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Biological and Chemical Sciences

Dr Lynn O'Connor

B.Sc, Ph.D.

 
researcher
 

Biography

Lecturer in Department of Biochemistry NUI, Galway. Jan 2003 to present: Lecturer in St. Angela's College, Lough Gill, Sligo. Oct 1994 - Jan 2003 Visiting Research Fellow, UU Coleraine, Derry Oct 1992 - Oct 1993 Lecturer (permanent position),DCU, Dublin Oct 1985 - Oct 1989 Postdoctoral Research Fellow, TCD, Dublin Oct 1984 - Oct 1985 Postdoctoral Research Fellow, Baylor College of Medicine, Houston, Tx, USA Jan 1982 - Sept 1984 Ph.D (1981) Department of Biochemistry, NUI, Galway.

Research Interests

The control of adipogenesis, influence of steroid hormones and environmental estrogens

Peer Reviewed Journals

  Year Publication
(1980) 'Analysis by IEF of the microsomal proteins of skeletal muscle'
McHale, L & Headon, D.R. (1980) 'Analysis by IEF of the microsomal proteins of skeletal muscle'. J Muscle Res & Cell Motility, 4 :463-446 [Details]
(1988) 'The effects of hematoporphyrin detivative (HPD)and human erythrocyte encapsulated HPD on a mouse myeloma cell line'
A.P.McHale, L. McHale & W.Blau (1988) 'The effects of hematoporphyrin detivative (HPD)and human erythrocyte encapsulated HPD on a mouse myeloma cell line'. Cancer Biochemistry and Biophysics, 10 :157-164 [Details]
(1988) 'Modification of human salivary amylase using dextran T-70'
B.Donlon, McHale, L. (1988) 'Modification of human salivary amylase using dextran T-70'. Biotechnology Letters, 5 :559-562 [Details]
(1988) 'Use of a tetrazolium based colorimetric assay in assessing photoradiation therapy in vitro'
McHale & L.McHale (1988) 'Use of a tetrazolium based colorimetric assay in assessing photoradiation therapy in vitro'. Cancer Letters, 41 :315-321 [Details]
(1989) 'A specific zymogram staining procedure for exocellobiohydrolase components produced by T emersonii'
A.P.McHale, T.J. Hackett & L. McHale (1989) 'A specific zymogram staining procedure for exocellobiohydrolase components produced by T emersonii'. Enzyme and Microbial Technology, 11 :17-20 [Details]
(1989) 'Production, isolation and partial characterisation of an alpha-amylase produced by T emersonii L'
Bunni, L. McHale & A.P.McHale (1989) 'Production, isolation and partial characterisation of an alpha-amylase produced by T emersonii L'. Enzyme and Microbial Technology, 11 :370-375 [Details]
(1989) 'Use of piezoelectric shock waves to effect release of amylase from capsules containing the amylase producing rat pancreatic tumour cell line AR42J'
B.Jones, U.McCarthy, L.Bunni, L.McHale, B.Butler, J. Seary & A.P.McHale (1989) 'Use of piezoelectric shock waves to effect release of amylase from capsules containing the amylase producing rat pancreatic tumour cell line AR42J'. Biotechnology Techniques, 3 :355-360 [Details]
(1992) 'cDNA cloning and expression of a T emersonii amylase encoding genetic determinant in E coli'
L.Bunni, D.C.Coleman, L.McHale, T.J. Hackett & A.P.McHale (1992) 'cDNA cloning and expression of a T emersonii amylase encoding genetic determinant in E coli'. Biotechnology Letters, 14 :1009-1114 [Details]
(1993) 'The tumoricidal potential of extracorporeal shock-wave therapy'
D.McCormack, B.J.Jones, J.McElwain, L.McHale & A.P.McHale (1993) 'The tumoricidal potential of extracorporeal shock-wave therapy'. European Journal of Surgical Oncology, 19 :232-234 [Details]
(1993) 'Studies on the growth of a thermotolerant yeast strain, Kluyvermyces marxianus IMB3, on sucrose containng media'
M.Fleming, N.Barron, L.McHale, R.Marchant & A.P.McHale (1993) 'Studies on the growth of a thermotolerant yeast strain, Kluyvermyces marxianus IMB3, on sucrose containng media'. Biotechnology Letters, 15 :1195-1198 [Details]
