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Biological and Chemical Sciences

Prof Ciaran Morrison

BSc, MSc, Dr.Rer.Nat,,Nat.Cert

 
researcher
 

Biography

Web: http://www.chromosome.ie/researchers/morrison/
Researcher ID: B-6568-2008/ ORCID: 0000-0003-2401-7029
                         
Professor Ciaran Morrison obtained a B.Sc. in Biochemistry at the University of Galway, then undertook an M.Sc. by Research in Microbiology under the supervision of Prof. Frank Gannon, also at Galway.  He was then selected for the international Ph.D. Programme of the Institute for Molecular Pathology in Vienna, graduating ‘mit Auszeichnung’ from the University of Vienna in 1997.  Prof. Morrison was awarded a Foreign Postdoctoral Fellowship by the Japan Society for the Promotion of Science to undertake postdoctoral research in Kyoto University with Prof. Shunichi Takeda.  He was then awarded a European Molecular Biology Organisation Longterm Postdoctoral Fellowship for postdoctoral research with Prof. Bill Earnshaw at the University of Edinburgh.  In October 2002, Prof. Morrison returned to the University of Galway to set up his own group with an Investigator award from Science Foundation Ireland.  He became a Senior Lecturer in 2005 and received a Personal Professorship in 2011.  To date, he has received 3 Investigator awards from SFI.  Prof. Morrison’'s major research focus is on the cellular mechanisms that allow accurate cell division and prevent damage of the genetic material, a theme that is of particular relevance in cancer biology.  He has published more than 50 research papers and has a current h-index of 34.  Prof. Morrison has supervised 18 Ph.D. students to successful completion of their Theses. From 2014-2016, he was academic lead on the SFI-funded International Strategic Cooperation Award with Japan.  He was Head of the School of Natural Sciences from February 1, 2017 until January 31, 2021. Professor Morrison was a Visiting Professor at the University of Geneva in the Guichard/ Hamel lab from October, 2021-March, 2022.

Research Interests

Overview:  Centrosome abnormalities and amplification are common characteristics of tumour cells. Aneuploidy and chromosomal instability are highly correlated with the appearance of multiple centrosomes. Supernumerary centrosomes can cause mitotic abnormalities, such as the formation of multipolar spindles, potentially giving rise to abnormal chromosome segregation.

Normally, centrosome amplification is tightly regulated during the cell cycle. Previous work from our group has demonstrated that DNA damage leads to centrosome amplification. One goal of our work is to understand how DNA damage is signalled to the centrosome duplication apparatus and to define the impact this has on proliferating cells. We want to understand whether centrosome amplification is a physiologically-relevant trigger of programmed cell death through indefinite arrest or mitotic catastrophe, or a potential contributor to genomic instability and tumourigenesis.

We also explore how specific components of the centrosome regulate DNA repair and cell cycle checkpoint activities. Several key proteins of the centriole and the pericentriolar material are directly involved in control of the cell cycle, before and after DNA damage and we want to establish how they carry out the different functions that they have been assigned. We are using cell biology and reverse genetics to explore these questions.
                                                 
Keywords:  DNA double-strand break repair, cell cycle, genome stability. Centrosomes. Analysis of mitotic effects of DNA damage (microscopy and proteomic approaches). Reverse genetics using tissue culture lines.

