Engineering

Dr Eoin McEvoy

BE,PhD

Contact Details

Senior Lecturer
Engineering Building - Alice Perry
Room No. 2004 Second Floor
University of Galway
Galway
E: eoin.mcevoy@universityofgalway.ie

Biography

Research Career:

2024 - present: Associate Professor (Senior Lecturer) in Biomedical Engineering, College of Science and Engineering, University of Galway

2020 - 2024: Assistant Professor (Lecturer) in Biomedical Engineering, College of Science and Engineering, University of Galway

2019 - 2020: Postdoctoral Researcher: University of Pennsylvania, Philadelphia, USA

2018 - 2019: Postdoctoral Researcher: National University of Ireland Galway, Ireland

Dr Eóin McEvoy is an Associate Professor (Lecturer) in Biomedical Engineering at the University of Galway. His research focuses primarily on computational cell/tissue mechanics and disease mechanobiology.

Research Interests: Computational cancer mechanobiology; Cellular contractility and adhesion; Mechanics of soft tissue; Biological thermodynamics; Growth and remodelling; Theoretical model development; Medical device design; Cardiovascular tissue modeling; Computational and experimental biomechanics; Finite element methods; Continuum mechanics.

Teaching: Biomedical Engineering Design II (BME3135); Finite Element Methods in Engineering II (BME5104); Engineering Analysis for Regulatory Approval (BME4103); Fundamentals of Engineering (EI140);

Research Interests

Computational cancer mechanobiology; Cellular contractility and adhesion; Mechanics of soft tissue; Biological thermodynamics; Growth and remodelling; Theoretical model development; Medical device design; Cardiovascular tissue modeling; Computational and experimental biomechanics; Finite element methods; Continuum mechanics.

