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Biological and Chemical Sciences

Dr. Andrea Erxleben

Ph.D., B.Sc.

Contact Details

Senior Lecturer
School of Chemistry
Room 150
Arts/Science Building
NUI Galway
T: Ext. 2483
E: andrea.erxleben@nuigalway.ie
 
researcher
 

Biography


  • since 2017: Senior Lecturer, NUI Galway
  • since 2007: Lecturer in Inorganic Chemistry, NUI Galway
  • 2004: Visiting Professor, Institute of Inorganic Chemistry of the University of Vienna, Austria
  • 2002 - 2006: “Privatdozent”, University of Dortmund, Germany
  • 2002:  “Habilitation”, University of Dortmund, Germany
  • 1995 - 1997: Postdoctoral fellow, McGill University, Montréal
  • 1995: Dr. rer. nat. (PhD), University of Dortmund, Germany
  • 1992: "Dipl.-Chem", University of Dortmund, Germany

 

Research Interests

My research interests comprise Medicinal Inorganic Chemistry and Pharmaceutical Solid State Chemistry. Research activities in the area of Medicinal Inorganic Chemistry are centered on the synthesis and study of anticancer metallodrugs. A specific focus is on the development of new Pt(IV) anticancer pro-drugs with reduced side effects, metal complexes with receptor-specific carriers for target-delivery and selective accumulation into cancer tissue and on metal complexes that exhibit anticancer activity by irreversibly cleaving the tumour cell DNA. My research activities in the field of solid state chemistry of pharmaceuticals are aimed at improving the bioavailability and thus the therapeutic efficacy of poorly soluble drugs, including antibiotics, via co-amorphisation, co-crystallisation, control of crystal size and habit and polymorph control.

Research Projects

  Project Start Date End Date
SSPC Centre for Pharmaceutical Research - Andrea Erxleben - Materials - Phase 2 01-JUN-19 31-MAY-25
TSPO METALLODRUGS - Novel, highly effective and selective anticancer metallodrugs 01-FEB-18 31-JAN-22
IRC Postdoctoral Fellowship 2016 Leila Tabrizi - Novel anticancer theranostics targeting the translocator protein 01-OCT-16 30-SEP-18
ROYAL EMBASSY OF SAUDI ARABIA MS. MONEERH ABDULLAH J ALSUBAIE 01-SEP-16 31-AUG-18
13th International Symposium on Applied Bioinorganic Chemistry (ISABC13) 01-APR-15 30-SEP-16
Saudi Arabia - Marwah Hamdam Mohammad Aljohani - Andrea Erxleben (PI) 05-JAN-15 04-JAN-22
ROYAL EMBASSY OF SAUDI ARABIA AWATIF RASHED ZABIN ALMOTAIRY A ERXLEBEN 01-SEP-14 31-AUG-18
SYNTHESIS AND SOLID STATE PHARMACEUTICAL CENTRE(SSPC) A ERXLEBEN 01-JUN-13 31-MAY-19
SYNTHESIS & SOLID STATE PHARMACEUTICAL CENTRE(SSPC) INDUSTRY ACCOUNT A ERXLEBEN 01-JUN-13 31-MAY-19
SYNTHESIS AND BIOLOGICAL ACTIVITY OF CU(ii) METALLONUCLEASES A ERXLEBEN 01-JUN-13 13-MAR-14
SFI INCOMING SHORT TERM TRAVEL FELLOWSHIP 07 SK B1191-ISTFF 11 ANDREA ERXLEBEN 01-JAN-12 25-FEB-14
STOKES LECTURESHIP IN MEDICINAL CHEMISTRY 01-SEP-08 30-JUN-15
QUALIFICATION OF DIFFERENT SOLID STATE FORMS 5 MERCAPTOPURINE BY NEAR INFRARED SPECTROSCOPY COMBINED WITH MULTIVARIATE ANALYSIS A ERXLEBEN 03-JUN-13 23-JUL-13
FUNCTIONALIZED LOCKED NUCLEIC ACIDS, ANDREA ERXLEBEN 01-SEP-11 30-NOV-16
IRCSET EMBARK POSTGRAD NOEL BRYNE A ERXLEBEN 01-OCT-09 30-SEP-13
IRCSET FELLOWSHIP ROBERT WHIRISKEY ANDREA ERXLEBEN 01-OCT-08 02-NOV-13
MF08P03 CATALYSTS FOR DNA CLEAVAGE A ERXLEBEN 01-JAN-09 31-DEC-09

Contract Researchers

  Researcher Name Project Role Funding Body
Dr Pol MacFhionghaile Synthesis and Solid State Pharmaceutical Centre Postdoctoral Researcher
Dr Leila Trabizi Novel anticancer theranostics targeting the translocator protein Postdoctoral Researcher

