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Biological and Chemical Sciences

Prof. Afshin Samali

B.Sc, Ph.D

Contact Details

Established Professor
School of Natural Sciences
NUI Galway
T: Ext. 2440
E: afshin.samali@nuigalway.ie
 
researcher
 

Biography

Professor Samali is a leading cancer biologist with expertise in the field of endoplasmic reticulum (ER) stress and cell death/survival signaling in cancer, with a successful research career spanning over 30 years. Prof. Samali and his team are working to understand the unfolded protein response (UPR), an adaptive signaling pathway induced by ER stress, with the goal of developing targeted anti-cancer therapies. Prof. Samali graduated with a B.Sc. in Biology from Maynooth University (NUIM) in 1993, followed by a Ph.D. in Biochemistry from University College Cork (UCC) in 1997. After a three-year postdoctoral fellowship at Karolinska Institute in Sweden (1997-2000), he was appointed as a lecturer in Department of Biochemistry at NUI Galway, becoming Professor of Biochemistry in 2007, and Professor and Chair of Cancer Biology in 2020. In 2010 he established the Apoptosis Research Centre (ARC) (www.apoptosis.ie) and he continues to serve as Director of ARC, which currently comprises 7 Principal Investigators and more than 40 research staff. Prof. Samali is also the co-founder of 3 spin-out companies and the Director of one of these companies, Cell Stress Discoveries Ltd. 

In 2014, Prof. Samali was awarded the “NUIG President’s award for Research Excellence- Research Supervisor of the Year”. He has supervised 33 Ph.D. students, 9 M.Sc. students and 23 post-doctoral researchers. To date, he has published over 160 peer-reviewed publications and currently has a h-index of 63, with over 28,000 citations. He has also filed 7 patent applications. He has been successful in obtaining over €23 million in competitive grant funding over the past 20 years for cell stress/cell death research, including EU (Horizon 2020), Higher Education Authority of Ireland, Enterprise Ireland, Health Research Board, Irish Cancer Society, Irish Research Council, Breast Cancer Now (previously Breast Cancer Campaign), and Industry, as well as being the recipient of a prestigious SFI Investigator Award (2006-2011). Prof. Samali is a member of European Cell Death Organisation (ECDO), Royal Academy of Medicine in Ireland (RAMI), Royal Irish Academy (MRIA) and co-founder of the Endoplasmic Reticulum Society. He is Editor of Int J Cell Biol, Senior Associate Editor of J Cell Mol Medicine (JCMM) and Review Editor for Frontiers in Cell and Developmental Biol (Cell Death and Cell Survival, Molecular and Cellular Oncology).


Research Interests

The main focus of my research is to understand the molecular mechanisms that control the cellular response to ER stress. ER stress causes unfolded proteins to accumulate in the ER and this activates a cellular signaling network called the Unfolded Protein Response (UPR). The UPR aims to reduce the load of unfolded proteins in the ER and restore ER homeostasis by a number of mechanisms, however, if the stress is too severe or prolonged the UPR can induce cell death. There are three ER transmembrane proteins, PERK, ATF6 and IRE1, involved in the initiation of downstream UPR signaling. ER stress and UPR have been implicated in the development of conditions such as neurodegenerative diseases, inflammatory disorders, diabetes and cancer. Currently my lab are studying (1) UPR signaling in tumorogenesis, tumor metastasis and therapy resistance; (2) UPR drug discovery, in particular drugs targeting IRE1 or PERK; (3) biomarker discovery as companion diagnostics and for stratification of patients based on UPR activation in tumors.

Research Projects

  Project Start Date End Date
Marion Maurel 01-JAN-16 31-JAN-16
Train Ers ITN 01-OCT-15 30-SEP-22
Inhibiting XBP1s production as a novel therapeutic strategy in Sepsis 01-APR-15 31-MAR-23
CURAM Aquila Bioscience limited 01-APR-15 19-APR-18
RESEARCH INNOVATION VOUCHER Aquila Bioscience Limited 09-MAR-15 08-MAR-16
Aaron Talty IRC Employment Based Postrgraduate Programme Afshin Samali 01-MAR-15 31-DEC-19
Targeting IRE1 in Disease 05-FEB-15 04-NOV-15
Eoghan McGrath IRC Employment Based Postrgraduate Programme Afshin Samali 01-FEB-15 30-SEP-17
CURAM Aquila Bioscience limited 01-JAN-15 31-DEC-20
ER Stress in Health and Disease 04-NOV-14 03-AUG-15
THE ROLE OF IRE1A/XBP-1S SIGNALLY IN THE PATHOGENESIS OF BREAST CANCER AFSHIN SAMALI 01-OCT-14 30-SEP-16
Understanding the role of the ER stress response in the aetiology of disease 08-SEP-14 07-JUN-16
MARIE CURIE ACTIONS ER STRESS IN HEALTH AND DISEASE A SAMALI 19-DEC-13 18-SEP-14
ER STRESS IN HEALTH AND DISEASE AFSHIN SAMALI 06-SEP-12 05-MAY-13
INTERUNIVERSITY ATTRACTION POLES PVII INTERNATIONAL PARTNERSHIP A SAMALI 01-APR-12 31-MAR-17
EI CS20120540 MARIE CURE ACTIONS TARGETING MULTIPROTEIN RECEPTOR AFSHIN SAMALI 30-MAR-12 30-NOV-13
CS/2011/375 FP7 PROPOSAL PREPARATION CO-ORDINATOR SUPPORT ENTERPRISE IRELAND PROF AFSHIN SAMALI 01-FEB-11 30-SEP-11
SFI OVERHEADS SALARY SUPPORT AFSHIN SAMALI 01-JAN-08 30-JUN-08
EI COMM PLUS CFTD 06 101 A SAMALI 01-DEC-06 30-APR-13
IRCSET EMBARK 2004 LORRAINE CUFFE SAMALI 01-OCT-04 30-APR-09
IRCSET JANICE REEVE AFSHIN SAMALI 01-OCT-02 11-FEB-09
EU TNF LIGAND RECEPTOR QLK3 2001 00498 SAMALI 01-JAN-02 26-NOV-07
PC20080340 Prof Afshin Samali Evaluation Targets o 01-FEB-09 31-MAR-12
SFI OVERHEADS EQUIPMENT AFSHIN SAMALI 01-JAN-08 31-DEC-08
IRCSET EMBARK 2007, MARIANNE VAN DIJK 01-OCT-07 28-FEB-12
SFI 09 SIRG B1575 AFSHIN SAMALI NOVEL RATIOMETRIC APPROACH TO IDENTIFY DECISIVE MOLECULAR 01-OCT-09 30-AUG-16
REGULATION IRE1 SIGNAL SFI 09/RFP/BIC2371 - A SAMALI 01-OCT-09 19-FEB-15
PRTLI3 BMES 2 2 01-JUL-02 28-JAN-08
989 MF 33 00 M EFFECTS OF HSP 01-JUL-00 29-NOV-04
HAEMATOLOGY RESEARCH FUND A SAMALI 15-MAY-06 14-MAY-13
SFI RFP 05 RFP BIC002 A SAMALI 01-MAY-06 30-APR-09
MF2003 MF 75 03 CARDIAC DISEASE A SAMALI 01-JAN-04 29-NOV-04
APOPTOSIS A SAMALI NCBES T SMITH 15-JAN-04 15-JAN-07
MF2004 MF65 04 DR. AFSHIN SAMALI 01-OCT-04 30-JUL-06
IHF GENE EXPRESSION SAMALI 01-SEP-01 31-DEC-04
TRIDENT EC STREP COORDINATION 01-OCT-06 30-SEP-09
10 YEAR CELEBRATION APOPTOSIS AFSHIN SAMALI 01-JUN-10 31-MAY-11
IRISH CANCER SOCIETY CRF09SZE AFSHIN SAMALI 01-DEC-09 30-JUN-13
MF2002 MF86 02 M MICHAEL O DWYER 01-DEC-02 29-NOV-04
EI CFTD 06 112 TRITAN A SAMALI 01-JUL-06 28-FEB-10
CANCER CARE WEST A SAMALI M O DWYER 01-JUL-06 30-SEP-09
TARGETING THE HSP72-IRE1 INTERACTION TO MODULATE THE UNFOLDED PROTEIN RESPONSE IN BREAST CANCER 2010NOVPR13 01-MAR-11 30-SEP-14
HAEMATOLOGY RESEARCH FUND A. SAMALI ORTHO BIOTECH 15-MAY-06 14-MAY-11
SFI ER STRESS-INDUCED APOPTOSIS AFSHIN SAMALI 31-MAR-06 31-MAR-10
CRI SECLECTIVE REGULATORS TRAIL A SAMALI 01-OCT-05 18-NOV-10
MILL FND MAJOR A SAMALI OX LDL INDUCED APOPTOSIS 01-NOV-01 15-OCT-09
ROLE IN DBP 1 IN BREAST CANCER DEVELOPMENT AND RESISTANCE TO THERAPY IRISH CANCER SOCIETY CRS11CLE AFSHIN SAMALI 01-OCT-11 31-MAR-15
IRISH CANCER SOC CRS10VIN A SAMALI 01-OCT-10 31-MAY-12
ENTERPRISE IRELAND FP7 PROPOSAL PREPARATION CO-ORDINATOR SUPPORT CS/2011/427 AFSHIN SAMALI 22-SEP-11 21-NOV-12
HRB HRA 2009 59 AFSHIN SAMALI 01-OCT-09 30-NOV-12
MF 81 2005 M A SAMALI M KEANE 01-OCT-05 30-APR-07
MF2003 MF99 03 M M O DWYER A SAMALI 01-APR-04 25-DEC-04
TRIDENT EC STREP INNOVATION PROJ AFSHIN SAMALI 01-OCT-06 30-SEP-09
APOPTOSIS SAMALI IND OVERHEADS N VAT 01-FEB-06 31-MAY-23
EI FEASIBILITY EVE IP 2006 413Y SAMALI 01-MAR-07 30-SEP-07
PRTLI3 BMES 2 3 01-JUL-02 12-MAY-08

