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Biological and Chemical Sciences

Prof James P O'Gara

BSc, PhD, DSc, MRIA

Contact Details

Personal Professor
Microbiology Room 101
Arts/Science Building
School of Biological and Chemical Sciences
South Campus
E: jamesp.ogara@universityofgalway.ie
 
researcher
 

Biography

Jim O'Gara completed his PhD in the laboratory of L. Kieran Dunican at the University of Galway investigating the genetic basis of tryptophan overproduction in Corynebacterium glutamicum. During his first postdoctoral fellowship at the University of Texas Medical School Houston in Samuel Kaplan's laboratory he discovered a novel relationship between the activity of electron transport chain redox carriers and transcriptional regulation of photosynthesis gene expression, and a new mechanism of resistance to the heavy metal tellurite in Rhodobacter sphaeroides. Returning to Ireland in 1997 for a postdoctoral fellowship at Trinity College Dublin in the laboratory of Charles J. Dorman, he revealed how fimB promoter-driven transcription across the fim switch impacts phase variable expression of type 1 fimbriae in E. coli.
Jim was appointed to a lectureship in microbiology at RCSI in 1999 and established a research programme investigating virulence and antimicrobial resistance (AMR) mechanisms in staphylococci, including MRSA. In 2005, he was appointed Senior Lecturer in Microbiology at University College Dublin, and returned to his alma mater as Professor of Infectious Disease Microbiology in 2012.
Prof O'Gara's research group are focused on the identification and characterisation of new drug targets, from which new therapeutic interventions can be developed for the improved treatment of AMR and chronic infections. Notable scientific contributions from his group include i) the first description of the major transcriptional regulator of staphylococcal biofilm production (IcaR), ii) the identification of novel biofilm mechanisms mediated by 1. the fibronectin binding proteins, 2. the major autolysin and 3. coagulase in S. aureus, iii) elucidating the relationship between methicillin resistance, biofilm and virulence in S. aureus, iv) new therapeutic approaches to the treatment of chronic MRSA infections, including beta-lactam/nucleoside combinations, and (v) the discovery of new drug targets to increase the effectiveness of beta-lactams against MRSA (including alanine transport systems and succinyl-CoA synthetase-controlled regulation of lysine succinylation in the proteome).
Prof O'Gara was awarded a DSc from the National University of Ireland in 2018, and was elected a Member of the Royal Irish Academy (MRIA) in 2022.

2022: Elected Member of the Royal Irish Academy (MRIA)
2021-2025: Member University of Galway Governing Authority
2018: DSc (National University of Ireland)
2013- 2016: Head of Microbiology, University of Galway.
2012- Present: Personal Professor of Microbiology, University of Galway.
2007-2012: Head of Graduate Studies, School of Biomolecular and Biomedical Science, UCD.
2007-2012: Conway Fellow, Conway Institute of Biomolecular & Biomedical Research, UCD.
2005-2012: Senior Lecturer (Microbiology), University College Dublin
2004-2005: Senior Lecturer (Microbiology), Royal College of Surgeons in Ireland
1999-2004: Lecturer (Microbiology), Royal College of Surgeons in Ireland
1997-1999: Postdoctoral Research Fellow, Department of Microbiology, Trinity College Dublin
1994-1997: Postdoctoral Research Fellow, The University of Texas Medical School, Houston, TX.
1990-1994: PhD (Microbiology), University of Galway 

Research Interests

Overcoming antimicrobial resistance (AMR) in MRSA and other AMR pathogens. More than 25,000 people die because of AMR infections in the EU each year. The global number of deaths may be as high as 700,000. In the United States, there are more than 80,000 invasive MRSA infections every year responsible for >11,000 deaths (2013 Centre for Disease Control report). MRSA ranks as the 6th most common cause of bacterial infection and #1 in terms of mortality, despite most patients being treated with currently available anti-staphylococcal drugs. New drug development has not been able to keep pace with the emergence of so-called superbugs and the 2016 UK-government commissioned O’Neill report warned that, without intervention, infections caused by AMR pathogens will be responsible for more deaths than cancer in 2050. 

Penicillin-type antibiotics target the bacterial cell wall and remain among the safest and most effective antibiotics. However resistance is widespread. The O’Gara research group have identified new drug targets to increase the effectiveness of penicillin-type antibiotics, even against resistant bacteria like MRSA. The biological functions of these new drug targets and their mechanistic role in antibiotic resistance are currently being investigated using funding from SFI (Frontiers for the Future Programme), HRB (Investigator Led Project Grants) and IRC Postgraduate Scholarships. These targets include alanine transporters required for MRSA cell wall integrity, succinyl-CoA synthetase which controls resistance to beta-lactam antibiotics via post-translational regulation of lysine succinylation in the proteome, and nucleoside transporters which control purine homeostasis required for high-level antibiotic resistance in MRSA. All of these new drug targets have the potential to impact antibiotic resistance in other AMR pathogens on the World Health Organisation’s list of global priority pathogens (the ESKAPE group: Enterococcus faecium, Staphylococcus aureus (MRSA), Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp).   

Chronic biofilm-associated infections. The increased incidence of chronic biofilm-associated infections in healthcare systems has serious consequences in patient morbidity, mortality and treatment costs. Hospital-acquired infections are the 4th leading cause of disease and 70% are associated with medical devices. Implants are highly susceptible to the formation of biofilm, making bacteria resistant to the immune system and antibiotics. Biofilms are also involved in diabetic foot infections (DFIs), which are a major complication of diabetes, with peripheral neuropathy often contributing to delayed diagnosis of these chronic infections.  Biofilms are enriched with highly antibiotic-tolerant persister cells frequently rendering antibiotic treatment ineffective, which has major consequences for the patient, as well as placing an enormous economic burden on healthcare systems.

Press Releases:

17th January 2023. https://www.universityofgalway.ie/about-us/news-and-events/news-archive/2023/january/scientists-disc...#
MRSA can be efficiently killed by penicillin-type antibiotics when combined with purines, which are the building blocks for DNA, revealing a potentially new way to treat MRSA infections with these drugs, which remain the safest and most effective antibiotics. The research was published in mBio https://journals.asm.org/doi/10.1128/mbio.02478-22 and discussed in the American Society for Microbiology (ASM) This Week in Microbiology (TWiM) Dec 29th 2022 podcast.

29th June 2021. https://www.nuigalway.ie/about-us/news-and-events/news-archive/2021/june/nui-galway-study-identifies...
NUI Galway Study Identifies New Ways to Treat Antibiotic Resistant MRSA Superbug

15th November 2016. https://www.rte.ie/news/2016/1115/831844-mrsa/
Galway researchers find penicillin aids MRSA fight

9th July 2015. https://tinyurl.com/427wjbz9. Breaking up MRSA - new discovery could reduce device-related infections in hospitals.

Research Projects

  Project Start Date End Date
TARGETING MEMBRANE TRANSPORTERS TO INCREASE ANTIBIOTIC SUSCEPTIBILITY IN BACTERIAL PATHOGENS (SFI Frontiers for the Future. PI) 01-DEC-20 31-MAY-25
USING GUANINE TO RE-SENSITISE MRSA TO METHICILLIN: IS PURINE NUCLEOTIDE HOMEOSTASIS THE ACHILLES' HEEL OF MRSA ANTIBIOTIC RESISTANCE? HRB Investigator Led Project. PI. 01-DEC-19 31-MAR-24
DIABETIC FOOT DISEASE: FROM PREVENTION TO TREATMENT TO IMPROVED PATIENT OUTCOMES (DFD PRIMO). HRB Collaborative Doctoral Award. Co I 01-SEP-20 31-DEC-24
REPURPOSING D-CYCLOSERINE AND RELATED DRUGS TO OVERCOME RESISTANCE RESISTANCE TO BETA-LACTAM ANTIBIOTICS IN BACTERIAL PATHOGENS 01-JAN-17 31-MAR-22
NEW TREATMENTS FOR TREATMENT OF MRSA INFECTIONS J O GARA 01-OCT-14 30-SEP-22
REDUCING RESISTANCE TO BETA-LACTAM ANTIBIOTICS; A NEW TREATMENT STRATEGY FOR MRSA INFECTIONS 01-OCT-16 30-NOV-23
IRC POSTGRADUATE SCHOLARSHIP 2019 ORLA BURKE - ELUCIDATING WHY THE TCA CYCLE ENZYME SUCCINYL-COA SYNTHETASE INFLUENCES RESISTANCE TO ß-LACTAM ANTIBIOTICS IN MRSA: A NEW TARGET FOR ANTIMICROBIAL DRUG THERAPY? 01-SEP-19 31-AUG-23
WOUND INFECTIONS: BIOFILMS AND THE SEARCH FOR NOVEL ANTIMICROBIAL AGENTS. HRB Investigator Led Project. Co-I 01-DEC-19 31-MAY-24
IRC POSTGRADUATE SCHOLARSHIP 2016 CLAIRE FINGLETON - New frontiers in the treatment of MRSA infections: Using amino acid analogues to overcome resistance to beta-lactam antibiotics 01-OCT-16 30-SEP-20
IRC POSTGRADUATE SCHOLARSHIP 2018 Moya Vallely - Usng drug combinations to ESKAPE the roblem of antimicrobial resistance and tolerance 01-OCT-18 30-SEP-22
TOWARDS IMPROVED PREVENTION AND TREATMENT OF DEVICE RELATED INFECTIONS(DVIS) JIM O GARA 01-FEB-13 30-SEP-13
TOWARDS IMPROVED PREVENTION AND TREATMENT OF DEVICE RELATED INFECTIONS(DVIS) JIM O GARA 01-OCT-13 30-SEP-14
JIM O GARA INVESTIGATING THE RELATIONSHIP BETWEEN METHICILLIN RESISTANCE , BIOFILM AND VIRULENCE IN STAPHLOCCUS AUREAUS 01-NOV-12 31-OCT-15
BIOFLUX MICROFLUIDICS SYSTEM FOR CELL ANALYSIS UNDER J O GARA 01-JAN-13 31-DEC-14
POSTDOCTORAL SCHOLARSHIP 2018 YINKA SOMORIN - ELUCIDATING THE MOLECULAR RESPONSE OF STAPHYLOCOCCUS AUREUS TO VISIBLE LIGHT AND DEVELOPMENT OF A LIGHT-BASED THERAPY FOR STAPHYLOCOCCAL BIOFILM RELATED INFECTIONS 01-JAN-19 31-DEC-20

