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Biological and Chemical Sciences

Prof. Paul Murphy

B.Sc.,Ph.D.

 
researcher
 

Biography

Education BSc & PhD, Organic Chemistry, University of Galway (NUI, UCG)  
Experience 1994-96 Chiroscience Postdoctoral Fellow, University of York, UK
1996-2004  Lecturer in Chemistry, University College Dublin
1997, 1998  Visiting Research Scholar, Chemistry Department, University of Pennsylvania, US
2003  Visiting Researcher, Universität Mainz, Germany (Horst Kunz)
2005-6   Senior Lecturer in Chemistry, University College Dublin.
2006-8  Associate Professor, University College Dublin
2007-8  Head of Organic Chemistry, University College Dublin
2007-8  Director of Postgraduate Studies in UCD School of Chemistry and Chemical Biology and Deputy Director of Dublin Chemistry Graduate School
2015     Visiting Research Scholar, Beth Israel Deaconess Medical Centre, Harvard Medical School, Boston, USA
2008-13 and 2014-2017 Head of School of Chemistry, NUI Galway
2008-current   Established Professor of Chemistry NUI Galway 

Paul V Murphy Journal Research Articles (click here for a link to Google Scholar)


Research Interests

Research in the Murphy group is currently financially supported by:

 Science Foundation Ireland and co-funded by the European Regional Development Fund 

 European Commission

Irish Research Council  including an Enterprise Partnership Award supported by Pfizer Pharmaceuticals Ltd

Carbohydrates, glycoscience, synthesis of bioactive compounds

Journal Research Articles (click for a link to Google Scholar) 

The design, synthesis and evaluation of bioactive molecules, including natural products is being undertaken.  A major current interest is in the design and synthesis of glycomimetics.  Current projects are concerned with development of inhibtors of carbohydrate binding proteins such as galectins, macrophage galactose C-type lectin, siglecs and carbohydrate binding proteins involved in infection.  All of these targets are relevant to development of new therapeutics, vaccines or diagnostics for diseases.  In this regard we are interested in both structure based ligand design as well as synthesis of glycoclusters to improve potency and selectivity of inhibitors of carbohydrate binding proteins. 

In the area of glycoscience, and synthesis of smart glycomaterials, we are contributing to the SFI funded Centre for Medical Devices, Curam. (http://www.curamdevices.ie/).

In a contribution to the SFI funded research centre SSPC (www.sspc.ie) and have commenced projects on investigation of continuous flow techniques with a view to carbohydrate drug synthesis applications (e.g. glycomimetics, iminosugars).  

We are also interested in fundamental studies in carbohydrate chemistry and have published research on factors influencing anomer preference as well as reactivity and synthetic studies using anomerisation reactions.

Successes have included stereoselective synthesis of iminosugars, glycolipid synthesis, new peptidomimetics based on carbohydrates/macrocycles.  

We achieved the synthesis of analogues of migrastatin which inhibit tumour cell migration.

We have introduced intramolecular Huisgen azide alkene cycloadditions for heterocycle synthesis and applied it to iminosugar synthesis.  We have extended this to tandem reactions incorporating allylic azide rearrangement.

For a short presentation on Lewis acid promoted anomerisation, which has been an interest of our group, and its application click here: 


For a presentation given in 2020 at the University of Lucknow (India) International Conference on Chemistry, Biology and COVID-19 click below.  This lecture deals with synthesis of iminosugars.

https://youtu.be/dNT7rxhcj1g


Research Projects

  Project Start Date End Date
SSPC Centre for Pharmaceutical Research - Paul Murphy - Moecules 1 - Phase 2 01-JUN-19 31-MAY-25
CARBOHYDRATE-BASED SENSING MATERIALS AS PLATFORMS FOR 3-D PRINTED MICROFLUIDIC PATHOGEN DETECTION DEVICES WITH DIAGNOSTIC AND ENVIRONMENTAL MONITORING APPLICATIONS 01-APR-19 31-MAR-23
CÚRAM PhD Scheme ¿ PM/MOD 01-APR-18 31-MAR-22
DESIGN AND SYNTHESIS OF CARBOHYDRATE BASED THERAPIES FOR FIBROSIS 01-JAN-17 25-OCT-22
IRC Postdoctoral Fellowship 2015 Styliana Mirallai - Benzo[e][1,2,4]triazin-7-ones: Synthesis and Anti-Cancer Activity 01-OCT-16 30-NOV-22
Microactivity Array Supported Lipid Membranes; Highly Versatile Cell Membrane Models in Sickness and in Health 01-JUL-16 30-JUN-20
NPL - Synthesis of Natural Product Like Compounds for Drug 01-SEP-15 31-AUG-17
TARGETING MCL-1 A PROTEIN IMPORTANT IN CANCER PAUL MURPHY 01-OCT-14 30-SEP-22
WELLCOME TRUST SUMMER SCHOLARSHIP PROGRAMME COS PAUL MURPHY 01-JUN-14 31-AUG-15
SPDS LTD INNOVATION VOUCHER PAUL MURPHY 06-MAR-14 06-MAR-15
DIVERGENT SYNTHESIS OF PROPRIETARY MACROCYCLIC SCAFFOLDS AND LIBRARIES FOR SCREENING P MURPHY 01-JAN-14 18-APR-16
IRC POSTGRADUATE AWARD ANTHONY MCDONAGH PAUL MURPHY 01-OCT-13 30-SEP-15
GLYCOSIDE AND GLYCOCOJUNGATE SYNTHESIS THROUGH DEVELOPMENT AND APPLICATION OF CHELATION INDUCED ANOMERIZATION PAUL MURPHY 01-APR-13 31-MAR-19
NEW MACROCYCLIC PEPTIDOMIMETICS WITH POTENTIAL IN CANCER THERAPY PAUL MURPHY 01-JAN-13 30-JUN-15
IRC EMBARK SINCLAIR SWEENEY PAUL MURPHY 01-OCT-12 30-SEP-15
SFI FREE SPACE OPTICAL COMMUNICATION 11 W 1 I2066 CHRIS DAINTY 21-MAY-12 02-NOV-13
JATROPHONE ANALOGUES EU FP 7 MC IEF PIEF GA 2011 299042 MDR MODULATOR PAUL MURPHY 01-APR-12 31-MAR-14
IRCSET POST DOC AWARD PAUL MURPHY 01-FEB-12 31-JAN-13
SFI TIDA AWARD PAUL MURPHY 11/TIDA/B2047 01-JAN-12 31-OCT-14
DEVELOPMENT OF NOVEL INHIBITORS OF OCULAR NEOVASCULARISATION SFI TIDA PAUL MURPHY 01-JAN-12 30-SEP-14
ADULT EDUCATION CHEMISTRY PAUL MURPHY 01-AUG-11 01-AUG-21
DEVELOPMENT OF A PRODUCT FOR BEES IV 2011 1163 PAUL MURPHY 05-APR-11 30-NOV-11
Chris Dainty RSF STRAT INI Improving the outcome of cataract surgery 01-APR-11 31-DEC-13
IRCSET SYNTHESIS OF BIOACTIVE MOLCULES BASED ON CARBOHYDRATES PAUL MURPHY 01-OCT-10 31-DEC-13
CONSULTANCY GENERAL VATABLE ACCOUNT PAUL MURPHY 01-MAY-10 30-DEC-15
COST WORKSHOP CM0602 02520 PAUL MURPHY 01-MAR-10 31-DEC-25
SFI 07 IN1 1906 TIDA 09 CHRIS DAINTY 30-DEC-09 28-APR-12
IRCSET POSTGRAD PAUL MURPHY MICHELLE MCKINNEY 01-OCT-09 31-JUL-13
IRCSET POSTGRAD PAUL MURPHY LORNA MOYNIHAN 01-OCT-09 30-SEP-13
ALPHA HELICAL PEPTS RFP/06/CHO032 - PAUL MURPHY 01-JAN-09 28-FEB-10
INVESTIGATION IMMUNE RESPONSE 06/RP/CHEF522 STTF08 - P MURPHY 01-DEC-08 30-NOV-09
FP7 MC GLYCOPEPTIDES MURPHY DILIP 06-NOV-08 01-NOV-12
BURNQUEST OVERHEADS COMBUSTION CHEM J SIMMIE 01-AUG-08 31-DEC-12
Towards Novel Therapeutics for Angiogenesis 01-APR-08 26-APR-15
2053028 INFECTION GLYCOMICS KARLSON INTEG A SAVAGE 21-JAN-08 20-JAN-12
HOS USING MASS SPECTROMETRY FOR IDENTIFYING COMPONENTS 01-SEP-07 31-DEC-13
J SIMMIE BURNQUEST FP6 517248 LABOUR OVHD OTHER 01-JAN-05 17-NOV-09
SIMMIE BURNQUEST FP6 517248 TRAV AND CONS 01-JAN-05 31-AUG-09
EU ENK5 CT2002 50516 CLEANBURN SIMMIE 01-DEC-02 31-JUL-09
IRCSET EAMON MOLONEY PHD PROF RN BUTLER 01-OCT-02 11-FEB-09
EU MAST B LIQUID ENK5 2002 00668 01-OCT-02 30-SEP-08
IRCSET AOIFE FAHY PHD PROF BUTLER 30-SEP-02 11-FEB-09
EPA S AND MOEE 2001 PHD 29 44 HOS 01-OCT-01 23-JUL-18
940 EU CONC ACTION TOSTG SPILLANE 01-JAN-99 30-SEP-09
930 ENT IR SC 97 517 HEANEY 01-OCT-97 11-MAR-08
HIGHFIELD NMR PROF R BUTLER 01-JAN-94 31-DEC-23
CHEMORAN R BUTLER 01-JAN-94 31-DEC-13
CORROSION RESEARCH A C CARROLL CHEM 01-JAN-94 31-DEC-13
IRC ENTERPRISE PARTNERSHIP SCHEME (POSTGRADUATE) 2019 - Jack Bennett - New Synthesis For Glycomimetic Research: Comparing Traditional Batch Chemistry With Continuous Flow 01-MAR-19 28-FEB-23
IRC POSTGRADUATE SCHOLARSHIP 2018 AILBHE RYAN - DEVELOPMENT OF INFLUENZA VIRUS HEMAGGLUTININ INHIBITING COMPOUNDS - EMPLOYMENT OF THE STRUCURE BASED DESIGN APPROACH TO DEVELOP NOVEL CONSTRAINED GLYCOMIMETRICS 01-OCT-18 30-SEP-20
ENHANCING THE SCIENTIST¿S TOOLBOX USING SYNTHETIC CARBOHYDRATE CHEMISTRY 01-MAR-18 28-FEB-23
CONTINUOUS FLOW CHEMISTRY EQUIPMENT FOR SUGAR RESEARCH 01-DEC-17 31-MAY-21
CÚRAM ¿ MedTrain Co-fund ¿ Paul Murphy 01-AUG-17 31-DEC-20
IRC Postgrad 2016 ADELE GABBA - Design and synthesis inhibitors for macrophage galactose C-type lectin; chemical tools for immunological research. 01-OCT-16 30-SEP-20