Peer Reviewed Journals

	Year	Publication
	(2022)	'Feedback between mechanosensitive signalling and active forces governs endothelial junction integrity' McEvoy, E., Sneh, T., Moeendarbary, E., Javanmardi, Y., Efimova, N., Yang, C., Marino, G., Chen, X., Escribano, J., Spill, F., Garcia-Aznar, J.M., Weeraratna, A., Svitkina, T., Kamm, R., Shenoy, V. (2022) 'Feedback between mechanosensitive signalling and active forces governs endothelial junction integrity'. Nature Communications, [DOI] [Details]
	(2022)	'Thermodynamically-motivated chemo-mechanical models and multicellular simulation to provide new insight into active cell and tumour remodelling' Senthilkumar, I., Howley, E., McEvoy, E. (2022) 'Thermodynamically-motivated chemo-mechanical models and multicellular simulation to provide new insight into active cell and tumour remodelling'. Experimental Cell Research, [DOI] [Details]
	(2021)	'Recursive feedback between matrix dissipation and chemo-mechanical signaling drives oscillatory growth of cancer cell invadopodia' Gong, Z., Wisdom, K., McEvoy, E., Adebowale, K., Chaudhuri, O., Shenoy, V. (2021) 'Recursive feedback between matrix dissipation and chemo-mechanical signaling drives oscillatory growth of cancer cell invadopodia'. Cell Reports, [DOI] [Details]
	(2021)	'Image-derived modeling of nucleus strain amplification associated with chromatin heterogeneity' Reynolds, N., McEvoy, E., Ghosh, S., Pérez, J., Neu, C., McGarry, P. (2021) 'Image-derived modeling of nucleus strain amplification associated with chromatin heterogeneity'. Biophysical journal, [DOI] [Details]
	(2021)	'A thermodynamic transient cross-bridge model for prediction of contractility and remodelling of the ventricle' McEvoy, E,Wijns, W,McGarry, P (2021) 'A thermodynamic transient cross-bridge model for prediction of contractility and remodelling of the ventricle'. Journal Of The Mechanical Behavior Of Biomedical Materials, 113 [DOI] [Details]
	(2020)	'Gap Junctions Amplify Spatial Variations in Cell Volume in Proliferating Solid Tumors' McEvoy, Eoin and Han, Yulong and Guo, Ming and Shenoy, Vivek (2020) 'Gap Junctions Amplify Spatial Variations in Cell Volume in Proliferating Solid Tumors'. Nature Communications, 11 [DOI] [Details]
	(2020)	'Yielding and bifurcated aging in nanofibrillar networks' Poling-Skutvik, R., McEvoy, E., Shenoy, V., Osuji, C. (2020) 'Yielding and bifurcated aging in nanofibrillar networks'. Physical Review Materials, [DOI] [Details]
	(2020)	'Influence of multi-axial dynamic constraint on cell alignment and contractility in engineered tissues' Reynolds, NH,McEvoy, E,Perez, JAP,Coleman, RJ,McGarry, JP (2020) 'Influence of multi-axial dynamic constraint on cell alignment and contractility in engineered tissues'. Journal Of The Mechanical Behavior Of Biomedical Materials, 112 [DOI] [Details]
	(2019)	'Transient active force generation and stress fibre remodelling in cells under cyclic loading' McEvoy, E;Deshpande, VS;McGarry, P (2019) 'Transient active force generation and stress fibre remodelling in cells under cyclic loading'. Biomechanics And Modeling In Mechanobiology, 18 :921-937 [DOI] [Details]
	(2018)	'Thermodynamic Modeling of the Statistics of Cell Spreading on Ligand-Coated Elastic Substrates' McEvoy, E,Shishvan, SS,Deshpande, VS,McGarry, JP (2018) 'Thermodynamic Modeling of the Statistics of Cell Spreading on Ligand-Coated Elastic Substrates'. Biophysical journal, 115 :2451-2460 [DOI] [Details]
	(2018)	'Compressibility and Anisotropy of the Ventricular Myocardium: Experimental Analysis and Microstructural Modeling' McEvoy E;Holzapfel GA;McGarry P; (2018) 'Compressibility and Anisotropy of the Ventricular Myocardium: Experimental Analysis and Microstructural Modeling'. Journal Of Biomechanical Engineering-Transactions Of The Asme, 140 (8) [DOI] [Details]
	(2017)	'Free energy analysis of cell spreading' McEvoy, E,Deshpande, VS,McGarry, P (2017) 'Free energy analysis of cell spreading'. Journal Of The Mechanical Behavior Of Biomedical Materials, 74 :283-295 [DOI] [Details]