Contract Researchers

  Researcher Name Project Role Funding Body
Dr Rakesh Roy TARGETING MEMBRANE TRANSPORTERS TO INCREASE ANTIBIOTIC SUSCEPTIBILITY IN BACTERIAL PATHOGENS Postdoctoral Researcher Science Foundation Ireland (SFI)

Peer Reviewed Journals

  Year Publication
(2024) 'The pathogenicity and virulence of the opportunistic pathogen Staphylococcus epidermidis'
Burke ÓM, Zeden MS, O'Gara JP. (2024) 'The pathogenicity and virulence of the opportunistic pathogen Staphylococcus epidermidis'. Virulence, 15 (1) [Details]
(2023) 'Metabolic reprogramming and altered cell envelope characteristics in a pentose phosphate pathway mutant increases MRSA resistance to ß-lactam antibiotics'
Zeden MS, Gallagher LA, Bueno E, Nolan A, Ahm J, Shinde D, Razvi F, Sladek M, Burke O, O'Neill E, Fey PD, Cava F, Thomas VC, O'Gara JP (2023) 'Metabolic reprogramming and altered cell envelope characteristics in a pentose phosphate pathway mutant increases MRSA resistance to ß-lactam antibiotics'. Plos Pathogens, 19 [Details]
(2023) 'Staphylococcus Great Britain and Ireland 2023 (StaphGBI 2023) Conference Report'
O'Gara JP, Zeden MS (2023) 'Staphylococcus Great Britain and Ireland 2023 (StaphGBI 2023) Conference Report'. Access Microbiology, 5 (12) [Details]
(2023) 'Purine nucleosides interfere with c-di-AMP levels and act as adjuvants to re-sensitise MRSA to beta-lactam antibiotics'
Nolan AC, Zeden MS, Campbell C, Kviatkovski I, Urwin L, Corrigan RM, Gründling A, O'Gara JP (2023) 'Purine nucleosides interfere with c-di-AMP levels and act as adjuvants to re-sensitise MRSA to beta-lactam antibiotics'. Mbio, 14 [Details]
(2023) 'Signs, symptoms and/or biomarkers reported to indicate biofilm in chronic wounds: an edelphi consensus protocol'
Ivory JD., Sezgin D., Coutts PM., Roshan D., Hobbs C., Soriano JV., O'Gara JP., Gallagher D., and Gethin G. (2023) 'Signs, symptoms and/or biomarkers reported to indicate biofilm in chronic wounds: an edelphi consensus protocol'. Journal of Wound Management, 16 (2):22-27 [DOI] [Details]
(2023) 'Sponge-derived fatty acids inhibit biofilm formation of MRSA and MSSA by down-regulating biofilm-related genes specific to each pathogen'
Khan N, Barthes N, McCormack G, O'Gara JP, Thomas O, Boyd A (2023) 'Sponge-derived fatty acids inhibit biofilm formation of MRSA and MSSA by down-regulating biofilm-related genes specific to each pathogen'. Journal Of Applied Microbiology, 134 [DOI] [Details]
(2021) 'Accumulation of succinyl-CoA perturbs the MRSA succinylome and is associated with increased susceptibility to beta-lactam antibiotics'
Campbell C*, Fingleton C*, Zeden MS, Bueno E, Gallagher LA, Shinde D, Ahn J, Olson HM, Fillmore TL, Adkins JN, Razvi F, Bayles KW, Fey PD, Thomas VC, Cava F, Clair GC, O’Gara JP (2021) 'Accumulation of succinyl-CoA perturbs the MRSA succinylome and is associated with increased susceptibility to beta-lactam antibiotics'. Mbio, 12 [Details]
(2021) 'Exploring amino acid and peptide transporters as therapeutic targets to attenuate virulence and antibiotic resistance in Staphylococcus aureus'
Zeden MS, Burke O, Vallely M, Fingleton C, O’Gara JP (2021) 'Exploring amino acid and peptide transporters as therapeutic targets to attenuate virulence and antibiotic resistance in Staphylococcus aureus'. Plos Pathogens, 17 [Details]
(2021) 'The Novel Membrane-Associated Auxiliary Factors AuxA and AuxB Modulate -lactam Resistance in MRSA by stabilizing Lipoteichoic Acids'
Mikkelsen K, Sirisarn W, Alharbi O, Alharbi M, Liu H, Nøhr-Meldgaard K, Mayer K, Vestergaard M, Gallagher LM, Derrick JP, McBain AJ, Biboy J, Vollmer W, O’Gara JP, Grunert T, Hanne Ingmer H, Xia G. (2021) 'The Novel Membrane-Associated Auxiliary Factors AuxA and AuxB Modulate -lactam Resistance in MRSA by stabilizing Lipoteichoic Acids'. International Journal Of Antimicrobial Agents, 57 [Details]
(2021) 'Osteointegration, antimicrobial and antibiofilm activity of orthopaedic titanium surfaces coated with silver and strontium-doped hydroxyapatite using a novel blasting process'
O' Sullivan C, O'Neill L, O'Leary ND, O'Gara JP, Crean AM, Ryan KB. (2021) 'Osteointegration, antimicrobial and antibiofilm activity of orthopaedic titanium surfaces coated with silver and strontium-doped hydroxyapatite using a novel blasting process'. Drug Delivery And Translational Research, 11 [DOI] [Details]
(2021) 'Enzyme-functionalized mesoporous silica nanoparticles to target Staphylococcus aureus and disperse biofilms'
Devlin H, Fulaz S, Hiebner D, O'Gara JP, Casey E. (2021) 'Enzyme-functionalized mesoporous silica nanoparticles to target Staphylococcus aureus and disperse biofilms'. International Journal Of Nanomedicine, 16 [Details]
(2020) 'Tailoring Nanoparticle-Biofilm Interactions to Increase the Efficacy of Antimicrobial Agents Against Staphylococcus aureus'
Fulaz S, Devlin H, Vitale S, Quinn L, O'Gara JP, Casey E. (2020) 'Tailoring Nanoparticle-Biofilm Interactions to Increase the Efficacy of Antimicrobial Agents Against Staphylococcus aureus'. International Journal Of Nanomedicine, 15 [DOI] [Details]
(2020) 'Glycomics Microarrays Reveal Differential In Situ Presentation of the Biofilm Polysaccharide Poly-N-acetylglucosamine on Acinetobacter baumannii and Staphylococcus aureus Cell Surfaces'
Flannery A, Le Berre M, Pier GB, O'Gara JP, Kilcoyne M. (2020) 'Glycomics Microarrays Reveal Differential In Situ Presentation of the Biofilm Polysaccharide Poly-N-acetylglucosamine on Acinetobacter baumannii and Staphylococcus aureus Cell Surfaces'. International Journal Of Molecular Sciences, 21 [DOI] [ARAN Link] [Details]
(2020) 'Impaired Alanine Transport or Exposure to D-Cycloserine Increases the Susceptibility of MRSA to beta-lactam Antibiotics'
Gallagher LA, Shears RK, Fingleton C, Alvarez L, Waters EM, Clarke J, Bricio-Moreno L, Campbell C, Yadav AK, Razvi F, O'Neill E, O'Neill AJ, Cava F, Fey PD, Kadioglu A, O'Gara JP. (2020) 'Impaired Alanine Transport or Exposure to D-Cycloserine Increases the Susceptibility of MRSA to beta-lactam Antibiotics'. Journal Of Infectious Diseases, 221 [DOI] [Details]
(2019) 'A novel medical device coating prevents Staphylococcus aureus biofilm formation on medical device surfaces'
Hogan S, Kasotakis E, Maher S, Cavanagh B, O'Gara JP, Pandit A, Keyes TE, Devocelle M, O'Neill E. (2019) 'A novel medical device coating prevents Staphylococcus aureus biofilm formation on medical device surfaces'. Fems Microbiol Lett, 366 (9) [Details]
(2019) 'Complete Genome Sequence of Staphylococcus epidermidis CSF41498'
Galac MR, Hoang TM, Ong AC, Hinkle M, O'Gara JP, Fey PD. (2019) 'Complete Genome Sequence of Staphylococcus epidermidis CSF41498'. Microbiology Resource Announcements, 8 [DOI] [Details]
(2018) 'Novel treatment of Staphylococcus aureus device-related infections using fibrinolytic agents'
Hogan S, O'Gara JP, O'Neill E. (2018) 'Novel treatment of Staphylococcus aureus device-related infections using fibrinolytic agents'. Antimicrobial Agents And Chemotherapy, 62 [Details]
(2017) 'Tandem amplification of SCCmec can drive high level methicillin resistance in MRSA'
Gallagher LA, Coughlan S, Black NS, Lalor P, Waters EM, Wee B, Watson M, Downing T, Fitzgerald JR, Fleming GTA, O’Gara JP. (2017) 'Tandem amplification of SCCmec can drive high level methicillin resistance in MRSA'. Antimicrob Agents Chemother, 61 [Details]
(2017) 'Redeploying ß-lactam antibiotics as a novel anti-virulence strategy for the treatment of MRSA infections'
Waters EM, Rudkin JK, Coughlan S, Clair GC, Adkins JN, Gore S, Xia G, Black NS, Downing T, O'Neill E, Kadioglu A, O’Gara JP. (2017) 'Redeploying ß-lactam antibiotics as a novel anti-virulence strategy for the treatment of MRSA infections'. Journal Of Infectious Disease, 215 [Details]
(2017) 'Into the Storm: Chasing the opportunistic pathogen Staphylococcus aureus from skin colonisation to life threatening infections'
O'Gara JP (2017) 'Into the Storm: Chasing the opportunistic pathogen Staphylococcus aureus from skin colonisation to life threatening infections'. Environmental Microbiology, 19 [Details]
(2017) 'Eradication of Staphylococcus aureus biofilm infections using synthetic antimicrobial peptides'
Zapotoczna M, Forde E, Hogan S, Humphreys H, O’Gara JP, Fitzgerald-Hughes D, Devocelle M, O’Neill E. (2017) 'Eradication of Staphylococcus aureus biofilm infections using synthetic antimicrobial peptides'. Journal Of Infectious Diseases, 215 [Details]
(2017) 'Novel anti-staphylococcal and anti-biofilm properties of two anti-malarial compounds; MMV665953 (1-(3-Chloro-4-fluorophenyl)-3-(3,4-dichlorophenyl)urea) and MMV665807 (5-Chloro-2-hydroxy-N-[3-(trifluoromethyl)phenyl]benzamide'
