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Biological and Chemical Sciences

Prof Conor O'Byrne

BSC PHD

 
researcher
 

Biography

BIOGRAPHY:

  • 2019-present: Personal Professor of Microbiology, NUI Galway, IRELAND.
  • 2014-2019: Senior Lecturer, Microbiology, NUI Galway, IRELAND. 
  • 2009-2014: Vice dean for Internationalisation, College of Science, NUI Galway, IRELAND.
  • 2002-2009: Lecturer, Microbiology, NUI Galway, IRELAND. 
  • 2000-2002: University Lecturer, University of Aberdeen, SCOTLAND. 
  • 1997-2000: ACT(R) Post Doctoral Fellow, University of Aberdeen, SCOTLAND. 
  • 1994-1997: Post Doctoral Researcher, Colworth Laboratory, Unilever Plc, ENGLAND. 
  • 1990-1994: PhD, University of Dundee (Biochemistry), SCOTLAND. 
  • 1986-1990: BSc, Microbiology, University College Cork, IRELAND .
RESEARCH INTERESTS:

  • Bacterial food-borne pathogens
  • Listeria monocytogenes
  • Escherichia coli
  • Molecular responses to stress 
  • Osmoregulation
  • Acid stress responses
  • Sigma factors
  • Mechanisms of environmental persistence
  • Transcriptional responses to environmental stimuli

Research Interests

RESEARCH INTERESTS:

  • Bacterial food-borne pathogens
  • Listeria monocytogenes
  • Escherichia coli
  • Molecular responses to stress 
  • Osmoregulation
  • Acid stress responses
  • Sigma factors
  • Mechanisms of environmental persistence
  • Transcriptional responses to environmental stimuli
SYNOPSIS OF ACTIVITY:

The Bacterial Stress Response Group (www.nuigalway.ie/microbiology/cpoblab/) was established in 2000 in the University of Aberdeen and then relocated to NUI Galway in 2002. Since the group’s inception 9 PhD students, 8 MSc students and over 60 final year project students have successfully completed their degrees under my supervision. The group has attracted significant research income totalling more than 5 million euro, from a diverse range of sources including the NIH, food industry, the EU and SFI. The research from the group has been published extensively in highly-ranked international journals and presented at national and international symposia, with over 100 scientific communications in total.

Research activity within the group centres on an interest in the mechanisms that food-borne bacterial pathogens use to respond and adapt to environmental perturbations. Research projects have focussed on important bacterial pathogens including Salmonella Typhimurium, Escherichia coli and Listeria monocytogenes, all of which cause significant food-borne infections in humans. This research is essential to develop a more complete understanding of how bacterial cells grow and persist in the environment. An understanding of how these pathogens adapt to their environment will also be central to any strategy aimed at curbing their growth both within the host and within the food-chain.

Currently the Bacterial Stress Response Group consists of 5 postgraduate students (all registered for PhD degrees). Several projects focus on understanding the molecular responses to stress in the human pathogen Listeria monocytogenes, including its responses to oxygen depletion, acidic conditions, increased osmolarity, and light. Another research avenue within the group at present is the identification of novel host association factors expressed within the gastrointestinal microbiota.

The group has a strong network of collaborators within Europe (University of Brigthon; University of St Andrews; University of Aberdeen; INRA, Dijon; Pasteur Institute, Paris; Technische Universitat Munchen, Germany; University of Milan; University of Turku, Finland), the US (Cornell; Harvard; and the University of North Carolina Charlotte) and Ireland (UCC; TCD; UCD). These collaborations have helped to secure research funding, they have supported student exchanges, exchange of research materials and expertise, and they have supported numerous joint publications. 

