Medicine

Dr Andrea Kwakowsky

PhD

Contact Details

Lecturer Above the Bar/ Programme Director MSc in Neuropharmacology
University Road, H91W5P7
Human Biology Building
3rd floor
Pharmacology & Therapeutics
T: 091493012
E: andrea.kwakowsky@universityofgalway.ie
@kwakowsky

Biography

Dr Andrea Kwakowsky's primary research interest is in the molecular and cellular basis of brain function in Alzheimer's disease (AD), Huntington's disease (HD) and Multiple sclerosis (MS). This research involves multi-disciplinary studies using invaluable human tissue, animal models, and advanced scientific technologies including, the newest molecular and imaging techniques. Dr Kwakowsky is a graduate of Eötvös Loránd University, Budapest, Hungary (MSc and PhD). She has held academic positions at the Institute of Experimental Medicine, Hungary (Junior Research Fellow), the University of Otago, New Zealand (Postdoctoral Fellow/Research Fellow), and the University of Auckland, New Zealand (Senior Research Fellow) before taking up a lectureship at the National University of Ireland Galway. She was awarded the prestigious Aotearoa Foundation Fellowship, the Alzheimer's New Zealand, and the Freemasons New Zealand Senior Research Fellowships. Dr Kwakowsky's ultimate goal is to find novel drug targets and therapeutic strategies for AD.

Research Interests

In the Kwakowsky laboratory, we conduct multi-disciplinary research that aims to transform the understanding of the pathological mechanisms of neurodegenerative diseases and find novel drug targets and therapeutic strategies. I have a long-standing interest in understanding the pathology of neurodegenerative diseases, such as Alzheimer¿s, Huntington¿s disease and Multiple Sclerosis, and finding novel drug targets and therapeutic strategies. I am leading an integrated multidisciplinary research that involves studies using invaluable human tissue, animal and in vitro models, and advanced scientific technologies including, the newest molecular and imaging techniques and aims to understand the underlying pathology of these disorders and to determine whether manipulation of specific neuronal pathways could be part of an effective treatment. This research established the scientific basis for cell-type-specific modulation of neuronal networks and neuroinflammatory pathways as potential therapeutic interventions.

Our recent findings on the excitatory/inhibitory remodelling in the Alzheimer`s brain have opened new avenues in the development of disease-modifying therapies and drug approaches for the disease. Currently, my team¿s major research focus is on drug testing and the development of a brain stimulation therapy for AD. Through some projects, we aim to understand better the mechanism of action of the most promising identified drug candidates using electrophysiology, fiber photometry, behavioural testing, immunohistochemistry and RNA sequencing. We have also developed a novel cell type-specific brain stimulation approach as a potential treatment to modulate the excitatory/inhibitory balance to restore neuronal activity and cognitive function in a mouse Alzheimer`s disease model. The focus of the current work is on the examination of the underlying mechanisms of the beneficial behavioural outcomes of the stimulation and refining the protocol to achieve the maximum possible therapeutic benefit and translation of the findings to the clinic. We are also exploring the potential of dietary interventions for dementia prevention and restoring cognitive performance.

Research Interests: Neuroscience, Alzheimer's and Huntington's disease, Multiple Sclerosis, Human neurodegenerative diseases, Gamma-aminobutyric acid (GABA) and glutamate signalling, Estrogen signalling, Neurotrophin signalling, Neuroprotection, Neuroinflammation

