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Biological and Chemical Sciences

Dr Eddie Myers

BA., MSc., PhD

Contact Details

Lecturer Above The Bar
School of Chemistry
University of Galway
E: eddie.myers@universityofgalway.ie
 
researcher
 

Biography


  2017 - Present: Lecturer in Organic Chemistry, NUI Galway
  2014 - 2017: Research Officer, University of Bristol, Lab of V. Aggarwal
  2012 - 2014: Associate Editor, Chemistry-A European Journal, Wiley-VCH 
  2012 - 2012: Assistant Editor, Angewandte Chemie, Wiley-VCH
  2010 - 2012: LMU Research Fellow, LMU-Munich, Germany, Lab of D. Trauner             
  2006 - 2009: Postdoctoral Associate, University of Wisconsin–Madison, Lab of R. Raines 
  2002 - 2006: Ph.D., University of Bristol (2006), Lab. of V. Aggarwal
  2002 - 2002: M.Sc.  McGill University (2003), Lab of Y. Tsantrizos
  1996 - 2000: B.A. Natural Science, Trinity College Dublin (2000), First Class, Gold Medal

Research Interests

Research in the Myers group lies at the interface between chemistry and biology. Current activities can be assigned to one or both of two themes: a) chemical biology of the extracellular matrix (ECM); b) novel methods for carbon-nitrogen bond formation.
  
Chemical Biology of the Extracellular Matrix (ECM)
Our goal is to elucidate in great detail the mechanism of formation of advanced glycation endproducts (AGEs), specifically crosslinks derived from ternary reactions of glucose, lysine and arginine. We are also interested in exploring the biological implications of our findings, particularly the role AGEs in diabetes, and potential avenues for therapeutic interventions. In the area of regenerative medicine, we are interested in developing small-molecule building blocks and reagents for generating collagen-and elastin-like materials with desirable mechanical and biochemical properties. 

Novel Methods for Carbon-Nitrogen Bond Formation
We are interested in the design and development of main-group catalysts for the condensation of small-molecule carboxylic acids and amines. To support activities in our chemical biology theme, we are developing bioorthogonal reagents and methods for forming amide bonds involving large biomolecules. We are also exploring conceptually new ways of transforming azides. 

