Dr. Syeda Naqvi

B.Sc., M.Sc., PhD

Contact Details

Research Fellow
E: syeda.masoomanaqvi@universityofgalway.ie
 
researcher
 

Biography

Dr Syeda Masooma Naqvi joined the Mechanobiology and Medical Device Research Group in October 2017 after receiving her PhD from the internationally recognized Trinity College Dublin (TCD), where she investigated the specific environmental conditions that can aid in stem cell-based regeneration of the intervertebral disc. Prior to this Masooma received her MSc (Clinical Research) from University of Galway where she also received her BSc in Biomedical Science. After she was awarded her PhD in Biomedical Engineering, she took up a Postdoctoral Researcher post in University of Galway where she diversified her research into the area of bone disease. She established a simplified 3D in vitro osteocyte model that mimics the mechanical environment in vivo in an attempt to further understand the mechanisms by which osteocytes sense and respond to mechanical signals in postmenopausal Osteoporosis. This work received much attention at the Orthopaedic Research Society Annual Meeting 2020, where she presented it at a Spotlight Session. More recently, she has developed advanced in vitro models that are mimetic of the complex multicellular (osteocytes, osteoblasts, vascularisation, macrophages, progenitors) and mechanical (hydrostatic pressure and compression/perfusion) bone environment during postmenopausal Osteoporosis. Nationally, this work was recognized as the best overall paper presented at the 27th Bioengineering in Ireland Annual Meeting 2022 for which she was awarded the Royal Academy of Medicine in Ireland Bronze Medal. In other works, she has investigated the combined influence of matrix stiffness (mimetic of bone marrow) and breast cancer-bone cell signaling on spheroid formation and shown that spheroid size is significantly reduced under high stiffness versus low stiffness. Breast cancer cells comprise a subpopulation of cells with key stem-cell properties that initiates and drives carcinogenesis and differentiation which contributes to tumor cellular heterogeneity and are likely responding to the change in stiffness as is evidenced by differential spheroid size. She has secured a number of grants, such as the  Athena Swan Research Capacity Building grant, to investigate this hypothesis.
Link to publications
https://scholar.google.com/citations?user=h6Yum-IAAAAJ&hl=en


Research Projects

  Project Start Date End Date
Investigating the Role of Biophysical and Biomechanical Factors in Breast Cancer Stemness: Implications for Novel Mechano-therapeutics and Ex Vivo Models. 01-SEP-23 31-AUG-25
Mechanobiological role in cancer stemness, drug resistance, and metastatic dissemination 17-NOV-22 16-DEC-23
Breast cancer stem cell response to changes in stiffness and mechanical stimulation. 01-OCT-22 30-SEP-23

Contract Researchers

  Researcher Name Project Role Funding Body
MOFEHINTIOLUWA AKINYEMI Mechanobiological role in cancer stemness, drug resistance, and metastatic dissemination Research Assistant
Sailakshmi Senthilkumar Investigating the Role of Biophysical and Biomechanical Factors in Breast Cancer Stemness: Implications for Novel Mechano-therapeutics and Ex Vivo Models. Research Assistant