Peer Reviewed Journals

  Year Publication
(2018) 'Repression of Mcl-1 expression by the CDC7/CDK9 inhibitor PHA-767491 overcomes bone marrow stroma-mediated drug resistance in AML'
E, O' Reilly and Dhami, S. P. S. and Baev, D. V. and Ortutay, C. and Halpin-McCormick, A. and Morrell, R. and Santocanale, C. and Samali, A. and Quinn, J. and O'Dwyer, M. E. and Szegezdi, E. (2018) 'Repression of Mcl-1 expression by the CDC7/CDK9 inhibitor PHA-767491 overcomes bone marrow stroma-mediated drug resistance in AML'. Sci Rep, 8 (1) [DOI] [Details]
(2020) 'Novel Pt(IV) prodrugs displaying antimitochondrial effects'
Tabrizi, L.; Thompson, K.; Mnich, K.; Chintha, C.; Gorman, A.; Morrison, L.; Luessing, J.; Lowndes, N.; Dockery, P.; Samali, A.; Erxleben, A. (2020) 'Novel Pt(IV) prodrugs displaying antimitochondrial effects'. Molecular Pharmaceutics, [Details]
(2020) 'Local intracerebral inhibition of IRE1 by MKC8866 sensitizes glioblastoma to irradiation/chemotherapy in vivo'
Le Reste, PJ;Pineau, R;Voutetakis, K;Samal, J;Jegou, G;Lhomond, S;Gorman, AM;Samali, A;Patterson, JB;Zeng, QP;Pandit, A;Aubry, M;Soriano, N;Etcheverry, A;Chatziioannou, A;Mosser, J;Avril, T;Chevet, E (2020) 'Local intracerebral inhibition of IRE1 by MKC8866 sensitizes glioblastoma to irradiation/chemotherapy in vivo'. Cancer Letters, 494 :73-83 [DOI] [Details]
(2020) 'Peptidomimetic-based identification of FDA-approved compounds inhibiting IRE1 activity'
Doultsinos, D;Carlesso, A;Chintha, C;Paton, JC;Paton, AW;Samali, A;Chevet, E;Eriksson, LA (2020) 'Peptidomimetic-based identification of FDA-approved compounds inhibiting IRE1 activity'. Febs Journal, [DOI] [Details]
(2020) 'Molecular modeling provides a structural basis for PERK inhibitor selectivity towards RIPK1'
Chintha, C;Carlesso, A;Gorman, AM;Samali, A;Eriksson, LA (2020) 'Molecular modeling provides a structural basis for PERK inhibitor selectivity towards RIPK1'. Rsc Advances, 10 :367-375 [DOI] [Details]
(2020) 'Molecular modeling provides a structural basis for PERK inhibitor selectivity towards RIPK1'
Chintha, C,Carlesso, A,Gorman, AM,Samali, A,Eriksson, LA (2020) 'Molecular modeling provides a structural basis for PERK inhibitor selectivity towards RIPK1'. Rsc Advances, 10 :367-375 [DOI] [Details]
(2020) 'The IRE1 and PERK arms of the unfolded protein response promote survival of rhabdomyosarcoma cells'
McCarthy, N;Dolgikh, N;Logue, S;Patterson, JB;Zeng, QP;Gorman, AM;Samali, A;Fulda, S (2020) 'The IRE1 and PERK arms of the unfolded protein response promote survival of rhabdomyosarcoma cells'. Cancer Letters, 490 :76-88 [DOI] [Details]
(2019) 'Control of anterior GRadient 2 (AGR2) dimerization links endoplasmic reticulum proteostasis to inflammation'
Maurel, M;Obacz, J;Avril, T;Ding, YP;Papadodima, O;Treton, X;Daniel, F;Pilalis, E;Horberg, J;Hou, WY;Beauchamp, MC;Tourneur-Marsille, J;Cazals-Hatem, D;Sommerova, L;Samali, A;Tavernier, J;Hrstka, R;Dupont, A;Fessart, D;Delom, F;Fernandez-Zapico, ME;Jansen, G;Eriksson, LA;Thomas, DY;Jerome-Majewska, L;Hupp, T;Chatziioannou, A;Chevet, E;Ogier-Denis, E (2019) 'Control of anterior GRadient 2 (AGR2) dimerization links endoplasmic reticulum proteostasis to inflammation'. Embo Molecular Medicine, 11 [DOI] [Details]
(2019) 'Merits and pitfalls of conventional and covalent docking in identifying new hydroxyl aryl aldehyde like compounds as human IRE1 inhibitors'
Carlesso, A,Chintha, C,Gorman, AM,Samali, A,Eriksson, LA (2019) 'Merits and pitfalls of conventional and covalent docking in identifying new hydroxyl aryl aldehyde like compounds as human IRE1 inhibitors'. Scientific Reports, 9 [DOI] [Details]
(2019) 'Inhibition of IRE1 alpha RNase activity reduces NLRP3 inflammasome assembly and processing of pro-IL1 beta'
Talty, A,Deegan, S,Ljujic, M,Mnich, K,Naicker, SD,Quandt, D,Zeng, QP,Patterson, JB,Gorman, AM,Griffin, MD,Samali, A,Logue, SE (2019) 'Inhibition of IRE1 alpha RNase activity reduces NLRP3 inflammasome assembly and processing of pro-IL1 beta'. Cell Death & Disease, 10 [DOI] [Details]
(2018) 'Dual IRE1 RNase functions dictate glioblastoma development'
Lhomond, S,Avril, T,Dejeans, N,Voutetakis, K,Doultsinos, D,McMahon, M,Pineau, R,Obacz, J,Papadodima, O,Jouan, F,Bourien, H,Logotheti, M,Jegou, G,Pallares-Lupon, N,Schmit, K,Le Reste, PJ,Etcheverry, A,Mosser, J,Barroso, K,Vauleon, E,Maurel, M,Samali, A,Patterson, JB,Pluquet, O,Hetz, C,Quillien, V,Chatziioannou, A,Chevet, E (2018) 'Dual IRE1 RNase functions dictate glioblastoma development'. Embo Molecular Medicine, 10 [DOI] [Details]
(2018) 'Dual IRE1 RNase functions dictate glioblastoma development'
Lhomond, S;Avril, T;Dejeans, N;Voutetakis, K;Doultsinos, D;McMahon, M;Pineau, R;Obacz, J;Papadodima, O;Jouan, F;Bourien, H;Logotheti, M;Jegou, G;Pallares-Lupon, N;Schmit, K;Le Reste, PJ;Etcheverry, A;Mosser, J;Barroso, K;Vauleon, E;Maurel, M;Samali, A;Patterson, JB;Pluquet, O;Hetz, C;Quillien, V;Chatziioannou, A;Chevet, E (2018) 'Dual IRE1 RNase functions dictate glioblastoma development'. Embo Molecular Medicine, 10 [DOI] [Details]
(2018) 'RIP2 enhances cell survival by activation of NF-kappa B in triple negative breast cancer cells'
Jaafar, R;Mnich, K;Dolan, S;Hillis, J;Almanza, A;Logue, SE;Samali, A;Gorman, AM (2018) 'RIP2 enhances cell survival by activation of NF-kappa B in triple negative breast cancer cells'. Biochemical And Biophysical Research Communications, 497 :115-121 [DOI] [Details]
(2018) 'Inhibition of IRE1 RNase activity modulates the tumor cell secretome and enhances response to chemotherapy'
Logue SE, McGrath EP, Cleary P, Greene S, Mnich K, Almanza A, Chevet E, Dwyer RM, Oommen A, Legembre P, Godey F, Madden EC, Leuzzi B, Obacz J, Zeng Q, Patterson JB, Jäger R, Gorman AM, Samali A (2018) 'Inhibition of IRE1 RNase activity modulates the tumor cell secretome and enhances response to chemotherapy'. Nature Communications, 9 [DOI] [Details]
(2018) 'Repression of Mcl-1 expression by the CDC7/CDK9 inhibitor PHA-767491 overcomes bone marrow stroma-mediated drug resistance in AML'
O'Reilly, E,Dhami, SPS,Baev, DV,Ortutay, C,Halpin-McCormick, A,Morrell, R,Santocanale, C,Samali, A,Quinn, J,O'Dwyer, ME,Szegezdi, E (2018) 'Repression of Mcl-1 expression by the CDC7/CDK9 inhibitor PHA-767491 overcomes bone marrow stroma-mediated drug resistance in AML'. Scientific Reports, 8 [DOI] [Details]
(2018) 'Autophagy and the unfolded protein response promote profibrotic effects of TGF-beta(1) in human lung fibroblasts'
Ghavami, S,Yeganeh, B,Zeki, AA,Shojaei, S,Kenyon, NJ,Ott, S,Samali, A,Patterson, J,Alizadeh, J,Moghadam, AR,Dixon, IMC,Unruh, H,Knight, DA,Post, M,Klonisch, T,Halayko, AJ (2018) 'Autophagy and the unfolded protein response promote profibrotic effects of TGF-beta(1) in human lung fibroblasts'. American Journal Of Physiology-Lung Cellular And Molecular Physiology, 314 :493-504 [DOI] [Details]
(2018) 'Generation of rationally-designed nerve growth factor (NGF) variants with receptor specificity'
Carleton, LA,Chakravarthy, R,van der Sloot, AM,Mnich, K,Serrano, L,Samali, A,Gorman, AM (2018) 'Generation of rationally-designed nerve growth factor (NGF) variants with receptor specificity'. Biochemical And Biophysical Research Communications, 495 :700-705 [DOI] [Details]
(2017) 'Homology model of the human tRNA splicing ligase RtcB'
Nandy, A,Saenz-Mendez, P,Gorman, AM,Samali, A,Eriksson, LA (2017) 'Homology model of the human tRNA splicing ligase RtcB'. Proteins, 85 :1983-1993 [DOI] [Details]
(2017) 'Generation of rationally-designed nerve growth factor (NGF) variants with receptor specificity'
Carleton LA, Chakravarthy R, van der Sloot AM, Mnich K, Serrano L, Samali A, Gorman AM. (2017) 'Generation of rationally-designed nerve growth factor (NGF) variants with receptor specificity'. Biochemical And Biophysical Research Communications, [DOI] [ARAN Link] [Details]
(2017) 'The ER Stress Sensor PERK Coordinates ER-Plasma Membrane Contact Site Formation through Interaction with Filamin-A and F-Actin Remodeling'
van Vliet, AR,Giordano, F,Gerlo, S,Segura, I,Van Eygen, S,Molenberghs, G,Rocha, S,Houcine, A,Derua, R,Verfaillie, T,Vangindertael, J,De Keersmaecker, H,Waelkens, E,Tavernier, J,Hofkens, J,Annaert, W,Carmeliet, P,Samali, A,Mizuno, H,Agostinis, P (2017) 'The ER Stress Sensor PERK Coordinates ER-Plasma Membrane Contact Site Formation through Interaction with Filamin-A and F-Actin Remodeling'. Molecular Cell, 65 [DOI] [Details]
(2017) 'HSPB1 facilitates ERK-mediated phosphorylation and degradation of BIM to attenuate endoplasmic reticulum stress-induced apoptosis'
Kennedy, D,Mnich, K,Oommen, D,Chakravarthy, R,Almeida-Souza, L,Krols, M,Saveljeva, S,Doyle, K,Gupta, S,Timmerman, V,Janssens, S,Gorman, AM,Samali, A (2017) 'HSPB1 facilitates ERK-mediated phosphorylation and degradation of BIM to attenuate endoplasmic reticulum stress-induced apoptosis'. Cell Death & Disease, 8 [DOI] [Details]
(2017) 'Experimental African trypanosome infection suppresses the development of multiple myeloma in mice by inducing intrinsic apoptosis of malignant plasma cells'
De Beule, N,Menu, E,Bertrand, MJM,Favreau, M,De Bruyne, E,Maes, K,De Veirman, K,Radwanska, M,Samali, A,Magez, S,Vanderkerken, K,De Trez, C (2017) 'Experimental African trypanosome infection suppresses the development of multiple myeloma in mice by inducing intrinsic apoptosis of malignant plasma cells'. Oncotarget, 8 :52016-52025 [DOI] [Details]
(2016) 'The pyrrolo-1,5-benzoxazepine, PBOX-15, enhances TRAIL-induced apoptosis by upregulation of DR5 and downregulation of core cell survival proteins in acute lymphoblastic leukaemia cells'
Nathwani, SM,Greene, LM,Butini, S,Campiani, G,Williams, DC,Samali, A,Szegezdi, E,Zisterer, DM (2016) 'The pyrrolo-1,5-benzoxazepine, PBOX-15, enhances TRAIL-induced apoptosis by upregulation of DR5 and downregulation of core cell survival proteins in acute lymphoblastic leukaemia cells'. International Journal Of Oncology, 49 :74-88 [DOI] [Details]
(2016) 'Targeting the angio-proteostasis network: Combining the forces against cancer'
Devisscher, L;Vieri, M;Logue, SE;Panse, J;Geerts, A;Van Vlierberghe, H;Chevet, E;Gorman, AM;Samali, A;Masouleh, BK (2016) 'Targeting the angio-proteostasis network: Combining the forces against cancer'. Pharmacology & Therapeutics, 167 :1-12 [DOI] [Details]
(2016) 'Endoplasmic reticulum stress-mediated induction of SESTRIN 2 potentiates cell survival'
Saveljeva S;Cleary P;Mnich K;Ayo A;Pakos-Zebrucka K;Patterson JB;Logue SE;Samali A; (2016) 'Endoplasmic reticulum stress-mediated induction of SESTRIN 2 potentiates cell survival'. Oncotarget, 7 (11) [DOI] [Details]
(2016) 'Endoplasmic reticulum stress-mediated induction of SESTRIN 2 potentiates cell survival'
Saveljeva, S,Cleary, P,Mnich, K,Ayo, A,Pakos-Zebrucka, K,Patterson, JB,Logue, SE,Samali, A (2016) 'Endoplasmic reticulum stress-mediated induction of SESTRIN 2 potentiates cell survival'. Oncotarget, 7 :12254-12266 [Details]
(2016) 'Deregulated expression of the HSP40 family members Auxilin-1 and -2 is indicative of proteostasis imbalance and predicts patient outcome in Ph+ leukemia'
Vieri, M,Geng, HM,Patterson, JB,Panse, J,Wilop, S,Samali, A,Chevet, E,Masouleh, BK (2016) 'Deregulated expression of the HSP40 family members Auxilin-1 and -2 is indicative of proteostasis imbalance and predicts patient outcome in Ph+ leukemia'. Experimental hematology & oncology, 5 [DOI] [Details]
(2016) 'Deregulated expression of the HSP40 family members Auxilin-1 and -2 is indicative of proteostasis imbalance and predicts patient outcome in Ph(+) leukemia'
Vieri M, Geng H;Patterson JB;Panse J;Wilop S;Samali A;Chevet E;Kharabi Masouleh B (2016) 'Deregulated expression of the HSP40 family members Auxilin-1 and -2 is indicative of proteostasis imbalance and predicts patient outcome in Ph(+) leukemia'. Experimental hematology & oncology, 5 [DOI] [Details]
(2016) 'Targeting the angio-proteostasis network: Combining the forces against cancer'
Devisscher L;Vieri M;Logue SE;Panse J;Geerts A;van Vlierberghe H;Chevet E;Gorman AM;Samali A;Kharabi Masouleh B; (2016) 'Targeting the angio-proteostasis network: Combining the forces against cancer'. Pharmacology & Therapeutics, [DOI] [Details]
(2016) 'The integrated stress response'
Pakos-Zebrucka K;Koryga I;Mnich K;Ljujic M;Samali A;Gorman AM; (2016) 'The integrated stress response'. Embo Reports, 17 (10) [DOI] [ARAN Link] [Details]
(2016) 'Decoy receptors block TRAIL sensitivity at a supracellular level: the role of stromal cells in controlling tumour TRAIL sensitivity'
O'Leary, L,van der Sloot, AM,Reis, CR,Deegan, S,Ryan, AE,Dhami, SPS,Murillo, LS,Cool, RH,de Sampaio, PC,Thompson, K,Murphy, G,Quax, WJ,Serrano, L,Samali, A,Szegezdi, E (2016) 'Decoy receptors block TRAIL sensitivity at a supracellular level: the role of stromal cells in controlling tumour TRAIL sensitivity'. Oncogene, 35 :1261-1270 [DOI] [Details]
(2016) 'Endoplasmic reticulum stress-mediated induction of SESTRIN 2 potentiates cell survival'
Saveljeva S, Cleary P;Mnich K;Ayo A;Pakos-Zebrucka K;Patterson JB;Logue SE;Samali A (2016) 'Endoplasmic reticulum stress-mediated induction of SESTRIN 2 potentiates cell survival'. Oncotarget, [DOI] [Details]
(2015) 'PERK regulated miR-424(322)-503 cluster fine-tunes activation of IRE1 and ATF6 during Unfolded Protein Response'
Gupta, A;Hossain, MM;Read, DE;Hetz, C;Samali, A;Gupta, S (2015) 'PERK regulated miR-424(322)-503 cluster fine-tunes activation of IRE1 and ATF6 during Unfolded Protein Response'. Scientific Reports, 5 [DOI] [Details]
(2015) 'PERK regulated miR-424(322)-503 cluster fine-tunes activation of IRE1 and ATF6 during Unfolded Protein Response'
Gupta, A,Hossain, MM,Read, DE,Hetz, C,Samali, A,Gupta, S (2015) 'PERK regulated miR-424(322)-503 cluster fine-tunes activation of IRE1 and ATF6 during Unfolded Protein Response'. Scientific Reports, 5 [DOI] [Details]
(2015) 'Endoplasmic reticulum stress-activated cell reprogramming in oncogenesis'
Chevet E, Hetz C;Samali A (2015) 'Endoplasmic reticulum stress-activated cell reprogramming in oncogenesis'. Cancer Discovery, 5 (6):586-597 [DOI] [Details]
(2015) 'Hepatitis B and C virus-induced hepatitis: Apoptosis, autophagy, and unfolded protein response'
Yeganeh B, Rezaei Moghadam A;Alizadeh J;Wiechec E;Alavian SM;Hashemi M;Geramizadeh B;Samali A;Bagheri Lankarani K;Post M;Peymani P;Coombs KM;Ghavami S (2015) 'Hepatitis B and C virus-induced hepatitis: Apoptosis, autophagy, and unfolded protein response'. World Journal Of Gastroenterology, 21 (47):13225-13239 [DOI] [Details]
(2015) 'Drugging the unfolded protein response in acute leukemias'
Kharabi Masouleh B, Chevet E;Panse J;Jost E;O'Dwyer M;Bruemmendorf TH;Samali A (2015) 'Drugging the unfolded protein response in acute leukemias'. Journal Of Hematology & Oncology, 8 [DOI] [Details]
(2015) 'Methods for Studying ER Stress and UPR Markers in Human Cells'
Kennedy, D;Samali, A;Jager, R (2015) 'Methods for Studying ER Stress and UPR Markers in Human Cells'. Methods in Molecular Biology, 1292 :3-18 [DOI] [Details]
(2015) 'Endoplasmic reticulum stress induces ligand-independent TNFR1-mediated necroptosis in L929 cells'
Saveljeva, S,Mc Laughlin, SL,Vandenabeele, P,Samali, A,Bertrand, MJM (2015) 'Endoplasmic reticulum stress induces ligand-independent TNFR1-mediated necroptosis in L929 cells'. Cell Death & Disease, 6 [DOI] [ARAN Link] [Details]
(2015) 'A close connection between the PERK and IRE arms of the UPR and the transcriptional regulation of autophagy'
Deegan, S,Koryga, I,Glynn, SA,Gupta, S,Gorman, AM,Samali, A (2015) 'A close connection between the PERK and IRE arms of the UPR and the transcriptional regulation of autophagy'. Biochemical And Biophysical Research Communications, 456 :305-311 [DOI] [Details]
(2015) 'Decorated Macrocycles via Ring-Closing Double-Reductive Amination. Identification of an Apoptosis Inducer of Leukemic Cells That at Least Partially Antagonizes a 5-HT2 Receptor'
Zhou, J,Reidy, M,O'Reilly, C,Jarikote, DV,Negi, A,Samali, A,Szegezdi, E,Murphy, PV (2015) 'Decorated Macrocycles via Ring-Closing Double-Reductive Amination. Identification of an Apoptosis Inducer of Leukemic Cells That at Least Partially Antagonizes a 5-HT2 Receptor'. Organic Letters, 17 :1672-1675 [DOI] [ARAN Link] [Details]
(2015) 'G2/M Arrest Sensitises Erythroid Leukemia Cells to TRAIL-induced Apoptosis'
Séverine Cruet-Hennequart; Tanja Paavilainen; Michael O’Dwyer; Réka Tóth; Michael P Carty; Afshin Samali; Eva Szegezdi (2015) 'G2/M Arrest Sensitises Erythroid Leukemia Cells to TRAIL-induced Apoptosis'. Journal of Leukemia, 4 [DOI] [Details]
(2015) 'Methods for Studying ER Stress and UPR Markers in Human Cells'