Peer Reviewed Journals

  Year Publication
(2024) 'A single point mutation in the Listeria monocytogenes ribosomal gene rpsU enables SigB activation independently of the stressosome and the anti-sigma factor antagonist RsbV'
Ma, Xuchuan and Tempelaars, Marcel H and Zwietering, Marcel H and Boeren, Sjef and O'Byrne, Conor P and den Besten, Heidy MW and Abee, Tjakko (2024) 'A single point mutation in the Listeria monocytogenes ribosomal gene rpsU enables SigB activation independently of the stressosome and the anti-sigma factor antagonist RsbV'. International Journal Of Food Microbiology, 15 [Details]
(2024) 'The impact of different acidic conditions and food substrates on Listeria monocytogenes biofilms development and removal using nanoencapsulated carvacrol'
Jina Yammine and Agapi I. Doulgeraki and Conor P. O'Byrne and Adem Gharsallaoui and Nour-Eddine Chihib and Layal Karam (2024) 'The impact of different acidic conditions and food substrates on Listeria monocytogenes biofilms development and removal using nanoencapsulated carvacrol'. International Journal of Food Microbiology, 416 [DOI] [Details]
(2023) 'The Virulence and Infectivity of Listeria monocytogenes Are Not Substantially Altered by Elevated SigB Activity'
Oliveira Ana H.,Tiensuu Teresa,Guerreiro Duarte,Tükenmez Hasan,Dessaux Charlotte,García-del Portillo Francisco,O’Byrne Conor,Johansson Jörgen (2023) 'The Virulence and Infectivity of Listeria monocytogenes Are Not Substantially Altered by Elevated SigB Activity'. Infection and Immunity, 91 (6) [Details]
(2023) 'Trehalose transport occurs via TreB in Listeria monocytogenes and it influences biofilm development and acid resistance'
Jialun Wu and Olivia McAuliffe and Conor P. O'Byrne (2023) 'Trehalose transport occurs via TreB in Listeria monocytogenes and it influences biofilm development and acid resistance'. International Journal of Food Microbiology, 394 [DOI] [Details]
(2023) 'A novel RofA-family transcriptional regulator, GadR, controls the development of acid resistance in Listeria monocytogenes'
Wu Jialun,McAuliffe Olivia,O'Byrne Conor P. (2023) 'A novel RofA-family transcriptional regulator, GadR, controls the development of acid resistance in Listeria monocytogenes'. mBio, 14 (6) [Details]
(2023) 'Manganese uptake mediated by the NRAMP-type transporter MntH is required for acid tolerance in Listeria monocytogenes'
Jialun Wu and Olivia McAuliffe and Conor P. O'Byrne (2023) 'Manganese uptake mediated by the NRAMP-type transporter MntH is required for acid tolerance in Listeria monocytogenes'. International Journal of Food Microbiology, 399 [DOI] [Details]
(2022) 'Listeria monocytogenes Requires the RsbX Protein To Prevent SigB Activation under Nonstressed Conditions'
Oliveira Ana H.,Tiensuu Teresa,Guerreiro Duarte N.,Tükenmez Hasan,Dessaux Charlotte,García-del Portillo Francisco,O’Byrne Conor,Johansson Jörgen (2022) 'Listeria monocytogenes Requires the RsbX Protein To Prevent SigB Activation under Nonstressed Conditions'. Journal of Bacteriology, 204 (1) [Details]
(2022) 'Perfluorooctanoic acid (PFOA) sensitises E. coli to acid stress'
Chugh, Gaurav and O’Byrne, Conor P and Abram, Florence (2022) 'Perfluorooctanoic acid (PFOA) sensitises E. coli to acid stress'. Access Microbiology, 4 (5) [DOI] [Details]
(2022) 'In Vitro Evolution of Listeria monocytogenes Reveals Selective Pressure for Loss of SigB and AgrA Function at Different Incubation Temperatures'
Guerreiro Duarte N.,Wu Jialun,McDermott Emma,Garmyn Dominique,Dockery Peter,Boyd Aoife,Piveteau Pascal,O’Byrne Conor P. (2022) 'In Vitro Evolution of Listeria monocytogenes Reveals Selective Pressure for Loss of SigB and AgrA Function at Different Incubation Temperatures'. Applied and Environmental Microbiology, 88 (11) [Details]
(2022) 'Molecular insights into intra-complex signal transmission during stressosome activation'
Miksys, Algirdas,Fu, Lifei,Madej, M. Gregor,Guerreiro, Duarte N.,Kaltwasser, Susann,Conway, Maria,Ejder, Sema,Bruckmann, Astrid,Marles-Wright, Jon,Lewis, Richard J.,O’Byrne, Conor,Pané-Farré, Jan,Ziegler, Christine (2022) 'Molecular insights into intra-complex signal transmission during stressosome activation'. Communications Biology, 5 (1) [Details]
