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Medicine

Dr Aideen Ryan

B.Sc., Ph.D.

Contact Details

Senior Lecturer
School of Medicine
University of Galway
E: aideen.ryan@universityofgalway.ie
 
researcher
 

Biography

Dr. Aideen Ryan is an Associate Professor in the School of Medicine, University of Galway and is a member of the Lambe Institute for Translational Research.
Dr Ryan has a BSc. in Biochemistry and Microbiology from NUI Galway and a PhD in Medicine from University College Cork. Her PhD research focused on the role of Fas Ligand and immune suppression and cancer, specifically in the area of colon cancer. Dr. Ryan started her post-doctoral career in Prof. Laurence Egan's lab at NUIG, where she studied the role of NF-kappaB in colon cancer metastasis using molecular and cellular technologies, as well as other disease models. Following this, Dr. Ryan moved to the Immunology Group within the Regenerative Medicine Institute (REMEDI).
Dr. Ryan's work has led to a number of significant publications which were the foundation to the acquisition of several recent prestigious independent grants, postdoctoral fellowships and international awards including Deans Awards for Rseearch and Graduate Studeis (2021), SFI Frontiers for the Future Award (2020), Young Person of the Year Award (2019), Presidents Award for Research Excellence (2019), Research Paper of the Year Award (2019), Future Leader Award Cancer Immunotherapy SITC (2019) among others.

Dr. Ryan has multiple industry collaborations in the area of immune-oncology and stromal cell immunology. Over the course of Dr. Ryan's research career to date, there have been several interesting outcomes, most notably research publications describing novel discoveries in Cancer Immunology Research, Cell reports, Gut, Cancer Research, Oncogene, Molecular Therapy and Cell Cycle, which rank as top journals in the field of Cancer Biology and Stromal cell immunology.

Dr. Ryans current research interests include understanding mechanisms of immune modulation of mesenchymal stromal cells, colon tumor cell and stromal cell interactions in the colon cancer microenvironment, as well as understanding mechanisms of immune evasion in colon cancer with particular focus on the influence of tumor cell NF-kappaB activity and macrophage/stromal cell interactions on the microenvironment.

Research Projects

  Project Start Date End Date
RESTRAIN - Investigation of tumour stromal interactions in metastatic colon cancer for the identification of novel immuno-therapeutic targets 01-DEC-16 30-NOV-21
JANSSEN RESEARCH & DEVELOPMENT 20-DEC-15 31-DEC-22
NOS2&COX2 activation of TLR4 & EGFR signalling causes poor outcome in oestrogen receptor-negative breast cancer via pro-survival signals and immune polarisation 01-MAY-14 01-MAY-17
Cellular interactions in tumour microenvironment during inflammation associated 01-OCT-13 01-OCT-17
Molecular Regulation of the tumour Microenvironment in Colon Cancer Metastasis 11-MAR-19 18-JUL-19
Bristol-Myers Squibb Co.- Low dose cyclophosphamide, elotuzumab and nivolumab: a novel immunotherapeutic strategy for multiple myeloma 13-FEB-18 13-FEB-23
Molecular Regulation of the tumour microenvironment in colon cancer metastasis 01-JAN-13 30-APR-16
EI H2020 PROPOSAL PREP SUPPORT - INVESTIGATION OF COLON CANCER INDUCED STROMAL CELL IMMUNOLOGICAL AND METABOLIC PHENOTYPES AND SUBSEQUENT EFFECTS ON THE ANTI-TUMOUR IMMUNE RESPONSE 31-JUL-17 30-APR-19

Contract Researchers

  Researcher Name Project Role Funding Body
Dr Oliver Treacy Investigation of tumour stromal interactions for the identification of novel immunotherapeutic targets Senior Post Doctoral Researcher
Dr Serika Naicker Investigating novel methods for potentiation of monoclonal antibody therapies in cancer Leading researcher on an industry funded project investigating methods to potentiate the effect of monoclonal antibody therapies for cancer
Dr. Kevin Lynch Bristol Myers Squibb Post Doctoral Researcher