Kennedy, D,Samali, A,Jager, R,Oslowski, CM (2015) 'Methods for Studying ER Stress and UPR Markers in Human Cells'. Methods Mol Biol, 1292 :3-18 [DOI] [Details]
(2015) 'BCL-2 modulates the unfolded protein response by enhancing splicing of X-box binding protein-1'
Chonghaile TN, Gupta S;John M;Szegezdi E;Logue SE;Samali A (2015) 'BCL-2 modulates the unfolded protein response by enhancing splicing of X-box binding protein-1'. Biochem. Biophys. Res. Commun, 466 (1):40-45 [DOI] [Details]
(2015) 'G2/M arrest sensitises erythroid leukemia cells to TRAIL-induced apoptosis'
Cruet-Hennequart, S, Paavilainen T, O'Dwyer, M, Toth R, Carty, MP, Samali, A, Szegezdi, E (2015) 'G2/M arrest sensitises erythroid leukemia cells to TRAIL-induced apoptosis'. Journal of Leukemia, [Details]
(2015) 'BCL-2 modulates the unfolded protein response by enhancing splicing of X-box binding protein-1'
Chonghaile, TN,Gupta, S,John, M,Szegezdi, E,Logue, SE,Samali, A (2015) 'BCL-2 modulates the unfolded protein response by enhancing splicing of X-box binding protein-1'. Biochemical And Biophysical Research Communications, 466 :40-45 [DOI] [Details]
(2015) 'BCL-2 modulates the unfolded protein response by enhancing splicing of X-box binding protein-1'
Chonghaile TN;Gupta S;John M;Szegezdi E;Logue SE;Samali A; (2015) 'BCL-2 modulates the unfolded protein response by enhancing splicing of X-box binding protein-1'. Biochemical And Biophysical Research Communications, 466 (1) [DOI] [Details]
(2014) 'Stressed to death - mechanisms of ER stress-induced cell death'
Sovolyova N;Healy S;Samali A;Logue SE; (2014) 'Stressed to death - mechanisms of ER stress-induced cell death'. Journal Of Biological Chemistry, 395 (1) [DOI] [Details]
(2014) 'Deficiency in the mitochondrial apoptotic pathway reveals the toxic potential of autophagy under ER stress conditions'
Deegan S;Saveljeva S;Logue SE;Pakos-Zebrucka K;Gupta S;Vandenabeele P;Bertrand MJ;Samali A; (2014) 'Deficiency in the mitochondrial apoptotic pathway reveals the toxic potential of autophagy under ER stress conditions'. Autophagy, 10 (11) [DOI] [Details]
(2014) 'Mechanisms of Resistance to Cell Death Pathways in Cancer Cells'
Samali, A;Jager, R (2014) 'Mechanisms of Resistance to Cell Death Pathways in Cancer Cells'. Pathobiology Of Human Disease: A Dynamic Encyclopedia Of Disease Mechanisms, :393-402 [DOI] [Details]
(2014) 'Mechanisms of Resistance to Cell Death Pathways in Cancer Cells'
Samali, A,Jager, R,McManus, LM,Mitchell, RN (2014) 'Mechanisms of Resistance to Cell Death Pathways in Cancer Cells'. Pathobiology Of Human Disease: A Dynamic Encyclopedia Of Disease Mechanisms, :393-402 [DOI] [Details]
(2014) 'Stressed to death - mechanisms of ER stress-induced cell death'
Sovolyova, N,Healy, S,Samali, A,Logue, SE (2014) 'Stressed to death - mechanisms of ER stress-induced cell death'. Biological Chemistry, 395 (1):1-13 [DOI] [Details]
(2014) 'miRNA signature of unfolded protein response in H9c2 rat cardiomyoblasts'
Read, DE,Gupta, A,Ladilov, Y,Samali, A,Gupta, S (2014) 'miRNA signature of unfolded protein response in H9c2 rat cardiomyoblasts'. Cell And Bioscience, 4 [DOI] [ARAN Link] [Details]
(2014) 'RIPK1 promotes death receptor-independent caspase-8-mediated apoptosis under unresolved ER stress conditions'
Estornes, Y,Aguileta, MA,Dubuisson, C,De Keyser, J,Goossens, V,Kersse, K,Samali, A,Vandenabeele, P,Bertrand, MJM (2014) 'RIPK1 promotes death receptor-independent caspase-8-mediated apoptosis under unresolved ER stress conditions'. Cell Death & Disease, 5 [DOI] [Details]
(2014) 'Deficiency in the mitochondrial apoptotic pathway reveals the toxic potential of autophagy under ER stress conditions'
Deegan S, Saveljeva S;Logue SE;Pakos-Zebrucka K;Gupta S;Vandenabeele P;Bertrand MJ;Samali A (2014) 'Deficiency in the mitochondrial apoptotic pathway reveals the toxic potential of autophagy under ER stress conditions'. Autophagy, 10 (11):1921-1936 [DOI] [Details]
(2014) 'miRNA signature of unfolded protein response in H9c2 rat cardiomyoblasts'
Read DE, Gupta A;Ladilov Y;Samali A;Gupta S (2014) 'miRNA signature of unfolded protein response in H9c2 rat cardiomyoblasts'. Cell And Bioscience, 4 (1) [DOI] [Details]
(2014) 'Deficiency in the mitochondrial apoptotic pathway reveals the toxic potential of autophagy under ER stress conditions'
Deegan, S,Saveljeva, S,Logue, SE,Pakos-Zebrucka, K,Gupta, S,Vandenabeele, P,Bertrand, MJM,Samali, A (2014) 'Deficiency in the mitochondrial apoptotic pathway reveals the toxic potential of autophagy under ER stress conditions'. Autophagy, 10 :1921-1936 [DOI] [Details]
(2014) 'ER stress responses in the absence of apoptosome: A comparative study in CASP9 proficient vs deficient mouse embryonic fibroblasts'
Deegan, S,Saveljeva, S,Gupta, S,MacDonald, DC,Samali, A (2014) 'ER stress responses in the absence of apoptosome: A comparative study in CASP9 proficient vs deficient mouse embryonic fibroblasts'. Biochemical And Biophysical Research Communications, 451 :367-373 [DOI] [Details]
(2014) 'Heat shock preconditioning protects against ER stress-induced apoptosis through the regulation of the BH3-only protein BIM'
Kennedy, D,Mnich, K,Samali, A (2014) 'Heat shock preconditioning protects against ER stress-induced apoptosis through the regulation of the BH3-only protein BIM'. FEBS open bio, 4 :813-821 [DOI] [Details]
(2014) 'Nerve growth factor-mediated inhibition of apoptosis post-caspase activation is due to removal of active caspase-3 in a lysosome-dependent manner'
Mnich, K,Carleton, LA,Kavanagh, ET,Doyle, KM,Samali, A,Gorman, AM (2014) 'Nerve growth factor-mediated inhibition of apoptosis post-caspase activation is due to removal of active caspase-3 in a lysosome-dependent manner'. Cell Death & Disease, 5 [DOI] [ARAN Link] [Details]
(2013) 'New directions in ER stress-induced cell death'
Logue SE;Cleary P;Saveljeva S;Samali A; (2013) 'New directions in ER stress-induced cell death'. Apoptosis : An International Journal On Programmed Cell Death, 18 (5) [DOI] [Details]
(2013) 'Pro-apoptotic signaling induced by photo-oxidative ER stress is amplified by Noxa, not Bim'
Verfaillie, T,van Vliet, A,Garg, AD,Dewaele, M,Rubio, N,Gupta, S,de Witte, P,Samali, A,Agostinis, P (2013) 'Pro-apoptotic signaling induced by photo-oxidative ER stress is amplified by Noxa, not Bim'. Biochemical And Biophysical Research Communications, 438 :500-506 [DOI] [Details]
(2013) 'Current concepts in ER stress-induced apoptosis'
13. Logue SE, Gorman AM, Cleary P, Keogh N, Samali A (2013) 'Current concepts in ER stress-induced apoptosis'. Journal of Carcinogenesis & Mutagenesis, S6 :1-7 [DOI] [Details]
(2013) 'Structural determinants of DISC function: New insights into death receptor-mediated apoptosis signalling'
Sessler, T,Healy, S,Samali, A,Szegezdi, E (2013) 'Structural determinants of DISC function: New insights into death receptor-mediated apoptosis signalling'. Pharmacology & Therapeutics, 140 (2):186-199 [DOI] [Details]
(2013) 'The eIF2α kinases: their structures and functions'
Donnelly N, Gorman AM, Gupta S, Samali A (2013) 'The eIF2α kinases: their structures and functions'. Cellular And Molecular Life Sciences, 70 (19):3493-3511 [DOI] [Details]
(2013) 'Endoplasmic Reticulum Stress and the Unfolded Protein Response: Targeting the Achilles Heel of Multiple Myeloma'
Vincenz, L,Jager, R,O'Dwyer, M,Samali, A (2013) 'Endoplasmic Reticulum Stress and the Unfolded Protein Response: Targeting the Achilles Heel of Multiple Myeloma'. Molecular Cancer Therapeutics, 12 (6):831-843 [DOI] [Details]
(2013) 'Resistance to TRAIL in non-transformed cells is due to multiple redundant pathways'
van Dijk, M,Halpin-McCormick, A,Sessler, T,Samali, A,Szegezdi, E (2013) 'Resistance to TRAIL in non-transformed cells is due to multiple redundant pathways'. Cell Death & Disease, 4 [DOI] [ARAN Link] [Details]
(2013) 'The eIF2 alpha kinases: their structures and functions'
Donnelly, N,Gorman, AM,Gupta, S,Samali, A (2013) 'The eIF2 alpha kinases: their structures and functions'. Cell Mol Life Sci, 70 :3493-3511 [DOI] [Details]
(2013) 'Disruption of microRNA Biogenesis Confers Resistance to ER Stress-Induced Cell Death Upstream of the Mitochondrion'
Cawley, K,Logue, SE,Gorman, AM,Zeng, QP,Patterson, J,Gupta, S,Samali, A (2013) 'Disruption of microRNA Biogenesis Confers Resistance to ER Stress-Induced Cell Death Upstream of the Mitochondrion'. Plos One, 8 [DOI] [ARAN Link] [Details]
(2013) 'Atypical heat shock response and acquisition of thermotolerance in P388D1 cells'
Oommen, D,Giricz, Z,Srinivas, UK,Samali, A (2013) 'Atypical heat shock response and acquisition of thermotolerance in P388D1 cells'. Biochemical And Biophysical Research Communications, 430 :236-240 [DOI] [Details]
(2013) 'Pro-apoptotic signaling induced by photo-oxidative ER stress is amplified by Noxa, not Bim'
Verfaillie T, van Vliet A, Garg AD, Dewaele M, Rubio N, Gupta S, de Witte P, Samali A, Agostinis P (2013) 'Pro-apoptotic signaling induced by photo-oxidative ER stress is amplified by Noxa, not Bim'. Biochem, 438 (3):500-506 [DOI] [Details]
(2013) 'Resistance to TRAIL in non-transformed cells is due to multiple redundant pathways'
van Dijk M, Halpin-McCormick A, Sessler T, Samali A, Szegezdi E (2013) 'Resistance to TRAIL in non-transformed cells is due to multiple redundant pathways'. Cell, 4 [DOI] [Details]
(2013) 'New directions in ER stress-induced cell death'
Logue SE, Cleary P, Saveljeva S, Samali A (2013) 'New directions in ER stress-induced cell death'. Apoptosis, 18 (5):537-546 [DOI] [Details]
(2013) 'Stress-induced self-cannibalism: on the regulation of autophagy by endoplasmic reticulum stress'
Deegan S, Saveljeva S, Gorman AM, Samali A (2013) 'Stress-induced self-cannibalism: on the regulation of autophagy by endoplasmic reticulum stress'. Cellular And Molecular Life Sciences, 70 (14):2425-2441 [DOI] [Details]
(2013) 'New directions in ER stress-induced cell death'
Logue, SE,Cleary, P,Saveljeva, S,Samali, A (2013) 'New directions in ER stress-induced cell death'. Apoptosis, 18 :537-546 [DOI] [Details]
(2013) 'Stress-induced self-cannibalism: on the regulation of autophagy by endoplasmic reticulum stress'
Deegan, S,Saveljeva, S,Gorman, AM,Samali, A (2013) 'Stress-induced self-cannibalism: on the regulation of autophagy by endoplasmic reticulum stress'. Cell Mol Life Sci, 70 :2425-2441 [DOI] [Details]
(2013) 'Disruption of microRNA biogenesis confers resistance to ER stress-induced cell death upstream of the mitochondrion'
Cawley K;Logue SE;Gorman AM;Zeng Q;Patterson J;Gupta S;Samali A; (2013) 'Disruption of microRNA biogenesis confers resistance to ER stress-induced cell death upstream of the mitochondrion'. Plos One, 8 (8) [DOI] [Details]
(2012) 'Kinetics in Signal Transduction Pathways Involving Promiscuous Oligomerizing Receptors Can Be Determined by Receptor Specificity: Apoptosis Induction by TRAIL'
Szegezdi, E;van der Sloot, AM;Mahalingam, D;O'Leary, L;Cool, RH;Munoz, IG;Montoya, G;Quax, WJ;de Jong, S;Samali, A;Serrano, L (2012) 'Kinetics in Signal Transduction Pathways Involving Promiscuous Oligomerizing Receptors Can Be Determined by Receptor Specificity: Apoptosis Induction by TRAIL'. Molecular & Cellular Proteomics, 11 [DOI] [Details]
(2012) 'The unfolded protein response at the crossroads of cellular life and death during ER stress'
Jäger, R; Bertrand, MJ; Gorman, AM; Vandenabeele, P; Samali, A (2012) 'The unfolded protein response at the crossroads of cellular life and death during ER stress'. Biology of the Cell, [Details]
(2012) 'The unfolded protein response at the crossroads of cellular life and death during ER stress'
Jäger R, Bertrand MJM, Gorman AM, Vandenabeele P, Samali A (2012) 'The unfolded protein response at the crossroads of cellular life and death during ER stress'. Biology of the Cell, [DOI] [Details]
(2012) 'Perk-dependent repression of miR-106b-25 cluster is required for ER stress-induced apoptosis'
Gupta, S,Read, DE,Deepti, A,Cawley, K,Gupta, A,Oommen, D,Verfaillie, T,Matus, S,Smith, MA,Mott, JL,Agostinis, P,Hetz, C,Samali, A (2012) 'Perk-dependent repression of miR-106b-25 cluster is required for ER stress-induced apoptosis'. Cell Death & Disease, 3 [DOI] [Details]
(2012) 'Kinetics in Signal Transduction Pathways Involving Promiscuous Oligomerizing Receptors Can Be Determined by Receptor Specificity: Apoptosis Induction by TRAIL'
Szegezdi, E,van der Sloot, AM,Mahalingam, D,O'Leary, L,Cool, RH,Munoz, IG,Montoya, G,Quax, WJ,de Jong, S,Samali, A,Serrano, L (2012) 'Kinetics in Signal Transduction Pathways Involving Promiscuous Oligomerizing Receptors Can Be Determined by Receptor Specificity: Apoptosis Induction by TRAIL'. Molecular & Cellular Proteomics, 11 [DOI] [Details]
(2012) 'PERK is required at the ER-mitochondrial contact sites to convey apoptosis after ROS-based ER stress'
Verfaillie, T,Rubio, N,Garg, AD,Bultynck, G,Rizzuto, R,Decuypere, JP,Piette, J,Linehan, C,Gupta, S,Samali, A,Agostinis, P (2012) 'PERK is required at the ER-mitochondrial contact sites to convey apoptosis after ROS-based ER stress'. Cell Death And Differentiation, 19 :1880-1891 [DOI] [Details]
(2012) 'NOXA contributes to the sensitivity of PERK-deficient cells to ER stress'
Gupta, S,Giricz, Z,Natoni, A,Donnelly, N,Deegan, S,Szegezdi, E,Samali, A (2012) 'NOXA contributes to the sensitivity of PERK-deficient cells to ER stress'. Febs Letters, 586 :4023-4030 [DOI] [Details]
(2012) 'Bisphenol A-Mediated Suppression of LPL Gene Expression Inhibits Triglyceride Accumulation during Adipogenic Differentiation of Human Adult Stem Cells'
Chris Linehan, Sanjeev Gupta, Afshin Samali, Lynn O’Connor (2012) 'Bisphenol A-Mediated Suppression of LPL Gene Expression Inhibits Triglyceride Accumulation during Adipogenic Differentiation of Human Adult Stem Cells'. Plos One, [ARAN Link] [Details]
(2012) 'NOXA contributes to the sensitivity of PERK-deficient cells to ER stress'
Gupta S, Giricz Z, Natoni A, Donnelly N, Deegan S, Szegezdi E, Samali A (2012) 'NOXA contributes to the sensitivity of PERK-deficient cells to ER stress'. Febs Letters, 586 (22):4023-4030 [DOI] [Details]
(2012) 'Impairment of endoplasmic reticulum in liver as an early consequence of the systemic inflammatory response in rats'
Nürnberger S, Miller I, Duvigneau JC, Kavanagh ET, Gupta S, Hartl RT, Hori O, Gesslbauer B, Samali A, Kungl A, Redl H, Kozlov AV (2012) 'Impairment of endoplasmic reticulum in liver as an early consequence of the systemic inflammatory response in rats'. American Journal Of Physics, 303 (12):1-83 [DOI] [Details]
(2012) 'Stress management at the ER: regulators of ER stress-induced apoptosis'
Gorman AM, Healy SJ, Jäger R, Samali A (2012) 'Stress management at the ER: regulators of ER stress-induced apoptosis'. Pharmacology & therapeutics, 134 (3):306-316 [DOI] [ARAN Link] [Details]
(2012) 'The unfolded protein response at the crossroads of cellular life and death during endoplasmic reticulum stress'
Jäger R, Bertrand MJ, Gorman AM, Vandenabeele P, Samali A (2012) 'The unfolded protein response at the crossroads of cellular life and death during endoplasmic reticulum stress'. Biology of the Cell, 104 (5):259-270 [DOI] [Details]
(2012) 'Impairment of endoplasmic reticulum in liver as an early consequence of the systemic inflammatory response in rats'
Nurnberger, S,Miller, I,Duvigneau, JC,Kavanagh, ET,Gupta, S,Hartl, RT,Hori, O,Gesslbauer, B,Samali, A,Kungl, A,Redl, H,Kozlov, AV (2012) 'Impairment of endoplasmic reticulum in liver as an early consequence of the systemic inflammatory response in rats'. American Journal Of Physiology-Gastrointestinal And Liver Physiology, 303 :1373-1383 [DOI] [Details]
(2011) 'Mechanisms of Action of a Dual Cdc7/Cdk9 Kinase Inhibitor against Quiescent and Proliferating CLL Cells'
Natoni, A;Murillo, LS;Kliszczak, AE;Catherwood, MA;Montagnoli, A;Samali, A;O'Dwyer, M;Santocanale, C (2011) 'Mechanisms of Action of a Dual Cdc7/Cdk9 Kinase Inhibitor against Quiescent and Proliferating CLL Cells'. Molecular Cancer Therapeutics, 10 :1624-1634 [DOI] [Details]
(2011) 'ASSAYS FOR DETECTING THE UNFOLDED PROTEIN RESPONSE'
Cawley, K;Deegan, S;Samali, A;Gupta, S (2011) 'ASSAYS FOR DETECTING THE UNFOLDED PROTEIN RESPONSE'. Methods In Enzymology: Unfolded Protein Response And Cellular Stress, Vol 490, Pt B, 490 :31-51 [DOI] [Details]
(2011) 'Assays for detecting the unfolded protein response'
Cawley K, Deegan S, Samali A, Gupta S. (2011) 'Assays for detecting the unfolded protein response'. Methods Enzymol, 490 :31-51 [Details]
(2011) 'The Proteasome Inhibitor Bortezomib Sensitizes AML with Myelomonocytic'
Van Dijk M, Murphy E, Morrell R, Knapper S, O'Dwyer M, Samali A and Szegezdi E. (2011) 'The Proteasome Inhibitor Bortezomib Sensitizes AML with Myelomonocytic'. Differentiation to TRAIL Mediated Apoptosis Cancers, 3 (1):1329-1350 [DOI] [Details]
