Biological and Chemical Sciences

Professor Noel Lowndes

B.A. (Dub), Ph.D. (Glas.)

Contact Details

Chair, Biochemistry & Director
Genome Stability Laboratory
Biochemistry/School of Natural Science
National University of Ireland Galway
T: (091) 492415
E: noel.lowndes@nuigalway.ie
https://www.chromosome.ie/researchers/lowndes/

Biography

Professor Lowndes is an expert on the mechanisms of cell cycle control and the DNA damage-response, a thorough understanding of which will translate into improved cancer diagnosis and therapeutic regimes. In 2001, he was appointed to the Chair of Biochemistry at the National University of Ireland Galway and founded the Genome Stability Laboratory, which focuses on the mechanisms of sensing and responding to DNA damage using yeast and vertebrate cells. More specifically, the two major areas of current focus are the function and regulation of checkpoint mediators (Rad9/53BP1) and PIK kinases, (Mec1/ATR and ATM).

Professor Lowndes has played a pivotal role in positioning NUI Galway at the forefront of cancer biology within Ireland. In particular, he has led the development of an internationally recognised and expanding cluster of excellence in cell cycle and genome stability studies and is the founding director of the Centre of Chromosome Biology (http://www.chromosome.ie/). The CCB currently consists of ten laboratory heads who direct over 80 full time researchers engaged in studies related to the function and regulation of checkpoints, centromeres, centrosomes, chromatin, DSB repair, DNA synthesis, nucleoli, trans lesion DNA synthesis and telomeres.

Nearly 40 early stage researchers have received training under Professor Lowndes’ mentorship, including 12 completed PhD. Eight PhD students are currently being supervised by Prof Lowndes.

