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Biological and Chemical Sciences

Prof Adrienne Gorman

BA (MOD) Biochemistry, PhD Biochemistry

Contact Details

Personal Professor
School of Biological and Chemica
Biomedical Sciences building
Upper Newcastle Road
University of Galway
T: Ext. 2417
E: adrienne.gorman@nuigalway.ie
 
researcher
 

Biography

Education and qualifications
BA(Mod) Biochemistry Trinity College Dublin
PhD Biochemistry Trinity College Dublin

Appointments
Personal Professor, Biochemistry, NUI Galway, 2019-present
Senior Lecturer, Biochemistry, NUI Galway, 2017-2019
Vice-Dean for Research in College of Science, 2013-2018
Lecturer in Biochemistry, NUI Galway, 2000-2017
Post-doctoral research fellow, Karolinska Institutet, Stockholm Sweden
Post-doctoral researcher, University College Cork, Ireland
Marie Curie Post-doctoral research fellow, University of St Andrews, Scotland

Research Interests
Cell stress response pathways; Cell stress and cell death; Cell survival mechanisms; Endoplasmic reticulum stress; Unfolded protein response; IRE1; Cancer; Triple negative breast cancer  

Peer Reviewed Journals

  Year Publication
(2023) 'Endoplasmic Reticulum Stress-Regulated Chaperones as a Serum Biomarker Panel for Parkinson's Disease'
Mnich, K.,Moghaddam, S.,Browne, P.,Counihan, T.,Fitzgerald, S. P.,Martin, K.,Richardson, C.,Samali, A.,Gorman, A. M. (2023) 'Endoplasmic Reticulum Stress-Regulated Chaperones as a Serum Biomarker Panel for Parkinson's Disease'. Mol Neurobiol, 60 (33):1476-1485 [Details]
(2022) 'Regulated IRE1α-dependent decay (RIDD)-mediated reprograming of lipid metabolism in cancer'
Almanza, A.,Mnich, K.,Blomme, A.,Robinson, C. M.,Rodriguez-Blanco, G.,Kierszniowska, S.,McGrath, E. P.,Le Gallo, M.,Pilalis, E.,Swinnen, J. V.,Chatziioannou, A.,Chevet, E.,Gorman, A. M.,Samali, A. (2022) 'Regulated IRE1α-dependent decay (RIDD)-mediated reprograming of lipid metabolism in cancer'. Nat Commun, 13 (11) [Details]
(2022) 'Inhibition of IRE1α RNase activity sensitizes patient-derived acute myeloid leukaemia cells to proteasome inhibitors'
Creedican, S.,Robinson, C. M.,Mnich, K.,Islam, M. N.,Szegezdi, E.,Clifford, R.,Krawczyk, J.,Patterson, J. B.,FitzGerald, S. P.,Summers, M.,Richardson, C.,Martin, K.,Gorman, A. M.,Samali, A. (2022) 'Inhibition of IRE1α RNase activity sensitizes patient-derived acute myeloid leukaemia cells to proteasome inhibitors'. J Cell Mol Med, 26 (1616):4629-4633 [Details]
(2022) 'New insights into IRE1α activation and function in anti-tumor immunity'
Logue, S. E.,Gorman, A. M.,Samali, A. (2022) 'New insights into IRE1α activation and function in anti-tumor immunity'. J Cell Biol, 221 (66) [Details]
(2021) 'Functional traits reveal the dominant drivers of long-term community change across a North American Great Lake'
Sinclair, J. S.,Fraker, M. E.,Hood, J. M.,Frank, K. T.,DuFour, M. R.,Gorman, A. M.,Ludsin, S. A. (2021) 'Functional traits reveal the dominant drivers of long-term community change across a North American Great Lake'. Glob Chang Biol, 27 (2323):6232-6251 [Details]
(2021) 'An Emerging Role for the Unfolded Protein Response in Pancreatic Cancer'
Robinson, C. M.,Talty, A.,Logue, S. E.,Mnich, K.,Gorman, A. M.,Samali, A. (2021) 'An Emerging Role for the Unfolded Protein Response in Pancreatic Cancer'. Cancers (Basel), 13 (22) [Details]
(2021) 'Regulation of lipid metabolism by the unfolded protein response'
Moncan, M.,Mnich, K.,Blomme, A.,Almanza, A.,Samali, A.,Gorman, A. M. (2021) 'Regulation of lipid metabolism by the unfolded protein response'. J Cell Mol Med, 25 (33):1359-1370 [Details]
(2021) 'The stressosome, a caspase-8-activating signalling complex assembled in response to cell stress in an ATG5-mediated manner'
Mnich, K.,Koryga, I.,Pakos-Zebrucka, K.,Thomas, M.,Logue, S. E.,Eriksson, L. A.,Gorman, A. M.,Samali, A. (2021) 'The stressosome, a caspase-8-activating signalling complex assembled in response to cell stress in an ATG5-mediated manner'. J Cell Mol Med, 25 (1818):8809-8820 [Details]
(2020) 'Molecular modeling provides a structural basis for PERK inhibitor selectivity towards RIPK1'
Chintha, C,Carlesso, A,Gorman, AM,Samali, A,Eriksson, LA (2020) 'Molecular modeling provides a structural basis for PERK inhibitor selectivity towards RIPK1'. Rsc Advances, 10 :367-375 [DOI] [Details]
(2020) 'The IRE1 and PERK arms of the unfolded protein response promote survival of rhabdomyosarcoma cells'
McCarthy, N;Dolgikh, N;Logue, S;Patterson, JB;Zeng, QP;Gorman, AM;Samali, A;Fulda, S (2020) 'The IRE1 and PERK arms of the unfolded protein response promote survival of rhabdomyosarcoma cells'. Cancer Letters, 490 :76-88 [DOI] [Details]
(2020) 'Time and region-dependent manner of increased brain derived neurotrophic factor and TrkB in rat brain after binge-like methamphetamine exposure'
Moreira da Silva Santos A, Gorman AM, Kelly JP, Doyle KM (2020) 'Time and region-dependent manner of increased brain derived neurotrophic factor and TrkB in rat brain after binge-like methamphetamine exposure'. Neuroscience Letters, [ARAN Link] [Details]
(2020) 'Novel Pt(IV) prodrugs displaying antimitochondrial effects'
Tabrizi, L.; Thompson, K.; Mnich, K.; Chintha, C.; Gorman, A.; Morrison, L.; Luessing, J.; Lowndes, N.; Dockery, P.; Samali, A.; Erxleben, A. (2020) 'Novel Pt(IV) prodrugs displaying antimitochondrial effects'. Molecular Pharmaceutics, [Details]
(2020) 'Local intracerebral inhibition of IRE1 by MKC8866 sensitizes glioblastoma to irradiation/chemotherapy in vivo'
Le Reste, PJ;Pineau, R;Voutetakis, K;Samal, J;Jegou, G;Lhomond, S;Gorman, AM;Samali, A;Patterson, JB;Zeng, QP;Pandit, A;Aubry, M;Soriano, N;Etcheverry, A;Chatziioannou, A;Mosser, J;Avril, T;Chevet, E (2020) 'Local intracerebral inhibition of IRE1 by MKC8866 sensitizes glioblastoma to irradiation/chemotherapy in vivo'. Cancer Letters, 494 :73-83 [DOI] [Details]
(2020) 'Correction: Inhibition of IRE1α RNase activity reduces NLRP3 inflammasome assembly and processing of pro-IL1β'
Talty, A.,Deegan, S.,Ljujic, M.,Mnich, K.,Naicker, S. D.,Quandt, D.,Zeng, Q.,Patterson, J. B.,Gorman, A. M.,Griffin, M. D.,Samali, A.,Logue, S. E. (2020) 'Correction: Inhibition of IRE1α RNase activity reduces NLRP3 inflammasome assembly and processing of pro-IL1β'. Cell Death Dis, 11 (11) [Details]
(2020) 'Tumour Cell Secretome in Chemoresistance and Tumour Recurrence'
Madden, E. C.,Gorman, A. M.,Logue, S. E.,Samali, A. (2020) 'Tumour Cell Secretome in Chemoresistance and Tumour Recurrence'. Trends Cancer, 6 (66):489-505 [Details]
(2019) 'Endoplasmic reticulum stress signalling - from basic mechanisms to clinical applications'
Almanza, A.,Carlesso, A.,Chintha, C.,Creedican, S.,Doultsinos, D.,Leuzzi, B.,Luís, A.,McCarthy, N.,Montibeller, L.,More, S.,Papaioannou, A.,Püschel, F.,Sassano, M. L.,Skoko, J.,Agostinis, P.,de Belleroche, J.,Eriksson, L. A.,Fulda, S.,Gorman, A. M.,Healy, S.,Kozlov, A.,Muñoz-Pinedo, C.,Rehm, M.,Chevet, E.,Samali, A. (2019) 'Endoplasmic reticulum stress signalling - from basic mechanisms to clinical applications'. Febs j, 286 (22):241-278 [Details]
(2019) 'Effect of Kinase Inhibiting RNase Attenuator (KIRA) Compounds on the Formation of Face-to-Face Dimers of Inositol-Requiring Enzyme 1: Insights from Computational Modeling'
Carlesso, A.,Chintha, C.,Gorman, A. M.,Samali, A.,Eriksson, L. A. (2019) 'Effect of Kinase Inhibiting RNase Attenuator (KIRA) Compounds on the Formation of Face-to-Face Dimers of Inositol-Requiring Enzyme 1: Insights from Computational Modeling'. Int J Mol Sci, 20 (2222) [Details]
(2019) 'Merits and pitfalls of conventional and covalent docking in identifying new hydroxyl aryl aldehyde like compounds as human IRE1 inhibitors'