Peer Reviewed Journals

  Year Publication
(2020) 'Glycosyl squaramides, a new class of supramolecular gelators'
14. T. Velasco-Torrijos, J. Ramos, S. Arufe, H. Martin, D. A. Rooney, R. B. P. Elmes, A. Erxleben, R. Moreira, (2020) 'Glycosyl squaramides, a new class of supramolecular gelators'. Soft Matter, 16 :7916-7926 [Details]
(22) 'Salts, Binary and Ternary Cocrystals of Pyrimethamine: Mechanosynthesis, Solution Crystallization, and Crystallization from the Gas Phase'
Ciaran O’Malley, Chloe Bouchet, Grayce Manyara, Niamh Walsh, Patrick McArdle, Andrea Erxleben (22) 'Salts, Binary and Ternary Cocrystals of Pyrimethamine: Mechanosynthesis, Solution Crystallization, and Crystallization from the Gas Phase'. Crystal Growth & Design, [DOI] [Details]
(2022) 'Differences in Coformer Interactions of the 2,4-Diaminopyrimidines Pyrimethamine and Trimethoprim'
Alaa Eldin Refat, L.,O'Malley, C.,Simmie, J. M.,McArdle, P.,Erxleben, A. (2022) 'Differences in Coformer Interactions of the 2,4-Diaminopyrimidines Pyrimethamine and Trimethoprim'. Crystal Growth & Design, 22 (5) [Details]
(2022) 'Formation of Salts and Molecular Ionic Cocrystals of Fluoroquinolones and Dicarboxylic Acids'
O'Malley, C.,McArdle, P.,Erxleben, A. (2022) 'Formation of Salts and Molecular Ionic Cocrystals of Fluoroquinolones and Dicarboxylic Acids'. Crystal Growth & Design, 22 (5):3060-3071 [Details]
(2021) 'Dual-drug amorphous formulation of gliclazide'
Marwah Aljohani, Patrick McArdle, Andrea Erxleben (2021) 'Dual-drug amorphous formulation of gliclazide'. Drug Development And Industrial Pharmacy, [DOI] [ARAN Link] [Details]
(2021) 'Au(I) Complexes with a Quinazoline Carboxamide Alkynyl Ligand: Synthesis, Cytotoxicity and Mechanistic Studies'
4. L. Tabrizi, W. S. Yang, C. Chintha, L. Morrison, A. Samali, J. W. Ramos, A. Erxleben (2021) 'Au(I) Complexes with a Quinazoline Carboxamide Alkynyl Ligand: Synthesis, Cytotoxicity and Mechanistic Studies'. European Journal Of Inorganic Chemistry, [DOI] [Details]
(2021) 'Crystallization of Organic Salts from the Gas Phase: When Does Proton Transfer Take Place?'
Ciarán O’Malley, Andrea Erxleben, Patrick McArdle, John M. Simmie (2021) 'Crystallization of Organic Salts from the Gas Phase: When Does Proton Transfer Take Place?'. Crystal Growth & Design, [DOI] [ARAN Link] [Details]
(2021) 'Expanding the NUIG MOF family: Synthesis and characterization of new MOFs for selective CO2adsorption, metal ion removal from aqueous systems, and drug delivery applications'
Winterlich, M.,McHugh, D.,O'Toole, E.,Skordi, K.,O'Malley, C.,Sanii, R.,Tasiopoulos, A.,Erxleben, A.,Mayans, J.,Morrison, L.,McArdle, P.,Zaworotko, M. J.,Tylianakis, E.,Froudakis, G.,Papatriantafyllopoulou, C. (2021) 'Expanding the NUIG MOF family: Synthesis and characterization of new MOFs for selective CO2adsorption, metal ion removal from aqueous systems, and drug delivery applications'. Dalton Transactions, 50 (20) [Details]
(2021) 'Manipulating Cocrystal Size and Morphology using a Combination of Temperature Cycling and Additives'
Francesco Civati, Vaclav Svoboda, Stephanie Jane Urwin, Patrick McArdle, Andrea Erxleben, D. Croker, Joop ter Horst (2021) 'Manipulating Cocrystal Size and Morphology using a Combination of Temperature Cycling and Additives'. Crystal Growth & Design, [DOI] [ARAN Link] [Details]
(2021) 'Salts, binary and ternary cocrystals of pyrimethamine: mechanosynthesis, solution crystallization and crystallization from the gas phase'
C. O’Malley, C. Bouchet, G. Manyara, N. Walsh, P. McArdle, A. Erxleben, (2021) 'Salts, binary and ternary cocrystals of pyrimethamine: mechanosynthesis, solution crystallization and crystallization from the gas phase'. Crystal Growth & Design, [DOI] [ARAN Link] [Details]
(2021) 'Sublimation - a green route to new solid-¿state forms'
McArdle, P.; Erxleben, A. (2021) 'Sublimation - a green route to new solid-¿state forms'. Crystengcomm, 23 [Details]
(2021) 'Unprecedented morphology control of gas phase cocrystal growth using multi zone heating and tailor made additives'
O'Malley, C;Erxleben, A;Kellehan, S;McArdle, P (2021) 'Unprecedented morphology control of gas phase cocrystal growth using multi zone heating and tailor made additives'. Chemical Communications, 56 :5657-5660 [DOI] [ARAN Link] [Details]
(2021) 'Factors controlling persistent needle crystal Growth: The importance of dominant 1D secondary bonding, stacked structures and vdW contact'
2. F. Civati, C. O'Malley, A. Erxleben, P. McArdle (2021) 'Factors controlling persistent needle crystal Growth: The importance of dominant 1D secondary bonding, stacked structures and vdW contact'. Crystal Growth & Design, [DOI] [Details]
(2020) 'Spontaneous Solid-State Cocrystallization of Caffeine and Urea'
MacFhionnghaile, P,Crowley, CM,McArdle, P,Erxleben, A (2020) 'Spontaneous Solid-State Cocrystallization of Caffeine and Urea'. Crystal Growth & Design, 20 :736-745 [DOI] [ARAN Link] [Details]
(2020) 'The Very Different Effect of Water on Nucleation, Crystallization, and Hydrate Stability of Zingerone and Vanillate Esters'
Aljohani, M,McArdle, P,Erxleben, A (2020) 'The Very Different Effect of Water on Nucleation, Crystallization, and Hydrate Stability of Zingerone and Vanillate Esters'. Crystal Growth & Design, 20 :627-635 [DOI] [ARAN Link] [Details]
(2020) 'Glycosyl squaramides, a new class of supramolecular gelators'
Ramos, J,Arufe, S,Martin, H,Rooney, D,Elmes, RBP,Erxleben, A,Moreira, R,Velasco-Torrijos, T (2020) 'Glycosyl squaramides, a new class of supramolecular gelators'. Soft Matter, 16 :7916-7926 [DOI] [Details]
(2020) 'Accessing New 5-α-(3,3-Disubstituted Oxindole)-Benzylamine Derivatives from Isatin: Stereoselective Organocatalytic Three Component Petasis Reaction'
Marques, C. S.,McArdle, P.,Erxleben, A.,Burke, A. J. (2020) 'Accessing New 5-α-(3,3-Disubstituted Oxindole)-Benzylamine Derivatives from Isatin: Stereoselective Organocatalytic Three Component Petasis Reaction'. European Journal of Organic Chemistry, 2020 (24) [Details]
(2020) 'Novel Pt(IV) prodrugs displaying antimitochondrial effects'
14. Tabrizi, L.; Thompson, K.; Mnich, K.; Chintha, C.; Gorman, A.; Morrison, L.; Luessing, J.; Lowndes, N.; Dockery, P.; Samali, A.; Erxleben, A. (2020) 'Novel Pt(IV) prodrugs displaying antimitochondrial effects'. Molecular Pharmaceutics, [Details]
(2020) 'Unprecedented morphology control of gas phase cocrystal growth using multi zone heating and tailor made additives'
O¿Malley, C.; Erxleben, A.; Kellehan, S.; McArdle, P. (2020) 'Unprecedented morphology control of gas phase cocrystal growth using multi zone heating and tailor made additives'. Chem Comm, [Details]
(2020) 'Influence of Excipients on Cocrystal Stability and Formation'
Marwah Aljohani, Patrick McArdle, and Andrea Erxleben1 (2020) 'Influence of Excipients on Cocrystal Stability and Formation'. Crystal Growth & Design, 20 [DOI] [ARAN Link] [Details]
(2020) 'Pt(IV) pro-drugs with an axial HDAC inhibitor demonstrate multimodal mechanisms involving DNA damage and apoptosis independent of cisplatin resistance in A2780/A2780cis cells'
Almotairy, ARZ,Montagner, D,Morrison, L,Devereux, M,Howe, O,Erxleben, A (2020) 'Pt(IV) pro-drugs with an axial HDAC inhibitor demonstrate multimodal mechanisms involving DNA damage and apoptosis independent of cisplatin resistance in A2780/A2780cis cells'. Journal Of Inorganic Biochemistry, 210 [DOI] [Details]
