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Medicine
Dr Karl McCullagh
B.Sc, M.Sc, Ph.D.
Contact Details
LECTURER ABOVE THE BAR
Dept of Physiology
Quadrangle Building
NUI Galway
T: Ext. 4220
E: karl.mccullagh@nuigalway.ie
Dept of Physiology
Quadrangle Building
NUI Galway
T: Ext. 4220
E: karl.mccullagh@nuigalway.ie
Lecturer / Principal Investigator
Department of Physiology
National University of Ireland Galway (NUIG)
T: 091-49-4220
E: karl.mccullagh@nuigalway.ie
Department of Physiology
National University of Ireland Galway (NUIG)
T: 091-49-4220
E: karl.mccullagh@nuigalway.ie
Biography
Research Interests
Peer Reviewed Journals
| Year | Publication | |
|---|---|---|
| (2019) | 'The panniculus carnosus muscle: A novel model of striated muscle regeneration that exhibits sex differences in the mdx mouse'
Bahri OA;Naldaiz-Gastesi N;Kennedy DC;Wheatley AM;Izeta A;McCullagh KJA; (2019) 'The panniculus carnosus muscle: A novel model of striated muscle regeneration that exhibits sex differences in the mdx mouse'. Scientific Reports, 9 (1) [DOI] [ARAN Link] [Details] |
|
| (2019) | 'The panniculus carnosus muscle: A novel model of striated muscle regeneration that exhibits sex differences in the mdx mouse'
Bahri, OA,Naldaiz-Gastesi, N,Kennedy, DC,Wheatley, AM,Izeta, A,McCullagh, KJA (2019) 'The panniculus carnosus muscle: A novel model of striated muscle regeneration that exhibits sex differences in the mdx mouse'. Scientific Reports, 9 [DOI] [Details] |
|
| (2018) | 'The panniculus carnosus muscle: an evolutionary enigma at the intersection of distinct research fields'
Karl McCullagh (2018) 'The panniculus carnosus muscle: an evolutionary enigma at the intersection of distinct research fields'. Journal Of Anatomy, [DOI] [Details] |
|
| (2016) | 'Endothelial nitric oxide synthase induces heat shock protein HSPA6 (HSP70B') in human arterial smooth muscle cells'
McCullagh, KJA,Cooney, R,O'Brien, T (2016) 'Endothelial nitric oxide synthase induces heat shock protein HSPA6 (HSP70B') in human arterial smooth muscle cells'. Nitric Oxide-Biology And Chemistry, 52 :41-48 [DOI] [Details] |
|
| (2014) | 'Coaxing Stem Cells for Skeletal Muscle repair'
McCullagh, KJA and Perlingeiro, R (2014) 'Coaxing Stem Cells for Skeletal Muscle repair'. Advanced Drug Delivery Reviews, [Details] |
|
| (2013) | 'Liposomal surface coatings of metal stents for efficient non-viral gene delivery to the injured vasculature'
Ganly S, Hynes SO, Sharif F, Aied A, Barron V, McCullagh K, McMahon J, McHugh P, Crowley J, Wang W, O'Brien T, Greiser U (2013) 'Liposomal surface coatings of metal stents for efficient non-viral gene delivery to the injured vasculature'. J Control Release, 167 (2):109-119 [Details] |
|
| (2012) | 'Gene-eluting stents: non-viral, liposome-based gene delivery of eNOS to the blood vessel wall in vivo results in enhanced endothelialization but does not reduce restenosis in a hypercholesterolemic model'
Sharif, F,Hynes, SO,McCullagh, KJA,Ganley, S,Greiser, U,McHugh, P,Crowley, J,Barry, F,O'Brien, T (2012) 'Gene-eluting stents: non-viral, liposome-based gene delivery of eNOS to the blood vessel wall in vivo results in enhanced endothelialization but does not reduce restenosis in a hypercholesterolemic model'. Gene Therapy, 19 :321-328 [DOI] [Details] |
|
| (2012) | 'Can a young muscle’s stem cell secretome prolong our lives?'
