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Biological and Chemical Sciences

Dr Sheila Donnelly

BSc, PhD

Contact Details

Research Fellow
School of Natural Sciences
University of Galway
E: Sheila.Donnelly@universityofgalway.ie
 
researcher
 

Biography

A/Prof. Sheila Donnelly received her PhD in 1992, studying the neuro-immunology of viral infections, from Trinity College Dublin, under the supervision of Prof. Atkins. Then, a postdoctoral position with Prof. Mills at the National University of Ireland Maynooth followed, focusing primarily on understanding the neuro-immunological response to vaccination; investigating the links between the administration of whole cell vaccines and the induction of seizure behaviour. In 2001, she moved to Dublin City University, to work with Prof. John Dalton on the isolation and characterisation of immune modulating proteins secreted by helminth parasites. This research established her interest in understanding the host-parasite relationship, with a particular focus on the impacts to the host innate immune response. Following a move to the University of Technology Sydney, Australia in 2004, Sheila then established a research group, investigating the mechanisms by which helminth derived proteins and microRNAs regulate host immune cells; and applied this knowledge to develop novel therapeutics for the treatment of human immune-mediated disease. In 2023, Sheila re-joined Prof. Dalton at MPL, Galway to continue their long-standing collaboration. She remains an adjunct A/Prof. at UTS

Research Interests

Parasitology, The innate immune response, Host-parasite interactions, miRNA gene regulation during infection, helminth-derived therapeutics 