Peer Reviewed Journals

  Year Publication
(2021) 'Immunomodulatory properties of characellide A on human peripheral blood mononuclear cells'
Simone Marcella, Sam Afoullouss, Olivier P Thomas, A Louise Allcock, Paul V Murphy, Stefania Loffredo (2021) 'Immunomodulatory properties of characellide A on human peripheral blood mononuclear cells'. Inflammopharmacology, 29 :1201-1210 [DOI] [Details]
(2021) 'Probing Sulfatide-Tissue Lectin Recognition with Functionalized Glycodendrimersomes'
Paul V. Murphy, Antonio Romero, Qi Xiao, Anna-Kristin Ludwig, Srinivas Jogula, Nadezhda V. Shilova, Tanuja Singh, Adele Gabba, Bilal Javed, Dapeng Zhang, Francisco J. Medrano, Herbert Kaltner, Jürgen Kopitz, Nicolai V. Bovin, Albert M. Wu, Michael L. Klein, Virgil Percec, Hans-Joachim Gabius (2021) 'Probing Sulfatide-Tissue Lectin Recognition with Functionalized Glycodendrimersomes'. Iscience, [DOI] [ARAN Link] [Details]
(2020) 'Influence of protein (human galectin-3) design on aspects of lectin activity'
Caballero, GG;Beckwith, D;Shilova, NV;Gabba, A;Kutzner, TJ;Ludwig, AK;Manning, JC;Kaltner, H;Sinowatz, F;Cudic, M;Bovin, NV;Murphy, PV;Gabius, HJ (2020) 'Influence of protein (human galectin-3) design on aspects of lectin activity'. Histochemistry and cell biology, [DOI] [ARAN Link] [Details]
(2020) 'Development of Mcl-1 Inhibitors for Cancer Therapy'
Arvind Negi, Paul V Murphy (2020) 'Development of Mcl-1 Inhibitors for Cancer Therapy'. European Journal Of Medicinal Chemistry, [DOI] [ARAN Link] [Details]
(2020) '2,3,6-Tri-O-benzoyl-4-O-(tert-butyldimethylsilyl)-β-D-galactopyranoside'
Jack Bennett, Paul V. Murphy (2020) '2,3,6-Tri-O-benzoyl-4-O-(tert-butyldimethylsilyl)-β-D-galactopyranoside'. Molbank, 2017 [DOI] [ARAN Link] [Details]
(2020) 'Building blocks from monosaccharides for synthesis of scaffolds, including macrocycles. Application of allylic azide rearrangement, azide-alkyne cycloaddition and ring closing metathesis'
Karen Fox, Rekha Chadda, Francisco Cardona, Stephen Barron, Patrick McArdle, Paul V. Murphy (2020) 'Building blocks from monosaccharides for synthesis of scaffolds, including macrocycles. Application of allylic azide rearrangement, azide-alkyne cycloaddition and ring closing metathesis'. Tetrahedron, [DOI] [ARAN Link] [Details]
(2020) 'Microcavity array supported lipid bilayer models of ganglioside - influenza hemagglutinin(1)binding'
Berselli, GB,Sarangi, NK,Gimenez, AV,Murphy, PV,Keyes, TE (2020) 'Microcavity array supported lipid bilayer models of ganglioside - influenza hemagglutinin(1)binding'. Chemical Communications, 56 :11251-11254 [DOI] [ARAN Link] [Details]
(2019) 'Microcavity supported lipid membranes: versatile platforms for building asymmetric lipid bilayers and for protein recognition'
Guilherme Berselli, Sivaramakrishnan Ramadurai, Nirod Sarangi, Paul V. Murphy, Tia Keyes (2019) 'Microcavity supported lipid membranes: versatile platforms for building asymmetric lipid bilayers and for protein recognition'. ACS Applied Bio Materials, [DOI] [Details]
(2019) 'How altering the modular architecture affects aspects of lectin activity: case study on human galectin-1'
Kutzner TJ;Gabba A;FitzGerald FG;Shilova NV;García Caballero G;Ludwig AK;Manning JC;Knospe C;Kaltner H;Sinowatz F;Murphy PV;Cudic M;Bovin NV;Gabius HJ; (2019) 'How altering the modular architecture affects aspects of lectin activity: case study on human galectin-1'. Glycobiology, 29 (8) [DOI] [Details]
(2019) 'N-Alkyl-1,5-dideoxy-1,5-imino-l-fucitols as fucosidase inhibitors: Synthesis, molecular modelling and activity against cancer cell lines'
Zhou J;Negi A;Mirallai SI;Warta R;Herold-Mende C;Carty MP;Ye XS;Murphy PV; (2019) 'N-Alkyl-1,5-dideoxy-1,5-imino-l-fucitols as fucosidase inhibitors: Synthesis, molecular modelling and activity against cancer cell lines'. Bioorganic Chemistry, 84 [DOI] [ARAN Link] [Details]
(2019) 'Ligand design for somatostatin receptor isoforms 4 and 5'
Arvind Negi and Jian Zhou and Sinclair Sweeney and Paul V. Murphy (2019) 'Ligand design for somatostatin receptor isoforms 4 and 5'. European Journal of Medicinal Chemistry, 163 :148-159 [DOI] [ARAN Link] [Details]
(2019) 'Lewis acid promoted anomerisation of alkyl O- and S-xylo-, arabino- and fucopyranosides'
Doyle LM;Meany FB;Murphy PV; (2019) 'Lewis acid promoted anomerisation of alkyl O- and S-xylo-, arabino- and fucopyranosides'. Carbohydrate Research, 471 [DOI] [ARAN Link] [Details]
(2018) 'Anomer Preferences for Glucuronic and Galacturonic Acid and Derivatives and Influence of Electron-Withdrawing Substituents'
Kerins, L,Byrne, S,Gabba, A,Murphy, PV (2018) 'Anomer Preferences for Glucuronic and Galacturonic Acid and Derivatives and Influence of Electron-Withdrawing Substituents'. Journal Of Organic Chemistry, 83 :7714-7729 [DOI] [Details]
(2018) 'Influence of acyl groups on glucopyranoside reactivity in Lewis acid promoted anomerisation'
Mark P. Farrell and Lisa M. Doyle and Paul V. Murphy (2018) 'Influence of acyl groups on glucopyranoside reactivity in Lewis acid promoted anomerisation'. Tetrahedron Letters, 59 (28):2726-2731 [DOI] [ARAN Link] [Details]
(2018) 'Revealing biomedically relevant cell and lectin type-dependent structure–activity profiles for glycoclusters by using tissue sections as an assay platform'
Kaltner, Herbert and Manning, Joachim C. and García Caballero, Gabriel and Di Salvo, Claudia and Gabba, Adele and Romero-Hernández, Laura L. and Knospe, Clemens and Wu, Dan and Daly, Harrison C. and O'Shea, Donal F. and Gabius, Hans-Joachim and Murphy, Paul V. (2018) 'Revealing biomedically relevant cell and lectin type-dependent structure–activity profiles for glycoclusters by using tissue sections as an assay platform'. RSC Adv, 8 :28716-28735 [DOI] [ARAN Link] [Details]
(2017) 'Stereoselective epimerizations of glycosyl thiols'
Lisa M. Doyle, Shane O’Sullivan, Claudia Di Salvo, Michelle McKinney, Patrick McArdle and Paul V. Murphy (2017) 'Stereoselective epimerizations of glycosyl thiols'. Organic Letters, 19 :5802-5805 [DOI] [ARAN Link] [Details]
(2017) 'Synthesis and Biological Evaluation of Migrastatin Macrotriazoles'
Gabba, A,Robakiewicz, S,Taciak, B,Ulewicz, K,Broggini, G,Rastelli, G,Krol, M,Murphy, PV,Passarella, D (2017) 'Synthesis and Biological Evaluation of Migrastatin Macrotriazoles'. European Journal Of Organic Chemistry, 2017 :60-69 [DOI] [Details]
(2017) 'Teaming up synthetic chemistry and histochemistry for activity screening in galectin-directed inhibitor design'
Roy, R,Cao, YH,Kaltner, H,Kottari, N,Shiao, TC,Belkhadem, K,Andre, S,Manning, JC,Murphy, PV,Gabius, HJ (2017) 'Teaming up synthetic chemistry and histochemistry for activity screening in galectin-directed inhibitor design'. Histochem Cell Biol, 147 :285-301 [DOI] [Details]
(2017) 'Isolation and synthesis of pygmanilines, phenylurea derivatives from the Northeastern Atlantic lichen Lichina pygmaea'
Mahajan, N,Chadda, R,Calabro, K,Solanki, H,O'Connell, E,Murphy, PV,Thomas, OP (2017) 'Isolation and synthesis of pygmanilines, phenylurea derivatives from the Northeastern Atlantic lichen Lichina pygmaea'. Tetrahedron Letters, 58 :1237-1239 [DOI] [Details]
(2017) 'Allylic azide rearrangement in tandem with intramolecular Huisgen cycloaddition for iminosugar and glycomimetic synthesis. Functionalized piperidine, pyrrolidine and pyrrolotriazoles from D-mannose'
Rekha Chadda, Patrick McArdle and Paul V. Murphy (2017) 'Allylic azide rearrangement in tandem with intramolecular Huisgen cycloaddition for iminosugar and glycomimetic synthesis. Functionalized piperidine, pyrrolidine and pyrrolotriazoles from D-mannose'. Synthesis, 49 (10):2138-2152 [DOI] [ARAN Link] [Details]
(2017) '2,3,6-Tri-O-benzoyl-4-O-(tert-butyldimethylsilyl)-β-D-galactopyranoside'
Jack Bennett, Amélie Roux, Paul V. Murphy (2017) '2,3,6-Tri-O-benzoyl-4-O-(tert-butyldimethylsilyl)-β-D-galactopyranoside'. 2017 [DOI] [ARAN Link] [Details]
(2017) 'Carbohydrate Chemistry Proven Synthetic Methods Volume 4 Introduction'
Vogel, C;Murphy, PV (2017) 'Carbohydrate Chemistry Proven Synthetic Methods Volume 4 Introduction'. Carbohydrate Chemistry: Proven Synthetic Methods, Vol 2, 4 [Details]
(2017) 'Synthesis of Benzoylated beta-D-Glucosamine Derivatives'
Di Salvo, C;Fox, KA;Murphy, PV;Langhanki, J (2017) 'Synthesis of Benzoylated beta-D-Glucosamine Derivatives'. Carbohydrate Chemistry: Proven Synthetic Methods, Vol 2, 4 :99-107 [ARAN Link] [Details]
(2016) 'Multivalent carbohydrate-lectin interactions: the way synthetic chemistry enables insights into nanometric recognition'
R. Roy, P. V. Murphy, and H.-J. Gabius (2016) 'Multivalent carbohydrate-lectin interactions: the way synthetic chemistry enables insights into nanometric recognition'. Molecules (Basel, Switzerland), 21 [ARAN Link] [Details]
(2016) 'Coiled coil type neoglycoproteins presenting three lactose residues'
Sweeney, SM,Bullen, GA,Gillis, RB,Adams, GG,Rowe, AJ,Harding, SE,Tucker, JHR,Peacock, AFA,Murphy, PV (2016) 'Coiled coil type neoglycoproteins presenting three lactose residues'. Tetrahedron Letters, 57 :1414-1417 [DOI] [ARAN Link] [Details]
(2016) 'Lewis Acid Induced Anomerization of Se-Glycosides. Application to Synthesis of alpha-Se-GalCer'
McDonagh, AW,Mahon, MF,Murphy, PV (2016) 'Lewis Acid Induced Anomerization of Se-Glycosides. Application to Synthesis of alpha-Se-GalCer'. Organic Letters, 18 :552-555 [DOI] [ARAN Link] [Details]
(2016) 'Synthesis of an Orthogonally Protected Polyhydroxylated Cyclopentene from l-Sorbose'
Lo Re, D,Jones, L,Giralt, E,Murphy, P (2016) 'Synthesis of an Orthogonally Protected Polyhydroxylated Cyclopentene from l-Sorbose'. Chemistry-An Asian Journal, 11 :2035-2040 [DOI] [ARAN Link] [Details]
(2015) 'Bi- to tetravalent glycoclusters presenting GlcNAc/GalNAc as inhibitors: from plant agglutinins to human macrophage galactose-type lectin (CD301) and galectins'
Andre, S,O'Sullivan, S,Koller, C,Murphy, PV,Gabius, HJ (2015) 'Bi- to tetravalent glycoclusters presenting GlcNAc/GalNAc as inhibitors: from plant agglutinins to human macrophage galactose-type lectin (CD301) and galectins'. Organic & Biomolecular Chemistry, 13 :4190-4203 [DOI] [ARAN Link] [Details]
(2015) 'Decorated Macrocycles via Ring-Closing Double-Reductive Amination. Identification of an Apoptosis Inducer of Leukemic Cells That at Least Partially Antagonizes a 5-HT2 Receptor'
Zhou, J,Reidy, M,O'Reilly, C,Jarikote, DV,Negi, A,Samali, A,Szegezdi, E,Murphy, PV (2015) 'Decorated Macrocycles via Ring-Closing Double-Reductive Amination. Identification of an Apoptosis Inducer of Leukemic Cells That at Least Partially Antagonizes a 5-HT2 Receptor'. Organic Letters, 17 :1672-1675 [DOI] [ARAN Link] [Details]
(2015) 'Engineering a Therapeutic Lectin by Uncoupling Mitogenicity from Antiviral Activity'
Swanson MD, Boudreaux DM;Salmon L;Chugh J;Winter HC;Meagher JL;Andr¿¿ S;Murphy PV;Oscarson S;Roy R;King S;Kaplan MH;Goldstein IJ;Tarbet EB;Hurst BL;Smee DF;de la Fuente C;Hoffmann HH;Xue Y;Rice CM;Schols D;Garcia JV;Stuckey JA;Gabius HJ;Al-Hashimi HM;Markovitz DM (2015) 'Engineering a Therapeutic Lectin by Uncoupling Mitogenicity from Antiviral Activity'. Cell, 163 (3):746-758 [DOI] [ARAN Link] [Details]