Carlesso, A,Chintha, C,Gorman, AM,Samali, A,Eriksson, LA (2019) 'Merits and pitfalls of conventional and covalent docking in identifying new hydroxyl aryl aldehyde like compounds as human IRE1 inhibitors'. Scientific Reports, 9 [DOI] [Details]
(2019) 'Crosstalk between inflammatory mediators and endoplasmic reticulum stress in liver diseases'
Duvigneau, J. C.,Luís, A.,Gorman, A. M.,Samali, A.,Kaltenecker, D.,Moriggl, R.,Kozlov, A. V. (2019) 'Crosstalk between inflammatory mediators and endoplasmic reticulum stress in liver diseases'. Cytokine, 124 [Details]
(2019) 'Application of a New Multiplexed Array for Rapid, Sensitive, Simultaneous and Quantitative Assessment of Spliced and Unspliced XBP1'
Creedican, S.,Talty, A.,Fitzgerald, S. P.,Samali, A.,Richardson, C.,Gorman, A. M.,Martin, K. (2019) 'Application of a New Multiplexed Array for Rapid, Sensitive, Simultaneous and Quantitative Assessment of Spliced and Unspliced XBP1'. Biol Proced Online, 21 [Details]
(2019) 'Inhibition of IRE1 alpha RNase activity reduces NLRP3 inflammasome assembly and processing of pro-IL1 beta'
Talty, A,Deegan, S,Ljujic, M,Mnich, K,Naicker, SD,Quandt, D,Zeng, QP,Patterson, JB,Gorman, AM,Griffin, MD,Samali, A,Logue, SE (2019) 'Inhibition of IRE1 alpha RNase activity reduces NLRP3 inflammasome assembly and processing of pro-IL1 beta'. Cell Death & Disease, 10 [DOI] [Details]
(2018) 'Binding Analysis of the Inositol-Requiring Enzyme 1 Kinase Domain'
Carlesso, A.,Chintha, C.,Gorman, A. M.,Samali, A.,Eriksson, L. A. (2018) 'Binding Analysis of the Inositol-Requiring Enzyme 1 Kinase Domain'. ACS Omega, 3 (1010):13313-13322 [Details]
(2018) 'Inhibition of IRE1 RNase activity modulates the tumor cell secretome and enhances response to chemotherapy'
Logue SE, McGrath EP, Cleary P, Greene S, Mnich K, Almanza A, Chevet E, Dwyer RM, Oommen A, Legembre P, Godey F, Madden EC, Leuzzi B, Obacz J, Zeng Q, Patterson JB, Jäger R, Gorman AM, Samali A (2018) 'Inhibition of IRE1 RNase activity modulates the tumor cell secretome and enhances response to chemotherapy'. Nature Communications, 9 [DOI] [Details]
(2018) 'The Unfolded Protein Response in Breast Cancer'
McGrath, E. P.,Logue, S. E.,Mnich, K.,Deegan, S.,Jäger, R.,Gorman, A. M.,Samali, A. (2018) 'The Unfolded Protein Response in Breast Cancer'. Cancers (Basel), 10 (1010) [Details]
(2018) 'Glioblastoma and chemoresistance to alkylating agents: Involvement of apoptosis, autophagy, and unfolded protein response'
Hombach-Klonisch, S.,Mehrpour, M.,Shojaei, S.,Harlos, C.,Pitz, M.,Hamai, A.,Siemianowicz, K.,Likus, W.,Wiechec, E.,Toyota, B. D.,Hoshyar, R.,Seyfoori, A.,Sepehri, Z.,Ande, S. R.,Khadem, F.,Akbari, M.,Gorman, A. M.,Samali, A.,Klonisch, T.,Ghavami, S. (2018) 'Glioblastoma and chemoresistance to alkylating agents: Involvement of apoptosis, autophagy, and unfolded protein response'. Pharmacol Ther, 184 :13-41 [Details]
(2018) 'RIP2 enhances cell survival by activation of NF-kappa B in triple negative breast cancer cells'
Jaafar, R,Mnich, K,Dolan, S,Hillis, J,Almanza, A,Logue, SE,Samali, A,Gorman, AM (2018) 'RIP2 enhances cell survival by activation of NF-kappa B in triple negative breast cancer cells'. Biochemical And Biophysical Research Communications, 497 :115-121 [DOI] [ARAN Link] [Details]
(2017) 'HSPB1 facilitates ERK-mediated phosphorylation and degradation of BIM to attenuate endoplasmic reticulum stress-induced apoptosis'
Kennedy, D,Mnich, K,Oommen, D,Chakravarthy, R,Almeida-Souza, L,Krols, M,Saveljeva, S,Doyle, K,Gupta, S,Timmerman, V,Janssens, S,Gorman, AM,Samali, A (2017) 'HSPB1 facilitates ERK-mediated phosphorylation and degradation of BIM to attenuate endoplasmic reticulum stress-induced apoptosis'. Cell Death & Disease, 8 [DOI] [Details]
(2017) 'Homology model of the human tRNA splicing ligase RtcB'
Nandy, A,Saenz-Mendez, P,Gorman, AM,Samali, A,Eriksson, LA (2017) 'Homology model of the human tRNA splicing ligase RtcB'. Proteins, 85 :1983-1993 [DOI] [Details]
(2017) 'Generation of rationally-designed nerve growth factor (NGF) variants with receptor specificity'
Carleton LA, Chakravarthy R, van der Sloot AM, Mnich K, Serrano L, Samali A, Gorman AM. (2017) 'Generation of rationally-designed nerve growth factor (NGF) variants with receptor specificity'. Biochemical And Biophysical Research Communications, [DOI] [ARAN Link] [Details]
(2016) 'The integrated stress response'
Pakos-Zebrucka K;Koryga I;Mnich K;Ljujic M;Samali A;Gorman AM; (2016) 'The integrated stress response'. Embo Reports, 17 (10) [DOI] [ARAN Link] [Details]
(2016) 'Nerve growth factor (NGF)-mediated regulation of p75(NTR) expression contributes to chemotherapeutic resistance in triple negative breast cancer cells'
Chakravarthy R;Mnich K;Gorman AM; (2016) 'Nerve growth factor (NGF)-mediated regulation of p75(NTR) expression contributes to chemotherapeutic resistance in triple negative breast cancer cells'. Biochemical And Biophysical Research Communications, 478 (4) [DOI] [ARAN Link] [Details]
(2016) 'Targeting the angio-proteostasis network: Combining the forces against cancer'
Devisscher, L;Vieri, M;Logue, SE;Panse, J;Geerts, A;Van Vlierberghe, H;Chevet, E;Gorman, AM;Samali, A;Masouleh, BK (2016) 'Targeting the angio-proteostasis network: Combining the forces against cancer'. Pharmacology & Therapeutics, 167 :1-12 [DOI] [Details]
(2016) 'Neurotrophins and B-cell malignancies'
Hillis, J,O'Dwyer, M,Gorman, AM (2016) 'Neurotrophins and B-cell malignancies'. Cell Mol Life Sci, 73 :41-56 [DOI] [Details]
(2016) 'Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)'
Klionsky DJ;Abdelmohsen K;Abe A et al. (2016) 'Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)'. Autophagy, 12 (1) [DOI] [Details]
(2015) 'A close connection between the PERK and IRE arms of the UPR and the transcriptional regulation of autophagy'
Deegan, S,Koryga, I,Glynn, SA,Gupta, S,Gorman, AM,Samali, A (2015) 'A close connection between the PERK and IRE arms of the UPR and the transcriptional regulation of autophagy'. Biochemical And Biophysical Research Communications, 456 :305-311 [DOI] [Details]
(2014) 'Nerve growth factor-mediated inhibition of apoptosis post-caspase activation is due to removal of active caspase-3 in a lysosome-dependent manner'
Mnich, K,Carleton, LA,Kavanagh, ET,Doyle, KM,Samali, A,Gorman, AM (2014) 'Nerve growth factor-mediated inhibition of apoptosis post-caspase activation is due to removal of active caspase-3 in a lysosome-dependent manner'. Cell Death & Disease, 5 [DOI] [ARAN Link] [Details]
(2014) 'Heat Shock Protein 70 Reduces alpha-Synuclein-Induced Predegenerative Neuronal Dystrophy in the alpha-Synuclein Viral Gene Transfer Rat Model of Parkinson's Disease'
Moloney, TC;Hyland, R;O'Toole, D;Paucard, A;Kirik, D;O'Doherty, A;Gorman, AM;Dowd, E (2014) 'Heat Shock Protein 70 Reduces alpha-Synuclein-Induced Predegenerative Neuronal Dystrophy in the alpha-Synuclein Viral Gene Transfer Rat Model of Parkinson's Disease'. Cns Neuroscience & Therapeutics, 20 :50-58 [DOI] [Details]
(2013) 'The eIF2 alpha kinases: their structures and functions'
Donnelly, N,Gorman, AM,Gupta, S,Samali, A (2013) 'The eIF2 alpha kinases: their structures and functions'. Cell Mol Life Sci, 70 :3493-3511 [DOI] [Details]
(2013) 'Disruption of microRNA biogenesis confers resistance to ER stress-induced cell death upstream of the mitochondrion'
Cawley K;Logue SE;Gorman AM;Zeng Q;Patterson J;Gupta S;Samali A; (2013) 'Disruption of microRNA biogenesis confers resistance to ER stress-induced cell death upstream of the mitochondrion'. Plos One, 8 (8) [DOI] [Details]
(2013) 'Stress-induced self-cannibalism: on the regulation of autophagy by endoplasmic reticulum stress'
Deegan S, Saveljeva S, Gorman AM, Samali A (2013) 'Stress-induced self-cannibalism: on the regulation of autophagy by endoplasmic reticulum stress'. Cellular And Molecular Life Sciences, 70 (14):2425-2441 [DOI] [Details]
(2013) 'Current concepts in ER stress-induced apoptosis'