Peer Reviewed Journals

  Year Publication
(2022) 'The CP110-CEP97-CEP290 module orchestrates a centriolar satellite dependent response to proteotoxic stress'
Prosser, S.L., Tkach, J., Gheiratmand, L., Kim, J., Raught, B., Morrison, C.G., Pelletier, L. (2022) 'The CP110-CEP97-CEP290 module orchestrates a centriolar satellite dependent response to proteotoxic stress'. Nature Cell Biology, 24 :483-496 [DOI] [Details]
(2022) 'The connecting cilium inner scaffold provides a structural foundation that protects against retinal degeneration'
Mercey, O., Kostic, C., Bertiaux, E., Giroud, A., Sadian, Y., Gaboriau, D., Morrison, C.G., Chang, N., Arsenijevic, Y., Guichard, P., Hamel, V. (2022) 'The connecting cilium inner scaffold provides a structural foundation that protects against retinal degeneration'. Plos Biology, 20 [DOI] [Details]
(2022) 'Redox regulation of RAD51 Cys319 and homologous recombination by peroxiredoxin 1'
Skoko, J.J., Cao, J., Gaboriau, D., Attar, M., Asan, A., Hong, L., Paulsen, C.E., Ma, H., Liu, Y., Wu, H., Harkness, T., Furdui, C.M., Manevich Y., Morrison, C.G., Brown, E.T., Normolle, D., Spies, M., Spies, M.A., Carroll, K., Neumann, C.A. (2022) 'Redox regulation of RAD51 Cys319 and homologous recombination by peroxiredoxin 1'. Redox Biology, 56 [Details]
(2022) 'Human SFI1 and Centrin form a complex critical for centriole architecture and ciliogenesis'
Laporte MH, Bouhlel IB, Bertiaux E, Morrison CG, Giroud A, Borgers S, Azimzadeh J, Bornens M, Guichard P, Paoletti A, Hamel V (2022) 'Human SFI1 and Centrin form a complex critical for centriole architecture and ciliogenesis'. Embo Journal, 41 [DOI] [Details]
(2021) 'Melanin Distribution in Human Skin: Influence of Cytoskeletal, Polarity, and Centrosome-Related Machinery of Stratum basale Keratinocytes'
Castellano-Pellicena I;Morrison CG;Bell M;O'Connor C;Tobin DJ; (2021) 'Melanin Distribution in Human Skin: Influence of Cytoskeletal, Polarity, and Centrosome-Related Machinery of Stratum basale Keratinocytes'. International Journal Of Molecular Sciences, 22 (6) [DOI] [Details]
(2020) 'Altered gene regulation as a candidate mechanism by which ciliopathy gene SDCCAG8 contributes to schizophrenia and cognitive function'
Flynn, M,Whitton, L,Donohoe, G,Morrison, CG,Morris, D (2020) 'Altered gene regulation as a candidate mechanism by which ciliopathy gene SDCCAG8 contributes to schizophrenia and cognitive function'. Human Molecular Genetics, 29 :407-417 [DOI] [ARAN Link] [Details]
(2019) 'Differential requirements for the EF-hand domains of human centrin 2 in primary ciliogenesis and nucleotide excision repair'
Khouj EM;Prosser SL;Tada H;Chong WM;Liao JC;Sugasawa K;Morrison CG; (2019) 'Differential requirements for the EF-hand domains of human centrin 2 in primary ciliogenesis and nucleotide excision repair'. Journal Of Cell Science, 132 (19) [DOI] [Details]
(2018) 'Centrobin controls primary ciliogenesis in vertebrates'
Ogungbenro, YA,Tena, TC,Gaboriau, D,Lalor, P,Dockery, P,Philipp, M,Morrison, CG (2018) 'Centrobin controls primary ciliogenesis in vertebrates'. Journal Of Cell Biology, 217 :1205-1215 [DOI] [Details]
(2017) 'Centriole splitting caused by loss of the centrosomal linker protein C-NAP1 reduces centriolar satellite density and impedes centrosome amplification'
Flanagan, AM,Stavenschi, E,Basavaraju, S,Gaboriau, D,Hoey, DA,Morrison, CG (2017) 'Centriole splitting caused by loss of the centrosomal linker protein C-NAP1 reduces centriolar satellite density and impedes centrosome amplification'. Molecular Biology Of The Cell, 28 :736-745 [DOI] [Details]
(2016) 'Opposing effects of pericentrin and microcephalin on the pericentriolar material regulate CHK1 activation in the DNA damage response'
Antonczak, AK,Mullee, LI,Wang, Y,Comartin, D,Inoue, T,Pelletier, L,Morrison, CG (2016) 'Opposing effects of pericentrin and microcephalin on the pericentriolar material regulate CHK1 activation in the DNA damage response'. Oncogene, 35 :2003-2010 [DOI] [Details]
(2016) 'Proteomics Analysis with a Nano Random Forest Approach Reveals Novel Functional Interactions Regulated by SMC Complexes on Mitotic Chromosomes'
