterial Burden in Rodent Escherichia coli-Induced Acute Respiratory Distress Syndrome' Curley, G. F.,Jerkic, M.,Dixon, S.,Hogan, G.,Masterson, C.,O'Toole, D.,Devaney, J.,Laffey, J. G. (2017) 'Cryopreserved, Xeno-Free Human Umbilical Cord Mesenchymal Stromal Cells Reduce Lung Injury Severity and Bacterial Burden in Rodent Escherichia coli-Induced Acute Respiratory Distress Syndrome'. Crit Care Med, 45 (22) [Details]
	(2016)	'Hypercapnic acidosis attenuates pulmonary epithelial stretch-induced injury via inhibition of the canonical NF-kappaB pathway' Horie, S.,Ansari, B.,Masterson, C.,Devaney, J.,Scully, M.,O'Toole, D.,Laffey, J. G. (2016) 'Hypercapnic acidosis attenuates pulmonary epithelial stretch-induced injury via inhibition of the canonical NF-kappaB pathway'. Intensive Care Med Exp, 4 (11) [Details]
	(2015)	'Mesenchymal stromal cells are more effective than the MSC secretome in diminishing injury and enhancing recovery following ventilator-induced lung injury' Hayes, M.,Curley, G. F.,Masterson, C.,Devaney, J.,O'Toole, D.,Laffey, J. G. (2015) 'Mesenchymal stromal cells are more effective than the MSC secretome in diminishing injury and enhancing recovery following ventilator-induced lung injury'. Intensive Care Med Exp, 3 (11) [Details]
	(2015)	'Sepsis protects the myocardium and other organs from subsequent ischaemic/reperfusion injury via a MAPK-dependent mechanism' Walshe, C. M.,Laffey, J. G.,Kevin, L.,O'Toole, D. (2015) 'Sepsis protects the myocardium and other organs from subsequent ischaemic/reperfusion injury via a MAPK-dependent mechanism'. Intensive Care Med Exp, 3 (11) [Details]
	(2018)	'Syndecan-2-positive, Bone Marrow-derived Human Mesenchymal Stromal Cells Attenuate Bacterial-induced Acute Lung Injury and Enhance Resolution of Ventilator-induced Lung Injury in Rats' Masterson, C,Devaney, J,Horie, S,O'Flynn, L,Deedigan, L,Elliman, S,Barry, F,O'Brien, T,O'Toole, D,Laffey, JG (2018) 'Syndecan-2-positive, Bone Marrow-derived Human Mesenchymal Stromal Cells Attenuate Bacterial-induced Acute Lung Injury and Enhance Resolution of Ventilator-induced Lung Injury in Rats'. Anesthesiology, 129 :502-516 [DOI] [Details]
	(2016)	'Effects and Mechanisms by Which Hypercapnic Acidosis Inhibits Sepsis-Induced Canonical Nuclear Factor-kappa B Signaling in the Lung' Masterson, C,O'Toole, D,Leo, A,McHale, P,Horie, S,Devaney, J,Laffey, JG (2016) 'Effects and Mechanisms by Which Hypercapnic Acidosis Inhibits Sepsis-Induced Canonical Nuclear Factor-kappa B Signaling in the Lung'. Critical Care Medicine, 44 :207-217 [DOI] [Details]
	(2017)	'Interaction between subclinical doses of the Parkinson's disease associated gene, alpha-synuclein, and the pesticide, rotenone, precipitates motor dysfunction and nigrostriatal neurodegeneration in rats' Naughton, C,O'Toole, D,Kirik, D,Dowd, E (2017) 'Interaction between subclinical doses of the Parkinson's disease associated gene, alpha-synuclein, and the pesticide, rotenone, precipitates motor dysfunction and nigrostriatal neurodegeneration in rats'. Behavioural Brain Research, 316 :160-168 [DOI] [Details]
	(2013)	'Mesenchymal stem cell survival in the infarcted heart is enhanced by lentivirus vector-mediated heat shock protein 27 expression' McGinley, L. M.,McMahon, J.,Stocca, A.,Duffy, A.,Flynn, A.,O'Toole, D.,O'Brien, T. (2013) 'Mesenchymal stem cell survival in the infarcted heart is enhanced by lentivirus vector-mediated heat shock protein 27 expression'. Hum Gene Ther, 24 (1010):840-51 [Details]
	(2011)	'Lentiviral vector mediated modification of mesenchymal stem cells & enhanced survival in an in vitro model of ischaemia' McGinley, L.,McMahon, J.,Strappe, P.,Barry, F.,Murphy, M.,O'Toole, D.,O'Brien, T. (2011) 'Lentiviral vector mediated modification of mesenchymal stem cells & enhanced survival in an in vitro model of ischaemia'. Stem Cell Res Ther, 2 (22) [Details]