McCullagh, Karl JA (2012) 'Can a young muscle’s stem cell secretome prolong our lives?'. Stem Cell Research & Therapy, 3 (3) [ARAN Link] [Details] |
|
| (2012) | 'Gene-Eluting Stents: liposome-based eNOS enhances re-endothelialisation but does not prevent restenosis in a hypercholesterolemic model'
Sharif F, Hynes S, McCullagh KJA, Ganley S, Geiser U, McHugh P, Crowley J, Barry F, O'Brien T. (2012) 'Gene-Eluting Stents: liposome-based eNOS enhances re-endothelialisation but does not prevent restenosis in a hypercholesterolemic model'. Gene Therapy. Impact Factor 4.8, [Details] |
|
| (2010) | 'Syncoilin modulates peripherin filament networks and is necessary for large- calibre motor neurons'
WT Clarke, B Edwards, KJA McCullagh, MW Kemp, C Moorwood, DL Sherman, M Burgress and KE Davies. (2010) 'Syncoilin modulates peripherin filament networks and is necessary for large- calibre motor neurons'. Journal of Cell Science. Cover Issue (Impact factor:6.1), 123 :2543-2552 [Details] |
|
| (2008) | 'Analysis of skeletal muscle function in the C57BL6/SV129 syncoilin knockout mouse'
Karl JA McCullagh, Ben Edwards, Matthew W. Kemp, Laura C. Giles, Matthew Burges and Kay E. Davies (2008) 'Analysis of skeletal muscle function in the C57BL6/SV129 syncoilin knockout mouse'. Mammalian Genome (Impact factor: 2.94), 19 (5):339-351 [Details] |
|
| (2007) | 'Intermediate filament-like protein syncoilin in normal and myopathic striated muscle. Neuromuscular Disorders'
Karl JA McCullagh, Ben Edwards, Richard M. Lovering, Ellen Poon, Denise Paulin and Kay E Davies. (2007) 'Intermediate filament-like protein syncoilin in normal and myopathic striated muscle. Neuromuscular Disorders'. Neuromuscular Disorders (Impact factor:2.98), 17 ((11-12)):970-979 [Details] |
|
| (2007) | 'A naturally occurring calcineurin variant inhibits FoxO activity and enhances skeletal muscle regeneration'
Lara-Pezzi E, Paul A, Winn N, McCullagh KJA, Slominsky E, Paola Santini M, Mourkioti F, Fukushima S, Suzuki K and Rosenthal N. (2007) 'A naturally occurring calcineurin variant inhibits FoxO activity and enhances skeletal muscle regeneration'. J. Cell. Biol (Impact factor:9.57), 179 (6):1205-1218 [Details] |
|
| (2005) | 'Muscular dystrophies related to the cytoskeleton/nuclear envelope'
Nowak K, McCullagh K, Poon E, Davies KE. (2005) 'Muscular dystrophies related to the cytoskeleton/nuclear envelope'. Novartis Found Symp discussion 112-7, 227-30. Review, :227-230 [Details] |
|
| (2005) | 'Utrophin upregulation in Duchenne muscular dystrophy'
Hirst, RC, McCullagh, KJA., Davies KE (2005) 'Utrophin upregulation in Duchenne muscular dystrophy'. Acta Myologica Review, 24 (3):209-216 [Details] |
|
| (2004) | 'NFAT is a nerve activity sensor in skeletal muscle and controls activity-dependent myosin switching'
McCullagh KJ, Calabria E, Pallafacchina G, Ciciliot S, Serrano AL, Argentini C, Kalhovde JM, Lomo T, Schiaffino S (2004) 'NFAT is a nerve activity sensor in skeletal muscle and controls activity-dependent myosin switching'. Proc Natl Acad Sci U S A. (Impact factor 9.4), 20 (101(29)):10590-10595 [Details] |
|
| (2001) | 'Localized IGF-1 transgene expression sustains hypertrophy and regeneration in senescent skeletal muscle'
Musaro, A., McCullagh, K., Paul, A., Houghton, L., Dobrowolny, G., Molinaro, M., Barton, E.R., Sweeney, H.L. : Rosenthal, N. (2001) 'Localized IGF-1 transgene expression sustains hypertrophy and regeneration in senescent skeletal muscle'. Nature Genetics . (Impact factor 34.3), 27 (2):195-200 [Details] |
|
| (2000) | 'Revisiting calcineurin and human heart failure'