(2020) 'DNA binding and cell mechanistic studies of estrogen-functionalised Cu(II) complexes'
Barrett, Stephen; De Franco, Michele; Kellett, Andrew; Dempsey, Eithne; Marzano, Cristina; Erxleben, Andrea; Gandin, Valentina; Montagner, Diego (2020) 'DNA binding and cell mechanistic studies of estrogen-functionalised Cu(II) complexes'. Journal Of Biological Inorganic Chemistry, [Details]
(2019) 'Anticancer activity, DNA binding and cell mechanistic studies of estrogen-functionalised Cu(II) complexes'
Barrett, S;De Franco, M;Kellett, A;Dempsey, E;Marzano, C;Erxleben, A;Gandin, V;Montagner, D (2019) 'Anticancer activity, DNA binding and cell mechanistic studies of estrogen-functionalised Cu(II) complexes'. Journal Of Biological Inorganic Chemistry, [DOI] [Details]
(2019) 'Coordination polymers of Cd-II and Pb-II derived from bipyridine-glycoluril: influence of metal-ion size and counter-ions'
Tayade, SB;Markad, D;Kumbhar, AS;Erxleben, A;Chakravarty, D (2019) 'Coordination polymers of Cd-II and Pb-II derived from bipyridine-glycoluril: influence of metal-ion size and counter-ions'. Acta Crystallographica Section C-Structural Chemistry, 75 [DOI] [Details]
(2019) 'Cytotoxicity and ROS production of novel Pt(IV) oxaliplatin derivatives with indole propionic acid'
Tolan, D,Almotairy, ARZ,Howe, O,Devereux, M,Montagner, D,Erxleben, A (2019) 'Cytotoxicity and ROS production of novel Pt(IV) oxaliplatin derivatives with indole propionic acid'. Inorganica Chimica Acta, 492 :262-267 [DOI] [ARAN Link] [Details]
(2019) 'Investigation of the formation of drug-drug cocrystals and coamorphous systems of the antidiabetic drug gliclazide'
Aljohani, M,MacFhionnghaile, P,McArdle, P,Erxleben, A (2019) 'Investigation of the formation of drug-drug cocrystals and coamorphous systems of the antidiabetic drug gliclazide'. International Journal Of Pharmaceutics, 561 :35-42 [DOI] [ARAN Link] [Details]
(2019) 'Conversion of Gel-Forming Crystal Needles To Easily Processable More Equant Crystals Using High-Shear Ultralow Attrition Agitation: Accelerated Ostwald Ripening without Crystal Attrition'
Civati, F,Erxleben, A,Kellehan, S,McArdle, P (2019) 'Conversion of Gel-Forming Crystal Needles To Easily Processable More Equant Crystals Using High-Shear Ultralow Attrition Agitation: Accelerated Ostwald Ripening without Crystal Attrition'. Crystal Growth & Design, 19 :1502-1504 [DOI] [ARAN Link] [Details]
(2019) 'Shining Light on Growth-Dependent Surface Chemistry of Organic Crystals: A Polarized Raman Spectroscopic and Computational Study of Aspirin'
Pallipurath, AR,Skelton, JM,Erxleben, A,McArdle, P (2019) 'Shining Light on Growth-Dependent Surface Chemistry of Organic Crystals: A Polarized Raman Spectroscopic and Computational Study of Aspirin'. Crystal Growth & Design, 19 :1288-1298 [DOI] [Details]
(2018) 'Cocrystal forms of the BCS class IV drug sulfamethoxazole'
M. Alsubaie, M. Aljohani, A. Erxleben, P. McArdle (2018) 'Cocrystal forms of the BCS class IV drug sulfamethoxazole'. Crystal Growth And Design, [DOI] [ARAN Link] [Details]
(2018) 'A Phosphate-Targeted Dinuclear Cu(II) Complex Combining Major Groove Binding and Oxidative DNA Cleavage'
Z. Molphy, D. Montagner, S. Bhat, C. Slator, C. Long, A. Erxleben, A. Kellett (2018) 'A Phosphate-Targeted Dinuclear Cu(II) Complex Combining Major Groove Binding and Oxidative DNA Cleavage'. Nucleic Acid Research, 46 :9918-9931 [DOI] [ARAN Link] [Details]
(2018) 'Application of Ball Milling for Highly Selective Mechanochemical Polymorph Transformations'
N. Kamali, K. Gniado, P. McArdle, A. Erxleben (2018) 'Application of Ball Milling for Highly Selective Mechanochemical Polymorph Transformations'. Organic Process Research & Development, [DOI] [ARAN Link] [Details]
(2018) 'The use of sublimation catalysis and polycrystalline powder templates Application of Ball Milling for Highly Selective Mechanochemical Polymorph Transformations for polymorph control of gas phase crystallization'
N. Kamali, C. O’Malley, M. F. Mahon, A. Erxleben, P. McArdle (2018) 'The use of sublimation catalysis and polycrystalline powder templates Application of Ball Milling for Highly Selective Mechanochemical Polymorph Transformations for polymorph control of gas phase crystallization'. Crystal Growth And Design, 18 :3510-3516 [DOI] [ARAN Link] [Details]
(2018) 'The natural bile acid surfactant sodium taurocholate (NaTC) as a coformer in coamorphous systems: Enhanced physical stability and dissolution behavior of coamorphous drug-NaTc systems'
Gniado, K,MacFhionnghaile, P,McArdle, P,Erxleben, A (2018) 'The natural bile acid surfactant sodium taurocholate (NaTC) as a coformer in coamorphous systems: Enhanced physical stability and dissolution behavior of coamorphous drug-NaTc systems'. International Journal Of Pharmaceutics, 535 :132-139 [DOI] [ARAN Link] [Details]
(2018) 'Transition metal salen complexes in bioinorganic and medicinal chemistry'
Andrea Erxleben (2018) 'Transition metal salen complexes in bioinorganic and medicinal chemistry'. Inorganica Chimica Acta, [Details]
(2018) 'Interactions of Copper Complexes with Nucleic Acids'
A. Erxleben (2018) 'Interactions of Copper Complexes with Nucleic Acids'. Coordination Chemistry Reviews, 360 :92-121 [Details]
(2017) 'A Comprehensive Cocrystal Screening Study of Chlorothiazide'
Aljohani, M,Pallipurath, AR,McArdle, P,Erxleben, A (2017) 'A Comprehensive Cocrystal Screening Study of Chlorothiazide'. Crystal Growth & Design, 17 :5223-5232 [DOI] [ARAN Link] [Details]
(2017) 'A Cu(II) complex targeting the translocator protein: in vitro and in vivo antitumor potential and mechanistic insights'
Montagner, D., Fresch, B., Browne, K., Gandin, V., Erxleben, A. (2017) 'A Cu(II) complex targeting the translocator protein: in vitro and in vivo antitumor potential and mechanistic insights'. Chemical Communications, 53 :134-137 [DOI] [ARAN Link] [Details]
(2017) 'A comprehensive spectroscopic study of the polymorphs of diflunisal and their phase transformations'
Pallipurat, A.R., Civati, F., Sibikc, J., Crowley, C., Zeitler, A.J., McArdle, P., Erxleben, A. (2017) 'A comprehensive spectroscopic study of the polymorphs of diflunisal and their phase transformations'. International Journal Of Pharmaceutics, [ARAN Link] [Details]
(2017) 'Antitumor platinum(IV) derivatives of carboplatin and the histone deacetylase inhibitor 4-phenylbutyric acid'
A.R.Z. Almotairy, V. Gandin, L. Morrison, C. Marzano, D. Montagner, A. Erxleben (2017) 'Antitumor platinum(IV) derivatives of carboplatin and the histone deacetylase inhibitor 4-phenylbutyric acid'. J. Inorg. Biochem, [ARAN Link] [Details]
(2017) 'Investigation of Non-covalent Interactions of Metal Complexes with DNA in Cell-free Systems'
Erxleben, A (2017) 'Investigation of Non-covalent Interactions of Metal Complexes with DNA in Cell-free Systems'. Chimia, 71 :102-111 [DOI] [ARAN Link] [Details]
(2016) 'Unexpected effects of catalytic amounts of additives on crystallization from the gas phase: Depression of the Sublimation Temperature and Polymorph Control'
Kamali, N., Erxleben, A., McArdle, P. (2016) 'Unexpected effects of catalytic amounts of additives on crystallization from the gas phase: Depression of the Sublimation Temperature and Polymorph Control'. Crystal Growth & Design, 16 :2492-2495 [DOI] [ARAN Link] [Details]