Peer Reviewed Journals

  Year Publication
(2024) 'The knowns and unknowns of helminth--host miRNA cross-kingdom communication'
Chowdhury, Sumaiya and Sais, Dayna and Donnelly, Sheila and Tran, Nham (2024) 'The knowns and unknowns of helminth--host miRNA cross-kingdom communication'. Trends in Parasitology, [Details]
(2024) 'The helminth derived peptide, FhHDM-1, reverses the trained phenotype of NOD bone marrow derived macrophages to regulate pro-inflammatory responses'
Loli Quinteros S, O'Brien B, Donnelly S (2024) 'The helminth derived peptide, FhHDM-1, reverses the trained phenotype of NOD bone marrow derived macrophages to regulate pro-inflammatory responses'. European Journal Of Immunology, [Details]
(2024) 'Exploring the utility of circulating miRNAs as diagnostic biomarkers of fasciolosis'
Chowdhury, Sumaiya and Ricafrente, Alison and Cwiklinski, Krystyna and Sais, Dayna and Dalton, John P and Tran, Nham and Donnelly, Sheila (2024) 'Exploring the utility of circulating miRNAs as diagnostic biomarkers of fasciolosis'. Scientific Reports, 14 (1) [Details]
(2024) 'The parasite-derived peptide FhHDM-1 induces the differential expression of miRNAs to regulate gene networks that mediate ß-cell survival against pro-inflammatory cytokine challenge'
Camaya I, O'Brien B, Donnelly S. (2024) 'The parasite-derived peptide FhHDM-1 induces the differential expression of miRNAs to regulate gene networks that mediate ß-cell survival against pro-inflammatory cytokine challenge'. Journal Of Diabetes Research, [Details]
(2023) 'How do parasitic worms prevent diabetes? An exploration of their influence on macrophage and beta-cell crosstalk'
Camaya, Inah, O'Brien, Bronwyn and Donnelly, Sheila (2023) 'How do parasitic worms prevent diabetes? An exploration of their influence on macrophage and beta-cell crosstalk'. Frontiers In Endocrinology, 14 [Details]
(2023) 'The helminth derived peptide FhHDM-1 redirects macrophage metabolism towards glutaminolysis to regulate the pro-inflammatory response'
Quinteros, Susel Loli and von Krusenstiern, Eliana and Snyder, Nathaniel W and Tanaka, Akane and O’Brien, Bronwyn and Donnelly, Sheila (2023) 'The helminth derived peptide FhHDM-1 redirects macrophage metabolism towards glutaminolysis to regulate the pro-inflammatory response'. Frontiers in Immunology, 14 [Details]
(2023) 'Macrophage migration inhibitory factor promotes glucocorticoid resistance of neutrophilic inflammation in a murine model of severe asthma'
Allam, Venkata Sita Rama Raju and Pavlidis, Stelios and Liu, Gang and Kermani, Nazanin Zounemat and Simpson, Jennifer and To, Joyce and Donnelly, Sheila and Guo, Yi-Ke and Hansbro, Philip M and Phipps, Simon and others (2023) 'Macrophage migration inhibitory factor promotes glucocorticoid resistance of neutrophilic inflammation in a murine model of severe asthma'. Thorax, 78 (7):661-673 [Details]
(2022) 'Targeting the PI3K/Akt signaling pathway in pancreatic $\beta$-cells to enhance their survival and function: an emerging therapeutic strategy for type 1 diabetes'
Camaya, Inah and Donnelly, Sheila and O'Brien, Bronwyn (2022) 'Targeting the PI3K/Akt signaling pathway in pancreatic $\beta$-cells to enhance their survival and function: an emerging therapeutic strategy for type 1 diabetes'. Journal of Diabetes, 14 (4):247-260 [Details]
(2022) 'Exploring the role of macrophages in determining the pathogenesis of liver fluke infection'
Quinteros, Susel Loli and O'Brien, Bronwyn and Donnelly, Sheila (2022) 'Exploring the role of macrophages in determining the pathogenesis of liver fluke infection'. Parasitology, 149 (10):1364-1373 [Details]
(2022) 'Stage-specific miRNAs regulate gene expression associated with growth, development and parasite-host interaction during the intra-mammalian migration of the zoonotic helminth parasite Fasciola hepatica'
Ricafrente, Alison and Cwiklinski, Krystyna and Nguyen, Hieu and Dalton, John P and Tran, Nham and Donnelly, Sheila (2022) 'Stage-specific miRNAs regulate gene expression associated with growth, development and parasite-host interaction during the intra-mammalian migration of the zoonotic helminth parasite Fasciola hepatica'. BMC genomics, 23 (1) [Details]
(2021) 'Complementary transcriptomic and proteomic analyses reveal the cellular and molecular processes that drive growth and development of Fasciola hepatica in the host liver'
Cwiklinski, Krystyna and Robinson, Mark W and Donnelly, Sheila and Dalton, John P (2021) 'Complementary transcriptomic and proteomic analyses reveal the cellular and molecular processes that drive growth and development of Fasciola hepatica in the host liver'. BMC genomics, 22 :1-16 [Details]
(2021) 'Commandeering the mammalian Ago2 miRNA network: a newly discovered mechanism of helminth immunomodulation'
Donnelly, Sheila and Tran, Nham (2021) 'Commandeering the mammalian Ago2 miRNA network: a newly discovered mechanism of helminth immunomodulation'. Trends in Parasitology, 37 (12):1031-1033 [Details]
(2021) 'Fasciola hepatica hijacks host macrophage miRNA machinery to modulate early innate immune responses'
Tran, Nham and Ricafrente, Alison and To, Joyce and Lund, Maria and Marques, Tania M and Gama-Carvalho, Margarida and Cwiklinski, Krystyna and Dalton, John P and Donnelly, Sheila (2021) 'Fasciola hepatica hijacks host macrophage miRNA machinery to modulate early innate immune responses'. Scientific reports, 11 (1) [Details]
(2021) 'The parasite-derived peptide FhHDM-1 activates the PI3K/Akt pathway to prevent cytokine-induced apoptosis of $\beta$-cells'
Camaya, Inah and Mok, Tsz Y and Lund, Maria and To, Joyce and Braidy, Nady and Robinson, Mark W and Santos, Jerran and O’Brien, Bronwyn and Donnelly, Sheila (2021) 'The parasite-derived peptide FhHDM-1 activates the PI3K/Akt pathway to prevent cytokine-induced apoptosis of $\beta$-cells'. Journal of Molecular Medicine, 99 (11):1605-1621 [Details]
(2021) 'An evaluation of the Fasciola hepatica miRnome predicts a targeted regulation of mammalian innate immune responses'
Ricafrente, Alison and Nguyen, Hieu and Tran, Nham and Donnelly, Sheila (2021) 'An evaluation of the Fasciola hepatica miRnome predicts a targeted regulation of mammalian innate immune responses'. Frontiers in Immunology, 11 [Details]