Peer Reviewed Journals

	Year	Publication
	(2023)	'Editorial: Neuroinflammation and neurodegeneration from bench to bedside' Wael M. Y. Mohamed and Andrea Kwakowsky (2023) 'Editorial: Neuroinflammation and neurodegeneration from bench to bedside'. Frontiers In Neurology, 14 (1296760) [DOI] [Details]
	(2023)	'Microglial and Astrocytic Responses in the Human Midcingulate Cortex in Huntington's Disease' Palpagama T, Mills AR, Ferguson MW, Vikas Ankeal P, Turner C, Tippett L, van der Werf B, Waldvogel HJ, Faull RLM, Kwakowsky A. (2023) 'Microglial and Astrocytic Responses in the Human Midcingulate Cortex in Huntington's Disease'. Ann Neurol, [DOI] [Details]
	(2023)	'Metabotropic glutamate receptor 1 alpha: a unique receptor variant with variable implications for Alzheimer's disease pathogenesis' Yeung, J. H.,Kwakowsky, A. (2023) 'Metabotropic glutamate receptor 1 alpha: a unique receptor variant with variable implications for Alzheimer's disease pathogenesis'. Neural Regen Res, 18 (1010):2196-2197 [Details]
	(2023)	'Retinal inner nuclear layer thickness in the diagnosis of cognitive impairment explored using a C57BL/6J mouse model' Maran, J. J.,Adesina, M. M.,Green, C. R.,Kwakowsky, A.,Mugisho, O. O. (2023) 'Retinal inner nuclear layer thickness in the diagnosis of cognitive impairment explored using a C57BL/6J mouse model'. Sci Rep, 13 (11) [Details]
	(2023)	'Is Hormone Replacement Therapy a Risk Factor or a Therapeutic Option for Alzheimer's Disease?' Mills, Z. B.,Faull, R. L. M.,Kwakowsky, A. (2023) 'Is Hormone Replacement Therapy a Risk Factor or a Therapeutic Option for Alzheimer's Disease?'. Int J Mol Sci, 24 (44) [Details]
	(2023)	'Editorial: Estrogen effects on fertility and neurodegeneration - classical versus non-classical actions' Nagy, Z.,Herbison, A.,Kwakowsky, A.,Kovacs, G.,Barabas, K. (2023) 'Editorial: Estrogen effects on fertility and neurodegeneration - classical versus non-classical actions'. Front Endocrinol (Lausanne), 14 [Details]
	(2023)	'Is caffeine a potential therapeutic intervention for Alzheimer¿s disease?' Zhai, Y., Yelanchezian,M.M., Kwakowsky a. (2023) 'Is caffeine a potential therapeutic intervention for Alzheimer¿s disease?'. Neuromodulation, 2 (2):36-46 [DOI] [Details]
	(2023)	'Editorial: Neuronal network dysfunction in neurodegenerative disorders' Kwakowsky, A.,Prasad, A. A.,Pena-Ortega, F.,Lim, S. A. O. (2023) 'Editorial: Neuronal network dysfunction in neurodegenerative disorders'. Front Neurosci, 17 [Details]
	(2023)	'Cation-Chloride Cotransporters KCC2 and NKCC1 as Therapeutic Targets in Neurological and Neuropsychiatric Disorders' Lam, P.,Newland, J.,Faull, R. L. M.,Kwakowsky, A. (2023) 'Cation-Chloride Cotransporters KCC2 and NKCC1 as Therapeutic Targets in Neurological and Neuropsychiatric Disorders'. Molecules, 28 (33) [Details]
	(2023)	'Is EAAT2 a potential therapeutic intervention target for Alzheimer's disease?' Wood, O. W.,Yeung, J. H.,Kwakowsky, A. (2023) 'Is EAAT2 a potential therapeutic intervention target for Alzheimer's disease?'. Neural Regen Res, 18 (88):1721-1722 [Details]