Conference Publications

	Year	Publication
	(2024)	*Recent Advances in Mechanics and Mathematics of Materials* McEvoy, E. (2024) Mechanobiology of stress-dependent cell and tumour growth Recent Advances in Mechanics and Mathematics of Materials [Details]
	(2023)	*28th Congress of the European Society of Biomechanics* McEvoy, E. (2023) Chemo-mechanical models of active cell forces in growth and remodelling 28th Congress of the European Society of Biomechanics [Details]
	(2023)	*Euromech Colloquium on Cellular Mechanobiology and Morphogenesis* McEvoy, E. (2023) Mechanobiology of stress-dependent cell and tumour growth Euromech Colloquium on Cellular Mechanobiology and Morphogenesis [Details]
	(2023)	*International Conference on Computational Bioengineering* McEvoy, E. (2023) Coupled agent-based and finite-element models for analysis of force-sensitive cell and tumour growth International Conference on Computational Bioengineering [Details]
	(2023)	*28th Congress of the European Society of Biomechanics* Senthilkumar, I., Howley, E., McEvoy, E. (2023) An Integrated Finite Element and Agent-Based Model to Analyse Mechanosensitive Tumour Growth 28th Congress of the European Society of Biomechanics [Details]
	(2022)	*11th European Solid Mechanics Conference (ESMC)* Huxford, B. and McEvoy, E. (2022) A theoretical model for the stress-dependence of cell and tissue growth 11th European Solid Mechanics Conference (ESMC) [Details]
	(2022)	*11th European Solid Mechanics Conference (ESMC)* Senthilkumar, I., Howley, E., McEvoy, E. (2022) Agent-Based Modelling of Mechanosensitive Tumour Growth 11th European Solid Mechanics Conference (ESMC) [Details]
	(2022)	*11th European Solid Mechanics Conference (ESMC)* Vatsal Kumar, Eoin McEvoy, Laoise McNamara (2022) 3D tumor-bone cell in-vitro and computational model reveals synergistic effect of bone cells and matrix stiffness on tumor spheroid growth 11th European Solid Mechanics Conference (ESMC) [Details]
	(2022)	*Engineers' Ireland Research Medal Talk at Bioengineering in Ireland* Vatsal Kumar, Syeda Masooma Naqvi, Eoin McEvoy, Laoise McNamara (2022) MECHANOBIOLOGICALLY MIMETIC MODEL SYSTEMS FOR STUDYING BREAST CANCER METASTASIS TO BONE Engineers' Ireland Research Medal Talk at Bioengineering in Ireland [Details]
	(2022)	*Computational Oncology and Personalised Medicine* Senthilkumar, I., Howley, E., McEvoy, E. (2022) Agent-Based Modelling of Stress-Dependent Tumour Growth Computational Oncology and Personalised Medicine [Details]
	(2022)	*27th Congress of the European Society of Biomechanics* Huxford, B., Kumar, V., McNamara, L., McEvoy, E. (2022) Theoretical and Experimental Modelling of Cell and Tumour Growth 27th Congress of the European Society of Biomechanics [Details]
	(2021)	*European Association of Cancer Research, Goodby Flat Biology* Vatsal Kumar, Syeda M. Naqvi, Eoin McEvoy, Laoise M. McNamara (2021) A 3D tumor¿bone cell model reveals synergistic influence of bone cells and matrix stiffness for tumour spheroid growth European Association of Cancer Research, Goodby Flat Biology [Details]
	(2021)	*16th International Conference on Computational Plasticity (COMPLAS 2021, Barcelona)* McEvoy, E., Han, Y., Guo, M., Shenoy, V. (2021) (2021) A mechano-osmotic model to uncover the role of gap junctions in cell swelling within proliferative tumour organoids 16th International Conference on Computational Plasticity (COMPLAS 2021, Barcelona) [Details]
	(2021)	*Summer Biomechanics, Bioengineering, and Biotransport Conference (SB3C)* McEvoy, E., Sneh, T., Moeendarbary, E., Chen, X., Svitkina, T., Kamm, R., Shenoy, V. (2021) Modeling the Three-Way Chemo-Mechanical Feedback between Cellular Contractility, Actin Polymerization, and Adhesion Turnover in the Remodeling of Endothelial Junctions Summer Biomechanics, Bioengineering, and Biotransport Conference (SB3C) [Details]
	(2021)	*American Physics Society (APS) March Meeting* McEvoy, E., Han, Y., Guo, M., Shenoy, V. (2021) Spatial variation in cell volume within proliferating tumorigenic cell clusters is amplified by gap-junction-mediated ion flow American Physics Society (APS) March Meeting [Details]
	(2020)	*Biomedical Engineering Society Annual Meeting (BMES)* McEvoy, E., Han, Y., Guo, M., Shenoy, V. (2020) Gap Junction Mediated Ion Transport Drives Spatial Differences in Cell Volume in Growing Clusters Biomedical Engineering Society Annual Meeting (BMES) [Details]