13. Logue SE, Gorman AM, Cleary P, Keogh N, Samali A (2013) 'Current concepts in ER stress-induced apoptosis'. Journal of Carcinogenesis & Mutagenesis, S6 :1-7 [DOI] [Details]
(2013) 'The novel toluidine sulphonamide EL102 shows pre-clinical in vitro and in vivo activity against prostate cancer and circumvents MDR1 resistance'
Toner, AP;McLaughlin, F;Giles, FJ;Sullivan, FJ;O'Connell, E;Carleton, LA;Breen, L;Dunne, G;Gorman, AM;Lewis, JD;Glynn, SA (2013) 'The novel toluidine sulphonamide EL102 shows pre-clinical in vitro and in vivo activity against prostate cancer and circumvents MDR1 resistance'. British Journal Of Cancer, 109 :2131-2141 [DOI] [Details]
(2012) 'The unfolded protein response at the crossroads of cellular life and death during endoplasmic reticulum stress'
Jäger R, Bertrand MJ, Gorman AM, Vandenabeele P, Samali A (2012) 'The unfolded protein response at the crossroads of cellular life and death during endoplasmic reticulum stress'. Biology of the Cell, 104 (5):259-270 [DOI] [Details]
(2012) 'Stress management at the ER: regulators of ER stress-induced apoptosis'
Gorman AM, Healy SJ, Jäger R, Samali A (2012) 'Stress management at the ER: regulators of ER stress-induced apoptosis'. Pharmacology & therapeutics, 134 (3):306-316 [DOI] [ARAN Link] [Details]
(2011) 'Unfolded proteins and endoplasmic reticulum stress in neurodegenerative disorders'
Doyle KM, Kennedy D, Gorman AM, Gupta S, Healy SJ, Samali A (2011) 'Unfolded proteins and endoplasmic reticulum stress in neurodegenerative disorders'. Journal Of Cellular And Molecular Medicine, 15 (10):2025-2039 [DOI] [Details]
(2011) 'Nerve growth factor in cancer cell death and survival'
Molloy NH, Read DE, Gorman AM (2011) 'Nerve growth factor in cancer cell death and survival'. Cancers, 3 :510-530 [ARAN Link] [Details]
(2010) 'The effects of cannabinoid drugs on abnormal involuntary movements in dyskinetic and non-dyskinetic 6-hydroxydopamine lesioned rats'
Walsh, S;Gorman, AM;Finn, DP;Dowd, E (2010) 'The effects of cannabinoid drugs on abnormal involuntary movements in dyskinetic and non-dyskinetic 6-hydroxydopamine lesioned rats'. Brain Research, 1363 :40-48 [DOI] [Details]
(2010) 'Loss of cannabinoid CB1 receptor expression in the 6-hydroxydopamine-induced nigrostriatal terminal lesion model of Parkinson's disease in the rat'
Walsh, S;Mnich, K;Mackie, K;Gorman, AM;Finn, DP;Dowd, E (2010) 'Loss of cannabinoid CB1 receptor expression in the 6-hydroxydopamine-induced nigrostriatal terminal lesion model of Parkinson's disease in the rat'. Brain Research Bulletin, 81 :543-548 [DOI] [Details]
(2010) 'The effect of laminin peptide gradient in enzymatically cross-linked collagen scaffolds on neurite growth'
Yao, L;Damodaran, G;Nikolskaya, N;Gorman, AM;Windebank, A;Pandit, A (2010) 'The effect of laminin peptide gradient in enzymatically cross-linked collagen scaffolds on neurite growth'. Journal Of Biomedical Materials Research Part A, 92A :484-492 [DOI] [Details]
(2010) 'The effect of laminin gradient of enzymatically cross-linked collagen scaffold on neurite growth'
Yao L, Damodaran G, Nikolskaya N, Gorman AM, Windebank A, Pandit A (2010) 'The effect of laminin gradient of enzymatically cross-linked collagen scaffold on neurite growth'. J Biomedical Materials Res, 92 :484-492 [Details]
(2010) 'Cell stress and cell death'
Samali A, Fulda S, Gorman AM, Hori O, Srinivasula SM. (2010) 'Cell stress and cell death'. Int J Cell Biol, 2010 :245803-2pp [Details]
(2010) 'Inhibition by anandamide of 6-hydroxydopamine-induced cell death in PC12 cells'
Mnich, K., Finn, D., Dowd, E., & Gorman, A. (2010) 'Inhibition by anandamide of 6-hydroxydopamine-induced cell death in PC12 cells'. International Journal Of Cell Biology, 818497 [ARAN Link] [Details]
(2010) 'Cellular Stress Responses: cell survival and cell death'
Fulda S, Gorman AM, Hori O, Samali A. (2010) 'Cellular Stress Responses: cell survival and cell death'. Int J Cell Biol, [DOI] [Details]
(2009) 'Involvement of Akt in neurite outgrowth'
Read DE, Gorman AM (2009) 'Involvement of Akt in neurite outgrowth'. Cell Mol Life Sci, 66 :2975-2984 [Details]
(2009) 'Targeting the endoplasmic reticulum-stress response as an anticancer strategy'
Healy, SJM,Gorman, AM,Mousavi-Shafaei, P,Gupta, S,Samali, A (2009) 'Targeting the endoplasmic reticulum-stress response as an anticancer strategy'. European Journal Of Pharmacology, 625 :234-246 [DOI] [Details]
(2009) 'Considerations and recent advances in neuroscience'
Gorman, A. M.,Doyle, K. M. (2009) 'Considerations and recent advances in neuroscience'. Biochemical Society Transactions, 37 :299-302 [Details]
(2009) 'Heat shock protein 27 in neuronal survival and neurite outgrowth'
Read, D. E.,Gorman, A. M. (2009) 'Heat shock protein 27 in neuronal survival and neurite outgrowth'. Biochemical And Biomedical Research Communications, 382 (11):6-8 [Details]
(2009) 'Effect of functionalized micropatterned PLGA on guided neurite growth'
Yao, L;Wang, SG;Cui, WJ;Sherlock, R;O'Connell, C;Damodaran, G;Gorman, A;Windebank, A;Pandit, A (2009) 'Effect of functionalized micropatterned PLGA on guided neurite growth'. Acta Biomaterialia, 5 :580-588 [DOI] [Details]
(2008) 'Nerve growth factor blocks thapsigargin-induced apoptosis at the level of the mitochondrion via regulation of Bim'
Szegezdi E, Herbert KR, Kavanagh ET, Samali A, Gorman AM (2008) 'Nerve growth factor blocks thapsigargin-induced apoptosis at the level of the mitochondrion via regulation of Bim'. Journal Of Cellular And Molecular Medicine, 12 (6A):2482-2496 [DOI] [Details]
(2008) 'Neuronal cell death in neurodegenerative diseases: recurring themes around protein handling'
Gorman AM (2008) 'Neuronal cell death in neurodegenerative diseases: recurring themes around protein handling'. J Cell Mol Med, 12 :2263-2280 [ARAN Link] [Details]
(2008) 'Heat shock enhances NGF-induced neurite elongation which is not mediated by Hsp25 in PC12 cells'
Read, DE;Herbert, KR;Gorman, AM (2008) 'Heat shock enhances NGF-induced neurite elongation which is not mediated by Hsp25 in PC12 cells'. Brain Research, 1221 :14-23 [DOI] [Details]
(2006) 'Mediators of endoplasmic reticulum stress-induced apoptosis'
Szegezdi E, Logue SE, Gorman AM, Samali A (2006) 'Mediators of endoplasmic reticulum stress-induced apoptosis'. Embo Reports, 7 (9):880-885 [DOI] [Details]
(2006) 'Dexamethasone inhibits apoptosis in C6 glioma cells through increased expression of Bcl-X-L'
Ni Chonghaile, T,Concannon, CG,Szegezdi, E,Gorman, AM,Samali, A (2006) 'Dexamethasone inhibits apoptosis in C6 glioma cells through increased expression of Bcl-X-L'. Apoptosis, 11 :1247-1255 [DOI] [Details]
(2006) 'Functionality of NGF-protected PC12 cells following exposure to 6-hydroxydopamine'
Kavanagh ET, Loughlin JP, Herbert KR, Dockery P, Samali A, Doyle KM, Gorman AM (2006) 'Functionality of NGF-protected PC12 cells following exposure to 6-hydroxydopamine'. Biochem, 351 (4):890-895 [DOI] [Details]
(2005) 'Hsp27 inhibits 6-hydroxydopamine-induced cytochrome c release and apoptosis in PC12 cells'
Gorman AM, Szegezdi E, Quigney DJ, Samali A (2005) 'Hsp27 inhibits 6-hydroxydopamine-induced cytochrome c release and apoptosis in PC12 cells'. Biochem, 327 (3):801-810 [DOI] [Details]
(2005) '6-Hydroxydopamine induces both apoptosis and heat shock response in PC12 cells: role of hsp27 in protection against apoptosis'
Gorman A.M., Szegezdi E., Quigney D., Samali A. (2005) '6-Hydroxydopamine induces both apoptosis and heat shock response in PC12 cells: role of hsp27 in protection against apoptosis'. Biochem. Biophys. Res. Commun, 327 :801-810 [Details]
(2005) 'Hypoxia induces neurite outgrowth in PC12 cells that is mediated through adenosine A2A receptors'
O'Driscoll, CM;Gorman, AM (2005) 'Hypoxia induces neurite outgrowth in PC12 cells that is mediated through adenosine A2A receptors'. Neuroscience, 131 :321-329 [Details]