	(2023)	'The central role of the NLRP3 inflammasome pathway in the pathogenesis of age-related diseases in the eye and the brain' Maran, J. J.,Adesina, M. M.,Green, C. R.,Kwakowsky, A.,Mugisho, O. O. (2023) 'The central role of the NLRP3 inflammasome pathway in the pathogenesis of age-related diseases in the eye and the brain'. Ageing Res Rev, 88 [Details]
	(2022)	'iGluR expression in the hippocampal formation, entorhinal cortex, and superior temporal gyrus in Alzheimer's disease' Y. Yeung JH,Waldvogel, H. J.,M. Faull RL,Kwakowsky, A. (2022) 'iGluR expression in the hippocampal formation, entorhinal cortex, and superior temporal gyrus in Alzheimer's disease'. Neural Regen Res, 17 (1010):2197-2199 [Details]
	(2022)	'EAAT2 as a therapeutic research target in Alzheimer's disease: A systematic review' Wood, O. W. G.,Yeung, J. H. Y.,Faull, R. L. M.,Kwakowsky, A. (2022) 'EAAT2 as a therapeutic research target in Alzheimer's disease: A systematic review'. Front Neurosci, 16 [Details]
	(2022)	'Current and future possible therapeutic options for Huntington`s disease' M. W. Ferguson, C. J. Kennedy, T. H. Palpagama, H. J. Waldvogel, R. L. M. Faull and A. Kwakowsky (2022) 'Current and future possible therapeutic options for Huntington`s disease'. Neurobiology Of Disease, 14 [DOI] [Details]
	(2022)	'Neuroprotective Effect of Caffeine in Alzheimer's Disease' M. Yelanchezian YM,Waldvogel, H. J.,Faull, R. L. M.,Kwakowsky, A. (2022) 'Neuroprotective Effect of Caffeine in Alzheimer's Disease'. Molecules, 27 (1212) [Details]
	(2022)	'Beta-Amyloid (Abeta(1-42)) Increases the Expression of NKCC1 in the Mouse Hippocampus' Lam, P.,Vinnakota, C.,Guzman, B. C.,Newland, J.,Peppercorn, K.,Tate, W. P.,Waldvogel, H. J.,Faull, R. L. M.,Kwakowsky, A. (2022) 'Beta-Amyloid (Abeta(1-42)) Increases the Expression of NKCC1 in the Mouse Hippocampus'. Molecules, 27 (88) [Details]
	(2022)	'mGluR1alpha expression in the hippocampus, subiculum, entorhinal cortex and superior temporal gyrus in Alzheimer's disease' Yeung, J. H. Y.,Palpagama, T. H.,Turner, C.,Waldvogel, H. J.,Faull, R. L. M.,Kwakowsky, A. (2022) 'mGluR1alpha expression in the hippocampus, subiculum, entorhinal cortex and superior temporal gyrus in Alzheimer's disease'. IBRO Neurosci Rep, 13 :78-86 [Details]
	(2021)	'The effect of age and sex on the expression of GABA signaling components in the human hippocampus and entorhinal cortex' Ethiraj, J.,Palpagama, T. H.,Turner, C.,van der Werf, B.,Waldvogel, H. J.,Faull, R. L. M.,Kwakowsky, A. (2021) 'The effect of age and sex on the expression of GABA signaling components in the human hippocampus and entorhinal cortex'. Sci Rep, 11 (11) [Details]
	(2021)	'The effects of amyloid-beta on hippocampal glutamatergic receptor and transporter expression' Kwakowsky, A.,Waldvogel, H. J.,Faull, R. L. (2021) 'The effects of amyloid-beta on hippocampal glutamatergic receptor and transporter expression'. Neural Regen Res, 16 (77):1399-1401 [Details]