(2015) 'Synthesis of Migrastatin Analogues as Inhibitors of Tumour Cell Migration: Exploring Structural Change in and on the Macrocyclic Ring'
Lo Re D, Zhou Y;Mucha J;Jones LF;Leahy L;Santocanale C;Krol M;Murphy PV (2015) 'Synthesis of Migrastatin Analogues as Inhibitors of Tumour Cell Migration: Exploring Structural Change in and on the Macrocyclic Ring'. Chemistry (Weinheim an der Bergstrasse, Germany), [DOI] [ARAN Link] [Details]
(2015) 'Merging carbohydrate chemistry with lectin histochemistry to study inhibition of lectin binding by glycoclusters in the natural tissue context'
Andr¿¿ S, Kaltner H;Kayser K;Murphy PV;Gabius HJ (2015) 'Merging carbohydrate chemistry with lectin histochemistry to study inhibition of lectin binding by glycoclusters in the natural tissue context'. Histochemistry and cell biology, [DOI] [Details]
(2015) 'Allylic Azide Rearrangement in Tandem with Huisgen Cycloaddition for Stereoselective Annulation: Synthesis of C-Glycosyl Iminosugars'
Moynihan, L,Chadda, R,McArdle, P,Murphy, PV (2015) 'Allylic Azide Rearrangement in Tandem with Huisgen Cycloaddition for Stereoselective Annulation: Synthesis of C-Glycosyl Iminosugars'. Organic Letters, 17 :6226-6229 [DOI] [ARAN Link] [Details]
(2015) 'Synthesis of Migrastatin Analogues as Inhibitors of Tumour Cell Migration: Exploring Structural Change in and on the Macrocyclic Ring'
Lo Re, D,Zhou, Y,Mucha, J,Jones, LF,Leahy, L,Santocanale, C,Krol, M,Murphy, PV (2015) 'Synthesis of Migrastatin Analogues as Inhibitors of Tumour Cell Migration: Exploring Structural Change in and on the Macrocyclic Ring'. Chemistry-A European Journal, 21 :18109-18121 [DOI] [ARAN Link] [Details]
(2015) 'Glycoclusters as lectin inhibitors: comparative analysis on two plant agglutinins with different folding as a step towards rules for selectivity'
Andre, S,O'Sullivan, S,Gabius, HJ,Murphy, PV (2015) 'Glycoclusters as lectin inhibitors: comparative analysis on two plant agglutinins with different folding as a step towards rules for selectivity'. Tetrahedron, 71 :6867-6880 [DOI] [ARAN Link] [Details]
(2015) 'Lectins: Getting Familiar with Translators of the Sugar Code'
Andre, S,Kaltner, H,Manning, JC,Murphy, PV,Gabius, HJ (2015) 'Lectins: Getting Familiar with Translators of the Sugar Code'. Molecules (Basel, Switzerland), 20 :1788-1823 [DOI] [ARAN Link] [Details]
(2014) 'Combining glycocluster synthesis with protein engineering: an approach to probe into the significance of linker length in a tandem-repeat-type lectin (galectin-4)'
Andre, S,Wang, GN,Gabius, HJ,Murphy, PV (2014) 'Combining glycocluster synthesis with protein engineering: an approach to probe into the significance of linker length in a tandem-repeat-type lectin (galectin-4)'. Carbohydrate Research, 389 :25-38 [DOI] [ARAN Link] [Details]
(2014) 'Synthesis of iminosugar derivatives presenting naphthyl and alkyl amine interacting groups and binding to somatostatin receptors'
Barron, S,Murphy, PV (2014) 'Synthesis of iminosugar derivatives presenting naphthyl and alkyl amine interacting groups and binding to somatostatin receptors'. Medchemcomm, 5 :1150-1158 [DOI] [ARAN Link] [Details]
(2014) 'Synthesis of alpha-galactosyl ceramide analogues with an a-triazole at the anomeric carbon'
McDonagh, AW,Murphy, PV (2014) 'Synthesis of alpha-galactosyl ceramide analogues with an a-triazole at the anomeric carbon'. Tetrahedron, 70 :3191-3196 [DOI] [ARAN Link] [Details]
(2014) 'Ultrasonic Energy Promoted Allylation to Generate 1-C-(2,3,4,6-Tetra-O-Benzyl-alpha-D-Glucopyranosyl)prop-2-ene'
Farrell, M,O'Reilly, C,Jarikote, DV,Murphy, PV,Rahkila, J,VanDerMarel, G,Codee, J (2014) 'Ultrasonic Energy Promoted Allylation to Generate 1-C-(2,3,4,6-Tetra-O-Benzyl-alpha-D-Glucopyranosyl)prop-2-ene'. Carbohydrate Chemistry: Proven Synthetic Methods, Vol 2, 2 :33-37 [Details]
(2014) 'Synthesis of Migrastatin and its Macroketone Analogue and In Vivo FRAP Analysis of the Macroketone on E-Cadherin Dynamics'
Lo Re, D,Zhou, Y,Nobis, M,Anderson, KI,Murphy, PV (2014) 'Synthesis of Migrastatin and its Macroketone Analogue and In Vivo FRAP Analysis of the Macroketone on E-Cadherin Dynamics'. Chembiochem, 15 :1459-1464 [DOI] [ARAN Link] [Details]
(2013) 'Lack of activation of UCP1 in isolated brown adipose tissue mitochondria by glucose-O-ω-modified saturated fatty acids of various chain lengths'
Breen EP, Pilgrim W, Clarke KJ, Yssel C, Farrell M, Zhou J, Murphy PV, Porter RK (2013) 'Lack of activation of UCP1 in isolated brown adipose tissue mitochondria by glucose-O-ω-modified saturated fatty acids of various chain lengths'. Chemistry & Biology, 6 (3):121-133 [DOI] [Details]
(2013) 'Regiospecific Anomerisation of Acylated Glycosyl Azides and Benzoylated Disaccharides by Using TiCl4'
Farrell M, Zhou J, Murphy PV (2013) 'Regiospecific Anomerisation of Acylated Glycosyl Azides and Benzoylated Disaccharides by Using TiCl4'. Chemistry (Weinheim an der Bergstrasse, Germany), 19 (44):14836-14851 [DOI] [ARAN Link] [Details]
(2013) 'Migrastatin analogues inhibit canine mammary cancer cell migration and invasion'
Majchrzak K, Lo Re D, Gajewska M, Bulkowska M, Homa A, Pawłowski K, Motyl T, Murphy PV, Król M (2013) 'Migrastatin analogues inhibit canine mammary cancer cell migration and invasion'. Plos One, 8 (10) [DOI] [ARAN Link] [Details]
(2013) 'Synthesis of α-O- and α-S-glycosphingolipids related to Sphingomonous cell wall antigens using anomerisation'
Pilgrim W, O'Reilly C, Murphy PV (2013) 'Synthesis of α-O- and α-S-glycosphingolipids related to Sphingomonous cell wall antigens using anomerisation'. Molecules (Basel, Switzerland), 18 (9):11198-11218 [DOI] [ARAN Link] [Details]
(2013) 'Cdc7-dependent and -independent phosphorylation of Claspin in the induction of the DNA replication checkpoint'
Rainey MD, Harhen B, Wang GN, Murphy PV, Santocanale C (2013) 'Cdc7-dependent and -independent phosphorylation of Claspin in the induction of the DNA replication checkpoint'. Cell Cycle, 12 (10) [Details]
(2013) 'The third dimension of reading the sugar code by lectins: design of glycoclusters with cyclic scaffolds as tools with the aim to define correlations between spatial presentation and activity'
Murphy PV, André S, Gabius HJ (2013) 'The third dimension of reading the sugar code by lectins: design of glycoclusters with cyclic scaffolds as tools with the aim to define correlations between spatial presentation and activity'. Molecules (Basel, Switzerland), 18 (4):4026-4053 [DOI] [ARAN Link] [Details]
(2013) 'Multivalent glycoconjugates as anti-pathogenic agents'
Bernardi A, Jiménez-Barbero J, Casnati A, De Castro C, Darbre T, Fieschi F, Finne J, Funken H, Jaeger KE, Lahmann M, Lindhorst TK, Marradi M, Messner P, Molinaro A, Murphy PV, Nativi C, Oscarson S, Penadés S, Peri F, Pieters RJ, Renaudet O, Reymond JL, Richichi B, Rojo J, Sansone F, Schäffer C, Turnbull WB, Velasco-Torrijos T, Vidal S, Vincent S, Wennekes T, Zuilhof H, Imberty A (2013) 'Multivalent glycoconjugates as anti-pathogenic agents'. Chemical Society reviews, 42 (11):4709-4727 [DOI] [Details]
(2012) 'Bi- to tetravalent glycoclusters: synthesis, structure-activity profiles as lectin inhibitors and impact of combining both valency and headgroup tailoring on selectivity'
Wang GN, André S, Gabius HJ, Murphy PV (2012) 'Bi- to tetravalent glycoclusters: synthesis, structure-activity profiles as lectin inhibitors and impact of combining both valency and headgroup tailoring on selectivity'. Organic & Biomolecular Chemistry, 10 (34):6893-6907 [DOI] [ARAN Link] [Details]
(2012) 'Synthesis of bivalent glycoclusters containing GlcNAc as hexasaccharide mimetics. Bactericidal activity against Helicobacter pylori'
Yan D, Naughton J, Clyne M, Murphy PV (2012) 'Synthesis of bivalent glycoclusters containing GlcNAc as hexasaccharide mimetics. Bactericidal activity against Helicobacter pylori'. Carbohydrate research, 360 :1-7 [DOI] [ARAN Link] [Details]
(2012) 'Synthesis of bivalent lactosides and their activity as sensors for differences between lectins in inter- and intrafamily comparisons'
Andre, S,Jarikote, DV,Yan, DD,Vincenz, L,Wang, GN,Kaltner, H,Murphy, PV,Gabius, HJ (2012) 'Synthesis of bivalent lactosides and their activity as sensors for differences between lectins in inter- and intrafamily comparisons'. Bioorganic & Medicinal Chemistry Letters, 22 :313-318 [DOI] [ARAN Link] [Details]
(2012) 'Inhibition of Burkholderia multivorans Adhesion to Lung Epithelial Cells by Bivalent Lactosides'
Wright, C,Leyden, R,Murphy, PV,Callaghan, M,Velasco-Torrijos, T,McClean, S (2012) 'Inhibition of Burkholderia multivorans Adhesion to Lung Epithelial Cells by Bivalent Lactosides'. Molecules (Basel, Switzerland), 17 :10065-10071 [DOI] [ARAN Link] [Details]
(2011) 'Synthesis of α-S-glycosphingolipids based on uronic acids'
O'Reilly C, Murphy PV (2011) 'Synthesis of α-S-glycosphingolipids based on uronic acids'. Organic Letters, 13 (19):5168-5171 [DOI] [Details]
(2011) 'Synthesis of a Benzomacrolactone-Based Somatostatin Mimetic'
Zhou, J,Matos, MC,Murphy, PV (2011) 'Synthesis of a Benzomacrolactone-Based Somatostatin Mimetic'. Organic Letters, 13 :5716-5719 [DOI] [Details]
(2011) 'Biological study of a somatostatin mimetic based on the 1-deoxynojrimycin scaffold'
Zhao, YX,Liu, M,Chagnault, V,Wang, JY,Zhang, XM,Murphy, PV (2011) 'Biological study of a somatostatin mimetic based on the 1-deoxynojrimycin scaffold'. Bioorganic & Medicinal Chemistry Letters, 21 :824-828 [DOI] [Details]
(2010) 'SnCl4- and TiCl4-Catalyzed Anomerization of Acylated O- and S-Glycosides: Analysis of Factors That Lead to Higher alpha:beta Anomer Ratios and Reaction Rates'
Pilgrim, W,Murphy, PV (2010) 'SnCl4- and TiCl4-Catalyzed Anomerization of Acylated O- and S-Glycosides: Analysis of Factors That Lead to Higher alpha:beta Anomer Ratios and Reaction Rates'. Journal Of Organic Chemistry, 75 :6747-6755 [DOI] [ARAN Link] [Details]
(2010) 'Synthesis of congeners of migrastatin and dorrigocin A from D-xylose'
Zhou, Y,Murphy, PV (2010) 'Synthesis of congeners of migrastatin and dorrigocin A from D-xylose'. Tetrahedron Letters, 51 :5262-5264 [DOI] [Details]
(2010) 'Biological study of the Angiogenesis Inhibitor N-(8-(3-ethynylphenoxy)octyl-1-deoxynojirimycin'
Zhao, YX,Zhou, Y,Boyle, KMO,Murphy, PV (2010) 'Biological study of the Angiogenesis Inhibitor N-(8-(3-ethynylphenoxy)octyl-1-deoxynojirimycin'. Chemical Biology & Drug Design, 75 :570-577 [DOI] [Details]
(2010) 'Access to Resorcylic Acid Lactones via Phosphonate Based Intramolecular Olefination'
Napolitano, C,McArdle, P,Murphy, PV (2010) 'Access to Resorcylic Acid Lactones via Phosphonate Based Intramolecular Olefination'. Journal Of Organic Chemistry, 75 :7404-7407 [DOI] [Details]
(2010) 'N-(8-(3-Ethynylphenoxy)octyl-1-deoxynojirimycin suppresses growth and migration of human lung cancer cells'
Zhao, Y,Liu, W,Zhou, Y,Zhang, X,Murphy, PV (2010) 'N-(8-(3-Ethynylphenoxy)octyl-1-deoxynojirimycin suppresses growth and migration of human lung cancer cells'. Bioorganic & Medicinal Chemistry Letters, 20 :7540-7543 [DOI] [Details]
(2010) 'Ultrasound assisted synthesis of C-glycosides'
Jarikote,D.V., O'Reilly,C., Murphy,P.V. (2010) 'Ultrasound assisted synthesis of C-glycosides'. Tetrahedron Letters, 51 :6776-6778 [Details]