(2003) 'On the role of Hsp27 in regulating apoptosis'
Concannon CG, Gorman AM, Samali A (2003) 'On the role of Hsp27 in regulating apoptosis'. Apoptosis, 8 :61-70 [Details]
(2003) 'Heat shock protects PC12 cells against MPP+ toxicity'
Quigney, DJ,Gorman, AM,Samali, A (2003) 'Heat shock protects PC12 cells against MPP+ toxicity'. Brain Research, 993 :133-139 [DOI] [Details]
(2002) 'Cellular longevity: role of apoptosis and replicative senescence'
Bree RT Stenson C Grealy M Byrnes L Gorman AM Samali A (2002) 'Cellular longevity: role of apoptosis and replicative senescence'. Biogerontology, 3 :195-206 [Details]
(2002) 'Involvement of caspase-3 in photoreceptor cell apoptosis induced by in vivo blue light exposure'
Wu, JM;Gorman, A;Zhou, XH;Sandra, C;Chen, E (2002) 'Involvement of caspase-3 in photoreceptor cell apoptosis induced by in vivo blue light exposure'. Investigative Ophthalmology & Visual Science, 43 :3349-3354 [Details]
(2001) 'Apoptotic morphology does not always require caspase activity in rat cerebellar granule neurons'
Dare, E,Gorman, AM,Ahlbom, E,Gotz, M,Momoi, T,Ceccatelli, S (2001) 'Apoptotic morphology does not always require caspase activity in rat cerebellar granule neurons'. Neurotoxicity research, 3 :501-514 [DOI] [Details]
(2000) 'Dexamethasone pre-treatment interferes with apoptotic death in glioma cells'
Gorman AM, Hirt UA, Orrenius S, Ceccatelli S. (2000) 'Dexamethasone pre-treatment interferes with apoptotic death in glioma cells'. Neurosci, 96 :417-425 [Details]
(2000) 'Role of mitochondria in neuronal apoptosis'
Gorman AM, Ceccatelli S, Orrenius S. (2000) 'Role of mitochondria in neuronal apoptosis'. Developmental Neuroscience, 22 :348-358 [ARAN Link] [Details]
(1999) 'Cytochrome c release and caspase-3 activation during colchicine-induced apoptosis of cerebellar granule cells'
Gorman A, Bonfoco E, Zhivotovsky B, Orrenius S, Ceccatelli S. (1999) 'Cytochrome c release and caspase-3 activation during colchicine-induced apoptosis of cerebellar granule cells'. Eur. J. Neurosci, 11 :1067-1073 [Details]
(1999) 'Application of a fluorometric assay to detect caspase activity in thymus tissue undergoing apoptosis in vivo'
Gorman AM, Hirt UA, Orrenius S, Ceccatelli S. (1999) 'Application of a fluorometric assay to detect caspase activity in thymus tissue undergoing apoptosis in vivo'. J. Immunol. Methods, 226 :43-48 [Details]
(1999) 'Antioxidant-mediated inhibition of the heat shock response leads to apoptosis'
Gorman, AM,Heavey, B,Creagh, E,Cotter, TG,Samali, A (1999) 'Antioxidant-mediated inhibition of the heat shock response leads to apoptosis'. Febs Letters, 445 :98-102 [Details]
(1998) 'Apoptosis in neuronal cells: Role of caspases'
Gorman A, Orrenius S, Ceccatelli S. (1998) 'Apoptosis in neuronal cells: Role of caspases'. NeuroReport, 9 :R49-R55 [Details]
(1997) 'Role of peroxide and superoxide anion during tumour cell apoptosis'
Gorman, A,McGowan, A,Cotter, TG (1997) 'Role of peroxide and superoxide anion during tumour cell apoptosis'. Febs Letters, 404 :27-33 [Details]
(1997) 'Use of flow cytometry techniques in studying mechanisms of apoptosis in leukemic cells'
Gorman, AM,Samali, A,McGowan, AJ,Cotter, TG (1997) 'Use of flow cytometry techniques in studying mechanisms of apoptosis in leukemic cells'. Cytometry, 29 :97-105 [Details]
(1997) 'Role of Bcr-Abl kinase in resistance to apoptosis'
Samali A, Gorman AM, Cotter TG (1997) 'Role of Bcr-Abl kinase in resistance to apoptosis'. Advances in pharmacology (San Diego, Calif.), 41 :533-552 [Details]
(1996) 'Apoptosis -- the story so far'
Samali A, Gorman AM, Cotter TG (1996) 'Apoptosis -- the story so far'. Experientia, 52 (10-11):933-941 [Details]
(1996) 'Reactive oxygen intermediate(s) (ROI): Common mediator(s) of poly(ADP-ribose)polymerase (PARP) cleavage and apoptosis'
McGowan, AJ,RuizRuiz, MC,Gorman, AM,LopezRivas, A,Cotter, TG (1996) 'Reactive oxygen intermediate(s) (ROI): Common mediator(s) of poly(ADP-ribose)polymerase (PARP) cleavage and apoptosis'. Febs Letters, 392 :299-303 [Details]
(1996) 'The role of proteases, PARP and free radicals during apoptosis of several leukemic cell lines'
McGowan A, Ruiz-Ruiz MC, Gorman A, Lopez-Rivas A, Cotter TG. (1996) 'The role of proteases, PARP and free radicals during apoptosis of several leukemic cell lines'. FEBS Lett, 392 :299-303 [Details]
(1996) 'Oxidative stress and apoptosis in neurodegeneration'
Gorman A, McGowan A, Cotter TG. (1996) 'Oxidative stress and apoptosis in neurodegeneration'. J. Neurol. Sci, 139 :45-52 [Details]
(1996) 'The repression of apoptosis by activated abl oncogenes in chronic myelogenous leukaemia'
Fernandes RS, Gorman AM, McGahon A, Lawlor M, McCann S, Cotter TG. (1996) 'The repression of apoptosis by activated abl oncogenes in chronic myelogenous leukaemia'. Leukaemia, 10 :S17-S21 [Details]
(1995) 'Modulation by ionotropic excitatory amino acids and K+ of trans-ACPD stimulated phosphoinositide hydrolysis in mouse cerebellar granule cells'
Gorman A, Grieve A, Griffiths R. (1995) 'Modulation by ionotropic excitatory amino acids and K+ of trans-ACPD stimulated phosphoinositide hydrolysis in mouse cerebellar granule cells'. J. Neurochem, 65 :2473-2483 [Details]
(1995) 'Excitatory amino acid-induced cytotoxicity in primary cultures of mouse cerebellar granule cells correlates with elevated, sustained c-fos protooncogene expression'
Gorman A, Scott MP, Rumbsby PC, Meredith C, Griffiths R. (1995) 'Excitatory amino acid-induced cytotoxicity in primary cultures of mouse cerebellar granule cells correlates with elevated, sustained c-fos protooncogene expression'. Neurosci. Lett, 191 :116-120 [Details]
(1994) 'Sulphur-containing excitatory amino acid-stimulated inositol phosphate formation in primary cultures of cerebellar granule cells is mediated predominantly by N-methyl-D-aspartate receptors'
Gorman A, Griffiths R. (1994) 'Sulphur-containing excitatory amino acid-stimulated inositol phosphate formation in primary cultures of cerebellar granule cells is mediated predominantly by N-methyl-D-aspartate receptors'. Neuroscience, 59 :299-308 [Details]
(1994) 'L-Trans-pyrrolidine-2,4-dicarboxylate and cis-1-aminocyclobutane-1,3-dicarboxylate behave as transportable, competitive inhibitors of the high-affinity glutamate transporters'
Griffiths R, Dunlop J, Gorman A, Senior J, Grieve A. (1994) 'L-Trans-pyrrolidine-2,4-dicarboxylate and cis-1-aminocyclobutane-1,3-dicarboxylate behave as transportable, competitive inhibitors of the high-affinity glutamate transporters'. Biochem. Pharmacol, 47 :267-272 [Details]
(1992) 'The effects of the peripheral-type benzodiazepine acceptor ligands, Ro-5-4864 and PK-11195, on mitochondrial respiration'
Zisterer DM, Gorman A, Williams DC, Murphy MP. (1992) 'The effects of the peripheral-type benzodiazepine acceptor ligands, Ro-5-4864 and PK-11195, on mitochondrial respiration'. Methods and Findings in Experimental and Clinical Pharmacology, 14 :85-90 [Details]
(1990) 'In vitro screening for anticonvulsant-induced teratogenesis in neural primary cultures and cell lines. Preliminary observations'
Regan CM, Gorman A, Larsson OM, Maguire C, Martin ML, Schousboe A, Williams DC. (1990) 'In vitro screening for anticonvulsant-induced teratogenesis in neural primary cultures and cell lines. Preliminary observations'. Int. J. Devl. Neuroscience, 8 :143-150 [Details]
(1989) 'Antiproliferative actions of benzodiazepines in cultured brain cells is not mediated through the peripheral-type benzodiazepine acceptor'
Gorman A, O'Beirne G, Regan C, Williams DC. (1989) 'Antiproliferative actions of benzodiazepines in cultured brain cells is not mediated through the peripheral-type benzodiazepine acceptor'. J. Neurochem, 53 :849-855 [Details]