Zapotoczna M, Boksmati N, Donohue S, Bahtiar B, Boland A, Al Somali M, Cox A, Humphreys H, O'Gara JP, Brennan M, O'Neill E. (2017) 'Novel anti-staphylococcal and anti-biofilm properties of two anti-malarial compounds; MMV665953 (1-(3-Chloro-4-fluorophenyl)-3-(3,4-dichlorophenyl)urea) and MMV665807 (5-Chloro-2-hydroxy-N-[3-(trifluoromethyl)phenyl]benzamide'. Journal Of Medical Microbiology, 66 [Details]
(2017) 'Potential use of targeted enzymatic agents in the treatment of Staphylococcus aureus biofilm related infections'
Hogan S, Zapotaczna M, Stevens N, Humphreys H, O'Gara JP, O'Neill E. (2017) 'Potential use of targeted enzymatic agents in the treatment of Staphylococcus aureus biofilm related infections'. Journal Of Hospital Infection, 96 [Details]
(2017) '5-Hydroxyethyl-3-tetradecanoyltetramic acid represents a novel treatment for intravascular catheter infections due to Staphylococcus aureus'
Zapotoczna M, Murray E, Hogan S, O’Gara JP, Chhabra SR, Chan WC, O’Neill E, Williams P (2017) '5-Hydroxyethyl-3-tetradecanoyltetramic acid represents a novel treatment for intravascular catheter infections due to Staphylococcus aureus'. Journal Of Antimicrobial Chemotherapy, 72 [Details]
(2016) 'A unique SaeS allele overrides cell-density dependent expression of saeR and lukSF-PV in the ST30-SCCmecIV lineage of CA-MRSA'
Ramundo MS, Beltrame CO, Botelho AM, Coelho LR, Silva-Carvalho MC, Ferreira-Carvalho BT, Nicolás MF, Guedes IA, Dardenne LE, O'Gara J, Figueiredo AM. (2016) 'A unique SaeS allele overrides cell-density dependent expression of saeR and lukSF-PV in the ST30-SCCmecIV lineage of CA-MRSA'. International Journal Of Medical Microbiology, 306 [DOI] [Details]
(2016) 'The major autolysin is redundant for Staphylococcus aureus USA300 LAC JE2 virulence in a murine device-related infection model'
McCarthy H, Waters EM, Bose JL, Foster S, Bayles KW, O'Neill E, Fey PD, O'Gara JP. (2016) 'The major autolysin is redundant for Staphylococcus aureus USA300 LAC JE2 virulence in a murine device-related infection model'. Fems Microbiology Letters, 363 [DOI] [Details]
(2016) 'AraC-type regulator Rbf controls the Staphylococcus epidermidis biofilm phenotype by negatively regulating the icaADBC repressor SarR'
Rowe SE, Campbell C, Lowry C, O'Donnell ST, Olson ME, Lindgren JK, Waters EM, Fey PD, O'Gara JP. (2016) 'AraC-type regulator Rbf controls the Staphylococcus epidermidis biofilm phenotype by negatively regulating the icaADBC repressor SarR'. Journal Of Bacteriology, 198 [DOI] [Details]
(2016) 'Convergence of Staphylococcus aureus Persister and Biofilm Research: Can Biofilms Be Defined as Communities of Adherent Persister Cells?'
Waters EM, Rowe SE, O'Gara JP, Conlon BP. (2016) 'Convergence of Staphylococcus aureus Persister and Biofilm Research: Can Biofilms Be Defined as Communities of Adherent Persister Cells?'. Plos Pathogens, 12 [DOI] [Details]
(2016) 'In Vitro Approach for Identification of the Most Effective Agents for Antimicrobial Lock Therapy in the Treatment of Intravascular Catheter-Related Infections Caused by Staphylococcus aureus'
Hogan S, Zapotoczna M, Stevens NT, Humphreys H, O'Gara JP, O'Neill E. (2016) 'In Vitro Approach for Identification of the Most Effective Agents for Antimicrobial Lock Therapy in the Treatment of Intravascular Catheter-Related Infections Caused by Staphylococcus aureus'. Antimicrobial Agents And Chemotherapy, 60 [DOI] [Details]
(2016) 'Eradication of Staphylococcus aureus catheter-related biofilm infections using ML:8 and Citrox'
Hogan S, Zapotoczna M, Stevens N, Humphreys H, O'Gara JP, O'Neill E. (2016) 'Eradication of Staphylococcus aureus catheter-related biofilm infections using ML:8 and Citrox'. Antimicrobial Agents And Chemotherapy, 60 [Details]
(2016) 'Untangling the diverse and redundant mechanisms of Staphylococcus aureus biofilm formation'
Zapotoczna M, O’Neill E, O'Gara JP (2016) 'Untangling the diverse and redundant mechanisms of Staphylococcus aureus biofilm formation'. Plos Pathogens, 12 [Details]
(2016) 'Electrophoretic Mobility Shift Assays'
Rowe SE, O'Gara JP. (2016) 'Electrophoretic Mobility Shift Assays'. Methods in molecular biology (Clifton, N.J.), 1373 [DOI] [Details]
(2016) 'The Possible Role of Staphylococcus epidermidis LPxTG Surface Protein SesC in Biofilm Formation'
Khodaparast L, Shahrooei M, Stijlemans B, Merckx R, Baatsen P, O'Gara JP, Waters E, Van Mellaert L, Van Eldere J. (2016) 'The Possible Role of Staphylococcus epidermidis LPxTG Surface Protein SesC in Biofilm Formation'. Plos One, 11 [DOI] [Details]
(2015) 'Methicillin resistance and the biofilm phenotype in Staphylococcus aureus'
McCarthy H, Rudkin JK, Black NS, Gallagher L, O'Neill E, O'Gara JP. (2015) 'Methicillin resistance and the biofilm phenotype in Staphylococcus aureus'. Frontiers In Cellular And Infection Microbiology, 5 [DOI] [Details]
(2015) 'An essential role for coagulase in Staphylococcus aureus biofilm development reveals new therapeutic possibilities for device-related infections'
Zapotoczna M, McCarthy H, Rudkin JK, O’Gara JP, O’Neill E. (2015) 'An essential role for coagulase in Staphylococcus aureus biofilm development reveals new therapeutic possibilities for device-related infections'. Journal Of Infectious Diseases, 212 [Details]
(2015) 'Recombination-mediated remodelling of host–pathogen interactions during Staphylococcus aureus niche adaptation'
Spoor LE, Richardson E, Richards AC, Wilson GJ, Mendonca C, Gupta RK, McAdam PR, Nutbeam-Tuffs S, Black NS, O'Gara JP, Lee CY, Corander J, Fitzgerald JR. (2015) 'Recombination-mediated remodelling of host–pathogen interactions during Staphylococcus aureus niche adaptation'. Microbial Genomics, 1 [Details]
(2014) 'Fibronectin-binding proteins are required for biofilm formation by community-associated methicillin- resistant Staphylococcus aureus strain LAC'
McCourt J, O'Halloran DP, McCarthy H, O'Gara JP, Geoghegan JA. (2014) 'Fibronectin-binding proteins are required for biofilm formation by community-associated methicillin- resistant Staphylococcus aureus strain LAC'. Fems Microbiology Letters, 353 [DOI] [Details]
(2014) 'Rapid Quantitative and Qualitative Analysis of Biofilm Production by Staphylococcus epidermidis under Static Growth Conditions'
Waters EM, McCarthy H, Hogan S, Zapotoczna M, O’Neill E, O’Gara JP. (2014) 'Rapid Quantitative and Qualitative Analysis of Biofilm Production by Staphylococcus epidermidis under Static Growth Conditions'. Methods Mol Biol, 1106 [DOI] [Details]
(2014) 'Role for the A domain of unprocessed accumulation-associated protein (Aap) in the attachment phase of the Staphylococcus epidermidis biofilm phenotype'
Conlon BP, Geoghegan JA, Waters EM, McCarthy H, Rowe SE, Davies JR, Schaeffer CR, Foster TJ, Fey PD, O'Gara JP. (2014) 'Role for the A domain of unprocessed accumulation-associated protein (Aap) in the attachment phase of the Staphylococcus epidermidis biofilm phenotype'. Journal Of Bacteriology, 196 [DOI] [Details]
(2014) 'Oxacillin Alters the Toxin Expression Profile of Community-Associated Methicillin-Resistant Staphylococcus aureus'
Rudkin JK, Laabei M, Edwards AM, Joo HS, Otto M, Lennon KL, O'Gara JP, Waterfield NR, Massey RC. (2014) 'Oxacillin Alters the Toxin Expression Profile of Community-Associated Methicillin-Resistant Staphylococcus aureus'. Antimicrobial Agents And Chemotherapy, 58 [DOI] [Details]
(2014) 'Current and Future Approaches to the Prevention and Treatment of Staphylococcal Medical Device-Related Infections'
Hogan S, Stevens NT, Humphreys H, O'Gara JP, O'Neill E. (2014) 'Current and Future Approaches to the Prevention and Treatment of Staphylococcal Medical Device-Related Infections'. Current Pharmaceutical Design, 21 [Details]
(2013) 'Subdomains N2N3 of Fibronectin Binding Protein A Mediate Staphylococcus aureus Biofilm Formation and Adherence to Fibrinogen Using Distinct Mechanisms'
Geoghegan JA, Monk IR, O'Gara JP, Foster TJ. (2013) 'Subdomains N2N3 of Fibronectin Binding Protein A Mediate Staphylococcus aureus Biofilm Formation and Adherence to Fibrinogen Using Distinct Mechanisms'. Journal Of Bacteriology, 195 [DOI] [Details]
(2012) 'Methicillin Resistance Alters the Biofilm Phenotype and Attenuates Virulence in Staphylococcus aureus Device-Associated Infections'
Pozzi C, Waters EM, Rudkin JK, Schaeffer CR, Lohan AJ, Tong P, Loftus BJ, Pier GB, Fey PD, Massey RC, O'Gara JP. (2012) 'Methicillin Resistance Alters the Biofilm Phenotype and Attenuates Virulence in Staphylococcus aureus Device-Associated Infections'. Plos Pathogens, 8 [DOI] [Details]
(2012) 'Ventriculoperitoneal shunt-related infections caused by Staphylococcus epidermidis: pathogenesis and implications for treatment'