(2022) 'Acid stress signals are integrated into the σB-dependent general stress response pathway via the stressosome in the food-borne pathogen Listeria monocytogenes'
Guerreiro, Duarte N. AND Pucciarelli, M. Graciela AND Tiensuu, Teresa AND Gudynaite, Diana AND Boyd, Aoife AND Johansson, Jörgen AND García-del Portillo, Francisco AND O’Byrne, Conor P. (2022) 'Acid stress signals are integrated into the σB-dependent general stress response pathway via the stressosome in the food-borne pathogen Listeria monocytogenes'. PLOS Pathogens, 18 (3):1-25 [DOI] [Details]
(2022) 'Phylogenetic and Phenotypic Analyses of a Collection of Food and Clinical Listeria monocytogenes Isolates Reveal Loss of Function of Sigma B from Several Clonal Complexes'
Wu Jialun,NicAogáin Kerrie,McAuliffe Olivia,Jordan Kieran,O’Byrne Conor (2022) 'Phylogenetic and Phenotypic Analyses of a Collection of Food and Clinical Listeria monocytogenes Isolates Reveal Loss of Function of Sigma B from Several Clonal Complexes'. Applied and Environmental Microbiology, 88 (10) [Details]
(2021) 'Activation of the Listeria monocytogenes stressosome in the intracellular eukaryotic environment'
Dessaux C;Pucciarelli MG;Guerreiro DN;O'Byrne CP;García-Del Portillo F; (2021) 'Activation of the Listeria monocytogenes stressosome in the intracellular eukaryotic environment'. Applied And Environmental Microbiology, [DOI] [Details]
(2021) 'Measurement of Protein Mobility in Listeria monocytogenes Reveals a Unique Tolerance to Osmotic Stress and Temperature Dependence of Diffusion'
Tran BM;Prabha H;Iyer A;O'Byrne C;Abee T;Poolman B; (2021) 'Measurement of Protein Mobility in Listeria monocytogenes Reveals a Unique Tolerance to Osmotic Stress and Temperature Dependence of Diffusion'. Frontiers In Microbiology, 12 [DOI] [Details]
(2021) 'Metagenomic identification, purification and characterisation of the Bifidobacterium adolescentis BgaC ß-galactosidase'
Mulualem, DM; Agbavwe, C; Ogilvie, LA; Jones, BV; Kilcoyne, M; O'Byrne, C; Boyd, A (2021) 'Metagenomic identification, purification and characterisation of the Bifidobacterium adolescentis BgaC ß-galactosidase'. Applied Microbiology And Biotechnology, 105 (3) [DOI] [Details]
(2020) 'Impact of osmotic stress on the phosphorylation and subcellular location of Listeria monocytogenes stressosome proteins'
Dessaux C;Guerreiro DN;Pucciarelli MG;O'Byrne CP;García-Del Portillo F; (2020) 'Impact of osmotic stress on the phosphorylation and subcellular location of Listeria monocytogenes stressosome proteins'. Scientific Reports, 10 (1) [DOI] [Details]
(2020) 'Amino acids other than glutamate affect the expression of the GAD system in Listeria monocytogenes enhancing acid resistance'
Paudyal, R;O'Byrne, CP;Karatzas, KA (2020) 'Amino acids other than glutamate affect the expression of the GAD system in Listeria monocytogenes enhancing acid resistance'. Food Microbiology, 90 [DOI] [Details]
(2020) 'Comparative Review of the Responses of Listeria monocytogenes and Escherichia coli to Low pH Stress'
Arcari T;Feger ML;Guerreiro DN;Wu J;O'Byrne CP; (2020) 'Comparative Review of the Responses of Listeria monocytogenes and Escherichia coli to Low pH Stress'. Genes, 11 (11) [DOI] [Details]
(2020) 'The SigB-mediated general stress response of Listeria monocytogenes: life and death decision making in a pathogen'
Guerreiro, Duarte N,Arcari, Talia,O'Byrne, Conor P (2020) 'The SigB-mediated general stress response of Listeria monocytogenes: life and death decision making in a pathogen'. Frontiers In Microbiology, 11 [Details]
(2020) 'Mild stress conditions during laboratory culture promote the proliferation of mutations that negatively affect Sigma B activity in Listeria monocytogenes'