(2010) 'Metathesis and macrocycles with embedded carbohydrates'
Jarikote,D.V, Murphy,P.V. (2010) 'Metathesis and macrocycles with embedded carbohydrates'. European Journal of Organic Chemistry Microreview), :4959-4970 [Details]
(2010) 'Synthesis of congeners of the migrastatin and dorrigocin: A core structures from D-xylose'
Zhou,Y., Murphy,P.V. (2010) 'Synthesis of congeners of the migrastatin and dorrigocin: A core structures from D-xylose'. Tetrahedron Letters, 51 :5262-5264 [Details]
(2009) 'Synthesis of bivalent lactosides based on terephthalamide, N,N’ diglucosylterephthalamide and glycophane scaffolds and assessment of their inhibitory capacity on medically relevant lectins'
Leyden,R., Velasco-Torrijos,T., ré,S., Gouin,S.G., Gabius,H.J., Murphy,P.V. (2009) 'Synthesis of bivalent lactosides based on terephthalamide, N,N’ diglucosylterephthalamide and glycophane scaffolds and assessment of their inhibitory capacity on medically relevant lectins'. Journal of Organic Chemistry, 74 :9010-9026 [DOI] [Details]
(2009) 'Synthesis of a Novel Polyhydroxylated Salicylic Acid Lactone Framework'
Rountree, JSS,Murphy, PV (2009) 'Synthesis of a Novel Polyhydroxylated Salicylic Acid Lactone Framework'. Organic Letters, 11 :871-874 [DOI] [Details]
(2009) 'alpha-Glycosphingolipids via Chelation-Induced Anomerization of O- and S-Glucuronic and Galacturonic Acid Derivatives'
Pilgrim, W,Murphy, PV (2009) 'alpha-Glycosphingolipids via Chelation-Induced Anomerization of O- and S-Glucuronic and Galacturonic Acid Derivatives'. Organic Letters, 11 :939-942 [DOI] [Details]
(2009) 'Glycotriazolophane Synthesis via Click Chemistry'
Leyden, R,Murphy, PV (2009) 'Glycotriazolophane Synthesis via Click Chemistry'. Synlett, :1949-1950 [DOI] [Details]
(2009) 'Phenylenediamine-based bivalent glycocyclophanes: synthesis and analysis of the influence of scaffold rigidity and ligand spacing on lectin binding in cell systems with different glycomic profiles'
Andre, S,Velasco-Torrijos, T,Leyden, R,Gouin, S,Tosin, M,Murphy, PV,Gabius, HJ (2009) 'Phenylenediamine-based bivalent glycocyclophanes: synthesis and analysis of the influence of scaffold rigidity and ligand spacing on lectin binding in cell systems with different glycomic profiles'. Organic & Biomolecular Chemistry, 7 :4715-4725 [DOI] [Details]
(2009) 'Synthesis of a constrained polyfunctional bicyclic iminocyclitol scaffold from L-sorbose via a tandem sequence including stereoselective intramolecular Huisgen cycloaddition'
O'Reilly, C,O'Brien, C,Murphy, PV (2009) 'Synthesis of a constrained polyfunctional bicyclic iminocyclitol scaffold from L-sorbose via a tandem sequence including stereoselective intramolecular Huisgen cycloaddition'. Tetrahedron Letters, 50 :4427-4429 [DOI] [Details]
(2008) 'Monosaccharide scaffolds for the synthesis of novel compounds'
Murphy,P.V., Velasco-Torrijos,T. (2008) 'Monosaccharide scaffolds for the synthesis of novel compounds'. Glycoscience-Chemistry and Chemical Biology, :997-1027 [DOI] [Details]
(2008) 'Hybrids of 1-deoxynojirimycin and aryl-1,2,3-triazoles and biological studies related to angiogenesis'
Zhao, YX,Zhou, Y,O'Boyle, KM,Murphy, PV (2008) 'Hybrids of 1-deoxynojirimycin and aryl-1,2,3-triazoles and biological studies related to angiogenesis'. Bioorganic & Medicinal Chemistry, 16 (1212):6333-6337 [Details]
(2008) 'Synthesis of sugar-lactams from azides of glucuronic acid (vol 342, pg 1953, 2007)'
Loukou, C,Tosin, M,Miiller-Bunz, H,Murphy, PV (2008) 'Synthesis of sugar-lactams from azides of glucuronic acid (vol 342, pg 1953, 2007)'. Carbohydrate Research, 343 (22):412-413 [Details]
(2008) 'Synthesis of somatostatin mimetics based on 1-deoxynojirimycin'
Chagnault, V,Lalot, J,Murphy, PV (2008) 'Synthesis of somatostatin mimetics based on 1-deoxynojirimycin'. Chemmedchem, 3 (77):1071-1076 [Details]
(2008) 'New access to 1-deoxynojirimycin derivatives via azide-alkene cycloaddition'
Zhou, Y.,Murphy, P.V. (2008) 'New access to 1-deoxynojirimycin derivatives via azide-alkene cycloaddition'. Organic Letters, 10 (17) [Details]
(2008) 'Hybrid angiogenesis inhibitors: Synthesis and biological evaluation of bifunctional compounds based on 1-deoxynojirimycin and aryl-1,2,3-triazoles'
Zhou, Y,Zhao, Y,O'Boyle, KM,Murphy, PV (2008) 'Hybrid angiogenesis inhibitors: Synthesis and biological evaluation of bifunctional compounds based on 1-deoxynojirimycin and aryl-1,2,3-triazoles'. Bioorganic & Medicinal Chemistry Letters, 18 (33):954-958 [Details]
(2008) 'Hybrid angiogenesis inhibitors: synthesis and biological evaluation of bifunctional compounds comprised of 1-deoxynojirimycin and 5-aryl-1,2,3-triazoles'
Zhou, Y.,Zhao,Y.,O' Boyle,K.M.,Murphy,P.V. (2008) 'Hybrid angiogenesis inhibitors: synthesis and biological evaluation of bifunctional compounds comprised of 1-deoxynojirimycin and 5-aryl-1,2,3-triazoles'. Bioorganic and Medicinal Chemistry Letters, 18 :954-958 [DOI] [Details]
(2008) 'Synthesis of Novel Macrolactam and Macroketone Analogues of Migrastatin from D-Glucal and Comparison with Macrolactone and Acyclic Analogues: A Dorrigocin A Congener is a Potent Inhibitor of Gastric Cancer Cell Migration'
Anquetin,G, Horgan,G, Rawe,S, Murray,D, Madden,A, MacMathuna,P, Doran,P, Murphy,P.V. (2008) 'Synthesis of Novel Macrolactam and Macroketone Analogues of Migrastatin from D-Glucal and Comparison with Macrolactone and Acyclic Analogues: A Dorrigocin A Congener is a Potent Inhibitor of Gastric Cancer Cell Migration'. European Journal of Organic Chemistry, 11 :1953-1958 [Details]
(2008) 'Synthesis of novel migrastatin and dorrigocin A analogues from D-glucal'
Anquetin, G.,Rawe, S.L.,McMahon, K.,Murphy, E.P.,Murphy, P.V. (2008) 'Synthesis of novel migrastatin and dorrigocin A analogues from D-glucal'. Chemistry - A European Journal, 14 (5) [Details]
(2008) 'Synthesis of novel glycophanes derived from glucuronic acid by ring closing alkene and alkyne metathesis'
Doyle,D.,Murphy, P.V. (2008) 'Synthesis of novel glycophanes derived from glucuronic acid by ring closing alkene and alkyne metathesis'. Carbohydrate Research, 343 (15) [Details]
(2007) 'Inhibition of endothelial cell proliferation by per-O-acetylated mannose conjugates'
Zaric,V., Doyle, D., Murphy, P.V., O'Boyle, K.M. (2007) 'Inhibition of endothelial cell proliferation by per-O-acetylated mannose conjugates'. Anticancer Research, 27 (3 A) [Details]
(2007) 'The synthesis of cyclic imidates from amides of glucuronic acid and investigation of glycosidation reactions'
Cronin,L.,Tosin, M.,Muller-Bunz, H.,Murphy, P.V. (2007) 'The synthesis of cyclic imidates from amides of glucuronic acid and investigation of glycosidation reactions'. Carbohydrate Research, 342 (1) [Details]
(2007) 'Selective protecting group manipulations on the 1-deoxynojirimycin scaffold'
Danieli,E.,Lalot, J.,Murphy, P.V. (2007) 'Selective protecting group manipulations on the 1-deoxynojirimycin scaffold'. Tetrahedron, 63 (29) [Details]
(2007) 'Synthesis of macrolide-saccharide hybrids by ring-closing metathesis of precursors derived from glycitols and benzoic acids'
Matos, M.-C.,Murphy, P.V. (2007) 'Synthesis of macrolide-saccharide hybrids by ring-closing metathesis of precursors derived from glycitols and benzoic acids'. Journal of Organic Chemistry, 72 (5) [Details]
(2007) 'Glycosidation-anomerisation reactions of 6,1-anhydroglucopyranuronic acid and anomerisation of beta-D-glucopyranosiduronic acids promoted by SnCl4'
O'Brien, C,Polakova, M,Pitt, N,Tosin, M,Murphy, PV (2007) 'Glycosidation-anomerisation reactions of 6,1-anhydroglucopyranuronic acid and anomerisation of beta-D-glucopyranosiduronic acids promoted by SnCl4'. Chemistry-a European Journal, 13 (33):902-909 [Details]
(2007) 'Synthesis of sugar-lactams from azides of glucuronic acid'
Loukou, C, Tosin,M, Müller-Bunz,H, Murphy,P.V. (2007) 'Synthesis of sugar-lactams from azides of glucuronic acid'. Carbohydrate Research Special issue-Glycomimetics, 342 :1953-1959 [DOI] [Details]
(2007) 'Peptidomimetics, glycomimetics and scaffolds from carbohydrate building blocks'
Murphy, P.V. (2007) 'Peptidomimetics, glycomimetics and scaffolds from carbohydrate building blocks'. European Journal of Organic Chemistry, (25) [Details]
(2006) 'Syntheses of peptidomimetics based on pyranose and polyhydroxylated piperidine scaffolds'
Murphy,P.V.,Dunne, J.L. (2006) 'Syntheses of peptidomimetics based on pyranose and polyhydroxylated piperidine scaffolds'. Current Organic Synthesis, 3 (4) [Details]
(2006) 'N-glycosyl-thiophene-2-carboxamides: synthesis, structure and effects on the growth of diverse cell types'
Rawe, SL,Doyle, D,Zaric, V,Rozas, I,McMahon, K,Tosin, M,Bunz, HM,Murphy, EP,O'Boyle, KM,Murphy, PV (2006) 'N-glycosyl-thiophene-2-carboxamides: synthesis, structure and effects on the growth of diverse cell types'. Carbohydrate Research, 341 (1010):1370-1390 [Details]
(2006) 'N-Glycosyl-thiophene-2-carboxamides: Effects on endothelial cell growth in the presence and absence of bFGF - A significant increase in potency using per-O-acetylated sugar analogues'
Rawe, SL,Zaric, V,O'Boyle, KM,Murphy, PV (2006) 'N-Glycosyl-thiophene-2-carboxamides: Effects on endothelial cell growth in the presence and absence of bFGF - A significant increase in potency using per-O-acetylated sugar analogues'. Bioorganic & Medicinal Chemistry Letters, 16 :1316-1319 [DOI] [Details]
(2005) 'Synthesis of structurally diverse and defined bivalent mannosides on saccharide scaffolding'
Tosin,M.,Gouin, S.G.,Murphy, P.V. (2005) 'Synthesis of structurally diverse and defined bivalent mannosides on saccharide scaffolding'. Organic Letters, 7 (2) [Details]
(2005) 'Novel synthesis of castanospermine and 1-epicastanospermine'
Cronin, L,Murphy, PV (2005) 'Novel synthesis of castanospermine and 1-epicastanospermine'. Organic Letters, 7 :2691-2693 [DOI] [Details]
(2005) 'The crystal structure of a cyclic glycolipid reveals a carbohydrate-carbohydrate interaction interface'
Murphy, PV,Muller-Bunz, H,Velasco-Torrijos, T (2005) 'The crystal structure of a cyclic glycolipid reveals a carbohydrate-carbohydrate interaction interface'. Carbohydrate Research, 340 (77):1437-1440 [Details]
(2005) 'Synthesis and conformational analysis of novel water soluble macrocycles incorporating carbohydrates, including a beta-cyclodextrin mimic'
Velasco-Torrijos, T,Murphy, PV (2005) 'Synthesis and conformational analysis of novel water soluble macrocycles incorporating carbohydrates, including a beta-cyclodextrin mimic'. Tetrahedron-Asymmetry, 16 :261-272 [DOI] [Details]
(2005) 'Synthesis and structural analysis of the anilides of glucuronic acid and orientation of the groups on the carbohydrate scaffolding'
Tosin, M.,O'Brien, C.,Fitzpatrick, G.M.,Muller-Bunz, H.,Glass, W.K.,Murphy, P.V. (2005) 'Synthesis and structural analysis of the anilides of glucuronic acid and orientation of the groups on the carbohydrate scaffolding'. Journal of Organic Chemistry, 70 (10) [Details]
(2005) 'Synthesis of structurally defined scaffolds for bivalent ligand display based on glucuronic acid anilides. The degree of tertiary amide isomerism and folding depends on the configuration of a glycosyl azide'