Stevens NT, Greene CM, O'Gara JP, Bayston R, Sattar MTA, Farrell M, Humphreys H. (2012) 'Ventriculoperitoneal shunt-related infections caused by Staphylococcus epidermidis: pathogenesis and implications for treatment'. British Journal Of Neurosurgery, 26 :792-797 [DOI] [Details]
(2012) 'Investigations into the Antibacterial Activity of the Silver-Based Antibiotic Drug Candidate SBC3'
Sharkey MA, O'Gara JP, Gordon SV, Hackenberg F, Healy C, Paradisi F, Patil S, Schaible B, Tacke M. (2012) 'Investigations into the Antibacterial Activity of the Silver-Based Antibiotic Drug Candidate SBC3'. Journal Of Antibiotics, 1 :25-28 [Details]
(2012) 'Methicillin resistance reduces the virulence of healthcare-associated methicillin-resistant Staphylococcus aureus by interfering with the agr quorum sensing system'
Rudkin JK, Edwards AM, Bowden MG, Brown EL, Pozzi C, Waters EM, Chan WC, Williams P, O'Gara JP, Massey RC (2012) 'Methicillin resistance reduces the virulence of healthcare-associated methicillin-resistant Staphylococcus aureus by interfering with the agr quorum sensing system'. Journal Of Infectious Diseases, 205 :798-806 [DOI] [Details]
(2012) 'Evaluation of vaporized hydrogen peroxide, Citrox and pH neutral Ecasol for decontamination of an enclosed area: a pilot study'
Galvin S, Boyle M, Russell RJ, Coleman DC, Creamer E, O'Gara JP, Fitzgerald-Hughes D, Humphreys H (2012) 'Evaluation of vaporized hydrogen peroxide, Citrox and pH neutral Ecasol for decontamination of an enclosed area: a pilot study'. J Hosp Infect, 80 [DOI] [Details]
(2012) 'Evaluation of protein adsorption on atmospheric plasma deposited coatings exhibiting superhydrophilic to superhydrophobic properties'
Stallard CP, McDonnell KA, Onayemi OD, O'Gara JP, Dowling DP (2012) 'Evaluation of protein adsorption on atmospheric plasma deposited coatings exhibiting superhydrophilic to superhydrophobic properties'. Biointerphases, 7 [DOI] [Details]
(2011) 'A novel role for SarX in Staphylococcus epidermidis biofilm regulation'
Rowe SE, Mahon V, Smith SG, O'Gara JP. (2011) 'A novel role for SarX in Staphylococcus epidermidis biofilm regulation'. Microbiology, 157 :1042-1049 [DOI] [Details]
(2011) 'Essential role for the major autolysin in the fibronectin-binding protein-mediated Staphylococcus aureus biofilm phenotype'
Houston P, Rowe SE, Pozzi C, Waters EM, O'Gara JP (2011) 'Essential role for the major autolysin in the fibronectin-binding protein-mediated Staphylococcus aureus biofilm phenotype'. Infection And Immunity, 79 :1153-1165 [DOI] [Details]
(2011) 'Mutation of tagO reveals an essential role for wall teichoic acids in Staphylococcus epidermidis biofilm development'
Holland LM, Conlon B, O'Gara JP. (2011) 'Mutation of tagO reveals an essential role for wall teichoic acids in Staphylococcus epidermidis biofilm development'. Microbiology, 157 :408-418 [DOI] [Details]
(2011) 'Disinfection of meticillin-resistant Staphylococcus aureus and Staphylococcus epidermidis biofilms using a remote non-thermal gas plasma'
Cotter JJ, Maguire P, Soberon F, Daniels S, O'Gara JP, Casey E (2011) 'Disinfection of meticillin-resistant Staphylococcus aureus and Staphylococcus epidermidis biofilms using a remote non-thermal gas plasma'. J Hosp Infect, 78 :204-207 [DOI] [Details]
(2011) 'Resistance of Staphylococcus aureus to the cationic antimicrobial agent poly(2-(dimethylamino ethyl)methacrylate) (pDMAEMA) is influenced by cell-surface charge and hydrophobicity'
Rawlinson LA, O'Gara JP, Jones DS, Brayden DJ (2011) 'Resistance of Staphylococcus aureus to the cationic antimicrobial agent poly(2-(dimethylamino ethyl)methacrylate) (pDMAEMA) is influenced by cell-surface charge and hydrophobicity'. Journal Of Medical Microbiology, 60 (Pt 7):968-976 [DOI] [Details]
(2010) 'Role of surface protein SasG in biofilm formation by Staphylococcus aureus'
Geoghegan JA, Corrigan RM, Gruszka DT, Speziale P, O'Gara JP, Potts JR, Foster TJ (2010) 'Role of surface protein SasG in biofilm formation by Staphylococcus aureus'. Journal Of Bacteriology, 192 (21):5663-5673 [DOI] [Details]
(2010) 'Offsetting virulence and antibiotic resistance costs by MRSA'
Collins J, Rudkin J, Recker M, Pozzi C, O'Gara JP, Massey RC (2010) 'Offsetting virulence and antibiotic resistance costs by MRSA'. The ISME journal, 4 (4):577-584 [DOI] [Details]
(2010) 'Anti-biofilm activity of sub-inhibitory povidone-iodine concentrations against Staphylococcus epidermidis and Staphylococcus aureus'
Oduwole KO, Glynn AA, Molony DC, Murray D, Rowe S, Holland LM, McCormack DJ, O'Gara JP (2010) 'Anti-biofilm activity of sub-inhibitory povidone-iodine concentrations against Staphylococcus epidermidis and Staphylococcus aureus'. Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 28 (9):1252-1256 [DOI] [Details]
(2010) 'Characterization of a modified rotating disk reactor for the cultivation of Staphylococcus epidermidis biofilm'
Cotter JJ, O'Gara JP, Stewart PS, Pitts B, Casey E (2010) 'Characterization of a modified rotating disk reactor for the cultivation of Staphylococcus epidermidis biofilm'. Journal Of Applied Microbiology, 109 (6):2105-2117 [DOI] [Details]
(2009) 'Hydrogen peroxide induced repression of icaADBC transcription and biofilm development in Staphylococcus epidermidis'
Glynn AA, O'Donnell ST, Molony DC, Sheehan E, McCormack DJ, O'Gara JP (2009) 'Hydrogen peroxide induced repression of icaADBC transcription and biofilm development in Staphylococcus epidermidis'. Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 27 (5):627-630 [DOI] [Details]
(2009) 'Oxygen-mediated regulation of biofilm development is controlled by the alternative sigma factor sigma(B) in Staphylococcus epidermidis'
Cotter JJ, O'Gara JP, Mack D, Casey E (2009) 'Oxygen-mediated regulation of biofilm development is controlled by the alternative sigma factor sigma(B) in Staphylococcus epidermidis'. Applied And Environmental Microbiology, 75 (1):261-264 [DOI] [Details]
(2009) 'Staphylococcus epidermidis polysaccharide intercellular adhesin induces IL-8 expression in human astrocytes via a mechanism involving TLR2'
Stevens NT, Sadovskaya I, Jabbouri S, Sattar T, O'Gara JP, Humphreys H, Greene CM (2009) 'Staphylococcus epidermidis polysaccharide intercellular adhesin induces IL-8 expression in human astrocytes via a mechanism involving TLR2'. Cellular Microbiology, 11 (3):421-432 [DOI] [Details]
(2009) 'Carriage of both the fnbA and fnbB genes and growth at 37 degrees C promote FnBP-mediated biofilm development in meticillin-resistant Staphylococcus aureus clinical isolates'
O'Neill E, Humphreys H, O'Gara JP (2009) 'Carriage of both the fnbA and fnbB genes and growth at 37 degrees C promote FnBP-mediated biofilm development in meticillin-resistant Staphylococcus aureus clinical isolates'. Journal Of Medical Microbiology, 58 (Pt 4):399-402 [DOI] [Details]
(2009) 'Rapid depletion of dissolved oxygen in 96-well microtiter plate Staphylococcus epidermidis biofilm assays promotes biofilm development and is influenced by inoculum cell concentration'
Cotter JJ, O'Gara JP, Casey E (2009) 'Rapid depletion of dissolved oxygen in 96-well microtiter plate Staphylococcus epidermidis biofilm assays promotes biofilm development and is influenced by inoculum cell concentration'. Biotechnology and Bioengineering, 103 (5):1042-1047 [DOI] [Details]
(2009) 'Biofilm characteristics of Staphylococcus epidermidis isolates associated with device-related meningitis'
Stevens NT, Greene CM, O'Gara JP, Humphreys H (2009) 'Biofilm characteristics of Staphylococcus epidermidis isolates associated with device-related meningitis'. Journal Of Medical Microbiology, 58 (Pt 7):855-862 [DOI] [Details]
(2009) 'Rbf promotes biofilm formation by Staphylococcus aureus via repression of icaR, a negative regulator of icaADBC'
Cue D, Lei MG, Luong TT, Kuechenmeister L, Dunman PM, O'Donnell S, Rowe S, O'Gara JP, Lee CY (2009) 'Rbf promotes biofilm formation by Staphylococcus aureus via repression of icaR, a negative regulator of icaADBC'. Journal Of Bacteriology, 191 (20):6363-6373 [DOI] [Details]
(2008) 'A novel Staphylococcus aureus biofilm phenotype mediated by the fibronectin-binding proteins, FnBPA and FnBPB'
O'Neill E, Pozzi C, Houston P, Humphreys H, Robinson DA, Loughman A, Foster TJ, O'Gara JP (2008) 'A novel Staphylococcus aureus biofilm phenotype mediated by the fibronectin-binding proteins, FnBPA and FnBPB'. Journal Of Bacteriology, 190 (11):3835-3850 [DOI] [Details]
(2008) 'A staphylococcal GGDEF domain protein regulates biofilm formation independently of cyclic dimeric GMP'
