Dr Caomhán Lyons

BSc.

Contact Details

Post Doctoral Researcher
School of Medicine
University of Galway
E: caomhan.lyons@universityofgalway.ie
 
researcher
 

Biography

Caomhán Lyons is a post-doctoral researcher in REMEDI since November 2023. He completed his PhD in October 2023 in the University of Galway entitled 'Autologous Peripheral Blood Endothelial Progenitor Cells as a Potential Therapy for Diabetic Critical Limb Ischemia'. Caomhán received his MSc in Cell and Tissue Engineering in Keele Unveristy in 2017 where he worked on developing a novel bioreactor to for corneal transplantation. He received his BSc in Undenominated Science in the University of Galway in 2016. His research focus is on endothelial colony forming cells and their potential for treating critical limb ischaemia with and without diabetes mellitus. Caomhán is an SFI funded researcher working on developing advanced therapeutic medicinal products using endothelial colony forming cells for critical limb ischaemia

Research Interests

Generating advanced therapies for diabetic critical limb ischaemia using endothelial colony forming cells

Research Projects

  Project Start Date End Date
Hybrid advanced therapy medicinal products as next generation tissue engineered therapies for limb salvage in critical limb ischaemia 01-MAR-23
Combinatorial Cell Therapy For Diabetes-Related Critical Limb Ischaemia. 01-NOV-17 31-OCT-23

Peer Reviewed Journals

  Year Publication
(2024) 'Enhancing endothelial colony-forming cells for treating diabetic vascular complications: challenges and clinical prospects'
Liu, Y.; Lyons, C.J.; Ayu, C.; O'Brien, T. (2024) 'Enhancing endothelial colony-forming cells for treating diabetic vascular complications: challenges and clinical prospects'. Frontiers In Endocrinology, [DOI] [Details]
(2024) 'Recent advances in endothelial colony-forming cells: from the transcriptomic perspective'
Liu, Y.; Lyons, C.J.; Ayu, C.; O'Brien, T. (2024) 'Recent advances in endothelial colony-forming cells: from the transcriptomic perspective'. Journal of Translational Medicine, [Details]
(2020) 'The Functionality of Endothelial-Colony-Forming Cells from Patients with Diabetes Mellitus Caomhán J Lyons 1, Timothy O'Brien 1'
Lyons, C.J. and O'Brien, T. (2020) 'The Functionality of Endothelial-Colony-Forming Cells from Patients with Diabetes Mellitus Caomhán J Lyons 1, Timothy O'Brien 1'. Cells, 9 (7) [DOI] [Details]
(2018) 'Recent Advances in Endothelial Progenitor Cells Toward Their Use in Clinical Translation'
Keighron, C., Lyons, C.J., Creane, M., O'Brien, T. (2018) 'Recent Advances in Endothelial Progenitor Cells Toward Their Use in Clinical Translation'. Frontiers In Medicine, [DOI] [Details]

Conference Publications

  Year Publication
(2022) International Society for Cell and Gene Therapy
Lyons, C.J., Soomro, N., Straszewicz, A., McEvoy, R.P., Griffin T., Creane, M., O'Brien, T. (2022) Endothelial colony forming cells from patients with diabetes and critical limb ischaemia show similar functionality and higher frequency than ECFCs from age-matched controls International Society for Cell and Gene Therapy [Details]
(2023) International Society of Cell and Gene Therapy
Lyons, C.J., McKeown, S., Liu, Y., Pedrini, E., Keane, A., Stitt, A., O'Brien, T. (2023) Investigating the molecular differences between ECFCs from patients with diabetic critical limb ischaemia and healthy controls International Society of Cell and Gene Therapy [DOI] [Details]
(2022) International Society for Cell and Gene Therapy
Sanz Nogués, C., Keane, A., Chen, X., Horan, E., Creane, M., Lyons, C.J., Elliman, S.J., O'Brien, T. (2022) Anti-CD362+ selected human umbilical cord-derived mesenchymal stromal cells ameliorate skeletal muscle damage induced by ischemia International Society for Cell and Gene Therapy [Details]
(2022) International Society for Cell and Gene Therapy
Keane, A., Sanz Nogués, C., Lyons, C.J., Jayasooriya, D., Goljanek-Whysall, K., O'Brien, T. (2022) miR-1, miR-133A, and miR-29B are potential regulators of skeletal muscle pathology in critical limb ischemia International Society for Cell and Gene Therapy [DOI] [Details]
(2022) International Society for Cell and Gene Therapy
Creane, M., Sanz Nogués, C., Chen, X., Lyons, C.J., Stitt, A., O'Brien, T. (2022) Endothelial colony forming cell and CD362+ mesenchymal stromal cell (Orbcel-C) combinational cell therapy increase blood perfusion in a mouse model of hindlimb ischaemia International Society for Cell and Gene Therapy [Details]

Education

  Year Institution Qualification Subject
2016 National University of Ireland, Galway BSc Undenominated Science
2017 Keele University MSc Cell and Tissue Engineering
2023 University of Galway PhD ECFCs in diabetes and vascular disease

Reviews

  Journal Role
Plos One. Reviewer

Current Postgraduate Students (Taught)

  Name Degree Primary Supervisor
Ella Morrison Msc

Modules Taught

  Term/Year Module Title Module Code Subject / Desc
2019 - Present Cellular Manufacturing MD1521
2023/24 Cell Translational Therapy REM502 Biodistribution, Potency, Toxicity
2019 - Present Regenerative Medicine REM504
2022 Gene Technologies and Molecular Medicine BI206
2022 Biomolecules, Metabolism and Energy MD138

External Collaborators

  Name Organisation / Institute Country Description of Collaboration
Seppo Ylä-Herttuala University of Eastern Finland FINLAND