(2011) 'An unfractionated fucoidan from Ascophyllum nodosum: extraction, characterization, and apoptotic effects in vitro'
Foley SA, Szegezdi E, Mulloy B, Samali A, Tuohy MG (2011) 'An unfractionated fucoidan from Ascophyllum nodosum: extraction, characterization, and apoptotic effects in vitro'. Journal Of Natural Products, 74 (9):1851-1861 [DOI] [Details]
(2011) 'The Proteasome Inhibitor Bortezomib Sensitizes AML with Myelomonocytic Differentiation to TRAIL Mediated Apoptosis'
van Dijk M, Murphy E, Morrell M , Knapper S , O'Dwyer M, Samali A, Eva Szegezdi E. (2011) 'The Proteasome Inhibitor Bortezomib Sensitizes AML with Myelomonocytic Differentiation to TRAIL Mediated Apoptosis'. Cancers, 3 :1329-1350 [ARAN Link] [Details]
(2011) 'Mechanisms of Action of a Dual Cdc7/Cdk9 Kinase Inhibitor against Quiescent and Proliferating CLL Cells'
Natoni, A,Murillo, LS,Kliszczak, AE,Catherwood, MA,Montagnoli, A,Samali, A,O'Dwyer, M,Santocanale, C (2011) 'Mechanisms of Action of a Dual Cdc7/Cdk9 Kinase Inhibitor against Quiescent and Proliferating CLL Cells'. Molecular Cancer Therapeutics, 10 :1624-1634 [DOI] [ARAN Link] [Details]
(2011) 'Targeting AML through DR4 with a novel variant of rhTRAIL'
Szegezdi, E,Reis, CR,van der Sloot, AM,Natoni, A,O'Reilly, A,Reeve, J,Cool, RH,O'Dwyer, M,Knapper, S,Serrano, L,Quax, WJ,Samali, A (2011) 'Targeting AML through DR4 with a novel variant of rhTRAIL'. Journal Of Cellular And Molecular Medicine, 15 :2216-2231 [DOI] [Details]
(2011) 'Unfolded proteins and endoplasmic reticulum stress in neurodegenerative disorders'
Doyle, K.M., Kennedy, D., Gorman, A.M., Gupta, S., Healy, S.J.M., Samali, A. (2011) 'Unfolded proteins and endoplasmic reticulum stress in neurodegenerative disorders'. Journal of Cellular and Molecular Medicine, 15 (10):2025-2039 [Details]
(2010) 'Mechanisms of ER Stress-Mediated Mitochondrial Membrane Permeabilization'
Gupta S;Cuffe L;Szegezdi E;Logue SE;Neary C;Healy S;Samali A; (2010) 'Mechanisms of ER Stress-Mediated Mitochondrial Membrane Permeabilization'. International Journal Of Cell Biology, 2010 [DOI] [Details]
(2010) 'Cell stress and cell death'
Samali A, Fulda S, Gorman AM, Hori O, Srinivasula SM. (2010) 'Cell stress and cell death'. Int J Cell Biol, 2010 :245803-2pp [Details]
(2010) 'HSP72 Protects Cells from ER Stress-induced Apoptosis via Enhancement of IRE1 alpha-XBP1 Signaling through a Physical Interaction'
Gupta, S,Deepti, A,Deegan, S,Lisbona, F,Hetz, C,Samali, A (2010) 'HSP72 Protects Cells from ER Stress-induced Apoptosis via Enhancement of IRE1 alpha-XBP1 Signaling through a Physical Interaction'. Plos Biology, 8 [DOI] [Details]
(2010) 'Rapid and efficient cancer cell killing mediated by high-affinity death receptor homotrimerizing TRAIL variants'
Reis, CR,van der Sloot, AM,Natoni, A,Szegezdi, E,Setroikromo, R,Meijer, M,Sjollema, K,Stricher, F,Cool, RH,Samali, A,Serrano, L,Quax, WJ (2010) 'Rapid and efficient cancer cell killing mediated by high-affinity death receptor homotrimerizing TRAIL variants'. Cell Death & Disease, 1 [DOI] [Details]
(2010) 'Mechanisms of ER Stress-Mediated Mitochondrial Membrane Permeabilization.010; PubMed Central PMCID: PMC2821636'
Gupta S, Cuffe L, Szegezdi E, Logue SE, Neary C, Healy S, Samali A. (2010) 'Mechanisms of ER Stress-Mediated Mitochondrial Membrane Permeabilization.010; PubMed Central PMCID: PMC2821636'. Int J Cell Biol, [ARAN Link] [Details]
(2010) 'Synthetic constrained peptide selectively binds and antagonizes death receptor 5'
Vrielink, J,Heins, MS,Setroikromo, R,Szegezdi, E,Mullally, MM,Samali, A,Quax, WJ (2010) 'Synthetic constrained peptide selectively binds and antagonizes death receptor 5'. Febs Journal, 277 :1653-1665 [DOI] [Details]
(2010) 'Regulation of NF-kB responses by epigenetic suppression of IkBa expression in HCT116 intestinal epithelial cells'
Plantivaux A, Szegezdi E, Samali A, Egan L. (2010) 'Regulation of NF-kB responses by epigenetic suppression of IkBa expression in HCT116 intestinal epithelial cells'. American Journal Of Physiology: Gastrointestinal And Liver Physiology, 299 (1):96-105 [DOI] [Details]
(2010) 'Cellular Stress Responses: cell survival and cell death'
Fulda S, Gorman AM, Hori O, Samali A. (2010) 'Cellular Stress Responses: cell survival and cell death'. Int J Cell Biol, [DOI] [Details]
(2010) 'Methods for Monitoring Endoplasmic Reticulum Stress and the Unfolded Protein Response'
Samali, A., Fitzgerald, U., Deegan, S., & Gupta, S. (2010) 'Methods for Monitoring Endoplasmic Reticulum Stress and the Unfolded Protein Response'. International Journal Of Cell Biology, [ARAN Link] [Details]
(2010) 'Early growth response-1 is a regulator of DR5-induced apoptosis in colon cancer cells'
Mahalingam, D,Natoni, A,Keane, M,Samali, A,Szegezdi, E (2010) 'Early growth response-1 is a regulator of DR5-induced apoptosis in colon cancer cells'. British Journal Of Cancer, 102 :754-764 [DOI] [Details]
(2009) 'Elevation of cAMP in Mesenchymal Stem Cells Transiently Upregulates Neural Markers Rather than Inducing Neural Differentiation'
Rooney, GE,Howard, L,O'Brien, T,Windebank, AJ,Barry, FP (2009) 'Elevation of cAMP in Mesenchymal Stem Cells Transiently Upregulates Neural Markers Rather than Inducing Neural Differentiation'. Stem Cells And Development, 18 :387-398 [DOI] [Details]
(2009) 'Stem cells are resistant to TRAIL receptor-mediated apoptosis'
Szegezdi, E,O'Reilly, A,Davy, Y,Vawda, R,Taylor, DL,Murphy, M,Samali, A,Mehmet, H (2009) 'Stem cells are resistant to TRAIL receptor-mediated apoptosis'. Journal Of Cellular And Molecular Medicine, 13 :4409-4414 [DOI] [Details]
(2009) 'Differential activation of JNK1 isoforms by TRAIL receptors modulate apoptosis of colon cancer cell lines'
Mahalingam, D,Keane, M,Pirianov, G,Mehmet, H,Samali, A,Szegezdi, E (2009) 'Differential activation of JNK1 isoforms by TRAIL receptors modulate apoptosis of colon cancer cell lines'. British Journal Of Cancer, 100 :1415-1424 [DOI] [Details]
(2009) 'Enhancement of Antitumor Properties of rhTRAIL by Affinity Increase Toward its Death Receptors'
Reis, CR,van der Sloot, AM,Szegezdi, E,Natoni, A,Tur, V,Cool, RH,Samali, A,Serrano, L,Quax, WJ (2009) 'Enhancement of Antitumor Properties of rhTRAIL by Affinity Increase Toward its Death Receptors'. Biochemistry, 48 :2180-2191 [DOI] [Details]
(2009) 'Is there a role for nuclear factor kappaB in tumor necrosis factor-related apoptosis-inducing ligand resistance?'
Plantivaux A, Szegezdi E, Samali A, Egan L (2009) 'Is there a role for nuclear factor kappaB in tumor necrosis factor-related apoptosis-inducing ligand resistance?'. Annals of the New York Academy of Sciences, 1171 :38-49 [DOI] [Details]
(2009) 'Enhanced Antitumor Efficacy of a DR5-Specific TRAIL Variant over Recombinant Human TRAIL in a Bioluminescent Ovarian Cancer Xenograft Model'
Duiker, EW,de Vries, EGE,Mahalingam, D,Meersma, GJ,Ek, WBV,Hollema, H,Hooge, MNLD,van Dam, GM,Cool, RH,Quax, WJ,Samali, A,van der Zee, AGJ,de Jong, S (2009) 'Enhanced Antitumor Efficacy of a DR5-Specific TRAIL Variant over Recombinant Human TRAIL in a Bioluminescent Ovarian Cancer Xenograft Model'. Clinical Cancer Research, 15 :2048-2057 [DOI] [Details]
(2009) 'Targeting the endoplasmic reticulum-stress response as an anticancer strategy'
Healy SJ, Gorman AM, Mousavi-Shafaei P, Gupta S, Samali A (2009) 'Targeting the endoplasmic reticulum-stress response as an anticancer strategy'. European Journal Of Pharmacology, 625 (1-3):234-246 [DOI] [Details]
(2009) 'Targeting the endoplasmic reticulum-stress response as an anticancer strategy'
Healy, SJM,Gorman, AM,Mousavi-Shafaei, P,Gupta, S,Samali, A (2009) 'Targeting the endoplasmic reticulum-stress response as an anticancer strategy'. European Journal Of Pharmacology, 625 :234-246 [DOI] [Details]
(2009) 'TRAIL receptor signalling and modulation: Are we on the right TRAIL?'
Mahalingam, D.,Szegezdi, E.,Keane, M.,de Jong, S.,Samali, A. (2009) 'TRAIL receptor signalling and modulation: Are we on the right TRAIL?'. Cancer Treatment Reviews, 35 (33):280-288 [Details]
(2009) 'Bcl-2 family on guard at the ER'
Szegezdi E, Macdonald DC, Ní Chonghaile T, Gupta S, Samali A. (2009) 'Bcl-2 family on guard at the ER'. American Journal Of Physiology: Cell Physiology, [ARAN Link] [Details]
(2009) 'Bcl-2 family on guard at the ER'
Szegezdi E, Macdonald DC, Ní Chonghaile T, Gupta S, Samali A (2009) 'Bcl-2 family on guard at the ER'. American Journal Of Physiology, 296 (5):1-53 [DOI] [Details]
(2008) 'Metabolic flexibility permits mesenchymal stem cell survival in an ischemic environment'
Mylotte, LA;Duffy, AM;Murphy, M;O'Brien, T;Samali, A;Barry, F;Szegezdi, E (2008) 'Metabolic flexibility permits mesenchymal stem cell survival in an ischemic environment'. Stem Cells (Dayton, Ohio), 26 :1325-1336 [DOI] [Details]
(2008) 'Cytokine-induced beta-cell apoptosis is NO-dependent, mitochondria-mediated and inhibited by BCL-X-L'
Holohan, C;Szegezdi, E;Ritter, T;O'Brien, T;Samali, A (2008) 'Cytokine-induced beta-cell apoptosis is NO-dependent, mitochondria-mediated and inhibited by BCL-X-L'. Journal Of Cellular And Molecular Medicine, 12 :591-606 [DOI] [Details]
(2008) 'Increased expression of endoplasmic reticulum stress-related signaling pathway molecules in multiple sclerosis lesions'
Mhaille, AN;McQuaid, S;Windebank, A;Cunnea, P;McMahon, J;Samali, A;FitzGerald, U (2008) 'Increased expression of endoplasmic reticulum stress-related signaling pathway molecules in multiple sclerosis lesions'. Journal Of Neuropathology And Experimental Neurology, 67 :200-211 [Details]
(2008) 'Nerve growth factor blocks thapsigargin-induced apoptosis at the level of the mitochondrion via regulation of Bim'
Szegezdi E, Herbert KR, Kavanagh ET, Samali A, Gorman AM (2008) 'Nerve growth factor blocks thapsigargin-induced apoptosis at the level of the mitochondrion via regulation of Bim'. Journal Of Cellular And Molecular Medicine, 12 (6A):2482-2496 [DOI] [Details]
(2008) 'Increased expression of endoplasmic reticulum stress-related signaling pathway molecules in multiple sclerosis lesions'
Mhaille, A. N.,McQuaid, S.,Windebank, A.,Cunnea, P.,McMahon, J.,Samali, A.,FitzGerald, U. (2008) 'Increased expression of endoplasmic reticulum stress-related signaling pathway molecules in multiple sclerosis lesions'. J Neuropathol Exp Neurol, 67 (33):200-11 [Details]
(2008) 'Increased expression of endoplasmic reticulum stress-related signaling pathway molecules in multiple sclerosis lesions'
Mhaille, AN,McQuaid, S,Windebank, A,Cunnea, P,McMahon, J,Samali, A,FitzGerald, U (2008) 'Increased expression of endoplasmic reticulum stress-related signaling pathway molecules in multiple sclerosis lesions'. Journal Of Neuropathology And Experimental Neurology, 67 :200-211 [Details]
(2008) 'Cytokine-induced beta-cell apoptosis is NO-dependent, mitochondria-mediated and inhibited by BCL-X-L'
Holohan, C,Szegezdi, E,Ritter, T,O'Brien, T,Samali, A (2008) 'Cytokine-induced beta-cell apoptosis is NO-dependent, mitochondria-mediated and inhibited by BCL-X-L'. Journal Of Cellular And Molecular Medicine, 12 :591-606 [DOI] [Details]
(2008) 'Metabolic flexibility permits mesenchymal stem cell survival in an ischemic environment'
Mylotte, LA,Duffy, AM,Murphy, M,O'Brien, T,Samali, A,Barry, F,Szegezdi, E (2008) 'Metabolic flexibility permits mesenchymal stem cell survival in an ischemic environment'. Stem Cells and Development, 26 :1325-1336 [DOI] [Details]
(2008) 'DR4-selective tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) variants obtained by structure-based design'
Tur, V,van der Sloot, AM,Reis, CR,Szegezdi, E,Cool, RH,Samali, A,Serrano, L,Quax, WJ (2008) 'DR4-selective tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) variants obtained by structure-based design'. Journal Of Biological Chemistry, 283 :20560-20568 [DOI] [Details]
(2008) 'Y Nerve growth factor blocks thapsigargin-induced apoptosis at the level of the mitochondrion viaregulation of Bim'
Szegezdi, E,Reed Herbert, K,Kavanagh, ET,Samali, A,Gorman, AM (2008) 'Y Nerve growth factor blocks thapsigargin-induced apoptosis at the level of the mitochondrion viaregulation of Bim'. Journal Of Cellular And Molecular Medicine, 12 :2482-2496 [DOI] [Details]
(2008) 'Structure based design of a DR4 selective TRAIL variant'
Tur V, van der Sloot AM, Reis CR, Szegezdi E, Cool RH, Serrano L Samali A and Quax W (2008) 'Structure based design of a DR4 selective TRAIL variant'. Journal Of Biological Chemistry, 283 :20560-20568 [Details]
(2007) 'OxLDL-induced gene expression patterns in CASMC are mimicked in apoE(-/-) mice aortas'
Reeve, JLV,Stenson-Cox, C,O'Doherty, A,Porn-Ares, I,Ares, M,O'Brien, T,Samali, A (2007) 'OxLDL-induced gene expression patterns in CASMC are mimicked in apoE(-/-) mice aortas'. Biochemical And Biophysical Research Communications, 356 :681-686 [DOI] [Details]
(2007) 'Selective oxidative stress in cell nuclei by nuclear-targeted D-amino acid oxidase'
Halvey, PJ,Hansen, JM,Johnson, JM,Go, YM,Samali, A,Jones, DP (2007) 'Selective oxidative stress in cell nuclei by nuclear-targeted D-amino acid oxidase'. Antioxidants & Redox Signaling, 9 :807-816 [DOI] [Details]
(2007) 'Identification of an inhibitor of caspase activation from heart extracts; ATP blocks apoptosome formation'
Samali, A,O'Mahoney, M,Reeve, J,Logue, S,Szegezdi, E,McMahon, J,Fearnhead, HO (2007) 'Identification of an inhibitor of caspase activation from heart extracts; ATP blocks apoptosome formation'. Apoptosis, 12 :465-474 [DOI] [Details]
(2007) 'Distinct mechanisms of cardiomyocyte apoptosis induced by doxorubicin and hypoxia converge on mitochondria and are inhibited by Bcl-X-L'
Reeve, JLV,Szegezdi, E,Logue, SE,Chonghaile, TN,O'Brien, T,Ritter, T,Samali, A (2007) 'Distinct mechanisms of cardiomyocyte apoptosis induced by doxorubicin and hypoxia converge on mitochondria and are inhibited by Bcl-X-L'. Journal Of Cellular And Molecular Medicine, 11 :509-520 [DOI] [Details]
(2007) 'A tribute to professor Richard A. Lockshin on his 70th birthday'
Samali A (2007) 'A tribute to professor Richard A. Lockshin on his 70th birthday'. Journal Of Cellular And Molecular Medicine, 11 (6):1210-1211 [DOI] [Details]
(2007) 'Apoptosis: a mapped path to cell death'
Samali A (2007) 'Apoptosis: a mapped path to cell death'. Journal Of Cellular And Molecular Medicine, 11 (6):1212-1213 [DOI] [Details]
(2007) 'Distinct mechanisms of cardiomyocyte apoptosis induced by doxorubicin and hypoxia converge on mitochondria and are inhibited by Bcl-xL'
Reeve JL;Szegezdi E;Logue SE;Ní Chonghaile T;O'Brien T;Ritter T;Samali A; (2007) 'Distinct mechanisms of cardiomyocyte apoptosis induced by doxorubicin and hypoxia converge on mitochondria and are inhibited by Bcl-xL'. Journal Of Cellular And Molecular Medicine, 11 (3) [DOI] [Details]
(2006) 'Mediators of endoplasmic reticulum stress-induced apoptosis'
Szegezdi E;Logue SE;Gorman AM;Samali A; (2006) 'Mediators of endoplasmic reticulum stress-induced apoptosis'. Embo Reports, 7 (9) [DOI] [Details]
(2006) 'ER stress contributes to ischemia-induced cardiomyocyte apoptosis'
Szegezdi, E,Duffy, A,O'Mahoney, ME,Logue, SE,Mylotte, LA,O'Brien, T,Samali, A (2006) 'ER stress contributes to ischemia-induced cardiomyocyte apoptosis'. Biochemical And Biophysical Research Communications, 349 :1406-1411 [DOI] [Details]
(2006) 'Dexamethasone inhibits apoptosis in C6 glioma cells through increased expression of Bcl-X-L'
Ni Chonghaile, T,Concannon, CG,Szegezdi, E,Gorman, AM,Samali, A (2006) 'Dexamethasone inhibits apoptosis in C6 glioma cells through increased expression of Bcl-X-L'. Apoptosis, 11 :1247-1255 [DOI] [Details]
(2006) 'Mediators of ER stress-induced apoptosis'
Szegezdi E, Logue SE, Gorman AM and Samali A (2006) 'Mediators of ER stress-induced apoptosis'. EMBO Reports, 7 :880-885 [Details]
(2006) 'beta cell cytoprotective strategies: Establishing the relative roles for iNOS and ROS'
McCabe, C,Samali, A,O'Brien, T (2006) 'beta cell cytoprotective strategies: Establishing the relative roles for iNOS and ROS'. Biochemical And Biophysical Research Communications, 342 :1240-1248 [DOI] [Details]
(2006) 'ER stress contributes to ischemia-induced cardiomyocyte apoptosis'
Szegezdi E;Duffy A;O'Mahoney ME;Logue SE;Mylotte LA;O'brien T;Samali A; (2006) 'ER stress contributes to ischemia-induced cardiomyocyte apoptosis'. Biochemical And Biophysical Research Communications, 349 (4) [DOI] [Details]
(2006) 'TRAIL sensitisation by arsenic trioxide is caspase-8 dependent and involves modulation of death receptor components and Akt'