Research Interests

Cancer Biology / Cellular responses to DNA damage / Cell cycle control

Peer Reviewed Journals

	Year	Publication
	(2015)	'BRCA1 Is Required for Maintenance of Phospho-Chk1 and G(2)/M Arrest during DNA Cross-Link Repair in DT40 Cells' Draga, M,Madgett, EB,Vandenberg, CJ,du Plessis, D,Kaufmann, A,Werler, P,Chakraborty, P,Lowndes, NF,Hiom, K (2015) 'BRCA1 Is Required for Maintenance of Phospho-Chk1 and G(2)/M Arrest during DNA Cross-Link Repair in DT40 Cells'. Molecular And Cellular Biology, 35 :3829-3840 [DOI] [Details]
	(2014)	'Hypoxia Enhances the Radioresistance of Mouse Mesenchymal Stromal Cells' Sugrue, T,Lowndes, NF,Ceredig, R (2014) 'Hypoxia Enhances the Radioresistance of Mouse Mesenchymal Stromal Cells'. Stem Cells, 32 :2188-2200 [DOI] [Details]
	(2014)	'Induction of homologous recombination between sequence repeats by the activation induced cytidine deaminase (AID) protein' Buerstedde, JM,Lowndes, N,Schatz, DG (2014) 'Induction of homologous recombination between sequence repeats by the activation induced cytidine deaminase (AID) protein'. eLife, 3 [DOI] [Details]
	(2014)	'Rational design and validation of a Tip60 histone acetyltransferase inhibitor' Gao C, Bourke E, Scobie M, Famme MA, Koolmeister T, Helleday T, Eriksson LA, Lowndes NF, Brown JA (2014) 'Rational design and validation of a Tip60 histone acetyltransferase inhibitor'. Scientific reports, 4 [DOI] [Details]
	(2014)	'Induction of homologous recombination between sequence repeats by the activation induced cytidine deaminase (AID) protein' Buerstedde JM, Lowndes N, Schatz DG (2014) 'Induction of homologous recombination between sequence repeats by the activation induced cytidine deaminase (AID) protein'. eLife, 3 [Details]
	(2014)	'The RSF1 Histone-Remodelling Factor Facilitates DNA Double-Strand Break Repair by Recruiting Centromeric and Fanconi Anaemia Proteins' Pessina, F,Lowndes, NF (2014) 'The RSF1 Histone-Remodelling Factor Facilitates DNA Double-Strand Break Repair by Recruiting Centromeric and Fanconi Anaemia Proteins'. Plos Biology, 12 [DOI] [Details]
	(2014)	'Rational design and validation of a Tip60 histone acetyltransferase inhibitor' Gao, C.,Bourke, E.,Scobie, M.,Famme, M. A.,Koolmeister, T.,Helleday, T.,Eriksson, L. A.,Lowndes, N. F.,Brown, J. A. (2014) 'Rational design and validation of a Tip60 histone acetyltransferase inhibitor'. Sci Rep, 4 [Details]
	(2013)	'Mesenchymal stromal cells: radio-resistant members of the bone marrow' Sugrue T, Lowndes NF, Ceredig R. (2013) 'Mesenchymal stromal cells: radio-resistant members of the bone marrow'. Immunology And Cell Biology, 91 (1):5-11 [DOI] [Details]
	(2013)	'Repression of G1/S transcription is mediated via interaction of the GTB motifs of Nrm1 and Whi5 with Swi6' Travesa A, Kalashnikova TI, de Bruin RA, Cass SR, Chahwan C, Lee DE, Lowndes NF, Wittenberg C (2013) 'Repression of G1/S transcription is mediated via interaction of the GTB motifs of Nrm1 and Whi5 with Swi6'. Molecular And Cellular Biology, 33 (8):1476-1486 [DOI] [Details]
	(2013)	'Multiple facets of the DNA damage response contribute to the radioresistance of mouse mesenchymal stromal cell lines' Sugrue T, Brown JA, Lowndes NF, Ceredig R (2013) 'Multiple facets of the DNA damage response contribute to the radioresistance of mouse mesenchymal stromal cell lines'. Stem Cells and Development, 31 (1):137-145 [DOI] [Details]
	(2013)	'Binding Specificity of the G1/S Transcriptional Regulators in Budding Yeast' Harris, MR,Lee, D,Farmer, S,Lowndes, NF,de Bruin, RAM (2013) 'Binding Specificity of the G1/S Transcriptional Regulators in Budding Yeast'. Plos One, 8 [DOI] [Details]
	(2013)	'Site-Specific Phosphorylation of the DNA Damage Response Mediator Rad9 by Cyclin-Dependent Kinases Regulates Activation of Checkpoint Kinase 1' Abreu, CM,Kumar, R,Hamilton, D,Dawdy, AW,Creavin, K,Eivers, S,Finn, K,Balsbaugh, JL,O'Connor, R,Kiely, PA,Shabanowitz, J,Hunt, DF,Grenon, M,Lowndes, NF (2013) 'Site-Specific Phosphorylation of the DNA Damage Response Mediator Rad9 by Cyclin-Dependent Kinases Regulates Activation of Checkpoint Kinase 1'. Plos Genetics, 9 (4) [DOI] [Details]
	(2013)	'Multiple facets of the DNA damage response contribute to the radioresistance of mouse mesenchymal stromal cell lines' Sugrue, T.,Brown, J. A.,Lowndes, N. F.,Ceredig, R. (2013) 'Multiple facets of the DNA damage response contribute to the radioresistance of mouse mesenchymal stromal cell lines'. Stem Cells, 31 (11):137-45 [Details]