	(2020)	*Summer Biomechanics, Bioengineering, and Biotransport Conference (SB3C)* McEvoy, E., Chen, X., Ranamukhaarachchi, S., Fraley, S., Shenoy, V. (2020) An active free-energy model to predict cancer cell streaming and invasion Summer Biomechanics, Bioengineering, and Biotransport Conference (SB3C) [Details]
	(2019)	*Summer Biomechanics, Bioengineering and Biotransport Conference (SB3C)* McEvoy, E., McGarry, J.P. (2019) A thermodynamically motivated cross-bridge cycling framework to predict myofibril remodeling under conditions associated with LV hypertrophy Summer Biomechanics, Bioengineering and Biotransport Conference (SB3C) [Details]
	(2019)	*Summer Biomechanics, Bioengineering and Biotransport Conference (SB3C)* Coleman, R., McEvoy, E., McGarry, J.P. (2019) Contractility Modelling Towards Predicting Eccentric Hypertrophy and Fibre Alignment Summer Biomechanics, Bioengineering and Biotransport Conference (SB3C) [Details]
	(2018)	*10th European Solid Mechanics Conference (ESMC)* McEvoy, E., Deshpande, V.S., McGarry, J.P., (2018) Thermodynamics of Cell Spreading on Ligand Coated Elastic Substrates 10th European Solid Mechanics Conference (ESMC) [Details]
	(2018)	*10th European Solid Mechanics Conference (ESMC)* McEvoy, E., Holzapfel, G.A., McGarry, J.P., (2018) A micro-structural model of the ventricular myocardium 10th European Solid Mechanics Conference (ESMC) [Details]
	(2018)	*8th World Congress of Biomechanics (WCB)* McEvoy, E., Shishvan, S.S., Deshpande, V.S., McGarry, J.P., (2018) A thermodynamic framework for cell spreading and dynamic contractility 8th World Congress of Biomechanics (WCB) [Details]
	(2018)	*8th World Congress of Biomechanics (WCB)* O'Connor, C., McEvoy, E., McGarry, J.P., (2018) A Numerical Method for the Implementation of Discrete Fibre Dispersion 8th World Congress of Biomechanics (WCB) [Details]
	(2017)	*Summer Biomechanics, Bioengineering, and Biotransport Conference (SB3C)* McEvoy, E.; Shishvan, S.S.; McGarry, J.P.; Deshpande, V.S. (2017) A Thermodynamic Statistical Mechanics Model to Investigate the Influence of Ligand Density and Substrate Stiffness on Cell Spreading Summer Biomechanics, Bioengineering, and Biotransport Conference (SB3C) Arizona, USA, [Details]
	(2017)	*Summer Biomechanics, Bioengineering and Biotransport Conference (SB3C)* O’Connor, C.A.; Nolan, D.R.; McEvoy, E.; McGarry, J.P. (2017) Three Part Hyperelastic Law for Anisotropic Aortic Tissue: Model Development and Experimental Validation Summer Biomechanics, Bioengineering and Biotransport Conference (SB3C) Arizona, USA, [Details]
	(2017)	*Summer Biomechanics,Bioengineering and Biotransport Conference (SB3C)* Reynolds, N.; McEvoy, E.; Deshpande, V.S.; McGarry, J.P. (2017) A continuum finite element model predicting cell motility Summer Biomechanics,Bioengineering and Biotransport Conference (SB3C) Arizona, USA, [Details]
	(2017)	*Summer Biomechanics, Bioengineering and Biotransport Conference (SB3C)* Reynolds, N., McEvoy, E., Despande, V.S., McGarry, J.P., (2017) Cell Force Generation in Biaxially and Uniaxially Loaded Tissues Summer Biomechanics, Bioengineering and Biotransport Conference (SB3C) [Details]
	(2017)	*International Conference of Biomedical Technology (ECCOMAS)* McEvoy, E., Shishvan, S.S., Deshpande, V.S., McGarry, J.P., (2017) Modelling cell-substrate interaction to investigate the influence of collagen density and stiffness on cell spreading International Conference of Biomedical Technology (ECCOMAS) [Details]
	(2016)	*Summer Biomechanics, Bioengineering, and Biotransport Conference (SB3C)* McEvoy, E.; Ristori, T.; Loerakker, S.; Deshpande, V.S.; McGarry, J.P. (2016) Analysis of Cell Spreading on Micropatterned Substrates Using a Thermodynamically Consistent Non-Local Active Model Summer Biomechanics, Bioengineering, and Biotransport Conference (SB3C) National Harbor, MA, USA, [Details]
	(2016)	*19th Sir Bernard Crossland Symposium* McEvoy, E.; McGarry, J.P. (2016) Remodelling of Cardiac Cells and Tissue: A Multi-Scale Framework 19th Sir Bernard Crossland Symposium Belfast, Northern Ireland, [Details]
	(2015)	*Irish Mechanics Society (IMS) and the Irish Society for Scientific Engineering & Computation (ISSEC)* McEvoy, E.; Deshpande, V.S.; McGarry, J.P. (2015) Anisotropy, Compressibility, and Contractility of the Myocardial Tissue Irish Mechanics Society (IMS) and the Irish Society for Scientific Engineering & Computation (ISSEC) Dublin, Ireland, [Details]