Szegezdi, E,Cahill, S,Meyer, M,O'Dwyer, M,Samali, A (2006) 'TRAIL sensitisation by arsenic trioxide is caspase-8 dependent and involves modulation of death receptor components and Akt'. British Journal Of Cancer, 94 :398-406 [DOI] [Details]
(2006) 'Distinct effects of high-glucose conditions on endothelial cells of macrovascular and microvascular origins'
Duffy, A,Liew, A,O'Sullivan, J,Avalos, G,Samali, A,O'Brien, T (2006) 'Distinct effects of high-glucose conditions on endothelial cells of macrovascular and microvascular origins'. Endothelium-Journal Of Endothelial Cell Research, 13 :9-16 [DOI] [Details]
(2006) 'Designed tumor necrosis factor-related apoptosis-inducing ligand variants initiating apoptosis exclusively via the DR5 receptor'
Van der Sloot, AM,Tur, V,Szegezdi, E,Mullally, MM,Cool, RH,Samali, A,Serrano, L,Quax, WJ (2006) 'Designed tumor necrosis factor-related apoptosis-inducing ligand variants initiating apoptosis exclusively via the DR5 receptor'. Proceedings Of The National Academy Of Sciences Of The United States Of America, 103 :8634-8639 [DOI] [Details]
(2006) 'Mediators of endoplasmic reticulum stress-induced apoptosis'
Szegezdi, E.,Logue, S. E.,Gorman, A. M.,Samali, A. (2006) 'Mediators of endoplasmic reticulum stress-induced apoptosis'. Embo Reports, 7 (99):880-885 [Details]
(2006) 'Cytoprotection of beta cells: rational gene transfer strategies'
McCabe C, Samali A, O'Brien T (2006) 'Cytoprotection of beta cells: rational gene transfer strategies'. Diabetes, 22 (3):241-252 [DOI] [Details]
(2006) 'Functionality of NGF-protected PC12 cells following exposure to 6-hydroxydopamine'
Kavanagh, ET,Loughlin, JP,Herbert, KR,Dockery, P,Samall, A,Doyle, KM,Gorman, AM (2006) 'Functionality of NGF-protected PC12 cells following exposure to 6-hydroxydopamine'. Biochemical And Biophysical Research Communications, 351 :890-895 [DOI] [Details]
(2005) 'Compartmental oxidation of thiol-disulphide redox couples during epidermal growth factor signalling'
Halvey PJ, Watson WH, Hansen JM, Go YM, Samali A, Jones DP (2005) 'Compartmental oxidation of thiol-disulphide redox couples during epidermal growth factor signalling'. Biochemical Journal, 386 (Pt 2):215-219 [DOI] [Details]
(2005) 'Hsp27 inhibits 6-Hydroxydopamine induces both apoptosis and heat shock response in PC12 cells: role of hsp27 in protection against apoptosis'
Gorman A.M., Szegezdi E., Quigney D., Samali A. (2005) 'Hsp27 inhibits 6-Hydroxydopamine induces both apoptosis and heat shock response in PC12 cells: role of hsp27 in protection against apoptosis'. Biochemical And Biophysical Research Communications, 327 :801-810 [Details]
(2005) 'Compartmental oxidation of thiol/disulfide redox couples during EGF signaling'
Halvey P.J., Watson W.H., Hansen J.M., Go Y-M., Samali A., Jones D.P. (2005) 'Compartmental oxidation of thiol/disulfide redox couples during EGF signaling'. Biochem. J, 386 :215-219 [DOI] [Details]
(2005) 'Hsp27 inhibits 6-hydroxydopamine-induced cytochrome c release and apoptosis in PC12 cells'
Gorman, AM,Szegezdi, E,Quigney, DJ,Samali, A (2005) 'Hsp27 inhibits 6-hydroxydopamine-induced cytochrome c release and apoptosis in PC12 cells'. Biochemical And Biophysical Research Communications, 327 :801-810 [DOI] [Details]
(2005) 'CD95-mediated alteration in Hsp70 levels is dependent on protein stabilisation'
Concannon G., Holmberg C., FitzGerald U., Szegezdi E., Sistonen L. and Samali A. (2005) 'CD95-mediated alteration in Hsp70 levels is dependent on protein stabilisation'. Cell Stress And Chaperones, 10 (l):59-65 [DOI] [Details]
(2005) 'CD95-mediated alteration in Hsp70 levels is dependent on protein stabilization'
Concannon, CG;FitzGerald, U;Holmberg, CI;Szegezdi, E;Sistonen, L;Samali, A (2005) 'CD95-mediated alteration in Hsp70 levels is dependent on protein stabilization'. Cell Stress & Chaperones, 10 :59-65 [Details]
(2005) 'Don’t loose Heart: Therapeutic value of anti-apoptotic strategies in the treatment of cardiovascular disease'
Reeve J., Duffy A., O'Brien T., Samali A. (2005) 'Don’t loose Heart: Therapeutic value of anti-apoptotic strategies in the treatment of cardiovascular disease'. J. Cell. Mol. Med, :609-622 [Details]
(2005) 'Don't lose heart--therapeutic value of apoptosis prevention in the treatment of cardiovascular disease'
Reeve JL, Duffy AM, O'Brien T, Samali A (2005) 'Don't lose heart--therapeutic value of apoptosis prevention in the treatment of cardiovascular disease'. Journal Of Cellular And Molecular Medicine, 9 (3):609-622 [Details]
(2005) 'Ischemia/reperfusion injury at the intersection with cell death'
Logue SE, Gustafsson AB, Samali A, Gottlieb RA (2005) 'Ischemia/reperfusion injury at the intersection with cell death'. Molecular Cell, 38 (1):21-33 [DOI] [Details]
(2005) 'Compartmental oxidation of thiol-disulphide redox couples during epidermal growth factor signalling'
Halvey, PJ,Watson, WH,Hansen, JM,Go, YM,Samali, A,Jones, DP (2005) 'Compartmental oxidation of thiol-disulphide redox couples during epidermal growth factor signalling'. Biochemical Journal, 386 :215-219 [DOI] [Details]
(2005) 'Ischemia/reperfusion injury at the intersection with cell death'
Logue SE;Gustafsson AB;Samali A;Gottlieb RA; (2005) 'Ischemia/reperfusion injury at the intersection with cell death'. Journal Of Molecular And Cellular Cardiology, 38 (1) [DOI] [Details]
(2005) '6-Hydroxydopamine induces both apoptosis and heat shock response in PC12 cells: role of hsp27 in protection against apoptosis'
Gorman A.M., Szegezdi E., Quigney D., Samali A. (2005) '6-Hydroxydopamine induces both apoptosis and heat shock response in PC12 cells: role of hsp27 in protection against apoptosis'. Biochem. Biophys. Res. Commun, 327 :801-810 [Details]
(2004) 'The switch from survival responses to apoptosis after chromosomal breaks'
Bree R, Neary C, Samali A and Lowndes NF (2004) 'The switch from survival responses to apoptosis after chromosomal breaks'. DNA Repair, 3 :989-995 [Details]
(2003) 'Hypoxia and ischemia induce nuclear condensation and caspase activation in cardiomyocytes'
O'Mahoney M, Logue SE, Szegezdi E, FitzGerald U, Samali A (2003) 'Hypoxia and ischemia induce nuclear condensation and caspase activation in cardiomyocytes'. Apoptosis: From Signaling Pathways To Therapeutic Tools, 1010 :728-732 [Details]
(2003) 'Arsenic trioxide sensitizes leukemic cells to TRAIL-induced apoptosis'
Cahill S, Szegezdi E, Samali A, O'Dwyer M (2003) 'Arsenic trioxide sensitizes leukemic cells to TRAIL-induced apoptosis'. Blood, 102 :861A-861A [Details]
(2003) 'In the cut and thrust of apoptosis, serine proteases come of age'
Stenson-Cox, C.M., FitzGerald, U., Samali, A. (2003) 'In the cut and thrust of apoptosis, serine proteases come of age'. Biochem Biopharm, 66 :1469-1474 [Details]
(2003) 'On the role of Hsp27 in regulating apoptosis'
Concannon CG, Gorman AM, Samali A (2003) 'On the role of Hsp27 in regulating apoptosis'. Apoptosis, 8 :61-70 [Details]
(2003) 'Heat shock protects PC12 cells against MPP+ toxicity'
Quigney, DJ,Gorman, AM,Samali, A (2003) 'Heat shock protects PC12 cells against MPP+ toxicity'. Brain Research, 993 :133-139 [DOI] [Details]
(2003) 'Heat shock protects PC12 cells against MPP+ toxicity'
Quigney, DJ;Gorman, AM;Samali, A (2003) 'Heat shock protects PC12 cells against MPP+ toxicity'. Brain Research, 993 :133-139 [DOI] [Details]
(2003) 'Heat shock inhibits MPP+-induced cell death in PC-12 cells'
Quigney D., Gorman A.M., Samali A. (2003) 'Heat shock inhibits MPP+-induced cell death in PC-12 cells'. Brain Res, 993 :133-139 [Details]
(2003) 'Caspase-12 and ER-stress-mediated apoptosis - The story so far'
Szegezdi, E,Fitzgerald, U,Samali, A,Diederich, M (2003) 'Caspase-12 and ER-stress-mediated apoptosis - The story so far'. Annals Of The New York Academy Of Sciences, 1010 :186-194 [DOI] [Details]
(2003) 'Caspase-12 and ER-stress-mediated apoptosis: the story so far'
Szegezdi E, Fitzgerald U, Samali A (2003) 'Caspase-12 and ER-stress-mediated apoptosis: the story so far'. Annals of the New York Academy of Sciences, 1010 :186-194 [Details]
(2003) 'Hypoxia and ischemia induce nuclear condensation and caspase activation in cardiomyocytes'
O'Mahoney ME, Logue S, Szegezdi E, Stenson-Cox C, Fitzgerald U, Samali A (2003) 'Hypoxia and ischemia induce nuclear condensation and caspase activation in cardiomyocytes'. Annals of the New York Academy of Sciences, 1010 :728-732 [Details]
(2002) 'Losing heart: the role of apoptosis in heart disease--a novel therapeutic target?'
Gill C, Mestril R, Samali A (2002) 'Losing heart: the role of apoptosis in heart disease--a novel therapeutic target?'. Faseb Journal, 16 (2):135-146 [DOI] [Details]
(2001) 'Determination of apoptosis and necrosis'
Zhivotovsky B, Samali A, Orrenius S (2001) 'Determination of apoptosis and necrosis'. Current protocols in toxicology / editorial board, Mahin D. Maines (editor-in-chief) ... [et al.], Chapter 2 [DOI] [Details]
(2001) 'Hsp27 inhibits cytochrome c-mediated caspase activation by sequestering both pro-caspase-3 and cytochrome c'
Concannon, CG,Orrenius, S,Samali, A (2001) 'Hsp27 inhibits cytochrome c-mediated caspase activation by sequestering both pro-caspase-3 and cytochrome c'. Gene Expression, 9 :195-201 [Details]
(2001) 'Hsp27 inhibits cytochrome c-mediated caspase activation by sequestering both pro-caspase-3 and cytochrome c'
Concannon, CG;Orrenius, S;Samali, A (2001) 'Hsp27 inhibits cytochrome c-mediated caspase activation by sequestering both pro-caspase-3 and cytochrome c'. Gene Expression, 9 :195-201 [Details]
(2001) 'Interleukin-1, interleukin-8, tumor necrosis factor alpha and inteferon gamma stimulate DNA synthesis but have no effect on apoptosis in small-intestinal cell lines'
Zachrisson C., Neopikhanov V., Samali A., Uribe A. (2001) 'Interleukin-1, interleukin-8, tumor necrosis factor alpha and inteferon gamma stimulate DNA synthesis but have no effect on apoptosis in small-intestinal cell lines'. Eur. J. Gastro. Hepatol, 13 :551-559 [Details]
(2001) 'Current concepts in cell toxicity'
Samali A, Zhivotovsky B, Orrenius S (2001) 'Current concepts in cell toxicity'. Current protocols in toxicology / editorial board, Mahin D. Maines (editor-in-chief) ... [et al.], Chapter 2 [DOI] [Details]
(2001) 'Hsp27 protects mitochondria of thermotolerant cells against apoptotic stimuli'
Samali, A;Robertson, JD;Peterson, E;Manero, F;van Zeijl, L;Paul, C;Cotgreave, IA;Arrigo, AP;Orrenius, S (2001) 'Hsp27 protects mitochondria of thermotolerant cells against apoptotic stimuli'. Cell Stress & Chaperones, 6 :49-58 [Details]
(2001) 'Hsp27 protects mitochondria of thermotolerant cells against apoptotic stimuli'
Samali, A,Robertson, JD,Peterson, E,Manero, F,van Zeijl, L,Paul, C,Cotgreave, IA,Arrigo, AP,Orrenius, S (2001) 'Hsp27 protects mitochondria of thermotolerant cells against apoptotic stimuli'. Cell Stress & Chaperones, 6 :49-58 [Details]
(2000) 'Triggering and modulation of apoptosis by oxidative stress'
Chandra J, Samali A, Orrenius S (2000) 'Triggering and modulation of apoptosis by oxidative stress'. Free radical biology & medicine, 29 (3-4):323-333 [Details]
(2000) 'Soluble proteins of Helicobacter pylori stimulate DNA synthesis in epithelial cell lines without affecting apoptosis'
Neopikhanov V., Samali A., Wreiber K., Engstrand L., Uribe A. (2000) 'Soluble proteins of Helicobacter pylori stimulate DNA synthesis in epithelial cell lines without affecting apoptosis'. Digestion, 61 :22-29 [Details]
(2000) '40- to 100-kD protein(s) of Helicobacter pylori stimulate DNA synthesis in epithelial cell lines without affecting apoptosis'
Neopikhanov V, Samali A, Wreiber K, Engstrand L, Uribe A (2000) '40- to 100-kD protein(s) of Helicobacter pylori stimulate DNA synthesis in epithelial cell lines without affecting apoptosis'. Digestion, 61 (1):22-29 [DOI] [Details]
(1999) 'Antioxidant-mediated inhibition of the heat shock response leads to apoptosis'
Gorman, AM;Heavey, B;Creagh, E;Cotter, TG;Samali, A (1999) 'Antioxidant-mediated inhibition of the heat shock response leads to apoptosis'. Febs Letters, 445 :98-102 [Details]
(1999) 'Thermotolerance and cell death are distinct cellular responses to stress: dependence on heat shock proteins'
Samali, A;Holmberg, CI;Sistonen, L;Orrenius, S (1999) 'Thermotolerance and cell death are distinct cellular responses to stress: dependence on heat shock proteins'. Febs Letters, 461 :306-310 [Details]
(1999) 'A comparative study of apoptosis and necrosis in HepG2 cells: oxidant-induced caspase inactivation leads to necrosis'
Samali A, Nordgren H, Zhivotovsky B, Peterson E, Orrenius S (1999) 'A comparative study of apoptosis and necrosis in HepG2 cells: oxidant-induced caspase inactivation leads to necrosis'. Biochem, 255 (1):6-11 [DOI] [Details]
(1999) 'Presence of a pre-apoptotic complex of pro-caspase-3, Hsp60 and Hsp10 in the mitochondrial fraction of jurkat cells'
Samali A, Cai J, Zhivotovsky B, Jones DP, Orrenius S (1999) 'Presence of a pre-apoptotic complex of pro-caspase-3, Hsp60 and Hsp10 in the mitochondrial fraction of jurkat cells'. Embo Journal, 18 (8):2040-2048 [DOI] [Details]
(1999) 'Apoptosis: cell death defined by caspase activation'
Samali A, Zhivotovsky B, Jones D, Nagata S, Orrenius S (1999) 'Apoptosis: cell death defined by caspase activation'. Cell Death And Differentiation, 6 (6):495-496 [DOI] [Details]
(1999) 'Caspases: their intracellular localization and translocation during apoptosis'
Zhivotovsky B, Samali A, Gahm A, Orrenius S (1999) 'Caspases: their intracellular localization and translocation during apoptosis'. Cell Death And Differentiation, 6 (7):644-651 [DOI] [Details]
(1999) 'Phosphatidylserine exposure during apoptosis is a cell-type-specific event and does not correlate with plasma membrane phospholipid scramblase expression'
Fadeel B, Gleiss B, Högstrand K, Chandra J, Wiedmer T, Sims PJ, Henter JI, Orrenius S, Samali A (1999) 'Phosphatidylserine exposure during apoptosis is a cell-type-specific event and does not correlate with plasma membrane phospholipid scramblase expression'. Biochem, 266 (2):504-511 [DOI] [Details]
(1999) 'Antioxidant-mediated inhibition of the heat shock response leads to apoptosis'
Gorman, AM,Heavey, B,Creagh, E,Cotter, TG,Samali, A (1999) 'Antioxidant-mediated inhibition of the heat shock response leads to apoptosis'. Febs Letters, 445 :98-102 [Details]
(1999) 'Thermotolerance and cell death are distinct cellular responses to stress: dependence on heat shock proteins'
Samali, A,Holmberg, CI,Sistonen, L,Orrenius, S (1999) 'Thermotolerance and cell death are distinct cellular responses to stress: dependence on heat shock proteins'. Febs Letters, 461 :306-310 [Details]
(1998) 'Heat shock proteins: regulators of stress response and apoptosis'
Samali A, Orrenius S (1998) 'Heat shock proteins: regulators of stress response and apoptosis'. Cell Stress & Chaperones, 3 (4):228-236 [Details]
(1998) 'Cleavage of the calpain inhibitor, calpastatin, during apoptosis'
Pörn-Ares MI, Samali A, Orrenius S (1998) 'Cleavage of the calpain inhibitor, calpastatin, during apoptosis'. Cell Death And Differentiation, 5 (12):1028-1033 [DOI] [Details]
(1998) 'Detection of pro-caspase-3 in cytosol and mitochondria of various tissues'
Samali A, Zhivotovsky B, Jones DP, Orrenius S (1998) 'Detection of pro-caspase-3 in cytosol and mitochondria of various tissues'. Febs Letters, 431 (2):167-169 [Details]
(1997) 'The ability to cleave 28S ribosomal RNA during apoptosis is a cell-type dependent trait unrelated to DNA fragmentation'
Samali A, Gilje B, Døskeland SO, Cotter TG, Houge G (1997) 'The ability to cleave 28S ribosomal RNA during apoptosis is a cell-type dependent trait unrelated to DNA fragmentation'. Cell Death And Differentiation, 4 (4):289-293 [DOI] [Details]
(1997) 'Use of flow cytometry techniques in studying mechanisms of apoptosis in leukemic cells'
Gorman, AM,Samali, A,McGowan, AJ,Cotter, TG (1997) 'Use of flow cytometry techniques in studying mechanisms of apoptosis in leukemic cells'. Cytometry, 29 :97-105 [Details]
(1997) 'Role of Bcr-abl in resistance to apoptosis'
Samali A, Gorman A, Cotter TG (1997) 'Role of Bcr-abl in resistance to apoptosis'. Adv. Pharmacol, 41 :533-552 [Details]
(1996) 'Apoptosis -- the story so far'
Samali A, Gorman AM, Cotter TG (1996) 'Apoptosis -- the story so far'. Experientia, 52 (10-11):933-941 [Details]
(1996) 'Heat shock proteins increase resistance to apoptosis'
Samali, A,Cotter, TG (1996) 'Heat shock proteins increase resistance to apoptosis'. Experimental Cell Research, 223 :163-170 [Details]
(1996) 'Anti-oxidants and apoptosis'
McGowan AJ, Fernandes RS, Samali A, Cotter TG (1996) 'Anti-oxidants and apoptosis'. Biochemical Society Transactions, 24 (1):229-233 [Details]