	(2013)	'ATR Activates the S-M Checkpoint during Unperturbed Growth to Ensure Sufficient Replication Prior to Mitotic Onset' Eykelenboom, JK,Harte, EC,Canavan, L,Pastor-Peidro, A,Calvo-Asensio, I,Llorens-Agost, M,Lowndes, NF (2013) 'ATR Activates the S-M Checkpoint during Unperturbed Growth to Ensure Sufficient Replication Prior to Mitotic Onset'. Cell Reports, 5 :1095-1107 [DOI] [Details]
	(2012)	'Co-mutation of histone H2AX S139A with Y142A rescues Y142A-induced ionising radiation sensitivity' Brown, J. A.,Eykelenboom, J. K.,Lowndes, N. F. (2012) 'Co-mutation of histone H2AX S139A with Y142A rescues Y142A-induced ionising radiation sensitivity'. FEBS Open Bio, 2 :313-7 [Details]
	(2012)	'ATR-ATRIP Kinase Complex Triggers Activation of the Fanconi Anemia DNA Repair Pathway' Shigechi, T,Tomida, J,Sato, K,Kobayashi, M,Eykelenboom, JK,Pessina, F,Zhang, YB,Uchida, E,Ishiai, M,Lowndes, NF,Yamamoto, K,Kurumizaka, H,Maehara, Y,Takata, M (2012) 'ATR-ATRIP Kinase Complex Triggers Activation of the Fanconi Anemia DNA Repair Pathway'. Cancer Research, 72 :1149-1156 [DOI] [Details]
	(2012)	'Co-mutation of histone H2AX S139A with Y142A rescues Y142A-induced ionising radiation sensitivity' Brown, JAL,Eykelenboom, JK,Lowndes, NF (2012) 'Co-mutation of histone H2AX S139A with Y142A rescues Y142A-induced ionising radiation sensitivity'. FEBS open bio, 2 :313-317 [DOI] [Details]
	(2012)	'Co-mutation of histone H2AX S139A with Y142A rescues Y142A-induced ionising radiation sensitivity' Brown JA, Eykelenboom JK, Lowndes NF (2012) 'Co-mutation of histone H2AX S139A with Y142A rescues Y142A-induced ionising radiation sensitivity'. FEBS open bio, 2 :313-317 [DOI] [Details]
	(2011)	'Eukaryotic DNA damage checkpoint activation in response to double-strand breaks' Finn K, Lowndes NF, Grenon M (2011) 'Eukaryotic DNA damage checkpoint activation in response to double-strand breaks'. Life Sciences, [DOI] [Details]
	(2011)	'Modification of Histones by Sugar beta-N-Acetylglucosamine (GlcNAc) Occurs on Multiple Residues, Including Histone H3 Serine 10, and Is Cell Cycle-regulated' Zhang, SS,Roche, K,Nasheuer, HP,Lowndes, NF (2011) 'Modification of Histones by Sugar beta-N-Acetylglucosamine (GlcNAc) Occurs on Multiple Residues, Including Histone H3 Serine 10, and Is Cell Cycle-regulated'. Journal Of Biological Chemistry, 286 :37483-37495 [DOI] [Details]
	(2011)	'Regulation of the DNA Damage Response and Gene Expression by the Dot1L Histone Methyltransferase and the 53Bp1 Tumour Suppressor' FitzGerald, J,Moureau, S,Drogaris, P,O'Connell, E,Abshiru, N,Verreault, A,Thibault, P,Grenon, M,Lowndes, NF (2011) 'Regulation of the DNA Damage Response and Gene Expression by the Dot1L Histone Methyltransferase and the 53Bp1 Tumour Suppressor'. Plos One, 6 [DOI] [Details]
	(2010)	'Chromatin assembly and signalling the end of DNA repair requires acetylation of histone H3 on lysine 56' Costelloe, T, Lowndes, NF (2010) 'Chromatin assembly and signalling the end of DNA repair requires acetylation of histone H3 on lysine 56'. Sub-cellular Biochemistry, 50 :43-54 [Details]
	(2010)	'M. Dynamics of Rad9 chromatin binding and checkpoint function are mediated by its dimerization and are cell cycle-regulated by CDK1 activity' • Granata M, Lazzaro F, Novarina D, Panigada D, Puddu F, Abreu CM, Kumar R, Grenon M, Lowndes NF, Plevani P, Muzi-Falconi M. (2010) 'M. Dynamics of Rad9 chromatin binding and checkpoint function are mediated by its dimerization and are cell cycle-regulated by CDK1 activity'. Plos Genetics, 6 (8) [Details]
	(2010)	'Chromatin assembly and signalling the end of DNA repair requires acetylation of histone H3 on lysine 56' Costelloe T, Lowndes NF (2010) 'Chromatin assembly and signalling the end of DNA repair requires acetylation of histone H3 on lysine 56'. Biochem, 50 :43-54 [DOI] [Details]
	(2010)	'The interplay between BRCA1 and 53BP1 influences death, aging, senescence and cancer' Lowndes, NF (2010) 'The interplay between BRCA1 and 53BP1 influences death, aging, senescence and cancer'. Dna Repair, 9 :1112-1116 [DOI] [Details]
	(2010)	'MRN and the race to the break' Rupnik A, Lowndes NF, Grenon M (2010) 'MRN and the race to the break'. Chromosoma, 119 (2):115-135 [DOI] [Details]
	(2010)	'Chromatin Assembly and Signalling the End of DNA Repair Requires Acetylation of Histone H3 on Lysine 56' Costelloe, T,Lowndes, NF,Nasheuer, HP (2010) 'Chromatin Assembly and Signalling the End of DNA Repair Requires Acetylation of Histone H3 on Lysine 56'. Genome Stability And Human Diseases, 50 :43-54 [DOI] [Details]