	(2021)	'Glutamatergic receptor expression changes in the Alzheimer's disease hippocampus and entorhinal cortex' Yeung, J. H. Y.,Walby, J. L.,Palpagama, T. H.,Turner, C.,Waldvogel, H. J.,Faull, R. L. M.,Kwakowsky, A. (2021) 'Glutamatergic receptor expression changes in the Alzheimer's disease hippocampus and entorhinal cortex'. Brain Pathol, 31 (66) [Details]
	(2021)	'The Effects of General Anaesthesia and Light on Behavioural Rhythms and GABA(A) Receptor Subunit Expression in the Mouse SCN' Chong, J.,Cheeseman, J. F.,Pawley, M. D. M.,Kwakowsky, A.,Warman, G. R. (2021) 'The Effects of General Anaesthesia and Light on Behavioural Rhythms and GABA(A) Receptor Subunit Expression in the Mouse SCN'. Clocks Sleep, 3 (33):482-494 [Details]
	(2021)	'Therapeutic potential of alpha 5 subunit containing GABA(A) receptors in Alzheimer's disease' Kwakowsky, A.,Waldvogel, H. J.,Faull, R. L. M. (2021) 'Therapeutic potential of alpha 5 subunit containing GABA(A) receptors in Alzheimer's disease'. Neural Regen Res, 16 (88):1550-1551 [Details]
	(2021)	'EAAT2 Expression in the Hippocampus, Subiculum, Entorhinal Cortex and Superior Temporal Gyrus in Alzheimer's Disease' Yeung, J. H. Y.,Palpagama, T. H.,Wood, O. W. G.,Turner, C.,Waldvogel, H. J.,Faull, R. L. M.,Kwakowsky, A. (2021) 'EAAT2 Expression in the Hippocampus, Subiculum, Entorhinal Cortex and Superior Temporal Gyrus in Alzheimer's Disease'. Front Cell Neurosci, 15 [Details]
	(2020)	'An 5 GABAA Receptor Inverse Agonist, 5IA, Attenuates Amyloid Beta-Induced Neuronal Death in Mouse Hippocampal Cultures' Vinnakota, C.,Govindpani, K.,Tate, W. P.,Peppercorn, K.,Anekal, P. V.,Waldvogel, H. J.,Faull, R. L. M.,Kwakowsky, A. (2020) 'An 5 GABAA Receptor Inverse Agonist, 5IA, Attenuates Amyloid Beta-Induced Neuronal Death in Mouse Hippocampal Cultures'. Int J Mol Sci, 21 (99) [Details]
	(2020)	'Amyloid-beta(1-42) induced glutamatergic receptor and transporter expression changes in the mouse hippocampus' Yeung, J. H. Y.,Calvo-Flores Guzman, B.,Palpagama, T. H.,Ethiraj, J.,Zhai, Y.,Tate, W. P.,Peppercorn, K.,Waldvogel, H. J.,Faull, R. L. M.,Kwakowsky, A. (2020) 'Amyloid-beta(1-42) induced glutamatergic receptor and transporter expression changes in the mouse hippocampus'. J Neurochem, 155 (11):62-80 [Details]
	(2020)	'Amyloid-Beta(1-42) -Induced Increase in GABAergic Tonic Conductance in Mouse Hippocampal CA1 Pyramidal Cells' Calvo-Flores Guzman, B.,Kim, S.,Chawdhary, B.,Peppercorn, K.,Tate, W. P.,Waldvogel, H. J.,Faull, R. L.,Montgomery, J.,Kwakowsky, A. (2020) 'Amyloid-Beta(1-42) -Induced Increase in GABAergic Tonic Conductance in Mouse Hippocampal CA1 Pyramidal Cells'. Molecules, 25 (33) [Details]
	(2020)	'Vascular dysfunction in Alzheimer's disease: a biomarker of disease progression and a potential therapeutic target' Govindpani, K.,Vinnakota, C.,Waldvogel, H. J.,Faull, R. L.,Kwakowsky, A. (2020) 'Vascular dysfunction in Alzheimer's disease: a biomarker of disease progression and a potential therapeutic target'. Neural Regen Res, 15 (66):1030-1032 [Details]