Book Chapters

  Year Publication
(2018) 'eIF2 alpha'
Pakos-Zebrucka K, Gorman A, Chintha C, Chevet E, Samali A, Mnich K (2018) 'eIF2 alpha' In: Encyclopedia of Signaling Molecules. https://www.springer.com/gp: Springer International Publishing. [DOI] [Details]
(2011) 'ASSAYS FOR DETECTING THE UNFOLDED PROTEIN RESPONSE'
Cawley, K,Deegan, S,Samali, A,Gupta, S (2011) 'ASSAYS FOR DETECTING THE UNFOLDED PROTEIN RESPONSE' In: Methods in enzymology. :31-51 UK: Elsevier Inc. [DOI] [Details]
(2015) 'Induction of autophagy: Role of endoplasmic reticulum stress and unfolded protein response'
Yeganeh B, Jäger R, Gorman AM, Samali A, Ghavami S (2015) 'Induction of autophagy: Role of endoplasmic reticulum stress and unfolded protein response' In: AUTOPHAGY. CANCER, OTHER PATHOLOGIES, INFLAMMATION, IMMUNITY AND INFECTION. :97-101 Netherlands: Elsevier Inc. [Details]
(2011) 'The Unfolded Protein Response and Cellular Stress, Part 2'
Karen Cawley, Shane Deegan, Afshin Samali, Sanjeev Gupta (2011) 'The Unfolded Protein Response and Cellular Stress, Part 2' In: Methods in enzymology. UK: Elsevier Inc. [DOI] [Details]
(2012) 'ER stress signaling pathways in cell survival and death'
Verfaillie, T; Jäger, R; Samali, A; Agostinis, P (2012) 'ER stress signaling pathways in cell survival and death' In: ER stress in health and disease. New York: Springer. [Details]
(2012) 'Biology of the Endoplasmic Reticulum'
Sandra JM Healy, Tom Verfaillie, Richard Jager, Patrizia Agostinis and Afshin Samali (2012) 'Biology of the Endoplasmic Reticulum' In: ER Stress in Health and Disease. Dordrecht, Netherlands: Springer Science+Business Media. [Details]
(2011) 'Cytokine-Induced β-Cell Stress and Death in Type 1 Diabetes Mellitus'
Vincenz L, Szegezdi E, Jaeger R, Holohan C, O'Brien T, Samali A. (2011) 'Cytokine-Induced β-Cell Stress and Death in Type 1 Diabetes Mellitus' In: Type 1 Diabetes - Complications, Pathogenesis, and Alternative Treatments. Rijeka, Croatia: InTech publishers. [DOI] [Details]
(2006) 'The role of heat shock proteins in neuronal differentiation and development'
Reed Herbert K, Samali A, Gorman AM. (2006) 'The role of heat shock proteins in neuronal differentiation and development' In: Heat Shock Proteins in Neural Cells. :25-37 TX, USA: Landes Bioscience. [Details]
(2006) 'Heat shock proteins and the regulation of apoptosis'
Fitzgerald, U, Gorman AM, Samali A. (2006) 'Heat shock proteins and the regulation of apoptosis' In: Heat Shock Proteins in Neural Cells. :53-66 TX, USA: Landes Bioscience. [Details]
(2005) 'Heat shock proteins in regulation of neural apoptosis'
FitzGerald U., Gorman A.M., Samali A. (2005) 'Heat shock proteins in regulation of neural apoptosis' In: Heat Shock Proteins in Neural Cells. :53-62 TX, USA: Landes Bioscience. [Details]
(2005) 'The role of heat shock proteins in neuronal differentiation and development'
Herbert-Reed K., Samali A., Gorman A.M. (2005) 'The role of heat shock proteins in neuronal differentiation and development' In: Heat Shock Proteins in Neural Cells. :25-33 Landes Bioscience, TX, USA. [Details]
(2005) 'Molecular basis of inhibition of apoptosis by Heat shock proteins'
Gill C., Meyer M., Samali A. (2005) 'Molecular basis of inhibition of apoptosis by Heat shock proteins' In: Stress response: a molecular Biology approach. Research Signpost, India. [Details]
(1999) 'Measurement of cells in culture'
Samali A., Cotter T.G. (1999) 'Measurement of cells in culture' In: Animal Cell Biotechnology: Methods and protocols (Methods in Biotechnology series). :155-164 Germany: Springer. [DOI] [Details]
(1999) 'Current Concepts in Cell Toxicity'
Samali A., Zhivotovsky B., Orrenius S. (1999) 'Current Concepts in Cell Toxicity' In: Current Protocols in Toxicology. :2.1.1-2.1.16 New York: John Wiley and Sons, Inc. [DOI] [Details]
(1999) 'Methods for the detection of apoptosis and necrosis'
Zhivotovsky B., Samali A., Orrenius S. (1999) 'Methods for the detection of apoptosis and necrosis' In: Current Protocols in Toxicology. :2.2.1-2.2.33 NJ, USA: John Wiley and Sons, Inc. [DOI] [Details]

Conference Publications

  Year Publication
(2019) CYTOKINE
Duvigneau, JC;Luis, A;Gorman, AM;Samali, A;Kaltenecker, D;Moriggl, R;Kozlov, AV (2019) Crosstalk between inflammatory mediators and endoplasmic reticulum stress in liver diseases CYTOKINE [DOI] [Details]
(2013) Perk-dependent repression of miR-106b-25 cluster is required for ER stress induced apoptosis
Read, DE,Agostinis, P,Hetz, C,Mott, JL,Samali, A,Gupta, S (2013) Perk-dependent repression of miR-106b-25 cluster is required for ER stress induced apoptosis , pp.117-120 [Details]
(2011) Advances in Tnf Family Research
Reis, C. R.,van der Sloot, A. M.,Szegezdi, E.,Natoni, A.,Tur, V.,Cool, R. H.,Samali, A.,Serrano, L.,Quax, W. J. (2011) Enhancement of Antitumor Properties of Rhtrail by Affinity Increase toward Its Death Receptors Advances in Tnf Family Research , pp.807-808 [Details]
(2011) Advances in Tnf Family Research
Quax, W. J.,Reis, C. R.,van der Sloot, A. M.,Tur, V.,Szegezdi, E.,Natoni, A.,Cool, R. H.,Samali, A.,Serrano, L. (2011) Designed Receptor Specific Rhtrail Variants Enhance Induction of Apoptosis in Cancer Cells Advances in Tnf Family Research , pp.726-727 [Details]
(2011) Improved Tumor Cell Killing by Trail Requires Selective and High Affinity Receptor Activation
Szegezdi, E.,van der Sloot, A. M.,Alessandro, N.,Mahalingam, D.,Cool, R. H.,Munoz, I. G.,Montoya, G.,Quax, W. J.,Serrano, S. D. L.,Samali, A. (2011) Improved Tumor Cell Killing by Trail Requires Selective and High Affinity Receptor Activation , pp.808-808 [Details]
(2011) Advances in Tnf Family Research
van der Sloot, A. M.,Szegezdi, E.,Reis, C. R.,Tur, V.,Quax, W. J.,Samali, A.,Serrano, L. (2011) Computational Design of Receptor Selective Trail Variants Advances in Tnf Family Research , pp.809-809 [Details]
(2010) Annual Conference of the Society-for-Glycobiology
Gupta, S; Gerlach, J; Miura, Y; Yamazaki, T; Nakahara, T; Asada, H; Samali, A; Joshi, L. (2010) High Throughput Glycanmap (R) Analysis of Glycosylation during ER Stress and Apoptosis in a Colon Cancer Model.Glycobiology Volume: 20 Issue: 11 Pages: 1471 Annual Conference of the Society-for-Glycobiology [Details]
(2010) RAMI Conference
van Dijk, M.,Samali, A.,Szegezdi, E. (2010) Mechanism of Trail Resistance in Non-Transformed Cells RAMI Conference [Details]
(2010) 8th World Congress on Trauma, Shock, Inflammation and Sepsis
Nuernberger, S,Gupta, S,Kavanagh, ET,Duvigneau, JC,Miller, I,Hori, O,Samali, A,Redl, H,Kozlov, AV (2010) Ultrastructural changes and underlying molecular mechanisms in rat livers induced by endotoxic shock. Nuernberger, S.; Gupta, S.; Kavanagh, E. T.; et al. Shock Volume: 33 Pages: 79 8th World Congress on Trauma, Shock, Inflammation and Sepsis , pp.79-79 [Details]
(2010) American Society of Hematology Meeting Abstract
Morrell, R. C.,Szegezdi, E.,Halpin-McCormick, A.,Cawley, K.,Samali, A.,O'Dwyer, M. (2010) The BH3 Mimetic, ABT-737, Overcomes Stromal-Mediated Pro-Survival Signals and Synergizes with PHA-767491, a Dual Cdc7/CDK9 Inhibitor, In Acute Myeloid Leukaemia American Society of Hematology Meeting Abstract , pp.768-768 [Details]
(2009) Is There a Role for Nuclear Factor kappa B in Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Resistance?
Plantivaux, A,Szegezdi, E,Samali, A,Egan, L (2009) NATURAL COMPOUNDS AND THEIR ROLE IN APOPTOTIC CELL SIGNALING PATHWAYS Is There a Role for Nuclear Factor kappa B in Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Resistance? , pp.38-49 [DOI] [Details]
(2009) PHA767491, a Dual Cdc7/CDK9 Inhibitor, with Potential to Target Both Proliferation and Survival in CLL
Natoni, A,Hayat, A,Montagnoli, A,Callagy, G,Samali, A,Santocanale, C,O'Dwyer, MC (2009) BLOOD PHA767491, a Dual Cdc7/CDK9 Inhibitor, with Potential to Target Both Proliferation and Survival in CLL , pp.934-934 [Details]
(2009) NATURAL COMPOUNDS AND THEIR ROLE IN APOPTOTIC CELL SIGNALING PATHWAYS
Plantivaux, A;Szegezdi, E;Samali, A;Egan, L (2009) Is There a Role for Nuclear Factor kappa B in Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Resistance? NATURAL COMPOUNDS AND THEIR ROLE IN APOPTOTIC CELL SIGNALING PATHWAYS , pp.38-49 [DOI] [Details]
(2008) APOPTOSIS: FROM SIGNALING PATHWAYS TO THERAPEUTIC TOOLS
Plantivaux A, Szegezdi E, Samali A, Egan LJ. (2008) TRAIL resistance in colon cancer cells: is NF-kB involved APOPTOSIS: FROM SIGNALING PATHWAYS TO THERAPEUTIC TOOLS [Details]
(2007) Proceedings Of The American Association For Cancer Research. Annual Meeting
Szegezdi E, Mahalingam D, Van der Sloot A, Quax W, Keane M, Samali A (2007) Decoy-insensitive TRAIL variants kill tumour cells more efficiently without damaging non-transformed cells Proceedings Of The American Association For Cancer Research. Annual Meeting [Details]
(2005) Irish Angiology Society Fifth Annual Meeting
Duffy A, Liew A, O' Sullivan J, Samali A, Avalos G, O' Brien T (2005) Distinct Effects of High Glucose Conditions on endothelial cells of macrovascular and microvascular origin Irish Angiology Society Fifth Annual Meeting Galway, Ireland, [Details]
(2003) American Society of Hematology. Meeting Abstract
Cahill, S.,Szegezdi, E.,Samali, A.,O'Dwyer, M. (2003) Arsenic trioxide sensitizes leukemic cells to TRAIL-induced apoptosis American Society of Hematology. Meeting Abstract [Details]
(2003) Biochemical Pharmacology
Stenson-Cox, C,FitzGerald, U,Samali, A (2003) In the cut and thrust of apoptosis, serine proteases come of age Biochemical Pharmacology , pp.1469-1474 [DOI] [Details]
(2003) BIOCHEMICAL PHARMACOLOGY
Stenson-Cox, C;FitzGerald, U;Samali, A (2003) In the cut and thrust of apoptosis, serine proteases come of age BIOCHEMICAL PHARMACOLOGY , pp.1469-1474 [DOI] [Details]
(2003) APOPTOSIS: FROM SIGNALING PATHWAYS TO THERAPEUTIC TOOLS
O'Mahoney, ME;Logue, S;Szegezdi, E;Stenson-Cox, C;Fitzgerald, U;Samali, A (2003) Hypoxia and ischemia induce nuclear condensation and caspase activation in cardiomyocytes APOPTOSIS: FROM SIGNALING PATHWAYS TO THERAPEUTIC TOOLS , pp.728-732 [DOI] [Details]
(2003) Apoptosis: From signaling pathways to therapeutic tools
O'Mahoney, ME,Logue, S,Szegezdi, E,Stenson-Cox, C,Fitzgerald, U,Samali, A (2003) Hypoxia and ischemia induce nuclear condensation and caspase activation in cardiomyocytes Apoptosis: From signaling pathways to therapeutic tools , pp.728-732 [DOI] [Details]
(1996) Anti-oxidants and apoptosis
McGowan, AJ,Fernandes, RS,Samali, A,Cotter, TG (1996) BIOCHEMICAL SOCIETY TRANSACTIONS Anti-oxidants and apoptosis , pp.229-233 [Details]