	(2009)	'Genetic Evidence for Single-Strand Lesions Initiating Nbs1-Dependent Homologous Recombination in Diversification of Ig V in Chicken B Lymphocytes' Nakahara, M,Sonoda, E,Nojima, K,Sale, JE,Takenaka, K,Kikuchi, K,Taniguchi, Y,Nakamura, K,Sumitomo, Y,Bree, RT,Lowndes, NF,Takeda, S (2009) 'Genetic Evidence for Single-Strand Lesions Initiating Nbs1-Dependent Homologous Recombination in Diversification of Ig V in Chicken B Lymphocytes'. Plos Genetics, 5 [DOI] [Details]
	(2009)	'Enhanced Protein Detection Using a Trapping Mode on a Hybrid Quadrupole Linear Ion Trap (Q-Trap)' Drogaris, P,Le Blanc, JCY,Fitzgerald, JE,Lowndes, NF,Verreault, A,Thibault, P (2009) 'Enhanced Protein Detection Using a Trapping Mode on a Hybrid Quadrupole Linear Ion Trap (Q-Trap)'. Analytical Chemistry, 81 :6300-6309 [DOI] [Details]
	(2009)	'53BP1: function and mechanisms of focal recruitment' FitzGerald JE, Grenon M, Lowndes NF (2009) '53BP1: function and mechanisms of focal recruitment'. Biochemical Society Transactions, 37 (Pt 4):897-904 [DOI] [Details]
	(2008)	'Quick Guide: The MRN complex' Rupnik A, Grenon M, Lowndes NF (2008) 'Quick Guide: The MRN complex'. Curr Biol, 18 (11):455-457 [Details]
	(2008)	'The MRN complex' Rupnik A, Grenon M, Lowndes N (2008) 'The MRN complex'. Current Biology, 18 (11):1-7 [DOI] [Details]
	(2007)	'Transcriptional response of Candida parapsilosis following exposure to farnesol' Rossignol, T,Logue, ME,Reynolds, K,Grenon, M,Lowndes, NF,Butler, G (2007) 'Transcriptional response of Candida parapsilosis following exposure to farnesol'. Antimicrobial Agents And Chemotherapy, 51 :2304-2312 [DOI] [Details]
	(2007)	'Comparisons between DT40 wildtype and DT40-Cre1 cells as suitable model systems for studying the DNA damage response' Bree RT, Lai XY, Canavan LE, Lowndes NF (2007) 'Comparisons between DT40 wildtype and DT40-Cre1 cells as suitable model systems for studying the DNA damage response'. Cell Cycle, 6 (18):2310-2313 [Details]
	(2007)	'An investigation into 53BP1 complex formation' Roche KC, Lowndes NF (2007) 'An investigation into 53BP1 complex formation'. Advances In Tnf Family Research, 604 :47-57 [DOI] [Details]
	(2007)	'Mobility and distribution of replication protein A in living cells using fluorescence correlation spectroscopy' Braet, C,Stephan, H,Dobbie, IM,Togashi, DM,Ryder, AG,Foldes-Papp, Z,Lowndes, N,Nasheuer, HP (2007) 'Mobility and distribution of replication protein A in living cells using fluorescence correlation spectroscopy'. Experimental And Molecular Pathology, 82 :156-162 [DOI] [Details]
	(2007)	'Docking onto chromatin via the Saccharomyces cerevisiae Rad9 Tudor domain' Grenon, M,Costelloe, T,Jimeno, S,O'Shaughnessy, A,FitzGerald, J,Zgheib, O,Degerth, L,Lowndes, NF (2007) 'Docking onto chromatin via the Saccharomyces cerevisiae Rad9 Tudor domain'. Yeast, 24 :105-119 [DOI] [Details]
	(2007)	'An investigation into 53BP1 complex formation' Roche KC and Lowndes NF (2007) 'An investigation into 53BP1 complex formation'. Adv Exp Med Biol, 604 :47-57 [Details]
	(2007)	'Chaperoning the Cln3 cyclin prevents promiscuous activation of start' Lowndes NF (2007) 'Chaperoning the Cln3 cyclin prevents promiscuous activation of start'. Molecular Cell, 27 (1):1-2 [DOI] [Details]
	(2006)	'Genetic dissection of vertebrate 53BP1: A major role in non-homologous end joining of DNA double strand breaks' Nakamura, K,Sakai, W,Kawamoto, T,Bree, RT,Lowndes, NF,Takeda, S,Taniguchi, Y (2006) 'Genetic dissection of vertebrate 53BP1: A major role in non-homologous end joining of DNA double strand breaks'. Dna Repair, 5 :741-749 [DOI] [Details]
	(2006)	'Multiple approaches to study Scerevisiae Rad9, a prototypical checkpoint protein' O'Shaughnessy AM, Grenon M, Gilbert C, Toh GW-L, Green CM and Lowndes NF (2006) 'Multiple approaches to study Scerevisiae Rad9, a prototypical checkpoint protein'. Meths Enzym, 409 :131-150 [Details]
	(2006)	'Chromatin modulation and the DNA damage response' Costelloe T, Fitzgerald J, Murphy NJ, Flaus A, Lowndes NF (2006) 'Chromatin modulation and the DNA damage response'. Experimental Cell Research, 312 (14):2677-2686 [DOI] [Details]
	(2006)	'DNA repair: from molecular mechanism to human disease' Friedberg EC, Aguilera A, Gellert M, Hanawalt PC, Hays JB, Lehmann AR, Lindahl T, Lowndes N, Sarasin A, Wood RD. (2006) 'DNA repair: from molecular mechanism to human disease'. DNA Repair Amst, 5 [Details]