Holland LM, O'Donnell ST, Ryjenkov DA, Gomelsky L, Slater SR, Fey PD, Gomelsky M, O'Gara JP (2008) 'A staphylococcal GGDEF domain protein regulates biofilm formation independently of cyclic dimeric GMP'. Journal Of Bacteriology, 190 (15):5178-5189 [DOI] [Details]
(2008) 'Biofilm and the role of the ica operon and aap in Staphylococcus epidermidis isolates causing neurosurgical meningitis'
Stevens NT, Tharmabala M, Dillane T, Greene CM, O'Gara JP, Humphreys H (2008) 'Biofilm and the role of the ica operon and aap in Staphylococcus epidermidis isolates causing neurosurgical meningitis'. Clin Microbiol Infect, 14 (7):719-722 [DOI] [Details]
(2007) 'ica and beyond: biofilm mechanisms and regulation in Staphylococcus epidermidis and Staphylococcus aureus'
O'Gara JP (2007) 'ica and beyond: biofilm mechanisms and regulation in Staphylococcus epidermidis and Staphylococcus aureus'. Fems Microbiology Letters, 270 (2):179-188 [DOI] [Details]
(2007) 'Association between methicillin susceptibility and biofilm regulation in Staphylococcus aureus isolates from device-related infections'
O'Neill E, Pozzi C, Houston P, Smyth D, Humphreys H, Robinson DA, O'Gara JP (2007) 'Association between methicillin susceptibility and biofilm regulation in Staphylococcus aureus isolates from device-related infections'. Journal Of Clinical Microbiology, 45 (5):1379-1388 [DOI] [Details]
(2007) 'SigmaB and SarA independently regulate polysaccharide intercellular adhesin production in Staphylococcus epidermidis'
Handke LD, Slater SR, Conlon KM, O'Donnell ST, Olson ME, Bryant KA, Rupp ME, O'Gara JP, Fey PD (2007) 'SigmaB and SarA independently regulate polysaccharide intercellular adhesin production in Staphylococcus epidermidis'. Canadian Journal Of Microbiology, 53 (1):82-91 [DOI] [Details]
(2006) 'Environmental regulation of biofilm development in methicillin-resistant and methicillin-susceptible Staphylococcus aureus clinical isolates'
Fitzpatrick F, Humphreys H, O'Gara JP (2006) 'Environmental regulation of biofilm development in methicillin-resistant and methicillin-susceptible Staphylococcus aureus clinical isolates'. J Hosp Infect, 62 (1):120-122 [DOI] [Details]
(2005) 'The genetics of staphylococcal biofilm formation--will a greater understanding of pathogenesis lead to better management of device-related infection?'
Fitzpatrick F, Humphreys H, O'Gara JP (2005) 'The genetics of staphylococcal biofilm formation--will a greater understanding of pathogenesis lead to better management of device-related infection?'. Clin Microbiol Infect, 11 (12):967-973 [DOI] [Details]
(2005) 'The genetics of staphylococcal biofilm formation-will a greater understanding of pathogenesis lead to better management of device-related infection?'
Fitzpatrick F, Humphreys H, O'Gara JP. (2005) 'The genetics of staphylococcal biofilm formation-will a greater understanding of pathogenesis lead to better management of device-related infection?'. Clinical Microbiology And Infection, 11 :967-973 [DOI] [Details]
(2005) 'Evidence for icaADBC-independent biofilm development mechanism in methicillin-resistant Staphylococcus aureus clinical isolates'
Fitzpatrick F, Humphreys H, O'Gara JP (2005) 'Evidence for icaADBC-independent biofilm development mechanism in methicillin-resistant Staphylococcus aureus clinical isolates'. Journal Of Clinical Microbiology, 43 (4):1973-1976 [DOI] [Details]
(2005) 'Evidence for low temperature regulation of biofilm formation in Staphylococcus epidermidis'
Fitzpatrick F, Humphreys H, O'Gara JP. (2005) 'Evidence for low temperature regulation of biofilm formation in Staphylococcus epidermidis'. Journal Of Medical Microbiology, 54 :509-510 [DOI] [Details]
(2005) 'Genomic diversity of Staphylococcus epidermidis isolates from the intensive care unit'
FitzGerald SF, Fitzpatrick F, Dillane T, Smith EG, Humphreys H, O'Gara JP (2005) 'Genomic diversity of Staphylococcus epidermidis isolates from the intensive care unit'. Clin Microbiol Infect, 11 (7) [DOI] [Details]
(2004) 'Contribution of culture media and chemical properties of polystyrene tissue culture plates to biofilm development by Staphylococcus aureus'
Kennedy CA, O'Gara JP (2004) 'Contribution of culture media and chemical properties of polystyrene tissue culture plates to biofilm development by Staphylococcus aureus'. Journal Of Medical Microbiology, 53 (Pt 11):1171-1173 [Details]
(2004) 'Inactivations of rsbU and sarA by IS256 represent novel mechanisms of biofilm phenotypic variation in Staphylococcus epidermidis'
Conlon KM, Humphreys H, O'Gara JP (2004) 'Inactivations of rsbU and sarA by IS256 represent novel mechanisms of biofilm phenotypic variation in Staphylococcus epidermidis'. Journal Of Bacteriology, 186 (18):6208-6219 [DOI] [Details]
(2004) 'Genetic and phenotypic analysis of biofilm phenotypic variation in multiple Staphylococcus epidermidis isolates'
Handke LD, Conlon KM, Slater SR, Elbaruni S, Fitzpatrick F, Humphreys H, Giles WP, Rupp ME, Fey PD, O'Gara JP (2004) 'Genetic and phenotypic analysis of biofilm phenotypic variation in multiple Staphylococcus epidermidis isolates'. Journal Of Medical Microbiology, 53 (Pt 5):367-374 [Details]
(2002) 'Regulation of icaR gene expression in Staphylococcus epidermidis'
Conlon KM, Humphreys H, O'Gara JP (2002) 'Regulation of icaR gene expression in Staphylococcus epidermidis'. Fems Microbiology Letters, 216 (2):171-177 [Details]
(2002) 'Environmental regulation of biofilm formation in intensive care unit isolates of Staphylococcus epidermidis'
Fitzpatrick F, Humphreys H, Smyth E, Kennedy CA, O'Gara JP (2002) 'Environmental regulation of biofilm formation in intensive care unit isolates of Staphylococcus epidermidis'. J Hosp Infect, 52 (3):212-218 [Details]
(2002) 'icaR encodes a transcriptional repressor involved in environmental regulation of ica operon expression and biofilm formation in Staphylococcus epidermidis'
Conlon KM, Humphreys H, O'Gara JP (2002) 'icaR encodes a transcriptional repressor involved in environmental regulation of ica operon expression and biofilm formation in Staphylococcus epidermidis'. Journal Of Bacteriology, 184 (16):4400-4408 [Details]
(2001) 'Staphylococcus epidermidis biofilms: importance and implications'
O'Gara JP, Humphreys H (2001) 'Staphylococcus epidermidis biofilms: importance and implications'. Journal Of Medical Microbiology, 50 (7):582-587 [Details]
(2000) 'Effects of local transcription and H-NS on inversion of the fim switch of Escherichia coli'
O'Gara JP, Dorman CJ (2000) 'Effects of local transcription and H-NS on inversion of the fim switch of Escherichia coli'. Molecular Microbiology, 36 (2):457-466 [Details]
(1998) 'Control of photosystem formation in Rhodobacter sphaeroides'
Zeilstra-Ryalls J, Gomelsky M, Eraso JM, Yeliseev A, O'Gara J, Kaplan S. (1998) 'Control of photosystem formation in Rhodobacter sphaeroides'. Journal Of Bacteriology, 180 :2801-2809 [Details]
(1998) 'A redox-responsive pathway for aerobic regulation of photosynthesis gene expression in Rhodobacter sphaeroides 2.4.1'
O'Gara JP, Eraso JM, Kaplan S (1998) 'A redox-responsive pathway for aerobic regulation of photosynthesis gene expression in Rhodobacter sphaeroides 2.4.1'. Journal Of Bacteriology, 180 (16):4044-4050 [Details]
(1997) 'Evidence for the role of redox carriers in photosynthesis gene expression and carotenoid biosynthesis in Rhodobacter sphaeroides 2.4.1'
O'Gara JP, Kaplan S (1997) 'Evidence for the role of redox carriers in photosynthesis gene expression and carotenoid biosynthesis in Rhodobacter sphaeroides 2.4.1'. Journal Of Bacteriology, 179 (6):1951-1961 [Details]
(1997) 'Identification and molecular genetic analysis of multiple loci contributing to high-level tellurite resistance in Rhodobacter sphaeroides 2.4.1'
O'Gara JP, Gomelsky M, Kaplan S (1997) 'Identification and molecular genetic analysis of multiple loci contributing to high-level tellurite resistance in Rhodobacter sphaeroides 2.4.1'. Applied And Environmental Microbiology, 63 (12):4713-4720 [Details]
(1995) 'Mutations in the trpD gene of Corynebacterium glutamicum confer 5-methyltryptophan resistance by encoding a feedback-resistant anthranilate phosphoribosyltransferase'
O'Gara JP, Dunican LK (1995) 'Mutations in the trpD gene of Corynebacterium glutamicum confer 5-methyltryptophan resistance by encoding a feedback-resistant anthranilate phosphoribosyltransferase'. Applied And Environmental Microbiology, 61 (12):4477-4479 [Details]
(1994) 'Direct evidence for a constitutive internal promoter in the tryptophan operon of Corynebacterium glutamicum'
O'Gara JP, Dunican LK (1994) 'Direct evidence for a constitutive internal promoter in the tryptophan operon of Corynebacterium glutamicum'. Biochem Biophy Res Commun, 203 :820-827 [Details]