Tsao L, Neville C, Musaro A, McCullagh KJA, Rosenthal N (2000) 'Revisiting calcineurin and human heart failure'. Nature Medicine (Impact factor 27.1), 6 (1):2-3 [Details] |
|
| (1999) | 'IGF-1 induces skeletal myocyte hypertrophy through calcineurin in association with GATA-2 and NF-ATc1'
Musarò, Antonio, Karl J.A. McCullagh, Frank Naya, Eric N.Olson and Nadia Rosenthal (1999) 'IGF-1 induces skeletal myocyte hypertrophy through calcineurin in association with GATA-2 and NF-ATc1'. Nature (Impact factor 34.5), 400 (6744):581-585 [Details] |
|
| (1998) | 'Training intensity dependent and tissue specific increases in lactate uptake and MCT1 in heart and muscle'
Baker, S.K., McCullagh, K.J.A., Bonen, A. (1998) 'Training intensity dependent and tissue specific increases in lactate uptake and MCT1 in heart and muscle'. Journal of Applied Physiology, 84 :987-994 [Details] |
|
| (1998) | 'Short-term training increases human muscle MCT1 and femoral venous lactate in relation to muscle lactate'
Bonen, A., K. J. A. McCullagh, C. T. Putman, E. Hultman, N. L. Jones, G. J. F. Heigenhauser. (1998) 'Short-term training increases human muscle MCT1 and femoral venous lactate in relation to muscle lactate'. American Journal of Physiology (Endocrinol. Metab.), 274 :E102-E107 [Details] |
|
| (1997) | 'Chronic electrical stimulation increases MCT1 and lactate uptake in red and white skeletal muscle'
McCullagh, K. J. A., Poole, R. C., Halestrap, A. P., Tipton, K. F., O'Brien, M., : Bonen, A. (1997) 'Chronic electrical stimulation increases MCT1 and lactate uptake in red and white skeletal muscle'. American Journal of Physiology, (Endocrinol. Metab.)(Impact factor: 4.4), 273 :e239-e246 [Details] |
|
| (1997) | 'Cellular and subcellular expression of the monocarboxylate transporter MCT1 in rat heart'
Johannsson, E.,Nagelhus, E. A., McCullagh, K. J. A., Sejersted, O. M.,Blackstad, T.W.,Bonen, A., : Ottersen, O. P. (1997) 'Cellular and subcellular expression of the monocarboxylate transporter MCT1 in rat heart'. Circulation Research, 80 :400-407 [Details] |
|
| (1996) | 'Reciprocal GLUT1 and GLUT4 expression and glucose transport in denervated muscles'
Handberg, A., Megeney, L. A., McCullagh, K. J. A., Kayser, L. : Bonen, A. (1996) 'Reciprocal GLUT1 and GLUT4 expression and glucose transport in denervated muscles'. American Journal of Physiology (Endocrinol. Metab. 34), 271 :E50-E57 [Details] |
|
| (1996) | 'Effect of overexpressing GLUT-1 and GLUT-4 on insulin- and contraction-stimulated glucose transport in muscle'
Johannsson, E., McCullagh, K. J. A., Han, X. X., Fernando, P. K., Jensen, J., Dahl, H. A. : Bonen, A. (1996) 'Effect of overexpressing GLUT-1 and GLUT-4 on insulin- and contraction-stimulated glucose transport in muscle'. American Journal of Physiology (Endocrinol. Metab. 34), 271 :E547-E555 [Details] |
|
| (1996) | 'Chronic muscle stimulation increases lactate transport in rat skeletal muscle'
McCullagh, K. J. A., Juel, C., O'Brien, M. : Bonen, A. ( (1996) 'Chronic muscle stimulation increases lactate transport in rat skeletal muscle'. Molecular Cellular Biochemistry, 156 :51-57 [Details] |
|
| (1996) | 'The role of the lactate transporter (MCT1) in skeletal muscles'
McCullagh, K. J. A., Poole, R. C., Halestrap, A. P., O'Brien, M. : Bonen, A. (1996) 'The role of the lactate transporter (MCT1) in skeletal muscles'. American Journal of Physiology.(Endocrinol. Metab. 34), 271 :e143-e150 [Details] |
|
| (1995) | 'Reduced lactate transport in denervated rat skeletal muscle'