Group Website: http://www.eddiemyerschemistry.com/

Peer Reviewed Journals

  Year Publication
(2023) 'Conformationally Controlled sp3-Hydrocarbon-Based α-Helix Mimetics'
Dewis, Lydia I. and Rudrakshula, Madhavachary and Williams, Christopher and Chiarparin, Elisabetta and Myers, Eddie L. and Butts, Craig P. and Aggarwal, Varinder K. (2023) 'Conformationally Controlled sp3-Hydrocarbon-Based α-Helix Mimetics'. Angewandte Chemie International Edition, 62 (23) [DOI] [Details]
(2022) 'Iterative synthesis of 1,3-polyboronic esters with high stereocontrol and application to the synthesis of bahamaolide A'
Aiken, Sheenagh G. and Bateman, Joseph M. and Liao, Hsuan-Hung and Fawcett, Alexander and Bootwicha, Teerawut and Vincetti, Paolo and Myers, Eddie L. and Noble, Adam and Aggarwal, Varinder K. (2022) 'Iterative synthesis of 1,3-polyboronic esters with high stereocontrol and application to the synthesis of bahamaolide A'. Nature Chemistry, 15 (2) [DOI] [Details]
(2021) 'Conformationally Controlled Linear and Helical Hydrocarbons Bearing Extended Side Chains'
Lin Guo and Oliver J. Dutton and Murat Kucukdisli and Matthew Davy and Olivier Wagni\`eres and Craig P. Butts and Eddie L. Myers and Varinder K. Aggarwal (2021) 'Conformationally Controlled Linear and Helical Hydrocarbons Bearing Extended Side Chains'. Journal of the American Chemical Society, [DOI] [Details]
(2020) 'Odd\textendasheven alternations in helical propensity of a homologous series of hydrocarbons'
Johan A. Pradeilles and Siying Zhong and M\'arton Baglyas and György Tarczay and Craig P. Butts and Eddie L. Myers and Varinder K. Aggarwal (2020) 'Odd\textendasheven alternations in helical propensity of a homologous series of hydrocarbons'. Nature Chemistry, 12 (5):475-480 [DOI] [Details]
(2019) 'Ring-Opening Lithiation\textendashBorylation of 2-Trifluoromethyl Oxirane: A Route to Versatile Tertiary Trifluoromethyl Boronic Esters'
Meganathan Nandakumar and Bel\'en Rubial and Adam Noble and Eddie L. Myers and Varinder K. Aggarwal (2019) 'Ring-Opening Lithiation\textendashBorylation of 2-Trifluoromethyl Oxirane: A Route to Versatile Tertiary Trifluoromethyl Boronic Esters'. Angewandte Chemie International Edition, 59 (3):1187-1191 [DOI] [Details]
(2019) 'Ring-Opening Lithiation\textendashBorylation of 2-Trifluoromethyl Oxirane: A Route to Versatile Tertiary Trifluoromethyl Boronic Esters'
Meganathan Nandakumar and Bel\'en Rubial and Adam Noble and Eddie L. Myers and Varinder K. Aggarwal (2019) 'Ring-Opening Lithiation\textendashBorylation of 2-Trifluoromethyl Oxirane: A Route to Versatile Tertiary Trifluoromethyl Boronic Esters'. Angewandte Chemie, 132 (3):1203-1207 [DOI] [Details]
(2018) 'Enantiodivergent Synthesis of Allenes by Point-to-Axial Chirality Transfer'
Roly J. Armstrong and Meganathan Nandakumar and Rafael M. P. Dias and Adam Noble and Eddie L. Myers and Varinder K. Aggarwal (2018) 'Enantiodivergent Synthesis of Allenes by Point-to-Axial Chirality Transfer'. Angewandte Chemie, 130 (27):8335-8340 [DOI] [Details]
(2017) 'Selective uni- and bidirectional homologation of diborylmethane'
Blair, Daniel J.,Tanini, Damiano,Bateman, Joseph M.,Scott, Helen K.,Myers, Eddie L.,Aggarwal, Varinder K. (2017) 'Selective uni- and bidirectional homologation of diborylmethane'. Chemical Science, 8 (4):2898-2903 [DOI] [Details]
(2017) 'Stereodivergent Olefination of Enantioenriched Boronic Esters'
Armstrong, Roly J.,Garcia-Ruiz, Cristina,Myers, Eddie L.,Aggarwal, Varinder K. (2017) 'Stereodivergent Olefination of Enantioenriched Boronic Esters'. Angewandte Chemie - International Edition, 56 (3):786-790 [DOI] [Details]
(2017) 'Iterative assembly line synthesis of polypropionates with full stereocontrol'
Bootwicha, Teerawut,Feilner, Julian M.,Myers, Eddie L.,Aggarwal, Varinder K. (2017) 'Iterative assembly line synthesis of polypropionates with full stereocontrol'. Nature Chemistry, 9 (9):896-902 [DOI] [Details]
(2017) 'Enantioselective Rhodium(III)-Catalyzed Markovnikov Hydroboration of Unactivated Terminal Alkenes'
Smith, James R.,Collins, Beatrice S. L.,Hesse, Matthew J.,Graham, Mark A.,Myers, Eddie L.,Aggarwal, Varinder K. (2017) 'Enantioselective Rhodium(III)-Catalyzed Markovnikov Hydroboration of Unactivated Terminal Alkenes'. Journal Of The American Chemical Society, 139 (27):9148-9151 [DOI] [Details]
(2017) 'Enantiospecific synthesis of ortho-substituted benzylic boronic esters by a 1,2-metalate rearrangement/1,3-borotropic shift sequence'
Aichhorn, Stefan,Bigler, Raphael,Myers, Eddie L.,Aggarwal, Varinder K. (2017) 'Enantiospecific synthesis of ortho-substituted benzylic boronic esters by a 1,2-metalate rearrangement/1,3-borotropic shift sequence'. Journal Of The American Chemical Society, 139 (28):9519-9522 [DOI] [Details]
(2017) 'Photoinduced decarboxylative borylation of carboxylic acids'
Fawcett, Alexander,Pradeilles, Johan,Wang, Yahui,Mutsuga, Tatsuya,Myers, Eddie L.,Aggarwal, Varinder K. (2017) 'Photoinduced decarboxylative borylation of carboxylic acids'. Science (Washington, DC, United States), 357 (6348):283-286 [Details]
(2017) 'Synergy of synthesis, computation and NMR reveals correct baulamycin structures'