Research Paper

  Year Publication
(2021) Mutation of lipoprotein processing pathway gene lspA or inhibition of LspA activity by globomycin increases MRSA resistance to beta-lactam antibiotics.
Fingleton C, Zeden MS, Bueno E, Cava F, O’Gara JP. (2021) Mutation of lipoprotein processing pathway gene lspA or inhibition of LspA activity by globomycin increases MRSA resistance to beta-lactam antibiotics. Cold Spring Harbour Laboratory: bioRxiv Research Paper [Details]

Other Journals

  Year Publication
(2021) 'A scoping review protocol to identify clinical signs, symptoms and biomarkers indicative of biofilm presence in chronic wounds'
Ivory JD, Vellinga A, O'Gara J, Gethin G. (2021) 'A scoping review protocol to identify clinical signs, symptoms and biomarkers indicative of biofilm presence in chronic wounds' HRB Open Research, 4 . [Details]

Conference Contributions

  Year Publication
(2023) Gordon Research Conference on Staphylococci and Staphylococcal Infections,
Zeden MS, Gallagher LA, Bueno E, Nolan A, Ahm J, Shinde D, Razvi F, Sladek M, Burke O, O'Neill E, Fey PD, Cava F, Thomas VC, O'Gara JP (2023) Manipulation of purine homeostasis to exploit an Achilles heel in MRSA beta-lactam resistance. [International Refereed Conference], Gordon Research Conference on Staphylococci and Staphylococcal Infections, Waterville Valley, NH, United States , 30-JUL-23 - 04-AUG-23. [Details]
(2023) Staphylococcus Great Britain and Ireland Conference 2023,
James P. O'Gara, Merve S Zeden (2023) Staphylococcus Great Britain and Ireland Conference 2023. [Conference Organising Committee Chairperson], Staphylococcus Great Britain and Ireland Conference 2023, University of Galway , 22-JUN-23 - 23-FEB-24. [Details]
(2023) Staphylococcal Diseases Gordon Research Seminar,
Merve S. Zeden, Laura A. Gallagher, Emilio Bueno, Aaron C. Nolan, Jongsam Ahn, Dhananjay Shinde, Fareha Razvi, Margaret Sladek, Orla Burke, Eoghan O'Neill, Paul D. Fey, Felipe Cava, Vinai C. Thomas and James P. O'Gara (2023) Metabolic reprogramming and altered cell envelope characteristics in a pentose phosphate pathway mutant increases MRSA resistance to beta-lactam antibiotics. [International Refereed Conference], Staphylococcal Diseases Gordon Research Seminar, Waterville Valley, NH, United States , 29-JUL-23 - 30-JUL-23. [Details]
(2023) StaphGBI 2023,
Roy R, Zeden MS, O'Gara JP (2023) An S180F mutation in D-alanine aminotransferase confers resistance to ß-Chloro-D-alanine in Staphylococcus aureus. [Published Abstract], StaphGBI 2023, Galway, Ireland , 22-JUN-23 - 23-JUN-23. [Details]
(2023) StaphGBI 2023,
Chloe Hobbs, Leanne Diviney, Teck Wee Boo, David Gallagher, Georgina Gethin and James P. O'Gara (2023) Therapeutic potential of rifampicin-Proteinase K combinations against protein adhesin biofilms produced by Staphylococcus aureus diabetic foot infection isolates. [International Refereed Conference], StaphGBI 2023, Galway, Ireland , 22-JUN-23 - 23-JUN-23. [Details]
(2023) StaphGBI 2023,
Shahrour H., Ferreira D.A., Devocelle M., O'Gara J.P., Kelly H, Fitzgerald-Hughes D. and O'Neill E. (2023) Antibiofilm activity of novel agents against Staphylococcus aureus and Pseudomonas aeruginosa co-infection wound model. [International Refereed Conference], StaphGBI 2023, Galway, Ireland , 22-JUN-23 - 23-JUN-23. [Details]
(2023) StaphGBI 2023,
Nolan, A.C., Zeden, M.Z., Kviatkovski, I., Campbell, C., Irwin, L., Corrigan, R.M., Gründling, A., O'Gara, J.P. (2023) Purine Homeostasis is essential for maintenance of beta-lactam resistance. [International Refereed Conference], StaphGBI 2023, Galway, Ireland , 22-JUN-23 - 23-JUN-23. [Details]
(2023) StaphGBI 2023,
Merve S. Zeden, Laura A. Gallagher, Emilio Bueno, Aaron C. Nolan, Jongsam Ahn, Dhananjay Shinde, Fareha Razvi, Margaret Sladek, Órla Burke, Eoghan O'Neill, Paul D. Fey, Felipe Cava, Vinai C. Thomas and James P. O'Gara (2023) Metabolic reprogramming and altered cell envelope characteristics in a pentose phosphate pathway mutant increases MRSA resistance to beta-lactam antibiotics. [International Refereed Conference], StaphGBI 2023, Galway, Ireland , 22-JUN-23 - 23-JUN-23. [Details]
(2023) Staphylococcus Great Britain and Ireland 2023,
O'Gara JP (2023) Ireland and the UK conference focused on staphylococci and staphylococcal infections. [Conference Organising Committee Chairperson], Staphylococcus Great Britain and Ireland 2023, Galway, Ireland , 22-JUN-23 - 23-JUN-23. [Details]
(2023) StaphGBI 2023,
Burke, Ó., Singh, R., Thomas, V.C., Zeden, M.S., O'Gara, J.P. (2023) Investigating the role of the cryptic AdpS protein in Staphylococcus epidermidis physiology. [International Refereed Conference], StaphGBI 2023, Galway, Ireland , 22-JUN-23 - 23-JUN-23. [Details]
(2023) 33rd European Wound Management Association Conference,
Hobbs C, Wee Boo T, Gallagher D, Diviney L, Gethin G, O'Gara JP (2023) Therapeutic potential of Rifampicin-Proteinase K combinations against protein adhesin biofilms produced by Staphylococcus aureus Diabetic Foot Infection isolates. [Published Abstract], 33rd European Wound Management Association Conference, Milan, Italy , 03-MAY-23 - 05-MAY-23. [Details]
(2018) International Symposium on Staphylococci and Staphylococcal Infections,
Laura A. Gallagher, Elaine M. Waters, Claire Fingleton, Binayak Rimal, Christopher Campbell, Laura Bricio-Moreno, Akhilesh K. Yadav, Felipe Cava, Fareha Razvi, Eoghan O'Neill, Aras Kadioglu, Alex J. O'Neill, Sung Joon Kim, Paul D. Fey and James P. O'Gara (2018) An alanine permease mutation alters peptidoglycan structure leading to decreased beta-lactam resistance in MRSA. [International Refereed Conference], International Symposium on Staphylococci and Staphylococcal Infections, Copenhagen, Denmark , 23-AUG-18 - 26-AUG-18. [Details]
(2018) International Symposium on Staphylococci and Staphylococcal Infections,
Chris Campbell, Laura Gallagher and James P. O'Gara (2018) Mutation of succinyl-CoA synthetase in the TCA cycle decreases beta-lactam resistance in MRSA. [International Refereed Conference], International Symposium on Staphylococci and Staphylococcal Infections, Copenhagen, Denmark , 23-AUG-18 - 26-AUG-18. [Details]
(2017) Gordon Research Conference on Staphylococci and Staphylococcal Infections,
Elaine M. Waters, Geremy C. Clair, Jenny Clarke, Justine K. Rudkin, Joshua N. Adkins, Aras Kadioglu, James P. O'Gara (2017) Redeploying beta-Lactam Antibiotics as a Novel Anti-Virulence and Anti-Persister Strategy for the Treatment of MRSA Infections. [International Refereed Conference], Gordon Research Conference on Staphylococci and Staphylococcal Infections, Waterville Valley, NH, United States , 06-AUG-17 - 11-AUG-17. [Details]
(2016) International Symposium on Staphylococci and Staphylococcal Infections,
Elaine M .Waters, Justine K. Rudkin, Simone Coughlan, Suzanna Gore, Guoqing Xia, Nikki S. Black, Tim Downing, Eoghan O'Neill, Aras Kadioglu, James P O'Gara (2016) REDEPLOYING ¿ETA-LACTAM ANTIBIOTICS AS A NOVEL ANTI-VIRULENCE STRATEGY FOR THE TREATMENT OF MRSA INFECTIONS. [International Refereed Conference], International Symposium on Staphylococci and Staphylococcal Infections, Soeul, South Korea , 30-AUG-16 - 02-SEP-16. [Details]
(2016) 3rd International Conference on the Pathophysiology of Staphylococci,
O'Gara JP (2016) Session Chair: The other staphs - CoNS and beyond. [Chaired Session], 3rd International Conference on the Pathophysiology of Staphylococci, Tubingen, Germany , 15-SEP-16 - 17-SEP-16. [Details]
(2015) Microbial Interfaces,
O'Gara JP (2015) Society for General Microbiology Irish Division meeting. Organised to coincide with the 50th Anniversary of Microbiology at NUI Galway. [Chaired Session], Microbial Interfaces, Galway, Ireland , 17-JUN-15 - 19-JUN-15. [Details]
(2015) Microbial Interfaces,