	(2020)	'Impaired Expression of GABA Signaling Components in the Alzheimer's Disease Middle Temporal Gyrus' Govindpani, K.,Turner, C.,Waldvogel, H. J.,Faull, R. L. M.,Kwakowsky, A. (2020) 'Impaired Expression of GABA Signaling Components in the Alzheimer's Disease Middle Temporal Gyrus'. Int J Mol Sci, 21 (2222) [Details]
	(2020)	'The Interplay Between Beta-Amyloid 1-42 (Abeta(1-42))-Induced Hippocampal Inflammatory Response, p-tau, Vascular Pathology, and Their Synergistic Contributions to Neuronal Death and Behavioral Deficits' Calvo-Flores Guzman, B.,Elizabeth Chaffey, T.,Hansika Palpagama, T.,Waters, S.,Boix, J.,Tate, W. P.,Peppercorn, K.,Dragunow, M.,Waldvogel, H. J.,Faull, R. L. M.,Kwakowsky, A. (2020) 'The Interplay Between Beta-Amyloid 1-42 (Abeta(1-42))-Induced Hippocampal Inflammatory Response, p-tau, Vascular Pathology, and Their Synergistic Contributions to Neuronal Death and Behavioral Deficits'. Front Mol Neurosci, 13 [Details]
	(2019)	'The Acute Effects of Amyloid-Beta(1-42) on Glutamatergic Receptor and Transporter Expression in the Mouse Hippocampus' Yeung, J. H. Y.,Palpagama, T. H.,Tate, W. P.,Peppercorn, K.,Waldvogel, H. J.,Faull, R. L. M.,Kwakowsky, A. (2019) 'The Acute Effects of Amyloid-Beta(1-42) on Glutamatergic Receptor and Transporter Expression in the Mouse Hippocampus'. Front Neurosci, 13 [Details]
	(2019)	'Vascular Dysfunction in Alzheimer's Disease: A Prelude to the Pathological Process or a Consequence of It?' Govindpani, K.,McNamara, L. G.,Smith, N. R.,Vinnakota, C.,Waldvogel, H. J.,Faull, R. L.,Kwakowsky, A. (2019) 'Vascular Dysfunction in Alzheimer's Disease: A Prelude to the Pathological Process or a Consequence of It?'. Journal Of Clinical Medicine, 8 (55) [Details]
	(2019)	'GABA(A) Receptors Are Well Preserved in the Hippocampus of Aged Mice' Palpagama, T. H.,Sagniez, M.,Kim, S.,Waldvogel, H. J.,Faull, R. L.,Kwakowsky, A. (2019) 'GABA(A) Receptors Are Well Preserved in the Hippocampus of Aged Mice'. Eneuroeneuro, 6 (44) [Details]
	(2019)	'The Role of Microglia and Astrocytes in Huntington's Disease' Palpagama, T. H.,Waldvogel, H. J.,Faull, R. L. M.,Kwakowsky, A. (2019) 'The Role of Microglia and Astrocytes in Huntington's Disease'. Front Mol Neurosci, 12 [Details]
	(2019)	'Sex- and age-related changes in GABA signaling components in the human cortex' Pandya, M.,Palpagama, T. H.,Turner, C.,Waldvogel, H. J.,Faull, R. L.,Kwakowsky, A. (2019) 'Sex- and age-related changes in GABA signaling components in the human cortex'. Biol Sex Differ, 10 (11) [Details]
	(2018)	'Gamma-aminobutyric acid A receptors in Alzheimer's disease: highly localized remodeling of a complex and diverse signaling pathway' Kwakowsky, A.,Calvo-Flores Guzman, B.,Govindpani, K.,Waldvogel, H. J.,Faull, R. L. (2018) 'Gamma-aminobutyric acid A receptors in Alzheimer's disease: highly localized remodeling of a complex and diverse signaling pathway'. Neural Regen Res, 13 (88):1362-1363 [Details]
