Medicine

Dr Brendan Higgins

B.Sc, Ph.D

Biography

Dr. Brendan Higgins is Lecturer in Lung Biology in the Discipline of Physiology at the Human Biology Building (HBB), NUI Galway. He holds a BSc in Physiology (NUI Galway) and a PhD (2002) for a thesis entitled “An investigation of myo-inositol transport in mouse embryos and embryonic stem cells” (NUI Galway). As a post-doctoral researcher in the Discipline of Anaesthesiology, NUI Galway, he studied the efficacy of hypercapnia in the treatment of Acute Respiratory Distress Syndrome (ARDS). He was also involved in the utilisation of new medical devices for airway management as well as cardiovascular research studying the effects of anaesthetic agents on placenta chorionic plate arteries. Under the mentorship of Prof. John Laffey in Anaesthesiology, he studied novel therapeutic approaches in the treatment of ARDS and sepsis using a number of approaches including hypercapnia and gene therapy mediated by viral vectors, in cooperation with the Regenerative Medicine Institute (REMEDI) at NUI Galway, combining biochemical modifications and basic lung physiology. He was also heavily involved in a programme studying the translational therapeutic potential of mesenchymal stem cells in Ventilator Induced Lung Injury. In 2012, Dr Higgins was awarded a Post-Doctoral Translational Medicine research fellowship by the Health Research Board to study the potential of biomaterial nanosphere-mediated delivery of superoxide dismutase gene and sepsis-induced lung injury.
Since moving to his current role within the Discipline of Physiology at NUI Galway, Dr. Higgins has extended his interest in the field of drug delivery to the lung epithelium with an ongoing research in conjunction with Aerogen Inc., Galway. This also coincides with Dr. Higgins’ involvement in the CÚRAM research centre and the ongoing development of a novel recombinant superoxide dismutase fusion protein to improve drug retention time in the lung and therefore outcomes in ARDS and, potentially, other serious conditions. To date Dr. Higgins has co-authored over 25 papers in peer reviewed journals as well as numerous poster and conference presentations.