O'Gara JP (2015) Society for General Microbiology Irish Division meeting. Organised to coincide with the 50th Anniversary of Microbiology at NUI Galway. [Conference Organising Committee Member], Microbial Interfaces, Galway, Ireland , 17-JUN-15 - 19-JUN-15. [Details]
(2015) Gordon Research Conference on Staphylococci and Staphylococcal Infections,
Marta Zapotoczna, Hannah McCarthy, Justine Rudkin, Eoghan O'Neill, and James P. O'Gara (2015) Novel roles for SaeRS, coagulase and clumping factor A (ClfA) in Staphylococcus aureus biofilm development reveal new therapeutic possibilities for device-related infections. [International Refereed Conference], Gordon Research Conference on Staphylococci and Staphylococcal Infections, Italy , 12-JUL-15 - 17-JUL-15. [Details]
(2014) International Symposium on Staphylococci and Staphylococcal Infections,
Marta Zapotoczna, Eanna Forde, Mark Devocelle, Deirdre Fitzgerald-Hughes, James P. O'Gara, Hilary Humphreys & Eoghan O'Neill (2014) Antimicrobial peptides kill Staphylococcus aureus biofilms. [International Refereed Conference], International Symposium on Staphylococci and Staphylococcal Infections, Chicago, IL, USA , 26-AUG-14 - 29-AUG-14. [Details]
(2014) International Symposium on Staphylococci and Staphylococcal Infections,
Elaine M. Waters, S Gore, JK Rudkin, A Kadioglu, JP O'Gara (2014) Attenuation of MRSA virulence by oxacillin. [International Refereed Conference], International Symposium on Staphylococci and Staphylococcal Infections, Chicago, IL, USA , 26-AUG-14 - 29-AUG-14. [Details]
(2014) International Symposium on Staphylococci and Staphylococcal Infections,
S. Hogan, M. Zapotoczna, N.T. Stevens, H. Humphreys, J.P O'Gara, E. O'Neill (2014) Impact of Novel Antimicrobials on Staphylococcal Biofilm. [International Refereed Conference], International Symposium on Staphylococci and Staphylococcal Infections, Chicago, IL, USA , 26-AUG-14 - 29-AUG-14. [Details]
(2014) International Symposium on Staphylococci and Staphylococcal Infections,
Hannah E. McCarthy, Elaine M. Waters, Sarah E. Rowe, Carolyn R. Schaeffer, Marta Zapotoczna, Joan A. Geoghegan, Jeffrey L. Bose, Kenneth W. Bayles, Simon J. Foster, Eoghan O'Neill, Paul D. Fey and James P. O'Gara (2014) Evidence of a role for the major autolysin in Staphylococcus aureus biofilm formation under in vitro but not in vivo conditions. [International Refereed Conference], International Symposium on Staphylococci and Staphylococcal Infections, Chicago, IL, USA , 26-AUG-14 - 29-AUG-14. [Details]
(2012) International Symposium on Staphylococci and Staphylococcal Infections,
Elaine M. Waters, Clarissa Pozzi, Carolyn R. Schaeffer, Justine K. Rudkin, Amanda J. Lohan, Pin Tong, Brendan J. Loftus, Gerald B. Pier, Paul D. Fey, Ruth C. Massey and James P. O'Gara (2012) Methicillin Resistance Alters the Biofilm Phenotype and Attenuates Virulence in Staphylococcus aureus Device-Associated Infections. [International Refereed Conference], International Symposium on Staphylococci and Staphylococcal Infections, Lyon, France , 26-AUG-12 - 30-AUG-12. [Details]
(2012) International Symposium on Staphylococci and Staphylococcal Infections,
Hannah E. McCarthy, Elaine M. Waters, Sarah E. Rowe, Joan A. Geoghegan, Simon J. Foster, Timothy J. Foster, Eoghan O'Neill and James P. O'Gara (2012) Evidence that the major autolysin has potential as a novel therapeutic target against Staphylococcus aureus biofilm formation. [International Refereed Conference], International Symposium on Staphylococci and Staphylococcal Infections, Lyon, France , 26-AUG-12 - 30-AUG-12. [Details]
(2012) International Symposium on Staphylococci and Staphylococcal Infections,
S. Hogan, J.P. O'Gara and M. Folan (2012) Novel Antimicrobial Solution Based on Free Fatty Acids and Membrane Lipids has Ability to Disrupt Established Biofilm in Medical Device Model. [International Refereed Conference], International Symposium on Staphylococci and Staphylococcal Infections, Lyon, France , 26-AUG-12 - 30-AUG-12. [Details]
(2011) Gordon Research Conference on Staphylococci and Staphylococcal Infections,
Waters EM, Pozzi C, Schaeffer C, Rudkin J, Pier GB, Massey RC, Fey PD, O'Gara JP. (2011) Methicillin resistance in Staphylococcus aureus results in an altered biofilm phenotype and reduced virulence. [International Refereed Conference], Gordon Research Conference on Staphylococci and Staphylococcal Infections, Tuscany, Italy , 24-JUL-11 - 29-JUL-11. [Details]
(2008) 18th European Congress of Clinical Microbiology and Infectious Diseases,
E. O'Neill, C. Pozzi, T. Foster, H. Humphreys, J. O'Gara (2008) A novel Staphylococcus aureus biofilm phenotype mediated by the fibronectin-binding proteins, FnBPA and FnBPB. [Published Abstract], 18th European Congress of Clinical Microbiology and Infectious Diseases, Barcelona, Spain , 19-APR-08 - 23-APR-08. [Details]
(2006) 16th European Congress of Clinical Microbiology and Infectious Diseases,
N. Stevens, H. Humphreys, E. O'Neill, J.P. O'Gara, C. Greene, T. Dillane, T. Sattar (2006) Contribution of biofilm phenotype to the pathogenesis of Staphylococcus epidermidis neurosurgical device-related meningitis. [Published Abstract], 16th European Congress of Clinical Microbiology and Infectious Diseases, Nice, France , 01-APR-06 - 04-APR-06. [Details]
(2006) 16th European Congress of Clinical Microbiology and Infectious Diseases,
E. O'Neill, H. Humphreys, J.P. O'Gara (2006) Genetic analysis of the biofilm phenotype in methicillin-resistant Staphylococcus aureus. [Published Abstract], 16th European Congress of Clinical Microbiology and Infectious Diseases, Nice, France , 01-APR-06 - 04-APR-06. [Details]
(2005) 15th European Congress of Clinical Microbiology and Infectious Diseases,
E. O'Neill, T. Sexton, T. Dillane, P. Clarke, J. O'Gara, E. Smyth, H. Humphreys (2005) Comparison of patient and environmental strains of MRSA using PFGE. [Published Abstract], 15th European Congress of Clinical Microbiology and Infectious Diseases, Copenhagen, Denmark , 02-MAY-05 - 05-MAY-05. [Details]
(2004) American Society for Microbiology Annual General Meeting,
Kennedy CM, Humphreys H, O'Gara JP (2004) Parameters controlling the regulation of biofilm under laboratory conditions. [Published Abstract], American Society for Microbiology Annual General Meeting, New Orleans, LA , 23-MAY-04 - 27-MAY-04. [Details]
(2004) American Society for Microbiology Annual General Meeting,
Conlon KM, Humphreys H, O'Gara JP. (2004) Environmental regulation of the biofilm regulator icaR in Staphylococcus epidermidis. [Published Abstract], American Society for Microbiology Annual General Meeting, New Orleans, LA , 23-MAY-04 - 27-MAY-04. [Details]
(2003) American Society for Microbiology Annual General Meeting,
Conlon KM, Humphreys H, O'Gara JP. (2003) icaR encodes a transcriptional repressor of the icaADBC operon. [Published Abstract], American Society for Microbiology Annual General Meeting, Washington DC , 18-MAY-03 - 22-MAY-03. [Details]
(2003) 13th European Congress of Clinical Microbiology and Infectious Diseases,
F. M. Fitzpatrick, H. Humphreys, E. C. Smyth, J. P. O'Gara (2003) Biofilm forming capacity of neurosurgical Staphylococcus epidermidis isolates. [Published Abstract], 13th European Congress of Clinical Microbiology and Infectious Diseases, Glasgow, UK , 10-MAY-03 - 13-MAY-03. [Details]
(2002) American Society for Microbiology Annual General Meeting,
Conlon KM, Humphreys H, O'Gara JP. (2002) Regulation of the Staphylococcus epidermidis biofilm phenotype. [Published Abstract], American Society for Microbiology Annual General Meeting, Salt Lake City, UT , 19-MAY-02 - 23-MAY-02. [Details]
(2001) American Society for Microbiology Annual General Meeting,
Conlon, KM, Humphreys H and O'Gara JP (2001) Phenotypic variation of biofilm formation in Staphylococcus epidermidis. [Published Abstract], American Society for Microbiology Annual General Meeting, Orlando, FL , 20-MAY-01 - 24-MAY-01. [Details]