Edited Books

  Year Publication
(2012) ER stress in health and disease.
Patrizia Agostinis and Afshin Samali (Ed.). (2012) ER stress in health and disease ER stress in health and disease. Amsterdam: Springer. [Details]

Other Journals

  Year Publication
(2020) '1. Downregulation of miR-17-92 cluster by PERK fine-tunes unfolded protein response mediated apoptosis'
Danielle E. Read, Ananya Gupta, Karen Cawley, Laura Fontana, Patrizia Agostinis, Afshin Samali, Sanjeev Gupta (2020) '1. Downregulation of miR-17-92 cluster by PERK fine-tunes unfolded protein response mediated apoptosis' BioRxiv, . [DOI] [Details]
'Loss of Dicer1 in mouse embryonic fibroblasts impairs ER stress-induced apoptosis'
Ananya Gupta, Danielle Read, Deepu Oommen, Afshin Samali, SANJEEV GUPTA 'Loss of Dicer1 in mouse embryonic fibroblasts impairs ER stress-induced apoptosis' Biorxiv, . [DOI] [Details]

Conference Contributions

  Year Publication
(2018) Irish Association for Cancer Research Meeting,
Susan E Logue, Patricia Cleary, Eoghan McGrath, Katarzyna Mnich, Stephanie Green, John Patterson, Richard Jäger and Afshin Samali (2018) TARGETING THE IRE1 SIGNALLING AXIS IN BREAST CANCER. [Oral Presentation], Irish Association for Cancer Research Meeting, Dublin 2018 , 21-FEB-18 - 23-FEB-18. [Details]
(2018) ER stress in cancer and neurodegeneration,
Susan E Logue, Eoghan P McGrath, Patricia Cleary, Stephanie Greene, Katarzyna Mnich, Aitor Almanza, Eric Chevet, Róisín M Dwyer, Anup Oommen, Patrick Legembre, Florence Godey, Emma C Madden, Joanna Obacz, Qingping Zeng, John B Patterson, Richard Jäger, Adrienne M Gorman and Afshin Samali (2018) Targeting the IRE1 signalling axis in breast cancer. [Conference Organising Committee Chairperson], ER stress in cancer and neurodegeneration, Galway , 18-APR-18 - 18-JUN-18. [Details]
(2017) ER Stress, Autophagy & Immune System,
Susan E Logue, Patricia Cleary, Eoghan McGrath, Katarzyna Mnich, Stephanie Green, John Patterson, Richard Jäger and Afshin Samali (2017) Inhibition of IRE1α RNase activity modulates the secretome of Triple Negative Breast Cancer cells and enhances the effectiveness of chemotherapy. [Poster Presentation], ER Stress, Autophagy & Immune System, Bruges , 26-JAN-17 - 27-JAN-17. [Details]
(2017) Irish Association for Cancer Research Meeting 2017,
Susan E Logue, Patricia Cleary, Eoghan McGrath, Katarzyna Mnich, Stephanie Green, John Patterson, Richard Jäger and Afshin Samali (2017) Inhibition of IRE1α RNase activity modulates the secretome of Triple Negative Breast Cancer cells and enhances the effectiveness of chemotherapy. [Oral Presentation], Irish Association for Cancer Research Meeting 2017, Kilkenny , 22-FEB-17 - 24-FEB-17. [Details]
(2017) Endoplasmic Reticulum functions in physiology and pathology,
Susan E Logue, Patricia Cleary, Eoghan McGrath, Katarzyna Mnich, Stephanie Green, John Patterson, Richard Jäger, Eric Chevet and Afshin Samali (2017) IRE1-XBP1 as a therapeutic target in breast cancer. [Conference Organising Committee Chairperson], Endoplasmic Reticulum functions in physiology and pathology, Paris , 02-OCT-17 - 03-OCT-17. [Details]
(2016) ER Stress Symposium,
Susan E Logue, Patricia Cleary, Eoghan McGrath, Katarzyna Mnich, Stephanie Green, John Patterson, Richard Jäger and Afshin Samali (2016) Inhibition of IRE1α RNase activity modulates the secretome of Triple Negative Breast Cancer cells and enhances the effectiveness of chemotherapy. [Conference Organising Committee Chairperson], ER Stress Symposium, Galway , 26-MAY-16 - 27-MAY-16. [Details]
(2016) European Cell Death Organisation Meeting 2016,
Susan E Logue, Patricia Cleary, Eoghan McGrath, Katarzyna Mnich, Stephanie Green, John Patterson, Richard Jäger and Afshin Samali (2016) Inhibition of IRE1α RNase activity modulates the secretome of Triple Negative Breast Cancer cells and enhances the effectiveness of chemotherapy. [Invited Oral Presentation], European Cell Death Organisation Meeting 2016, Barcelona , 01-SEP-16 - 04-SEP-16. [Details]
(2013) BELPSO Meeting,
Logue SE, Deegan S, Saveljeva S, Pakos-Zebrucka K, Gupta S, Vandenabeele P, Bertrand MJ, Samali A. (2013) Deficiency in the mitochondrial apoptotic pathway reveals the toxic potential of autophagy under ER stress conditions. [Oral Presentation], BELPSO Meeting, Ghent , 04-APR-13 - 06-APR-13. [Details]
(2010) Apoptosis Symposium,
Gorman A, Szegezdi E, Samali A. (2010) A one day international meeting of researchers in Galway, 2010. [Conference Organising Committee Member], Apoptosis Symposium, Galway , 20-AUG-10 - 20-AUG-10. [Details]
(2010) Annual Conference of the Society for Glycobiology,
Sanjeev Gupt1, Jared Gerlach, Yoshiaki Miura, Toshiaki Yamazaki3, Taku Nakahara, Hidehisa Asada, Afshin Samali and Lokesh Joshi (2010) High throughput GlycanMap® analysis of glycosylation during ER stress and apoptosis in a colon cancer model. [Poster Presentation], Annual Conference of the Society for Glycobiology, Florida, USA , 07-NOV-10 - 10-NOV-10. [Details]
(2003) Apoptosis: From Bench to the Bedside,
Logue SE, Szegezdi E, Samali, A (2003) A Characterisation of ER Stress-Induced Apoptosis. [Oral Presentation], Apoptosis: From Bench to the Bedside, Cork , 04-JUN-03 - 06-JUN-03. [Details]

Abstract

  Year Publication
(2011) NERVE GROWTH FACTOR MEDIATES ACTIVE CASPASE-3 TURNOVER IN APOPTOTIC PC12 CELLS.
Carleton, LA,Mnich, K,Kavanagh, ET,Doyle, K,Samali, A,Gorman, AM (2011) NERVE GROWTH FACTOR MEDIATES ACTIVE CASPASE-3 TURNOVER IN APOPTOTIC PC12 CELLS. Abstract [Details]
(2010) Dual Cdc7/Cdk9 kinase inhibitor, PHA-767491, targets both quiescent and proliferating CLL cells.
Santocanale, A,Natoni, A,Murillo, L,Catherwood, M,Montagnoli, A,Samali, A,O'Dwyer, M (2010) Dual Cdc7/Cdk9 kinase inhibitor, PHA-767491, targets both quiescent and proliferating CLL cells. Abstract [Details]
(2010) High Throughput Glycanmap (R) Analysis of Glycosylation during ER Stress and Apoptosis in a Colon Cancer Model.
Gupta, S,Gerlach, J,Miura, Y,Yamazaki, T,Nakahara, T,Asada, H,Samali, A,Joshi, L (2010) High Throughput Glycanmap (R) Analysis of Glycosylation during ER Stress and Apoptosis in a Colon Cancer Model. Abstract [Details]
(2007) Endoplasmic reticulum stress in multiple sclerosis. Neuron Glia Biology.
Mhaille AN, McQuaid S, Windebank A, Cunnea P, McMahon J, Samali A, FitzGerald U. (2007) Endoplasmic reticulum stress in multiple sclerosis. Neuron Glia Biology. Abstract [Details]
(2007) Selective reduction of protein disulfide isomerase (PDI) redox state by TNF-alpha in a cystic fibrosis cell model.
Halvey, PJ,Samali, A,Jones, DP,Stecenko, AA,Hansen, JM (2007) Selective reduction of protein disulfide isomerase (PDI) redox state by TNF-alpha in a cystic fibrosis cell model. Abstract [Details]
(2006) Selective nuclear oxidative stress oxidizes glutathione and inhibits NF-kappa B reporter activity without thioredoxin 1 oxidation.
Halvey, PJ,Hansen, JM,Johnson, JM,Go, YM,Samali, A,Jones, DP (2006) Selective nuclear oxidative stress oxidizes glutathione and inhibits NF-kappa B reporter activity without thioredoxin 1 oxidation. Abstract [Details]
(2005) Transcriptosome profiling of human Coronary Artery Smooth Muscle Cells in response to oxidized Low Density Lipoprotein. Royal Academy of Medicine Ireland, Section of Biomedical Sciences Summer Meeting.
Reeve J, Stenson-Cox C, Porn-Ares I, Ares M, O'Brien T, Samali A (2005) Transcriptosome profiling of human Coronary Artery Smooth Muscle Cells in response to oxidized Low Density Lipoprotein. Royal Academy of Medicine Ireland, Section of Biomedical Sciences Summer Meeting. Abstract [Details]
(2005) Adenoviral-mediated antioxidant overexpression: possible protective role against hyperglycemic conditions in HAEC. American Society for Gene Therapy.
Duffy A, Liew A, Samali A, O' Brien T (2005) Adenoviral-mediated antioxidant overexpression: possible protective role against hyperglycemic conditions in HAEC. American Society for Gene Therapy. Abstract [Details]
(2005) Cytoprotection of RIN cells from Cytokine-Mediated toxicity by gene transfer of anti-apoptotic proteins. Irish Endocrine Society.
Bell M, Conroy S, Ritter T, Houlihan C, Samali A, O' Brien T (2005) Cytoprotection of RIN cells from Cytokine-Mediated toxicity by gene transfer of anti-apoptotic proteins. Irish Endocrine Society. Limerick: Abstract [Details]
(2004) Compartmental oxidation of thiol/disulfide redox couples during EGF signaling.
Halvey, PJ,Watson, WH,Hansen, JM,Go, YM,Samali, A,Jones, DP (2004) Compartmental oxidation of thiol/disulfide redox couples during EGF signaling. Abstract [Details]
(2003) Arsenic trioxide sensitizes leukemic cells to TRAIL-induced apoptosis.
Cahill, S,Szegezdi, E,Samali, A,O'Dwyer, M (2003) Arsenic trioxide sensitizes leukemic cells to TRAIL-induced apoptosis. Abstract [Details]

Editorial

  Year Publication
(2014) Endoplasmic Reticulum Stress: At the Crossroads of Inflammation and Metabolism in Hepatocellular Carcinoma Development.
Maurel, M,Samali, A,Chevet, E (2014) Endoplasmic Reticulum Stress: At the Crossroads of Inflammation and Metabolism in Hepatocellular Carcinoma Development. Editorial [DOI] [Details]
(2010) Cell Stress and Cell Death. International Journal of Cell Biology.
Afshin Samali, Simone Fulda, Adrienne M. Gorman, Osamu Hori, and Srinivasa M. Srinivasula (2010) Cell Stress and Cell Death. International Journal of Cell Biology. Editorial [DOI] [Details]
(2007) Apoptosis: a mapped path to cell death.
Samali, A (2007) Apoptosis: a mapped path to cell death. Editorial [DOI] [Details]
(2007) Apoptosis: a mapped path to cell death.
Samali, A (2007) Apoptosis: a mapped path to cell death. HOBOKEN: WILEY Editorial [DOI] [Details]

Meeting

  Year Publication
(2011) ENHANCEMENT OF ANTITUMOR PROPERTIES OF RHTRAIL BY AFFINITY INCREASE TOWARD ITS DEATH RECEPTORS.
Reis, CR,van der Sloot, AM,Szegezdi, E,Natoni, A,Tur, V,Cool, RH,Samali, A,Serrano, L,Quax, WJ (2011) ENHANCEMENT OF ANTITUMOR PROPERTIES OF RHTRAIL BY AFFINITY INCREASE TOWARD ITS DEATH RECEPTORS. Meeting [Details]
(2011) DESIGNED RECEPTOR SPECIFIC RHTRAIL VARIANTS ENHANCE INDUCTION OF APOPTOSIS IN CANCER CELLS.
Quax, WJ,Reis, CR,van der Sloot, AM,Tur, V,Szegezdi, E,Natoni, A,Cool, RH,Samali, A,Serrano, L (2011) DESIGNED RECEPTOR SPECIFIC RHTRAIL VARIANTS ENHANCE INDUCTION OF APOPTOSIS IN CANCER CELLS. Meeting [Details]
(2011) IMPROVED TUMOR CELL KILLING BY TRAIL REQUIRES SELECTIVE AND HIGH AFFINITY RECEPTOR ACTIVATION.
Szegezdi, E,van der Sloot, AM,Alessandro, N,Mahalingam, D,Cool, RH,Munoz, IG,Montoya, G,Quax, WJ,Serrano, SDL,Samali, A (2011) IMPROVED TUMOR CELL KILLING BY TRAIL REQUIRES SELECTIVE AND HIGH AFFINITY RECEPTOR ACTIVATION. Meeting [Details]
(2010) The BH3 Mimetic, ABT-737, Overcomes Stromal-Mediated Pro-Survival Signals and Synergizes with PHA-767491, a Dual Cdc7/CDK9 Inhibitor, In Acute Myeloid Leukaemia.
Morrell, RC,Szegezdi, E,Halpin-McCormick, A,Cawley, K,Samali, A,O'Dwyer, M (2010) The BH3 Mimetic, ABT-737, Overcomes Stromal-Mediated Pro-Survival Signals and Synergizes with PHA-767491, a Dual Cdc7/CDK9 Inhibitor, In Acute Myeloid Leukaemia. Meeting [Details]
(2010) MECHANISM OF TRAIL RESISTANCE IN NON-TRANSFORMED CELLS.
van Dijk, M,Samali, A,Szegezdi, E (2010) MECHANISM OF TRAIL RESISTANCE IN NON-TRANSFORMED CELLS. Meeting [Details]
(1995) PROGRAMMED CELL-DEATH - MAKING FRIENDS WITH DEATH GENES.
COTTER, TG,FERNANDES, R,SAMALI, A,MCGAHON, A (1995) PROGRAMMED CELL-DEATH - MAKING FRIENDS WITH DEATH GENES. Meeting [Details]

Other Item

  Year Publication
(2007) Apoptosis: a mapped path to cell death. J Cell Mol Med.
Samali, A. (2007) Apoptosis: a mapped path to cell death. J Cell Mol Med. Other Item [Details]
(2007) A tribute to Professor Richard A. Lockshin on his 70th birthday. J Cell Mol Med.
Samali, A. (2007) A tribute to Professor Richard A. Lockshin on his 70th birthday. J Cell Mol Med. Other Item [Details]