(1993) 'Molecular cloning and functional expression of a T emersonii derived alpha- Amylase encoding genetic determinant in a human cell line'
L.Bunni, T.J.Hackett, L.McHale, & A.P. McHale (1993) 'Molecular cloning and functional expression of a T emersonii derived alpha- Amylase encoding genetic determinant in a human cell line'. Biotechnology Letters, 15 :1095-1100 [Details]
(1993) 'Production of cellulae and beta-glucosidase activities following growth of Streptomyces hygroscopicus on cellulose containing media'
L.Spear, J.Gallagher, L.McHale & A.P.McHale (1993) 'Production of cellulae and beta-glucosidase activities following growth of Streptomyces hygroscopicus on cellulose containing media'. Biotechnology Letters, 15 :1265-1268 [Details]
(1994) 'Ethanol production at 45oC by an alginate-immobilised thermotolerant strain of Kluyveromyces marxianus following growth on glucose-containing media'
A.M.Nolan, N.Barron, D.Brady, T.McAree, D.Smith, L.McHale, A.P.McHale (1994) 'Ethanol production at 45oC by an alginate-immobilised thermotolerant strain of Kluyveromyces marxianus following growth on glucose-containing media'. Biotechnology Letters, 16 :849-852 [Details]
(1994) 'Magnetically responsive photosensitising reagents for possible use in photo- Radiation therapy'
G.Flynn, T.J.Hackett, L.McHale & A.P.McHale (1994) 'Magnetically responsive photosensitising reagents for possible use in photo- Radiation therapy'. Cancer Letters, 78 :109-114 [Details]
(1994) 'Microbial biosorption of metals: Potential in the treatment of metal pollution'
A,P,McHale & L McHale (Eds: M.Moo-Young, B.R. Glick, Y. Christi, C.R. Barnett, J.S..G.Dooley, A.P.McHale & P.G.McKenna (1994) 'Microbial biosorption of metals: Potential in the treatment of metal pollution'. Biotechnology Advances: Special Issue: Biotechnology and Industry: Present and Future, :647-652 [Details]
(1994) 'Production of ethanol by the thermotolerant yeast kluyveromyces marxianus IMB3 during growth on lactose-containing media'
D.Brady, R.Marchant, L.McHale & A.P.McHale (1994) 'Production of ethanol by the thermotolerant yeast kluyveromyces marxianus IMB3 during growth on lactose-containing media'. Biotechnology Letters, 16 :737-740 [Details]
(1994) 'Methotrexate-loaded, photosensitized erythrocytes: A photo-activatable carrier/ delivery system for use in cancer therapy'
G.Flynn, L.McHale & A.P. McHale (1994) 'Methotrexate-loaded, photosensitized erythrocytes: A photo-activatable carrier/ delivery system for use in cancer therapy'. Cancer Letters, 82 :225-229 [Details]
(1994) 'Growth of a thermotolerant, ethanol-producing strain of Kluyveromyces Marxianus IMB3 during growth on lactose-containing media'
N.Barron, R.Marchant, L.McHale& A.P.McHale (1994) 'Growth of a thermotolerant, ethanol-producing strain of Kluyveromyces Marxianus IMB3 during growth on lactose-containing media'. Biotechnology Letters, 16 :625-630 [Details]
(1994) 'Encapsulation of the thrombolytic enzyme, brinase, in photosensitised erythrocytes: a novel thrombolytic system based upon photodynamic therapy'
G.Flynn, T.J.Hackett, L.McHale & A.P.McHale (1994) 'Encapsulation of the thrombolytic enzyme, brinase, in photosensitised erythrocytes: a novel thrombolytic system based upon photodynamic therapy'. Journal of Photochemistry and Photobiology, 26 :193-196 [Details]
(1995) 'Partial characterization of -glucosidase activity produced by Kluyveromyces marxianus IMB3 during growth on cellulose-containing media at 45oC N'
Barron, R.Marchant, L.McHale & A.P.McHale (1995) 'Partial characterization of -glucosidase activity produced by Kluyveromyces marxianus IMB3 during growth on cellulose-containing media at 45oC N'. Biotechnology Letters, 17 :1047-1050 [Details]