Wu, Jingjing,Lorenzo, Paula,Zhong, Siying,Ali, Muhammad,Butts, Craig P.,Myers, Eddie L.,Aggarwal, Varinder K. (2017) 'Synergy of synthesis, computation and NMR reveals correct baulamycin structures'. Nature, 547 (7664):436-440 [DOI] [Details]
(2017) 'Asymmetric Synthesis of Secondary and Tertiary Boronic Esters'
Collins, Beatrice S. L.,Wilson, Claire M.,Myers, Eddie L.,Aggarwal, Varinder K. (2017) 'Asymmetric Synthesis of Secondary and Tertiary Boronic Esters'. Angewandte Chemie - International Edition, 56 (39):11700-11733 [DOI] [Details]
(2017) 'alpha-Sulfinyl Benzoates as Precursors to Li and Mg Carbenoids for the Stereoselective Iterative Homologation of Boronic Esters'
Casoni, Giorgia,Kucukdisli, Murat,Fordham, James M.,Burns, Matthew,Myers, Eddie L.,Aggarwal, Varinder K. (2017) 'alpha-Sulfinyl Benzoates as Precursors to Li and Mg Carbenoids for the Stereoselective Iterative Homologation of Boronic Esters'. Journal Of The American Chemical Society, 139 (34):11877-11886 [DOI] [Details]
(2017) 'The Story behind Synergy of Synthesis, Computation, and NMR Reveals Correct Baulamycin Structures'
Lorenzo, Paula,Butts, Craig P.,Myers, Eddie L.,Aggarwal, Varinder K. (2017) 'The Story behind Synergy of Synthesis, Computation, and NMR Reveals Correct Baulamycin Structures'. Biochemistry, [DOI] [Details]
(2017) 'Enantioselective Rhodium(III)-Catalyzed Markovnikov Hydroboration of Unactivated Terminal Alkenes'
James R. Smith and Beatrice S. L. Collins and Matthew J. Hesse and Mark A. Graham and Eddie L. Myers and Varinder K. Aggarwal (2017) 'Enantioselective Rhodium(III)-Catalyzed Markovnikov Hydroboration of Unactivated Terminal Alkenes'. Journal of the American Chemical Society, 139 (27):9148-9151 [DOI] [Details]
(2016) 'Enantiospecific Alkynylation of Alkylboronic Esters'
Wang, Yahui,Noble, Adam,Myers, Eddie L.,Aggarwal, Varinder K. (2016) 'Enantiospecific Alkynylation of Alkylboronic Esters'. Angewandte Chemie - International Edition, 55 (13):4270-4274 [DOI] [Details]
(2016) 'Regio- and Stereoselective Homologation of 1,2-Bis(Boronic Esters): Stereocontrolled Synthesis of 1,3-Diols and Sch 725674'
Fawcett, Alexander,Nitsch, Dominik,Ali, Muhammad,Bateman, Joseph M.,Myers, Eddie L.,Aggarwal, Varinder K. (2016) 'Regio- and Stereoselective Homologation of 1,2-Bis(Boronic Esters): Stereocontrolled Synthesis of 1,3-Diols and Sch 725674'. Angewandte Chemie - International Edition, 55 (47):14663-14667 [DOI] [Details]
(2016) 'Synthesis of 3-Aryl-1-aminopropane Derivatives: Lithiation-Borylation-Ring-Opening of Azetidinium Ions'
Casoni, Giorgia,Myers, Eddie L.,Aggarwal, Varinder K. (2016) 'Synthesis of 3-Aryl-1-aminopropane Derivatives: Lithiation-Borylation-Ring-Opening of Azetidinium Ions'. Synthesis, 48 (19):3241-3253 [DOI] [Details]
(2014) 'Total Synthesis of the Proposed Structure of Trichodermatide A'
Myers, Eddie,Herrero-Gomez, Elena,Albrecht, Irina,Lachs, Jennifer,Mayer, Peter,Hanni, Matti,Ochsenfeld, Christian,Trauner, Dirk. (2014) 'Total Synthesis of the Proposed Structure of Trichodermatide A'. Journal Of Organic Chemistry, 79 (20):9812-9817 [DOI] [Details]
(2009) 'A phosphine-mediated conversion of azides into diazo compounds'
Myers, Eddie L.,Raines, Ronald T. (2009) 'A phosphine-mediated conversion of azides into diazo compounds'. Angewandte Chemie - International Edition, 48 (13):2359-2363 [DOI] [Details]
(2007) 'A new manifold for the Morita reaction: Diene synthesis from simple aldehydes and acrylates/acrylonitrile mediated by phosphines'
Palmelund, Anders,Myers, Eddie L.,Tai, Lik Ren,Tisserand, Steve,Butts, Craig P.,Aggarwal, Varinder K. (2007) 'A new manifold for the Morita reaction: Diene synthesis from simple aldehydes and acrylates/acrylonitrile mediated by phosphines'. Chemical Communications, (40):4128-4130 [DOI] [Details]
(2007) 'Reactions of iminium ions with Michael acceptors through a Morita-Baylis-Hillman-type reaction: enantiocontrol and applications in synthesis'
Myers, Eddie L.,de Vries, Johannes G.,Aggarwal, Varinder K. (2007) 'Reactions of iminium ions with Michael acceptors through a Morita-Baylis-Hillman-type reaction: enantiocontrol and applications in synthesis'. Angewandte Chemie-International Edition, 46 (11):1893-1896 [DOI] [Details]
(2007) 'Chalcogenides as Organocatalysts'
McGarrigle, Eoghan M.,Myers, Eddie L.,Illa, Ona,Shaw, Michael A.,Riches, Samantha L.,Aggarwal, Varinder K. (2007) 'Chalcogenides as Organocatalysts'. Chemical Reviews, 107 (12):5841-5883 [DOI] [Details]
(2006) 'BF3·OEt2 and TMSOTf: A synergistic combination of Lewis acids'
Myers, Eddie L.,Butts, Craig P.,Aggarwal, Varinder K. (2006) 'BF3·OEt2 and TMSOTf: A synergistic combination of Lewis acids'. Chemical Communications, (42):4434-4436 [DOI] [Details]
(2004) 'Synthesis of novel analogs of aromatic peptide nucleic acids (APNAs) with modified conformational and electrostatic properties'
Fader, Lee D.,Myers, Eddie L.,Tsantrizos, Youla S. (2004) 'Synthesis of novel analogs of aromatic peptide nucleic acids (APNAs) with modified conformational and electrostatic properties'. Tetrahedron, 60 (10):2235-2246 [DOI] [Details]