(2016) 'The influence of co-formers on the dissolution rates of co-amorphous sulfamerazine/excipient systems'
Gniado, K., Lobmann, K., Rades, T., Erxleben, A. (2016) 'The influence of co-formers on the dissolution rates of co-amorphous sulfamerazine/excipient systems'. International Journal Of Pharmaceutics, 504 :20-26 [DOI] [ARAN Link] [Details]
(2016) 'Tailoring cocrystal and salt formation and controlling the crystal habit of diflunisal'
Pallipurath, A.R., Civati, F., Eziashi, M., Omar, E., McArdle, P., Erxleben, A. (2016) 'Tailoring cocrystal and salt formation and controlling the crystal habit of diflunisal'. Crystal Growth & Design, 16 :6468-6478 [DOI] [ARAN Link] [Details]
(2016) 'DNA binding, cleavage and cytotoxicity of a novel dimetallic Fe(III) triaza-cyclononane complex'
Araujo, T.P., Gandin, V., Kavanagh, P., Braude, J.P., Nodari, L., Montagner, D., Erxleben, A. (2016) 'DNA binding, cleavage and cytotoxicity of a novel dimetallic Fe(III) triaza-cyclononane complex'. Inorganica Chimica Acta, 452 :170-175 [DOI] [ARAN Link] [Details]
(2016) 'Effects of material thickness and processing method on poly(lactic-co-glycolic acid) degradation and mechanical performance'
Shirazi, R.N., Aldabbagh, F., Ronan, W., Erxleben, A., Rochev, Y., McHugh, P. (2016) 'Effects of material thickness and processing method on poly(lactic-co-glycolic acid) degradation and mechanical performance'. Journal Of Materials Science-Materials In Medicine, 27 (10):1-12 [DOI] [ARAN Link] [Details]
(2016) 'Ruthenium(II) polypyridyl complexes with hydrophobic ancillary ligand as A beta aggregation inhibitors'
Vyas, N.A., Ramteke, S.N., Kumbhar, A.S., Kulkarni, P.P., Jani, V., Sonawane, U.B., Joshi, R.R., Joshi, B., Erxleben, A. (2016) 'Ruthenium(II) polypyridyl complexes with hydrophobic ancillary ligand as A beta aggregation inhibitors'. European Journal Of Medicinal Chemistry, 121 :793-802 [DOI] [Details]
(2016) 'Copper(II) mixed-ligand polypyridyl complexes with doxycycline - structures and biological evaluation'
Abosede, O.O.,Vyas, N.A., Singh, S.B., Kumbhar, A.S., Kate, A., Kumbhar, A.A., Khan, A., Erxleben, A., Smith, P., de Kock, C., Hoffmann, F., Obaleye, J.A. (2016) 'Copper(II) mixed-ligand polypyridyl complexes with doxycycline - structures and biological evaluation'. Dalton Transactions, 45 :3003-3012 [DOI] [Details]
(2016) 'Application of vibrational spectroscopy to study solid-state transformations of pharmaceuticals'
Erxleben, A. (2016) 'Application of vibrational spectroscopy to study solid-state transformations of pharmaceuticals'. Current Pharmaceutical Design, 22 (32):4883-4911 [DOI] [ARAN Link] [Details]
(2016) 'Oxidative stress induced by Pt(IV) pro-drugs based on the cisplatin scaffold and indole carboxylic acids in axial position'
Tolan, D., Gandin, V., Morrison, L., El-Nahas, A., Marzano, C., Montagner, D., Erxleben, A. (2016) 'Oxidative stress induced by Pt(IV) pro-drugs based on the cisplatin scaffold and indole carboxylic acids in axial position'. Scientific Reports, 6 [DOI] [ARAN Link] [Details]
(2015) 'Water-based ultrasonic synthesis of SbSI nanoneedles'
Gladkovskaya, O., Rybina, I., Gun'ko, Y.K., Erxleben, A., O'Connor, G.M., Rochev, Y. (2015) 'Water-based ultrasonic synthesis of SbSI nanoneedles'. Materials Letters, 160 :113-116 [DOI] [Details]
(2015) 'Cytotoxicity and antimicrobial activity of triorganotin(IV) complexes of phenylcyanamide prepared by sonochemical synthesis'
Tabrizi, L., McArdle, P., Erxleben, A., Chiniforoshan, H. (2015) 'Cytotoxicity and antimicrobial activity of triorganotin(IV) complexes of phenylcyanamide prepared by sonochemical synthesis'. Inorganica Chimica Acta, 438 :94-104 [DOI] [ARAN Link] [Details]
(2015) 'Nickel(II) and cobalt(II) complexes of lidocaine: Synthesis, structure and comparative in vitro evaluations of biological perspectives'
Tabrizi, L., McArdle, P., Erxleben, A., Chiniforoshan, H. (2015) 'Nickel(II) and cobalt(II) complexes of lidocaine: Synthesis, structure and comparative in vitro evaluations of biological perspectives'. European Journal Of Medicinal Chemistry, 103 :516-529 [DOI] [Details]
(2015) 'Crystalline adducts of the Lawsone molecule (2-hydroxy-1,4-naphthaquinone): optical properties and computational modelling'
Pallipurath, A., Skelton, J.M., Delori, A., Duffy, C., Erxleben, A., Jones, W. (2015) 'Crystalline adducts of the Lawsone molecule (2-hydroxy-1,4-naphthaquinone): optical properties and computational modelling'. Crystengcomm, 17 :7684-7692 [DOI] [ARAN Link] [Details]
(2015) 'Sulfamerazine: Understanding the influence of slip planes in the polymorphic phase transformation through X-ray crystallographic studies and ab initio lattice dynamics'
Pallipurath, A.R., Skelton, J.M., Warren, M.R., Kamali, N., McArdle, P., Erxleben, A. (2015) 'Sulfamerazine: Understanding the influence of slip planes in the polymorphic phase transformation through X-ray crystallographic studies and ab initio lattice dynamics'. Molecular Pharmaceutics, 12 :3735-3748 [DOI] [ARAN Link] [Details]
(2015) 'DNA damage and induction of apoptosis in pancreatic cancer cells by a new dinuclear bis(triazacyclonane) copper complex'
Montagner, D., Gandin, V., Marzano, C., Erxleben, A. (2015) 'DNA damage and induction of apoptosis in pancreatic cancer cells by a new dinuclear bis(triazacyclonane) copper complex'. Journal Of Inorganic Biochemistry, 145 :101-107 [DOI] [ARAN Link] [Details]
(2015) 'Properties and applications of flavonoid metal complexes'
Kasprzak, MM,Erxleben, A,Ochocki, J (2015) 'Properties and applications of flavonoid metal complexes'. Rsc Advances, 5 :45853-45877 [DOI] [Details]
(2015) 'Anisotropic crystal growth in flat and nonflat systems: The important influence of van der Waals contact molecular stacking on crystal growth and dissolution'
Walshe, N., Crushell, M., Karpinska, J., Erxleben, A., McArdle, P. (2015) 'Anisotropic crystal growth in flat and nonflat systems: The important influence of van der Waals contact molecular stacking on crystal growth and dissolution'. Crystal Growth & Design, 15 [Details]
(2015) 'Hydrogen bonding networks and solid-state conversions in benzamidinium salts'
Kamali, N., Aljohani, M., McArdle, P., Erxleben, A. (2015) 'Hydrogen bonding networks and solid-state conversions in benzamidinium salts'. Crystal Growth & Design, 15 :3905-3916 [DOI] [ARAN Link] [Details]
(2014) 'Phosphate diester cleavage, DNA interaction and cytotoxic Activity of a bimetallic bis(1,4,7-triazacyclononane) zinc complex'
Montagner, D., Gandin, V., Marzano, C., Erxleben, A. (2014) 'Phosphate diester cleavage, DNA interaction and cytotoxic Activity of a bimetallic bis(1,4,7-triazacyclononane) zinc complex'. European Journal Of Inorganic Chemistry, :4084-4092 [DOI] [ARAN Link] [Details]
(2014) 'Nanomechanical properties of poly (lactic-co-glycolic) acid film during degradation'
Shirazi, R.N., Aldabbagh, F., Erxleben, A., Rochev, Y., McHugh, P.E. (2014) 'Nanomechanical properties of poly (lactic-co-glycolic) acid film during degradation'. Acta Biomaterialia, 10 :4695-4703 [DOI] [Details]
(2014) 'Effects of ball-milling and cryomilling on sulfamerazine polymorphs: A quantitative study'
Macfhionnghaile, P,, Hu, Y,, Gniado, K., Curran, S., Mcardle, P., Erxleben, A. (2014) 'Effects of ball-milling and cryomilling on sulfamerazine polymorphs: A quantitative study'. Journal Of Pharmaceutical Sciences, 103 :1766-1778 [DOI] [ARAN Link] [Details]