	(2006)	'Double-strand breaks trigger MRX- and Mec1-dependent, but Tel1-independent, checkpoint activation' Grenon, M,Magill, CP,Lowndes, NF,Jackson, SP (2006) 'Double-strand breaks trigger MRX- and Mec1-dependent, but Tel1-independent, checkpoint activation'. Fems Yeast Research, 6 :836-847 [DOI] [Details]
	(2005)	'DNA repair: the importance of phosphorylating histone H2AX' Lowndes NF, Toh GW (2005) 'DNA repair: the importance of phosphorylating histone H2AX'. Current Biology, 15 (3):1-1 [DOI] [Details]
	(2004)	'DNA Damage Surveillance in Saccharomyces cerevisiae' Toh GW-L and Lowndes NF. (2004) 'DNA Damage Surveillance in Saccharomyces cerevisiae'. Eukaryotic DNA Damage Surveillance and Repair, [Details]
	(2004)	'Remodelling the Rad9 checkpoint complex - Preparing Rad53 for action' van den Bosch, M,Lowndes, NF (2004) 'Remodelling the Rad9 checkpoint complex - Preparing Rad53 for action'. Cell Cycle, 3 :119-122 [Details]
	(2004)	'The switch from survival responses to apoptosis after chromosomal breaks' Bree RT, Neary C, Samali A, Lowndes NF (2004) 'The switch from survival responses to apoptosis after chromosomal breaks'. Dna Repair, 3 (8-9):989-995 [DOI] [Details]
	(2004)	'Purification and analysis of checkpoint protein complexes from Saccharomyces cerevisiae' Green CM, Lowndes NF (2004) 'Purification and analysis of checkpoint protein complexes from Saccharomyces cerevisiae'. Methods Mol Biol, 280 :291-306 [DOI] [Details]
	(2003)	'The MRN complex: coordinating and mediating the response to broken chromosomes' van den Bosch M, Bree RT, Lowndes NF (2003) 'The MRN complex: coordinating and mediating the response to broken chromosomes'. Embo Reports, 4 (9):844-849 [DOI] [Details]
	(2003)	'Yeast histone 2A serine 129 is essential for the efficient repair of checkpoint-blind DNA damage' Redon, C,Pilch, DR,Rogakou, EP,Orr, AH,Lowndes, NF,Bonner, WM (2003) 'Yeast histone 2A serine 129 is essential for the efficient repair of checkpoint-blind DNA damage'. Embo Reports, 4 :678-684 [DOI] [Details]
	(2003)	'The budding yeast Rad9 checkpoint complex: chaperone proteins are required for its function' Gilbert, CS,van den Bosch, M,Green, CM,Vialard, JE,Grenon, M,Erdjument-Bromage, H,Tempst, P,Lowndes, NF (2003) 'The budding yeast Rad9 checkpoint complex: chaperone proteins are required for its function'. Embo Reports, 4 :953-958 [DOI] [Details]
	(2003)	'Role of the Saccharomyces cerevisiae Rad9 protein in sensing and responding to DNA damage' Toh GW, Lowndes NF (2003) 'Role of the Saccharomyces cerevisiae Rad9 protein in sensing and responding to DNA damage'. Biochemical Society Transactions, 31 (Pt 1):242-246 [DOI] [Details]
	(2003)	'Remodelling the Rad9 checkpoint complex' van den Bosch M and Lowndes NF. (2003) 'Remodelling the Rad9 checkpoint complex'. Cell Cycle, 3 :1-4 [Details]
	(2002)	'Budding yeast as a eukaryotic model for understanding the mechanisms of cellular responses to DNA damage' de la Torre-Ruiz MA, Toh GW-L and Lowndes, NF. (2002) 'Budding yeast as a eukaryotic model for understanding the mechanisms of cellular responses to DNA damage'. Recent Research Developments in DNA repair and Mutagenesis Research Signpost, India, :67-80 [Details]
	(2001)	'Checkpoint activation in response to double-strand breaks requires the Mre11/Rad50/Xrs2 complex' Grenon, M,Gilbert, C,Lowndes, NF (2001) 'Checkpoint activation in response to double-strand breaks requires the Mre11/Rad50/Xrs2 complex'. Nature Cell Biology, 3 :844-847 [Details]
	(2001)	'Budding yeast Rad9 is an ATP-dependent Rad53 activating machine' Gilbert, CS,Green, CM,Lowndes, NF (2001) 'Budding yeast Rad9 is an ATP-dependent Rad53 activating machine'. Molecular Cell, 8 :129-136 [Details]
	(2001)	'Inducible nucleotide excision repair of UV induced cyclobutane pyrimidine dimers in the Saccharomyces cerevisiae MFA2 gene' Yu S, Teng Y, Lowndes NF and Waters R. (2001) 'Inducible nucleotide excision repair of UV induced cyclobutane pyrimidine dimers in the Saccharomyces cerevisiae MFA2 gene'. Mutat Res, 485 :229-236 [Details]
	(2001)	'Topoisomerase III acts upstream of Rad53p in the S-phase DNA damage checkpoint' Chakraverty RK, Kearsey JM, Oakley TJ, Grenon M, de La Torre Ruiz MA, Lowndes NF, Hickson ID (2001) 'Topoisomerase III acts upstream of Rad53p in the S-phase DNA damage checkpoint'. Molecular And Cellular Biology, 21 (21):7150-7162 [DOI] [Details]