Ohta, S,Montano-Gutierrez, LF,Alves, FD,Ogawa, H,Toramoto, I,Sato, N,Morrison, CG,Takeda, S,Hudson, DF,Rappsilber, J,Earnshaw, WC (2016) 'Proteomics Analysis with a Nano Random Forest Approach Reveals Novel Functional Interactions Regulated by SMC Complexes on Mitotic Chromosomes'. Molecular & Cellular Proteomics, 15 :2802-2818 [DOI] [Details]
(2016) 'CEP164-null cells generated by genome editing show a ciliation defect with intact DNA repair capacity'
Daly, OM,Gaboriau, D,Karakaya, K,King, S,Dantas, TJ,Lalor, P,Dockery, P,Kramer, A,Morrison, CG (2016) 'CEP164-null cells generated by genome editing show a ciliation defect with intact DNA repair capacity'. Journal Of Cell Science, 129 :1769-1774 [DOI] [Details]
(2015) 'Protein stability versus function: effects of destabilizing missense mutations on BRCA1 DNA repair activity'
Gaboriau, DCA,Rowling, PJE,Morrison, CG,Itzhaki, LS (2015) 'Protein stability versus function: effects of destabilizing missense mutations on BRCA1 DNA repair activity'. Biochemical Journal, 466 :613-624 [DOI] [Details]
(2015) 'Centrin2 regulates CP110 removal in primary cilium formation'
Prosser SL, Morrison CG (2015) 'Centrin2 regulates CP110 removal in primary cilium formation'. Journal Of Cell Biology, 208 (6):693-701 [DOI] [Details]
(2015) 'Nek5 promotes centrosome integrity in interphase and loss of centrosome cohesion in mitosis'
Prosser, SL,Sahota, NK,Pelletier, L,Morrison, CG,Fry, AM (2015) 'Nek5 promotes centrosome integrity in interphase and loss of centrosome cohesion in mitosis'. Journal Of Cell Biology, 209 :339-348 [DOI] [Details]
(2014) 'Ciliary abnormalities in senescent human fibroblasts impair proliferative capacity'
Breslin, L,Prosser, SL,Cuffe, S,Morrison, CG (2014) 'Ciliary abnormalities in senescent human fibroblasts impair proliferative capacity'. Cell Cycle, 13 :2773-2779 [DOI] [Details]
(2014) 'Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells'
Flach, J,Bakker, ST,Mohrin, M,Conroy, PC,Pietras, EM,Reynaud, D,Alvarez, S,Diolaiti, ME,Ugarte, F,Forsberg, EC,Le Beau, MM,Stohr, BA,Mendez, J,Morrison, CG,Passegue, E (2014) 'Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells'. Nature, 512 [DOI] [Details]
(2014) 'BOOSTER: Development of a Toolbox for Triage of Large Groups of Individuals Exposed to Radioactive Material'
Schoepff, V,Almasi, I,Amgarou, K,Becker, F,Carrel, F,Carvajal, F,Gaboriau, DC,Gmar, M,Kelemen, A,Kovacs, A,Kovacs-Szeles, E,Lemaire, H,Menaa, N,Mesterhazy, D,Morat, L,Morrison, CG,Perez-Llopis, I,Raskob, W,Robbe, MF,Szabo, S,Testard, I,Trybushnyi, D,Ugolin, N,Viau, M,Vincze, A (2014) 'BOOSTER: Development of a Toolbox for Triage of Large Groups of Individuals Exposed to Radioactive Material'. IEEE Transactions On Nuclear Science, 61 :2210-2216 [DOI] [Details]
(2013) 'Loss of centrioles causes chromosomal instability in vertebrate somatic cells'
Sir, JH,Putz, M,Daly, O,Morrison, CG,Dunning, M,Kilmartin, JV,Gergely, F (2013) 'Loss of centrioles causes chromosomal instability in vertebrate somatic cells'. Journal Of Cell Biology, 203 :747-756 [DOI] [Details]
(2013) 'Abnormal centrosomal structure and duplication in Cep135-deficient vertebrate cells'
Inanc, B,Putz, M,Lalor, P,Dockery, P,Kuriyama, R,Gergely, F,Morrison, CG (2013) 'Abnormal centrosomal structure and duplication in Cep135-deficient vertebrate cells'. Molecular Biology Of The Cell, 24 :2645-2654 [DOI] [Details]
(2013) 'Calcium-Binding Capacity of Centrin2 Is Required for Linear POC5 Assembly but Not for Nucleotide Excision Repair'
Dantas, TJ,Daly, OM,Conroy, PC,Tomas, M,Wang, YF,Lalor, P,Dockery, P,Ferrando-May, E,Morrison, CG (2013) 'Calcium-Binding Capacity of Centrin2 Is Required for Linear POC5 Assembly but Not for Nucleotide Excision Repair'. Plos One, 8 [DOI] [Details]
(2013) 'Promoter hijack reveals pericentrin functions in mitosis and the DNA damage response'
Wang Y, Dantas TJ, Lalor P, Dockery P, Morrison CG (2013) 'Promoter hijack reveals pericentrin functions in mitosis and the DNA damage response'. Cell Cycle, 12 (4):635-646 [DOI] [Details]
(2012) 'SUMO ligase activity of vertebrate Mms21/Nse2 is required for efficient DNA repair but not for Smc5/6 complex stability'