(2021) 'RAGE and TLR4 differentially regulate airway hyperresponsiveness: Implications for COPD'
Allam, Venkata Sita Rama Raju and Faiz, Alen and Lam, Maggie and Rathnayake, Senani NH and Ditz, Benedikt and Pouwels, Simon D and Brandsma, Corry-Anke and Timens, Wim and Hiemstra, Pieter S and Tew, Gaik W and others (2021) 'RAGE and TLR4 differentially regulate airway hyperresponsiveness: Implications for COPD'. Allergy, 76 (4):1123-1135 [Details]
(2021) 'The impact of helminth infection on the incidence of metabolic syndrome: A systematic review and meta-analysis'
Rennie, Claire and Fernandez, Ritin and Donnelly, Sheila and McGrath, Kristine CY (2021) 'The impact of helminth infection on the incidence of metabolic syndrome: A systematic review and meta-analysis'. Frontiers in Endocrinology, 12 [Details]
(2020) 'Schistosoma mansoni immunomodulatory molecule Sm16/SPO-1/SmSLP is a member of the trematode-specific helminth defence molecules (HDMs)'
Shiels, Jenna and Cwiklinski, Krystyna and Alvarado, Raquel and Thivierge, Karine and Cotton, Sophie and Gonzales Santana, Bibiana and To, Joyce and Donnelly, Sheila and Taggart, Clifford C and Weldon, Sinead and others (2020) 'Schistosoma mansoni immunomodulatory molecule Sm16/SPO-1/SmSLP is a member of the trematode-specific helminth defence molecules (HDMs)'. PLoS neglected tropical diseases, 14 (7) [Details]
(2020) 'Effectiveness of helminth therapy in the prevention of allograft rejection: a systematic review of allogeneic transplantation'
Kiss, Michelle and Burns, Heather and Donnelly, Sheila and Hawthorne, Wayne J (2020) 'Effectiveness of helminth therapy in the prevention of allograft rejection: a systematic review of allogeneic transplantation'. Frontiers in immunology, 11 [Details]
(2019) 'The cathepsin-like cysteine peptidases of trematodes of the genus Fasciola'
Cwiklinski, Krystyna and Donnelly, Sheila and Drysdale, Orla and Jewhurst, Heather and Smith, David and Verissimo, Carolina De Marco and Pritsch, Izanara C and O'Neill, Sandra and Dalton, John P and Robinson, Mark W (2019) 'The cathepsin-like cysteine peptidases of trematodes of the genus Fasciola'. Advances in parasitology, 104 :113-164 [Details]
(2018) 'The parasitic 68-mer peptide FhHDM-1 inhibits mixed granulocytic inflammation and airway hyperreactivity in experimental asthma'
Tanaka, Akane and Allam, Venkata Sita Rama Raju and Simpson, Jennifer and Tiberti, Natalia and Shiels, Jenna and To, Joyce and Lund, Maria and Combes, Valery and Weldon, Sinead and Taggart, Cliff and others (2018) 'The parasitic 68-mer peptide FhHDM-1 inhibits mixed granulocytic inflammation and airway hyperreactivity in experimental asthma'. Journal of Allergy and Clinical Immunology, 141 (6):2316-2319 [Details]
(2018) 'Infection by the helminth parasite Fasciola hepatica requires rapid regulation of metabolic, virulence, and invasive factors to adjust to its mammalian host'
Cwiklinski, Krystyna and Jewhurst, Heather and McVeigh, Paul and Barbour, Tara and Maule, Aaron G and Tort, Jose and O'Neill, Sandra M and Robinson, Mark W and Donnelly, Sheila and Dalton, John P (2018) 'Infection by the helminth parasite Fasciola hepatica requires rapid regulation of metabolic, virulence, and invasive factors to adjust to its mammalian host'. Molecular \& Cellular Proteomics, 17 (4):792-809 [Details]
(2018) 'Proteomic analysis of extracellular HMGB1 identifies binding partners and exposes its potential role in airway epithelial cell homeostasis'
Wong, Sharon L and To, Joyce and Santos, Jerran and Allam, Venkata Sita Rama Raju and Dalton, John P and Djordjevic, Steven P and Donnelly, Sheila and Padula, Matthew P and Sukkar, Maria B (2018) 'Proteomic analysis of extracellular HMGB1 identifies binding partners and exposes its potential role in airway epithelial cell homeostasis'. Journal of proteome research, 17 (1):33-45 [Details]
(2017) 'Novel therapeutics for multiple sclerosis designed by parasitic worms'
Dixit, Aakanksha and Tanaka, Akane and Greer, Judith M and Donnelly, Sheila (2017) 'Novel therapeutics for multiple sclerosis designed by parasitic worms'. International Journal of Molecular Sciences, 18 (10) [Details]
(2017) 'Immune signatures of pathogenesis in the peritoneal compartment during early infection of sheep with Fasciola hepatica'
Ruiz-Campillo, Maria Teresa and Molina Hernandez, Veronica and Escamilla, Alejandro and Stevenson, Michael and Perez, Jose and Martinez-Moreno, Alvaro and Donnelly, Sheila and Dalton, John P and Cwiklinski, Krystyna (2017) 'Immune signatures of pathogenesis in the peritoneal compartment during early infection of sheep with Fasciola hepatica'. Scientific reports, 7 (1) [Details]
(2017) 'Targeting the master regulator mTOR: a new approach to prevent the neurological of consequences of parasitic infections?'
Donnelly, Sheila and Huston, Wilhelmina M and Johnson, Michael and Tiberti, Natalia and Saunders, Bernadette and O’Brien, Bronwyn and Burke, Catherine and Labbate, Maurizio and Combes, Valery (2017) 'Targeting the master regulator mTOR: a new approach to prevent the neurological of consequences of parasitic infections?'. Parasites \& vectors, 10 :1-6 [Details]
(2017) 'The immune modulatory peptide FhHDM-1 secreted by the helminth Fasciola hepatica prevents NLRP3 inflammasome activation by inhibiting endolysosomal acidification in macrophages'
Alvarado, Raquel and To, Joyce and Lund, Maria E and Pinar, Anita and Mansell, Ashley and Robinson, Mark W and O'Brien, Bronwyn A and Dalton, John P and Donnelly, Sheila (2017) 'The immune modulatory peptide FhHDM-1 secreted by the helminth Fasciola hepatica prevents NLRP3 inflammasome activation by inhibiting endolysosomal acidification in macrophages'. The FASEB Journal, 31 (1):85-95 [Details]
(2017) 'Selection of reliable reference genes for the normalisation of gene expression levels following time course LPS stimulation of murine bone marrow derived macrophages'
Tanaka, Akane and To, Joyce and O’Brien, Bronwyn and Donnelly, Sheila and Lund, Maria (2017) 'Selection of reliable reference genes for the normalisation of gene expression levels following time course LPS stimulation of murine bone marrow derived macrophages'. BMC immunology, 18 :1-12 [Details]
(2016) 'A prospective view of animal and human Fasciolosis'
