Our Place and Facilities

The team have been collaborating for more than a decade and have developed a comprehensive and innovative diagnostic and therapeutic approach to coronary and structural heart diseases that have contributed to improved patient care. Located in Galway the team are in the very heart of the “European Silicon Valley” where they will collaborate with numerous NUI Galway centres of excellence, such as CURAM, REMIDI, Bioinnovate, HRB- Clinical Research Facility.

This team brings more than four decades of expertise in clinical trials, education and innovation to industry and academic partners and are connected with strong regulatory background of experts in device, diagnostic and therapeutic device.

Angiography Core Lab

A. Angiography core lab (Coronary and Peripheral)

• 2D and 3D QCA measurements
• Bifurcation dedicated QCA
• Curvature and compliance analysis
• Video-densitometry – aortic and mitral regurgitation measurements
• Quantitative Flow Ratio
• Pre-adjudication angiographic analysis of Event Cases (Based on QFR according to ARC-2 definition)
• Assessment of Device Success
•  Anatomic Syntax Score, Logistic Syntax Score, Syntax Score II and Syntax Score III
• MI Syntax Score
• CABG Syntax Score
• Residual Syntax Score
• Functional Syntax Score

B. Angiography (post structural interventions)

• Quantitative Angiography of PVL (Videodensitometic) analysis of AR (TAVI)
• Depth of Implantation (TAVI)
• Quantitative Aortography mitral (TMVR)

Intravascular imaging core lab

• Fractional Flow Reserve (FFR) measurements
• Coronary Flow Reserve (CFR) measurements
• Instantaneous Wave Free Ratio (IFR)
• Pressure Velocity Analysis
• Epicardial conductance
• Microcirculatory conductance
• Zero flow pressure

 Coronary physiology core lab

• Fractional Flow Reserve (FFR) measurements
• Coronary Flow Reserve (CFR) measurements
• Instantaneous Wave Free Ratio (IFR)
• Pressure Velocity Analysis
• Epicardial conductance
• Microcirculatory conductance
• Zero flow pressure
• Forward wave distal to PCI site
• Backward Expansion Wave
• Index of Myocardial Resistance (IMR)

Comprehensive Combined Multi-modality Imaging and Simulation

• Shear stress analysis
• 4D Wall Stress analysis
• Von Misses stress analysis
• Fusion Imaging of MSCT plus NIRS, OCT plus VH-IVUS, OCT plus IVUS-Echogenicity

Comprehensive statistical reporting specifically adapted for Imaging data

• Mixed model
• Clustering
• Bayesian approach
• Linear –regression
• Bland-Altman

High Bleeding Risk Core Lab

• DAPT Score
• PRECISE DAPT Score
• ACUITY Score
• CRUSADE Score
• PARIS Score

Echocardiography core lab

Our Echo Core lab provides accurate and reproducible qualitative and quantitative assessments of various cardiovascular Echocardiographic measurements in clinical trials. With more than two decades of experience and expertise, our Echo core lab services include:

Cardio-oncology core lab and cardiac Safety measurements

• Serial Echocardiographic Chamber quantification analysis:
• LV Tri-plane Global Longitudinal Strain, LV size and ejection fraction
• RV Global Longitudinal Strain

Conventional Echocardiography core lab

• Two-dimensional and Doppler Echocardiography measurements
• Valvular hemodynamic analysis – device success
• Dedicated Valvular Regurgitation analysis (combination of Echocardiographic and Quantitative Angiographic analysis of AR)
• Stress Echocardiography and Regional Wall Motion Analysis
• 2D Contrast Echocardiography Analysis
• Tissue Doppler imaging Analysis

4D echocardiography measurements of LV size and ejection fraction

• 4D LV chamber quantification
• 4D RV chamber quantification
• 4D Structural Heart Analysis (Dynamic Echocardiographic for Mitral Pre-procedural Planning)