Kliszczak M, Stephan AK, Flanagan AM, Morrison CG (2012) 'SUMO ligase activity of vertebrate Mms21/Nse2 is required for efficient DNA repair but not for Smc5/6 complex stability'. Dna Repair, 11 (10):799-810 [DOI] [Details]
(2012) 'Oscillation of APC/C activity during cell cycle arrest promotes centrosome amplification'
Prosser, SL,Samant, MD,Baxter, JE,Morrison, CG,Fry, AM (2012) 'Oscillation of APC/C activity during cell cycle arrest promotes centrosome amplification'. Journal Of Cell Science, 125 :5353-5368 [DOI] [Details]
(2012) 'C-NAP1 and rootletin restrain DNA damage-induced centriole splitting and facilitate ciliogenesis'
Conroy, PC,Saladino, C,Dantas, TJ,Lalor, P,Dockery, P,Morrison, CG (2012) 'C-NAP1 and rootletin restrain DNA damage-induced centriole splitting and facilitate ciliogenesis'. Cell Cycle, 11 :3769-3778 [DOI] [Details]
(2011) 'The Nse2/Mms21 SUMO ligase of the Smc5/6 complex in the maintenance of genome stability'
Stephan, AK,Kliszczak, M,Morrison, CG (2011) 'The Nse2/Mms21 SUMO ligase of the Smc5/6 complex in the maintenance of genome stability'. Febs Letters, 585 :2907-2913 [DOI] [Details]
(2011) 'Roles of Vertebrate Smc5 in Sister Chromatid Cohesion and Homologous Recombinational Repair'
Stephan, AK,Kliszczak, M,Dodson, H,Cooley, C,Morrison, CG (2011) 'Roles of Vertebrate Smc5 in Sister Chromatid Cohesion and Homologous Recombinational Repair'. Molecular And Cellular Biology, 31 :1369-1381 [DOI] [Details]
(2011) 'Centrosome Amplification in CHO and DT40 Cells by Inactivation of Cyclin-Dependent Kinases'
Steere, N,Wagner, M,Beishir, S,Smith, E,Breslin, L,Morrison, CG,Hochegger, H,Kuriyama, R (2011) 'Centrosome Amplification in CHO and DT40 Cells by Inactivation of Cyclin-Dependent Kinases'. Cytoskeleton, 68 :446-458 [DOI] [Details]
(2011) 'Defective nucleotide excision repair with normal centrosome structures and functions in the absence of all vertebrate centrins'
Dantas TJ, Wang Y, Lalor P, Dockery P, Morrison CG (2011) 'Defective nucleotide excision repair with normal centrosome structures and functions in the absence of all vertebrate centrins'. Journal Of Cell Biology, 193 (2):307-318 [DOI] [Details]
(2010) 'A Centrosome-autonomous Signal That Involves Centriole Disengagement Permits Centrosome Duplication in G2 Phase after DNA Damage'
Inanc, B;Dodson, H;Morrison, CG (2010) 'A Centrosome-autonomous Signal That Involves Centriole Disengagement Permits Centrosome Duplication in G2 Phase after DNA Damage'. Molecular Biology Of The Cell, 21 :3866-3877 [DOI] [Details]
(2010) 'Hematopoietic Stem Cell Quiescence Promotes Error-Prone DNA Repair and Mutagenesis'
Mohrin, M,Bourke, E,Alexander, D,Warr, MR,Barry-Holson, K,Le Beau, MM,Morrison, CG,Passegue, E (2010) 'Hematopoietic Stem Cell Quiescence Promotes Error-Prone DNA Repair and Mutagenesis'. Cell Stem Cell, 7 :174-185 [DOI] [Details]
(2010) 'MCPH1/BRIT1 limits ionizing radiation-induced centrosome amplification'
Brown, JAL,Bourke, E,Liptrot, C,Dockery, P,Morrison, CG (2010) 'MCPH1/BRIT1 limits ionizing radiation-induced centrosome amplification'. Oncogene, 29 :5537-5544 [DOI] [Details]
(2010) 'DNA damage induces Chk1-dependent threonine-160 phosphorylation and activation of Cdk2'
Bourke, E.,Brown, J. A.,Takeda, S.,Hochegger, H.,Morrison, C. G. (2010) 'DNA damage induces Chk1-dependent threonine-160 phosphorylation and activation of Cdk2'. Oncogene, 29 (44):616-24 [Details]
(2009) 'Increased sister chromatid cohesion and DNA damage response factor localization at an enzyme-induced DNA double-strand break in vertebrate cells'
Dodson, H;Morrison, CG (2009) 'Increased sister chromatid cohesion and DNA damage response factor localization at an enzyme-induced DNA double-strand break in vertebrate cells'. Nucleic Acids Research, 37 :6054-6063 [DOI] [Details]
(2009) 'Trf1 is not required for proliferation or functional telomere maintenance in chicken DT40 cells'
Cooley C, Baird KM, Faure V, Wenner T, Stewart JL, Modino S, Slijepcevic P, Farr CJ, Morrison CG (2009) 'Trf1 is not required for proliferation or functional telomere maintenance in chicken DT40 cells'. Molecular Biology Of The Cell, 20 (10):2563-2571 [DOI] [Details]
(2009) 'Centriole separation in DNA damage-induced centrosome amplification'