	(2001)	'RAD9, RAD24, RAD16 and RAD26 are required for the inducible nucleotide excision repair of UV-induced cyclobutane pyrimidine dimers from the transcribed and non-transcribed regions of the Saccharomyces cerevisiae MFA2 gene' Yu S, Teng Y, Lowndes NF, Waters R (2001) 'RAD9, RAD24, RAD16 and RAD26 are required for the inducible nucleotide excision repair of UV-induced cyclobutane pyrimidine dimers from the transcribed and non-transcribed regions of the Saccharomyces cerevisiae MFA2 gene'. Mutation Research, 485 (3):229-236 [Details]
	(2001)	'DNA-damage signaling and apoptosis' Lowndes NF (2001) 'DNA-damage signaling and apoptosis'. Genome, 2 (11) [Details]
	(2000)	'DUN1 defines one branch downstream of RAD53 for transcription and DNA damage repair in Saccharomyces cerevisiae' de la Torre Ruiz MA, Lowndes NF (2000) 'DUN1 defines one branch downstream of RAD53 for transcription and DNA damage repair in Saccharomyces cerevisiae'. Febs Letters, 485 (2-3):205-206 [Details]
	(2000)	'A role for Saccharomyces cerevisiae histone H2A in DNA repair' Downs JA, Lowndes NF, Jackson SP (2000) 'A role for Saccharomyces cerevisiae histone H2A in DNA repair'. Nature, 408 (6815):1001-1004 [DOI] [Details]
	(2000)	'Sensing and responding to DNA damage' Lowndes NF, Murguia JR (2000) 'Sensing and responding to DNA damage'. Gene, 10 (1):17-25 [Details]
	(2000)	'The Saccharomyces cerevisiae DNA damage checkpoint is required for efficient repair of double strand breaks by non-homologous end joining' de la Torre-Ruiz M, Lowndes NF (2000) 'The Saccharomyces cerevisiae DNA damage checkpoint is required for efficient repair of double strand breaks by non-homologous end joining'. Febs Letters, 467 (2-3):311-315 [Details]
	(2000)	'Sensing and responding to DNA damage' Lowndes NF and Murguia, JR. (2000) 'Sensing and responding to DNA damage'. Curr Opin Genet & Dev, 10 :17-25 [Details]
	(2000)	'A novel Rad24 checkpoint protein complex closely related to replication factor C' Green CM, Erdjument-Bromage H, Tempst P, Lowndes NF (2000) 'A novel Rad24 checkpoint protein complex closely related to replication factor C'. Current Biology, 10 (1):39-42 [Details]
	(2000)	'The S cerevisiae DNA damage checkpoint is required for efficient repair of double strand breaks by non-homologous end joining' de la Torre-Ruiz MA and Lowndes NF. (2000) 'The S cerevisiae DNA damage checkpoint is required for efficient repair of double strand breaks by non-homologous end joining'. FEBS Letts, 467 :311-315 [Details]
	(1999)	'DNA damage-dependent checkpoints in yeasts and human cells' Lowndes NF. (1999) 'DNA damage-dependent checkpoints in yeasts and human cells'. Eur J Cancer, 35 :1573-1574 [Details]
	(1999)	'The BRCT domain of the S. cerevisiae checkpoint protein Rad9 mediates a Rad9-Rad9 interaction after DNA damage' Soulier J, Lowndes NF (1999) 'The BRCT domain of the S. cerevisiae checkpoint protein Rad9 mediates a Rad9-Rad9 interaction after DNA damage'. Current Biology, 9 (10):551-554 [Details]
	(1998)	'RAD9 and RAD24 define two additive, interacting branches of the DNA damage checkpoint pathway in budding yeast normally required for Rad53 modification and activation' de la Torre-Ruiz MA, Green CM, Lowndes NF (1998) 'RAD9 and RAD24 define two additive, interacting branches of the DNA damage checkpoint pathway in budding yeast normally required for Rad53 modification and activation'. Embo Journal, 17 (9):2687-2698 [DOI] [Details]
	(1998)	'Human and mouse homologs of Schizosaccharomyces pombe rad1(+) and Saccharomyces cerevisiae RAD17: linkage to checkpoint control and mammalian meiosis' Freire R, MurguÃa JR, Tarsounas M, Lowndes NF, Moens PB, Jackson SP (1998) 'Human and mouse homologs of Schizosaccharomyces pombe rad1(+) and Saccharomyces cerevisiae RAD17: linkage to checkpoint control and mammalian meiosis'. Gene, 12 (16):2560-2573 [Details]
	(1998)	'The budding yeast Rad9 checkpoint protein is subjected to Mec1/Tel1-dependent hyperphosphorylation and interacts with Rad53 after DNA damage' Vialard JE, Gilbert CS, Green CM, Lowndes NF (1998) 'The budding yeast Rad9 checkpoint protein is subjected to Mec1/Tel1-dependent hyperphosphorylation and interacts with Rad53 after DNA damage'. Embo Journal, 17 (19):5679-5688 [DOI] [Details]
	(1998)	'c-Ha-ras bidirectional promoter expressed in vitro: location and regulation' (1998) 'c-Ha-ras bidirectional promoter expressed in vitro: location and regulation'. Mol Cell Biol, 9 :3758-3770 [Details]
	(1998)	'Human and mouse homologues of S pombe rad1+ and S cerevisiae RAD17: linkage to checkpoint control and mammalian meiosis' Freire R, Murguia JR, Tarsounas M, Lowndes NF, Moens PB and Jackson, SP. (1998) 'Human and mouse homologues of S pombe rad1+ and S cerevisiae RAD17: linkage to checkpoint control and mammalian meiosis'. Genes & Dev, 12 :2560-2573 [Details]