Peer Reviewed Journals

	Year	Publication
	(2003)	'Inositol transport in mouse oocytes and preimplantation embryos: effects of mouse strain, embryo stage, sodium and the hexose transport inhibitor, phloridzin' Higgins, BD;Kane, MT (2003) 'Inositol transport in mouse oocytes and preimplantation embryos: effects of mouse strain, embryo stage, sodium and the hexose transport inhibitor, phloridzin'. Reproduction, 125 :111-118 [Details]
	(2005)	'Inositol transport in mouse embryonic stem cells' Higgins, BD;Kane, MT (2005) 'Inositol transport in mouse embryonic stem cells'. Reproduction Fertility And Development, 17 :633-639 [Details]
	(2008)	'Hypercapnic acidosis attenuates severe acute bacterial pneumonia-induced lung injury by a neutrophil-independent mechanism' Chonghaile, MN;Higgins, BD;Costello, JF;Laffey, JG (2008) 'Hypercapnic acidosis attenuates severe acute bacterial pneumonia-induced lung injury by a neutrophil-independent mechanism'. Critical Care Medicine, 36 :3135-3144 [DOI] [Details]
	(2008)	'Sevoflurane and the feto-placental vasculature: The role of nitric oxide and vasoactive eicosanoids' Farragher, R;Maharaj, CH;Higgins, BD;Crowe, S;Burke, P;Laffey, CD;Flynn, NM;Laffey, JG (2008) 'Sevoflurane and the feto-placental vasculature: The role of nitric oxide and vasoactive eicosanoids'. Anesthesia And Analgesia, 107 :171-177 [DOI] [Details]
	(2009)	'Differential Effects of Buffered Hypercapnia versus Hypercapnic Acidosis on Shock and Lung Injury Induced by Systemic Sepsis' Higgins, BD;Costello, J;Contreras, M;Hassett, P;O'Toole, D;Laffey, JG (2009) 'Differential Effects of Buffered Hypercapnia versus Hypercapnic Acidosis on Shock and Lung Injury Induced by Systemic Sepsis'. Anesthesiology, 111 :1317-1326 [Details]
	(2009)	'Optimized Aerosol Delivery to a Mechanically Ventilated Rodent' MacLoughlin, RJ;Higgins, BD;Laffey, JG;O'Brien, T (2009) 'Optimized Aerosol Delivery to a Mechanically Ventilated Rodent'. Journal Of Aerosol Medicine And Pulmonary Drug Delivery, 22 :323-332 [DOI] [Details]
	(2009)	'Effects and mechanisms of action of sildenafil citrate in human chorionic arteries' Maharaj, CH;O'Toole, D;Lynch, T;Carney, J;Jarman, J;Higgins, BD;Morrison, JJ;Laffey, JG (2009) 'Effects and mechanisms of action of sildenafil citrate in human chorionic arteries'. Reproductive Biology And Endocrinology, 7 [DOI] [Details]
	(2011)	'Evolution of the Inflammatory and Fibroproliferative Responses during Resolution and Repair after Ventilator-induced Lung Injury in the Rat' Curley, GF;Contreras, M;Higgins, B;O'Kane, C;McAuley, DF;O'Toole, D;Laffey, JG (2011) 'Evolution of the Inflammatory and Fibroproliferative Responses during Resolution and Repair after Ventilator-induced Lung Injury in the Rat'. Anesthesiology, 115 :1022-1032 [DOI] [Details]
		'Permissive Hypercapnia' Hassett P, Higgins BD, O'Toole D, Laffey JG 'Permissive Hypercapnia'. Chapter accepted for publication, Italian Critical Care Book, [Details]
	(2015)	'Aerosol-Mediated Delivery of AAV2/6-I kappa B alpha Attenuates Lipopolysaccharide-Induced Acute Lung Injury in Rats' MacLoughlin, RJ,Higgins, BD,Devaney, J,O'Toole, D,Laffey, JG,O'Brien, T (2015) 'Aerosol-Mediated Delivery of AAV2/6-I kappa B alpha Attenuates Lipopolysaccharide-Induced Acute Lung Injury in Rats'. Human Gene Therapy, 26 :36-46 [DOI] [Details]
	(2014)	'Aerosol-mediated delivery of AAV2/6-IκBα attenuates lipopolysaccharide-induced acute lung injury in rats' MacLoughlin R, Higgins BD, Devaney J, O'Toole d, Laffey DG, O'Brien T. (2014) 'Aerosol-mediated delivery of AAV2/6-IκBα attenuates lipopolysaccharide-induced acute lung injury in rats'. Human Gene Therapy, [Details]