Book Chapters

  Year Publication
(2018) 'eIF2 alpha'
Pakos-Zebrucka K, Gorman A, Chintha C, Chevet E, Samali A, Mnich K (2018) 'eIF2 alpha' In: Encyclopedia of Signaling Molecules. https://www.springer.com/gp: Springer International Publishing. [DOI] [Details]
(2015) 'Induction of autophagy: Role of endoplasmic reticulum stress and unfolded protein response'
Yeganeh B, Jäger R, Gorman AM, Samali A, Ghavami S (2015) 'Induction of autophagy: Role of endoplasmic reticulum stress and unfolded protein response' In: AUTOPHAGY. CANCER, OTHER PATHOLOGIES, INFLAMMATION, IMMUNITY AND INFECTION. :97-101 Netherlands: Elsevier Inc. [Details]
(2006) 'Heat shock proteins and the regulation of apoptosis'
Fitzgerald, U, Gorman AM, Samali A. (2006) 'Heat shock proteins and the regulation of apoptosis' In: Heat Shock Proteins in Neural Cells. :53-66 TX, USA: Landes Bioscience. [Details]
(2006) 'The role of heat shock proteins in neuronal differentiation and development'
Reed Herbert K, Samali A, Gorman AM. (2006) 'The role of heat shock proteins in neuronal differentiation and development' In: Heat Shock Proteins in Neural Cells. :25-37 TX, USA: Landes Bioscience. [Details]
(1996) 'Morphological assessment of apoptosis'
Gorman A, McCarthy J, Finucane D, Reville W, Cotter T. (1996) 'Morphological assessment of apoptosis' In: Techniques in Apoptosis: A User's Guide. :1-26 [Details]