Saladino C, Bourke E, Conroy PC, Morrison CG (2009) 'Centriole separation in DNA damage-induced centrosome amplification'. Environmental And Molecular Mutagenesis, 50 (8):725-732 [DOI] [Details]
(2008) 'Deconstructing survivin: comprehensive genetic analysis of survivin function by conditional knockout in a vertebrate cell line'
Yue, Z., Carvalho, A., Xu, Z., Yuan, X., Cardinale, S., Ribeiro, S., Lai, F., Gudmundsdottir, E., Gassmann, R., Morrison, C.G., Ruchaud, S. and Earnshaw, W.C. (2008) 'Deconstructing survivin: comprehensive genetic analysis of survivin function by conditional knockout in a vertebrate cell line'. J. Cell Biol, 183 :279-296 [Details]
(2008) 'Ku70 prevents genome instability resulting from heterozygosity of the telomerase RNA component in a vertebrate tumour line'
Faure, V,Wenner, T,Cooley, C,Bourke, E,Farr, CJ,Takeda, S,Morrison, CG (2008) 'Ku70 prevents genome instability resulting from heterozygosity of the telomerase RNA component in a vertebrate tumour line'. Dna Repair, 7 :713-724 [DOI] [Details]
(2008) 'Distinct BRCT domains in Mcph1/Brit1 mediate ionizing radiation-induced focus formation and centrosomal localization'
Jeffers, LJ,Coull, BJ,Stack, SJ,Morrison, CG (2008) 'Distinct BRCT domains in Mcph1/Brit1 mediate ionizing radiation-induced focus formation and centrosomal localization'. Oncogene, 27 :139-144 [DOI] [Details]
(2007) 'Involvement of centrosome amplification in radiation-induced mitotic catastrophe'
Dodson, H;Wheatley, SP;Morrison, CG (2007) 'Involvement of centrosome amplification in radiation-induced mitotic catastrophe'. Cell Cycle, 6 :364-370 [Details]
(2007) 'DNA damage induces Chk1-dependent centrosome amplification'
Bourke, E,Dodson, H,Merdes, A,Cuffe, L,Zachos, G,Walker, M,Gillespie, D,Morrison, CG (2007) 'DNA damage induces Chk1-dependent centrosome amplification'. Embo Reports, 8 :603-609 [DOI] [Details]
(2006) 'Parp-1 protects homologous recombination from interference by Ku and ligase IV in vertebrate cells'
Hochegger, H,Dejsuphong, D,Fukushima, T,Morrison, C,Sonoda, E,Schreiber, V,Zhao, GY,Saberi, A,Masutani, M,Adachi, N,Koyama, H,de Murcia, G,Takeda, S (2006) 'Parp-1 protects homologous recombination from interference by Ku and ligase IV in vertebrate cells'. Embo Journal, 25 :1305-1314 [DOI] [Details]
(2004) 'Centrosome amplification induced by DNA damage occurs during a prolonged G2 phase and involves ATM'
Dodson, H;Bourke, E;Jeffers, LJ;Vagnarelli, P;Sonoda, E;Takeda, S;Earnshaw, WC;Merdes, A;Morrison, C (2004) 'Centrosome amplification induced by DNA damage occurs during a prolonged G2 phase and involves ATM'. Embo Journal, 23 :3864-3873 [DOI] [Details]
(2004) 'Analysis of Scc1-deficient cells defines a key metaphase role of vertebrate cohesin in linking sister kinetochores'
Vagnarelli, P;Morrison, C;Dodson, H;Sonoda, E;Takeda, S;Earnshaw, WC (2004) 'Analysis of Scc1-deficient cells defines a key metaphase role of vertebrate cohesin in linking sister kinetochores'. Embo Reports, 5 :167-171 [DOI] [Details]
(2004) 'Chromosome damage and progression into and through mitosis in vertebrates'
Morrison, C,Rieder, CL (2004) 'Chromosome damage and progression into and through mitosis in vertebrates'. Dna Repair, 3 :1133-1139 [DOI] [Details]
(2002) 'Proteomic analysis of human metaphase chromosomes reveals topoisomerase II alpha as an Aurora B substrate'
Morrison, C;Henzing, AJ;Jensen, ON;Osheroff, N;Dodson, H;Kandels-Lewis, SE;Adams, RR;Earnshaw, WC (2002) 'Proteomic analysis of human metaphase chromosomes reveals topoisomerase II alpha as an Aurora B substrate'. Nucleic Acids Research, 30 :5318-5327 [Details]
(2001) 'Ku impedes homologous DNA recombination: competition between the major DNA double-strand break repair pathways'
Fukushima, T., Takata, M., Morrison, C., Araki, R., Fujimori A., Abe, M., Tatsumi, K., Jasin, M., Dhar, P.K., Sonoda, E., Chiba, T. and Takeda, S (2001) 'Ku impedes homologous DNA recombination: competition between the major DNA double-strand break repair pathways'. J. biol. Chem, 276 :44413-44418 [Details]
(2001) 'Scc1/ Rad21/ Mcd1 is required for sister chromatid cohesion and kinetochore function in vertebrate cells'