Peer Reviewed Journals

  Year Publication
(2025) 'Identification of Disease-stage Therapeutic Responses of Mesenchymal Stromal Cells Retrieved from Murine Osteoarthritic Joints'
Ivanovska A, Mancuso P, Burke A, Hennesy C, Raman S, Dooley C, McLoughlin S, Shaw G, Mukeria E, Reilly J, O'Brien A, Ritter T, Ryan AE, Kamath R, Levesque MC, Van Riet D, English K, Hawthorne I, Johnstone B, Morris DW, Barry F, Murphy MJ (2025) 'Identification of Disease-stage Therapeutic Responses of Mesenchymal Stromal Cells Retrieved from Murine Osteoarthritic Joints'. Frontiers In Cell And Developmental Biology, [Details]
(2024) 'Auranofin loaded silk fibroin nanoparticles for colorectal cancer treatment'
Pérez-Lloret M, Reidy E, Lozano-Pérez AA, Marchal JA, Lens PNL, Ryan AE, Erxleben A (2024) 'Auranofin loaded silk fibroin nanoparticles for colorectal cancer treatment'. Drug Delivery And Translational Research, [DOI] [Details]
(2024) 'Tumor-associated mesenchymal stromal cells modulate macrophage phagocytosis in stromal-rich colorectal cancer via PD-1 signaling'
Leonard NA, Corry SM, Reidy E, Egan H, O'Malley G, Thompson K, McDermott E, O'Neill A, Zakaria N, Egan LJ, Ritter T, Loessner D, Redmond K, Sheehan M, Canney A, Hogan AM, Hynes SO, Treacy O, Dunne PD, Ryan AE (2024) 'Tumor-associated mesenchymal stromal cells modulate macrophage phagocytosis in stromal-rich colorectal cancer via PD-1 signaling'. iScience, 27 (9) [DOI] [Details]
(2024) 'Hypersialylation and multiple myeloma'
ODwyer MD, Glavey S, McAvera R, Natoni A, Ryan AE (2024) 'Hypersialylation and multiple myeloma'. Frontiers in Hematology, 14 (1) [DOI] [Details]
(2024) 'Dual gene set enrichment analysis (dualGSEA); an R function that enables more robust biological discovery and pre-clinical model alignment from transcriptomics data'
Bull C, Byrne RM, Fisher NC, Corry SM, Amirkhah R, Edwards J, Hillson LVS, Lawler M, Ryan AE, Lamrock F, Dunne PD, Malla SB (2024) 'Dual gene set enrichment analysis (dualGSEA); an R function that enables more robust biological discovery and pre-clinical model alignment from transcriptomics data'. Scientific Reports, 14 (1) [DOI] [Details]
(2024) 'Immunomodulatory potential of cytokine-licensed human bone marrow-derived mesenchymal stromal cells correlates with potency marker expression profile'
Wang J, Zhou Y, Donohoe E, Canning A, Moosavizadeh S, Ryan AE, Ritter T (2024) 'Immunomodulatory potential of cytokine-licensed human bone marrow-derived mesenchymal stromal cells correlates with potency marker expression profile'. Stem Cells (Dayton, Ohio), 42 (12):1040-1054 [DOI] [Details]
(2023) 'Targeting stromal cell sialylation reverses T cell-mediated immunosuppression in the tumor microenvironment'
Egan, H; Treacy, O; Lynch, K; Leonard, NA; O'Malley, G; Reidy, E; O'Neill, A; Corry, SM; De Veirman, K; Vanderkerken, K; Egan, LJ; Ritter, T; Hogan, AM; Redmond, K; Peng, L; Che, J; Gatlin, W; Jayaraman, P; Sheehan, M; Canney, A; Hynes, SO; Kerr, EM; Dunne, PD; O'Dwyer, ME; Ryan, AE. (2023) 'Targeting stromal cell sialylation reverses T cell-mediated immunosuppression in the tumor microenvironment'. Cell Reports, 45 (5) [DOI] [Details]
(2023) 'Immunomodulatory function of licensed human bone marrow mesenchymal stromal cell-derived apoptotic bodies'
Wang J, Donohue E, Canning A, Moosavizadeh S, Buckley F, Brennan MA, Ryan AE, Ritter T (2023) 'Immunomodulatory function of licensed human bone marrow mesenchymal stromal cell-derived apoptotic bodies'. International Immunology, [DOI] [Details]
(2022) 'CyBorD-DARA in Newly Diagnosed Transplant-Eligible Multiple Myeloma: Results from the 16-BCNI-001/CTRIAL-IE 16-02 Study Show High Rates of MRD Negativity at End of Treatment'
Swan D, Henderson R, McEllistrim C, Naicker SD, Quinn J, Cahill MR, Mykytiv V, Lenihan E, Mulvaney E, Nolan M, Parker I, Natoni A, Lynch K, Ryan AE, Szegezdi E, Krawczyk J, Murphy P, O'Dwyer M (2022) 'CyBorD-DARA in Newly Diagnosed Transplant-Eligible Multiple Myeloma: Results from the 16-BCNI-001/CTRIAL-IE 16-02 Study Show High Rates of MRD Negativity at End of Treatment'. Clinical Lymphoma Myeloma & Leukemia, 22 (11):847-852 [DOI] [Details]
(2022) 'Activation of innate-adaptive immune machinery by poly(I:C) exposes a therapeutic vulnerability to prevent relapse in stroma-rich colon cancer'
Corry SM, McCorry AM, Lannagan TR, Leonard NA, Fisher NC, Byrne RM, Tsantoulis P, CORT and ACRCelerate consortia, McDade S, Longley, DB, Loughrey MB, Coleman HG, Kerr, EM, Tejpar S, Maughan T, Leedham SJ, Small DM, Ryan AE, Sansom OJ, Lawler M, Dunne PD (2022) 'Activation of innate-adaptive immune machinery by poly(I:C) exposes a therapeutic vulnerability to prevent relapse in stroma-rich colon cancer'. Gut, 71 (12):2502-2517 [DOI] [Details]
(2021) 'Cyclophosphamide alters the tumor cell secretome to potentiate the anti-myeloma activity of daratumumab through augmentation of macrophage-mediated antibody dependent cellular phagocytosis'
Naicker SD, Feerick CL, Lynch K, Swan D, McEllistrim C, Henderson R, Leonard NA, Treacy O, Natoni A, Rigalou A, Cabral J, Chiu C, Sasser K, Ritter T, O'Dwyer M, Ryan AE (2021) 'Cyclophosphamide alters the tumor cell secretome to potentiate the anti-myeloma activity of daratumumab through augmentation of macrophage-mediated antibody dependent cellular phagocytosis'. Oncoimmunology, 10 (1) [DOI] [Details]
(2021) 'Considerations for treatment duration in responders to immune checkpoint inhibitors'
Marron TU;Ryan AE;Reddy SM;Kaczanowska S;Younis RH;Thakkar D;Zhang J;Bartkowiak T;Howard R;Anderson KG;Olson D;Naqash AR;Patel RB;Sachdev E;Rodriguez-Ruiz ME;Sheffer M;Church S;Fuhrman C;Overacre-Delgoffe A;Nguyen R;Florou V;Thaxton JE;Aggen DH;Guerriero JL; (2021) 'Considerations for treatment duration in responders to immune checkpoint inhibitors'. Journal For Immunotherapy Of Cancer, 9 (3) [DOI] [Details]
(2021) 'A 3D View of Colorectal Cancer Models in Predicting Therapeutic Responses and Resistance'
Reidy E;Leonard NA;Treacy O;Ryan AE; (2021) 'A 3D View of Colorectal Cancer Models in Predicting Therapeutic Responses and Resistance'. Cancers (Basel), 13 (2) [DOI] [Details]
(2021) 'Nitric Oxide Modulates Processes in the Tumour Immune Microenvironment'
McGinty, CL, Palmieri EM, Somanduram V, Bhattacharryya D, Ridnour LA, Cheng RYS, Ryan AE, Glynn SA, Thomas DD, Mirnda KM, Andreson SK, Lockett, SJ, McVicar DW, Wink DA (2021) 'Nitric Oxide Modulates Processes in the Tumour Immune Microenvironment'. International Journal of Molecular Sciences, 22 (13) [DOI] [Details]
(2021) 'Subconjunctival administration of low-dose murine allogeneic mesenchymal stromal cells promotes corneal allograft survival in mice'
Treacy O;Lynch K;Murphy N;Chen X;Donohoe E;Canning A;Lohan P;Shaw G;Fahy G;Ryan AE;Ritter T; (2021) 'Subconjunctival administration of low-dose murine allogeneic mesenchymal stromal cells promotes corneal allograft survival in mice'. Stem Cell Research & Therapy, 12 (1) [DOI] [ARAN Link] [Details]
(2021) 'Stromal Cells Promote Matrix Deposition, Remodelling and an Immunosuppressive Tumour Microenvironment in a 3D Model of Colon Cancer'
Leonard NA, Reidy E, Thompson K, McDermott E, Peerani E, Tomas Bort E, Balkwill FR, Loessner D, Ryan AE (2021) 'Stromal Cells Promote Matrix Deposition, Remodelling and an Immunosuppressive Tumour Microenvironment in a 3D Model of Colon Cancer'. Cancers (Basel), 13 (23) [DOI] [Details]
(2020) 'TGF-ß1-Licensed Murine MSCs Show Superior Therapeutic Efficacy in Modulating Corneal Allograft Immune Rejection In Vivo'
Lynch K;Treacy O;Chen X;Murphy N;Lohan P;Islam MN;Donohoe E;Griffin MD;Watson L;McLoughlin S;O'Malley G;Ryan AE;Ritter T; (2020) 'TGF-ß1-Licensed Murine MSCs Show Superior Therapeutic Efficacy in Modulating Corneal Allograft Immune Rejection In Vivo'. Molecular Therapy : The Journal Of The American Society Of Gene Therapy, 28 (9):1-21 [DOI] [ARAN Link] [Details]
(2020) 'Administration of Human Non-Diabetic Mesenchymal Stromal Cells to a Murine Model of Diabetic Fracture Repair: A Pilot Study'