	(1996)	'The RAD9 checkpoint gene of Saccharomyces cerevisiae controls a DNA damage-specific transcriptional response' Aboussekhra A., Vialard JE, Morrison DE, de la Torre-Ruiz MA, Cernakova, L., Fabre, F and Lowndes, NF (1996) 'The RAD9 checkpoint gene of Saccharomyces cerevisiae controls a DNA damage-specific transcriptional response'. EMBO J, 15 :3912-3922 [Details]
	(1996)	'A novel role for the budding yeast RAD9 checkpoint gene in DNA damage-dependent transcription' Aboussekhra A, Vialard JE, Morrison DE, de la Torre-Ruiz MA, CernÃ¡kovÃ¡ L, Fabre F, Lowndes NF (1996) 'A novel role for the budding yeast RAD9 checkpoint gene in DNA damage-dependent transcription'. Embo Journal, 15 (15):3912-3922 [Details]
	(1992)	'Cell cycle control of DNA synthesis in budding yeast' Johnston LH and Lowndes NF. (1992) 'Cell cycle control of DNA synthesis in budding yeast'. Nucleic Acids Res, 20 (10):2403-2410 [Details]
	(1992)	'SWI6 protein is required for transcription of the periodically expressed DNA synthesis genes in budding yeast' Lowndes NF, Johnson AL, Breeden L, Johnston LH (1992) 'SWI6 protein is required for transcription of the periodically expressed DNA synthesis genes in budding yeast'. Nature, 357 (6378):505-508 [DOI] [Details]
	(1992)	'Parallel pathways of cell cycle-regulated gene expression' Lowndes, N.F. and Johnston, L.H. (1992) 'Parallel pathways of cell cycle-regulated gene expression'. Trends Genet, 8 :79-81 [Details]
	(1992)	'Control of DNA synthesis genes in fission yeast by the cell-cycle gene cdc10+' Lowndes NF, McInerny CJ, Johnson AL, Fantes PA, Johnston LH (1992) 'Control of DNA synthesis genes in fission yeast by the cell-cycle gene cdc10+'. Nature, 355 (6359):449-453 [DOI] [Details]
	(1992)	'Parallel pathways of cell cycle-regulated gene expression' Lowndes NF, Johnston LH (1992) 'Parallel pathways of cell cycle-regulated gene expression'. Gene, 8 (3):79-81 [Details]
	(1992)	'DNA synthesis control in yeast: an evolutionarily conserved mechanism for regulating DNA synthesis genes?' Merrill GF, Morgan BA, Lowndes NF, Johnston LH (1992) 'DNA synthesis control in yeast: an evolutionarily conserved mechanism for regulating DNA synthesis genes?'. Bioessays, 14 (12):823-830 [DOI] [Details]
	(1992)	'Periodic transcription during the late G1 phase of the budding yeast cell cycle' Merrill G, Morgan B, Lowndes NF and Johnston LH (1992) 'Periodic transcription during the late G1 phase of the budding yeast cell cycle'. BioEssays, 14 :823-830 [Details]
	(1991)	'The yeast DNA ligase gene CDC9 is controlled by six orientation specific upstream activating sequences that respond to cellular proliferation but which alone cannot mediate cell cycle regulation' White JH, Johnson AL, Lowndes NF, Johnston LH (1991) 'The yeast DNA ligase gene CDC9 is controlled by six orientation specific upstream activating sequences that respond to cellular proliferation but which alone cannot mediate cell cycle regulation'. Nucleic Acids Research, 19 (2):359-364 [Details]
	(1991)	'A cell-cycle-regulated trans-factor, DSC1, controls expression of DNA synthesis genes in yeast' Johnston LH, Lowndes NF, Johnson AL, Sugino A (1991) 'A cell-cycle-regulated trans-factor, DSC1, controls expression of DNA synthesis genes in yeast'. Cold Spring Harb Symp Quant Biol, 56 :169-176 [Details]
	(1991)	'Coordination of expression of DNA synthesis genes in budding yeast by a cell-cycle regulated trans factor' Lowndes NF, Johnson AL, Johnston LH (1991) 'Coordination of expression of DNA synthesis genes in budding yeast by a cell-cycle regulated trans factor'. Nature, 350 (6315):247-250 [DOI] [Details]
	(1990)	'A short, highly repetitive element in intron -1 of the human c-Ha-ras gene acts as a block to transcriptional readthrough by a viral promoter' Lowndes NF, Bushel P, Mendelsohn L, Wu J, Yen MY, Allan M (1990) 'A short, highly repetitive element in intron -1 of the human c-Ha-ras gene acts as a block to transcriptional readthrough by a viral promoter'. Molecular And Cellular Biology, 10 (9):4990-4995 [Details]
	(1989)	'c-Ha-ras gene bidirectional promoter expressed in vitro: location and regulation' Lowndes NF, Paul J, Wu J, Allan M (1989) 'c-Ha-ras gene bidirectional promoter expressed in vitro: location and regulation'. Molecular And Cellular Biology, 9 (9):3758-3770 [Details]