	(2012)	'Hypercapnic acidosis attenuates ventilation-induced lung injury by a nuclear factor-kappa B dependent mechanism' Contreras, M,Ansari, B,Curley, G,Higgins, BD,Hassett, P,O'Toole, D,Laffey, JG (2012) 'Hypercapnic acidosis attenuates ventilation-induced lung injury by a nuclear factor-kappa B dependent mechanism'. Critical Care Medicine, 40 :2622-2630 [DOI] [Details]
	(2011)	'Overexpression of pulmonary extracellular uperoxide dismutase attenuates endotoxin induced acute lung injury' Hassett P, Curley GF, Contreras M, Masterson C, Higgins BD, O'Brien T, Devaney J, O'Toole D, Laffey JG. (2011) 'Overexpression of pulmonary extracellular uperoxide dismutase attenuates endotoxin induced acute lung injury'. Intensive Care Medicine, 37 (10):1680-1687 [Details]
	(2011)	'Evolution of the Inflammatory and Fibroproliferative Responses during Resolution and Repair after Ventilator-induced Lung Injury in the Rat' Curley, GF,Contreras, M,Higgins, B,O'Kane, C,McAuley, DF,O'Toole, D,Laffey, JG (2011) 'Evolution of the Inflammatory and Fibroproliferative Responses during Resolution and Repair after Ventilator-induced Lung Injury in the Rat'. Anesthesiology, 115 :1022-1032 [DOI] [Details]
	(2010)	'Hypercapnia and acidosis in sepsis: a double-edged sword?' Curley G, Contreras MM, Nichol AD, Higgins BD, Laffey JG (2010) 'Hypercapnia and acidosis in sepsis: a double-edged sword?'. Anesthesiology, 112 (2):462-472 [DOI] [Details]
	(2009)	'Comparison of the Glidescope and Pentax AWS laryngoscopes to the Macintosh laryngoscope for use by advanced paramedics in easy and simulated difficult intubation' Nasim S, Maharaj CH, Malik MA, O' Donnell J, Higgins BD, Laffey JG (2009) 'Comparison of the Glidescope and Pentax AWS laryngoscopes to the Macintosh laryngoscope for use by advanced paramedics in easy and simulated difficult intubation'. BMC Emerg Med, 9 [DOI] [Details]
	(2009)	'Differential Effects of Buffered Hypercapnia versus Hypercapnic Acidosis on Shock and Lung Injury Induced by Systemic Sepsis' Higgins, BD,Costello, J,Contreras, M,Hassett, P,O'Toole, D,Laffey, JG (2009) 'Differential Effects of Buffered Hypercapnia versus Hypercapnic Acidosis on Shock and Lung Injury Induced by Systemic Sepsis'. Anesthesiology, 111 :1317-1326 [Details]
	(2009)	'Comparison of the Airtraq and Truview laryngoscopes to the Macintosh laryngoscope for use by Advanced Paramedics in easy and simulated difficult intubation in manikins' Nasim S, Maharaj CH, Butt I, Malik MA, O' Donnell J, Higgins BD, Harte BH, Laffey JG (2009) 'Comparison of the Airtraq and Truview laryngoscopes to the Macintosh laryngoscope for use by Advanced Paramedics in easy and simulated difficult intubation in manikins'. BMC Emerg Med, 9 [DOI] [Details]
	(2009)	'Role of potassium and calcium channels in sevoflurane-mediated vasodilation in the foeto-placental circulation' Jarman J, Maharaj CH, Higgins BD, Farragher RF, Laffey CD, Flynn NM, Laffey JG (2009) 'Role of potassium and calcium channels in sevoflurane-mediated vasodilation in the foeto-placental circulation'. BMC Anesthesiol, 9 [DOI] [Details]
	(2009)	'Hypercapnic acidosis attenuates shock and lung injury in early and prolonged systemic sepsis' Costello J, Higgins B, Contreras M, Chonghaile MN, Hassett P, O'Toole D, Laffey JG (2009) 'Hypercapnic acidosis attenuates shock and lung injury in early and prolonged systemic sepsis'. Critical Care Medicine, 37 (8):2412-2420 [DOI] [Details]