Honours and Awards

  Year Title Awarding Body
2022 Member of the Royal Irish Academy (MRIA) Royal Irish Academy
2019 Fellow, International Society for Antimicrobial Chemotherapy (FISAC) International Society for Antimicrobial Chemotherapy
2018 DSc National University of Ireland

Patents

  Patent Number Title Granted
European Patent Application No. 24210388.5 Antibiotic compositions

Committees

  Committee Function From / To
University of Galway Governing Authority Elected Member (Professorial Panel) 01-FEB-21 /
Strategic and Standing Committee Member 01-FEB-21 /
Journal of Medical Microbiology Editorial Board Editor (Antimicrobial Resistance) 01-SEP-24 / 31-AUG-27
mSphere Board of Editors Editor 01-AUG-24 / 31-JUL-27

Employment

  Employer Position From / To
University College Dublin Senior Lecturer 01-APR-05 / 31-JUL-12
Royal College of Surgeons in Ireland Senior Lecturer 01-SEP-99 / 31-MAR-05

Current Postgraduate Students (Taught)

  Name Degree Primary Supervisor
Anita Amorim PhD

Recent Postgraduate Students

  Graduation Name Degree Primary Supervisor
2021 Claire Fingleton PhD Y
2019 Christopher Campbell PhD Y
2017 Laura A. Gallagher PhD Y
2017 Nikki S. Black PhD Y
2016 Colm Lowry Masters Y
2015 Hannah McCathy PhD Y
2013 Siobhan Hogan Masters Y
2012 Elaine Waters PhD Y
2011 Brian Conlon PhD Y
2010 Sarah Rowe PhD Y
2010 Patrick Houston PhD Y
2009 Clarissa Pozzi PhD Y
2009 Linda Holland PhD Y
2009 John Cotter PhD
2009 Kay Oduwole Masters Y
2008 Niall Stevens PhD
2008 Eoghan O'Neill PhD Y
2007 Maria Boyle PhD
2007 Sinead O'Donnell PhD Y
2007 Aaron Glynn Masters Y
2005 Ciara Kennedy PhD Y
2005 Fidelma Fitzpatrick Doctor of Medicine Y
2004 Salah Elbaruni Masters Y
2004 Kevin Conlon PhD Y

Current Postgraduate Students (Research)

  Student Degree Type Type
Orla Burke Doctorate - Structured PhD (Science) Supervisor
Chloe Hobbs Doctorate - Structured PhD (Science) Supervisor
Aaron Nolan Doctorate - Structured PhD (Science) Supervisor
John Ivory Doctorate - Structured Ph.D (Health Studies) Co-supervisor (1)
Jessica Kelly Doctorate - Structured PhD (Science) Co-supervisor (1)

Modules Taught

  Term/Year Module Title Module Code Subject / Desc
2024/2025 Bacterial Pathogenesis MI437 Microbiology
2024/2025 Host Microbe Interactions MI4101 Advanced microbial virulence and antibiotic resistance
2024/2025 Microbial Infectious Diseases MI325 Microbial virulence, antibiotic resistance
2024/2025 Microbial Molecular and Metabolic Systems MI326 Microbial metabolism
2024/2025 Molecular and Cellular Biology BO201 Biochemistry, Microbiology, Plant Science
2023/2024 Biology BO101 Biology, Microbiology
2019/2020 The Meaning of Life: Bioinformatics MI439 Microbiology

Internal Collaborators

  Name Description of Collaboration
Dr Merve Zeden

External Collaborators

  Name Organisation / Institute Country Description of Collaboration
Paul Fey University of Nebraska Medical Centre U.S.A.
Vinai Thomas University of Nebraska Medical Centre U.S.A.
Barbara Kahl University of Muenster GERMANY
Aras Kadioglu University of Liverpool UNITED KINGDOM
Eoghan O'Neill Royal College of Surgeons in Ireland IRELAND
Josh Adkins Pacific Northwest National Laboratory U.S.A.
Felipe Cava University of Umea SWEDEN