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About University of Galway
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Accessibility & LanguageMedicine
Dr Brian McDonagh
BSc., MSc., PhD
Contact Details
Lecturer Above The Bar
Physiology
Human Biology Building 3031
University of Galway
Galway
E: brian.mcdonagh@universityofgalway.ie
Physiology
Human Biology Building 3031
University of Galway
Galway
E: brian.mcdonagh@universityofgalway.ie
Biography
Research Interests
Research Projects
| Project | Start Date | End Date | |
|---|---|---|---|
| Constitutively active unfolded protein response in breast Cancer cells protects against ROS induced mitochondrial dysfunction | 01-OCT-19 | 30-SEP-21 | |
| Royal Embassy of Saudia Arabia Scholarship - Turki Sitr M Aljuiad | 01-SEP-19 | 31-AUG-20 | |
| REACTIVE OXYGEN SPECIES AND RESPIRATORY MUSCLE DYSFUNCTION IN HEART FAILURE | 01-JUL-17 | 31-DEC-18 |
Peer Reviewed Journals
| Year | Publication | |
|---|---|---|
| (2024) | 'Peroxiredoxin 2 regulates DAF-16/FOXO mediated mitochondrial remodelling in response to exercise that is disrupted in ageing'
Xia, Qin,Li, Penglin,Casas-Martinez, José C.,Miranda-Vizuete, Antonio,McDermott, Emma,Dockery, Peter,Goljanek-Whysall, Katarzyna,McDonagh, Brian (2024) 'Peroxiredoxin 2 regulates DAF-16/FOXO mediated mitochondrial remodelling in response to exercise that is disrupted in ageing'. Molecular Metabolism, 88 [Details] |
|
| (2024) | 'Redox regulation of UPR signalling and mitochondrial ER contact sites'
Casas-Martinez, Jose C.,Samali, Afshin,McDonagh, Brian (2024) 'Redox regulation of UPR signalling and mitochondrial ER contact sites'. Cellular And Molecular Life Sciences, 81 (1) [Details] |
|
| (2023) | 'Peroxiredoxin 2 is required for the redox mediated adaptation to exercise'
Qin Xia and Jose C. Casas-Martinez and Eduardo Zarzuela and Javier Muñoz and Antonio Miranda-Vizuete and Katarzyna Goljanek-Whysall and Brian McDonagh (2023) 'Peroxiredoxin 2 is required for the redox mediated adaptation to exercise'. Redox Biology, 60 [DOI] [Details] |
|
| (2023) | 'Regulation of metabolism, stress response, and sod1 activity by cytosolic thioredoxins in yeast depends on growth phase'
Picazo, Cecilia,Padilla, C. Alicia,McDonagh, Brian,Matallana, Emilia,Bárcena, José A.,Aranda, AgustÃn (2023) 'Regulation of metabolism, stress response, and sod1 activity by cytosolic thioredoxins in yeast depends on growth phase'. Advances in Redox Research, 9 [Details] |
|
| (2023) | 'The role of microRNAs in muscle wasting and recovery during critical illness: a systematic review'
Borja-Gonzalez, Maria,Coyne, Sarah,Fagan, Sarah,Casas-Martinez, Jose C.,Sannicandro, Anthony J.,McNicholas, Bairbre,O'Connell, Kevin,Laffey, John G.,O'Caoimh, Rónán,McDonagh, Brian,Goljanek-Whysall, Katarzyna (2023) 'The role of microRNAs in muscle wasting and recovery during critical illness: a systematic review'. JCSM Rapid Communications, 6 (2):68-80 [Details] |
|
| (2023) | 'Extracellular Vesicles, Cell-Penetrating Peptides and miRNAs as Future Novel Therapeutic Interventions for Parkinson’s and Alzheimer’s Disease'
Keighron, Cameron Noah and Avazzadeh, Sahar and Goljanek-Whysall, Katarzyna and McDonagh, Brian and Howard, Linda and Ritter, Thomas and Quinlan, Leo R. (2023) 'Extracellular Vesicles, Cell-Penetrating Peptides and miRNAs as Future Novel Therapeutic Interventions for Parkinson’s and Alzheimer’s Disease'. Biomedicines, 11 (3) [DOI] [Details] |
|
| (2022) | 'MicroRNAs as the Sentinels of Redox and Hypertrophic Signalling'
Kolodziej, Filip and McDonagh, Brian and Burns, Nicole and Goljanek-Whysall, Katarzyna (2022) 'MicroRNAs as the Sentinels of Redox and Hypertrophic Signalling'. International Journal of Molecular Sciences, 23 (23) [DOI] [Details] |
|
| (2022) | 'Evidence of impaired mitochondrial cellular bioenergetics in ocular fibroblasts derived from glaucoma patients'
Neeru A. Vallabh and Jane Armstrong and Gabriela Czanner and Brian McDonagh and Anshoo Choudhary and David N. Criddle and Colin E. Willoughby (2022) 'Evidence of impaired mitochondrial cellular bioenergetics in ocular fibroblasts derived from glaucoma patients'. Free Radical Biology and Medicine, 189 :102-110 [DOI] [Details] |
|
| (2021) | 'Exercise stress leads to an acute loss of mitochondrial proteins and disruption of redox control in skeletal muscle of older subjects: An underlying decrease in resilience with aging?'