Peer Reviewed Journals

  Year Publication
(2024) 'A mechanobiological model of bone metastasis reveals that mechanical stimulation inhibits the pro-osteolytic effects of breast cancer cells'
Vatsal Kumar, Syeda M Naqvi, Anneke Verbruggen, Eoin McEvoy, Laoise M McNamara (2024) 'A mechanobiological model of bone metastasis reveals that mechanical stimulation inhibits the pro-osteolytic effects of breast cancer cells'. Cell Reports, 43 (5) [Details]
(2020) 'A Novel 3D Osteoblast and Osteocyte Model Revealing Changes in Mineralization and Pro-osteoclastogenic Paracrine Signaling During Estrogen Deficiency'
Naqvi, SM;Perez, JAP;Kumar, V;Verbruggen, ASK;McNamara, LM (2020) 'A Novel 3D Osteoblast and Osteocyte Model Revealing Changes in Mineralization and Pro-osteoclastogenic Paracrine Signaling During Estrogen Deficiency'. Frontiers in Bioengineering and Biotechnology, 8 [DOI] [Details]
(2020) 'Stem Cell Mechanobiology and the Role of Biomaterials in Governing Mechanotransduction and Matrix Production for Tissue Regeneration'
Naqvi SM;McNamara LM; (2020) 'Stem Cell Mechanobiology and the Role of Biomaterials in Governing Mechanotransduction and Matrix Production for Tissue Regeneration'. Frontiers in Bioengineering and Biotechnology, 8 [DOI] [Details]
(2019) 'In vitro co-culture and ex vivo organ culture assessment of primed and cryopreserved stromal cell microcapsules for intervertebral disc regeneration'
Naqvi SM;Gansau J;Gibbons D;Buckley CT; (2019) 'In vitro co-culture and ex vivo organ culture assessment of primed and cryopreserved stromal cell microcapsules for intervertebral disc regeneration'. European Cells & Materials, 37 [DOI] [Details]
(2018) 'Priming and cryopreservation of microencapsulated marrow stromal cells as a strategy for intervertebral disc regeneration'
Naqvi SM;Gansau J;Buckley CT; (2018) 'Priming and cryopreservation of microencapsulated marrow stromal cells as a strategy for intervertebral disc regeneration'. Biomedical Materials, 13 (3) [DOI] [Details]
(2016) 'Living Cell Factories - Electrosprayed Microcapsules and Microcarriers for Minimally Invasive Delivery'
Naqvi, SM;Vedicherla, S;Gansau, J;McIntyre, T;Doherty, M;Buckley, CT (2016) 'Living Cell Factories - Electrosprayed Microcapsules and Microcarriers for Minimally Invasive Delivery'. Advanced Materials (Deerfield Beach, Fla.), 28 :5662-5671 [DOI] [Details]
(2016) 'Bone Marrow Stem Cells in Response to Intervertebral Disc-Like Matrix Acidity and Oxygen Concentration'
Naqvi, SM;Buckley, CT (2016) 'Bone Marrow Stem Cells in Response to Intervertebral Disc-Like Matrix Acidity and Oxygen Concentration'. Spine, 41 :743-750 [DOI] [Details]
(2015) 'Differential Response of Encapsulated Nucleus Pulposus and Bone Marrow Stem Cells in Isolation and Coculture in Alginate and Chitosan Hydrogels'
Naqvi, SM;Buckley, CT (2015) 'Differential Response of Encapsulated Nucleus Pulposus and Bone Marrow Stem Cells in Isolation and Coculture in Alginate and Chitosan Hydrogels'. Tissue Engineering Part A, 21 :288-299 [DOI] [Details]
(2015) 'Enhancing cell migration in shape-memory alginate-collagen composite scaffolds: In vitro and ex vivo assessment for intervertebral disc repair'
Guillaume, O;Naqvi, SM;Lennon, K;Buckley, CT (2015) 'Enhancing cell migration in shape-memory alginate-collagen composite scaffolds: In vitro and ex vivo assessment for intervertebral disc repair'. Journal Of Biomaterials Applications, 29 :1230-1246 [DOI] [Details]
(2015) 'Extracellular matrix production by nucleus pulposus and bone marrow stem cells in response to altered oxygen and glucose microenvironments'
Naqvi, SM;Buckley, CT (2015) 'Extracellular matrix production by nucleus pulposus and bone marrow stem cells in response to altered oxygen and glucose microenvironments'. Journal Of Anatomy, 227 :757-766 [DOI] [Details]