Watson, L.; Chen, X.Z.; Ryan, A.E.; Fleming, Á.; Carbin, A.; O'Flynn, L.; Loftus, P.G.; Horan, E.; Connolly, D.; McDonnell, P.; McNamara, L.M.; O'Brien, T.; Coleman, C.M. (2020) 'Administration of Human Non-Diabetic Mesenchymal Stromal Cells to a Murine Model of Diabetic Fracture Repair: A Pilot Study'. Cells, 9 (6):1-20 [DOI] [Details]
(2020) 'The pseudo-caspase FLIP(L) regulates cell fate following p53 activation'
Lees A, McIntyre AJ, Crawford NT, Falcone F, McCann C, Holohan C, Quinn GP, Roberts JZ, Sessler T, Gallagher PF, Gregg GMA, McAllister K, McLaughlin KM, Allen WL, Egan LJ, Ryan AE, Labonte-Wilson MJ, Dunne PD, Wappett M, Coyle VM, Johnston PG, Kerr EM, Longley DB, McDade SS (2020) 'The pseudo-caspase FLIP(L) regulates cell fate following p53 activation'. Proc Natl Acad Sci U S A, 117 (30):17808-17819 [DOI] [Details]
(2020) 'Beyond DNA Damage: Exploring the Immunomodulatory Effects of Cyclophosphamide in Multiple Myeloma'
Swan D;Gurney M;Krawczyk J;Ryan AE;O'Dwyer M (2020) 'Beyond DNA Damage: Exploring the Immunomodulatory Effects of Cyclophosphamide in Multiple Myeloma'. Hemasphere, 4 (2) [DOI] [Details]
(2019) 'TNF-a/IL-1ß-licensed mesenchymal stromal cells promote corneal allograft survival via myeloid cell-mediated induction of Foxp3+ regulatory T cells in the lung'
Murphy N;Treacy O;Lynch K;Morcos M;Lohan P;Howard L;Fahy G;Griffin MD;Ryan AE;Ritter T (2019) 'TNF-a/IL-1ß-licensed mesenchymal stromal cells promote corneal allograft survival via myeloid cell-mediated induction of Foxp3+ regulatory T cells in the lung'. Faseb Journal, 33 (8):9404-9421 [DOI] [Details]
(2019) 'CyBorD-DARA is potent initial induction for MM and enhances ADCP: initial results of the 16-BCNI-001/CTRIAL-IE 16-02 study'
O'Dwyer, M;Henderson, R;Naicker, SD;Cahill, MR;Murphy, P;Mykytiv, V;Quinn, J;McEllistrim, C;Krawczyk, J;Walsh, J;Lenihan, E;Kenny, T;Hernando, A;Hirakata, G;Parker, I;Kinsella, E;Gannon, G;Natoni, A;Lynch, K;Ryan, AE (2019) 'CyBorD-DARA is potent initial induction for MM and enhances ADCP: initial results of the 16-BCNI-001/CTRIAL-IE 16-02 study'. Blood Advances, 3 (12):1815-1825 [DOI] [Details]
(2018) 'Stromal Cell PD-L1 Inhibits CD8(+) T-cell Antitumor Immune Responses and Promotes Colon Cancer'
O'Malley, G,Treacy, O,Lynch, K,Naicker, SD,Leonard, NA,Lohan, P,Dunne, PD,Ritter, T,Egan, LJ,Ryan, AE (2018) 'Stromal Cell PD-L1 Inhibits CD8(+) T-cell Antitumor Immune Responses and Promotes Colon Cancer'. Cancer Immunology Research, 6 :1426-1441 [DOI] [ARAN Link] [Details]
(2018) 'Extracellular vesicles as modulators of wound healing'
Cabral, J., Ryan, A.E., Griffin, M.D., Ritter, T. (2018) 'Extracellular vesicles as modulators of wound healing'. Advanced Drug Delivery Reviews, 129 :394-406 [DOI] [ARAN Link] [Details]
(2018) 'Third-Party Allogeneic Mesenchymal Stromal Cells Prevent Rejection in a Pre-sensitized High-Risk Model of Corneal Transplantation'
Lohan, P,Murphy, N,Treacy, O,Lynch, K,Morcos, M,Chen, BL,Ryan, AE,Griffin, MD,Ritter, T (2018) 'Third-Party Allogeneic Mesenchymal Stromal Cells Prevent Rejection in a Pre-sensitized High-Risk Model of Corneal Transplantation'. Frontiers In Immunology, 9 :1-14 [DOI] [ARAN Link] [Details]
(2018) 'Interspecies Incompatibilities Limit the Immunomodulatory Effect of Human Mesenchymal Stromal Cells in the Rat'
Lohan, P;Treacy, O;Morcos, M;Donohoe, E;O'donoghue, Y;Ryan, AE;Elliman, SJ;Ritter, T;Griffin, MD (2018) 'Interspecies Incompatibilities Limit the Immunomodulatory Effect of Human Mesenchymal Stromal Cells in the Rat'. Stem Cells (Dayton, Ohio), 36 :1210-1215 [DOI] [Details]
(2018) 'Secreted factors from metastatic prostate cancer cells stimulate mesenchymal stem cell transition to a pro-tumourigenic 'activated' state that enhances prostate cancer cell migration'
Ridge, SM;Bhattacharyya, D;Dervan, E;Naicker, SD;Burke, AJ;Murphy, JM;O'leary, K;Greene, J;Ryan, AE;Sullivan, FJ;Glynn, SA (2018) 'Secreted factors from metastatic prostate cancer cells stimulate mesenchymal stem cell transition to a pro-tumourigenic 'activated' state that enhances prostate cancer cell migration'. International Journal Of Cancer, 142 (10):2056-2067 [DOI] [Details]
(2017) 'Impact of inducible nitric oxide synthase (iNOS) expression on triple negative breast cancer outcome and activation of EGFR and ERK signaling pathways'
Garrido, P,Shalaby, A,Walsh, EM,Keane, N,Webber, M,Keane, MM,Sullivan, FJ,Kerin, MJ,Callagy, G,Ryan, AE,Glynn, SA (2017) 'Impact of inducible nitric oxide synthase (iNOS) expression on triple negative breast cancer outcome and activation of EGFR and ERK signaling pathways'. Oncotarget, 8 (46):80568-80588 [DOI] [Details]
(2017) 'Coexpression of NOS2 and COX2 accelerates tumor growth and reduces survival in estrogen receptor-negative breast cancer'
Basudhar D, Glynn SA, Greer M, Somasundaram V, No JH, Scheiblin DA, Garrido P, Heinz WF, Ryan AE, Weiss JM, Cheng RYS, Ridnour LA, Lockett SJ, McVicar DW, Ambs S, Wink DA. (2017) 'Coexpression of NOS2 and COX2 accelerates tumor growth and reduces survival in estrogen receptor-negative breast cancer'. Proceedings Of The National Academy Of Sciences Of The United States Of America, 114 (49):13030-13035 [DOI] [Details]
(2017) 'Anti-Donor Immune Responses Elicited by Allogeneic Mesenchymal Stem Cells and Their Extracellular Vesicles: Are We Still Learning?'
Lohan, P;Treacy, O;Griffin, MD;Ritter, T;Ryan, AE (2017) 'Anti-Donor Immune Responses Elicited by Allogeneic Mesenchymal Stem Cells and Their Extracellular Vesicles: Are We Still Learning?'. Frontiers In Immunology, 8 :1-8 [DOI] [ARAN Link] [Details]
(2017) 'Regulating Immunogenicity and Tolerogenicity of Bone Marrow-Derived Dendritic Cells through Modulation of Cell Surface Glycosylation by Dexamethasone Treatment'
Lynch, K,Treacy, O,Gerlach, JQ,Annuk, H,Lohan, P,Cabral, J,Joshi, L,Ryan, AE,Ritter, T (2017) 'Regulating Immunogenicity and Tolerogenicity of Bone Marrow-Derived Dendritic Cells through Modulation of Cell Surface Glycosylation by Dexamethasone Treatment'. Frontiers In Immunology, 8 :1-16 [DOI] [ARAN Link] [Details]
(2016) 'vIL-10-overexpressing human MSCs modulate naïve and activated T lymphocytes following induction of collagenase-induced osteoarthritis'
Farrell, E,Fahy, N,Ryan, AE,Flatharta, CO,O'Flynn, L,Ritter, T,Murphy, JM (2016) 'vIL-10-overexpressing human MSCs modulate naïve and activated T lymphocytes following induction of collagenase-induced osteoarthritis'. Stem Cell Research & Therapy, 7 (1) [DOI] [Details]
(2016) 'Donor-derived equine mesenchymal stem cells suppress proliferation of mismatched lymphocytes'
Ranera, B,Antczak, D,Miller, D,Doroshenkova, T,Ryan, A,McIlwraith, CW,Barry, F (2016) 'Donor-derived equine mesenchymal stem cells suppress proliferation of mismatched lymphocytes'. Equine Veterinary Journal, 48 (2):253-260 [DOI] [Details]
(2016) 'Decoy receptors block TRAIL sensitivity at a supracellular level: the role of stromal cells in controlling tumour TRAIL sensitivity'
O'Leary, L,van der Sloot, AM,Reis, CR,Deegan, S,Ryan, AE,Dhami, SPS,Murillo, LS,Cool, RH,de Sampaio, PC,Thompson, K,Murphy, G,Quax, WJ,Serrano, L,Samali, A,Szegezdi, E (2016) 'Decoy receptors block TRAIL sensitivity at a supracellular level: the role of stromal cells in controlling tumour TRAIL sensitivity'. Oncogene, 35 :1261-1270 [DOI] [Details]
(2016) 'Culture expanded primary chondrocytes have potent immunomodulatory properties and do not induce an allogeneic immune response'
Lohan, P;Treacy, O;Lynch, K;Barry, F;Murphy, M;Griffin, MD;Ritter, T;Ryan, AE (2016) 'Culture expanded primary chondrocytes have potent immunomodulatory properties and do not induce an allogeneic immune response'. Osteoarthritis And Cartilage, 24 :521-533 [DOI] [Details]
(2016) 'Mesenchymal stromal cells (MSCs) and colorectal cancer: a troublesome twosome for the anti-tumour immune response?'
O'Malley G;Heijltjes M;Houston AM;Rani S;Ritter T;Egan LJ;Ryan AE; (2016) 'Mesenchymal stromal cells (MSCs) and colorectal cancer: a troublesome twosome for the anti-tumour immune response?'. Oncotarget, 7 (37):60752-60774 [DOI] [Details]
(2015) 'Pullulan: a new cytoadhesive for cell-mediated cartilage repair'