Reviews

  Year Publication
(2020) Tumour Cell Secretome in Chemoresistance and Tumour Recurrence.
Madden, EC;Gorman, AM;Logue, SE;Samali, A (2020) Tumour Cell Secretome in Chemoresistance and Tumour Recurrence. CAMBRIDGE: CELL PRESS Reviews [DOI] [Details]
(2019) The role of the unfolded protein response in cancer progression: From oncogenesis to chemoresistance.
Madden, E;Logue, SE;Healy, SJ;Manie, S;Samali, A (2019) The role of the unfolded protein response in cancer progression: From oncogenesis to chemoresistance. HOBOKEN: WILEY Reviews [DOI] [Details]
(2019) Endoplasmic reticulum stress signalling - from basic mechanisms to clinical applications.
Almanza, A;Carlesso, A;Chintha, C;Creedican, S;Doultsinos, D;Leuzzi, B;Luis, A;McCarthy, N;Montibeller, L;More, S;Papaioannou, A;Puschel, F;Sassano, ML;Skoko, J;Agostinis, P;de Belleroche, J;Eriksson, LA;Fulda, S;Gorman, AM;Healy, S;Kozlov, A;Munoz-Pinedo, C;Rehm, M;Chevet, E;Samali, A (2019) Endoplasmic reticulum stress signalling - from basic mechanisms to clinical applications. HOBOKEN: WILEY Reviews [DOI] [Details]
(2018) Glioblastoma and chemoresistance to alkylating agents: Involvement of apoptosis, autophagy, and unfolded protein response.
Hombach-Klonisch, S;Mehrpour, M;Shojaei, S;Harlos, C;Pitz, M;Hamai, A;Siemianowicz, K;Likus, W;Wiechec, E;Toyota, BD;Hoshyar, R;Seyfoori, A;Sepehri, Z;Ande, SR;Khadem, F;Akbari, M;Gorman, AM;Samali, A;Klonisch, T;Ghavami, S (2018) Glioblastoma and chemoresistance to alkylating agents: Involvement of apoptosis, autophagy, and unfolded protein response. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD Reviews [DOI] [Details]
(2017) Regulation of the unfolded protein response by noncoding RNA.
McMahon, M;Samali, A;Chevet, E (2017) Regulation of the unfolded protein response by noncoding RNA. BETHESDA: AMER PHYSIOLOGICAL SOC Reviews [DOI] [Details]
(2015) Endoplasmic Reticulum Stress-Activated Cell Reprogramming in Oncogenesis.
Chevet, E,Hetz, C,Samali, A (2015) Endoplasmic Reticulum Stress-Activated Cell Reprogramming in Oncogenesis. Reviews [DOI] [Details]
(2015) Novel roles of the unfolded protein response in the control of tumor development and aggressiveness.
Dejeans, N,Barroso, K,Fernandez-Zapico, ME,Samali, A,Chevet, E (2015) Novel roles of the unfolded protein response in the control of tumor development and aggressiveness. Reviews [Details]
(2015) Novel roles of the unfolded protein response in the control of tumor development and aggressiveness.
Dejeans, N;Barroso, K;Fernandez-Zapico, ME;Samali, A;Chevet, E (2015) Novel roles of the unfolded protein response in the control of tumor development and aggressiveness. LONDON: ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD Reviews [Details]
(2015) Controlling the unfolded protein response-mediated life and death decisions in cancer.
Maurel, M,McGrath, EP,Mnich, K,Healy, S,Chevet, E,Samali, A (2015) Controlling the unfolded protein response-mediated life and death decisions in cancer. Reviews [DOI] [Details]
(2015) Drugging the unfolded protein response in acute leukemias.
Masouleh, BK,Chevet, E,Panse, J,Jost, E,O'Dwyer, M,Bruemmendorf, TH,Samali, A (2015) Drugging the unfolded protein response in acute leukemias. Reviews [DOI] [Details]
(2014) Addicted to secrete - novel concepts and targets in cancer therapy.
Dejeans, N,Manie, S,Hetz, C,Bard, F,Hupp, T,Agostinis, P,Samali, A,Chevet, E (2014) Addicted to secrete - novel concepts and targets in cancer therapy. Reviews [DOI] [Details]
(2014) Stressed to death - mechanisms of ER stress-induced cell death.
Sovolyova, N;Healy, S;Samali, A;Logue, SE (2014) Stressed to death - mechanisms of ER stress-induced cell death. BERLIN: WALTER DE GRUYTER GMBH Reviews [DOI] [Details]
(2014) Regulation of Apoptosis by Heat Shock Proteins.
Kennedy, D,Jager, R,Mosser, DD,Samali, A (2014) Regulation of Apoptosis by Heat Shock Proteins. Reviews [DOI] [Details]
(2013) Stress-induced self-cannibalism: on the regulation of autophagy by endoplasmic reticulum stress.
Deegan, S;Saveljeva, S;Gorman, AM;Samali, A (2013) Stress-induced self-cannibalism: on the regulation of autophagy by endoplasmic reticulum stress. BASEL: SPRINGER BASEL AG Reviews [DOI] [Details]
(2013) The eIF2 alpha kinases: their structures and functions.
Donnelly, N;Gorman, AM;Gupta, S;Samali, A (2013) The eIF2 alpha kinases: their structures and functions. BASEL: SPRINGER BASEL AG Reviews [DOI] [Details]
(2013) Structural determinants of DISC function: New insights into death receptor-mediated apoptosis signalling.
Sessler, T;Healy, S;Samali, A;Szegezdi, E (2013) Structural determinants of DISC function: New insights into death receptor-mediated apoptosis signalling. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD Reviews [DOI] [Details]
(2013) Endoplasmic Reticulum Stress and the Unfolded Protein Response: Targeting the Achilles Heel of Multiple Myeloma.
Vincenz, L;Jager, R;O'Dwyer, M;Samali, A (2013) Endoplasmic Reticulum Stress and the Unfolded Protein Response: Targeting the Achilles Heel of Multiple Myeloma. PHILADELPHIA: AMER ASSOC CANCER RESEARCH Reviews [DOI] [Details]
(2012) The unfolded protein response at the crossroads of cellular life and death during endoplasmic reticulum stress.
Jager, R;Bertrand, MJM;Gorman, AM;Vandenabeele, P;Samali, A (2012) The unfolded protein response at the crossroads of cellular life and death during endoplasmic reticulum stress. HOBOKEN: WILEY-BLACKWELL Reviews [DOI] [Details]
(2012) The unfolded protein response at the crossroads of cellular life and death during endoplasmic reticulum stress.
Jager, R,Bertrand, MJM,Gorman, AM,Vandenabeele, P,Samali, A (2012) The unfolded protein response at the crossroads of cellular life and death during endoplasmic reticulum stress. Reviews [DOI] [Details]
(2012) Stress management at the ER: Regulators of ER stress-induced apoptosis.
Gorman, AM,Healy, SJM,Jager, R,Samali, A (2012) Stress management at the ER: Regulators of ER stress-induced apoptosis. Reviews [DOI] [Details]
(2012) Stress management at the ER: Regulators of ER stress-induced apoptosis.
Gorman, AM;Healy, SJM;Jager, R;Samali, A (2012) Stress management at the ER: Regulators of ER stress-induced apoptosis. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD Reviews [DOI] [Details]
(2011) Unfolded proteins and Endoplasmic Reticulum stress in neurodegenerative disorders.
Doyle KM, Kennedy D, Gorman AM, Gupta S, Healy SJ, Samali A. (2011) Unfolded proteins and Endoplasmic Reticulum stress in neurodegenerative disorders. Reviews [Details]
(2011) Unfolded proteins and endoplasmic reticulum stress in neurodegenerative disorders.
Doyle, KM,Kennedy, D,Gorman, AM,Gupta, S,Healy, SJM,Samali, A (2011) Unfolded proteins and endoplasmic reticulum stress in neurodegenerative disorders. Reviews [DOI] [Details]
(2009) TRAIL receptor signalling and modulation: Are we on the right TRAIL?.
Mahalingam, D;Szegezdi, E;Keane, M;de Jong, S;Samali, A (2009) TRAIL receptor signalling and modulation: Are we on the right TRAIL?. OXFORD: ELSEVIER SCI LTD Reviews [DOI] [Details]
(2009) Is there a role for nuclear factor kappaB in tumor necrosis factor-related apoptosis-inducing ligand resistance?. Ann N Y Acad Sci.
Plantivaux A, Szegezdi E, Samali A, Egan L. (2009) Is there a role for nuclear factor kappaB in tumor necrosis factor-related apoptosis-inducing ligand resistance?. Ann N Y Acad Sci. Reviews [Details]
(2009) Targeting the endoplasmic reticulum-stress response as an anticancer strategy.
Healy, SZ, Gorman, AM, Mousavi-Shafaei, P, Gupta, S, Samali, A. (2009) Targeting the endoplasmic reticulum-stress response as an anticancer strategy. Reviews [Details]
(2009) Targeting the endoplasmic reticulum-stress response as an anticancer strategy.
Healy, SJM;Gorman, AM;Mousavi-Shafaei, P;Gupta, S;Samali, A (2009) Targeting the endoplasmic reticulum-stress response as an anticancer strategy. AMSTERDAM: ELSEVIER SCIENCE BV Reviews [DOI] [Details]
(2009) Bcl-2 family on guard at the ER.
Szegezdi, E;MacDonald, DC;Chonghaile, TN;Gupta, S;Samali, A (2009) Bcl-2 family on guard at the ER. BETHESDA: AMER PHYSIOLOGICAL SOC Reviews [DOI] [Details]
(2009) TRAIL receptor signalling and modulation: Are we on the right TRAIL?.
Mahalingam, D,Szegezdi, E,Keane, M,de Jong, S,Samali, A (2009) TRAIL receptor signalling and modulation: Are we on the right TRAIL?. Reviews [DOI] [Details]
(2006) Cytoprotection of beta cells: rational gene transfer strategies.
McCabe, C,Samali, A,O'Brien, T (2006) Cytoprotection of beta cells: rational gene transfer strategies. Reviews [DOI] [Details]
(2006) Cytoprotection of beta cells: rational gene transfer strategies. Diabetes Metab Res Rev.
McCabe C, Samali A, O'Brien T (2006) Cytoprotection of beta cells: rational gene transfer strategies. Diabetes Metab Res Rev. Reviews [Details]
(2006) Mediators of endoplasmic reticulum stress-induced apoptosis.
Szegezdi, E,Logue, SE,Gorman, AM,Samali, A (2006) Mediators of endoplasmic reticulum stress-induced apoptosis. Reviews [DOI] [Details]
(2006) Mediators of endoplasmic reticulum stress-induced apoptosis.
Szegezdi, E;Logue, SE;Gorman, AM;Samali, A (2006) Mediators of endoplasmic reticulum stress-induced apoptosis. LONDON: NATURE PUBLISHING GROUP Reviews [DOI] [Details]
(2006) Mediators of endoplasmic reticulum stress-induced apoptosis. EMBO Rep.
Szegezdi E., Logue S.E., Gorman A.M., Samali A. (2006) Mediators of endoplasmic reticulum stress-induced apoptosis. EMBO Rep. Reviews [Details]
(2006) Cytoprotection of beta cells: rational gene transfer strategies.
McCabe, C;Samali, A;O'Brien, T (2006) Cytoprotection of beta cells: rational gene transfer strategies. HOBOKEN: WILEY Reviews [DOI] [Details]
(2005) Don’t Lose Heart – Therapeutic Value of Apoptosis Prevention in the Treatment of Cardiovascular Disease. Journal of Cellular and Molecular Medicine.
O'Brien, T Samali, A, Duffy, AM, Reeve, JL (2005) Don’t Lose Heart – Therapeutic Value of Apoptosis Prevention in the Treatment of Cardiovascular Disease. Journal of Cellular and Molecular Medicine. Reviews [Details]
(2005) Don't lose heart - therapeutic value of apoptosis prevention in the treatment of cardiovascular disease.
Reeve, JLV,Duffy, AM,O'Brien, T,Samali, A (2005) Don't lose heart - therapeutic value of apoptosis prevention in the treatment of cardiovascular disease. Reviews [Details]
(2005) Ischemia/reperfusion injury at the intersection with cell death.
Logue, SE,Gustafsson, AB,Samali, A,Gottlieb, RA (2005) Ischemia/reperfusion injury at the intersection with cell death. Reviews [DOI] [Details]
(2005) Ischemia/Reperfusion injury at the intersection with cell death. Mol. Cell. Cardiol.
Logue S.E., Gustafsson Å.B., Samali A., Gottlieb R.A. (2005) Ischemia/Reperfusion injury at the intersection with cell death. Mol. Cell. Cardiol. Reviews [Details]
(2005) Ischemia/reperfusion injury at the intersection with cell death.
Logue, SE;Gustafsson, AB;Samali, A;Gottlieb, RA (2005) Ischemia/reperfusion injury at the intersection with cell death. OXFORD: ELSEVIER SCI LTD Reviews [DOI] [Details]
(2005) Don't lose heart - therapeutic value of apoptosis prevention in the treatment of cardiovascular disease.
Reeve, JLV;Duffy, AM;O'Brien, T;Samali, A (2005) Don't lose heart - therapeutic value of apoptosis prevention in the treatment of cardiovascular disease. BUCHARESST: CAROL DAVILA UNIV PRESS Reviews [Details]
(2004) The switch from survival responses to apoptosis after chromosomal breaks.
Bree, RT;Neary, C;Samali, A;Lowndes, NF (2004) The switch from survival responses to apoptosis after chromosomal breaks. AMSTERDAM: ELSEVIER SCIENCE BV Reviews [DOI] [Details]
(2004) The switch from DNA repair to apoptosis after chromosomal breaks. DNA Repair.
Bree R.T., Neary C., Samali A., Lowndes N.F. (2004) The switch from DNA repair to apoptosis after chromosomal breaks. DNA Repair. Reviews [Details]
(2004) The switch from survival responses to apoptosis after chromosomal breaks.
Bree, RT,Neary, C,Samali, A,Lowndes, NF (2004) The switch from survival responses to apoptosis after chromosomal breaks. Reviews [DOI] [Details]
(2003) In the cut and thrust of apoptosis, serine proteases come of age. Biochem. Pharmacol.
Stenson-Cox C., FitzGerald U., Samali A. (2003) In the cut and thrust of apoptosis, serine proteases come of age. Biochem. Pharmacol. Reviews [Details]
(2003) On the role of Hsp27 in regulating apoptosis. Apoptosis.
Concannon C.G., Gorman A.M., Samali A. (2003) On the role of Hsp27 in regulating apoptosis. Apoptosis. Reviews [Details]
(2003) Caspase-12 and ER-stress-mediated apoptosis: The story so far. Ann. NY Acad. Sci.
Szegezdi E., FitzGerald U., Samali A. (2003) Caspase-12 and ER-stress-mediated apoptosis: The story so far. Ann. NY Acad. Sci. Reviews [Details]
(2002) Cellular longevity: role of apoptosis and replicative senescence.
Bree, RT,Stenson-Cox, C,Grealy, M,Byrnes, L,Gorman, AM,Samali, A (2002) Cellular longevity: role of apoptosis and replicative senescence. Reviews [Details]
(2002) Cellular longevity: role of apoptosis and replicative senescence.
Bree, RT;Stenson-Cox, C;Grealy, M;Byrnes, L;Gorman, AM;Samali, A (2002) Cellular longevity: role of apoptosis and replicative senescence. NEW YORK: SPRINGER Reviews [Details]
(2002) Cellular longevity: role of apoptosis and replicative senescenece. Biogerontology.
Bree RT, Stenson C, Grealy M, Byrnes L, Gorman AM and Samali A (2002) Cellular longevity: role of apoptosis and replicative senescenece. Biogerontology. Reviews [Details]
(2002) Losing heart: the role of apoptosis in heart disease - a novel therapeutic target?.
Gill, C,Mestril, R,Samali, A (2002) Losing heart: the role of apoptosis in heart disease - a novel therapeutic target?. Reviews [Details]
(2002) Losing heart: the role of apoptosis in heart disease - a novel therapeutic target?.
Gill, C;Mestril, R;Samali, A (2002) Losing heart: the role of apoptosis in heart disease - a novel therapeutic target?. BETHESDA: FEDERATION AMER SOC EXP BIOL Reviews [Details]
(1996) Apoptosis - The story so far .
Samali, A,Gorman, AM,Cotter, TG (1996) Apoptosis - The story so far . Reviews [Details]

Professional Associations

  Association Function From / To
European Cell Death Organisation (ECDO) Member 03-JAN-00 /
Irish Association for Cancer Research Council Member 01-MAR-13 /
Biochemical Society Member 02-FEB-15 /

Patents

  Patent Number Title Granted
US7994281 Improved Cytokine Design 09-AUG-11

Employment

  Employer Position From / To
National University of Ireland, Galway Senior Lecturer 01-JAN-04 / 03-DEC-07
National University of Ireland, Galway Professor 03-DEC-07 /
Karolinska Institute Postdoctoral Researcher 01-APR-97 / 31-DEC-99
National University of Ireland, Galway Lecturer 01-JAN-00 / 30-AUG-04

Education

  Year Institution Qualification Subject
1997 University College Cork PhD Biochemistry
1993 National University of Ireland, Maynooth BSc Biology

Languages

  Language
Persian
English
Spanish

Internal Collaborators

  Name Description of Collaboration
Internal Collaborators
Dr. Adrienne M Gorman, Apoptosis Research Centre, NUI GalwayDr. Eva Szegezdi, Apoptosis Research Centre, NUI GalwayProf. Michael O'Dwyer, Apoptosis Research Centre, NUI GalwayProf. Lokesh Joshi, AGRC, NUI GalwayProf. Matthew Griffin, REMEDI, NUI GalwayDr. Aoife Boyd, Microbiology, School of Natural Sciences 

External Collaborators

  Name Organisation / Institute Country Description of Collaboration
External Collaborators
Prof. Peter Vandenabeele, VIB/Ghent University, BelgiumProf. Matheiu Bertrand, VIB/Ghent University, BelgiumProf. Patrizia Agostinis VIB/Ghent University, BelgiumProf. Sarah Gerlo, VIB/Ghent University, BelgiumProf. Claudio Hetz, University of Chile, Santiago, ChileProf. Andrey Kozlov, Boltzmann Institute fur Experimentelle und Klinische Traumatologie, Vienna, AustiaDr. Eric Chevet, INSERM, Rennes, France