Book Chapters

	Year	Publication
	(2024)	'Chapter 6 - Mechanobiology regulation' McEvoy, E., McNamara, L.M. (2024) 'Chapter 6 - Mechanobiology regulation' In: Multiscale Cell-Biomaterials Interplay in Musculoskeletal Tissue Engineering and Regenerative Medicine. Cambridge, Massachusetts: Academic Press. [DOI] [Details]

Other Journals

	Year	Publication
	(2022)	'A novel mechanobiological model of bone metastasis reveals that mechanical stimulation inhibits the pro-osteoclastogenic effects of breast cancer cells' Vatsal Kumar, Syeda Masooma Naqvi, Anneke VERBRUGGEN, Eoin McEvoy, Laoise McNamara (2022) 'A novel mechanobiological model of bone metastasis reveals that mechanical stimulation inhibits the pro-osteoclastogenic effects of breast cancer cells' bioRxiv, . [DOI] [Details]
	(2020)	'An active chemo-mechanical model predicts adhesion and microenvironmental regulation of 3D cell shapes' Chen, X., te Boekhorst, V., McEvoy, E., Friedl, P, Shenoy, V. (2020) 'An active chemo-mechanical model predicts adhesion and microenvironmental regulation of 3D cell shapes' biorxiv, . [DOI] [Details]
	(2020)	'Investigation of cell nucleus heterogeneity' Noel Reynolds, Eoin McEvoy, Soham Ghosh, Juan Alberto Panadero Pérez, Corey P. Neu, Patrick McGarry (2020) 'Investigation of cell nucleus heterogeneity' BioRxiv - Biology Preprint Server, . [DOI] [Details]

Professional Associations

Association	Function	From / To
European Society of Biomechanics	Member	/
European Solid Mechanics Society	Member	/
Irish Association for Cancer Research	Member	/
European Association for Cancer Research	Member	/

Teaching Interests

Biomedical Engineering Design II (BME3135); Finite Element Methods in Engineering II (BME5104); Engineering Analysis for Regulatory Approval (BME4103); Fundamentals of Engineering (EI140);

Modules Taught

Term/Year	Module Title	Module Code
2020/2021	Fundamentals of Engineering	EI140
2023/2024	Engineering Group Project (Coordinator)	BME4106
2022/2023	Engineering Group Project (Coordinator)	BME4106
2023/2024	Biomedical Engineering Project (Coordinator)	BME4012
2023/2024	Biomedical Engineering Design II	BME3135
2023/2024	Finite Element Methods in Engineering II	BME5104
2022/2023	Biomedical Engineering Design II	BME3135
2021/2022	Fundamentals of Engineering	EI140
2020/2021	Engineering Analysis for Regulatory Approval	BME4103
2021/2022	Biomedical Engineering Design II	BME3135
2022/2023	Finite Element Methods in Engineering II	BME5104
2021/2022	Materials I (Lab Coordinator)	BME2100
2022/2023	Biomedical Engineering Project (Coordinator)	BME4102
2020/2021	Materials I (Lab Coordinator)	BME2100