Tosin,M.,Murphy, P.V. (2005) 'Synthesis of structurally defined scaffolds for bivalent ligand display based on glucuronic acid anilides. The degree of tertiary amide isomerism and folding depends on the configuration of a glycosyl azide'. Journal of Organic Chemistry, 70 (10) [Details]
(2005) 'A study of the effects of subunit pre-orientation for diarylpyrrole esters; design of new aryl-heteroaryl fluorescent sensors'
Killoran, J.,Gallagher, J.F.,Murphy, P.V.,O'Shea, D.F. (2005) 'A study of the effects of subunit pre-orientation for diarylpyrrole esters; design of new aryl-heteroaryl fluorescent sensors'. New Journal of Chemistry, 29 (10) [Details]
(2005) 'Synthesis of somatostatin mimetics based on the 1-deoxymannojirimycin scaffold'
Gouin, S.G.,Murphy, P.V. (2005) 'Synthesis of somatostatin mimetics based on the 1-deoxymannojirimycin scaffold'. Journal of Organic Chemistry, 70 (21) [Details]
(2005) 'Synthesis of a glycolipid for studying mechanisms of mitochondrial uncoupling proteins'
Gouin, SG,Pilgrim, W,Porter, RK,Murphy, PV (2005) 'Synthesis of a glycolipid for studying mechanisms of mitochondrial uncoupling proteins'. Carbohydrate Research, 340 (88):1547-1552 [Details]
(2004) 'Glycosidation reactions of silyl ethers with conformationally inverted donors derived from glucuronic acid: Stereoselective synthesis of glycosides and 2-deoxyglycosides'
Polakova,M.,Pitt, N.,Tosin, M.,Murphy, P.V. (2004) 'Glycosidation reactions of silyl ethers with conformationally inverted donors derived from glucuronic acid: Stereoselective synthesis of glycosides and 2-deoxyglycosides'. Angewandte Chemie - International Edition, 43 (19) [Details]
(2004) 'Synthesis of a glucuronic acid and glucose conjugate library and evaluation of effects on endothelial cell growth'
Pitt,N.,Duane, R.M.,O' Brien, A.,Bradley, H.,Wilson, S.J.,O' Boyle, K.M.,Murphy, P.V. (2004) 'Synthesis of a glucuronic acid and glucose conjugate library and evaluation of effects on endothelial cell growth'. Carbohydrate Research, 339 (11) [Details]
(2004) 'Synthesis of disaccharides derived from heparin and evaluation of effects on endothelial cell growth and on binding of heparin to FGF-2'
O' Brien, A.,Lynch, C.,O' Boyle, K.M.,Murphy, P.V. (2004) 'Synthesis of disaccharides derived from heparin and evaluation of effects on endothelial cell growth and on binding of heparin to FGF-2'. Carbohydrate Research, 339 (14) [Details]
(2004) 'Conformational effects on glycoside reactivity: Study of the high reactive conformer of glucose'
McDonnell, C.,Lopez, O.,Murphy, P.,Fernandez Bolanos, J.G.,Hazell, R.,Bols, M. (2004) 'Conformational effects on glycoside reactivity: Study of the high reactive conformer of glucose'. Journal of the American Chemical Society, 126 (39) [Details]
(2004) 'Synthesis and X-ray single crystal structure of a bivalent glycocluster'
Tosin, M,Muller-Bunz, H,Murphy, PV (2004) 'Synthesis and X-ray single crystal structure of a bivalent glycocluster'. Chemical Communications, :494-495 [DOI] [Details]
(2004) 'A general synthesis of iminosugars'
McDonnell, C,Cronin, L,O'Brien, JL,Murphy, PV (2004) 'A general synthesis of iminosugars'. Journal of Organic Chemistry, 69 (1010):3565-3568 [Details]
(2004) 'Metathesis of structurally preorganized bivalent carbohydrates. Synthesis of macrocyclic and oligomeric scaffolds'
Velasco-Torrijos,T.,Murphy, P.V. (2004) 'Metathesis of structurally preorganized bivalent carbohydrates. Synthesis of macrocyclic and oligomeric scaffolds'. Organic Letters, 6 (22) [Details]
(2004) 'Synthesis of an iminosugar based peptidomimetic analogue'
Chery, F.,Murphy, P.V. (2004) 'Synthesis of an iminosugar based peptidomimetic analogue'. Tetrahedron Letters, 45 (10) [Details]
(2004) 'Synthesis of peptidomimetics based on iminosugar and beta-D-glucopyranoside scaffolds and inhibiton of HIV-protease'
Chery, F,Cronin, L,O'Brien, JL,Murphy, PV (2004) 'Synthesis of peptidomimetics based on iminosugar and beta-D-glucopyranoside scaffolds and inhibiton of HIV-protease'. Tetrahedron, 60 (3131):6597-6608 [Details]
(2003) 'Confirmation of the structure of a glucono-1,4-lactone derivative obtained from silylation of glucono-1,5-lactone'
Murphy, P.V.,McDonnell, C.,Hamig,L.,Paterson, D.E.,Taylor, R.J.K. (2003) 'Confirmation of the structure of a glucono-1,4-lactone derivative obtained from silylation of glucono-1,5-lactone'. Tetrahedron Asymmetry, 14 (1) [Details]
(2003) 'Synthesis of novel HIV-1 protease inhibitors based on carbohydrate scaffolds'
Murphy, PV,O'Brien, JL,Gorey-Feret, LJ,Smith, AB (2003) 'Synthesis of novel HIV-1 protease inhibitors based on carbohydrate scaffolds'. Tetrahedron, 59 :2259-2271 [DOI] [Details]
(2003) 'Development of carbohydrate-based scaffolds for restricted presentation of recognition groups. Extension to divalent ligands and implications for the structure of dimerized receptors'
Murphy, PV,Bradley, H,Tosin, M,Pitt, N,Fitzpatrick, GM,Glass, WK (2003) 'Development of carbohydrate-based scaffolds for restricted presentation of recognition groups. Extension to divalent ligands and implications for the structure of dimerized receptors'. Journal of Organic Chemistry, 68 (1414):5692-5704 [Details]
(2002) 'Structure-based design and synthesis of HIV-1 protease inhibitors employing beta-D-mannopyranoside scaffolds'
Murphy, PV,O'Brien, JL,Gorey-Feret, LJ,Smith, AB (2002) 'Structure-based design and synthesis of HIV-1 protease inhibitors employing beta-D-mannopyranoside scaffolds'. Bioorganic & Medicinal Chemistry Letters, 12 (1313):1763-1766 [Details]
(2002) 'Identification of novel inhibitors of fibroblast growth factor (FGF-2) binding to heparin and endothelial cell survival from a structurally diverse carbohybrid library'
Murphy, PV,Pitt, N,O'Brien, A,Enright, PM,Dunne, A,Wilson, SJ,Duane, RM,O'Boyle, KM (2002) 'Identification of novel inhibitors of fibroblast growth factor (FGF-2) binding to heparin and endothelial cell survival from a structurally diverse carbohybrid library'. Bioorganic & Medicinal Chemistry Letters, 12 (2222):3287-3290 [Details]
(2002) 'A study of the epoxidation of 6-deoxyhex-5-enopyranosides. 1,5-dicarbonyl derivatives and novel synthetic routes to D-xylo-hexos-5-ulose and D-lyxo-hexos-5-ulose'
Enright, PM,Tosin, M,Nieuwenhuyzen, M,Cronin, L,Murphy, PV (2002) 'A study of the epoxidation of 6-deoxyhex-5-enopyranosides. 1,5-dicarbonyl derivatives and novel synthetic routes to D-xylo-hexos-5-ulose and D-lyxo-hexos-5-ulose'. Journal Of Organic Chemistry, 67 :3733-3741 [DOI] [Details]
(2002) 'Synthesis of alpha-glucuronic acid and amide derivatives in the presence of a participating 2-acyl protecting group'
Tosin, M,Murphy, PV (2002) 'Synthesis of alpha-glucuronic acid and amide derivatives in the presence of a participating 2-acyl protecting group'. Organic Letters, 4 (2121):3675-3678 [Details]
(2002) 'A new route to exo-glycals using the Ramberg-Backlund rearrangement'
Griffin, FK,Paterson, DE,Murphy, PV,Taylor, RJK (2002) 'A new route to exo-glycals using the Ramberg-Backlund rearrangement'. European Journal of Organic Chemistry, (77):1305-1322 [Details]
(2002) 'A new route to exo-glycals using the Ramberg-Bäcklund rearrangement'
Griffin, F.K.,Paterson, D.E.,Murphy, P.V.,Taylor, R.J.K. (2002) 'A new route to exo-glycals using the Ramberg-Bäcklund rearrangement'. European Journal of Organic Chemistry, (7) [Details]
(2001) 'Application of Ugi reactions in synthesis of divalent neoglycoconjugates: Evidence that the sugars are presented in restricted conformation'
Bradley, H., Fitzpatrick, G.,Glass, W.K.,Kunz, H.,Murphy, P.V. (2001) 'Application of Ugi reactions in synthesis of divalent neoglycoconjugates: Evidence that the sugars are presented in restricted conformation'. Organic Letters, 3 (17) [Details]
(2001) 'Stereospecific synthesis of beta-D-allopyrano sides by dihydroxylation of beta-D-erythro-2,3-dideoxyhex-2-enopyranosides'
Murphy, PV,O'Brien, JL,Smith, AB (2001) 'Stereospecific synthesis of beta-D-allopyrano sides by dihydroxylation of beta-D-erythro-2,3-dideoxyhex-2-enopyranosides'. Carbohydrate Research, 334 :327-335 [Details]
(2001) 'Novel synthesis of the glycosidase inhibitor deoxymannojirimycin and of a synthetic precursor D-lyxo-hexos-5-ulose'
O'Brien, JL,Tosin, M,Murphy, PV (2001) 'Novel synthesis of the glycosidase inhibitor deoxymannojirimycin and of a synthetic precursor D-lyxo-hexos-5-ulose'. Organic Letters, 3 :3353-3356 [DOI] [Details]
(2000) 'The reactions of diazo compounds with lactones. Part 2. The reaction of cyclic 2-diazo-1,3-dicarbonyl compounds with diketene: benzofuran formation'
Murphy, PV,O'Sullivan, TJ,Kennedy, BD,Geraghty, NWA (2000) 'The reactions of diazo compounds with lactones. Part 2. The reaction of cyclic 2-diazo-1,3-dicarbonyl compounds with diketene: benzofuran formation'. Journal Of The Chemical Society-Perkin Transactions 1, :2121-2126 [DOI] [Details]
(2000) 'Synthesis of D-hexos-5-uloses by novel in situ hydrolysis of epoxides derived from 6-deoxyhex-5-enopyranosides'
Enright, PM,O'Boyle, KM,Murphy, PV (2000) 'Synthesis of D-hexos-5-uloses by novel in situ hydrolysis of epoxides derived from 6-deoxyhex-5-enopyranosides'. Organic Letters, 2 :3929-3932 [DOI] [Details]
(1998) 'A Ramberg-Backlund approach to exo-glycals'
Griffin,F.K.,Murphy, P.V.,Paterson D.E., Taylor R.J.K. (1998) 'A Ramberg-Backlund approach to exo-glycals'. Tetrahedron Letters, 39 (44) [Details]
(1998) 'The synthesis of novel structural analogues of sialyl Lewis(x)'
Murphy P.V.,Hubbard, R.E.,Manallack, D.T.,Montana, J.G.,Taylor, R.J.K. (1998) 'The synthesis of novel structural analogues of sialyl Lewis(x)'. Tetrahedron Letters, 39 (20) [Details]
(1998) 'Design, Synthesis and Testing of Novel Inhibitors of Cell Adhesion'
Manallack,D.T, Montana,J.G, Murphy, P.V, Hubbard,R.E, Taylor,R.J.K, (1998) 'Design, Synthesis and Testing of Novel Inhibitors of Cell Adhesion'. Proceedings of the European Symposium on Quantitative Structure Activity Relationships: Molecular Modelling and Prediction of Bioactivity, 12th, Copenhagen, Denmark 1998 2000), :371-372 [Details]
(1997) 'The reaction of cyclic 2-diazo-1,3-dicarbonyl compounds with beta- and gamma-lactones: Formation of benzodioxepinones, benzodioxecinones and benzofurans'
Cunningham, PD,Geraghty, NWA,McArdle, PJ,Murphy, PV,OSullivan, TJ (1997) 'The reaction of cyclic 2-diazo-1,3-dicarbonyl compounds with beta- and gamma-lactones: Formation of benzodioxepinones, benzodioxecinones and benzofurans'. Journal Of The Chemical Society-Perkin Transactions 1, :1-4 [Details]
(1996) 'Glycosylation reactions of 2,3,4-tri-O-chlorosulfonyl-beta-L-fucopyranosyl chloride and 2,3,4-tri-O-chlorosulfonyl-beta-D-xylopyranosyl chloride'
Hubbard, RE,Montana, JG,Murphy, PV,Taylor, RJK (1996) 'Glycosylation reactions of 2,3,4-tri-O-chlorosulfonyl-beta-L-fucopyranosyl chloride and 2,3,4-tri-O-chlorosulfonyl-beta-D-xylopyranosyl chloride'. Carbohydrate Research, 287 (22):247-253 [Details]
(1994) 'Metal Catalysed Rearrangement of Cyclopropanespiro- -lactones to 2-Furanones'
Geraghty,N.W.A., Murphy,P.V. (1994) 'Metal Catalysed Rearrangement of Cyclopropanespiro- -lactones to 2-Furanones'. Tetrahedron Lett, (6737) [Details]