(2014) 'Mechanochemical reaction of sulfathiazole with carboxylic acids: Formation of a cocrystal, a salt, and coamorphous solids'
Hu, Y., Gniado, K., Erxleben, A., McArdle, P. (2014) 'Mechanochemical reaction of sulfathiazole with carboxylic acids: Formation of a cocrystal, a salt, and coamorphous solids'. Crystal Growth & Design, 14 :803-813 [DOI] [Details]
(2013) '17β-Hydroxy-17α-methylandrosta-1,4- dien-3-one'
Karpinska, J., Erxleben, A., McArdle, P. (2013) '17β-Hydroxy-17α-methylandrosta-1,4- dien-3-one'. Acta Crystallographica Section E-Structure Reports Online, E69 [Details]
(2013) 'A comprehensive near infrared spectroscopic study of the limits of quantitative analysis of sulfathiazole polymorphism'
MacFhionnghaile, P., Hu, Y., McArdle, P., Erxleben, A. (2013) 'A comprehensive near infrared spectroscopic study of the limits of quantitative analysis of sulfathiazole polymorphism'. Journal Of Near Infrared Spectroscopy, 21 :55-66 [DOI] [Details]
(2013) 'Solid-state transformations of sulfathiazole polymorphs: The effects of milling and humidity'
Hu, Y., Erxleben, A., Hodnett, B.K., Li, B.Y., McArdle, P,, Rasmuson, A.C., Ryder, A.G. (2013) 'Solid-state transformations of sulfathiazole polymorphs: The effects of milling and humidity'. Crystal Growth & Design, 13 :3404-3413 [DOI] [ARAN Link] [Details]
(2013) 'Amorphous solid dispersions of sulfonamide/soluplus (R) and sulfonamide/PVP prepared by ball milling'
Caron, V., Hu, Y., Tajber, L., Erxleben, A., Corrigan, O.I., McArdle, P, Healy, A.M. (2013) 'Amorphous solid dispersions of sulfonamide/soluplus (R) and sulfonamide/PVP prepared by ball milling'. Aaps Pharmscitech, 14 :464-474 [DOI] [Details]
(2013) 'Applications of low temperature gradient sublimation in vacuo: Rapid production of high quality crystals. The first solvent-free crystals of ethinyl estradiol'
Karpinska, J., Erxleben, A., McArdle, P. (2013) 'Applications of low temperature gradient sublimation in vacuo: Rapid production of high quality crystals. The first solvent-free crystals of ethinyl estradiol'. Crystal Growth & Design, 13 :1122-1130 [DOI] [Details]
(2013) 'Investigation of the capacity of low glass transition temperature excipients to minimize amorphization of sulfadimidine on comilling'
Curtin, V., Amharar, Y., Hu, Y., Erxleben, A., McArdle, P., Caron, V., Tajber, L., Corrigan, O.I., Healy, A.M. (2013) 'Investigation of the capacity of low glass transition temperature excipients to minimize amorphization of sulfadimidine on comilling'. Molecular Pharmaceutics, 10 :386-396 [DOI] [Details]
(2013) 'Formation, physical stability, and quantification of process-induced disorder in cryomilled samples of a model polymorphic drug'
Hu, Y., Macfhionnghaile, P., Caron, V.,Tajber, L., Healy, A.M., Erxleben, A., McArdle, P. (2013) 'Formation, physical stability, and quantification of process-induced disorder in cryomilled samples of a model polymorphic drug'. Journal Of Pharmaceutical Sciences, 102 :93-103 [DOI] [ARAN Link] [Details]
(2013) 'Solvent-dependent switch of magnesium ions between different binding sites in a compartmental Schiff base ligand'
Coleman, F., Dux, D., Erxleben, A (2013) 'Solvent-dependent switch of magnesium ions between different binding sites in a compartmental Schiff base ligand'. Zeitschrift Fur Anorganische Und Allgemeine Chemie, 639 :1584-1589 [DOI] [Details]
(2012) 'Rapid hydrolysis of phosphate monoesters by zirconium(IV) complexes in neutral solution'
Coleman, F., Erxleben, A. (2012) 'Rapid hydrolysis of phosphate monoesters by zirconium(IV) complexes in neutral solution'. Polyhedron, 48 :104-109 [DOI] [ARAN Link] [Details]
(2011) 'Hydrogen bond directed honeycomb-like porous network structure of tris (bipyridyl-glycoluril)cobalt(III) chloride'
Kawade, VA,Kumbhar, AS,Erxleben, A,Pachfule, P,Banerjee, R (2011) 'Hydrogen bond directed honeycomb-like porous network structure of tris (bipyridyl-glycoluril)cobalt(III) chloride'. Crystengcomm, 13 :5289-5291 [DOI] [Details]
(2011) 'Supramolecular Structures and Tautomerism of Carboxylate Salts of Adenine and Pharmaceutically Relevant N-6-Substituted Adenine'
McHugh, C,Erxleben, A (2011) 'Supramolecular Structures and Tautomerism of Carboxylate Salts of Adenine and Pharmaceutically Relevant N-6-Substituted Adenine'. Crystal Growth & Design, 11 :5096-5104 [DOI] [ARAN Link] [Details]
(2011) 'Mixed ligand cobalt(II) picolinate complexes: synthesis, characterization, DNA binding and photocleavage'
Kawade, VA,Kumbhar, AA,Kumbhar, AS,Nather, C,Erxleben, A,Sonawane, UB,Joshi, RR (2011) 'Mixed ligand cobalt(II) picolinate complexes: synthesis, characterization, DNA binding and photocleavage'. Dalton Transactions, 40 :639-650 [DOI] [Details]
(2011) '17 beta-Hydroxy-17 alpha-methylandrostano[3,2-c]pyrazole, Stanozolol: The Crystal Structures of Polymorphs 1 and 2 and 10 Solvates'
Karpinska, J,Erxleben, A,McArdle, P (2011) '17 beta-Hydroxy-17 alpha-methylandrostano[3,2-c]pyrazole, Stanozolol: The Crystal Structures of Polymorphs 1 and 2 and 10 Solvates'. Crystal Growth & Design, 11 :2829-2838 [DOI] [Details]
(2010) 'Ga-III Complexes as Models for the M-III Site of Purple Acid Phosphatase: Ligand Effects on the Hydrolytic Reactivity Toward Bis(2,4-dinitrophenyl) phosphate'
Coleman, F,Hynes, MJ,Erxleben, A (2010) 'Ga-III Complexes as Models for the M-III Site of Purple Acid Phosphatase: Ligand Effects on the Hydrolytic Reactivity Toward Bis(2,4-dinitrophenyl) phosphate'. Inorganic Chemistry, 49 :6725-6733 [DOI] [ARAN Link] [Details]
(2010) 'Quantitative Analysis of Sulfathiazole Polymorphs in Ternary Mixtures by Attenuated Total Reflectance Infrared, Near-infrared and Raman Spectroscopy'
Hu, Y., Erxleben, A., Ryder, A.G., McArdle, P. (2010) 'Quantitative Analysis of Sulfathiazole Polymorphs in Ternary Mixtures by Attenuated Total Reflectance Infrared, Near-infrared and Raman Spectroscopy'. Journal of pharmaceutical and biomedical analysis, 53 (3):412-420 [DOI] [Details]
(2010) 'Binding and hydrolysis studies of antitumoural titanocene dichloride and Titanocene Y with phosphate diesters'
Erxleben, A,Claffey, J,Tacke, M (2010) 'Binding and hydrolysis studies of antitumoural titanocene dichloride and Titanocene Y with phosphate diesters'. Journal Of Inorganic Biochemistry, 104 :390-396 [DOI] [Details]
(2010) 'Synthesis, single-crystal and solution structure analysis and in vitro cytotoxic activity of two novel complexes of ruthenium(II) with in situ formed flavanone-based ligands'
Ochocki, J,Kasprzak, M,Checinska, L,Erxleben, A,Zyner, E,Szmigiero, L,Garza-Ortiz, A,Reedijk, J (2010) 'Synthesis, single-crystal and solution structure analysis and in vitro cytotoxic activity of two novel complexes of ruthenium(II) with in situ formed flavanone-based ligands'. Dalton Transactions, 39 :9711-9718 [DOI] [Details]
(2009) 'Synthesis, Crystal Structure and Electrochemical Studies of a Hydrazone Schiff Base Complex of Titanium(IV)'
Monfared, HH,Nazari, M,Mayer, P,Kamyabi, MA,Erxleben, A,Asgari, Z (2009) 'Synthesis, Crystal Structure and Electrochemical Studies of a Hydrazone Schiff Base Complex of Titanium(IV)'. Zeitschrift Fur Naturforschung Section B-A Journal Of Chemical Sciences, 64 :409-414 [Details]
(2009) 'Synthesis, spectroscopy and magnetism of novel metal complexes of 3-aminoflavone (3-af). X-ray crystal structure of 3-af and [Cu(3-af)(2)(NO3)(2)]'