Jamie N. Pugh and Clare Stretton and Brian McDonagh and Philip Brownridge and Anne McArdle and Malcolm J. Jackson and Graeme L. Close (2021) 'Exercise stress leads to an acute loss of mitochondrial proteins and disruption of redox control in skeletal muscle of older subjects: An underlying decrease in resilience with aging?'. Free Radical Biology and Medicine, 177 :88-99 [DOI] [Details] |
|
| (2021) | 'miR-24 and its target gene Prdx6 regulate viability and senescence of myogenic progenitors during aging'
Soriano-Arroquia, Ana and Gostage, John and Xia, Qin and Bardell, David and McCormick, Rachel and McCloskey, Eugene and Bellantuono, Ilaria and Clegg, Peter and McDonagh, Brian and Goljanek-Whysall, Katarzyna (2021) 'miR-24 and its target gene Prdx6 regulate viability and senescence of myogenic progenitors during aging'. Aging Cell, 20 (10) [DOI] [Details] |
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| (2020) | 'Diaphragm weakness and proteomics (global and redox) modifications in heart failure with reduced ejection fraction in rats'
Kelley RC;McDonagh B;Brumback B;Walter GA;Vohra R;Ferreira LF; (2020) 'Diaphragm weakness and proteomics (global and redox) modifications in heart failure with reduced ejection fraction in rats'. Journal Of Molecular And Cellular Cardiology, 139 [DOI] [Details] |
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| (2020) | 'miR-181a regulates p62/SQSTM1, parkin, and protein DJ-1 promoting mitochondrial dynamics in skeletal muscle aging'
Goljanek-Whysall, K;Soriano-Arroquia, A;McCormick, R;Chinda, C;McDonagh, B (2020) 'miR-181a regulates p62/SQSTM1, parkin, and protein DJ-1 promoting mitochondrial dynamics in skeletal muscle aging'. Aging Cell, [DOI] [Details] |
|
| (2020) | 'Aging Science Talks: The role of miR-181a in age-related loss of muscle mass and function in Translational Medicine Aging'
Borja-Gonzalez M, Casas-Martinez JC, McDonagh B, Goljanek-Whysall K (2020) 'Aging Science Talks: The role of miR-181a in age-related loss of muscle mass and function in Translational Medicine Aging'. Translational Medicine At Unisa, [DOI] [Details] |
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| (2020) | 'MicroRNAs as potential therapeutic targets for muscle wasting during cancer cachexia'
Sannicandro AJ, McDonagh B, Goljanek-Whysall K (2020) 'MicroRNAs as potential therapeutic targets for muscle wasting during cancer cachexia'. Current Opinion In Clinical Nutrition And Metabolic Care, [DOI] [Details] |
|
| (2020) | '2-Cys Peroxiredoxin oxidation in response to Hydrogen Peroxide and contractile activity in skeletal muscle: A novel insight into exercise-induced redox signalling?'