	(2009)	'A comparison of the Glidescope (R), Pentax AWS (R), and Macintosh laryngoscopes when used by novice personnel: a manikin study' Malik, MA,Hassett, P,Carney, J,Higgins, BD,Harte, BH,Laffey, JG (2009) 'A comparison of the Glidescope (R), Pentax AWS (R), and Macintosh laryngoscopes when used by novice personnel: a manikin study'. Canadian Journal Of Anaesthesia-Journal Canadien D Anesthesie, 56 :802-811 [DOI] [Details]
	(2009)	'Effects and mechanisms of action of sildenafil citrate in human chorionic arteries' Maharaj, CH,O'Toole, D,Lynch, T,Carney, J,Jarman, J,Higgins, BD,Morrison, JJ,Laffey, JG (2009) 'Effects and mechanisms of action of sildenafil citrate in human chorionic arteries'. Reproductive Biology And Endocrinology, 7 [DOI] [Details]
	(2009)	'Hypercapnic acidosis attenuates pulmonary epithelial wound repair by an NF-kappa B dependent mechanism' O'Toole, D,Hassett, P,Contreras, M,Higgins, BD,McKeown, STW,McAuley, DF,O'Brien, T,Laffey, JG (2009) 'Hypercapnic acidosis attenuates pulmonary epithelial wound repair by an NF-kappa B dependent mechanism'. Thorax, 64 :976-982 [DOI] [Details]
	(2009)	'Optimized Aerosol Delivery to a Mechanically Ventilated Rodent' MacLoughlin, RJ,Higgins, BD,Laffey, JG,O'Brien, T (2009) 'Optimized Aerosol Delivery to a Mechanically Ventilated Rodent'. Journal Of Aerosol Medicine And Pulmonary Drug Delivery, 22 :323-332 [DOI] [Details]
	(2009)	'A comparison of the Glidescope, Pentax AWS, and Macintosh laryngoscopes when used by novice personnel: a manikin study' Malik MA, Hassett P, Carney J, Higgins BD, Harte BH, Laffey JG (2009) 'A comparison of the Glidescope, Pentax AWS, and Macintosh laryngoscopes when used by novice personnel: a manikin study'. Canadian Journal Of Anaesthesia-Journal Canadien D Anesthesie, 56 (11):802-811 [DOI] [Details]
	(2008)	'Determination of the efficacy and side-effect profile of lower doses of Intrathecal Morphine in Patients undergoing Total Knee Replacement' Higgins BD, Costello J, Contreras M, Hassett P, O' Toole D, Laffey JG. (2008) 'Determination of the efficacy and side-effect profile of lower doses of Intrathecal Morphine in Patients undergoing Total Knee Replacement'. BMC Anesthesiology, 8 (5) [Details]
	(2008)	'Hypercapnic acidosis attenuates severe acute bacterial pneumonia-induced lung injury by a neutrophil-independent mechanism' Chonghaile, MN,Higgins, BD,Costello, JF,Laffey, JG (2008) 'Hypercapnic acidosis attenuates severe acute bacterial pneumonia-induced lung injury by a neutrophil-independent mechanism'. Critical Care Medicine, 36 :3135-3144 [DOI] [Details]
	(2008)	'Sevoflurane and the feto-placental vasculature: The role of nitric oxide and vasoactive eicosanoids' Farragher, R,Maharaj, CH,Higgins, BD,Crowe, S,Burke, P,Laffey, CD,Flynn, NM,Laffey, JG (2008) 'Sevoflurane and the feto-placental vasculature: The role of nitric oxide and vasoactive eicosanoids'. Anesthesia And Analgesia, 107 :171-177 [DOI] [Details]
	(2008)	'Hypercapnic acidosis attenuates lung injury induced by established bacterial pneumonia' Chonghaile MN, Higgins BD, Costello J, Laffey JG (2008) 'Hypercapnic acidosis attenuates lung injury induced by established bacterial pneumonia'. Anesthesiology, 109 (5):837-848 [DOI] [Details]
	(2008)	'A Comparison of Macintosh, Truview EV02â, Glidescope® and Airwayscope® Laryngoscopes in Patients with Cervical Spine Immobilization' Higgins BD, Costello J, Contreras M, Hassett P, O' Toole D, Laffey JG. (2008) 'A Comparison of Macintosh, Truview EV02â, Glidescope® and Airwayscope® Laryngoscopes in Patients with Cervical Spine Immobilization'. Br J Anaesth, 101 (5):723-730 [DOI] [Details]