(1995) 'Studies on the use of a thermotolerant strain of Kluyveromyces marxianus in simultaneous saccharification and fermentation of cellulose to ethanol'
N.Barron, R.Marchant, L.McHale & A.P.McHale (1995) 'Studies on the use of a thermotolerant strain of Kluyveromyces marxianus in simultaneous saccharification and fermentation of cellulose to ethanol'. Applied Microbiologyand Biotechnology, 43 :518-520 [Details]
(1995) 'Partial characterization of -galactosidase activity produced by a thermotolerant strain of Kluyveromyces marxianus IMB3 during growth on lactose-containing media'
D.Brady, R.Marchant, L.McHale & A.P.McHale (1995) 'Partial characterization of -galactosidase activity produced by a thermotolerant strain of Kluyveromyces marxianus IMB3 during growth on lactose-containing media'. Enzyme and Microbial Technolology, 17 :696-699 [Details]
(1995) 'The effects of phosphoric acid pretreatment on conversion of cellulose to ethanol at 45oC using the thermotolerant yeast Kluyveromyces marxianus IMB3'
U.Nilsson, N.Barron, L.McHale & A.P.McHale (1995) 'The effects of phosphoric acid pretreatment on conversion of cellulose to ethanol at 45oC using the thermotolerant yeast Kluyveromyces marxianus IMB3'. Biotechnology Letters, 17 :985-988 [Details]
(1995) 'Studies on the biosorption of uranium by Talaromyces emersonii CBS 814 70'
L.Bergstrom, B.Jogansson, L.McHale, R.Marchant & A.P.McHale (1995) 'Studies on the biosorption of uranium by Talaromyces emersonii CBS 814 70'. Applied Microbiology and Biotechnology, 42 :807-811 [Details]
(1995) 'Increased ethanol production during growth of electric-field stimulated Kluyveromyces marxianus IMB3 during growth on lactose-containing media'
J.Simpson, D.Brady, A.Rollan, N.Barron, L.McHale &A.P.McHale (1995) 'Increased ethanol production during growth of electric-field stimulated Kluyveromyces marxianus IMB3 during growth on lactose-containing media'. Biotechnology Letters, 17 :757-760 [Details]
(1995) 'The effect of electric field stimulation on the biosorption of uranium by non- living biomass derived from Kluyveromyces marxianus IMB3 N'
Donnellan, A.Rollan, L.McHale & A.P.McHale (1995) 'The effect of electric field stimulation on the biosorption of uranium by non- living biomass derived from Kluyveromyces marxianus IMB3 N'. Biotechnology Letters, 17 :439-442 [Details]
(1995) 'Increased efficiency of substrate utilization by exposure of the thermotolerant yeast strain, Kluyveromyces marxianus IMB3 to electric field stimulation'
A.McCabe, N.Barron, L.McHale & A.P.McHale (1995) 'Increased efficiency of substrate utilization by exposure of the thermotolerant yeast strain, Kluyveromyces marxianus IMB3 to electric field stimulation'. Biotechnology Techniques, 9 :133-136 [Details]
(1995) 'The effects of Mn2 on ethanol production by Kluyveromyces marxianus IMB3 during growth on lactose containing media at 45C'
D.Brady, R.Marchant, L.McHale & A.P.McHale (1995) 'The effects of Mn2 on ethanol production by Kluyveromyces marxianus IMB3 during growth on lactose containing media at 45C'. Biotechnology Letters, 17 :233-236 [Details]
(1995) 'Production of ethanol at 45oC on starch-containing media by mixed cultures of the thermotolerant, ethanol-producing yeast Kluyveromyces marxianus IMB3 and the thermophilicfilamentous fungus Talaromyces emersonii CBS 814 70'
C.Ward, A.M.Nolan, K.O'Hanlon, T.McAree, N.Barron, L.McHale & A.P.McHale. (1995) 'Production of ethanol at 45oC on starch-containing media by mixed cultures of the thermotolerant, ethanol-producing yeast Kluyveromyces marxianus IMB3 and the thermophilicfilamentous fungus Talaromyces emersonii CBS 814 70'. Applied Microbiology and Biotechnology, 43 :408-411 [Details]