Stretton C;Pugh JN;McDonagh B;McArdle A;Close GL;Jackson MJ; (2020) '2-Cys Peroxiredoxin oxidation in response to Hydrogen Peroxide and contractile activity in skeletal muscle: A novel insight into exercise-induced redox signalling?'. Free Radical Biology And Medicine, [DOI] [Details] |
|
| (2020) | 'Multiomics analysis of the mdx/mTR mouse model of Duchenne muscular dystrophy'
Van Pelt, DW;Kharaz, YA;Sarver, DC;Eckhardt, LR;Dzierzawski, JT;Disser, NP;Piacentini, AN;Comerford, E;McDonagh, B;Mendias, CL (2020) 'Multiomics analysis of the mdx/mTR mouse model of Duchenne muscular dystrophy'. Connective Tissue Research, [DOI] [Details] |
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| (2020) | 'Inflamma-miR-21 Negatively Regulates Myogenesis during Ageing'
Borja-Gonzalez M;Casas-Martinez JC;McDonagh B;Goljanek-Whysall K; (2020) 'Inflamma-miR-21 Negatively Regulates Myogenesis during Ageing'. Antioxidants (Basel, Switzerland), 9 (4) [DOI] [Details] |
|
| (2020) | 'The redox environment and mitochondrial dysfunction in age-related skeletal muscle atrophy'
Shally, A;McDonagh, B (2020) 'The redox environment and mitochondrial dysfunction in age-related skeletal muscle atrophy'. Biogerontology, [DOI] [Details] |
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| (2019) | 'The clinical potential of thiol redox proteomics'
Sheehan, D;McDonagh, B (2019) 'The clinical potential of thiol redox proteomics'. Expert Review Of Proteomics, [DOI] [Details] |
|
| (2019) | 'Reduced mitochondrial lipid oxidation leads to fat accumulation in myosteatosis'
Gumucio JP;Qasawa AH;Ferrara PJ;Malik AN;Funai K;McDonagh B;Mendias CL; (2019) 'Reduced mitochondrial lipid oxidation leads to fat accumulation in myosteatosis'. Faseb Journal, [DOI] [Details] |
|
| (2019) | 'Translational regulation contributes to the secretory response of chondrocytic cells following exposure to Interleukin-1ß'
McDermott BT;Peffers MJ;McDonagh B;Tew SR; (2019) 'Translational regulation contributes to the secretory response of chondrocytic cells following exposure to Interleukin-1ß'. Journal Of Biological Chemistry, [DOI] [Details] |
|
| (2019) | 'Peroxiredoxin 6 Down-Regulation Induces Metabolic Remodeling and Cell Cycle Arrest in HepG2 Cells'
María José LG;Rosa María TV;Beatriz CH;Daniel LR;José P;Brian M;Raquel RA;José Antonio B;Alicia PC; (2019) 'Peroxiredoxin 6 Down-Regulation Induces Metabolic Remodeling and Cell Cycle Arrest in HepG2 Cells'. Antioxidants (Basel, Switzerland), 8 (11) [DOI] [Details] |
|
| (2019) | 'Thioredoxin and glutaredoxin regulate metabolism through different multiplex thiol switches'
Lopez-Grueso, MJ,Gonzalez-Ojeda, R,Requejo-Aguilar, R,McDonagh, B,Fuentes-Almagro, CA,Muntane, J,Barcena, JA,Padilla, CA (2019) 'Thioredoxin and glutaredoxin regulate metabolism through different multiplex thiol switches'. Redox Biology, 21 [DOI] [Details] |
|
| (2019) | 'Proteomic strategies to unravel age-related redox signalling defects in skeletal muscle'
Cobley, JN;Sakellariou, GK;Husi, H;McDonagh, B (2019) 'Proteomic strategies to unravel age-related redox signalling defects in skeletal muscle'. Free Radical Biology & Medicine, :24-32 [DOI] [Details] |
|
| (2019) | 'Saccharomyces cerevisiae Cytosolic Thioredoxins Control Glycolysis, Lipid Metabolism, and Protein Biosynthesis under Wine-Making Conditions'
Picazo, C;McDonagh, B;Peinado, J;Barcena, JA;Matallana, E;Aranda, A (2019) 'Saccharomyces cerevisiae Cytosolic Thioredoxins Control Glycolysis, Lipid Metabolism, and Protein Biosynthesis under Wine-Making Conditions'. Applied And Environmental Microbiology, 85 [DOI] [Details] |
|
| (2018) | 'Redox Homeostasis in Age-Related Muscle Atrophy'
Sakellariou, GK;McDonagh, B (2018) 'Redox Homeostasis in Age-Related Muscle Atrophy'. Inflammation And Cancer, 1088 :281-306 [DOI] [Details] |
|
| (2018) | 'Redox responses are preserved across muscle fibres with differential susceptibility to aging'
Smith, NT,Soriano-Arroquia, A,Goljanek-Whysall, K,Jackson, MJ,McDonagh, B (2018) 'Redox responses are preserved across muscle fibres with differential susceptibility to aging'. Journal Of Proteomics, 177 :112-123 [DOI] [Details] |
|
| (2018) | 'Comparison of Whole Body SOD1 Knockout with Muscle-Specific SOD1 Knockout Mice Reveals a Role for Nerve Redox Signaling in Regulation of Degenerative Pathways in Skeletal Muscle'