	(2008)	'Hypertonic saline reduces inflammation and enhances the resolution of oleic acid induced acute lung injury' Kennedy MT, Higgins BD, Costello JF, Curtin WA, Laffey JG (2008) 'Hypertonic saline reduces inflammation and enhances the resolution of oleic acid induced acute lung injury'. BMC pulmonary medicine, 8 [DOI] [Details]
	(2007)	'Retention of tracheal intubation skills by novice personnel: a comparison of the Airtraq (R) and Macintosh laryngoscopes' Maharaj, CH,Costello, J,Higgins, BD,Harte, BH,Laffey, JG (2007) 'Retention of tracheal intubation skills by novice personnel: a comparison of the Airtraq (R) and Macintosh laryngoscopes'. Anaesthesia, 62 :272-278 [DOI] [Details]
	(2006)	'Evaluation of intubation using the Airtraq or Macintosh laryngoscope by anaesthetists in easy and simulated difficult laryngoscopy--a manikin study' Maharaj CH, Higgins BD, Harte BH, Laffey JG (2006) 'Evaluation of intubation using the Airtraq or Macintosh laryngoscope by anaesthetists in easy and simulated difficult laryngoscopy--a manikin study'. Anaesthesia, 61 (5):469-477 [DOI] [Details]
	(2006)	'Learning and performance of tracheal intubation by novice personnel: a comparison of the Airtraq (R) and Macintosh laryngoscope' Maharaj, CH,Costello, JF,Higgins, BD,Harte, BH,Laffey, JG (2006) 'Learning and performance of tracheal intubation by novice personnel: a comparison of the Airtraq (R) and Macintosh laryngoscope'. Anaesthesia, 61 :671-677 [DOI] [Details]
	(2006)	'Evaluation of ease of intubation with the Airtraq® or Macintosh laryngoscope by anaesthetists in easy and simulated difficult laryngoscopy – A manikin study' Maharaj CH, Higgins B, Harte BH, Laffey JG (2006) 'Evaluation of ease of intubation with the Airtraq® or Macintosh laryngoscope by anaesthetists in easy and simulated difficult laryngoscopy – A manikin study'. Anaesthesia, [Details]
	(2006)	'Tracheal intubation by inexperienced medical residents using the Airtraq and Macintosh laryngoscopes--a manikin study' Maharaj CH, Ni Chonghaile M, Higgins BD, Harte BH, Laffey JG (2006) 'Tracheal intubation by inexperienced medical residents using the Airtraq and Macintosh laryngoscopes--a manikin study'. American Journal Of Emergency Medicine, 24 (7):769-774 [DOI] [Details]
	(2006)	'Learning and performance of tracheal intubation by novice personnel: a comparison of the Airtraq and Macintosh laryngoscope' Maharaj CH, Costello JF, Higgins BD, Harte BH, Laffey JG (2006) 'Learning and performance of tracheal intubation by novice personnel: a comparison of the Airtraq and Macintosh laryngoscope'. Anaesthesia, 61 (7):671-677 [DOI] [Details]
	(2005)	'Inositol transport in mouse embryonic stem cells' Higgins, BD,Kane, MT (2005) 'Inositol transport in mouse embryonic stem cells'. Reproduction Fertility And Development, 17 :633-639 [Details]
	(2005)	'Bench-to-bedside review: Permissive hypercapnia' O'Croinin D, Ni Chonghaile M, Higgins B, Laffey JG (2005) 'Bench-to-bedside review: Permissive hypercapnia'. Critical care (London, England), 9 (1):51-59 [DOI] [Details]
	(2005)	'Permissive hypercapnia: role in protective lung ventilatory strategies' Ni Chonghaile M, Higgins B, Laffey JG (2005) 'Permissive hypercapnia: role in protective lung ventilatory strategies'. Critical care (London, England), 11 (1):56-62 [Details]
	(2003)	'Inositol transport in mouse oocytes and preimplantation embryos: effects of mouse strain, embryo stage, sodium and the hexose transport inhibitor, phloridzin' Higgins, BD,Kane, MT (2003) 'Inositol transport in mouse oocytes and preimplantation embryos: effects of mouse strain, embryo stage, sodium and the hexose transport inhibitor, phloridzin'. Reproduction, 125 :111-118 [Details]