Cwiklinski, K and O'neill, SM and Donnelly, S and Dalton, JP (2016) 'A prospective view of animal and human Fasciolosis'. Parasite immunology, 38 (9):558-568 [Details]
(2016) 'A parasite-derived 68-mer peptide ameliorates autoimmune disease in murine models of Type 1 diabetes and multiple sclerosis'
Lund, Maria E and Greer, Judith and Dixit, Aakanksha and Alvarado, Raquel and McCauley-Winter, Padraig and To, Joyce and Tanaka, Akane and Hutchinson, Andrew T and Robinson, Mark W and Simpson, Ann M and others (2016) 'A parasite-derived 68-mer peptide ameliorates autoimmune disease in murine models of Type 1 diabetes and multiple sclerosis'. Scientific Reports, 6 (1) [Details]
(2016) 'The choice of phorbol 12-myristate 13-acetate differentiation protocol influences the response of THP-1 macrophages to a pro-inflammatory stimulus'
Lund, Maria E and To, Joyce and O'Brien, Bronwyn A and Donnelly, Sheila (2016) 'The choice of phorbol 12-myristate 13-acetate differentiation protocol influences the response of THP-1 macrophages to a pro-inflammatory stimulus'. Journal of immunological methods, 430 :64-70 [Details]
(2015) 'Fasciola hepatica vaccine: we may not be there yet but we’re on the right road'
Molina-Hern\'andez, Ver\'onica and Mulcahy, Grace and P\'erez, Jose and Mart\'\inez-Moreno, \'Alvaro and Donnelly, Sheila and O’Neill, Sandra M and Dalton, John P and Cwiklinski, Krystyna (2015) 'Fasciola hepatica vaccine: we may not be there yet but we’re on the right road'. Veterinary parasitology, 208 (1-2):101-111 [Details]
(2015) 'A parasitic helminth-derived peptide that targets the macrophage lysosome is a novel therapeutic option for autoimmune disease'
Alvarado, Raquel and O’Brien, Bronwyn and Tanaka, Akane and Dalton, John P and Donnelly, Sheila (2015) 'A parasitic helminth-derived peptide that targets the macrophage lysosome is a novel therapeutic option for autoimmune disease'. Immunobiology, 220 (2):262-269 [Details]
(2014) 'Cysteine peptidases as schistosomiasis vaccines with inbuilt adjuvanticity'
El Ridi, Rashika and Tallima, Hatem and Selim, Sahar and Donnelly, Sheila and Cotton, Sophie and Gonzales Santana, Bibiana and Dalton, John P (2014) 'Cysteine peptidases as schistosomiasis vaccines with inbuilt adjuvanticity'. PloS one, 9 (1) [Details]
(2014) 'Mechanisms of Immune Modulation by Fasciola hepatica: the Impact of Innate Immune Cells on the Developing Adaptive Immune Response'
O’Neill, Sandra M and Donnelly, Sheila (2014) 'Mechanisms of Immune Modulation by Fasciola hepatica: the Impact of Innate Immune Cells on the Developing Adaptive Immune Response'. Immunity to Helminths and Novel Therapeutic Approaches, 2 [Details]
(2014) 'Fasciola hepatica tegumental antigens indirectly induce an M2 macrophage-like phenotype in vivo'
Adams, PN and Aldridge, A and Vukman, KV and Donnelly, S and O'Neill, SM (2014) 'Fasciola hepatica tegumental antigens indirectly induce an M2 macrophage-like phenotype in vivo'. Parasite immunology, 36 (10):531-539 [Details]
(2014) 'Secreted proteins from the helminth Fasciola hepatica inhibit the initiation of autoreactive T cell responses and prevent diabetes in the NOD mouse'
Lund, Maria E and O'Brien, Bronwyn A and Hutchinson, Andrew T and Robinson, Mark W and Simpson, Ann M and Dalton, John P and Donnelly, Sheila (2014) 'Secreted proteins from the helminth Fasciola hepatica inhibit the initiation of autoreactive T cell responses and prevent diabetes in the NOD mouse'. PloS one, 9 (1) [Details]
(2014) 'Induction of protective immune responses against schistosomiasis using functionally active cysteine peptidases'
El Ridi, Rashika and Tallima, Hatem and Dalton, John P and Donnelly, Sheila (2014) 'Induction of protective immune responses against schistosomiasis using functionally active cysteine peptidases'. Frontiers in genetics, 5 [Details]
(2013) 'Immunomodulatory molecules of Fasciola hepatica: candidates for both vaccine and immunotherapeutic development'
Dalton, John P and Robinson, Mark W and Mulcahy, Grace and O’Neill, Sandra M and Donnelly, Sheila (2013) 'Immunomodulatory molecules of Fasciola hepatica: candidates for both vaccine and immunotherapeutic development'. Veterinary parasitology, 195 (3-4):272-285 [Details]
(2013) 'Cathelicidin-like helminth defence molecules (HDMs): absence of cytotoxic, anti-microbial and anti-protozoan activities imply a specific adaptation to immune modulation'
Thivierge, Karine and Cotton, Sophie and Schaefer, Deborah A and Riggs, Michael W and To, Joyce and Lund, Maria E and Robinson, Mark W and Dalton, John P and Donnelly, Sheila M (2013) 'Cathelicidin-like helminth defence molecules (HDMs): absence of cytotoxic, anti-microbial and anti-protozoan activities imply a specific adaptation to immune modulation'. PLoS neglected tropical diseases, 7 (7) [Details]
(2013) 'Fasciola hepatica: the therapeutic potential of a worm secretome'
Robinson, Mark W and Dalton, John P and O’Brien, Bronwyn A and Donnelly, Sheila (2013) 'Fasciola hepatica: the therapeutic potential of a worm secretome'. International journal for parasitology, 43 (3-4):283-291 [Details]
(2013) 'Helminth defence molecules; immunomodulators designed by parasites!'
Robinson, Mark W and Donnelly, Sheila and Dalton, John P (2013) 'Helminth defence molecules; immunomodulators designed by parasites!'. Frontiers In Microbiology, [Details]
(2012) 'Defense peptides secreted by helminth pathogens: antimicrobial and/or immunomodulator molecules?'
Cotton, Sophie and Donnelly, Sheila and Robinson, Mark W and Dalton, John P and Thivierge, Karine (2012) 'Defense peptides secreted by helminth pathogens: antimicrobial and/or immunomodulator molecules?'. Frontiers in immunology, 3 [Details]
(2012) 'A helminth cathelicidin-like protein suppresses antigen processing and presentation in macrophages via inhibition of lysosomal vATPase'
Robinson, Mark W and Alvarado, Raquel and To, Joyce and Hutchinson, Andrew T and Dowdell, Stephanie N and Lund, Maria and Turnbull, Lynne and Whitchurch, Cynthia B and O'Brien, Bronwyn A and Dalton, John P and others (2012) 'A helminth cathelicidin-like protein suppresses antigen processing and presentation in macrophages via inhibition of lysosomal vATPase'. The FASEB Journal, 26 (11):4614-4627 [Details]
(2012) 'Mechanisms of Immune Modulation by Fasciola hepatica: Importance for Vaccine Development and for Novel Immunotherapeutics'