	(2018)	'GABA(A) receptor subunit expression changes in the human Alzheimer's disease hippocampus, subiculum, entorhinal cortex and superior temporal gyrus' Kwakowsky, A.,Calvo-Flores Guzman, B.,Pandya, M.,Turner, C.,Waldvogel, H. J.,Faull, R. L. (2018) 'GABA(A) receptor subunit expression changes in the human Alzheimer's disease hippocampus, subiculum, entorhinal cortex and superior temporal gyrus'. J Neurochem, 145 (55):374-392 [Details]
	(2018)	'The GABAergic system as a therapeutic target for Alzheimer's disease' Calvo-Flores Guzman, B.,Vinnakota, C.,Govindpani, K.,Waldvogel, H. J.,Faull, R. L. M.,Kwakowsky, A. (2018) 'The GABAergic system as a therapeutic target for Alzheimer's disease'. J Neurochem, 146 (66):649-669 [Details]
	(2017)	'Impaired expression of GABA transporters in the human Alzheimer's disease hippocampus, subiculum, entorhinal cortex and superior temporal gyrus' Fuhrer, T. E.,Palpagama, T. H.,Waldvogel, H. J.,Synek, B. J. L.,Turner, C.,Faull, R. L.,Kwakowsky, A. (2017) 'Impaired expression of GABA transporters in the human Alzheimer's disease hippocampus, subiculum, entorhinal cortex and superior temporal gyrus'. Neuroscience, 351 :108-118 [Details]
	(2017)	'Towards a Better Understanding of GABAergic Remodeling in Alzheimer's Disease' Govindpani, K.,Calvo-Flores Guzman, B.,Vinnakota, C.,Waldvogel, H. J.,Faull, R. L.,Kwakowsky, A. (2017) 'Towards a Better Understanding of GABAergic Remodeling in Alzheimer's Disease'. Int J Mol Sci, 18 (88) [Details]
	(2016)	'Treatment of beta amyloid 1-42 (Abeta(1-42))-induced basal forebrain cholinergic damage by a non-classical estrogen signaling activator in vivo' Kwakowsky, A.,Potapov, K.,Kim, S.,Peppercorn, K.,Tate, W. P.,Abraham, I. M. (2016) 'Treatment of beta amyloid 1-42 (Abeta(1-42))-induced basal forebrain cholinergic damage by a non-classical estrogen signaling activator in vivo'. Sci Rep, 6 [Details]
	(2016)	'Effect of Estradiol on Neurotrophin Receptors in Basal Forebrain Cholinergic Neurons: Relevance for Alzheimer's Disease' Kwakowsky, A.,Milne, M. R.,Waldvogel, H. J.,Faull, R. L. (2016) 'Effect of Estradiol on Neurotrophin Receptors in Basal Forebrain Cholinergic Neurons: Relevance for Alzheimer's Disease'. Int J Mol Sci, 17 (1212) [Details]
	(2015)	'The spatiotemporal segregation of GAD forms defines distinct GABA signaling functions in the developing mouse olfactory system and provides novel insights into the origin and migration of GnRH neurons' Vastagh, C.,Schwirtlich, M.,Kwakowsky, A.,Erdelyi, F.,Margolis, F. L.,Yanagawa, Y.,Katarova, Z.,Szabo, G. (2015) 'The spatiotemporal segregation of GAD forms defines distinct GABA signaling functions in the developing mouse olfactory system and provides novel insights into the origin and migration of GnRH neurons'. Dev Neurobiol, 75 (33):249-70 [Details]
	(2015)	'Estradiol modulation of neurotrophin receptor expression in female mouse basal forebrain cholinergic neurons in vivo' Milne, M. R.,Haug, C. A.,Abraham, I. M.,Kwakowsky, A. (2015) 'Estradiol modulation of neurotrophin receptor expression in female mouse basal forebrain cholinergic neurons in vivo'. Endocrinology, 156 (22):613-26 [Details]