Bulman, SE,Coleman, CM,Murphy, JM,Medcalf, N,Ryan, AE,Barry, F (2015) 'Pullulan: a new cytoadhesive for cell-mediated cartilage repair'. Stem Cell Research & Therapy, 6 (1):1-12 [DOI] [Details]
(2015) 'Targeting colon cancer cell NF-kappa B promotes an anti-tumour M1-like macrophage phenotype and inhibits peritoneal metastasis'
Ryan, AE,Colleran, A,O'Gorman, A,O'Flynn, L,Pindjacova, J,Lohan, P,O'Malley, G,Nosov, M,Mureau, C,Egan, LJ (2015) 'Targeting colon cancer cell NF-kappa B promotes an anti-tumour M1-like macrophage phenotype and inhibits peritoneal metastasis'. Oncogene, 34 :1563-1574 [DOI] [Details]
(2015) 'Mesenchymal Stem Cell-derived Extracellular Vesicles: Toward Cell-free Therapeutic Applications'
Rani, S,Ryan, AE,Griffin, MD,Ritter, T (2015) 'Mesenchymal Stem Cell-derived Extracellular Vesicles: Toward Cell-free Therapeutic Applications'. Molecular Therapy, 23 (5):812-823 [DOI] [Details]
(2015) 'Immune Modulation to Improve Tissue Engineering Outcomes for Cartilage Repair in the Osteoarthritic Joint'
Fahy, N,Farrell, E,Ritter, T,Ryan, AE,Murphy, JM (2015) 'Immune Modulation to Improve Tissue Engineering Outcomes for Cartilage Repair in the Osteoarthritic Joint'. Tissue Engineering Part B-Reviews, 21 (1):55-66 [DOI] [Details]
(2014) 'Chondrogenic Differentiation Increases Antidonor Immune Response to Allogeneic Mesenchymal Stem Cell Transplantation'
Ryan, AE;Lohan, P;O'Flynn, L;Treacy, O;Chen, X;Coleman, C;Shaw, G;Murphy, M;Barry, F;Griffin, MD;Ritter, T (2014) 'Chondrogenic Differentiation Increases Antidonor Immune Response to Allogeneic Mesenchymal Stem Cell Transplantation'. Molecular Therapy : The Journal Of The American Society Of Gene Therapy, 22 (3):655-667 [DOI] [Details]
(2014) 'Mesenchymal Stem Cell Therapy Promotes Corneal Allograft Survival in Rats by Local and Systemic Immunomodulation'
Treacy O, O'Flynn L, Ryan AE, Morcos M, Lohan P, Schu S, Wilk M, Fahy G, Griffin MD, Nosov M, Ritter T (2014) 'Mesenchymal Stem Cell Therapy Promotes Corneal Allograft Survival in Rats by Local and Systemic Immunomodulation'. American Journal Of Transplantation, 14 (9):2023-2036 [DOI] [Details]
(2014) 'Changes in immunological profile of allogeneic mesenchymal stem cells after differentiation: should we be concerned?'
Lohan, P.; Coleman, C.M.; Murphy, M.; Griffin, M.D.; Ritter, T.; Ryan, A.E. (2014) 'Changes in immunological profile of allogeneic mesenchymal stem cells after differentiation: should we be concerned?'. Current Stem Cell Research & Therapy, :99-110 [DOI] [Details]
(2013) 'Donor bone marrow-derived dendritic cells prolong corneal allograft survival and promote an intragraft immunoregulatory milieu'
O'Flynn L, Treacy O, Ryan AE, Morcos M, Cregg M, Gerlach J, Joshi L, Nosov M, Ritter T (2013) 'Donor bone marrow-derived dendritic cells prolong corneal allograft survival and promote an intragraft immunoregulatory milieu'. Molecular Therapy, 21 (11):2102-2112 [DOI] [ARAN Link] [Details]
(2013) 'Effects of Intratracheal Mesenchymal Stromal Cell Therapy during Recovery and Resolution after Ventilator-induced Lung Injury'
Curley GF, Ansari B, Hayes M, Devaney J, Masterson C, Ryan A, Barry F, O'Brien T, Toole DO, Laffey JG (2013) 'Effects of Intratracheal Mesenchymal Stromal Cell Therapy during Recovery and Resolution after Ventilator-induced Lung Injury'. Anesthesiology, 118 (4):924-932 [DOI] [Details]
(2013) 'Targeting the EP1 receptor reduces Fas ligand expression and increases the antitumor immune response in an in vivo model of colon cancer'
O'Callaghan, G,Ryan, A,Neary, P,O'Mahony, C,Shanahan, F,Houston, A (2013) 'Targeting the EP1 receptor reduces Fas ligand expression and increases the antitumor immune response in an in vivo model of colon cancer'. International Journal Of Cancer, 133 :825-834 [DOI] [Details]
(2013) 'Anti-donor immune responses elicited by allogeneic mesenchymal stem cells: what have we learned so far?'
Griffin, MD,Ryan, AE,Alagesan, S,Lohan, P,Treacy, O,Ritter, T (2013) 'Anti-donor immune responses elicited by allogeneic mesenchymal stem cells: what have we learned so far?'. Immunology And Cell Biology, 91 :40-51 [DOI] [Details]
(2012) 'Mesenchymal stem cells enhance recovery and repair following ventilator-induced lung injury in the rat'
Curley, GF;Hayes, M;Ansari, B;Shaw, G;Ryan, A;Barry, F;O'Brien, T;O'Toole, D;Laffey, JG (2012) 'Mesenchymal stem cells enhance recovery and repair following ventilator-induced lung injury in the rat'. Thorax, 67 :496-501 [DOI] [Details]
(2012) 'Adenoviral Transduction of Mesenchymal Stem Cells: In Vitro Responses and In Vivo Immune Responses after Cell Transplantation'
Treacy, O,Ryan, AE,Heinzl, T,O'Flynn, L,Cregg, M,Wilk, M,Odoardi, F,Lohan, P,O'Brien, T,Nosov, M,Ritter, T (2012) 'Adenoviral Transduction of Mesenchymal Stem Cells: In Vitro Responses and In Vivo Immune Responses after Cell Transplantation'. Plos One, 7 (8):1-13 [DOI] [Details]
(2011) 'Autophagosomal I kappa B alpha Degradation Plays a Role in the Long Term Control of Tumor Necrosis Factor-alpha-induced Nuclear Factor-kappa B (NF-kappa B) Activity'
Colleran, A,Ryan, A,O'Gorman, A,Mureau, C,Liptrot, C,Dockery, P,Fearnhead, H,Egan, LJ (2011) 'Autophagosomal I kappa B alpha Degradation Plays a Role in the Long Term Control of Tumor Necrosis Factor-alpha-induced Nuclear Factor-kappa B (NF-kappa B) Activity'. Journal Of Biological Chemistry, 286 :22886-22893 [DOI] [Details]
(2010) 'Regulation of NF-kappa B responses by epigenetic suppression of I kappa B alpha expression in HCT116 intestinal epithelial cells'
O'Gorman, A;Colleran, A;Ryan, A;Mann, J;Egan, LJ (2010) 'Regulation of NF-kappa B responses by epigenetic suppression of I kappa B alpha expression in HCT116 intestinal epithelial cells'. American Journal Of Physiology: Gastrointestinal And Liver Physiology, 299 :96-105 [DOI] [Details]
(2008) 'The Fas counterattack is not an active mode of tumor immune evasion in colorectal cancer with high-level microsatellite instability'
Houston, AM,Michael-Robinson, JM,Walsh, MD,Cummings, MC,Ryan, AE,Lincoln, D,Pandeya, N,Jass, JR,Radford-Smith, GL,O'Connell, J (2008) 'The Fas counterattack is not an active mode of tumor immune evasion in colorectal cancer with high-level microsatellite instability'. Human Pathology, 39 :243-250 [DOI] [Details]
(2006) 'Induction of apoptosis in renal cell carcinoma by reactive oxygen species: Involvement of extracellular signal-regulated kinase 1/2, p38 delta/gamma, cyclooxygenase-2 down-regulation, and translocation of apoptosis-inducing factor'
Ambrose, M,Ryan, A,O'Sullivan, GC,Dunne, C,Barry, OP (2006) 'Induction of apoptosis in renal cell carcinoma by reactive oxygen species: Involvement of extracellular signal-regulated kinase 1/2, p38 delta/gamma, cyclooxygenase-2 down-regulation, and translocation of apoptosis-inducing factor'. Molecular Pharmacology, 69 :1879-1890 [DOI] [Details]
(2006) 'Fas ligand expression in human and mouse cancer cell lines ; a caveat on over-reliance on mRNA data'
Ryan AE, Lane S, Shanahan F, O'Connell J, Houston AM (2006) 'Fas ligand expression in human and mouse cancer cell lines ; a caveat on over-reliance on mRNA data'. Carcinogenesis, 5 (1):1-5 [DOI] [Details]
(2006) 'Fas Ligand Promotes Tumor Immune Evasion of Colon Cancer In Vivo'
Ryan, AE,Shanahan, F,O'Connell, J,Houston, AM (2006) 'Fas Ligand Promotes Tumor Immune Evasion of Colon Cancer In Vivo'. Cell Cycle, 5 (3):246-249 [DOI] [Details]
(2005) 'Addressing the Fas counterattack controversy: Blocking Fas ligand expression suppresses tumor immune evasion of colon cancer in vivo'
Ryan, AE,Shanahan, F,O'Connell, J,Houston, AM (2005) 'Addressing the Fas counterattack controversy: Blocking Fas ligand expression suppresses tumor immune evasion of colon cancer in vivo'. Cancer Research, 65 :9817-9823 [DOI] [Details]
(2002) 'Rapid development of a quantitative competitive (qc) RT-PCR assay using a composite primer approach'
O'Connell J, Houston AM, Kelly R, O'Brien D, Ryan AE, Bennett, MW, Nally K (2002) 'Rapid development of a quantitative competitive (qc) RT-PCR assay using a composite primer approach'. Methods in Molecular Biology, 193 :93-102 [DOI] [Details]