Sakellariou, GK,McDonagh, B,Porter, H,Giakoumaki, II,Earl, KE,Nye, GA,Vasilaki, A,Brooks, SV,Richardson, A,Van Remmen, H,McArdle, A,Jackson, MJ (2018) 'Comparison of Whole Body SOD1 Knockout with Muscle-Specific SOD1 Knockout Mice Reveals a Role for Nerve Redox Signaling in Regulation of Degenerative Pathways in Skeletal Muscle'. Antioxidants & Redox Signaling, 28 :275-295 [DOI] [Details] |
|
| (2018) | 'Advanced aging causes diaphragm functional abnormalities, global proteome remodeling, and loss of mitochondrial cysteine redox flexibility in mice'
Kelley, RC,McDonagh, B,Ferreira, LF (2018) 'Advanced aging causes diaphragm functional abnormalities, global proteome remodeling, and loss of mitochondrial cysteine redox flexibility in mice'. Experimental Gerontology, 103 :69-79 [DOI] [Details] |
|
| (2017) | 'Redox homeostasis and age-related deficits in neuromuscular integrity and function'
Sakellariou, GK;Lightfoot, AP;Earl, KE;Stofanko, M;McDonagh, B (2017) 'Redox homeostasis and age-related deficits in neuromuscular integrity and function'. Journal of Cachexia, Sarcopenia and Muscle, 8 :881-906 [DOI] [Details] |
|
| (2017) | 'Detection of ROS Induced Proteomic Signatures by Mass Spectrometry'
McDonagh, B (2017) 'Detection of ROS Induced Proteomic Signatures by Mass Spectrometry'. Frontiers in physiology, 8 [DOI] [ARAN Link] [Details] |
|
| (2016) | 'Ageing in relation to skeletal muscle dysfunction: redox homoeostasis to regulation of gene expression'
Goljanek-Whysall, K;Iwanejko, LA;Vasilaki, A;Pekovic-Vaughan, V;McDonagh, B (2016) 'Ageing in relation to skeletal muscle dysfunction: redox homoeostasis to regulation of gene expression'. Mammalian Genome, 27 :341-357 [DOI] [Details] |
|
| (2016) | 'Ageing-induced changes in the redox status of peripheral motor nerves imply an effect on redox signalling rather than oxidative damage'
McDonagh, B;Scullion, SM;Vasilaki, A;Pollock, N;McArdle, A;Jackson, MJ (2016) 'Ageing-induced changes in the redox status of peripheral motor nerves imply an effect on redox signalling rather than oxidative damage'. Free Radical Biology & Medicine, 94 :27-35 [DOI] [Details] |
|
| (2016) | 'Ageing in relation to skeletal muscle dysfunction: redox homoeostasis to regulation of gene expression'
Goljanek-Whysall, K;Iwanejko, LA;Vasilaki, A;Pekovic-Vaughan, V;McDonagh, B (2016) 'Ageing in relation to skeletal muscle dysfunction: redox homoeostasis to regulation of gene expression'. Mammalian Genome, :341-357 [DOI] [Details] |
|
| (2016) | 'Glutathione Is the Resolving Thiol for Thioredoxin Peroxidase Activity of 1-Cys Peroxiredoxin Without Being Consumed During the Catalytic Cycle'
Pedrajas, JR;McDonagh, B;Hernandez-Torres, F;Miranda-Vizuete, A;Gonzalez-Ojeda, R;Martinez-Galisteo, E;Padilla, CA;Barcena, JA (2016) 'Glutathione Is the Resolving Thiol for Thioredoxin Peroxidase Activity of 1-Cys Peroxiredoxin Without Being Consumed During the Catalytic Cycle'. Antioxidants & Redox Signaling, 24 :115-128 [DOI] [Details] |
|
| (2015) | 'Redox proteomic analysis of the gastrocnemius muscle from adult and old mice'
McDonagh, B; Sakellariou, GK; Smith, NT; Brownridge, P; Jackson MJ (2015) 'Redox proteomic analysis of the gastrocnemius muscle from adult and old mice'. Data In Brief, 4 :344-348 [DOI] [Details] |
|
| (2014) | 'Application of redox proteomics to skeletal muscle aging and exercise'
McDonagh, B;Sakellariou, GK;Jackson, MJ (2014) 'Application of redox proteomics to skeletal muscle aging and exercise'. Biochemical Society Transactions, 42 :965-970 [DOI] [Details] |
|
| (2014) | 'Differential Cysteine Labeling and Global Label-Free Proteomics Reveals an Altered Metabolic State in Skeletal Muscle Aging'
McDonagh, B;Sakellariou, GK;Smith, NT;Brownridge, P;Jackson, MJ (2014) 'Differential Cysteine Labeling and Global Label-Free Proteomics Reveals an Altered Metabolic State in Skeletal Muscle Aging'. Journal Of Proteome Research, 13 :5008-5021 [DOI] [Details] |
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| (2014) | 'Closing a small gap in our understanding of excitation-contraction coupling: JSR90/JFP90 is Junctophilin 1'
English, KK; Sorrentino, V; Aiello, AC; Kiely, M; Kiely, PA; McDonagh, B; Mackrill JJ (2014) 'Closing a small gap in our understanding of excitation-contraction coupling: JSR90/JFP90 is Junctophilin 1'. Clinical calcium, 1 (1):1-6 [Details] |