Guerreiro DN; Wu J; Dessaux C; Oliveira AH; Tiensuu T; Gudynaite D; Marinho CM; Boyd A; García-Del Portillo F; Johansson J and O'Byrne CP (2020) 'Mild stress conditions during laboratory culture promote the proliferation of mutations that negatively affect Sigma B activity in Listeria monocytogenes'. Journal Of Bacteriology, [DOI] [Details]
(2019) 'Blue Light Sensing in Listeria monocytogenes Is Temperature-Dependent and the Transcriptional Response to It Is Predominantly SigB-Dependent'
Dorey, AL;Lee, BH;Rotter, B;O'Byrne, CP (2019) 'Blue Light Sensing in Listeria monocytogenes Is Temperature-Dependent and the Transcriptional Response to It Is Predominantly SigB-Dependent'. Frontiers In Microbiology, 10 [DOI] [Details]
(2010) 'The Vibrio parahaemolyticus Type III Secretion Systems manipulate host cell MAPK for critical steps in pathogenesis'
Matlawska-Wasowska, Ksenia and Finn, Rebecca and Mustel, Ana and O'Byrne, Conor P and Baird, Alan W and Coffey, Eleanor T and Boyd, Aoife (2010) 'The Vibrio parahaemolyticus Type III Secretion Systems manipulate host cell MAPK for critical steps in pathogenesis'. BMC microbiology, 10 [DOI] [Details]
(2020) 'Mild stress conditions during laboratory culture promote the proliferation of mutations that negatively affect sigma B activity in listeria monocytogenes'
Guerreiro, Duarte N. and Wu, Jialun and Dessaux, Charlotte and Oliveira, Ana H. and Tiensuu, Teresa and Gudynaite, Diana and Marinho, Catarina M. and Boyd, Aoife and del Portillo, Francisco García and Johansson, Jörgen and O'Byrne, Conor P. (2020) 'Mild stress conditions during laboratory culture promote the proliferation of mutations that negatively affect sigma B activity in listeria monocytogenes'. Journal of Bacteriology, 202 (9) [DOI] [Details]
(2023) 'In vivo characterisation of the Vibrio vulnificus stressosome: A complex involved in reshaping glucose metabolism and motility regulation, in nutrient- and iron-limited growth conditions'
Cutugno, Laura and Tamayo, Borja Khatabi Soliman and Lens, Piet N.L. and O'Byrne, Conor and Pané-Farré, Jan and Boyd, Aoife (2023) 'In vivo characterisation of the Vibrio vulnificus stressosome: A complex involved in reshaping glucose metabolism and motility regulation, in nutrient- and iron-limited growth conditions'. Current Research in Microbial Sciences, 4 [DOI] [Details]
(2023) 'Rifampicin-resistant RpoB S522L Vibrio vulnificus exhibits disturbed stress response and hypervirulence traits'
Cutugno, L, O'Byrne, C, Pane-Farre, J, Boyd, A. (2023) 'Rifampicin-resistant RpoB S522L Vibrio vulnificus exhibits disturbed stress response and hypervirulence traits'. Microbiologyopen, 12 (5) [DOI] [Details]
(2023) 'The Vibrio vulnificus stressosome is dispensable in nutrient-rich media'
Cutugno, L, Mc Cafferty, J, Pane-Farre, Jan, O'Byrne, C, Boyd, A. (2023) 'The Vibrio vulnificus stressosome is dispensable in nutrient-rich media'. Access Microbiology, 5 (7) [DOI] [Details]
(2020) 'Understanding How Microorganisms Respond to Acid pH Is Central to Their Control and Successful Exploitation'
Lund, PA;De Biase, D;Liran, O;Scheler, O;Mira, NP;Cetecioglu, Z;Fernandez, EN;Bover-Cid, S;Hall, R;Sauer, M;O'Byrne, C (2020) 'Understanding How Microorganisms Respond to Acid pH Is Central to Their Control and Successful Exploitation'. Frontiers In Microbiology, 11 [DOI] [Details]
(2020) 'rpoB mutations conferring rifampicin-resistance affect growth, stress response and motility in Vibrio vulnificus'
Cutugno L; Mc Cafferty J; Pané-Farré J; O'Byrne C and Boyd A (2020) 'rpoB mutations conferring rifampicin-resistance affect growth, stress response and motility in Vibrio vulnificus'. Microbiology, [DOI] [Details]
(2020) 'Genomic Differences between Listeria monocytogenes EGDe Isolates Reveal Crucial Roles for SigB and Wall Rhamnosylation in Biofilm Formation'
Hsu, CY;Cairns, L;Hobley, L;Abbott, J;O'Byrne, C;Stanley-Wall, NR (2020) 'Genomic Differences between Listeria monocytogenes EGDe Isolates Reveal Crucial Roles for SigB and Wall Rhamnosylation in Biofilm Formation'. Journal Of Bacteriology, 202 [DOI] [Details]
(2020) 'Genomic Differences between Listeria monocytogenes EGDe Isolates Reveal Crucial Roles for SigB and Wall Rhamnosylation in Biofilm Formation'