Conference Publications

  Year Publication
(2024) Blood
O'Dwyer M, Ryan AE, O'Neill A, Guerin-Charbonnel C, Wuilleme S, Corre J, Loiseau HA, Peng L, Moreau P, Minvielle S (2024) Increased Expression of the Sialyltransferase Gene ST3GAL1 Predicts Lack of Sustained MRD Negativity and Increased Risk of Progression in Newly Diagnosed, Transplant Eligible Multiple Myeloma Patients in the Maintenance/Observation Phase of Cassiopeia Study Blood [DOI] [Details]
(2024) Mesentery Peritoneum 2024
Zakaria N, ONeill A, Egan H, Treacy O, Che J, Peng L, Sheehan M, Canney A, Hynes S, Hogan A, Ryan A (2024) Stromal cell-mediated immunosuppression: sialylated ligands as orchestrators of T cell and natural killer cell suppression in the tumour microenvironment of colorectal cancer Mesentery Peritoneum 2024 [Details]
(2024) Acta Ophthalmol
Canning A, Donohoe E, Wang J, Moosavizadeh S, Treacy O, Ryan A, Ritter T (2024) TNF-a/IL-1B cytokine licensing enhances immunomodulatory potential of allogeneic mesenchymal stromal cells Acta Ophthalmol [DOI] [Details]
(2024) Investigative Ophthalmology & Visual Science
Ritter T, Wang J, Donohoe E,Jammes M, Bach T,Canning,Ryan AE, Moosavizadeh S (2024) Small Extracellular Vesicles Derived From Pre-Activated Mesenchymal Stromal Cells For Treatment Of Ocular Inflammation And Injury Investigative Ophthalmology & Visual Science [Details]
(2024) Mesentery Peritoneum 2024
Gorman E, Walsh A, Treacy O, Hogan A, Ryan A (2024) Feasibility of establishment of a novel public and patient involvement (PPI) panel in multidisciplinary laboratory-based colorectal cancer research Mesentery Peritoneum 2024 [Details]
(2024) European Association for Vision and Eye Research Congress
Moosavizadeh S, Donohoe E, Wang J, Canning A, Jammes M, Bach T, Tabasi A, Robinson T, Moakes R, Ryan A, Grover L (2024) Encapsulation of msc-derived extracellular vesicles in biomaterials for effective drug delivery to the ocular surface European Association for Vision and Eye Research Congress [DOI] [Details]
(2023) Journal for ImmunoTherapy of Cancer
O'Neill A, Egan H, Treacy O, Hogan A, Hynes S, Ryan AE (2023) Targeting stromal cell sialylation to overcome tumour-induced immunosuppressive effects on NK cells in colorectal cancer Journal for ImmunoTherapy of Cancer [DOI] [Details]
(2023) Cytotherapy
Donohoe E, Canning A, Wang J, Moosavizadeh S, Ryan AE, Ritter T (2023) CYTOKINE LICENSING ENHANCES THE IMMUNOMODULATORY CAPACITY AND THERAPEUTIC POTENTIAL OF MESENCHYMAL STROMAL CELL-DERIVED EXTRACELLULAR VESICLES Cytotherapy [Details]
(2023) Journal for ImmunoTherapy of Cancer
Treacy O, Che J, Gatlin W, Cao L, Egan H, O'Neill A, O'Dwyer M, Jayaraman P, Peng L, Ryan AE (2023) Stromal hypersialylation within colorectal tumors contributes to immunosuppression of T cell adaptive immunity in the tumor microenvironment Journal for ImmunoTherapy of Cancer [DOI] [Details]
(2023) Journal for ImmunoTherapy of Cancer
Reidy E, Leonard N, Pandit A, Ryan AE (2023) Developing a 3D multicellular model to investigate stromal and immune interactions in colorectal cancer tumour microenvironment Journal for ImmunoTherapy of Cancer [DOI] [Details]
(2023) Journal for ImmunoTherapy of Cancer
Leonard N, Corry S, Treacy O, Reidy E, Redmond K, Egan H, Sheehan M, Canney A, Hogan A, Loessner D, Egan L, Ryan AE (2023) 967 Inflammatory tumour microenvironment in CRC alters macrophage function through mesenchymal stromal cell PD-1/PD-L1 signalling Journal for ImmunoTherapy of Cancer [DOI] [Details]
(2022) Journal for Immunotherapy of Cancer
Ryan A, Treacy O, Lynch K, De Veirman K, Vanderkerken K, Egan L, Ritter T, Hogan A, Redmond K, Hynes S, Kerr E, O'Dwyer M, Dunne P, Leonard N, Egan H (2022) 1444Targeting sialic acid on stromal cells reverses T cell suppression in the colorectal tumour microenvironment a new tumour stromal cell immune checkpoint Journal for Immunotherapy of Cancer [Details]
(2022) ORPHEUS 2022
Kelly, JP, Finn DP, Ryan AE (2022) Development of a teaching module for PhD Candidates in Pharmacology ORPHEUS 2022 Istanbul, Turkey, , 12-MAY-22 [Details]
(2022) Cytotherapy
Ivanovska A, Mancuso P, Hennessy C, McLoughlin S, Reilly J, Raman S, Dooley C,Ritter T,Ryan AE, Kamath R,Levesque M,van Riet D, Barry F, Murphy M (2022) Transcriptome Profile of retrieved mesenchayml stem/stromal cells in a collagenase induced murine osteoarthritis model Cytotherapy , pp.76-77 [Details]
(2021) Molecular Therapy
Ritter T, Lynch K, Murphy N, Chen XZ, Canning A, Donohoe E, Lohan P, Shaw G, Fahy G, Ryan A, Treacy O (2021) Subconjunctival Administration of Low Dose Murine Allogeneic Mesenchymal Stromal Cells Promotes Corneal Allograft Survival in Mice Molecular Therapy [Details]
(2021) European Journal of Immunology
Leonard NA, Treacy O, Lynch K, O'Malley G, Egan H, Reidy E, Ritter T, Loessner D, Egan LJ, Ryan AE (2021) Stromal cells in the complex colorectal tumour microenvironment modulate the innate immune system in 2D and 3D culture systems European Journal of Immunology [Details]
(2021) European Journal of Immunology
Egan H, Treacy O, Leonard N, Lynch K, Nader A, Hynes S, Sheehan M, Egan LJ, Ritter T, Daly J, Hogan AM, O'Dwyer M, Ryan AE (2021) The T-cells sweet tooth: T-lymphocytes exposed to highly sialylated cancer associated fibroblasts present an exhausted phenotype, which can be reversed through desialylation European Journal of Immunology [Details]
(2021) American Society of Hematology
Swan D, O'Dwyer ME,Cahill M, Krawczyk, Mykytiv JV, Quinn J, Henderson R, McEllistrim C, Hernando A, Parker I, Nolan M, Lenihan E, Szegezdi E,Naicker SD, Lynch K, Natoni A, Ryan AE, Murphy P, (2021) Cybord-Dara in Newly Diagnosed Transplant-Eligible Multiple Myeloma: Follow up Results from the 16-Bcni-001/Ctrial-IE 16-02 Study Show High Rates of MRD Negativity at End of Treatment American Society of Hematology [Details]
(2021) Society for Immunotherapy of Cancer
Treacy O, Egan H, Lynch K, Leonard N, De Veirman K, Vanderkerken K, Egan LJ, Ritter T, Hogan A, Redmond K, Krawczyk J, Hynes S, Kerr, E, Dunne PD, O'Dwyer M, Ryan AE (2021) Stromal cell sialylation suppresses T cells in inflammatory tumour microenvironments: a new tumour stromal cell immune checkpoint? Society for Immunotherapy of Cancer [Details]
(2021) Blood
Feerick CL, Lynch K, Krawczyk J, O'Dwyer M, Ryan A (2021) Low Dose Cyclophosphamide in Combination with Elotuzumab - a Novel Immunotherapeutic Strategy for Multiple Myeloma Blood [Details]
(2020) Cancer Research
McCorry AM, Leonard NA, Jackstadt R, Flanagan DJ, Sansom OJ, Maughan T, Leedham S, Kerr EM, Ryan AE, Lawler M, Dunne PD (2020) Abstract 3867: STAT1-related antigen processing and presentation dictates prognosis in the fibroblast-rich subtype of stage II/III colon cancer Cancer Research [Details]
(2020) Journal for Immunotherapy of Cancer
Egan H, Treacy O, Lynch K, Leonard N, Nader A, Sheehan M, Hynes S, Egan LJ, Ritter T, Daly J, Hogan AM, O'Dwyer M, Ryan AE (2020) SUGAR HIGH: DOES THE SIALIC ACID PROFILE OF CANCER-ASSOCIATED FIBROBLASTS INDUCE A MORE TUMOUR-PERMISSIVE MICROENVIRONMENT Journal for Immunotherapy of Cancer [Details]
(2020) BRITISH JOURNAL OF SURGERY
Samy, A,Treacy, O,Leonard, N,Lynch, K,Hynes, S,Sheehan, M,Egan, L,Hogan, A,Ryan, A (2020) Elucidating the Circulating and Tumour-Specific Immune Populations in a Cohort of Colon Cancer Patients BRITISH JOURNAL OF SURGERY , pp.158-158 [Details]
(2020) Cancer Research
Lees A, McIntyre AJMJ, Crawford NT, Falcone F, McCann C, Quinn GP, Roberts JZ, Sessler T, Gallagher PF, Gregg GM, McAllister K, McLaughlin KM, Allen WL, Holohan C, Egan LJ, Ryan AE, Labonte-Wilson M, Dunne PD, Wappett M, Coye VM, Johnston PG, Kerr EM, Longley DB, McDade SS (2020) FLIP(L) determines colon cancer cell fate following p53 activation Cancer Research [Details]
(2020) Immunotherapy of Cancer
Leonard NA, Treacy O, Egan H, OMalley G, Bort ET, Peerani E, Ritter T, Loessner D, Egan LJ, Ryan AE (2020) THE MESENCHYMAL STROMAL COMPARTMENT IN COLORECTAL CANCER GREATLY ALTERS THE INNATE TUMOUR IMMUNE MICROENVIRONMENT BOTH IN 2D AND 3D CULTURE SYSTEMS Immunotherapy of Cancer [Details]
(2019) CLINICAL LYMPHOMA MYELOMA & LEUKEMIA
Lynch, K,De Veirman, K,Egan, H,Leonard, N,O'Malley, G,Ritter, T,Ryan, A,O'Dwyer, M (2019) Mesenchymal Stromal Cell Sialylation Modulates Antitumor Immune Responses In Multiple Myeloma CLINICAL LYMPHOMA MYELOMA & LEUKEMIA , pp.93-94 [Details]
(2019) Investigative Ophthalmology & Visual Science
Ritter T, Donohoe E, Treacy O, Lynch K, Chen XZ, Fahy G, Ryan A, Murphy N (2019) Subconjunctival injection of low-dose mesenchymal stem cells promotes corneal allograft survival in a mouse cornea transplantation model Investigative Ophthalmology & Visual Science [Details]
(2019) Osteoarthritis and Cartilage