Robinson, Mark W and Dalton, John P and O'Neill, Sandra M and Donnelly, Sheila M (2012) 'Mechanisms of Immune Modulation by Fasciola hepatica: Importance for Vaccine Development and for Novel Immunotherapeutics'. Parasitic Helminths: Targets, Screens, Drugs and Vaccines, :451-463 [Details]
(2012) 'Antimicrobial peptides: utility players in innate immunity'
Robinson, Mark W and Hutchinson, Andrew T and Donnelly, Sheila (2012) 'Antimicrobial peptides: utility players in innate immunity'. Frontiers In Immunology, [Details]
(2011) 'How pathogen-derived cysteine proteases modulate host immune responses'
Donnelly, Sheila and Dalton, John P and Robinson, Mark W (2011) 'How pathogen-derived cysteine proteases modulate host immune responses'. Cysteine Proteases of Pathogenic Organisms, :192-207 [Details]
(2011) 'A family of helminth molecules that modulate innate cell responses via molecular mimicry of host antimicrobial peptides'
Robinson, Mark W and Donnelly, Sheila and Hutchinson, Andrew T and To, Joyce and Taylor, Nicole L and Norton, Raymond S and Perugini, Matthew A and Dalton, John P (2011) 'A family of helminth molecules that modulate innate cell responses via molecular mimicry of host antimicrobial peptides'. PLoS pathogens, 7 (5) [Details]
(2010) 'TRANSCRIPTIONAL PROFILING OF SCHISTOSOMA JAPONICUM-STIMULATED ALTERNATIVELY ACTIVATED MACROPHAGES'
Burke, Melissa L and Donnelly, Sheila and McManus, Donald P and Dalton, John and Gobert, Geoffrey N (2010) 'TRANSCRIPTIONAL PROFILING OF SCHISTOSOMA JAPONICUM-STIMULATED ALTERNATIVELY ACTIVATED MACROPHAGES'. AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 83 :124-124 [Details]
(2010) 'Major secretory antigens of the helminth Fasciola hepatica activate a suppressive dendritic cell phenotype that attenuates Th17 cells but fails to activate Th2 immune responses'
Dowling, David J and Hamilton, Clare M and Donnelly, Sheila and La Course, James and Brophy, Peter M and Dalton, John and O'Neill, Sandra M (2010) 'Major secretory antigens of the helminth Fasciola hepatica activate a suppressive dendritic cell phenotype that attenuates Th17 cells but fails to activate Th2 immune responses'. Infection and immunity, 78 (2):793-801 [Details]
(2010) 'Worm secretory molecules are causing alarm'
Robinson, Mark W and Hutchinson, Andrew T and Donnelly, Sheila and Dalton, John P (2010) 'Worm secretory molecules are causing alarm'. Trends in parasitology, 26 (8):371-372 [Details]
(2010) 'Helminth cysteine proteases inhibit TRIF-dependent activation of macrophages via degradation of TLR3'
Donnelly, Sheila and O’Neill, Sandra M and Stack, Colin M and Robinson, Mark W and Turnbull, Lynne and Whitchurch, Cynthia and Dalton, John P (2010) 'Helminth cysteine proteases inhibit TRIF-dependent activation of macrophages via degradation of TLR3'. Journal of Biological Chemistry, 285 (5):3383-3392 [Details]
(2010) 'Peroxiredoxin: a central player in immune modulation'
Robinson, MW and Hutchinson, AT and Dalton, JP and Donnelly, S (2010) 'Peroxiredoxin: a central player in immune modulation'. Parasite immunology, 32 (5):305-313 [Details]
(2010) 'Protection of cattle against a natural infection of Fasciola hepatica by vaccination with recombinant cathepsin L1 (rFhCL1)'
Golden, Olwen and Flynn, Robin J and Read, C and Sekiya, Mary and Donnelly, SM and Stack, C and Dalton, John P and Mulcahy, Grace (2010) 'Protection of cattle against a natural infection of Fasciola hepatica by vaccination with recombinant cathepsin L1 (rFhCL1)'. Vaccine, 28 (34):5551-5557 [Details]
(2009) 'The M17 leucine aminopeptidase of the malaria parasite Plasmodium falciparum: importance of active site metal ions in the binding of substrates and inhibitors'
Maric, Selma and Donnelly, Sheila M and Robinson, Mark W and Skinner-Adams, Tina and Trenholme, Katharine R and Gardiner, Donald L and Dalton, John P and Stack, Colin M and Lowther, Jonathan (2009) 'The M17 leucine aminopeptidase of the malaria parasite Plasmodium falciparum: importance of active site metal ions in the binding of substrates and inhibitors'. Biochemistry, 48 (23):5435-5439 [Details]
(2009) 'Immunological interactions between 2 common pathogens, Th1-inducing protozoan Toxoplasma gondii and the Th2-inducing helminth Fasciola hepatica'
Miller, Catherine MD and Smith, Nicholas C and Ikin, Rowan J and Boulter, Nicola R and Dalton, John P and Donnelly, Sheila (2009) 'Immunological interactions between 2 common pathogens, Th1-inducing protozoan Toxoplasma gondii and the Th2-inducing helminth Fasciola hepatica'. PLoS One, 4 (5) [Details]
(2009) 'The enigmatic asparaginyl endopeptidase of helminth parasites'
Dalton, John P and Brindley, Paul J and Donnelly, Sheila and Robinson, Mark W (2009) 'The enigmatic asparaginyl endopeptidase of helminth parasites'. Trends in parasitology, 25 (2):59-61 [Details]
(2009) 'Structural basis for the inhibition of the essential Plasmodium falciparum M1 neutral aminopeptidase'
McGowan, Sheena and Porter, Corrine J and Lowther, Jonathan and Stack, Colin M and Golding, Sarah J and Skinner-Adams, Tina S and Trenholme, Katharine R and Teuscher, Franka and Donnelly, Sheila M and Grembecka, Jolanta and others (2009) 'Structural basis for the inhibition of the essential Plasmodium falciparum M1 neutral aminopeptidase'. Proceedings of the National Academy of Sciences, 106 (8):2537-2542 [Details]
(2009) 'The importance of pH in regulating the function of the Fasciola hepatica cathepsin L1 cysteine protease'
Lowther, Jonathan and Robinson, Mark W and Donnelly, Sheila M and Xu, Weibo and Stack, Colin M and Matthews, Jacqueline M and Dalton, John P (2009) 'The importance of pH in regulating the function of the Fasciola hepatica cathepsin L1 cysteine protease'. PLoS neglected tropical diseases, 3 (1) [Details]
(2009) 'An integrated transcriptomics and proteomics analysis of the secretome of the helminth pathogen Fasciola hepatica: proteins associated with invasion and infection of the mammalian host'
Robinson, Mark W and Menon, Ranjeeta and Donnelly, Sheila M and Dalton, John P and Ranganathan, Shoba (2009) 'An integrated transcriptomics and proteomics analysis of the secretome of the helminth pathogen Fasciola hepatica: proteins associated with invasion and infection of the mammalian host'. Molecular \& Cellular Proteomics, 8 (8):1891-1907 [Details]