Conference Publications

  Year Publication
(2022) TISSUE ENGINEERING PART A
Syeda Masooma Naqvi, Vatsal Kumar, Laoise McNamara (2022) MECHANOBIOLOGICALLY MIMETIC MODEL SYSTEMS OF HEALTHY AND METASTATIC BONE TISSUE ENGINEERING PART A , pp.S407-S408 [Details]
(2018) Orthopaedic Proceedings
SM Naqvi, JAP Perez, LM McNamara (2018) MECHANOBIOLOGICAL RESPONSES OF OSTEOBLASTS IN 3D HYDROGEL UNDER OESTROGEN WITHDRAWAL AND MECHANICAL STIMULATION Orthopaedic Proceedings [Details]
(2015) TISSUE ENGINEERING PART A
SM Naqvi, J Gansau, CT Buckley (2015) Cryopreservation of Primed Microencapsulated Bone Marrow Derived Stem Cells using Electrohydrodynamic Spraying for on Demand Minimally Invasive Tissue Regeneration of the Intervertebral Disc TISSUE ENGINEERING PART A [Details]
(2015) TISSUE ENGINEERING PART A
SM Naqvi, CT Buckley (2015) Bone Marrow-Derived Stem Cells in Response to Intervertebral Disc-Like Matrix Acidity-Implications for Cell-Based Regenerative Therapy TISSUE ENGINEERING PART A [Details]
(2014) JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
SM Naqvi, C Buckley (2014) Response of bone marrow-derived stem cells cultured in intervertebral disc-like microenvironmental conditions JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE [Details]
(2014) JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
L Kelly, O Guillaume, SM Naqvi, A Robinson, C Buckley (2014) Cell microencapsulation using electrohydrodynamic spraying for minimally invasive tissue repair JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE [Details]

Honours and Awards

  Year Title Awarding Body
2023 Best Mechanobiology Research Oral Presentation Mature Research Category Bioengineering in Ireland
2022 Royal Academy of Medicine in Ireland (RAMI) Bronze Medal Royal Academy of Medicine in Ireland (RAMI)
2019 Best Group Presentation Biomechanics Winter Collisions Symposium
2014 'Thesis in 3' - Best Presentation Trinity Centre for Bioengineering Winter Symposium
2013 Student Travel Bursary Award Bioengineering in Ireland

Professional Associations

  Association Function From / To
European Association for Cancer Research Member 01-SEP-23 /
New York Academy of Sciences (NYAS) Member 01-APR-21 / 31-MAR-22
Orthopaedic Research Society (ORS) Member 01-SEP-19 / 31-AUG-23
Tissue Engineering and Regenerative Medicine International Society(TERMIS) Member 01-SEP-12 / 31-DEC-21
European Orthopaedic Research Society (EORS) Member 01-SEP-18 / 31-AUG-19

Employment

  Employer Position From / To
National University of Ireland Galway Postdoctoral Researcher 01-OCT-17 /
Trinity College Dublin Project Manager 03-OCT-16 / 31-JAN-17
University Hospital Galway MSc Student Research Fellow 01-NOV-09 / 29-FEB-12

Education

  Year Institution Qualification Subject
2016 Trinity College Dublin PhD Biomedcial Engineering
2011 National University of Ireland Galway MASTERS OF SCIENCE Clinical Research
2009 National University of Ireland Galway BACHELOR OF SCIENCE Biomedical Sciences

Languages

  Language
Persian
Gaeilge
French
Hindi
English

Recent Postgraduate Students

  Graduation Name Degree Primary Supervisor
2023 Sailakshmi Senthilkumar M.Sc in Regenerative Medicine Y
2020 Ciara Joyce MSc in Biomedical Science
2019 Jyotsna Dhanyasi (Claudia) MSc in Biomedical Science
2018 Vatsal Kumar MASTER OF ENGINEERING

Modules Taught

  Term/Year Module Title Module Code Subject / Desc
2022/2023 Biomedical Engineering Physiology BME3133 Cardiovascular and Respiratory Physiology
2022/2023 Principles of Biomaterials BME328 Foreign Body Response, Biomaterials Surface Properties, Soft and Hard Tissue Implants, Blood Contacting Implants, Biomaterial Infections, Sterilisation Methods, Additive and Subtracting Manufacturing, Bioprinting, Composite Biomaterial, Decellularized Matrices
2021/2022 Introduction to Biomaterials BME200 Cells and Tissue, The Extracellular Matrix, Biological Characterisation of Biomaterials, Biomaterial Biodegradation, Introduction to Scaffolds and Tissue Engineering
2019/2020 Mechanobiology BME510 Stem Cell Mechanobiology; Cancer Mechanobiology

Internal Collaborators

  Name Description of Collaboration
Dr. Roisin Dwyer
Professor Aoife Lowery