Sonoda, E., Matsusaka, T., Morrison, C., Vagnarelli, P., Hoshi, O.,Ushiki, T., Nojima, K., Fukugawa, T., Waizenegger, I.C., Peters, J.-M., Earnshaw, W.C. and Takeda, S. (2001) 'Scc1/ Rad21/ Mcd1 is required for sister chromatid cohesion and kinetochore function in vertebrate cells'. Dev. Cell, 1 :759-770 [Details]
(2000) 'The controlling role of ATM in homologous recombinational repair of DNA damage'
Morrison, C., Sonoda, E., Takao, N., Shinohara, A., Yamamoto, K. and Takeda, S. (2000) 'The controlling role of ATM in homologous recombinational repair of DNA damage'. EMBO J, 19 :463-471 [Details]
(2000) 'The Rad51 paralog Rad51B promotes homologous recombinational repair'
Takata, M., Sasaki, M.S., Sonoda, E., Fukushima, T., Morrison, C., Albala, J., Swagemakers, S.M.A., Kanaar, R., Thompson, L.H. and Takeda, S. (2000) 'The Rad51 paralog Rad51B promotes homologous recombinational repair'. Mol. Cell. Biol, 20 :6476-6482 [Details]
(1999) 'The essential functions of human Rad51 do not require ATP hydrolysis'
Morrison, C., Shinohara, A., Sonoda, E., Yamaguchi-Iwai, Y., Takata, M., Weichselbaum, R.R. and Takeda, S. (1999) 'The essential functions of human Rad51 do not require ATP hydrolysis'. Mol. Cell. Biol, 19 :6891-6897 [Details]
(1999) 'Mre11 is essential for the maintenance of chromosomal DNA in vertebrate cells'
Yamaguchi-Iwai, Y., Sonoda, E., Sasaki, M.S., Morrison, C., Haraguchi, T., Hiraoka, Y., Yamashita, Y.M., Takata, M., Price, C., Kakazu, N. and Takeda, S. (1999) 'Mre11 is essential for the maintenance of chromosomal DNA in vertebrate cells'. EMBO J, 18 :6619-6629 [Details]
(1999) 'Sister chromatid exchanges are mediated by homologous recombination in vertebrate cells'
Sonoda, E., Sasaki, M.S., Morrison, C., Yamaguchi-Iwai, Y., Takata, M. and Takeda, S. (1999) 'Sister chromatid exchanges are mediated by homologous recombination in vertebrate cells'. Mol. Cell. Biol, 19 :5166-5169 [Details]
(1999) 'Disruption of ATM in p53-null cells causes multiple functional abnormalities in cellular response to ionizing radiation'
Takao, N., Kato, H., Mori, R., Morrison, C., Sonoda, E., Sun, X., Shimizu, H., Yoshioka, K., Takeda, S. and Yamamoto, K. (1999) 'Disruption of ATM in p53-null cells causes multiple functional abnormalities in cellular response to ionizing radiation'. Oncogene, 18 :7002-7009 [Details]
(1998) 'Homologous recombination and nonhomologous end-joining pathways of double-strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells'
Takata, M., Sasaki, M.S., Sonoda, E., Morrison, C., Hashimoto, M., Utsumi, H., Yamaguchi-Iwai, Y., Shinohara, A. and Takeda, S (1998) 'Homologous recombination and nonhomologous end-joining pathways of double-strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells'. EMBO J, 17 :5497-5508 [Details]
(1998) 'Homologous recombination, but not DNA repair, is reduced in vertebrate cells deficient in RAD52'
Yamaguchi-Iwai, Y., Sonoda, E., Buerstedde, J.-M., Bezzubova, O., Morrison, C., Takata, M., Shinohara, A. and Takeda, S. (1998) 'Homologous recombination, but not DNA repair, is reduced in vertebrate cells deficient in RAD52'. Mol. Cell. Biol, 18 :6430-6435 [Details]
(1997) 'Genetic interaction between PARP and DNA-PK in V(D)J recombination and tumorigenesis'
Morrison, C., Smith G.C.M., Stingl, L., Jackson, S.P., Wagner, E.F. and Wang, Z.Q. (1997) 'Genetic interaction between PARP and DNA-PK in V(D)J recombination and tumorigenesis'. Nat. Genet, 17 :479-482 [Details]
(1997) 'PARP is important for genomic stability but dispensable in apoptosis'
Wang, Z.Q., Stingl, L., Morrison, C., Jantsch, M., Los, M., Schulze-Osthoff, K. and Wagner, E.F. (1997) 'PARP is important for genomic stability but dispensable in apoptosis'. Genes Dev, 11 :2347-2358 [Details]
(1996) 'Extrachromosomal recombination occurs efficiently in cells defective in various DNA repair systems'
Morrison, C. and Wagner, E. (1996) 'Extrachromosomal recombination occurs efficiently in cells defective in various DNA repair systems'. Nucleic Acids Res, 24 :2053-2058 [Details]
(1994) 'THE IMPACT OF THE PCR PLATEAU-PHASE ON QUANTITATIVE PCR'
MORRISON, C;GANNON, F (1994) 'THE IMPACT OF THE PCR PLATEAU-PHASE ON QUANTITATIVE PCR'. Biochimica Et Biophysica Acta-Gene Structure And Expression, 1219 :493-498 [Details]