Conference Publications

  Year Publication
(2019) CYTOKINE
Duvigneau, JC;Luis, A;Gorman, AM;Samali, A;Kaltenecker, D;Moriggl, R;Kozlov, AV (2019) Crosstalk between inflammatory mediators and endoplasmic reticulum stress in liver diseases CYTOKINE [DOI] [Details]
(2014) Irish Association for Cancer Research
Toner, AP; Giles, FJ; Carleton, LA; O’Connell, E; Harte, E; Breen, L; Dunne. G; Clynes, M; Lewis, JD; Gorman, AM; Sullivan, FJ; Glynn, SA. (2014) Characterisation of a new class of prostate cancer chemotherapeutics Irish Association for Cancer Research [Details]
(2014) 50th Annual Meeting of the American-Society-of-Clinical-Oncology
Toner, AP,Giles, FJ,Sullivan, F,Harte, E,Carleton, LA,Gorman, AM,Lewis, J,Glynn, SA (2014) Further preclinical assessment of compound EL102 in the treatment of prostate cancer . In: JOURNAL OF CLINICAL ONCOLOGY eds. 50th Annual Meeting of the American-Society-of-Clinical-Oncology [Details]
(2013) British Association of Urological Surgeons AGM
Toner, AP; McLaughlin, F; Giles, FJ; Sullivan, FJ; O’Connell, E; Carleton, LA; Breen, L; Gorman , AM; Lewis, JD and Glynn, SA. (2013) Introducing Novel Toluidine Sulphonamide EL102: A Potential Chemotherapeutic In Prostate Cancer British Association of Urological Surgeons AGM [Details]
(2011) Neuroscience Ireland 2011
Walsh S, Mnich K, Finn DP, Gorman AM, Mackie K, Dowd E. (2011) Expression of the cannabinoid CB1 receptor is decreased in the ipsilateral substantia nigra in hemi-parkinsonian rats Neuroscience Ireland 2011 , pp.S192-pp19 [Details]
(2010) Neuroscience Ireland 2010
Walsh S, Finn DP, Gorman AM and Dowd E. T (2010) The effect of pharmacological activation or blockade of the endocannabinoid system on the development of levodopa-induced dyskinesias in a rat model Neuroscience Ireland 2010 [Details]
(2009) BIOCHEMICAL SOCIETY TRANSACTIONS
Gorman, AM;Doyle, KM (2009) Considerations and recent advances in neuroscience BIOCHEMICAL SOCIETY TRANSACTIONS , pp.299-302 [DOI] [Details]
(2009) Considerations and recent advances in neuroscience
Gorman, AM,Doyle, KM (2009) BIOCHEMICAL SOCIETY TRANSACTIONS Considerations and recent advances in neuroscience , pp.299-302 [DOI] [Details]
(2009) Neuroscience Ireland 2009
Walsh S, Mnich K, Finn DP, Gorman AM, Mackie K, Dowd E (2009) Cannabinoid CB1 receptor expression is reduced following terminal lesion of the nigrostriatal pathway in the rat Neuroscience Ireland 2009 , pp.2-44 [Details]
(2008) NeuroScience Ireland
Yao L., O'Brien N., O'Connell C., Sherlock R., Damodaran A., Gorman A., Wang S., Windebank A., Pandit A. (2008) The use of Biomaterials structural and functional cues for neural regeneration NeuroScience Ireland [Details]
(1996) Oxidative stress and apoptosis in neurodegeneration
Gorman, AM,McGowan, A,ONeill, C,Cotter, T (1996) JOURNAL OF THE NEUROLOGICAL SCIENCES Oxidative stress and apoptosis in neurodegeneration , pp.45-52 [Details]
(1996) The repression of apoptosis by activated abl oncogenes in chronic myelogenous leukaemia
Fernandes, RS,Gorman, AM,McGahon, A,Lawlor, M,McCann, S,Cotter, TG (1996) LEUKEMIA The repression of apoptosis by activated abl oncogenes in chronic myelogenous leukaemia , pp.17-21 [Details]

Other Journals

  Year Publication
(2011) 'The effect of pharmacological activation or blockade of the endocannabinoid system on the development of levodopa-induced dyskinesias in a rat model'
Walsh S, Finn DP, Gorman AM and Dowd E. (2011) 'The effect of pharmacological activation or blockade of the endocannabinoid system on the development of levodopa-induced dyskinesias in a rat model' Irish Journal of Medical Science, 180 :20-20. [Details]
(2011) 'Heat shock protein gene therapy in the alpha-synuclein viral gene transfer rat model of Parkinson’s disease'
Hyland, R., A.M. Gorman, A. O'Doherty, and Dowd, E (2011) 'Heat shock protein gene therapy in the alpha-synuclein viral gene transfer rat model of Parkinson’s disease' Irish Journal of Medical Science, 180 :18-19. [Details]
(2009) 'Considerations and recent advances in neuroscience. Meeting report of 2nd Neuroscience Ireland Conference'
Doyle KM, Gorman AM (2009) 'Considerations and recent advances in neuroscience. Meeting report of 2nd Neuroscience Ireland Conference' Biochem Soc Trans, 37 :299-302. [Details]
(2008) 'Considerations and recent advances in neuroscience'
Doyle KM, Gorman AM (2008) 'Considerations and recent advances in neuroscience' Biochem Soc Trans, 37 :299-302. [Details]
(2006) 'Helping keep our neurons alive with neurotrophins'
Gorman AM (2006) 'Helping keep our neurons alive with neurotrophins' The Irish Scientist Yearbook, 14 . [Details]
(1999) 'Challenging the dogmas'
Gorman AM, Zhivotovsky B. (1999) 'Challenging the dogmas' Cell Death Diff, 6 :207-211. [Details]

Conference Contributions

  Year Publication
(2011) Irish Journal of Medical Science,
Walsh S, Finn DP, Gorman AM and Dowd E. (2011) The effect of pharmacological activation or blockade of the endocannabinoid system on the development of levodopa-induced dyskinesias in a rat model. Irish Journal of Medical Science, . [Details]
(2011) Irish Journal of Medical Science,
Hyland, R., A.M. Gorman, A. O'Doherty, and Dowd, E. (2011) HEAT SHOCK PROTEIN GENE THERAPY IN THE ALPHA-SYNUCLEIN VIRAL GENE TRANSFER RAT MODEL OF PARKINSON'S DISEASE. Irish Journal of Medical Science, . [Details]
(2010) Apoptosis Symposium,
Gorman A, Szegezdi E, Samali A. (2010) A one day international meeting of researchers in Galway, 2010. [Conference Organising Committee Member], Apoptosis Symposium, Galway , 20-AUG-10 - 20-AUG-10. [Details]