(2009) 'Selective induction of the Notch ligand Jagged-1 in macrophages by soluble egg antigen from Schistosoma mansoni involves ERK signalling'
Goh, Felicia and Irvine, Katharine M and Lovelace, Erica and Donnelly, Sheila and Jones, Malcolm K and Brion, Kristian and Hume, David A and Kotze, Andrew C and Dalton, John P and Ingham, Aaron and others (2009) 'Selective induction of the Notch ligand Jagged-1 in macrophages by soluble egg antigen from Schistosoma mansoni involves ERK signalling'. Immunology, 127 (3):326-337 [Details]
(2008) 'Structural and functional relationships in the virulence-associated cathepsin L proteases of the parasitic liver fluke, Fasciola hepatica'
Stack, Colin M and Caffrey, Conor R and Donnelly, Sheila M and Seshaadri, Amritha and Lowther, Jonathan and Tort, Jose F and Collins, Peter R and Robinson, Mark W and Xu, Weibo and McKerrow, James H and others (2008) 'Structural and functional relationships in the virulence-associated cathepsin L proteases of the parasitic liver fluke, Fasciola hepatica'. Journal of Biological Chemistry, 283 (15):9896-9908 [Details]
(2008) 'Proteomics and phylogenetic analysis of the cathepsin L protease family of the helminth pathogen Fasciola hepatica: expansion of a repertoire of virulence-associated factors'
Robinson, Mark W and Tort, Jose F and Lowther, Jonathan and Donnelly, Sheila M and Wong, Emily and Xu, Weibo and Stack, Colin M and Padula, Matthew and Herbert, Ben and Dalton, John P (2008) 'Proteomics and phylogenetic analysis of the cathepsin L protease family of the helminth pathogen Fasciola hepatica: expansion of a repertoire of virulence-associated factors'. Molecular \& Cellular Proteomics, 7 (6):1111-1123 [Details]
(2008) 'Helminth 2-Cys peroxiredoxin drives Th2 responses through a mechanism involving alternatively activated macrophages'
Donnelly, Sheila and Stack, Colin M and O'Neill, Sandra M and Sayed, Ahmed A and Williams, David L and Dalton, John P (2008) 'Helminth 2-Cys peroxiredoxin drives Th2 responses through a mechanism involving alternatively activated macrophages'. The FASEB Journal, 22 (11) [Details]
(2008) 'Helminth pathogen cathepsin proteases: it’sa family affair'
Robinson, Mark W and Dalton, John P and Donnelly, Sheila (2008) 'Helminth pathogen cathepsin proteases: it’sa family affair'. Trends in biochemical sciences, 33 (12):601-608 [Details]
(2007) 'Characterization of the Plasmodium falciparum M17 leucyl aminopeptidase: a protease involved in amino acid regulation with potential for antimalarial drug development'
Stack, Colin M and Lowther, Jonathan and Cunningham, Eithne and Donnelly, Sheila and Gardiner, Donald L and Trenholme, Katharine R and Skinner-Adams, Tina S and Teuscher, Franka and Grembecka, Jolanta and Mucha, Artur and others (2007) 'Characterization of the Plasmodium falciparum M17 leucyl aminopeptidase: a protease involved in amino acid regulation with potential for antimalarial drug development'. Journal of Biological Chemistry, 282 (3):2069-2080 [Details]
(2007) 'Squamous cell carcinoma antigen 1 is an inhibitor of parasite-derived cysteine proteases'
Kanaji, Sachiko and Tanaka, Yoko and Sakata, Yasuhisa and Takeshita, Kohei and Arima, Kazuhiko and Ohta, Shoichiro and Hansell, Elizabeth J and Caffrey, Conor and Mottram, Jeremy C and Lowther, Jonathan and others (2007) 'Squamous cell carcinoma antigen 1 is an inhibitor of parasite-derived cysteine proteases'. FEBS letters, 581 (22):4260-4264 [Details]
(2007) 'The M18 aspartyl aminopeptidase of the human malaria parasite Plasmodium falciparum'
Teuscher, Franka and Lowther, Jonathan and Skinner-Adams, Tina S and Spielmann, Tobias and Dixon, Matthew WA and Stack, Colin M and Donnelly, Sheila and Mucha, Artur and Kafarski, Pawe\l and Vassiliou, Stamatia and others (2007) 'The M18 aspartyl aminopeptidase of the human malaria parasite Plasmodium falciparum'. Journal of Biological Chemistry, 282 (42):30817-30826 [Details]
(2007) 'The major secreted cathepsin L1 protease of the liver fluke, Fasciola hepatica: a Leu-12 to Pro-12 replacement in the nonconserved C-terminal region of the prosegment prevents complete enzyme autoactivation and allows definition of the molecular events in prosegment removal'
Stack, Colin M and Donnelly, Sheila and Lowther, Jonathan and Xu, Weibo and Collins, Peter R and Brinen, Linda S and Dalton, John P (2007) 'The major secreted cathepsin L1 protease of the liver fluke, Fasciola hepatica: a Leu-12 to Pro-12 replacement in the nonconserved C-terminal region of the prosegment prevents complete enzyme autoactivation and allows definition of the molecular events in prosegment removal'. Journal of Biological Chemistry, 282 (22):16532-16543 [Details]
(2006) 'Proteases in helminth-and allergen-induced inflammatory responses'
Donnelly, Sheila and Dalton, John P and Loukas, Alex (2006) 'Proteases in helminth-and allergen-induced inflammatory responses'. Parasites and Allergy, 90 :45-64 [Details]
(2006) 'A. Loukas, $^3$ T. Don, 3 J. McKerrow, 2 DW Halton and PJ Brindley5 1Institute for the Biotechnology of Infectious Diseases, University of Technology Sydney, Westbourne Street, Gore Hill, Sydney, NSW 2065, Australia; 2 Tropical Disease Research Unit and Sandler Center for Basic Research in Parasitic'
Dalton, JP and Caffrey, CR and Sajid, M and Stack, C and Donnelly, S (2006) 'A. Loukas, $^3$ T. Don, 3 J. McKerrow, 2 DW Halton and PJ Brindley5 1Institute for the Biotechnology of Infectious Diseases, University of Technology Sydney, Westbourne Street, Gore Hill, Sydney, NSW 2065, Australia; 2 Tropical Disease Research Unit and Sandler Center for Basic Research in Parasitic'. Parasitic Flatworms: Molecular Biology, Biochemistry, Immunology and Physiology, [Details]
(2006) 'Biochemical characterisation of the recombinant peroxiredoxin (FhePrx) of the liver fluke, Fasciola hepatica'
Sekiya, Mary and Mulcahy, Grace and Irwin, Jane A and Stack, Colin M and Donnelly, Sheila M and Xu, Weibo and Collins, Peter and Dalton, John P (2006) 'Biochemical characterisation of the recombinant peroxiredoxin (FhePrx) of the liver fluke, Fasciola hepatica'. FEBS letters, 580 (21):5016-5022 [Details]
(2005) 'De-glycosylation of Pichia pastoris-produced Schistosoma mansoni cathepsin B eliminates non-specific reactivity with IgG in normal human serum'