Book Chapters

  Year Publication
(2007) 'DNA Repair in vertebrates'
Morrison, C. (2007) 'DNA Repair in vertebrates' In: Cell Biology. Saunders Philadelphia. [Details]

Conference Publications

  Year Publication
(2013) 2013 3RD INTERNATIONAL CONFERENCE ON ADVANCEMENTS IN NUCLEAR INSTRUMENTATION, MEASUREMENT METHODS AND THEIR APPLICATIONS (ANIMMA)
Schoepff, V;Alamsi, I;Amgarou, K;Becker, F;Carrel, F;Carvajal, F;Gaboriau, DC;Gmar, M;Kovacs, A;Lemaire, H;Menaa, N;Morat, L;Morrison, CG;Perez-Llopis, I;Raskob, W;Szabo, S;Szeles, E;Testard, I;Trybushnyi, D;Ugolin, N;Viau, M;Vincze, A (2013) BOOSTER: Development of a Toolbox for Triage of Large Group of Individuals Exposed to Radioactive Material 2013 3RD INTERNATIONAL CONFERENCE ON ADVANCEMENTS IN NUCLEAR INSTRUMENTATION, MEASUREMENT METHODS AND THEIR APPLICATIONS (ANIMMA) [Details]
(2003) BIOCHEMICAL SOCIETY TRANSACTIONS
Morrison, C;Vagnarelli, P;Sonoda, E;Takeda, S;Earnshaw, WC (2003) Sister chromatid cohesion and genome stability in vertebrate cells BIOCHEMICAL SOCIETY TRANSACTIONS , pp.263-265 [Details]

Conference Contributions

  Year Publication
(2020) BSCB GenSoc meeting UK Cilia Spring e-Meeting 3,
Ciaran Morrison (2020) Oral presentation. [Oral Presentation], BSCB GenSoc meeting UK Cilia Spring e-Meeting 3, Online , 26-MAY-20 - 26-MAY-20. [Details]
(2019) International University of Andalusia (UNIA) meeting 'Molecular causes of primary microcephaly and related diseases',
Ciaran Morrison (2019) Organising committee and speaker. [Conference Organising Committee Member], International University of Andalusia (UNIA) meeting 'Molecular causes of primary microcephaly and related diseases', Baeza, Spain , 18-NOV-19 - 20-NOV-19. [Details]
(2018) Barcelona Biomed Conference ‘Centrosomes, cilia and cell cycle in development and disease‘,
Ciaran Morrison (2018) Selected abstract. [Oral Presentation], Barcelona Biomed Conference ‘Centrosomes, cilia and cell cycle in development and disease‘, Barcelona, Spain , 11-JUN-18 - 13-JUN-18. [Details]
(2017) 10th French GDR meeting on ‘Cilia, Flagella and Centrosomes’,
Ciaran Morrison (2017) Plenary lecture. [Plenary Lecture], 10th French GDR meeting on ‘Cilia, Flagella and Centrosomes’, Nice, France , 10-OCT-17 - 12-OCT-17. [Details]
(2016) Irish Association for Cancer Research annual meeting,
Ciaran Morrison (2016) Plenary lecture. [Plenary Lecture], Irish Association for Cancer Research annual meeting, Cork, Ireland , 25-FEB-16 - 26-FEB-16. [Details]
(2015) Gordon Research Conference on ‘Cell Growth and Proliferation’,
Ciaran Morrison (2015) Selected abstract. [Oral Presentation], Gordon Research Conference on ‘Cell Growth and Proliferation’, Mount Snow, VT, USA , 12-JUL-15 - 16-JUL-15. [Details]
(2014) EMBO Conference on ‘Centrosomes and Spindle Pole Bodies’,
Ciaran Morrison (2014) Selected abstract. [Oral Presentation], EMBO Conference on ‘Centrosomes and Spindle Pole Bodies’, Lisbon, Portugal , 30-SEP-14 - 03-OCT-14. [Details]
(2013) Keystone Symposium ‘Genome Instability and Repair’,
Ciaran Morrison (2013) Selected abstract. [Conference Organising Committee Chairperson], Keystone Symposium ‘Genome Instability and Repair’, Banff, AB, Canada , 02-MAR-13 - 06-MAR-13. [Details]
(2012) 28th Radiation Biology Centre- National Institute of Radiological Sciences International Symposium,
Ciaran Morrison (2012) Invited speaker. [Invited Oral Presentation], 28th Radiation Biology Centre- National Institute of Radiological Sciences International Symposium, Kyoto, Japan , 26-NOV-12 - 29-NOV-12. [Details]
(2012) International Seminar on 'Genetic Discrimination – Transatlantic Perspectives on the Case for a European Level Legal Response',
Ciaran Morrison (2012) Invited speaker. [Invited Oral Presentation], International Seminar on 'Genetic Discrimination – Transatlantic Perspectives on the Case for a European Level Legal Response', European Parliament, Brussels, Belgium , 06-MAR-12 - 06-MAR-12. [Details]
(2010) EMBO Workshop: The Interface between the Ubiquitin Family and the DNA Damage Response,
Ciaran Morrison (2010) Selected abstract. [Oral Presentation], EMBO Workshop: The Interface between the Ubiquitin Family and the DNA Damage Response, Rovinj, Croatia , 01-SEP-10 - 05-SEP-10. [Details]
(2010) UK Environmental Mutagen Society annual meeting,
Ciaran Morrison (2010) Plenary talk. [Invited Oral Presentation], UK Environmental Mutagen Society annual meeting, Buxton, UK , 12-JUL-10 - 14-JUL-10. [Details]
(2010) DT40 as a model vertebrate genetic system,
Multiple speakers and participants (2010) EMBO Practical Course organiser. [Conference Organising Committee Chairperson], DT40 as a model vertebrate genetic system, Galway , 14-JUN-10 - 18-JUN-10. [Details]
(2008) Jacques Monod Conference on ‘Biological Responses to DNA damage’,
Ciaran Morrison (2008) Selected abstract. [Oral Presentation], Jacques Monod Conference on ‘Biological Responses to DNA damage’, Roscoff, France , 11-OCT-08 - 15-OCT-08. [Details]
(2007) Keystone Symposium ‘Genome Instability and Repair’,
Ciaran Morrison (2007) Selected abstract. [Oral Presentation], Keystone Symposium ‘Genome Instability and Repair’, Breckenridge, Co., USA , 17-JAN-07 - 22-JAN-07. [Details]