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| (2013) | 'Thiol Redox Sensitivity of Two Key Enzymes of Heme Biosynthesis and Pentose Phosphate Pathways: Uroporphyrinogen Decarboxylase and Transketolase'
McDonagh, B;Pedrajas, JR;Padilla, CA;Barcena, JA (2013) 'Thiol Redox Sensitivity of Two Key Enzymes of Heme Biosynthesis and Pentose Phosphate Pathways: Uroporphyrinogen Decarboxylase and Transketolase'. Oxidative Medicine And Cellular Longevity, [DOI] [Details] |
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| (2013) | 'Sunlight exposure increases the phenolic content in postharvested white grapes. An evaluation of their antioxidant activity in Saccharomyces cerevisiae'
Peinado, J;de Lerma, NL;Peralbo-Molina, A;Priego-Capote, F;de Castro, C;McDonagh, B (2013) 'Sunlight exposure increases the phenolic content in postharvested white grapes. An evaluation of their antioxidant activity in Saccharomyces cerevisiae'. Journal Of Functional Foods, 5 :1566-1575 [DOI] [Details] |
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| (2012) | 'Redox Proteomics in Study of Kidney-Associated Hypertension: New Insights to Old Diseases'
Sheehan, D,Rainville, LC,Tyther, R,McDonagh, B (2012) 'Redox Proteomics in Study of Kidney-Associated Hypertension: New Insights to Old Diseases'. Antioxidants & Redox Signaling, 17 :1560-1570 [DOI] [Details] |
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| (2012) | 'Application of iTRAQ Reagents to Relatively Quantify the Reversible Redox State of Cysteine Residues'
McDonagh, B; Martínez-Acedo, P: Vázquez, J; Padilla, CA; Sheehan, D; Bárcena, JA (2012) 'Application of iTRAQ Reagents to Relatively Quantify the Reversible Redox State of Cysteine Residues'. Journal Of Proteomics, 514847 (2012):54187-54196 [DOI] [Details] |
|
| (2012) | 'Nitrogen starvation induces extensive changes in the redox proteome of Prochlorococcus sp strain SS120'
McDonagh, B;Dominguez-Martin, MA;Gomez-Baena, G;Lopez-Lozano, A;Diez, J;Barcena, JA;Fernandez, JMG (2012) 'Nitrogen starvation induces extensive changes in the redox proteome of Prochlorococcus sp strain SS120'. Environmental Microbiology Reports, 4 :257-267 [DOI] [Details] |
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| (2011) | 'Biosynthetic and Iron Metabolism Is Regulated by Thiol Proteome Changes Dependent on Glutaredoxin-2 and Mitochondrial Peroxiredoxin-1 in Saccharomyces cerevisiae'
McDonagh, B;Padilla, CA;Pedrajas, JR;Barcena, JA (2011) 'Biosynthetic and Iron Metabolism Is Regulated by Thiol Proteome Changes Dependent on Glutaredoxin-2 and Mitochondrial Peroxiredoxin-1 in Saccharomyces cerevisiae'. Journal Of Biological Chemistry, 286 :15565-15576 [DOI] [Details] |
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| (2011) | 'PROTEOMICS IN INVESTIGATION OF PROTEIN NITRATION IN KIDNEY DISEASE: TECHNICAL CHALLENGES AND PERSPECTIVES FROM THE SPONTANEOUSLY HYPERTENSIVE RAT'
Tyther, R,McDonagh, B,Sheehan, D (2011) 'PROTEOMICS IN INVESTIGATION OF PROTEIN NITRATION IN KIDNEY DISEASE: TECHNICAL CHALLENGES AND PERSPECTIVES FROM THE SPONTANEOUSLY HYPERTENSIVE RAT'. Mass Spectrometry Reviews, 30 :121-141 [DOI] [Details] |
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| (2011) | 'Thiol redox proteomics identifies differential targets of cytosolic and mitochondrial glutaredoxin-2 isoforms in Saccharomyces cerevisiae. Reversible S-glutathionylation of DHBP synthase (RIB3)'
McDonagh, B;Requejo, R;Fuentes-Almagro, CA;Ogueta, S;Barcena, JA;Padilla, CA (2011) 'Thiol redox proteomics identifies differential targets of cytosolic and mitochondrial glutaredoxin-2 isoforms in Saccharomyces cerevisiae. Reversible S-glutathionylation of DHBP synthase (RIB3)'. Journal Of Proteomics, 74 :2487-2497 [DOI] [Details] |
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| (2010) | 'Structure and function of yeast glutaredoxin 2 depend on postranslational processing and are related to subcellular distribution'
Porras, P; McDonagh, B; Pedrajas, JR; Bárcena, JA; Padilla CA (2010) 'Structure and function of yeast glutaredoxin 2 depend on postranslational processing and are related to subcellular distribution'. Biochimica Et Biophysica Acta, 1804 (4):839-845 [DOI] [Details] |
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| (2010) | 'Redox proteomics'