Stack, Colin M and Dalton, John P and Cunneen, Mary and Donnelly, Sheila (2005) 'De-glycosylation of Pichia pastoris-produced Schistosoma mansoni cathepsin B eliminates non-specific reactivity with IgG in normal human serum'. Journal of immunological methods, 304 (1-2):151-157 [Details]
(2005) 'Thioredoxin peroxidase secreted by Fasciola hepatica induces the alternative activation of macrophages'
Donnelly, Sheila and O'Neill, Sandra M and Sekiya, Mary and Mulcahy, Grace and Dalton, John P (2005) 'Thioredoxin peroxidase secreted by Fasciola hepatica induces the alternative activation of macrophages'. Infection and immunity, 73 (1):166-173 [Details]
(2005) 'Thioredoxin Peroxidase Secreted by Fasciola hepatica Induces the Alternative Activation of Macrophages'
S Donnelly, SM O'Neill, M Sekiya, G Mulcahy, JP Dalton (2005) 'Thioredoxin Peroxidase Secreted by Fasciola hepatica Induces the Alternative Activation of Macrophages'. Infection And Immunity, [Details]
(2004) 'Leucine aminopeptidase of the human blood flukes, Schistosoma mansoni and Schistosoma japonicum'
McCarthy, Elaine and Stack, Colin and Donnelly, Sheila M and Doyle, Sean and Mann, Victoria H and Brindley, Paul J and Stewart, Michael and Day, Tim A and Maule, Aaron G and Dalton, John P (2004) 'Leucine aminopeptidase of the human blood flukes, Schistosoma mansoni and Schistosoma japonicum'. International journal for parasitology, 34 (6):703-714 [Details]
(2004) 'Helminths at mucosal barriers—interaction with the immune system'
Mulcahy, Grace and O'Neill, Sandra and Donnelly, Sheila and Dalton, JP (2004) 'Helminths at mucosal barriers—interaction with the immune system'. Advanced drug delivery reviews, 56 (6):853-868 [Details]
(2004) 'Cathepsin L1, the major protease involved in liver fluke (Fasciola hepatica) virulence'
Brennan, Gerard and Collins, PR and Dalton, JP and Maule, Aaron and Stack, C and O'Neill, SM and Doyle, S and Ryan, T and Mousley, Angela and Stewart, Michael and others (2004) 'Cathepsin L1, the major protease involved in liver fluke (Fasciola hepatica) virulence'. Journal of Biological Chemistry, 279 (17):17038-17046 [Details]
(2004) 'Cathepsin L1, the major protease involved in liver fluke (Fasciola hepatica) virulence: propeptide cleavage sites and autoactivation of the zymogen secreted from gastrodermal cells'
Collins, Peter R and Stack, Colin M and O'Neill, Sandra M and Doyle, Sean and Ryan, Thecla and Brennan, Gerard P and Mousley, Angela and Stewart, Michael and Maule, Aaron G and Dalton, John P and others (2004) 'Cathepsin L1, the major protease involved in liver fluke (Fasciola hepatica) virulence: propeptide cleavage sites and autoactivation of the zymogen secreted from gastrodermal cells'. Journal of Biological Chemistry, 279 (17):17038-17046 [Details]
(2003) 'Helminth vaccines: from mining genomic information for vaccine targets to systems used for protein expression'
Dalton, John P and Brindley, Paul J and Knox, Dave P and Brady, Ciaran P and Hotez, Peter J and Donnelly, Sheila and O'Neill, Sandra M and Mulcahy, Grace and Loukas, Alex (2003) 'Helminth vaccines: from mining genomic information for vaccine targets to systems used for protein expression'. International journal for parasitology, 33 (5-6):621-640 [Details]
(2003) 'Fasciola hepatica cathepsin L-like proteases: biology, function, and potential in the development of first generation liver fluke vaccines'
Dalton, John P and Neill, Sandra O and Stack, Colin and Collins, Peter and Walshe, Alan and Sekiya, Mary and Doyle, Sean and Mulcahy, Grace and Hoyle, Deborah and Khaznadji, Eric and others (2003) 'Fasciola hepatica cathepsin L-like proteases: biology, function, and potential in the development of first generation liver fluke vaccines'. International journal for parasitology, 33 (11):1173-1181 [Details]
(2001) 'Whole-cell but not acellular pertussis vaccines induce convulsive activity in mice: evidence of a role for toxin-induced interleukin-1$\beta$ in a new murine model for analysis of neuronal side effects of vaccination'
Donnelly, Sheila and Loscher, Christine E and Lynch, Marina A and Mills, Kingston HG (2001) 'Whole-cell but not acellular pertussis vaccines induce convulsive activity in mice: evidence of a role for toxin-induced interleukin-1$\beta$ in a new murine model for analysis of neuronal side effects of vaccination'. Infection and immunity, 69 (7):4217-4223 [Details]
(2000) 'Interleukin-1$\beta$-dependent changes in the hippocampus following parenteral immunization with a whole cell pertussis vaccine'
Loscher, Christine E and Donnelly, Sheila and Mills, Kingston HG and Lynch, Marina A (2000) 'Interleukin-1$\beta$-dependent changes in the hippocampus following parenteral immunization with a whole cell pertussis vaccine'. Journal of Neuroimmunology, 111 (1-2):68-76 [Details]
(2000) 'Induction of inflammatory cytokines in the brain following respiratory infection with Bordetella pertussis'
Loscher, Christine E and Donnelly, Sheila and Lynch, Marina A and Mills, Kingston HG (2000) 'Induction of inflammatory cytokines in the brain following respiratory infection with Bordetella pertussis'. Journal of Neuroimmunology, 102 (2):172-181 [Details]
(1999) 'Glycerol-induced seizure: involvement of IL-1$\beta$ and glutamate'
Donnelly, Sheila and Loscher, Christine and Mills, Kingston HG and Lynch, Marina A (1999) 'Glycerol-induced seizure: involvement of IL-1$\beta$ and glutamate'. Neuroreport, 10 (9):1821-1825 [Details]
(1998) 'Proinflammatory cytokines in the adverse systemic and neurologic effects associated with parenteral injection of a whole cell pertussis vaccine'
Loscher, Christine E and Donnelly, Sheila and McBENNETT, SIOBHAN and Lynch, Marina A and Mills, Kingston HG (1998) 'Proinflammatory cytokines in the adverse systemic and neurologic effects associated with parenteral injection of a whole cell pertussis vaccine'. Annals of the New York Academy of Sciences, 856 (1):274-277 [Details]
(1997) 'Long-term effects of Semliki Forest virus infection in the mouse central nervous system'
Donnelly, SM and Sheahan, BJ and Atkins, GJ (1997) 'Long-term effects of Semliki Forest virus infection in the mouse central nervous system'. Neuropathology and applied neurobiology, 23 (3):235-241 [Details]