Book Chapters

  Year Publication
(2022) 'Exploring the Galectin Network by Light and Fluorescence Microscopy'
Caballero GG, Manning JC, Gabba A, Beckwith D, FitzGerald FG, Kutzner TJ, Ludwig AK, Kaltner H, Murphy PV, Cudic M, Gabius HJ. (2022) 'Exploring the Galectin Network by Light and Fluorescence Microscopy' In: Galectins Methods in Molecular Biology. Humana, New York, NY: Springer. [DOI] [Details]
(2016) 'Lewis Acid Promoted Anomerisation: Recent Developments and Applications'
Murphy, Paul (2016) 'Lewis Acid Promoted Anomerisation: Recent Developments and Applications' In: Carbohydrate Chemistry. :90-123 UK: Royal Society of Chemistry. [DOI] [Details]

Edited Books

  Year Publication
(2017) Carbohydrate Chemistry: Proven Synthetic Methods (Volume 4).
Paul Kovac, Christian Vogel, Paul Murphy (Ed.). (2017) Carbohydrate Chemistry: Proven Synthetic Methods (Volume 4). Boca Raton, FL: CRC Press. [Details]

Abstract

  Year Publication
(2011) Synthesis of macrocycles with embedded carbohydrates for peptidomimetic research.
Zhou, J,Murphy, PV (2011) Synthesis of macrocycles with embedded carbohydrates for peptidomimetic research. Abstract [Details]
(2009) ADHERENCE OF BURKHOLDERIA MULTIVORANS TO LUNG EPITHELIAL CELLS VIA SUGAR RECEPTORS: QUANTIFICATION OF ADHESION BY A NOVEL METHOD USING REAL TIME PCR.
Field-Corbett, C,Torrijos, TV,Murphy, PV,Callaghan, M,McClean, S (2009) ADHERENCE OF BURKHOLDERIA MULTIVORANS TO LUNG EPITHELIAL CELLS VIA SUGAR RECEPTORS: QUANTIFICATION OF ADHESION BY A NOVEL METHOD USING REAL TIME PCR. Abstract [Details]

Editorial

  Year Publication
(2017) Carbohydrate Chemistry Proven Synthetic Methods Volume 4 Introduction.
Murphy, PV,Vogel, C,Murphy, PV (2017) Carbohydrate Chemistry Proven Synthetic Methods Volume 4 Introduction. Editorial [Details]
(2006) Symbiosis in chemistry and biology.
Murphy, PV,Rutledge, PJ (2006) Symbiosis in chemistry and biology. Editorial [DOI] [Details]

Meeting

  Year Publication
(2013) Synthesis of 1,2-cis glycosides via chelation induced anomerisation.
Farrell, MP,Murphy, PV (2013) Synthesis of 1,2-cis glycosides via chelation induced anomerisation. Meeting [Details]
(2013) Tandem allylic azide rearrangement and cycloaddition in the synthesis of iminosugars.
Murphy, PV,Moynihan, L (2013) Tandem allylic azide rearrangement and cycloaddition in the synthesis of iminosugars. Meeting [Details]
(2011) Synthesis of peptidomimetics based on carbohydrate scaffold.
Murphy, PV,Zhou, J (2011) Synthesis of peptidomimetics based on carbohydrate scaffold. Meeting [Details]
(2007) Antiproliferative activity of thiophene sugar conjugates in endothelial cells.
Zaric, V,Rawe, SL,Doyle, D,Murphy, PV,O'Boyle, K (2007) Antiproliferative activity of thiophene sugar conjugates in endothelial cells. Meeting [Details]
(2005) New approaches to polyhydroxylated indolizidines.
Lalot, J,Murphy, PV (2005) New approaches to polyhydroxylated indolizidines. Meeting [Details]
(2002) Synthesis of novel glucuronic acid conjugates and the evaluation of their effects on heparin/heparan sulfate binding to FGF.
O'Brien, A,Pitt, N,Duane, R,Wilson, S,Dunne, A,O'Boyle, KM,Murphy, PV (2002) Synthesis of novel glucuronic acid conjugates and the evaluation of their effects on heparin/heparan sulfate binding to FGF. Meeting [Details]

Reviews

  Year Publication
(2010) Metathesis and Macrocycles with Embedded Carbohydrates.
Jarikote, DV,Murphy, PV (2010) Metathesis and Macrocycles with Embedded Carbohydrates. Reviews [DOI] [Details]