Editorial

  Year Publication
(2022) How CEP164 ciliopathy mutations impair ciliogenesis.
Morrison, C.G. (2022) How CEP164 ciliopathy mutations impair ciliogenesis. London: Cell Press Editorial [DOI] [Details]
(2019) KIFC3 directs a centrosome cohesive force.
Morrison, CG (2019) KIFC3 directs a centrosome cohesive force. LONDON: NATURE PUBLISHING GROUP Editorial [DOI] [Details]
(2011) Getting permission How DNA damage causes centrosome amplification.
Inanc, B;Morrison, CG (2011) Getting permission How DNA damage causes centrosome amplification. AUSTIN: LANDES BIOSCIENCE Editorial [DOI] [Details]

Reviews

  Year Publication
(2021) Primary cilia and the DNA damage response: linking a cellular antenna and nuclear signals.
Morrison CG; (2021) Primary cilia and the DNA damage response: linking a cellular antenna and nuclear signals. Reviews [DOI] [Details]
(2020) Molecular causes of primary microcephaly and related diseases: a report from the UNIA Workshop.
Stracker TH;Morrison CG;Gergely F; (2020) Molecular causes of primary microcephaly and related diseases: a report from the UNIA Workshop. Reviews [DOI] [Details]
(2015) Centrosomes in the DNA damage response-the hub outside the centre.
Mullee, LI;Morrison, CG (2015) Centrosomes in the DNA damage response-the hub outside the centre. DORDRECHT: SPRINGER Reviews [DOI] [Details]
(2012) Such small hands: the roles of centrins/caltractins in the centriole and in genome maintenance.
Dantas, TJ;Daly, OM;Morrison, CG (2012) Such small hands: the roles of centrins/caltractins in the centriole and in genome maintenance. BASEL: SPRINGER BASEL AG Reviews [DOI] [Details]
(2011) The Nse2/Mms21 SUMO ligase of the Smc5/6 complex in the maintenance of genome stability.
Stephan, AK;Kliszczak, M;Morrison, CG (2011) The Nse2/Mms21 SUMO ligase of the Smc5/6 complex in the maintenance of genome stability. HOBOKEN: WILEY Reviews [DOI] [Details]
(2004) Chromosome damage and progression into and through mitosis in vertebrates.
Morrison, C;Rieder, CL (2004) Chromosome damage and progression into and through mitosis in vertebrates. AMSTERDAM: ELSEVIER SCIENCE BV Reviews [DOI] [Details]