McCullagh, K. J. A. : Bonen, A. (1995) 'Reduced lactate transport in denervated rat skeletal muscle'. American Journal of Physiology (Reg. Integ. Comp. Physiol. 37), 268 :R884-R888 [Details] |
|
| (1995) | 'L(+)-lactate binding to a protein in rat skeletal muscle plasma membranes. '
McCullagh, K. J. A. : Bonen, A. (1995) 'L(+)-lactate binding to a protein in rat skeletal muscle plasma membranes. '. Canadian Journal of Applied Physiology, 20 :112-124 [Details] |
|
| (1994) | 'Effects of exercise on lactate transport into mouse skeletal muscles'
Bonen, A. : McCullagh, K. J. A. ( (1994) 'Effects of exercise on lactate transport into mouse skeletal muscles'. Canadian Journal of Applied Physiology, 19 :275-285 [Details] |
Conference Publications
| Year | Publication | |
|---|---|---|
| (2015) | 1st NUIG Microcirculation & Angiogenesis Symposium
BAHRI OA, WHEATLEY AM, McCULLAGH KJA (2015) Morphometric and capillary analyses of panniculus carnosus skeletal muscle in the mdx mouse 1st NUIG Microcirculation & Angiogenesis Symposium [Details] |
|
| (2015) | Cell Symposia: Exercise Metabolism
Bahri, O.A.,McCarthy,S.,Gao,G. and McCullagh, K.J.A. (2015) Adenoassociated viral delivery of serca2a into mdx hindlimb skeletal muscles . In: Cell eds. Cell Symposia: Exercise Metabolism Amsterdam, The Netherlands, , 12-JUL-15 - 14-JUL-15 [Details] |
|
| (2013) | Royal Academy of Medicine Ireland: Biomedical Science Meeting
McCarthy, SD McCullagh, KJA (2013) Gene Therapy for Muscular Dystrophy in an mdx mouse model Royal Academy of Medicine Ireland: Biomedical Science Meeting [Details] |
Conference Contributions
| Year | Publication | |
|---|---|---|
| (2013) | American College of Sports Medicine 60th Annual Meeting & 4th World Congress on Exercise is Medicine,
Dr Richard Lovering (USA), Dr Karl McCullagh (IRE), Dr. Brent Baker (USA) (2013) Symposium: Functional Outcomes in Skeletal Muscle Disorders: Integrated Biological Evidence. [Invited Oral Presentation], American College of Sports Medicine 60th Annual Meeting & 4th World Congress on Exercise is Medicine, Indianapolis, Indiana, USA , 28-MAY-13 - 01-JUN-13. [Details] |
Abstract
| Year | Publication | |
|---|---|---|
| (2016) | Gene Therapy for Muscular Dystrophy in an mdx Mouse Model.
McCarthy, SD,McCullagh, KJA (2016) Gene Therapy for Muscular Dystrophy in an mdx Mouse Model. Abstract [Details] |
|
| (2016) | Adeno-Associated Viral Delivery of Sarcoplasmic Reticulum Ca2+-ATPase (SERCA2A) Pump into the Pre-Clinical mdx Mouse Model of Duchennes Muscular Dystrophy.
Bahri, OA,McCarthy, SD,McCullagh, KJA (2016) Adeno-Associated Viral Delivery of Sarcoplasmic Reticulum Ca2+-ATPase (SERCA2A) Pump into the Pre-Clinical mdx Mouse Model of Duchennes Muscular Dystrophy. Abstract [Details] |
ANET/COS
| Year | Publication | |
|---|---|---|
| (2016) | Highly regenerative panniculus carnosus skeletal muscle in the pre-clinical mdx model of DMD.
Bahri, OA,Nalaiz-Gastesi, N,Wheatley, AM,Izeta, A,McCullagh, KJA (2016) Highly regenerative panniculus carnosus skeletal muscle in the pre-clinical mdx model of DMD. ANET/COS [Details] |
Editorial
| Year | Publication | |
|---|---|---|
| (2012) | Can a young muscle's stem cell secretome prolong our lives?.
McCullagh, KJA (2012) Can a young muscle's stem cell secretome prolong our lives?. LONDON: Editorial [DOI] [Details] |
|
| (2012) | Can a young muscle's stem cell secretome prolong our lives?.
McCullagh, KJA (2012) Can a young muscle's stem cell secretome prolong our lives?. Editorial [DOI] [Details] |
Meeting
| Year | Publication | |
|---|---|---|
| (2013) | Gene delivery and targeting nos as therapy for muscular dystrophy.