Workshops

  Year Publication
(2009) The effect of dorrigocin and migrastatin analogues on angiogenic marker secretions and cellular processes using a human tumour explant model. COST Action Angiokem) Scientific Meeting.
Cheriyan,D, Tosetto,M, Murray,D, Anquetin,G, Zhou,Y, Doran,P, O'Donoghue, D, Mulcahy,H, Murphy,P.V, O'Sullivan,J. (2009) The effect of dorrigocin and migrastatin analogues on angiogenic marker secretions and cellular processes using a human tumour explant model. COST Action Angiokem) Scientific Meeting. Athens, Greece. Workshops [Details]
(2009) Adherence of Burkholderia Multivorans to Lung Epithelial Cells via Sugar Receptors: Quantification of Adhesion by a Novel Method using Real Time PCR . Pediatric Pulmonology Meeting Abstract.
Field-Corbett, C., Torrijos-Velasco T., Murphy P.V., Callaghan, M., McClean, S. (2009) Adherence of Burkholderia Multivorans to Lung Epithelial Cells via Sugar Receptors: Quantification of Adhesion by a Novel Method using Real Time PCR . Pediatric Pulmonology Meeting Abstract. Workshops [Details]
(2009) Novel Echinomycin Analogues: Biophysical Study of Quinoxaline labelled Glycophanes . 15th European Carbohydrate Symposium Poster presentation: PC94:.
Jarikote,D.V, Li,W , Murphy,P.V. (2009) Novel Echinomycin Analogues: Biophysical Study of Quinoxaline labelled Glycophanes . 15th European Carbohydrate Symposium Poster presentation: PC94:. Vienna, Austria. Workshops [Details]
(2009) The Effect of Dorrigocin and Migrastatin Analogs on Angiogenic and Pro-inflammatory Cytokine Secretion in a Human Colorectal Cancer Tumour Explant Model. Cost Action CM0602: 3rd Workshop: Inhibitors of angiogenesis: design, synthesis and biological exploitation ANGIOKEM.
Cheriyan, M, Tosetto, D, Murray, G, Anquetin, Y, Zhou, P,Doran, O'Donoghue, D, Mulcahy, H, Murphy, P.V, O'Sullivan, J. (2009) The Effect of Dorrigocin and Migrastatin Analogs on Angiogenic and Pro-inflammatory Cytokine Secretion in a Human Colorectal Cancer Tumour Explant Model. Cost Action CM0602: 3rd Workshop: Inhibitors of angiogenesis: design, synthesis and biological exploitation ANGIOKEM. Favignana, Italy. Workshops [Details]
(2008) Synthesis of apicularen A and related salicylic acid macrolide structures as novel antiangiogenic compounds against cancer . Ninth Tetrahedron Symposium: Challenges in Organic and Bioorganic Chemistry, Berkeley,CA, USA. Poster Number: P1.35.
Rountree,J.S.S.,Murphy,P.V. (2008) Synthesis of apicularen A and related salicylic acid macrolide structures as novel antiangiogenic compounds against cancer . Ninth Tetrahedron Symposium: Challenges in Organic and Bioorganic Chemistry, Berkeley,CA, USA. Poster Number: P1.35. Workshops [Details]
(2007) Novel migrastatin analogues reduce gastric tumour cell migration via cytoskeletal rearrangement. 15th United European Gastroenterology Week, Le Palais des Congrès de Paris.
Horgan,G.,Murray,D.W.,Anquetin,G.,Murphy,P.V.,MacMathuna, P.,Doran,P. (2007) Novel migrastatin analogues reduce gastric tumour cell migration via cytoskeletal rearrangement. 15th United European Gastroenterology Week, Le Palais des Congrès de Paris. Paris, France Workshops [Details]
(2007) Identification of novel genetic and chemical determinants of the retinal/hyaloid vasculature development in zebrafish using genetic and chemical screening approaches . Irish Network of Developmental Biology INDB) meeting.
Astudillo,O.,Alvarez,Y.,Waghorne, N.,Murphy,P.V.,Fearon,U.,Kennedy,B. (2007) Identification of novel genetic and chemical determinants of the retinal/hyaloid vasculature development in zebrafish using genetic and chemical screening approaches . Irish Network of Developmental Biology INDB) meeting. UCC Workshops [Details]
(2007) Synthesis of compounds of medicinal interest based on carbohydrates. RSC-SCI-ICI Synthesis III Conference.
Murphy,P.V. (2007) Synthesis of compounds of medicinal interest based on carbohydrates. RSC-SCI-ICI Synthesis III Conference. Cork Workshops [Details]
(2006) Antiproliferative activity of thiophene sugar conjugates in endothelial cells, ,b Global mRNA and Protein Expression Analysis. Research applications in cancer and other diseases and in biopharmaceutical production, Dublin City University.
Zaric,V.,Rawe,S.L.,Doyle,D.,Murphy,P.V.,O'Boyle,K. (2006) Antiproliferative activity of thiophene sugar conjugates in endothelial cells, ,b Global mRNA and Protein Expression Analysis. Research applications in cancer and other diseases and in biopharmaceutical production, Dublin City University. Workshops [Details]
(2006) Carbohydrates in Therapeutics: The role of sugars in drug delivery and drug discovery'. Carbohydrate Guided Synthesis of Bioactive Molecules at the Royal Sociaty of Chemistry Carbohydrate Group Autumn Meeting Biocity.
Murphy,P.V. (2006) Carbohydrates in Therapeutics: The role of sugars in drug delivery and drug discovery'. Carbohydrate Guided Synthesis of Bioactive Molecules at the Royal Sociaty of Chemistry Carbohydrate Group Autumn Meeting Biocity. Nottingham, UK Workshops [Details]
(2006) Carbohydrate Guided Synthesis of Bioactive Molecules,' . Queens University Belfast, Symposium on Synthesis, chemical biology and drug design.
Murphy,P.V. (2006) Carbohydrate Guided Synthesis of Bioactive Molecules,' . Queens University Belfast, Symposium on Synthesis, chemical biology and drug design. Workshops [Details]
(2006) Carbohydrates in synthesis of bioactive molecules. Ocean University of China.
Murphy,P.V. (2006) Carbohydrates in synthesis of bioactive molecules. Ocean University of China. Qindao, China Workshops [Details]
(2006) New approaches towards stereoselective glycoside synthesis. 1st European Chemistry Congress.
Loukou,C, Murphy,P.V. (2006) New approaches towards stereoselective glycoside synthesis. 1st European Chemistry Congress. Budapest Workshops [Details]
(2006) Carbohydrate Guided Bioactive Molecule Synthesis. Arrhenius Laboratories.
Murphy,P.V. (2006) Carbohydrate Guided Bioactive Molecule Synthesis. Arrhenius Laboratories. University of Stockholm, Sweden Workshops [Details]
(2006) Sugars as renewable materials for the synthesis of compounds of biological interest' . EU Workshop,CEDNETS, Insitute of Organic Chemistry, Polish Academy of Sciences.
Murphy,P.V. (2006) Sugars as renewable materials for the synthesis of compounds of biological interest' . EU Workshop,CEDNETS, Insitute of Organic Chemistry, Polish Academy of Sciences. Gdansk, Poland Workshops [Details]
(2006) Carbohydrates in synthesis of bioactive molecules. University of Florence, Italy.
Murphy,P.V. (2006) Carbohydrates in synthesis of bioactive molecules. University of Florence, Italy. Workshops [Details]
(2006) Carbohydrates in synthesis of bioactive molecules. Shanghai Institute of Organic Chemistry.
Murphy,P.V. (2006) Carbohydrates in synthesis of bioactive molecules. Shanghai Institute of Organic Chemistry. Shanghai, China, Workshops [Details]
(2006) Pyranoside and iminosugar scaffolding as a basis for the development of peptidomimetics. ERA Chemistry Workshop on 'Stereo-controlled chemistry related to the solution of major biological problems'.
Murphy,P.V. (2006) Pyranoside and iminosugar scaffolding as a basis for the development of peptidomimetics. ERA Chemistry Workshop on 'Stereo-controlled chemistry related to the solution of major biological problems'. Universidad Autonoma de Madrid, Spain. Workshops [Details]
(2006) Synthesis and anticancer activity of new migrastatin analogs . Abstracts of Papers, 234th ACS National Meeting MEDI-459.
Anquetin,G.,Rawe,S.L.,Murphy,P.V. (2006) Synthesis and anticancer activity of new migrastatin analogs . Abstracts of Papers, 234th ACS National Meeting MEDI-459. Boston, MA, United States, Workshops [Details]
(2006) Natural Product Agents for Angiogenesis and Cancer, Guillaume Anquetin, 1st European Chemistry Congress.
Rawe,S.L.,Murphy,P.V. (2006) Natural Product Agents for Angiogenesis and Cancer, Guillaume Anquetin, 1st European Chemistry Congress. Budapest Workshops [Details]
(2006) Carbohydrates in synthesis of bioactive molecules. Medical School, Peking University.
Murphy,P.V. (2006) Carbohydrates in synthesis of bioactive molecules. Medical School, Peking University. Beijing, China Workshops [Details]
(2006) Gordon Research Conference, Angiogenesis and Microcirculation.
Murphy,P.V. (2006) Gordon Research Conference, Angiogenesis and Microcirculation. Salve Regina University, Newport Rhode Island Workshops [Details]
(2005) Synthetic approaches to cell proliferation inhibitors. Abstracts of Papers, 230th ACS National Meeting, Washington, United States, CARB-66 MEDI 453.
Rawe,S.L., Zaric,V.,O' Boyle,K.M.,Murphy,P.V. (2005) Synthetic approaches to cell proliferation inhibitors. Abstracts of Papers, 230th ACS National Meeting, Washington, United States, CARB-66 MEDI 453. Workshops [Details]
(2005) Synthesis of peptidomimetics based on 1-deoxymannojirimycin. Abstracts of Papers, 230th ACS National Meeting CARB-87 Oral contribution).
Gouin,S.G.,Murphy,P.V. (2005) Synthesis of peptidomimetics based on 1-deoxymannojirimycin. Abstracts of Papers, 230th ACS National Meeting CARB-87 Oral contribution). Washington, United States Workshops [Details]
(2005) Structural analysis of thiophenecarboxamides showing intramolecular NH-acetylene interaction . Abstracts of Papers, 230th ACS National Meeting ORGN 511.
Rawe,S.L.,Murphy,P.V. (2005) Structural analysis of thiophenecarboxamides showing intramolecular NH-acetylene interaction . Abstracts of Papers, 230th ACS National Meeting ORGN 511. Washington, United States, Workshops [Details]
(2005) Bioactive molecules derived from Carbohydrates. University of Virginia, Charlottesville, USA.
Murphy,P.V. (2005) Bioactive molecules derived from Carbohydrates. University of Virginia, Charlottesville, USA. Workshops [Details]
(2005) Synthesis of peptidomimetics based on 1-deoxymannojirimycin. FEBS Summer School, Chemistry meets Biology.
Gouin,S.G.,Murphy,P.V. (2005) Synthesis of peptidomimetics based on 1-deoxymannojirimycin. FEBS Summer School, Chemistry meets Biology. Spetses, Greece Workshops [Details]
(2005) Synthesis of castanospermine and related iminosugars. Abstracts of Papers, 230th ACS National Meeting, Washington, United States, August 2005, CARB-86 Oral presentation).
Murphy,P.V.,Cronin,L. (2005) Synthesis of castanospermine and related iminosugars. Abstracts of Papers, 230th ACS National Meeting, Washington, United States, August 2005, CARB-86 Oral presentation). Workshops [Details]
(2005) Carbohydrates and natural products of biomedical interest. National Centre for Biomedical Engineering and Science.
Murphy,P.V. (2005) Carbohydrates and natural products of biomedical interest. National Centre for Biomedical Engineering and Science. NUI-Galway Workshops [Details]
(2005) Saccharides: New Synthesis, Structure and Bioactive Molecules . Organic Chemistry Symposium.
Murphy,P.V. (2005) Saccharides: New Synthesis, Structure and Bioactive Molecules . Organic Chemistry Symposium. University of Nottingham, UK, Workshops [Details]
(2005) New approaches to polyhydroxylated indolizidines. Abstracts of Papers, 230th ACS National Meeting, Washington, United States, CARB-66 Poster presentation.
Lalot,J.,Murphy,P.V. (2005) New approaches to polyhydroxylated indolizidines. Abstracts of Papers, 230th ACS National Meeting, Washington, United States, CARB-66 Poster presentation. Workshops [Details]
(2005) Synthesis of castanospermine and related iminosugars. Abstracts of Papers, 230th ACS National Meeting, Washington, United States, CARB-86.