Book Chapters

	Year	Publication
	(2008)	'Fluorescent Proteins, in Fluorescent Proteins' Dobie, IM, Lowndes, NF and Sullivan, KF (2008) 'Fluorescent Proteins, in Fluorescent Proteins' In: Methods in Cell Biology. [Details]

Conference Publications

	Year	Publication
	(2009)	*53BP1: function and mechanisms of focal recruitment* FitzGerald, JE,Grenon, M,Lowndes, NF (2009) BIOCHEMICAL SOCIETY TRANSACTIONS 53BP1: function and mechanisms of focal recruitment , pp.897-904 [DOI] [Details]
	(2007)	*An investigation into 53BP1 complex formation* Roche, KC,Lowndes, NF (2007) ADVANCES IN MOLECULAR ONCOLOGY An investigation into 53BP1 complex formation , pp.47-57 [Details]
	(2003)	*Role of the Saccharomyces in sensing and responding cerevisiae Rad9 protein to DNA damage* Toh, GWL,Lowndes, NF (2003) BIOCHEMICAL SOCIETY TRANSACTIONS Role of the Saccharomyces in sensing and responding cerevisiae Rad9 protein to DNA damage , pp.242-246 [Details]

Correction

	Year	Publication
	(2008)	Transcriptional response of Candida parapsilosis following exposure to farnesol (vol 51, pg 2304, 2007). Rossignol, T,Logue, ME,Reynolds, K,Grenon, M,Lowndes, NF,Butler, G (2008) Transcriptional response of Candida parapsilosis following exposure to farnesol (vol 51, pg 2304, 2007). Correction [DOI] [Details]

Editorial

	Year	Publication
	(2008)	The MRN complex. Rupnik, A,Grenon, M,Lowndes, N (2008) The MRN complex. Editorial [Details]
	(2007)	Chaperoning the Cln3 cyclin prevents promiscuous activation of Start. Lowndes, NF (2007) Chaperoning the Cln3 cyclin prevents promiscuous activation of Start. Editorial [DOI] [Details]
	(2006)	DNA repair: From molecular mechanism to human disease. Friedberg, EC,Aguilera, A,Gellert, M,Hanawalt, PC,Hays, JB,Lehmann, AR,Lindahl, T,Lowndes, N,Sarasin, A,Wood, RD (2006) DNA repair: From molecular mechanism to human disease. Editorial [DOI] [Details]
	(2005)	DNA repair: The importance of phosphorylating histone H2AX. Lowndes, NF,Toh, GWL (2005) DNA repair: The importance of phosphorylating histone H2AX. Editorial [DOI] [Details]

Letter

	Year	Publication
	(2007)	Comparisons between DT40 wildtype and DT40-Cre1 cells as suitable model systems for studying the DNA damage response. Bree, RT,Lai, XY,Canavan, LE,Lowndes, NF (2007) Comparisons between DT40 wildtype and DT40-Cre1 cells as suitable model systems for studying the DNA damage response. Letter [Details]

Meeting

	Year	Publication
	(2013)	HYPDXIA ENHANCES THE RADIO-RESISTANCE OF MOUSE MESENCHYMAL STROMAL CELLS. Sugrue, T,Ceredig, R,Lowndes, N (2013) HYPDXIA ENHANCES THE RADIO-RESISTANCE OF MOUSE MESENCHYMAL STROMAL CELLS. Meeting [Details]

Reviews

	Year	Publication
	(2013)	Mesenchymal stromal cells: radio-resistant members of the bone marrow. Sugrue, T,Lowndes, NF,Ceredig, R (2013) Mesenchymal stromal cells: radio-resistant members of the bone marrow. Reviews [DOI] [Details]
	(2012)	Eukaryotic DNA damage checkpoint activation in response to double-strand breaks. Finn, K,Lowndes, NF,Grenon, M (2012) Eukaryotic DNA damage checkpoint activation in response to double-strand breaks. Reviews [DOI] [Details]
	(2010)	MRN and the race to the break. Rupnik, A,Lowndes, NF,Grenon, M (2010) MRN and the race to the break. Reviews [DOI] [Details]
	(2009)	53BP1: Function and Mechanisms of Focal Recruitment. Biochemistry Society Transactions. FitzGerald J, Grenon M, Lowndes NF (2009) 53BP1: Function and Mechanisms of Focal Recruitment. Biochemistry Society Transactions. Reviews [Details]
	(2008)	Autofluorescent proteins. Dobbie, IM,Lowndes, NF,Sullivan, KF (2008) Autofluorescent proteins. Reviews [DOI] [Details]
	(2006)	Chromatin modulation and the DNA damage response. Costelloe, T,FitzGerald, J,Murphy, NJ,Flaus, A,Lowndes, NF (2006) Chromatin modulation and the DNA damage response. Reviews [DOI] [Details]
	(2006)	Multiple approaches to study S-cerevisiae Rad9, a prototypical checkpoint protein. O'Shaughnessy, AM,Grenon, M,Gilbert, C,Toh, GWL,Green, CM,Lowndes, NF (2006) Multiple approaches to study S-cerevisiae Rad9, a prototypical checkpoint protein. Reviews [DOI] [Details]
	(2004)	The switch from survival responses to apoptosis after chromosomal breaks. Bree, RT,Neary, C,Samali, A,Lowndes, NF (2004) The switch from survival responses to apoptosis after chromosomal breaks. Reviews [DOI] [Details]
	(2003)	The MRN complex: coordinating and mediating the response to broken chromosomes. van den Bosch, M,Bree, RT,Lowndes, NF (2003) The MRN complex: coordinating and mediating the response to broken chromosomes. Reviews [DOI] [Details]