Abstract

  Year Publication
(2011) Expression of genes related to neurotrophin signalling in breast cancer - in search of novel therapeutic techniques.
Helen, E,Healy, N,Gorman, A,Miller, N,Kerin, MJ (2011) Expression of genes related to neurotrophin signalling in breast cancer - in search of novel therapeutic techniques. Abstract [Details]
(2011) NERVE GROWTH FACTOR MEDIATES ACTIVE CASPASE-3 TURNOVER IN APOPTOTIC PC12 CELLS.
Carleton, LA,Mnich, K,Kavanagh, ET,Doyle, K,Samali, A,Gorman, AM (2011) NERVE GROWTH FACTOR MEDIATES ACTIVE CASPASE-3 TURNOVER IN APOPTOTIC PC12 CELLS. Abstract [Details]
(2011) HEAT SHOCK PROTEIN GENE THERAPY IN THE ALPHA-SYNUCLEIN VIRAL GENE TRANSFER RAT MODEL OF PARKINSON'S DISEASE.
Hyland, R,Gorman, AM,O'Doherty, A,Dowd, E (2011) HEAT SHOCK PROTEIN GENE THERAPY IN THE ALPHA-SYNUCLEIN VIRAL GENE TRANSFER RAT MODEL OF PARKINSON'S DISEASE. Abstract [Details]
(2011) THE EFFECT OF PHARMACOLOGICAL ACTIVATION OR BLOCKADE OF THE ENDOCANNABINOID SYSTEM ON THE DEVELOPMENT OF LEVODOPA-INDUCED DYSKINESIAS IN A RAT MODEL.
Walsh, S,Finn, DP,Gorman, AM,Dowd, E (2011) THE EFFECT OF PHARMACOLOGICAL ACTIVATION OR BLOCKADE OF THE ENDOCANNABINOID SYSTEM ON THE DEVELOPMENT OF LEVODOPA-INDUCED DYSKINESIAS IN A RAT MODEL. Abstract [Details]
(2007) Laminin peptide gradient in a collagen scaffold shows guidance effect on neurite growth. Tissue Eng.
Yao L, Damodaran G, Natalia N, Gorman A, Windebank A, Pandit A. (2007) Laminin peptide gradient in a collagen scaffold shows guidance effect on neurite growth. Tissue Eng. Abstract [Details]
(2007) Laminin peptide gradient in a collagen scaffold shows guidance effect on neurite growth.
Yao, L,Damodaran, G,Natalia, N,Gorman, A,Windebank, A,Pandit, A (2007) Laminin peptide gradient in a collagen scaffold shows guidance effect on neurite growth. Abstract [Details]
(2006) Guided Neurite Growth on a Graded Laminin Conjugated Enzymatically Cross-Linked Collagen Scaffold. Gordon Research Conference on Signal Transduction by Engineered Extracellular Matrices.
Yao L, Damodaran G, Nikolskaya N, Gorman A, Windebank AJ, Pandit A. (2006) Guided Neurite Growth on a Graded Laminin Conjugated Enzymatically Cross-Linked Collagen Scaffold. Gordon Research Conference on Signal Transduction by Engineered Extracellular Matrices. Connecticut College, New London, CT: Abstract [Details]

Conference Paper

  Year Publication
(2007) Laminin Peptide Gradient in a Collagen Scaffold Shows Guidance Effect on Neurite Growth. Tissue Engineering and Regenerative Medicine International Society Meeting.
Yao, L., Damodaran, G., Natalia, N., Gorman, A., Windebank, A., and Pandit, A. (2007) Laminin Peptide Gradient in a Collagen Scaffold Shows Guidance Effect on Neurite Growth. Tissue Engineering and Regenerative Medicine International Society Meeting. London, U.K: Conference Paper [Details]

Conference Poster

  Year Publication
(2008) The Use of Biomaterials Structural and Functional Cues for Neural Regeneration. Neuroscience Ireland.
Yao, L., O'Brien, N., O'Connell, C., Sherlock, R., Damodaran, G., Gorman, A., Wang, S., Windebank, W. and Pandit, A. (2008) The Use of Biomaterials Structural and Functional Cues for Neural Regeneration. Neuroscience Ireland. Galway, Ireland: Conference Poster [Details]
(2008) Functionalised Biodegradable Polymer Scaffold for Nerve Regeneration. 5th Tissue Engineering Symposium.
O' Connell, C., Yao, L., Sherlock, R., Cui, C., Damodaron, G., Gorman, A., Windebank, A., Wang, S.G. and Pandit, A. (2008) Functionalised Biodegradable Polymer Scaffold for Nerve Regeneration. 5th Tissue Engineering Symposium. Tampere, Finland: Conference Poster [Details]
(2007) Functionalised Microchannels Guide Neurite Growth on a PLGA Scaffold. 21st European Conference on Biomaterials.
Yao, L., Cui, WJ., Sherlock, R., O'Connell, C., Damodaran, G., Gorman, A., Windebank, A., Wang, S.G., and Pandit, A. (2007) Functionalised Microchannels Guide Neurite Growth on a PLGA Scaffold. 21st European Conference on Biomaterials. Brighton, U.K: Conference Poster [Details]
(2006) Guided Neurite Growth on a Graded Laminin Conjugated Enzymatically Cross-Linked Collagen Scaffold. Gordon Research Conference on Signal Transduction through Engineered Matrices.
Yao, L., Damodaran, G., Nikolskaya, N., Gorman, A., Windebank, A., and Pandit, A. (2006) Guided Neurite Growth on a Graded Laminin Conjugated Enzymatically Cross-Linked Collagen Scaffold. Gordon Research Conference on Signal Transduction through Engineered Matrices. New London, Connecticut: Conference Poster [Details]
(2006) Guided Neurite Growth on a Graded Laminin Conjugated Enzymatically Cross-Linked Collagen Scaffold. Tissue Engineering and Regenerative Medicine International Society Meeting.
Yao, L., Damodaran, G., Nikolskaya, N., Gorman, A., Windebank, A.J., and Pandit, A. (2006) Guided Neurite Growth on a Graded Laminin Conjugated Enzymatically Cross-Linked Collagen Scaffold. Tissue Engineering and Regenerative Medicine International Society Meeting. Rotterdam: Conference Poster [Details]

Editorial

  Year Publication
(2010) Cell Stress and Cell Death. International Journal of Cell Biology.
Afshin Samali, Simone Fulda, Adrienne M. Gorman, Osamu Hori, and Srinivasa M. Srinivasula (2010) Cell Stress and Cell Death. International Journal of Cell Biology. Editorial [DOI] [Details]

Meeting

  Year Publication
(2013) HSP70 reduces alpha-synuclein-induced neuronal pathology in the alpha-synuclein viral gene transfer rat model of Parkinson's disease.
Moloney, T,Hyland, R,O'Toole, D,Paucard, A,Kirik, D,Doherty, AO,Gorman, A,Dowd, E (2013) HSP70 reduces alpha-synuclein-induced neuronal pathology in the alpha-synuclein viral gene transfer rat model of Parkinson's disease. Meeting [Details]
(2010) CANNABINOID CB1 RECEPTOR EXPRESSION IS REDUCED FOLLOWING TERMINAL LESION OF THE NIGROSTRIATAL PATHWAY IN THE RAT.
Walsh, S,Mnich, K,Finn, DP,Gorman, AM,Mackie, K,Dowd, E (2010) CANNABINOID CB1 RECEPTOR EXPRESSION IS REDUCED FOLLOWING TERMINAL LESION OF THE NIGROSTRIATAL PATHWAY IN THE RAT. Meeting [Details]
(2009) Analysis of cellular environment of spinal cord lesion following transplantation of neural stem cells into injured rat spinal cord.
Hynes, J,Bourke, E,Deering, EM,Doherty, G,Murray, A,Dockery, P,Doyle, K,Gorman, A,Barry, FP,McMahon, SS (2009) Analysis of cellular environment of spinal cord lesion following transplantation of neural stem cells into injured rat spinal cord. Meeting [Details]
(2001) Involvement of caspase-3 in photoreceptor apoptosis induced by blue light exposure.
Chen, E,Wu, J,Gorman, A,Zhou, X,Sandra, C (2001) Involvement of caspase-3 in photoreceptor apoptosis induced by blue light exposure. Meeting [Details]