	(2014)	'Non-classical effects of estradiol on cAMP responsive element binding protein phosphorylation in gonadotropin-releasing hormone neurons: mechanisms and role' Kwakowsky, A.,Cheong, R. Y.,Herbison, A. E.,Abraham, I. M. (2014) 'Non-classical effects of estradiol on cAMP responsive element binding protein phosphorylation in gonadotropin-releasing hormone neurons: mechanisms and role'. Front Neuroendocrinol, 35 (11):31-41 [Details]
	(2013)	'Neuroprotective effects of non-classical estrogen-like signaling activators: from mechanism to potential implications' Kwakowsky, A.,Koszegi, Z.,Cheong, R. Y.,Abraham, I. M. (2013) 'Neuroprotective effects of non-classical estrogen-like signaling activators: from mechanism to potential implications'. CNS Neurol Disord Drug Targets, 12 (88):1219-25 [Details]
	(2013)	'Tracking of single receptor molecule mobility in neuronal membranes: a quick theoretical and practical guide' Kwakowsky, A.,Potapov, D.,Abraham, I. M. (2013) 'Tracking of single receptor molecule mobility in neuronal membranes: a quick theoretical and practical guide'. J Neuroendocrinol, 25 (1111):1231-7 [Details]
	(2012)	'The role of cAMP response element-binding protein in estrogen negative feedback control of gonadotropin-releasing hormone neurons' Kwakowsky, A.,Herbison, A. E.,Abraham, I. M. (2012) 'The role of cAMP response element-binding protein in estrogen negative feedback control of gonadotropin-releasing hormone neurons'. J Neurosci, 32 (3333):11309-17 [Details]
	(2012)	'Estradiol acts directly and indirectly on multiple signaling pathways to phosphorylate cAMP-response element binding protein in GnRH neurons' Cheong, R. Y.,Kwakowsky, A.,Barad, Z.,Porteous, R.,Herbison, A. E.,Abraham, I. M. (2012) 'Estradiol acts directly and indirectly on multiple signaling pathways to phosphorylate cAMP-response element binding protein in GnRH neurons'. Endocrinology, 153 (88):3792-803 [Details]
	(2011)	'GABAergic signaling in primary lens epithelial and lentoid cells and its involvement in intracellular Ca2+ modulation' Schwirtlich, M.,Kwakowsky, A.,Emri, Z.,Antal, K.,Lacza, Z.,Cselenyak, A.,Katarova, Z.,Szabo, G. (2011) 'GABAergic signaling in primary lens epithelial and lentoid cells and its involvement in intracellular Ca2+ modulation'. Cell Calcium, 50 (44):381-92 [Details]
	(2008)	'GABA neurotransmitter signaling in the developing mouse lens: dynamic regulation of components and functionality' Kwakowsky, A.,Schwirtlich, M.,Kooy, F.,Abraham, I.,Mate, Z.,Katarova, Z.,Szabo, G. (2008) 'GABA neurotransmitter signaling in the developing mouse lens: dynamic regulation of components and functionality'. Dev Dyn, 237 (1212):3830-41 [Details]
	(2007)	'GAD isoforms exhibit distinct spatiotemporal expression patterns in the developing mouse lens: correlation with Dlx2 and Dlx5' Kwakowsky, A.,Schwirtlich, M.,Zhang, Q.,Eisenstat, D. D.,Erdelyi, F.,Baranyi, M.,Katarova, Z. D.,Szabo, G. (2007) 'GAD isoforms exhibit distinct spatiotemporal expression patterns in the developing mouse lens: correlation with Dlx2 and Dlx5'. Dev Dyn, 236 (1212):3532-44 [Details]