Sheehan, D,McDonagh, B,Barcena, JA (2010) 'Redox proteomics'. Expert Review Of Proteomics, 7 :1-4 [DOI] [Details] |
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| (2010) | 'Glutaredoxin Participates in the Reduction of Peroxides by the Mitochondrial 1-CYS Peroxiredoxin in Saccharomyces cerevisiae'
Pedrajas, JR;Padilla, CA;McDonagh, B;Barcena, JA (2010) 'Glutaredoxin Participates in the Reduction of Peroxides by the Mitochondrial 1-CYS Peroxiredoxin in Saccharomyces cerevisiae'. Antioxidants & Redox Signaling, 13 :249-258 [DOI] [Details] |
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| (2010) | 'Proteomic Profiling of Perturbed Protein Sulfenation in Renal Medulla of the Spontaneously Hypertensive Rat'
Tyther, R;Ahmeda, A;Johns, E;McDonagh, B;Sheehan, D (2010) 'Proteomic Profiling of Perturbed Protein Sulfenation in Renal Medulla of the Spontaneously Hypertensive Rat'. Journal Of Proteome Research, 9 :2678-2687 [DOI] [Details] |
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| (2010) | 'Shotgun redox proteomics in sub-proteomes trapped on functionalised beads Identification of proteins targeted by oxidative stress'
Hu, WT,Tedesco, S,McDonagh, B,Sheehan, D (2010) 'Shotgun redox proteomics in sub-proteomes trapped on functionalised beads Identification of proteins targeted by oxidative stress'. Marine Environmental Research, 69 :25-27 [DOI] [Details] |
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| (2010) | 'Selection of thiol- and disulfide-containing proteins of Escherichia coli on activated thiol-Sepharose'
Hu, WT,Tedesco, S,McDonagh, B,Barcena, JA,Keane, C,Sheehan, D (2010) 'Selection of thiol- and disulfide-containing proteins of Escherichia coli on activated thiol-Sepharose'. Analytical Biochemistry, 398 :245-253 [DOI] [Details] |
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| (2010) | 'Ubiquitination and carbonylation of proteins in the clam Ruditapes decussatus, exposed to nonylphenol using redox proteomics'
Chora, S,McDonagh, B,Sheehan, D,Starita-Geribaldi, M,Romeo, M,Bebianno, MJ (2010) 'Ubiquitination and carbonylation of proteins in the clam Ruditapes decussatus, exposed to nonylphenol using redox proteomics'. Chemosphere, 81 :1212-1217 [DOI] [Details] |
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| (2010) | 'Ubiquitination and carbonylation of proteins in the clam Ruditapes decussatus, exposed to nonylphenol using redox proteomics'
Chora, S;McDonagh, B;Sheehan, D;Starita-Geribaldi, M;Romeo, M;Bebianno, MJ (2010) 'Ubiquitination and carbonylation of proteins in the clam Ruditapes decussatus, exposed to nonylphenol using redox proteomics'. Chemosphere, 81 :1212-1217 [DOI] [Details] |
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| (2009) | 'Shotgun redox proteomics identifies specifically modified cysteines in key metabolic enzymes under oxidative stress in Saccharomyces cerevisiae'
McDonagh, B; Ogueta, S; Lasarte, G; Padilla, CA; Bárcena JA (2009) 'Shotgun redox proteomics identifies specifically modified cysteines in key metabolic enzymes under oxidative stress in Saccharomyces cerevisiae'. Journal Of Proteomics, 72 (4):677-689 [DOI] [Details] |
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| (2008) | 'Ubiquitination and carbonylation as markers of oxidative-stress in Ruditapes decussatus'
Chora, S,McDonagh, B,Sheehan, D,Starita-Geribaldi, M,Romeo, M,Bebianno, MJ (2008) 'Ubiquitination and carbonylation as markers of oxidative-stress in Ruditapes decussatus'. Marine Environmental Research, 66 :95-97 [DOI] [Details] |
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| (2008) | 'Effects of oxidative stress on protein thiols and disulphides in Mytilus edulis revealed by proteomics: Actin and protein disulphide isomerase are redox targets'
McDonagh, B,Sheehan, D (2008) 'Effects of oxidative stress on protein thiols and disulphides in Mytilus edulis revealed by proteomics: Actin and protein disulphide isomerase are redox targets'. Marine Environmental Research, 66 :193-195 [DOI] [Details] |
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| (2008) | 'Oxidative stress and bivalves: a proteomic approach'
McDonagh, B; Sheehan, D (2008) 'Oxidative stress and bivalves: a proteomic approach'. Isj-Invertebrate Survival Journal, 5 :110-123 [Details] |
