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Biological and Chemical Sciences

Dr Caomhán Lyons

BSc.

Contact Details

Post Doctoral Researcher
School of Medicine
University of Galway
E: caomhan.lyons@universityofgalway.ie

Biography

Caomhán Lyons is a post-doctoral researcher in REMEDI since November 2023. He completed his PhD in October 2023 in the University of Galway entitled 'Autologous Peripheral Blood Endothelial Progenitor Cells as a Potential Therapy for Diabetic Critical Limb Ischemia'. Caomhán received his MSc in Cell and Tissue Engineering in Keele Unveristy in 2017 where he worked on developing a novel bioreactor to for corneal transplantation. He received his BSc in Undenominated Science in the University of Galway in 2016. His research focus is on endothelial colony forming cells and their potential for treating critical limb ischaemia with and without diabetes mellitus. Caomhán is an SFI funded researcher working on developing advanced therapeutic medicinal products using endothelial colony forming cells for critical limb ischaemia

Research Interests

Generating advanced therapies for diabetic critical limb ischaemia using endothelial colony forming cells

Research Projects

	Project	Start Date	End Date
	Hybrid advanced therapy medicinal products as next generation tissue engineered therapies for limb salvage in critical limb ischaemia	01-MAR-23
	Combinatorial Cell Therapy For Diabetes-Related Critical Limb Ischaemia.	01-NOV-17	31-OCT-23

Peer Reviewed Journals

	Year	Publication
	(2024)	'Enhancing endothelial colony-forming cells for treating diabetic vascular complications: challenges and clinical prospects' Liu, Y.; Lyons, C.J.; Ayu, C.; O'Brien, T. (2024) 'Enhancing endothelial colony-forming cells for treating diabetic vascular complications: challenges and clinical prospects'. Frontiers In Endocrinology, [DOI] [Details]
	(2024)	'Recent advances in endothelial colony-forming cells: from the transcriptomic perspective' Liu, Y.; Lyons, C.J.; Ayu, C.; O'Brien, T. (2024) 'Recent advances in endothelial colony-forming cells: from the transcriptomic perspective'. Journal of Translational Medicine, [Details]
	(2020)	'The Functionality of Endothelial-Colony-Forming Cells from Patients with Diabetes Mellitus Caomhán J Lyons 1, Timothy O'Brien 1' Lyons, C.J. and O'Brien, T. (2020) 'The Functionality of Endothelial-Colony-Forming Cells from Patients with Diabetes Mellitus Caomhán J Lyons 1, Timothy O'Brien 1'. Cells, 9 (7) [DOI] [Details]
	(2018)	'Recent Advances in Endothelial Progenitor Cells Toward Their Use in Clinical Translation' Keighron, C., Lyons, C.J., Creane, M., O'Brien, T. (2018) 'Recent Advances in Endothelial Progenitor Cells Toward Their Use in Clinical Translation'. Frontiers In Medicine, [DOI] [Details]

Conference Publications

	Year	Publication
	(2022)	*International Society for Cell and Gene Therapy* Lyons, C.J., Soomro, N., Straszewicz, A., McEvoy, R.P., Griffin T., Creane, M., O'Brien, T. (2022) Endothelial colony forming cells from patients with diabetes and critical limb ischaemia show similar functionality and higher frequency than ECFCs from age-matched controls International Society for Cell and Gene Therapy [Details]
	(2023)	*International Society of Cell and Gene Therapy* Lyons, C.J., McKeown, S., Liu, Y., Pedrini, E., Keane, A., Stitt, A., O'Brien, T. (2023) Investigating the molecular differences between ECFCs from patients with diabetic critical limb ischaemia and healthy controls International Society of Cell and Gene Therapy [DOI] [Details]
	(2022)	*International Society for Cell and Gene Therapy* Sanz Nogués, C., Keane, A., Chen, X., Horan, E., Creane, M., Lyons, C.J., Elliman, S.J., O'Brien, T. (2022) Anti-CD362+ selected human umbilical cord-derived mesenchymal stromal cells ameliorate skeletal muscle damage induced by ischemia International Society for Cell and Gene Therapy [Details]
	(2022)	*International Society for Cell and Gene Therapy* Keane, A., Sanz Nogués, C., Lyons, C.J., Jayasooriya, D., Goljanek-Whysall, K., O'Brien, T. (2022) miR-1, miR-133A, and miR-29B are potential regulators of skeletal muscle pathology in critical limb ischemia International Society for Cell and Gene Therapy [DOI] [Details]
	(2022)	*International Society for Cell and Gene Therapy* Creane, M., Sanz Nogués, C., Chen, X., Lyons, C.J., Stitt, A., O'Brien, T. (2022) Endothelial colony forming cell and CD362+ mesenchymal stromal cell (Orbcel-C) combinational cell therapy increase blood perfusion in a mouse model of hindlimb ischaemia International Society for Cell and Gene Therapy [Details]

Education

Year	Institution	Qualification	Subject
2016	National University of Ireland, Galway	BSc	Undenominated Science
2017	Keele University	MSc	Cell and Tissue Engineering
2023	University of Galway	PhD	ECFCs in diabetes and vascular disease

Reviews

	Journal	Role
	Plos One.	Reviewer

Current Postgraduate Students (Taught)

	Name	Degree	Primary Supervisor
	Ella Morrison	Msc

Modules Taught

Term/Year	Module Title	Module Code	Subject / Desc
2019 - Present	Cellular Manufacturing	MD1521
2023/24	Cell Translational Therapy	REM502	Biodistribution, Potency, Toxicity
2019 - Present	Regenerative Medicine	REM504
2022	Gene Technologies and Molecular Medicine	BI206
2022	Biomolecules, Metabolism and Energy	MD138