McCarthy, SD,McCullagh, KJA (2013) Gene delivery and targeting nos as therapy for muscular dystrophy. Meeting [Details] |
Reviews
| Year | Publication | |
|---|---|---|
| (2018) | The panniculus carnosus muscle: an evolutionary enigma at the intersection of distinct research fields.
Naldaiz-Gastesi, N;Bahri, OA;de Munain, AL;McCullagh, KJA;Izeta, A (2018) The panniculus carnosus muscle: an evolutionary enigma at the intersection of distinct research fields. HOBOKEN: Reviews [DOI] [Details] |
|
| (2015) | Coaxing stem cells for skeletal muscle repair.
McCullagh, KJA,Perlingeiro, RCR (2015) Coaxing stem cells for skeletal muscle repair. Reviews [DOI] [Details] |
Honours and Awards
| Year | Title | Awarding Body | |
|---|---|---|---|
| 2018 | Irish Research Council PhD Scholarship Programme | Irish Research Council | |
| 2013 | PhD Scholarship Funding | Saudi Arabia Scholarship programme | |
| 2010 | HRB Health Research Award | Health Research Board Ireland | |
| 2000 | Marie Curie Postdoctoral Fellowship | Marie Curie Postdoctoral fellowship | |
| 2000 | EMBO Postdoctoral Longterm Fellowship | European Molecular Biological Organization | |
| 1996 | Trinity College Dublin Postgraduate Award | Trinity College Dublin | |
| 1993 | Canadian Society of Exercise Physiology Graduate Research award | Canadian Society of Exercise Physiology | |
| 1990 | Dalhousie University Graduate Fellowship | Dalhousie University, Canada | |
| 1990 | Dalhousie University Teaching Assistantship | Dalhousie University, Canada |
Professional Associations
| Association | Function | From / To | |
|---|---|---|---|
| The Physiological Society | Academic Member | 01-JAN-11 / |
Committees
| Committee | Function | From / To | |
|---|---|---|---|
| Department of Physiology Research Committee | Chair | 01-SEP-19 / | |
| College of Medicine Research Committee | Member | 01-JAN-19 / | |
| School of Medicine Research Committee | Member | 01-JAN-18 / | |
| Genetically Modified Organisms Committee (NUIG) | Member | 01-JAN-12 / |
Languages
| Language | |
|---|---|
| Italian |
Community Engagement
| Title | Type | From / To | |
|---|---|---|---|
| Other | NUIG Junior Rugby Academy Coach | 01-SEP-18 / | |
| Other | Galway Bay Rugby Club_Coach | 01-SEP-12 / 31-MAY-18 |
Recent Postgraduate Students
| Graduation | Name | Degree | Primary Supervisor | |
|---|---|---|---|---|
| 2012 | Ruth Concannon | Msc | ||
| 2016 | Jaspreet | Msc | Y | |
| 2013 | Enda Clinton | Msc | ||
| 2014 | Jessica Nulty | Msc | ||
| 2009 | Orla Hughes | Msc | ||
| 2010 | Waq UI Hassan | Msc |
Current Postgraduate Students (Research)
| Student | Degree Type | Type | |
|---|---|---|---|
| Donna Kennedy | Doctorate - Structured Ph.D (Medicine) | Supervisor |
Modules Taught
| Term/Year | Module Title | Module Code | Subject / Desc | |
|---|---|---|---|---|
| 2nd Semester | Cardiovascular Physiology | SI218 | ||
| 1st Semester | Biomedical Science Seminar and Essay Assignments | BO1 | ||
| 1st Semester | Human Body Function | SI317 | ||
| 1st Semester | Principles of Physiology | MD135 | 10ECT Module | |
| Semester 1 & 2 | Research Project | SI435 | Semester 1: Literature Review; Semester 2: Wet lab Project, Theses and Oral Presentation | |
| 1st Semester | Therapeutics: Gene & Cell Therapy | SI436 | ||
| 1st Semester | Nerve and Muscle | SI207 | ||
| 1st Semester | Muscle & Nerve | NU249 | ||
| 2nd Semester | MSc Regenerative Medicine | 1MSR1 | Muscle Regeneration |