Book Chapters

  Year Publication
(2021) 'Immunological interaction between Fasciola and its host'
Donnelly, Sheila and Flynn, Robin and Mulcahy, Grace and O'Neill, Sandra (2021) 'Immunological interaction between Fasciola and its host' In: :278-307 CABI Wallingford UK. [Details]
(2021) 'Applying'omics' technologies to understand Fasciola spp. biology'
Cwiklinski, Krystyna and Verissimo, Carolina de Marco and McVeigh, Paul and Donnelly, Sheila and Dalton, John P (2021) 'Applying'omics' technologies to understand Fasciola spp. biology' In: :338-378 CABI Wallingford UK. [Details]
(2006) 'Proteases in trematode biology'
Dalton, John P and Caffrey, Conor R and Sajid, M and Stack, C and Donnelly, Sheila and Loukas, A and Don, T and McKerrow, James and Halton, DW and Brindley, PJ (2006) 'Proteases in trematode biology' In: :348-368 CABI Wallingford UK. [Details]

Published Reports

  Year Publication
(2022) The immunology of parasite infections: Grand challenges.
Donnelly, Sheila (2022) The immunology of parasite infections: Grand challenges. . [Details]

Honours and Awards

  Year Title Awarding Body
2010 Trailblazer Commercialisation Award Uniquest
2010 i3 Postdoctoral Fellow The i3 Institute, University of Technology, Sydney
2002 New Researcher Award Albert College Fellowship
1994 Visiting Research Award, Unite Rage, Institut Pasteur French Government scholarship for research

Professional Associations

  Association Function From / To
Irish Society of Parasitology Member /

Patents

  Patent Number Title Granted
Crystal structure of PfA-M1 and the PfA-M1 CO4 complex
Immuno-modulating agents and uses therefor

Committees

  Committee Function From / To
University of Technology Sydney, Animal Ethics Committee Chair 01-JAN-20 / 01-DEC-22
University of Technology Sydney, Faculty Teaching and Learning Committee Member /
University of Technology Sydney, Animal Facility Research Group Chair 03-JAN-10 /
University of Technology Sydney, Animal Facility Management Committee Member 01-JAN-10 /

Employment

  Employer Position From / To
University of Galway Senior Lecturer 01-SEP-24 /
University of Galway Research Fellow 01-OCT-23 /
University of Technology Sydney Adjunct Associate Professor 01-JAN-20 /
University of Technology Sydney Associate Professor 01-JAN-17 /
University of Technology Sydney Senior Lecturer 03-FEB-13 /
University of Technology Sydney Research Fellow 10-JAN-10 /
National University of Ireland Maynooth Lecturer - Physiology 01-JAN-09 /
University of Technology Sydney Research Fellow 11-JAN-04 /
Dublin City University Postdoctoral Researcher 01-JAN-01 /
National University of Ireland, Maynooth Postdoctoral Researcher 01-JAN-97 /

Education

  Year Institution Qualification Subject
1997 Trinity College Dublin PhD Viral Immunology
1992 Trinity College Dublin BA(Mod) Microbiology

Teaching Interests

Biotechnology, Immunology, Infectious diseases, Parasitology, Vaccinology, Biotherapeutics.

Recent Postgraduate Students

  Graduation Name Degree Primary Supervisor
2024 Inah C. Camaya PhD Y
2024 Loli Susel Quinteros PhD Y
2024 Giang Le
2022 Aakanksha Dixit PhD
2021 Claire Rennie PhD
2021 Alison Ricafrente PhD Y
2018 Akane Tanaka PhD Y
2015 Maria Lund PhD Y
2015 Raquel Alvarado PhD Y

Internal Collaborators

  Name Description of Collaboration
Prof. John P. Dalton

External Collaborators

  Name Organisation / Institute Country Description of Collaboration
A/Prof Nham Tran University of Technology Sydney, Australia
Dr Nathaniel Snyder Lewis Katz School of Medicine, Temple University, USA
A/Prof Bronwyn O'Brien University of Technology, Sydney
A/Prof Judith Greer University of Queensland, Australia