Conference Publications

	Year	Publication
	(2008)	*ANESTHESIOLOGY* Chonghaile, MN;Higgins, BD;Costello, J;Laffey, JG (2008) Hypercapnic Acidosis Attenuates Lung Injury Induced by Established Bacterial Pneumonia ANESTHESIOLOGY , pp.837-848 [Details]
	(2009)	*CRITICAL CARE MEDICINE* Costello, J;Higgins, B;Contreras, M;Chonghaile, MN;Hassett, P;O'Toole, D;Laffey, JG (2009) Hypercapnic acidosis attenuates shock and lung injury in early and prolonged systemic sepsis CRITICAL CARE MEDICINE , pp.2412-2420 [DOI] [Details]
	(2011)	*INTENSIVE CARE MEDICINE* Hassett, P;Curley, GF;Contreras, M;Masterson, C;Higgins, BD;O'Brien, T;Devaney, J;O'Toole, D;Laffey, JG (2011) Overexpression of pulmonary extracellular superoxide dismutase attenuates endotoxin-induced acute lung injury INTENSIVE CARE MEDICINE , pp.1680-1687 [DOI] [Details]
	(2011)	*Overexpression of pulmonary extracellular superoxide dismutase attenuates endotoxin-induced acute lung injury* Hassett, P,Curley, GF,Contreras, M,Masterson, C,Higgins, BD,O'Brien, T,Devaney, J,O'Toole, D,Laffey, JG (2011) INTENSIVE CARE MEDICINE Overexpression of pulmonary extracellular superoxide dismutase attenuates endotoxin-induced acute lung injury , pp.1680-1687 [DOI] [Details]
	(2009)	*Hypercapnic acidosis attenuates shock and lung injury in early and prolonged systemic sepsis* Costello, J,Higgins, B,Contreras, M,Chonghaile, MN,Hassett, P,O'Toole, D,Laffey, JG (2009) CRITICAL CARE MEDICINE Hypercapnic acidosis attenuates shock and lung injury in early and prolonged systemic sepsis , pp.2412-2420 [DOI] [Details]
	(2008)	*Hypercapnic Acidosis Attenuates Lung Injury Induced by Established Bacterial Pneumonia* Chonghaile, MN,Higgins, BD,Costello, J,Laffey, JG (2008) ANESTHESIOLOGY Hypercapnic Acidosis Attenuates Lung Injury Induced by Established Bacterial Pneumonia , pp.837-848 [Details]

Abstract

	Year	Publication
	(2009)	INTRAPULMONARY DELIVERY OF EXTRACELLULAR SUPEROXIDE DISMUTASE AMELIORATES LIPO-POLYSACCHARIDE INDUCED LUNG INJURY IN RATS. Hassett, P,Curley, G,O'Toole, D,O'Higgins, B,Laffey, J (2009) INTRAPULMONARY DELIVERY OF EXTRACELLULAR SUPEROXIDE DISMUTASE AMELIORATES LIPO-POLYSACCHARIDE INDUCED LUNG INJURY IN RATS. Abstract [Details]
	(2008)	Aerosol delivery of rAAV pseudotypes 2, 2/5 and 2/6. ISGCT Annual Conference. MacLoughlin R, Higgins B, Laffey J, O'Brien T (2008) Aerosol delivery of rAAV pseudotypes 2, 2/5 and 2/6. ISGCT Annual Conference. UCC: Abstract [Details]
	(2007)	A systematic approach to maximising aerosol delivery of adeno-associated viral (AAV) vector to the lungs. British Association for Lung Research (BALR), 'Gene and Stem Cell Therapies for Lung Diseases', National University of Ireland, Maynooth, Ireland. MacLoughlin R, Higgins B, Laffey J, O'Brien T (2007) A systematic approach to maximising aerosol delivery of adeno-associated viral (AAV) vector to the lungs. British Association for Lung Research (BALR), 'Gene and Stem Cell Therapies for Lung Diseases', National University of Ireland, Maynooth, Ireland. Abstract [Details]
	(2007)	Optimization of aerosol delivery to the lungs of Sprague-Dawley rat, an in vitro study of aerosol performance. International Society for Aerosols in Medicine (ISAM), 16th Congress, Vinci Congress Center. MacLoughlin R, Higgins B, Laffey J, O' Brien T (2007) Optimization of aerosol delivery to the lungs of Sprague-Dawley rat, an in vitro study of aerosol performance. International Society for Aerosols in Medicine (ISAM), 16th Congress, Vinci Congress Center. Tours, France: Abstract [Details]