Hennessy C, Mancuso P, Ivanovska A, Burke A, Mukeria E, Ritter T, Barry F, Murphy M, Ryan A (2019) Immunomodulatory abilities of licensed mesenchymal stem cells: a potential therapeutic strategy in osteoarthritis Osteoarthritis and Cartilage [Details]
(2019) JOURNAL FOR IMMUNOTHERAPY OF CANCER
Egan, H,Lynch, K,Leonard, N,Egan, MOL,Ritter, T,Treacy, O,Ryan, A (2019) The role of sialylation in stromal cell mediated immunosuppression in the colorectal tumour microenvironment JOURNAL FOR IMMUNOTHERAPY OF CANCER [Details]
(2018) HemaSphere
Lynch k, De Veirman K, O'Malley G, Vanderkerken K, Ryan A, O'Dwyer M, Ritter T, (2018) MESENCHYMAL STROMAL CELL SIALYATION ENHANCES IMMUNE SUPPRESSION: IMPLICATIONS IN MULTIPLE MYELOMA HemaSphere [Details]
(2018) Cancer Research
Basudhar D, Glynn S, Greer M, Somasundaram V, No JH, Scheiblin DA, Garrido P, Heinz WF, Ryan AE, Weiss JM, Cheng RY, Ridnour LA, Lockett SJ, McVicar DW, Ambs, S, Wink DA (2018) Role of NOS2-COX2 crosstalk in tumor microenvironment of estrogen receptor-negative breast cancer and its therapeutic implications Cancer Research [Details]
(2018) OSTEOARTHRITIS AND CARTILAGE
Burke, AJ,Mancuso, P,Dooley, C,Ritter, T,Barry, F,Murphy, MJ,Ryan, AE (2018) ESTABLISHMENT OF THE IN VIVO IMMUNOLOGICAL PROFILE IN COLLAGENASE INDUCED OSTEOARTHRITIS OSTEOARTHRITIS AND CARTILAGE , pp.127-127 [Details]
(2018) OSTEOARTHRITIS AND CARTILAGE
Mancuso, P,Burke, AJ,Raman, S,Ryan, AE,Ritter, T,Barry, F,Murphy, MJ (2018) MESENCHYMAL STEM CELL THERAPY FOR OSTEOARTHRITIS: HOW APOPTOTIC CELLS MODULATE INFLAMMATION OSTEOARTHRITIS AND CARTILAGE , pp.297-297 [Details]
(2017) Blood
Lynch K, O'Malley G, Ryan A, Ritter T, O'Dwyer M (2017) Mesenchymal Stromal Cell Sialylation Enhances Immune Suppression in Multiple Myeloma Blood [Details]
(2017) Cancer Research
O'Malley G, Lynch K, Naicker S, Lohan P, Rigalou A, Ritter T, Egan LJ, Ryan AE (2017) Inflammatory signalling in the colon tumour microenvironment enhances stromal cell mediated suppression of anti-tumour immune responses Cancer Research [Details]
(2017) OSTEOARTHRITIS AND CARTILAGE
Raman, S,Mancuso, P,Ryan, A,Murphy, M (2017) INDUCIBLE EXPRESSION OF VIRAL INTERLEUKIN 10 IN MOUSE MESENCHYMAL STEM CELLS INCREASES THEIR IMMUNOSUPPRESSIVE CAPACITY OSTEOARTHRITIS AND CARTILAGE , pp.267-267 [Details]
(2017) Blood
Naicker S, Rigalou A, McEllistrim C, Natoni A, Chiu C, Sasser K, Ryan A, O'Dwyer M (2017) Patient Data Supports the Rationale of Low Dose Cyclophosphamide to Potentiate the Anti-Myeloma Activity of Daratumumab through Augmentation of Macrophage-Induced ADCP Blood [Details]
(2016) Investigative Ophthalmology & Visual Science
Ritter T, Lal C, Treacy O, O'Malley GA, Naicker S, Elbadawy H, Ryan AE, Fahy G, Leahy MJ, Griffin M, Rani S (2016) Extracellular vesicles derived from human mesenchymal stem cells promote corneal wound repair by increasing epithelial cell proliferation and reducing neovascularisation in a rat corneal alkali burn model Investigative Ophthalmology & Visual Science [Details]
(2016) INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
Treacy, O,Murphy, N,Ryan, AE,Lohan, P,Lynch, K,Morcos, M,Fahy, G,Griffin, M,Ritter, T (2016) Licensing of recipient-derived mesenchymal stem cells enhances their immunosuppressive properties and prolongs corneal allograft survival in rats INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE [Details]
(2016) BLOOD
Rigalou, A,Ryan, A,Natoni, A,Chiu, C,Sasser, K,O'Dwyer, ME (2016) Potentiation of Anti-Myeloma Activity of Daratumumab with Combination of Cyclophosphamide, Lenalidomide or Bortezomib Via a Tumor Secretory Response That Greatly Augments Macrophage-Induced ADCP BLOOD [Details]
(2015) INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
Ritter, T,O'Malley, GA,Lohan, P,Ryan, A,Griffin, M,Rani, S (2015) Mesenchymal stem cell-derived extracellular vesicles promote corneal wound repair INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE [Details]
(2015) Endocrine Abstract
Watson, L.; Chen, X.; Ryan, A.; Loftus, P.; McDonnell, P.; O'Brien, T.; Coleman, C.M. (2015) Local administration of non-diabetic MSCs to diabetic femoral fractures enhances callus remodelling and deposition of reparative bone Endocrine Abstract [DOI] [Details]
(2015) OSTEOARTHRITIS AND CARTILAGE
Lohan, P,Treacy, O,Lynch, K,Griffin, M,Ritter, T,Ryan, AE (2015) ALLOGENEIC CHONDROPROGENITORS DISPLAY IMMUNOSUPPRESSIVE PROPERTIES AND ARE NON-IMMUNOGENIC IN VITRO OSTEOARTHRITIS AND CARTILAGE , pp.267-267 [Details]
(2015) FASEB JOURNAL
Ritter, T,Lal, C,Treacy, O,O'Malley, G,Naughton, M,Naicker, S,Lohan, P,Subhash, HM,Ryan, A,Fahy, G,Leahy, M,Griffin, MD,Rani, S (2015) Extracellular Vesicles Derived From Mesenchymal Stem Cells for Treatment of Ocular Surface Injuries FASEB JOURNAL [Details]
(2014) INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
Treacy, O,O'Flynn, L,Ryan, A,Morcos, M,Lohan, P,Schu, S,Wilk, M,Griffin, M,Nosov, M,Ritter, T (2014) Donor- and third party-derived, but not recipient-derived mesenchymal stromal cells, promote corneal allograft survival in rats INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE [Details]
(2014) BJU International
Ridge, M,Ridge, SM,Ryan, AE,Finn, S,O'Leary, J,Giles, FJ,Sullivan, FJ,Glynn, SA (2014) Prostate Cancer Mediated Differentiation of Bone-Marrow Derived Mesenchymal Stem Cells Facilitates Prostate Cancer Cell Invasive and Migratory Capacity . In: BJU INTERNATIONAL, 113, S5, 28-28 eds. BJU International Liverpool, England, [Details]
(2014) IMMUNOLOGY
Lohan, P,Treacy, O,Lynch, K,Coleman, C,Ryan, AE,Ritter, T (2014) Allogeneic rat articular chondrocytes are weakly immunogenic and display potent immunosuppressive ability in vitro IMMUNOLOGY , pp.141-141 [Details]
(2013) Investigative Ophthalmology & Visual Science
Ritter T, Treacy O, Ryan A, Morcos M, Cregg M, Nosov M, O'Flynn L (2013) Understanding the Mechanism of Donor Bone Marrow Derived Dendritic Cells in Promoting Corneal Allograft Survival in the Rat Investigative Ophthalmology & Visual Science [Details]
(2012) Acta Ophthalmologica
L O'Flynn, O Treacy, AE Ryan, M Morcos, M Nosov, T Ritter (2012) Donor bone marrow derived dendritic cells promote corneal allograft survival in the rat Acta Ophthalmologica [Details]
(2012) Investigative Ophthalmology & Visual Science
Ritter T, Nosov M, Ryan A, Treacy O, Cregg M, Fahy G, Morcos M, O'Flynn L (2012) Bone Marrow Derived Dendritic Cells Prevent Corneal Allograft Rejection In The Rat Investigative Ophthalmology & Visual Science [Details]
(2012) JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
Fahy, N,Farrell, E,Ryan, A,Harte, M,Ritter, T,Murphy, M (2012) Attenuation of inflammation by immune modulation for cartilage repair in osteoarthritis JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE , pp.63-63 [Details]
(2012) Investigative Ophthalmology & Visual Science
Treacy O, Ryan A, Morcos M, O'Flynn L, Wilk M, Schu S, Cregg M, Nosov M, Ritter T (2012) Mesenchymal Stem Cell Therapy Prolongs Corneal Allograft Survival in Rats Investigative Ophthalmology & Visual Science [Details]
(2011) Acta Ophthalmologica
Ritter T, Treacy M, Wilk M, MORCOS M, O'FLYNN L, RYAN A, NOSOV M (2011) Novel therapeutic strategies for the induction of tolerance in cornea transplantation Acta Ophthalmologica [DOI] [Details]
(2010) Gastroenterology
Ryan AE, Colleran A, O'Gorman A, Mureau C, Egan LJ (2010) Inhibition of NF-kappa B in Colon Cancer Cells Prevents Peritoneal Dissemination Through Polarisation of Tumor-Associated Macrophages Towards an M1-Like Phenotype . In: W1861 eds. Gastroenterology [Details]
(2010) Gastroenterology
Colleran A, Ryan AE, O'Gorman A, Liptrot CH, Dockery P, Egan LJ (2010) TNF-alpha-Induced Long-Term NF-kappa B Activation in Intestinal Epithelial Cells: Evidence for Autophagic Degradation of I kappa B alpha Gastroenterology [Details]
(2010) Gastroenterology
Ali RA, Zulquernain SA, Ryan AE, Colleran A, Hartnett L, Ogorman A, Lee JM, Egan LJ (2010) Analysis of the IL-6/STAT3/AKT Signalling Pathways in Patients With Inflammatory Bowel Disease: Effect of Disease Activity and Duration Gastroenterology [Details]
(2009) Gastroenterology
Ryan AE, Colleran A, O'Gorman A, Mureau C, Foran E, Egan L (2009) Inhibition of NF-kappa B in Colon Cancer Cells Significantly Decreases Tumour Burden and Increases Survival Time in a Mouse Model of Peritoneal Metastasis Gastroenterology [Details]
(2005) Endoscopy
Ryan AE, Shanahan F, O'Connell J, Houston AM (2005) Resolving the Fas counterattack controversy: Fas ligand promotes tumour immune evasion of colon cancer in vivo Endoscopy , pp.T1450-A-481 [Details]
(2005) Gastroenterology
Ryan AE, Houston A, Lane S, Kelly J, Shanahan F, O'Connell J (2005) Resolving the Fas Counterattack controversy: Fas ligand promotes tumor immune evasion of colon cancer in vivo Gastroenterology [Details]