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| (2007) | 'Effect of oxidative stress on protein thiols in the blue mussel Mytilus edulis: Proteomic identification of target proteins'
McDonagh, B,Sheehan, D (2007) 'Effect of oxidative stress on protein thiols in the blue mussel Mytilus edulis: Proteomic identification of target proteins'. Proteomics, 7 :3395-3403 [DOI] [Details] |
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| (2007) | 'Oxidative stress in response to xenobiotics in the blue mussel Mytilus edulis L.: Evidence for variation along a natural'
Prevodnik, A,Gardestrom, J,Lilja, K,Elfwing, T,McDonagh, B,Petrovic, N,Tedengren, M,Sheehan, D,Bollner, T (2007) 'Oxidative stress in response to xenobiotics in the blue mussel Mytilus edulis L.: Evidence for variation along a natural'. Aquatic Toxicology, 82 :63-71 [DOI] [Details] |
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| (2006) | 'Redox proteomics in the mussel Mytilus edulis'
Sheehan, D,McDonagh, B,Tyther, R (2006) 'Redox proteomics in the mussel Mytilus edulis'. Marine Environmental Research, 62 :157-157 [Details] |
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| (2006) | 'Redox proteomics in the blue mussel Mytilus edulis: Carbonylation is not a pre-requisite for ubiquitination in acute free radical-mediated oxidative stress'
McDonagh, B,Sheehan, D (2006) 'Redox proteomics in the blue mussel Mytilus edulis: Carbonylation is not a pre-requisite for ubiquitination in acute free radical-mediated oxidative stress'. Aquatic Toxicology, 79 :325-333 [DOI] [Details] |
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| (2006) | 'Two-dimensional electrophoresis analysis of glutathione affinity-selected proteins from the clam Tapes semidecussatus: Evidence for tissue-specific expression of redox proteins'
Dowling, V,McDonagh, B,Cotter, EM,O'Brien, N,van Pelt, F,O'Halloran, J,Sheehan, D (2006) 'Two-dimensional electrophoresis analysis of glutathione affinity-selected proteins from the clam Tapes semidecussatus: Evidence for tissue-specific expression of redox proteins'. Comparative Biochemistry And Physiology D-Genomics & Proteomics, 1 :267-272 [DOI] [Details] |
|
| (2006) | 'Redox proteomics in the mussel, Mytilus edulis'
McDonagh, B,Tyther, R,Sheehan, D (2006) 'Redox proteomics in the mussel, Mytilus edulis'. Marine Environmental Research, 62 :101-104 [DOI] [Details] |
|
| (2005) | 'Carbonylation and glutathionylation of proteins in the blue mussel Mytilus edulis detected by proteomic analysis and Western blotting: Actin as a target for oxidative stress'
McDonagh, B,Tyther, R,Sheehan, D (2005) 'Carbonylation and glutathionylation of proteins in the blue mussel Mytilus edulis detected by proteomic analysis and Western blotting: Actin as a target for oxidative stress'. Aquatic Toxicology, 73 :315-326 [DOI] [Details] |
Book Chapters
| Year | Publication | |
|---|---|---|
| (2012) | 'Diagonal Electrophoresis for the Detection of Protein Disulfides'
McDonagh, B (2012) 'Diagonal Electrophoresis for the Detection of Protein Disulfides' In: Methods in Molecular Biology. :309-315 NJ: Springer. [DOI] [Details] |
|
| (2009) | 'Diagonal Electrophoresis for Detection of Protein Disulphide Bridges'
McDonagh, B (2009) 'Diagonal Electrophoresis for Detection of Protein Disulphide Bridges' In: Methods Molecular Biology. :305-310 NJ: Springer. [DOI] [Details] |
|
| (2009) | 'Detection of Ubiquitination in 2DE'
McDonagh, B (2009) 'Detection of Ubiquitination in 2DE' In: Methods Molecular Biology. :377-381 NJ: Springer. [DOI] [Details] |
|
| (2009) | 'Immunoblotting 2DE membranes'
McDonagh, B (2009) 'Immunoblotting 2DE membranes' In: Methods Molecular Biology. :103-109 NA: Springer. [DOI] [Details] |
Published Reports
| Year | Publication | |
|---|---|---|
| (2019) | Thioredoxin and glutaredoxin regulate metabolism through different multiplex thiol switches.
Maria Jose Lopez Grueso; Raúl González Ojeda; Raquel Requejo Aguilar; Brian McDonagh; Carlos A Fuentes; Jordi Muntané Relat; Jose Antonio Barcena Ruiz; Carmen Alicia Padilla Peña (2019) Thioredoxin and glutaredoxin regulate metabolism through different multiplex thiol switches. Elsevier, Redox Biology. 21:101049. [DOI] [Details] |
Editorial
| Year | Publication | |
|---|---|---|
| (2017) | microRNA-SIRT-1 interactions: key regulators of adult skeletal muscle homeostasis?.