Zurowska, B,Erxleben, A,Glinka, L,Leczycka, M,Zyner, E,Ochocki, J (2009) 'Synthesis, spectroscopy and magnetism of novel metal complexes of 3-aminoflavone (3-af). X-ray crystal structure of 3-af and [Cu(3-af)(2)(NO3)(2)]'. Inorganica Chimica Acta, 362 :739-744 [DOI] [Details]
(2009) 'Invited contribution to the special issue dedicated to Bernhard Lippert “Cu coordination to the aldehyde and hemiacetal form of 4-bromo-2-[2-diethylaminoethyl)ethylaminomethyl]-6-formylphenol: synthesis and structure of [CuHL)2X)2] X = NO3, ClO4) and [CuL’)]2”'
Erxleben,A. (2009) 'Invited contribution to the special issue dedicated to Bernhard Lippert “Cu coordination to the aldehyde and hemiacetal form of 4-bromo-2-[2-diethylaminoethyl)ethylaminomethyl]-6-formylphenol: synthesis and structure of [CuHL)2X)2] X = NO3, ClO4) and [CuL’)]2”'. Inorg. Chim. Acta, 362 :839-844 [Details]
(2007) 'Spontaneous reduction of mixed 2,2?-bipyridine/methylamine/chloro complexes of PtIV in water in the presence of light is accompanied by complex isomerization, loss of methylamine, and formation of a strong oxidant, presumably HOCl'
Nakabayashi,Y.,Erxleben, A.,Letinois, U.,Pratviel, G.,Meunier, B.,Holland, L.,Lippert, B. (2007) 'Spontaneous reduction of mixed 2,2?-bipyridine/methylamine/chloro complexes of PtIV in water in the presence of light is accompanied by complex isomerization, loss of methylamine, and formation of a strong oxidant, presumably HOCl'. Chemistry - A European Journal, 13 (14) [Details]
(2006) 'Interactions of molybdocene dichloride with histidine- and methionine-containing peptides'
Erxleben,A.,Kottmann, J. (2006) 'Interactions of molybdocene dichloride with histidine- and methionine-containing peptides'. Inorganica Chimica Acta, 359 (1) [Details]
(2006) 'Reaction behavior of molybdocene dichloride towards ribonucleosides and ribonucleoside monophosphates: Rare example of sugar coordination'
Erxleben,A.,Yovkova, L. (2006) 'Reaction behavior of molybdocene dichloride towards ribonucleosides and ribonucleoside monophosphates: Rare example of sugar coordination'. Inorganica Chimica Acta, 359 (8) [Details]
(2005) 'Synthesis and spectroscopy of diethyl (pyridinylmethyl)phosphates and their palladium (II) complexes: X-ray crystal structures of Pd(II) complexes'
Kalinowska,U.,Checinska, L.,Malecka, M.,Erxleben, A.,Lippert, B.,Ochocki,J. (2005) 'Synthesis and spectroscopy of diethyl (pyridinylmethyl)phosphates and their palladium (II) complexes: X-ray crystal structures of Pd(II) complexes'. Inorganica Chimica Acta, 358 (8) [Details]
(2005) 'Interaction of molybdocene dichloride with cysteine-containing peptides: Coordination, regioselective hydrolysis, and intramolecular aminolysis'
Erxleben,A. (2005) 'Interaction of molybdocene dichloride with cysteine-containing peptides: Coordination, regioselective hydrolysis, and intramolecular aminolysis'. Inorganic Chemistry, 44 (4) [Details]
(2004) 'Metal-mediated deamination of cytosine: Experiment and DFT calculations'
Sponer,J.E.,Miguel,P.J.S.,Rodriguez-Santiago,L.,Erxleben,A.,Krumm,M., Sodupe,M.,Sponer,J.,Lippert, B. (2004) 'Metal-mediated deamination of cytosine: Experiment and DFT calculations'. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 43 (40):5396-5399 [Details]
(2003) 'Inter- and intra-molecular condensation patterns of (en)PdII with trans-[a2PtL2]2+ (a = am(m)ine, L = 2-aminopyridine): PtPd3 and Pt2Pd4 species with multiple amide bridges. Unexpected trapping of a pair of nitrate ions by a Pt2Pd4 double cone'
Beck,B.,Schneider, A.,Freisinger, E.,Holthenrich, D.,Erxleben, A.,Albinati, A.,Zangrando, E., Randaccio, L.,Lippert, B. (2003) 'Inter- and intra-molecular condensation patterns of (en)PdII with trans-[a2PtL2]2+ (a = am(m)ine, L = 2-aminopyridine): PtPd3 and Pt2Pd4 species with multiple amide bridges. Unexpected trapping of a pair of nitrate ions by a Pt2Pd4 double cone'. Dalton Transactions, 12 [Details]
(2003) 'Coordination polymers derived from silver salts and an aliphatic N,O ligand'
Erxleben,A. (2003) 'Coordination polymers derived from silver salts and an aliphatic N,O ligand'. Inorganica Chimica Acta, (348) [Details]
(2003) 'Structures and properties of Zn(II) coordination polymers'
Erxleben A. (2003) 'Structures and properties of Zn(II) coordination polymers'. Coordination Chemistry Reviews, 246 (1-2) [Details]
(2002) 'Anion-dependent substitution of zinc by magnesium in mononuclear Schiff base complexes'
Hermann,J.,Schumacher, D.,Erxleben, A. (2002) 'Anion-dependent substitution of zinc by magnesium in mononuclear Schiff base complexes'. EUROPEAN JOURNAL OF INORGANIC CHEMISTRY, (9):2276-2280 [Details]
(2002) 'Silver co-ordination compounds with aliphatic nitriles containing amino nitrogen as H bond donor or additional metal binding site: formation of a ring, a chain, a polymeric sheet and a 3D polymeric channeled structure'
Erxleben,A. (2002) 'Silver co-ordination compounds with aliphatic nitriles containing amino nitrogen as H bond donor or additional metal binding site: formation of a ring, a chain, a polymeric sheet and a 3D polymeric channeled structure'. CrystEngComm, 4 :472-477 [Details]
(2002) 'Association patterns of platinated purine nucleobases in metal-modified pairs and triples'
Roitzsch,M.,Rother, I.B.,Willermann, M.,Erxleben, A.,Costisella, B.,Lippert, B. (2002) 'Association patterns of platinated purine nucleobases in metal-modified pairs and triples'. Inorganic Chemistry, 23 (41) [Details]
(2002) 'Model of the most abundant DNA interstrand cross-link of Transplatin: X-ray structures of two modifications and H bonding behavior in the solid state and in solution of trans-[Pt(NH3)2(1-MeC-N3)(9-EtGH-N7)](ClO4) 2·nH2O (1-MeC=1-methylcytosine; 9-EtGH=9-ethylguanine)'
Erxleben,A.,Metzger,S.,Britten, J.F.,Lock,C.J.L.,Albinati, A.,Lippert, B. (2002) 'Model of the most abundant DNA interstrand cross-link of Transplatin: X-ray structures of two modifications and H bonding behavior in the solid state and in solution of trans-[Pt(NH3)2(1-MeC-N3)(9-EtGH-N7)](ClO4) 2·nH2O (1-MeC=1-methylcytosine; 9-EtGH=9-ethylguanine)'. Inorganica Chimica Acta, (339) [Details]
(2001) 'Magnesium versus zinc coordination to multidentate Schiff base ligands'
Erxleben, A, Schumacher, D. (2001) 'Magnesium versus zinc coordination to multidentate Schiff base ligands'. EUROPEAN JOURNAL OF INORGANIC CHEMISTRY, (12):3039-3046 [Details]
(2001) 'Mono- and dinuclear zinc complexes derived from unsymmetric binucleating ligands: Synthesis, characterization, and formation of tetranuclear arrays'
Erxleben,A. (2001) 'Mono- and dinuclear zinc complexes derived from unsymmetric binucleating ligands: Synthesis, characterization, and formation of tetranuclear arrays'. Inorganic Chemistry, 2 (40) [Details]
(2001) 'Synthesis and structure of a helical coordination polymer: {[Zn-2bdaip)mu-OH)OH)]NO3 center dot 2H2)O}infinity) Hbdaip=2,6-bis{N-[2-dimethylamino)ethyl]-iminomethyl}-4-methylpihenol)'
Erxleben,A. (2001) 'Synthesis and structure of a helical coordination polymer: {[Zn-2bdaip)mu-OH)OH)]NO3 center dot 2H2)O}infinity) Hbdaip=2,6-bis{N-[2-dimethylamino)ethyl]-iminomethyl}-4-methylpihenol)'. INORGANIC CHEMISTRY, 40 (2):412-414 [Details]
(2001) 'Synthesis and structure of {[Ag(SalGly)]·0.33H2O}n: An infinite double helical coordination polymer'
Erxleben,A. (2001) 'Synthesis and structure of {[Ag(SalGly)]·0.33H2O}n: An infinite double helical coordination polymer'. Inorganic Chemistry, 12 (40) [Details]