Book Chapters

  Year Publication
(2017) 'Mesenchymal Stem/Stromal cell Therapy: mechanism of action and host response'
Ryan AE, Murphy MM, Barry FP (2017) 'Mesenchymal Stem/Stromal cell Therapy: mechanism of action and host response' In: Biology and Therapeutic Applications of Mesenchymal Stromal Cells. :426-440 USA: Wiley Publishers. [DOI] [Details]
(2014) 'Mechanisms of Nitric Oxide Dependent Regulation of Tumour Invasion and Metastasis'
Ryan AE, Burke AJ, Sullivan FJ, Glynn SA (2014) 'Mechanisms of Nitric Oxide Dependent Regulation of Tumour Invasion and Metastasis' In: NO and Cancer - Prognosis, Prevention and Therapy. :49-64 USA: Springer. [DOI] [Details]

Article

  Year Publication
(2019) FLIP(L) determines p53 induced life or death.
Lees A, McIntyre AJ, Falcone F, Crawford NT,McCann C, Quinn GP, Roberts JZ, Sessler T, Gallagher PF, Gregg GMA, McAllister K, McLaughlin KM, Allen WL, Holohan C, Egan LJ, Ryan AE, Labonte-Wilson M, Dunne PD, Wappett M, Coyle VM, Johnston PG, Kerr EM, Longley DB, McDade SS (2019) FLIP(L) determines p53 induced life or death. BioRxiv Article [DOI] [Details]

Book Review

  Year Publication
(2019) Subconjunctival injection of low-dose mesenchymal stem cells promotes corneal allograft survival in a mouse cornea transplantation model.
Ritter, T,Donohoe, E,Treacy, O,Lynch, K,Chen, XZ,Fahy, G,Ryan, AE,Murphy, N (2019) Subconjunctival injection of low-dose mesenchymal stem cells promotes corneal allograft survival in a mouse cornea transplantation model. Book Review [Details]
(2016) Extracellular Vesicles Derived From Mesenchymal Stem Cells for Treatment of Ocular Surface Injuries.
Ritter, T,Lal, C,Treacy, O,O'Malley, G,Naughton, M,Naicker, S,Lohan, P,Subhash, HM,Ryan, A,Fahy, G,Leahy, M,Griffin, MD,Rani, S (2016) Extracellular Vesicles Derived From Mesenchymal Stem Cells for Treatment of Ocular Surface Injuries. Book Review [Details]
(2016) Extracellular Vesicles Derived From Mesenchymal Stem Cells for Treatment of Ocular Surface Injuries.
Ritter, T,Lal, C,Treacy, O,O'Malley, G,Naughton, M,Naicker, S,Lohan, P,Subhash, HM,Ryan, A,Fahy, G,Leahy, M,Griffin, MD,Rani, S (2016) Extracellular Vesicles Derived From Mesenchymal Stem Cells for Treatment of Ocular Surface Injuries. Book Review [Details]

Invited Seminars

  Year Publication
(2012) The Immunology Seminar Series, NUI Maynooth.
Ryan, AE (2012) The Immunology Seminar Series, NUI Maynooth. Invited Seminars [Details]
(2012) Biochemistry Seminar Series’, University College Cork.
Ryan, AE (2012) Biochemistry Seminar Series’, University College Cork. Invited Seminars [Details]
(2011) PRTLI Workshop on ‘Inflammation’, Trinity College Dublin.
Ryan, AE (2011) PRTLI Workshop on ‘Inflammation’, Trinity College Dublin. Invited Seminars [Details]
(2009) Irish Epithelial Physiology Group (IEPG), Kilkenny.
Ryan, AE (2009) Irish Epithelial Physiology Group (IEPG), Kilkenny. Invited Seminars [Details]

Presented Papers

  Year Publication
(2013) Irish Association for Cancer research.
Ryan, AE (2013) Irish Association for Cancer research. Presented Papers [Details]
(2012) Keystone Symposium on ‘The role of Inflammation during Carcinogenesis’.
Ryan, AE (2012) Keystone Symposium on ‘The role of Inflammation during Carcinogenesis’. Presented Papers [Details]
(2005) Irish Society Gastroenterology.
Ryan, AE (2005) Irish Society Gastroenterology. Presented Papers [Details]

Published abstracts

  Year Publication
(2020) Beyond DNA Damage: Exploring the Immunomodulatory Effects of Cyclophosphamide in Multiple Myeloma.
Swan, D;Gurney, M;Krawczyk, J;Ryan, AE;O'Dwyer, M (2020) Beyond DNA Damage: Exploring the Immunomodulatory Effects of Cyclophosphamide in Multiple Myeloma. PHILADELPHIA: LIPPINCOTT WILLIAMS & WILKINS Published abstracts [DOI] [Details]