Books

	Year	Publication
	(2023)	Neuronal Network Dysfunction in Neurodegenerative Disorders. A. Kwakowsky, A.A. Prasad, F. Peña-Ortega, S.A.O. Lim (2023) Neuronal Network Dysfunction in Neurodegenerative Disorders. Switzerland: Frontiers in Neuroscience. [DOI] [Details]

Book Chapters

	Year	Publication
	(2023)	'EAAT2 as a therapeutic research target in Alzheimer¿s disease: a systematic review' Oliver W.G. Wood, Jason H. Yeung, Clinton Turner, Richard L.M. Faull, Andrea Kwakowsky (2023) 'EAAT2 as a therapeutic research target in Alzheimer¿s disease: a systematic review' In: 1. Neuronal Network Dysfunction in Neurodegenerative Disorders. Switzerland: Frontiers in Neuroscience. [DOI] [Details]
	(2022)	'The interplay between beta amyloid 1-42 (Aß1-42)-induced hippocampal inflammatory response, p-tau, vascular pathology and their synergistic contributions to neuronal death and behavioral deficits' Beatriz Calvo-Flores Guzman, Tessa Chaffey, Thulani Palpagama, Sarah Waters, Jordi Boix, Warren P. Tate, Katie Peppercorn, Michael Dragunow, Henry J. Waldvogel, Richard L.M. Faull, Andrea Kwakowsky (2022) 'The interplay between beta amyloid 1-42 (Aß1-42)-induced hippocampal inflammatory response, p-tau, vascular pathology and their synergistic contributions to neuronal death and behavioral deficits' In: 5. Beta Amyloid: From Physiology to Pathogenesis. Switzerland: Frontiers in Molecular Neuroscience. [DOI] [Details]
	(2022)	'EAAT2 expression in the hippocampus, subiculum, entorhinal cortex and superior temporal gyrus in Alzheimer¿s disease' Jason H. Yeung, Thulani H. Palpagama, Oliver W.G. Wood, Clinton Turner, Henry J. Waldvogel, Richard L.M. Faull, Andrea Kwakowsky (2022) 'EAAT2 expression in the hippocampus, subiculum, entorhinal cortex and superior temporal gyrus in Alzheimer¿s disease' In: 4. The Known, the Unknown, and the Future of Glutamate Transporters. Switzerland: Frontiers in Cellular Neuroscience. [DOI] [Details]
	(2022)	'The role of neuroinflammation in Huntington¿s disease' Thulani Palpagama, Henry J. Waldvogel, Richard L.M. Faull, Andrea Kwakowsky (2022) 'The role of neuroinflammation in Huntington¿s disease' In: Advances in Biomedical and Molecular Neuroscience. Switzerland: Frontiers in Molecular Neuroscience. [DOI] [Details]
	(2020)	'The acute effects of amyloid-beta 1-42 on glutamatergic receptor and transporter expression in the mouse hippocampus' Jason H. Yeung, Thulani H. Palpagama, Warren P. Tate, Katie Peppercorn, Henry J. Waldvogel, Richard L.M. Faull, Andrea Kwakowsky (2020) 'The acute effects of amyloid-beta 1-42 on glutamatergic receptor and transporter expression in the mouse hippocampus' In: Circuit Mechanisms of Neurodegenerative Diseases. Switzerland: Frontiers in Neuroscience. [DOI] [Details]

Edited Books

	Year	Publication
	(2023)	Estrogen effects on fertility and neurodegeneration - classical versus non-classical actions. Zsuzsanna Nagy, Allan Herbison, Andrea Kwakowsky, Gergely Kovacs and Klaudia Barabas (Ed.). (2023) Estrogen effects on fertility and neurodegeneration - classical versus non-classical actions Estrogen effects on fertility and neurodegeneration - classical versus non-classical actions. Switzerland: Frontiers. [DOI] [Details]

Other Journals

	Year	Publication
	(2022)	'The relationship between caffeine and cognition. E Scholarly Community Encyclopedia' Mukish M Yelanchezian, Henry J. Waldvogel, Andrea Kwakowsky (2022) 'The relationship between caffeine and cognition. E Scholarly Community Encyclopedia' E Scholarly Community Encyclopedia, . [Details]
	(2023)	'Potassium-Chloride Cotransporter 2 and sodium-potassium-chloride cotransporter 1 in neurological disorders' Patricia Lam, Julia Newland, Richard L.M. Faull, Andrea Kwakowsky (2023) 'Potassium-Chloride Cotransporter 2 and sodium-potassium-chloride cotransporter 1 in neurological disorders' E Scholarly Community Encyclopedia, . [Details]

Blog

	Year	Publication
	(2019)	Celebrating kiwi women in dementia research. Andrea Kwakowsky (2019) Celebrating kiwi women in dementia research. Blog [Details]

Teaching Interests

Pharmacology
Neurodegnerative disorders

Modules Taught

Term/Year	Module Title	Module Code
1/2023	Drugs and Disease I	PM309
2/2023	Advanced Pharmacology	PM3103
2/2023	Molecular Pharmacology and Signalling	PM210
2/2023	Neuropharmacology and Therapeutics	PM5105
1/2023	Fundamental Concepts in Pharmacology	PM208
2/2023	Pharmacology for Podiatrist	PO3103
2/2023	Experimental Neuropharmacology	PM5103
2/2023	Biomed Mini Projects	PM325
1/2023	Bachelor of Science, Research project	PM431
1/2023	Course Director MSc Neuropharmacology	MSc Neuropharmacology