Meeting

	Year	Publication
	(2010)	Time Course Of Lung Injury, Inflammation, Repair And Fibrosis Following Ventilator Induced Lung Injury. Curley, GF,Contreras, M,Higgins, B,O'Toole, D,O'Kane, C,Laffey, J (2010) Time Course Of Lung Injury, Inflammation, Repair And Fibrosis Following Ventilator Induced Lung Injury. Meeting [Details]
	(2010)	Hypercapnic Acidosis Attenuates Moderate And Severe Ventilator Induced Lung Injury By An NF-kB Dependent Mechanism. Contreras, M,O'Toole, D,Higgins, B,Ansari, BM,Curley, GF,Masterson, C,Laffey, J (2010) Hypercapnic Acidosis Attenuates Moderate And Severe Ventilator Induced Lung Injury By An NF-kB Dependent Mechanism. Meeting [Details]
	(2010)	MESENCHYMAL STEM CELLS ENHANCE REPAIR FOLLOWING VENTILATOR INDUCED LUNG INJURY. Curley, GF,Contreras, M,Ansari, B,Masterson, C,McHale, P,Devaney, J,Higgins, BD,O'Toole, D,Laffey, JG (2010) MESENCHYMAL STEM CELLS ENHANCE REPAIR FOLLOWING VENTILATOR INDUCED LUNG INJURY. Meeting [Details]
	(2009)	Prolonged Hypercapnia Reduces the Severity of Acute Lung Injury in Chronic Polymicrobial Sepsis. Contreras, M,Costello, J,Higgins, B,O'Tool, D,Hassett, P,Laffey, JG (2009) Prolonged Hypercapnia Reduces the Severity of Acute Lung Injury in Chronic Polymicrobial Sepsis. Meeting [Details]
	(2009)	Molecular Effects of Hypercapnic Acidosis on the NF-kappa B Intracellular Signalling Pathway. O'Toole, DP,Hassett, PD,Leo, AM,Higgins, BD,Laffey, JG (2009) Molecular Effects of Hypercapnic Acidosis on the NF-kappa B Intracellular Signalling Pathway. Meeting [Details]
	(2009)	Hypercapnic Acidosis Inhibits TNF alpha Induced Wound Healing in a Lung Cell Culture Model. O'Toole, D,Hassett, P,Leo, A,Higgins, BD,Laffey, JG (2009) Hypercapnic Acidosis Inhibits TNF alpha Induced Wound Healing in a Lung Cell Culture Model. Meeting [Details]
	(2008)	Aerosol delivery of AAV5-gfp to the rodent lung. Mac Loughlin, R,Higgins, B,Laffey, J,O'Brien, T (2008) Aerosol delivery of AAV5-gfp to the rodent lung. Meeting [Details]

Reviews

	Year	Publication
	(2005)	Permissive hypercapnia: role in protective lung ventilatory strategies. Ni Chonghaile, M;Higgins, B;Laffey, JG (2005) Permissive hypercapnia: role in protective lung ventilatory strategies. PHILADELPHIA: Reviews [Details]
	(2005)	Bench-to-bedside review: Permissive hypercapnia. O'Croinin, D;Chonghaile, MN;Higgins, B;Laffey, JG (2005) Bench-to-bedside review: Permissive hypercapnia. LONDON: Reviews [DOI] [Details]
	(2010)	Hypercapnia and Acidosis in Sepsis A Double-edged Sword?. Curley, G;Contreras, M;Nichol, AD;Higgins, BD;Laffey, JG (2010) Hypercapnia and Acidosis in Sepsis A Double-edged Sword?. PHILADELPHIA: Reviews [Details]
	(2010)	Hypercapnia and Acidosis in Sepsis A Double-edged Sword?. Curley, G,Contreras, M,Nichol, AD,Higgins, BD,Laffey, JG (2010) Hypercapnia and Acidosis in Sepsis A Double-edged Sword?. Reviews [Details]
	(2005)	Bench-to-bedside review: Permissive hypercapnia. O'Croinin, D,Chonghaile, MN,Higgins, B,Laffey, JG (2005) Bench-to-bedside review: Permissive hypercapnia. Reviews [DOI] [Details]
	(2005)	Permissive hypercapnia: role in protective lung ventilatory strategies. Ni Chonghaile, M,Higgins, B,Laffey, JG (2005) Permissive hypercapnia: role in protective lung ventilatory strategies. Reviews [Details]