Reviews

  Year Publication
(2020) Tumour Cell Secretome in Chemoresistance and Tumour Recurrence.
Madden, EC;Gorman, AM;Logue, SE;Samali, A (2020) Tumour Cell Secretome in Chemoresistance and Tumour Recurrence. CAMBRIDGE: CELL PRESS Reviews [DOI] [Details]
(2019) Endoplasmic reticulum stress signalling - from basic mechanisms to clinical applications.
Almanza, A;Carlesso, A;Chintha, C;Creedican, S;Doultsinos, D;Leuzzi, B;Luis, A;McCarthy, N;Montibeller, L;More, S;Papaioannou, A;Puschel, F;Sassano, ML;Skoko, J;Agostinis, P;de Belleroche, J;Eriksson, LA;Fulda, S;Gorman, AM;Healy, S;Kozlov, A;Munoz-Pinedo, C;Rehm, M;Chevet, E;Samali, A (2019) Endoplasmic reticulum stress signalling - from basic mechanisms to clinical applications. HOBOKEN: WILEY Reviews [DOI] [Details]
(2018) Glioblastoma and chemoresistance to alkylating agents: Involvement of apoptosis, autophagy, and unfolded protein response.
Hombach-Klonisch, S;Mehrpour, M;Shojaei, S;Harlos, C;Pitz, M;Hamai, A;Siemianowicz, K;Likus, W;Wiechec, E;Toyota, BD;Hoshyar, R;Seyfoori, A;Sepehri, Z;Ande, SR;Khadem, F;Akbari, M;Gorman, AM;Samali, A;Klonisch, T;Ghavami, S (2018) Glioblastoma and chemoresistance to alkylating agents: Involvement of apoptosis, autophagy, and unfolded protein response. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD Reviews [DOI] [Details]
(2016) Neurotrophins and B-cell malignancies.
Hillis, J;O'Dwyer, M;Gorman, AM (2016) Neurotrophins and B-cell malignancies. BASEL: SPRINGER BASEL AG Reviews [DOI] [Details]
(2013) Stress-induced self-cannibalism: on the regulation of autophagy by endoplasmic reticulum stress.
Deegan, S;Saveljeva, S;Gorman, AM;Samali, A (2013) Stress-induced self-cannibalism: on the regulation of autophagy by endoplasmic reticulum stress. BASEL: SPRINGER BASEL AG Reviews [DOI] [Details]
(2013) The eIF2 alpha kinases: their structures and functions.
Donnelly, N;Gorman, AM;Gupta, S;Samali, A (2013) The eIF2 alpha kinases: their structures and functions. BASEL: SPRINGER BASEL AG Reviews [DOI] [Details]
(2012) Stress management at the ER: Regulators of ER stress-induced apoptosis.
Gorman, AM,Healy, SJM,Jager, R,Samali, A (2012) Stress management at the ER: Regulators of ER stress-induced apoptosis. Reviews [DOI] [Details]
(2012) The unfolded protein response at the crossroads of cellular life and death during endoplasmic reticulum stress.
Jager, R;Bertrand, MJM;Gorman, AM;Vandenabeele, P;Samali, A (2012) The unfolded protein response at the crossroads of cellular life and death during endoplasmic reticulum stress. HOBOKEN: WILEY-BLACKWELL Reviews [DOI] [Details]
(2012) Stress management at the ER: Regulators of ER stress-induced apoptosis.
Gorman, AM;Healy, SJM;Jager, R;Samali, A (2012) Stress management at the ER: Regulators of ER stress-induced apoptosis. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD Reviews [DOI] [Details]
(2011) Unfolded proteins and Endoplasmic Reticulum stress in neurodegenerative disorders.
Doyle KM, Kennedy D, Gorman AM, Gupta S, Healy SJ, Samali A. (2011) Unfolded proteins and Endoplasmic Reticulum stress in neurodegenerative disorders. Reviews [Details]
(2011) Unfolded proteins and endoplasmic reticulum stress in neurodegenerative disorders.
Doyle, KM,Kennedy, D,Gorman, AM,Gupta, S,Healy, SJM,Samali, A (2011) Unfolded proteins and endoplasmic reticulum stress in neurodegenerative disorders. Reviews [DOI] [Details]
(2009) Targeting the endoplasmic reticulum-stress response as an anticancer strategy.
Healy, SJM;Gorman, AM;Mousavi-Shafaei, P;Gupta, S;Samali, A (2009) Targeting the endoplasmic reticulum-stress response as an anticancer strategy. AMSTERDAM: ELSEVIER SCIENCE BV Reviews [DOI] [Details]
(2009) Involvement of Akt in neurite outgrowth.
Read, DE;Gorman, AM (2009) Involvement of Akt in neurite outgrowth. BASEL: SPRINGER BASEL AG Reviews [DOI] [Details]
(2009) Heat shock protein 27 in neuronal survival and neurite outgrowth.
Read, DE;Gorman, AM (2009) Heat shock protein 27 in neuronal survival and neurite outgrowth. SAN DIEGO: ACADEMIC PRESS INC ELSEVIER SCIENCE Reviews [DOI] [Details]
(2009) Targeting the endoplasmic reticulum-stress response as an anticancer strategy.
Healy, SZ, Gorman, AM, Mousavi-Shafaei, P, Gupta, S, Samali, A. (2009) Targeting the endoplasmic reticulum-stress response as an anticancer strategy. Reviews [Details]
(2009) Involvement of Akt in neurite outgrowth.
Read, DE,Gorman, AM (2009) Involvement of Akt in neurite outgrowth. Reviews [DOI] [Details]
(2009) Heat shock protein 27 in neuronal survival and neurite outgrowth.
Read, DE,Gorman, AM (2009) Heat shock protein 27 in neuronal survival and neurite outgrowth. Reviews [DOI] [Details]
(2008) Neuronal cell death in neurodegenerative diseases: recurring themes around protein handling.
Gorman, AM (2008) Neuronal cell death in neurodegenerative diseases: recurring themes around protein handling. Reviews [DOI] [Details]
(2008) Neuronal cell death in neurodegenerative diseases: recurring themes around protein handling.
Gorman, AM (2008) Neuronal cell death in neurodegenerative diseases: recurring themes around protein handling. HOBOKEN: WILEY Reviews [DOI] [Details]
(2006) Mediators of endoplasmic reticulum stress-induced apoptosis.
Szegezdi, E;Logue, SE;Gorman, AM;Samali, A (2006) Mediators of endoplasmic reticulum stress-induced apoptosis. LONDON: NATURE PUBLISHING GROUP Reviews [DOI] [Details]
(2006) Mediators of endoplasmic reticulum stress-induced apoptosis.
Szegezdi, E,Logue, SE,Gorman, AM,Samali, A (2006) Mediators of endoplasmic reticulum stress-induced apoptosis. Reviews [DOI] [Details]
(2006) Mediators of endoplasmic reticulum stress-induced apoptosis. EMBO Rep.
Szegezdi E., Logue S.E., Gorman A.M., Samali A. (2006) Mediators of endoplasmic reticulum stress-induced apoptosis. EMBO Rep. Reviews [Details]
(2003) On the role of Hsp27 in regulating apoptosis. Apoptosis.
Concannon C.G., Gorman A.M., Samali A. (2003) On the role of Hsp27 in regulating apoptosis. Apoptosis. Reviews [Details]
(2003) On the role of Hsp27 in regulating apoptosis.
Concannon, CG;Gorman, AM;Samalli, A (2003) On the role of Hsp27 in regulating apoptosis. DORDRECHT: KLUWER ACADEMIC PUBL Reviews [Details]
(2003) On the role of Hsp27 in regulating apoptosis.
Concannon, CG,Gorman, AM,Samalli, A (2003) On the role of Hsp27 in regulating apoptosis. Reviews [Details]
(2002) Cellular longevity: role of apoptosis and replicative senescenece. Biogerontology.
Bree RT, Stenson C, Grealy M, Byrnes L, Gorman AM and Samali A (2002) Cellular longevity: role of apoptosis and replicative senescenece. Biogerontology. Reviews [Details]
(2002) Cellular longevity: role of apoptosis and replicative senescence.
Bree, RT,Stenson-Cox, C,Grealy, M,Byrnes, L,Gorman, AM,Samali, A (2002) Cellular longevity: role of apoptosis and replicative senescence. Reviews [Details]
(2002) Cellular longevity: role of apoptosis and replicative senescence.
Bree, RT;Stenson-Cox, C;Grealy, M;Byrnes, L;Gorman, AM;Samali, A (2002) Cellular longevity: role of apoptosis and replicative senescence. NEW YORK: SPRINGER Reviews [Details]
(1996) Apoptosis - The story so far .
Samali, A,Gorman, AM,Cotter, TG (1996) Apoptosis - The story so far . Reviews [Details]