Reviews

  Year Publication
(2018) Extracellular vesicles as modulators of wound healing.
Cabral, J;Ryan, AE;Griffin, MD;Ritter, T (2018) Extracellular vesicles as modulators of wound healing. AMSTERDAM: ELSEVIER SCIENCE BV Reviews [DOI] [Details]
(2016) Mesenchymal stromal cells (MSCs) and colorectal cancer - a troublesome twosome for the anti-tumour immune response?.
O'Malley, G;Heijltjes, M;Houston, AM;Rani, S;Ritter, T;Egan, LJ;Ryan, AE (2016) Mesenchymal stromal cells (MSCs) and colorectal cancer - a troublesome twosome for the anti-tumour immune response?. ORCHARD PARK: IMPACT JOURNALS LLC Reviews [DOI] [Details]
(2015) Mesenchymal Stem Cell-derived Extracellular Vesicles: Toward Cell-free Therapeutic Applications.
Rani, S;Ryan, AE;Griffin, MD;Ritter, T (2015) Mesenchymal Stem Cell-derived Extracellular Vesicles: Toward Cell-free Therapeutic Applications. CAMBRIDGE: CELL PRESS Reviews [DOI] [Details]
(2014) Changes in immunological profile of allogeneic mesenchymal stem cells after differentiation: should we be concerned?.
Lohan, P;Coleman, CM;Murphy, M;Griffin, MD;Ritter, T;Ryan, AE (2014) Changes in immunological profile of allogeneic mesenchymal stem cells after differentiation: should we be concerned?. LONDON: BIOMED CENTRAL LTD Reviews [DOI] [Details]
(2013) Anti-donor immune responses elicited by allogeneic mesenchymal stem cells: what have we learned so far?.
Griffin, MD;Ryan, AE;Alagesan, S;Lohan, P;Treacy, O;Ritter, T (2013) Anti-donor immune responses elicited by allogeneic mesenchymal stem cells: what have we learned so far?. HOBOKEN: WILEY Reviews [DOI] [Details]

Honours and Awards

  Year Title Awarding Body
2018 Sparkathon 'Future Leader' Award Society for Immunotherapy of Cancer
2018 NCI Cancer Prevention Fellowship Health research Board, National cancer Institute, USA
2018 Presidents Award for Research Excellence Presidents Office, NUI Galway
2017 Recognition as one of the top 3 Cancer Researchers in Ireland for 'Researcher of the year' Irish Cancer Society
2016 Shortlisted for Researcher of the Year Award Irish Cancer Society
2016 Best Clinical Research Presentation Haematology Association of Ireland
2016 Starting Investigator Award Science Foundation Ireland
2016 IRC nomination attendee at the Preseidents address to Women in Science Irish Research Council
2015 Best Reseach Poster Presentation The Irish Association of Cancer Research
2015 European Cancer Research Young Investigator Award European Association for Cancer Research
2015 Highly Rcommended shortlst 'Presidents awards for research excellence' National University of Ireland, Galway
2015 Best Research Poster Irish Association of Cancer Research
2014 Lindau Nobel Laureate Meeting Award Lindau Nobel Laureate Council & The Irish Research Council
2013 Irish Cancer Society Research Fellowship Irish Cancer Society
2012 Best Research Presentation The Irish Society of Immunology
2007 Best Research Presentation Irish Association of Cancer Research
2005 Research Travel Scholarship Irish Cancer Society

Professional Associations

  Association Function From / To
European Association of Cancer Research Member 31-MAY-20 / 31-MAY-21
Irish Association of Cancer Research Member 23-MAY-20 /
American Society of Haematology Active Member 01-NOV-19 /
American Association of Cancer Research Active Member 01-NOV-18 /
Matrix Biology Ireland Committee Member 01-OCT-19 /
Haematology Association of Ireland Active Member 01-OCT-19 /
Irish Society of Immunology Member 30-MAY-12 / 12-MAY-16
Irish Flow Cytometry Society Member 01-OCT-12 /
Society for Immunotherapy for Cancer Active Member 01-FEB-20 / 01-JAN-21

Committees

  Committee Function From / To
School of Medicine Research Committee Committee Member 01-DEC-17 /
School of Medicine Athena Swan Committee Member Committee Member 01-FEB-17 /
Research Advisory Board Irish Cancer Society Advisor to the research portfolio of the charity 15-NOV-16 /
Undergraduate Research Commitee Member of Commitee 01-SEP-14 /
Graduate Research Commitee GRC Commitee member 01-JUL-14 / 30-JUN-17

Employment

  Employer Position From / To
Prof Laurence Egan, NUI Galway Post Doctoral Fellow 01-AUG-06 / 31-MAR-10
NUI Galway Research Fellow 01-JAN-13 / 01-MAY-16
Prof Thomas Ritter, NUI Galway Senior Post Doctoral Fellow 04-NOV-10 / 31-DEC-12
NUI Galway SFI Funded Starting Investigator 01-DEC-16 /

Education

  Year Institution Qualification Subject
2010 Project Management Institute Certificate Project Management
2018 NUI Galway Postgraduate Certificate in Teaching & Learning in Higher Education Teaching and Learning
2001 National University of Ireland, Galway BSc (Hons) Biochenistry, Microbiology
2006 University College Cork PhD Medicine

Languages

  Language
Irish
English

Community Engagement

  Title Type From / To
Outreach Cell Explorers School Visits 01-NOV-17 /
Outreach Research Advocate at the Irish Cancer Society Daffodil Day launch 03-MAR-16 /
Outreach Adjudicator for 'Reellife' Science Competition 04-FEB-14 / 30-NOV-15
Outreach Pint of Science Talk 03-FEB-16 /
Outreach Irish Cancer Society Fundraising Research Showcase 30-JUN-13 / 27-MAY-13
Board Membership Research Advisory Board of the Irish Cancer Society 16-NOV-16 /
Research (e.g. Community based research) Irish Cancer Society Research Day launch 09-JUN-14 / 09-JUN-14

Reviews

  Journal Role
Stem Cell Research And Therapy Reviewer
Journal Of Tissue Engineering And Regenerative Medicine Editoral Board
Immunology And Cell Biology Reviewer
Osteoarthritis And Cartilage Reviewer
Transplantation Reviewer
Cells Tissues Organs Reviewer
Stem Cell Reviews And Reports Reviewer
Transplant immunology Reviewer
Molecular Therapy Reviewer
Stem Cells And Development Reviewer
Plos One Reviewer

Teaching Interests

My teaching interests include:

Cancer cell Signalling
Immuno-pharmacology
Allogeneic Cellular therapy and Host Responses
Immune Microenvironment in Cancer
Immunotherapies for the treatment of Cancer
Gastrointestinal Cancers
Mechanisms of Immune evasion in Cancer
Strategies to modulate the immune microenvironment in cancer



 

Recent Postgraduate Students

  Graduation Name Degree Primary Supervisor
2018 Grace O'Malley PhD Y
2016 Paul Lohan PhD Y

Modules Taught

  Term/Year Module Title Module Code Subject / Desc
2012-2018 Clinical Oncology, Haematology B1461 Gastrointestinal Cancers
2016/2017 Molecular Pharmacology 1617-PM434
2016/2017 Clinical Oncology - Haematology 1617-B1461
2016/2017 Advnaced and Applied Immunology 1617-MD536
2020/21 Advanced and Applied Immunology MD536 Cancer Immunology ans Immunotherapies
2016/2017 Pharmacology Research Project 1617-PM431
2019/20 Course in Basic and Applied Immunology REM508 Cancer and stromal cell immunology
2019/2020 Clinical Oncology, Haematology B1461 Gastrointestinal Cancers
2020/21 Course in Basic and Advanced Immunology REM508 Stem Cell Immunology
2015-2016 Basic and Advanced Immunology 1516-REM508 Stem Cell transplantation
2016/2017 Stem Cells and Gene Therapy 1617-PM507
2020/21 Clinical Oncology, Haematology B1461 Gastrointestinal Cancers
2016/2017 Immunopharmacology 1617-PM435
2016/2017 Basic and Advanced Immunology 1617-REM508
2016/2017 Experimental Neuropharmacology 1617-PM5103
2016/2017 Experimental Toxicology 1617-PM5109

Internal Collaborators

  Name Description of Collaboration
Prof Laurence Egan
Joint supervision of PhD students, Joint research projects and joint research publications
Dr Sharon Glynn
Dr Glynn provides expertise on tumour biology, inflammation and tumour metabolites in the tumour microenvironment
Dr Mary Murphy
Dr Roisin Dwyer
Dr Dwyer provides expertise on iin vivo imaging, extracellualr vesicles, stem cell & tumor biology
Prof Michael O'Dwyer
Joint Research Projects and Joint Publications and Patents

External Collaborators

  Name Organisation / Institute Country Description of Collaboration
Dr Christopher Chiu Janssen Pharmaceuticals U.S.A.
Advisor on Industry funded collaboration with Janssen
Prof Karin Vanderkerken VUB BELGIUM
Collaborator role on MMRF Fellowship application
Dr Philip Dunne Queens University Belfast UNITED KINGDOM
Dr Dunne provides expertise on big data analysis, immunohistochemistry and bioinformatics for my research programme
Dr David Wink National Cancer Insititute, Frederick, MD, USA U.S.A.
Dr Wink provides expertise in metabolic and biochemical regulation of immune effector molecules in the tumour microenvironment e.g. Nitric Oxide and Arginnine