McCormick, R,McDonagh, B,Goljanek-Whysall, K (2017) microRNA-SIRT-1 interactions: key regulators of adult skeletal muscle homeostasis?. Editorial [DOI] [Details] |
|
| (2016) | Editorial: Redox Regulation in Skeletal Muscle Aging and Exercise.
McDonagh, B (2016) Editorial: Redox Regulation in Skeletal Muscle Aging and Exercise. LAUSANNE: FRONTIERS MEDIA SA Editorial [DOI] [Details] |
Reviews
| Year | Publication | |
|---|---|---|
| (2020) | MicroRNAs as potential therapeutic targets for muscle wasting during cancer cachexia.
Sannicandro, AJ;McDonagh, B;Goljanek-Whysall, K (2020) MicroRNAs as potential therapeutic targets for muscle wasting during cancer cachexia. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS Reviews [DOI] [Details] |
|
| (2017) | Redox homeostasis and age-related deficits in neuromuscular integrity and function.
Sakellariou, GK;Lightfoot, AP;Earl, KE;Stofanko, M;McDonagh, B (2017) Redox homeostasis and age-related deficits in neuromuscular integrity and function. HOBOKEN: WILEY Reviews [DOI] [Details] |
Committees
| Committee | Function | From / To | |
|---|---|---|---|
| Graduate Research Committee | Member | 01-MAY-17 / |
Professional Associations
| Association | Function | From / To | |
|---|---|---|---|
| Higher Education Academy | Fellow | / | |
| Society for Free Radical Research | Member | / | |
| Biochemistry Society | Member | / |
Current Postgraduate Students (Taught)
| Name | Degree | Primary Supervisor | |
|---|---|---|---|
| Shreya Sali | Msc | Y | |
| Ronald Saraswat | Msc | Y | |
| Mark Toomey | Msc | ||
| Christopher Doyle | Msc | Y | |
| Lyndsey Flanagan | Msc | Y | |
| Tim Doherty | Msc | Y |
Recent Postgraduate Students
| Graduation | Name | Degree | Primary Supervisor | |
|---|---|---|---|---|
| 2018 | Neil T Smith | PhD | Y | |
| 2015 | James King Tours | Y | ||
| 2016 | Abigail Cook | Y |
Modules Taught
| Term/Year | Module Title | Module Code | Subject / Desc | |
|---|---|---|---|---|
| 2018-19 | Research Project | SI435 | ||
| 2018-19 | Pathophysiology | SI432 | ||
| 2018-19 | Science Communication | SI4102 | ||
| 2018-19 | Case Based Physiology | SI4101 | ||
| 2018-19 | Renal Physiology | SI331 | ||
| 2018-19 | Human Body Function | SI317 | ||
| 2018-19 | Ageing and Older People | NU6102 | ||
| 2018-19 | Biological Sciences II | NU249 | ||
| 2018/19 | Muscle and Nerve | SI207 | ||
| 2018-19 | Biological Sciences III | NU306 | ||
| 2018/19 | Biological Sciences I | NU1107 | ||
| 2017-18 | Research Projects | SI435 | ||
| 2018-19 | Advanced Gastrointestinal Physiology | SI438 | ||
| 2018-19 | Laboratory Methods in Physiology | SI329 | ||
| 2018-19 | Cardiovascular Physiology | SI208 | ||
| 2018-19 | Exercise Physiology | ET1500 | ||
| 2017-18 | Human Body Function | SI317 | ||
| 2017-18 | Renal Physiology | SI331 | ||
| 2017-18 | Biological Sciences | NU115 | ||
| 2017-18 | Muscle and Nerve | SI 207 | ||
| 2017-18 | Pathophysiology | SI432 | ||
| 2017-18 | Respiratory | SI212 | ||
| 2017-18 | Case Based Physiology | SI4101 | ||
| 2017-18 | Advanced Gastrointestinal Physiology | SI438 | ||
| 2017-18 | Laboratory Methods in Physiology | SI329 |
External Collaborators
| Name | Organisation / Institute | Country | Description of Collaboration | |
|---|---|---|---|---|
| Prof Malcolm Jackson | Institute of Ageing and Chronic Disease | UNITED KINGDOM | ||
| Leonardo Ferreira | University of Florida | U.S.A. | ||
| Jose Antonio Barcena | University of Cordoba | SPAIN | ||
| Christopher Mendias | University of Michigan | U.S.A. | ||
| Katarzyna Whysall | University of Liverpool | UNITED KINGDOM | ||
| Simon Tew | University of Liverpool | UNITED KINGDOM | ||
| Robert Cooper | University of Liverpool | UNITED KINGDOM | ||
| Colin Willoughby | University of Liverpool | UNITED KINGDOM |