(2001) 'Magnesium coordination to biomimetic ligands'
Erxleben, A.,Schumacher, D.,Hermann, J. (2001) 'Magnesium coordination to biomimetic ligands'. JOURNAL OF INORGANIC BIOCHEMISTRY, 86 (1) [Details]
(2000) 'trans-a2)PtII)- a = NH3, CH3NH2) modified purine base pairs and triples: Hydrogen bonding between self-complementary pairs and triples and heterometal Ag+) coordination leading to a 1 D helix'
Rother,I.B.,Freisinger, E.,Erxleben, A.,Lippert, B. (2000) 'trans-a2)PtII)- a = NH3, CH3NH2) modified purine base pairs and triples: Hydrogen bonding between self-complementary pairs and triples and heterometal Ag+) coordination leading to a 1 D helix'. INORGANICA CHIMICA ACTA, 300 :339-352 [Details]
(2000) 'Synthesis, crystal structure and solution behavior of a novel tetranuclear Zn(II) Schiff base complex'
Hermann J., Erxleben, A. (2000) 'Synthesis, crystal structure and solution behavior of a novel tetranuclear Zn(II) Schiff base complex'. Inorganica Chimica Acta, 1 (304) [Details]
(2000) 'Di- and poly-nuclear zincII) Schiff base complexes: synthesis, structural studies and reaction with an alpha-amino acid'
Erxleben, A, Hermann, J. (2000) 'Di- and poly-nuclear zincII) Schiff base complexes: synthesis, structural studies and reaction with an alpha-amino acid'. DALTON TRANSACTIONS, (4):569-575 [Details]
(1998) 'Interactions between [AuX4]-(X = Cl, CN) and cytosine and guanine model nucleobases: Salt formation with (hemi-) protonated bases, coordination, and oxidative degradation of guanine'
Schimanski,A., Freisinger,E., Erxleben, A.,Lippert, B. (1998) 'Interactions between [AuX4]-(X = Cl, CN) and cytosine and guanine model nucleobases: Salt formation with (hemi-) protonated bases, coordination, and oxidative degradation of guanine'. Inorganica Chimica Acta, 283 (1) [Details]
(1998) 'Bispurine) complexes of trans-a2)PtII): Preparation and X-ray structures of bis9-methyladenine) and mixed 9-methyladenine, 9-methylguanine complexes and chemistry relevant to Interactions between [AuX4]-) X = Cl, CN) and cytosine and guanine model nucleobases: salt formation with hemi-) protonated bases, coordination, and oxidative degradation of guanine'
Schimanski,A.,Freisinger, E.,Erxleben, A.,Lippert, B. (1998) 'Bispurine) complexes of trans-a2)PtII): Preparation and X-ray structures of bis9-methyladenine) and mixed 9-methyladenine, 9-methylguanine complexes and chemistry relevant to Interactions between [AuX4]-) X = Cl, CN) and cytosine and guanine model nucleobases: salt formation with hemi-) protonated bases, coordination, and oxidative degradation of guanine'. INORGANICA CHIMICA ACTA, 283 (1):223-232 [Details]
(1997) 'Metal-modified nucleobase pairs involving 7,9-dimethylguanine: trans- a2Pt(II) analogues (a = NH3 or CH3NH2) of Watson-Crick GC and homo GG pairs'
Metzger,S.,Erxleben, A.,Lippert, B. (1997) 'Metal-modified nucleobase pairs involving 7,9-dimethylguanine: trans- a2Pt(II) analogues (a = NH3 or CH3NH2) of Watson-Crick GC and homo GG pairs'. Journal of Biological Inorganic Chemistry, 2 (2) [Details]
(1997) 'Synthesis and Spectroscopy of Phosphonate Derivatives of Uracil and Thymine. X-Ray Crystal Structure of Diethyl 6-Uracilmethylphosphonate'
Ochocki,J.,Erxleben, A.,Lippert,B. (1997) 'Synthesis and Spectroscopy of Phosphonate Derivatives of Uracil and Thymine. X-Ray Crystal Structure of Diethyl 6-Uracilmethylphosphonate'. Journal of Heterocyclic Chemistry, 34 (4) [Details]
(1996) 'First examples of polymeric mixed-metal (Pt-Ag) complexes containing single acetamidate bridges: cis-[(NH3)2Pt(NHCOMe)2Ag]NO 3·4H2O and trans-[(NH3)2Pt(NHCOMe)2Ag]NO 3·1.5H2O'
Erxleben,A.,Lippert, B. (1996) 'First examples of polymeric mixed-metal (Pt-Ag) complexes containing single acetamidate bridges: cis-[(NH3)2Pt(NHCOMe)2Ag]NO 3·4H2O and trans-[(NH3)2Pt(NHCOMe)2Ag]NO 3·1.5H2O'. Journal of the Chemical Society - Dalton Transactions, (11) [Details]
(1996) 'Heteronuclear Pt-Pd, Pt2Cu and Pt2Ni complexes with bridging acetamidate: Crystal structures and spectroscopic studies'
Erxleben,A.,Albinati, A.,Lippert, B. (1996) 'Heteronuclear Pt-Pd, Pt2Cu and Pt2Ni complexes with bridging acetamidate: Crystal structures and spectroscopic studies'. Journal of the Chemical Society - Dalton Transactions, (9) [Details]
(1996) 'The Uracil C(5) Position as a Metal Binding Site: Solution and X-ray Crystal Structure Studies of PtII and HgII Compounds'
Hopp,M.,Erxleben,A.,Rombeck, I.,Lippert,B. (1996) 'The Uracil C(5) Position as a Metal Binding Site: Solution and X-ray Crystal Structure Studies of PtII and HgII Compounds'. Inorganic Chemistry, 35 (2) [Details]
(1996) 'Heteronuclear ?-1-methylcytosinato-N3,N4 complexes containing very short Pt?Cu dative bonds'
Fusch,G.,Fusch, E.C.,Erxleben, A.,Huttermann, J.,Scholl H.-J.,Lippert, B. (1996) 'Heteronuclear ?-1-methylcytosinato-N3,N4 complexes containing very short Pt?Cu dative bonds'. Inorganica Chimica Acta, 252 (1-2) [Details]
(1996) 'Ternary complex of cisplatin with glycine and 1-methyluracil: Cis-[(NH3)2Pt(glyH-N)(1-MeU-N3)]ClO 4·H2O'
Hohmann,S.,Erxleben,A.,Wienkotter, T.,Lippert, B. (1996) 'Ternary complex of cisplatin with glycine and 1-methyluracil: Cis-[(NH3)2Pt(glyH-N)(1-MeU-N3)]ClO 4·H2O'. Inorganica Chimica Acta, 247 (1) [Details]
(1996) 'Bispurine) complexes of trans-a2)PtII): Preparation and X-ray structures of bis9-methyladenine) and mixed 9-methyladenine, 9-methylguanine complexes and chemistry relevant to metal-modified nucleobase triples and quartets'
Schreiber,A.,Luth, M.S.,Erxleben, A.,Fusch, E.C.,Lippert, B. (1996) 'Bispurine) complexes of trans-a2)PtII): Preparation and X-ray structures of bis9-methyladenine) and mixed 9-methyladenine, 9-methylguanine complexes and chemistry relevant to metal-modified nucleobase triples and quartets'. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 118 (17):4124-4132 [Details]
(1995) 'Heteronuclear complexes as tools for the isolation of the minor rotamer of the parent compound: Synthesis and crystal structure determination of head-head and head-tail forms of trans-[(CH3NH2)2Pt(1-MeC-N3)2]2+ (1-MeC = 1-methylcytosine)'
Holtenrich ,D., Sovago, I., Fusch, G., Erxleben, A., Fusch, EC., Rombeck, I., Lippert, B.T, B. (1995) 'Heteronuclear complexes as tools for the isolation of the minor rotamer of the parent compound: Synthesis and crystal structure determination of head-head and head-tail forms of trans-[(CH3NH2)2Pt(1-MeC-N3)2]2+ (1-MeC = 1-methylcytosine)'. Zeitschrift Fur Naturforschung - Section B Journal Of Chemical Sciences, 50 (11):1767-1775 [Details]
(1994) 'Conversion of acetonitrile into acetamide in the co-ordination spheres of cis- and trans-MII(amine)2 (M = Pt or Pd). Solution and crystal structural studies'
Erxleben,A.,Mutikainen, I., Lippert, B. (1994) 'Conversion of acetonitrile into acetamide in the co-ordination spheres of cis- and trans-MII(amine)2 (M = Pt or Pd). Solution and crystal structural studies'. Dalton Transactions, (24):3667-3675 [Details]
(1994) '[(en)Pt(uracilate)]44+: A metal analogue of calix[4]arene. Similarities and differences with classical calix[4]arenes'
Rauter,H.,Hillgeris, E.C.,Erxleben, A.,Lippert, B. (1994) '[(en)Pt(uracilate)]44+: A metal analogue of calix[4]arene. Similarities and differences with classical calix[4]arenes'. Journal of the American Chemical Society, 116 (2) [Details]