Murphy,P.V.,Cronin,L. (2005) Synthesis of castanospermine and related iminosugars. Abstracts of Papers, 230th ACS National Meeting, Washington, United States, CARB-86. Workshops [Details]
(2005) Synthesis of bivalent ligands for lattice formation. FEBS Summer School, Chemistry meets Biology.
Velasco-Torrijos,T.,Murphy,P.V. (2005) Synthesis of bivalent ligands for lattice formation. FEBS Summer School, Chemistry meets Biology. Spetses, Greece Workshops [Details]
(2004) The biological evaluation of disaccharides derived from heparin,. Glycobiology.
Duane, R. M., O'Brien A., Lynch, C., Murphy, P. V., O' Boyle, K. M., (2004) The biological evaluation of disaccharides derived from heparin,. Glycobiology. Workshops [Details]
(2004) Glycosidation reactions of silyl ethers with conformationally inverted donors . Stereoselective glycoside and 2-deoxyglycoside synthesis, 22nd International Carbohydrate Symposium.
Murphy,P.V. (2004) Glycosidation reactions of silyl ethers with conformationally inverted donors . Stereoselective glycoside and 2-deoxyglycoside synthesis, 22nd International Carbohydrate Symposium. Glasgow, UK. Workshops [Details]
(2004) Novel syntheses and structure in carbohydrate chemistry. Department of Chemistry and Chemical Biology.
Murphy,P.V. (2004) Novel syntheses and structure in carbohydrate chemistry. Department of Chemistry and Chemical Biology. Cornell University, US Workshops [Details]
(2003) Stereoselective Synthesis and Modulators of Cellular Behaviour Based on Glucuronic Acid. Universität Mainz, Germany.
Murphy,P.V. (2003) Stereoselective Synthesis and Modulators of Cellular Behaviour Based on Glucuronic Acid. Universität Mainz, Germany. Workshops [Details]
(2003) Synthesis of 1,2-cis glycosides in the presence of a 2-acyl group Introduction of 6,1-lactones as glycosyl donors' . Eurotron Glycosciences Conference, EGC-5 on Synthesis of biologically important carbohydrates and analogues.
Murphy,P.V. (2003) Synthesis of 1,2-cis glycosides in the presence of a 2-acyl group Introduction of 6,1-lactones as glycosyl donors' . Eurotron Glycosciences Conference, EGC-5 on Synthesis of biologically important carbohydrates and analogues. Workshops [Details]
(2003) Syntheses and Identification of Bioactive Substances Based on Carbohydrates. Universität Konstanz, Germany.
Murphy,P.V. (2003) Syntheses and Identification of Bioactive Substances Based on Carbohydrates. Universität Konstanz, Germany. Workshops [Details]
(2003) The synthesis and structural evaluation of restricted divalent carbohydrates . Abstracts of Papers, 226th ACS National Meeting, New York, NY, United States, CARB-073.
Tosin, M., Murphy, P. V. (2003) The synthesis and structural evaluation of restricted divalent carbohydrates . Abstracts of Papers, 226th ACS National Meeting, New York, NY, United States, CARB-073. Workshops [Details]
(2003) The synthesis of restricted glycoclusters. Chemical Biology Workshop, Centre for Synthesis and Chemical Biology, UCD.
Murphy,P.V. (2003) The synthesis of restricted glycoclusters. Chemical Biology Workshop, Centre for Synthesis and Chemical Biology, UCD. Workshops [Details]
(2003) New approaches to glycoside synthesis and multivalent ligand design . University of Aarhus, Denmark.
Murphy,P.V. (2003) New approaches to glycoside synthesis and multivalent ligand design . University of Aarhus, Denmark. Workshops [Details]
(2003) Application of 6,1-lactones in glycoside synthesis . Abstracts of Papers, 226th ACS National Meeting CARB-002. Oral Contribution.
Murphy, P. V., Tosin, M., Poláková, M., Pitt, N. (2003) Application of 6,1-lactones in glycoside synthesis . Abstracts of Papers, 226th ACS National Meeting CARB-002. Oral Contribution. New York, NY, United States Workshops [Details]
(2003) Development of glycoconjugate based inhibitors of endothelial cell proliferation. Conway Institute Cancer Biology Group Meeting.
Murphy,P.V. (2003) Development of glycoconjugate based inhibitors of endothelial cell proliferation. Conway Institute Cancer Biology Group Meeting. University College Dublin Workshops [Details]
(2003) Syntheses and Identification of Bioactive Substances Based on Carbohydrates. Universität Hannover, Germany.
Murphy,P.V. (2003) Syntheses and Identification of Bioactive Substances Based on Carbohydrates. Universität Hannover, Germany. Workshops [Details]
(2003) Syntheses and Identification of Bioactive Substances Based on Carbohydrates. Universität Regensburg, Germany.
Murphy,P.V. (2003) Syntheses and Identification of Bioactive Substances Based on Carbohydrates. Universität Regensburg, Germany. Workshops [Details]
(2003) Syntheses and Identification of Bioactive Substances Based on Carbohydrates. Universität Bayreuth, Germany.
Murphy,P.V. (2003) Syntheses and Identification of Bioactive Substances Based on Carbohydrates. Universität Bayreuth, Germany. Workshops [Details]
(2002) Synthesis of novel glucuronic acid conjugates and the evaluation of their effects on heparin/heparan sulfate binding to FGF . Abstracts of Papers, 224th ACS National Meeting, Boston, MA, United States, MEDI-191.
Brien, A , Pitt, N , Duane, R, Wilson, S, Dunne, A , O'Boyle, K.M, Murphy, P. V. (2002) Synthesis of novel glucuronic acid conjugates and the evaluation of their effects on heparin/heparan sulfate binding to FGF . Abstracts of Papers, 224th ACS National Meeting, Boston, MA, United States, MEDI-191. Workshops [Details]
(2002) Novel Modulators of Proteoglycan Mediated Signal Transduction, Enzyme Inhibitors and Conformationally Restricted Divalent Ligands for Receptor Clustering. University of York.
Murphy,P.V. (2002) Novel Modulators of Proteoglycan Mediated Signal Transduction, Enzyme Inhibitors and Conformationally Restricted Divalent Ligands for Receptor Clustering. University of York. Workshops [Details]
(2002) Progress in the Design, Synthesis and Biological Evaluation of Small Heparan Sulfate Mimetics and a New Synthesis of Aza-Sugars . Royal Society of Chemistry, Drugs from Natural Products Symposium.
Murphy,P.V. (2002) Progress in the Design, Synthesis and Biological Evaluation of Small Heparan Sulfate Mimetics and a New Synthesis of Aza-Sugars . Royal Society of Chemistry, Drugs from Natural Products Symposium. Trinity College Dublin Workshops [Details]
(2002) Progress in the synthesis of five- and six-membered ring azasugars . Abstracts of Papers, 224th ACS National Meeting, Boston, MA, United States, MEDI-397.
McDonnell, C, Cronin, L, O'Brien, J.L., Murphy, P. V. (2002) Progress in the synthesis of five- and six-membered ring azasugars . Abstracts of Papers, 224th ACS National Meeting, Boston, MA, United States, MEDI-397. Workshops [Details]
(2002) Carbohydrates and Glycoconjugates in Chemistry and Biology. Conway Institute Festival of Research.
Murphy,P.V. (2002) Carbohydrates and Glycoconjugates in Chemistry and Biology. Conway Institute Festival of Research. University College Dublin Workshops [Details]
(2002) Natural Products-Lead Structures'. Graduiertenkolleg Medicinal Chemistry DFG) and the International Quality Network Medicinal Chemistry Summer School, Universität Regensburg, Germany.
Murphy,P.V. (2002) Natural Products-Lead Structures'. Graduiertenkolleg Medicinal Chemistry DFG) and the International Quality Network Medicinal Chemistry Summer School, Universität Regensburg, Germany. Workshops [Details]
(2001) Use of glycals and glycosyl azides in synthesis of bioactive carbohydrates .
Murphy,P.V. (2001) Use of glycals and glycosyl azides in synthesis of bioactive carbohydrates . Universität Mainz, Germany Workshops [Details]
(2001) Towards regulation of GAG binding proteins, novel enzyme inhibitors and topographically restricted multivalent ligands. Trinity College Dublin.
Murphy,P.V. (2001) Towards regulation of GAG binding proteins, novel enzyme inhibitors and topographically restricted multivalent ligands. Trinity College Dublin. Workshops [Details]
(2001) Novel glycoconjugates, interesting structures, and effects on binding of heparin to fibroblast growth factor. Joint Meeting Between the Section of Clinical Immunology and Allergy and the Education and Research Centre.
Murphy,P.V. (2001) Novel glycoconjugates, interesting structures, and effects on binding of heparin to fibroblast growth factor. Joint Meeting Between the Section of Clinical Immunology and Allergy and the Education and Research Centre. St. Vincent's University Hospital, UCD Workshops [Details]
(2001) Toward synthesis of monvalent and multivalent glyconjugate Libraries Eurocarb XI). 11th European Carbohydrate Symposium.
Murphy,P.V. (2001) Toward synthesis of monvalent and multivalent glyconjugate Libraries Eurocarb XI). 11th European Carbohydrate Symposium. Lisbon Workshops [Details]
(2000) Novel Synthesis of Divalent Glycoconjugates. 20th International Carbohydrate Symposium.
Murphy,P.V. (2000) Novel Synthesis of Divalent Glycoconjugates. 20th International Carbohydrate Symposium. Hamburg Workshops [Details]
(2000) Glasscyclics EU Network Meeting, Methods for the synthesis of bioactive carbohydrates.
Murphy,P.V. (2000) Glasscyclics EU Network Meeting, Methods for the synthesis of bioactive carbohydrates. Konstanz, Germany, Workshops [Details]
(1999) Euchem Conference III, Synthesis of Bioactive Molecules.
Murphy,P.V. (1999) Euchem Conference III, Synthesis of Bioactive Molecules. Galway Workshops [Details]
(1999) Synthesis of Sialyl Lewis X Mimetics as Potential Anti-inflammatory Agents . Dublin City University.
Murphy,P.V. (1999) Synthesis of Sialyl Lewis X Mimetics as Potential Anti-inflammatory Agents . Dublin City University. Workshops [Details]
(1999) Synthesis of Novel Sialyl Lewis X mimetics. Royal Society of Chemistry Carbohydrate Group Spring Meeting Carbohydrates as the Basis for Therapeutic Agents) University of York.
Murphy,P.V. (1999) Synthesis of Novel Sialyl Lewis X mimetics. Royal Society of Chemistry Carbohydrate Group Spring Meeting Carbohydrates as the Basis for Therapeutic Agents) University of York. Workshops [Details]
(1998) Carbohydrates and Medicinal Chemistry. University College Galway.
Murphy,P.V. (1998) Carbohydrates and Medicinal Chemistry. University College Galway. Workshops [Details]
(1998) CERC III, Young Chemists Meeting.
Murphy,P.V. (1998) CERC III, Young Chemists Meeting. Hanover, Germany Workshops [Details]
(1997) CERC III, Young Chemists Meeting.
Murphy,P.V. (1997) CERC III, Young Chemists Meeting. Grenoble, France Workshops [Details]
(1997) Formation and Rearrangement of Cyclopropanespiro- -lactones from Diketene. Royal Society of Chemistry, Autumn Meeting, Pre-doctoral Symposium, September 1992.
Murphy,P.V. (1997) Formation and Rearrangement of Cyclopropanespiro- -lactones from Diketene. Royal Society of Chemistry, Autumn Meeting, Pre-doctoral Symposium, September 1992. Trinity College Dublin, Workshops [Details]

Professional Associations

  Association Function From / To
Institute of Chemistry of Ireland Fellow /
Royal Society of Chemistry Fellow /
American Chemical Society Member /

Recent Postgraduate Students

  Graduation Name Degree Primary Supervisor
2016 Louise Kerins PhD Y
2016 Anthony McDonagh PhD Y
2016 Sinclair Sweeney PhD Y
2015 Shane O'Sullivan PhD Y
2011 Michelle McKinney Msc Y
2014 Mark Farrell PhD Y
2013 Lorna Moynihan PhD Y
2012 Caitriona Farrell PhD Y
2014 Stephen Barron PhD Y

Modules Taught

  Term/Year Module Title Module Code Subject / Desc
3 Organic Chemistry CH311 Chemistry
4 Research Project CH4101 Chemistry
4 Synthesis, Organometallic and Analytical Chemistry CH4102 (CH449) Chemistry
Year 4 Biopharmaceutical Chemistry and Industrial Biochemistry CH4109 Biopharmaceutical Chemistry
5 (Master/PhD) Advanced Carbohydrate Chemistry CH503 Chemistry
2 Organic Chemistry CH202 Chemistry