Book Chapters

  Year Publication
(2022) 'Bicyclic 5:6 Systems: Other Four Heteroatoms 2:2'
Myers, EL (2022) 'Bicyclic 5:6 Systems: Other Four Heteroatoms 2:2' In: Comprehensive Heterocyclic Chemistry IV. Amsterdam: Elsevier. [Details]
(2012) 'Selected diastereoselective reactions: electrocyclizations'
Myers, E. L.,Trauner, D. (2012) 'Selected diastereoselective reactions: electrocyclizations' In: Compr. Chirality. :563-606 Amsterdam: Elsevier B.V. [Details]

Honours and Awards

  Year Title Awarding Body
2009 Alexander von Humboldt Fellowship (declined) Alexander von Humboldt Foundation
2009 LMU Research Fellowship LMU-Munich
2003 Dean's Honor List McGill University
2002 T. Sterry Hunt Award for Excellence in Teaching McGill University
2001 Alexander McFee Fellowship McGill University
2000 Graduate Award Institute of Chemistry of Ireland
2000 Cocker Prize and Medal Trinity College Dublin
2000 John Winthorp Hackett Moderatorship Prize Trinity College Dublin
2000 Gold Medal Trinity College Dublin
1999 Dr. George A. Lonergan Prize Trinity College Dublin
1998 Elected Scholar of Trinity College Trinity College Dublin
1998 D.C. Pepper Prize Trinity College Dublin
1997 Eli Lilly Chemistry Prize Trinity College Dublin
1997 Henley Memorial Prize Trinity College Dublin

Professional Associations

  Association Function From / To
Royal Society of Chemistry Member /
European Peptide Society Member /

Employment

  Employer Position From / To
University of Bristol Research Officer 01-OCT-14 / 31-AUG-17
Wiley-VCH Associate Editor 01-SEP-12 / 30-SEP-14
Wiley-VCH Assistant Editor 01-FEB-12 / 31-AUG-12
LMU Munich LMU Fellow 15-DEC-09 / 31-DEC-11
University of Wisconsin-Madison Postdoctoral Associate 01-OCT-06 / 30-NOV-09

Education

  Year Institution Qualification Subject
2006 University of Bristol PhD Organic Chemistry
2003 McGill University MASTERS OF SCIENCE Organic Chemistry
2000 Trinity College Dublin Bachelor of Arts Natural Science/Chemistry

Recent Postgraduate Students

  Graduation Name Degree Primary Supervisor
2023 Guillermo Palop PhD Y
2019 Damian Jablonski MASTERS OF SCIENCE Y
2020 Lee-Ann Keane PhD Y

Current Postgraduate Students (Research)

  Student Degree Type Type
Roisin Leen Doctorate - Structured PhD (Science) Supervisor
Abdulmoez Elkhbuli Doctorate - Structured PhD (Science) Supervisor
Matthew Murray Doctorate - Structured PhD (Science) Supervisor
Ardra Karthika Doctorate - Structured PhD (Science) Supervisor
Grace Sutton Doctorate - Structured PhD (Science) Co-supervisor (1)
Ciaran Mc Grory Masters - Research - Master of Science Supervisor

Modules Taught

  Term/Year Module Title Module Code Subject / Desc
Semester II/2024 Introduction to Medicinal Chemistry CH2101
Semester II/2024 Computers and Chemical Research CH3101 Technical Writing and Report Writing
Semester II/2024 Organic Chemistry CH202
Semester II/2024 Current Topics in Medicinal Chemistry CH4114
Semester I/2023 Practical Skills Development CH451
Semester I/2023 Organic Chemistry CH311
Semester I/2023 Experimental Chemistry I CH333
Semester I/2023 Independent Research Investigation CH4101
Semester II/2024 Organic Chemistry CH4113 Pericyclic and Radical Reactions

External Collaborators

  Name Organisation / Institute Country Description of Collaboration
Varinder Aggarwal University of Bristol UNITED KINGDOM