Book Chapters

  Year Publication
(2022) 'Mitochondria as a Metallodrug Target for Therapeutic Purposes'
Andrea Erxleben (2022) 'Mitochondria as a Metallodrug Target for Therapeutic Purposes' In: Targeted Metallo-Drugs. Oxfordshire, UK: Taylor & Francis Group. [Details]

Edited Books

  Year Publication
(2020) Cocrystal Applications in Drug Delivery.
A. Erxleben (Ed.). (2020) Cocrystal Applications in Drug Delivery Cocrystal Applications in Drug Delivery. Basel, Switzerland: MPDI. [Details]

Special Issue Editor

  Year Publication
(2021) Special Issue Selected Papers from the 1st International Electronic Conference on Pharmaceutics (IECP 2020).
Andrea Erxleben, Elisabetta Gavini (2021) Special Issue Selected Papers from the 1st International Electronic Conference on Pharmaceutics (IECP 2020). Special Issue Editor [Details]
(2020) Cocrystal Applications in Drug Delivery.
A. Erxleben (2020) Cocrystal Applications in Drug Delivery. Special Issue Editor [Details]
(2021) Design of Macrocyclic Compounds for Biomedical Applications.
Padnya, Pavel L; Wu, Xin; Erxleben, Andrea; Braga, Susana S (2021) Design of Macrocyclic Compounds for Biomedical Applications. Special Issue Editor [Details]
(2022) Special issue of Frontiers in Oncology, Role of Platinum-Based Antitumor Prodrugs in Medicinal Inorganic Chemistry.
Nicola Margiotta, Mauro Ravera, Andrea Erxleben (2022) Special issue of Frontiers in Oncology, Role of Platinum-Based Antitumor Prodrugs in Medicinal Inorganic Chemistry. Special Issue Editor [Details]

Honours and Awards

  Year Title Awarding Body
2007 Stokes Lectureship Science Foundation Ireland
2002 'Forschungsstipendium' Deutsche Forschungsgemeinschaft
1999 'Lise-Meitner-Stipendium' 'Ministerium für Wissenschaft und Forschung (MSWF), NRW'
1995 Nato-Scholarship 'Deutscher Akademischer Austauschdienst'

Employment

  Employer Position From / To
McGill University, Montreal Postdoctoral Fellow 01-SEP-95 / 31-AUG-97
University of Dortmund 'Privatdozent' 01-DEC-02 /
NUI Galway Lecturer 01-JAN-07 /
University of Dortmund 'Habilitand' 01-SEP-97 / 30-NOV-02

Education

  Year Institution Qualification Subject
1995 University of Dortmund, Germany PhD Chemistry

Recent Postgraduate Students

  Graduation Name Degree Primary Supervisor
2013 Pol MacFhionnghaile PhD Y
2012 Jolanta Karpinska PhD Y
2016 Aoife Keegan Msc Y
2016 Ciaran O'Malley Msc Y
2015 Noel Byrne PhD Y
2011 Marian Vignoles Msc Y
2011 Fergal Coleman PhD Y

Modules Taught

  Term/Year Module Title Module Code Subject / Desc
3rd Science Inorganic Chemistry CH307
Postgraduate Chemical Research and problem Solving CH5103
4th Science Bioinorganic and Medicinal Chemistry CH4105-II/CH4108
Postgraduate Techniques and Skills for Chemistry Research CH5102
2nd Science Inorganic Chemistry CH204
3rd Science Experimental Chemistry I CH333
4th Science Inorganic Chemistry CH4105-I
3rd Science Analytical Chemistry and Molecular Structure CH326
3rd Science Computers in Chemistry Research CH3101

External Collaborators

  Name Organisation / Institute Country Description of Collaboration
Dr. Lozano-Pérez IMIDA, Murcia SPAIN
"We are pleased to announce a new collaboration agreement between Dr. Lozano-Pérez, IMIDA (Murcia, Spain) and Dr. Andrea Erxleben, NUI Galway, to use their Silk Fibroin Nanoparticles to encapsulate and deliver gold (I) complexes for cancer therapy."