(1996) 'The effect of pulse field strength on electric field stimulated biosorptin of uranium by Kluyveromyces marxianus IMB3'
M.Bustard, N.Donnellan, A.Rollan, L.McHale & A.P.McHale (1996) 'The effect of pulse field strength on electric field stimulated biosorptin of uranium by Kluyveromyces marxianus IMB3'. Biotechnology Letters, 18 :479-482 [Details]
(1996) 'Ethanol production from cellulose at 45oC using a batch-fed system containing alginate- immobilized Kluyveromyces marxianus IMB3'
N.Barron, R.Marchant, L.McHale & A.P.McHale (1996) 'Ethanol production from cellulose at 45oC using a batch-fed system containing alginate- immobilized Kluyveromyces marxianus IMB3'. World Journal of Microbiology and Biotechnology, 12 :103-104 [Details]
(1996) 'Use of real-time confocal laser scanning microscopy to study immediate effects of photodynamic activation on photosensitized erythrocytes'
A.Rollan, T.Ward, G.Flynn, G.McKerr, L.McHale & A.P.McHale (1996) 'Use of real-time confocal laser scanning microscopy to study immediate effects of photodynamic activation on photosensitized erythrocytes'. Cancer Letters, 101 :165-169 [Details]
(1996) 'Production of cellulase and -glucosidase activity during growth of the actinomycete Micromonospora chalcae on cellulose-containing media'
J.Gallagher, A.Winters, N.Barron, L.McHale & A.P.McHale (1996) 'Production of cellulase and -glucosidase activity during growth of the actinomycete Micromonospora chalcae on cellulose-containing media'. Bi Biotechnology Letters, 18 :537-540 [Details]
(1996) 'Production of ethanol from sucrose at 45oC by alginate-immobilized preparations of the thermotolerant yeast strain Kluyveromyces marxianus IMB3'
C.Riordan, D.Brady, N.Barron, M.Fleming, R.Marchant, L.McHale & A.P.McHale (1996) 'Production of ethanol from sucrose at 45oC by alginate-immobilized preparations of the thermotolerant yeast strain Kluyveromyces marxianus IMB3'. Bioresource Technology, 55 :171-173 [Details]
(1996) 'Magnetically responsive alginate-based biocatalysts: Applications in Space Biotechnology'
D. Brady, L. McHale & A.P. McHale (1996) 'Magnetically responsive alginate-based biocatalysts: Applications in Space Biotechnology'. Life Sciences Research in Space: European Space Agency Publication SP 390, :339-344 [Details]
(1996) 'Ethanol production at 45oC by Kluyveromyces marxianus IMB3 immobilized in magnetically responsive alginate matrices'
D. Brady, P. Nigam, L. McHale & A.P. McHale (1996) 'Ethanol production at 45oC by Kluyveromyces marxianus IMB3 immobilized in magnetically responsive alginate matrices'. Biotechnology Letters, 18 :1213-1216 [Details]
(1996) 'The effects of electric fields on photosensitized erythrocytes: Possible enhancement of photodynamic activation'
T. Ward, A. Rollan, N. Barron, L. McHale & A.P. McHale (1996) 'The effects of electric fields on photosensitized erythrocytes: Possible enhancement of photodynamic activation'. Cancer Letters, 106 :69-74 [Details]
(1996) 'A rapid in situ colorimetric assay for the determinatino of mammalian cell variability in alginate-immobilized and encapsulated systems'
A.Rollan, D.McCormack, H.McCormack, L.McHale & A.P.McHale (1996) 'A rapid in situ colorimetric assay for the determinatino of mammalian cell variability in alginate-immobilized and encapsulated systems'. Bioprocess Engineering, 15 :47-49 [Details]
(1996) 'Alginate-immobilized thermotolerant yeast for conversion of cellulose to ethanol'
N.Barron, D.Brady, G.Love, R.Marchant, L.McHale & A.P.McHale (1996) 'Alginate-immobilized thermotolerant yeast for conversion of cellulose to ethanol'. Progress in Biotechnology 11 Immobilized Cells: Basics and Applications, 11 [Details]