Hsu, CY,Cairns, L,Hobley, L,Abbott, J,O'Byrne, C,Stanley-Wall, NR (2020) 'Genomic Differences between Listeria monocytogenes EGDe Isolates Reveal Crucial Roles for SigB and Wall Rhamnosylation in Biofilm Formation'. Journal Of Bacteriology, 202 [DOI] [Details]
(2019) 'Role and regulation of the stress activated sigma factor sigma B (sigma(B)) in the saprophytic and host-associated life stages of Listeria monocytogenes'
Dorey, A;Marinho, C;Piveteau, P;O'Byrne, C (2019) 'Role and regulation of the stress activated sigma factor sigma B (sigma(B)) in the saprophytic and host-associated life stages of Listeria monocytogenes'. Advances In Applied Microbiology, Vol 65, 106 :1-48 [DOI] [Details]
(2019) 'Flick of a switch: regulatory mechanisms allowing Listeria monocytogenes to transition from a saprophyte to a killer'
Tiensuu T;Guerreiro DN;Oliveira AH;O'Byrne C;Johansson J; (2019) 'Flick of a switch: regulatory mechanisms allowing Listeria monocytogenes to transition from a saprophyte to a killer'. Microbiology, 165 (8) [DOI] [Details]
(2019) 'The sigma(B)-dependent regulatory sRNA Rli47 represses isoleucine biosynthesis in Listeria monocytogenes through a direct interaction with the ilvA transcript'
Marinho, CM;Dos Santos, PT;Kallipolitis, BH;Johansson, J;Ignatov, D;Guerreiro, DN;Piveteau, P;O'Byrne, CP (2019) 'The sigma(B)-dependent regulatory sRNA Rli47 represses isoleucine biosynthesis in Listeria monocytogenes through a direct interaction with the ilvA transcript'. Rna Biology, [DOI] [Details]
(2018) 'Absence of Curli in Soil-Persistent Escherichia coli Is Mediated by a C-di-GMP Signaling Defect and Suggests Evidence of Biofilm-Independent Niche Specialization'
Somorin, YM,Vollmerhausen, T,Waters, N,Pritchard, L,Abram, F,Brennan, F,O'Byrne, C (2018) 'Absence of Curli in Soil-Persistent Escherichia coli Is Mediated by a C-di-GMP Signaling Defect and Suggests Evidence of Biofilm-Independent Niche Specialization'. Frontiers In Microbiology, 9 [DOI] [Details]
(2017) 'Determination of Survival of Wildtype and Mutant Escherichia coli in Soil'
Somorin, Y,O'Byrne, C (2017) 'Determination of Survival of Wildtype and Mutant Escherichia coli in Soil'. Bio-Protocol, 7 [DOI] [Details]
(2017) 'A 3-year multi-food study of the presence and persistence of Listeria monocytogenes in 54 small food businesses in Ireland'
Leong, D,NicAogain, K,Luque-Sastre, L,McManamon, O,Hunt, K,Alvarez-Ordonez, A,Scollard, J,Schmalenberger, A,Fanning, S,O'Byrne, C,Jordan, K (2017) 'A 3-year multi-food study of the presence and persistence of Listeria monocytogenes in 54 small food businesses in Ireland'. International Journal Of Food Microbiology, 249 :18-26 [DOI] [Details]
(2017) 'Visible and UVA light as a potential means of preventing Escherichia coli biofilm formation in urine and on materials used in urethral catheters'
Vollmerhausen, TL; Conneely, AJ; Bennett, C; Wagner, VE; Victor, JC; O'Byrne C (2017) 'Visible and UVA light as a potential means of preventing Escherichia coli biofilm formation in urine and on materials used in urethral catheters'. J Photochem Photobiol B, 22 :295-303 [Details]
(2017) 'Roles for RpoS in survival of Escherichia coli during protozoan predation and in reduced moisture conditions highlight its importance in soil environments'
Somorin, Y,Bouchard, G,Gallagher, J,Abram, F,Brennan, F,O'Byrne, C (2017) 'Roles for RpoS in survival of Escherichia coli during protozoan predation and in reduced moisture conditions highlight its importance in soil environments'. Fems Microbiology Letters, 364 [DOI] [Details]
(2016) 'The Role of Stress and Stress Adaptations in Determining the Fate of the Bacterial Pathogen Listeria monocytogenes in the Food Chain'
Kerrie NicAogáin and Conor P. O’Byrne (2016) 'The Role of Stress and Stress Adaptations in Determining the Fate of the Bacterial Pathogen Listeria monocytogenes in the Food Chain'. Frontiers In Microbiology, 7 (article 1865) [DOI] [Details]
(2016) 'The presence of SigB in Listeria monocytogenes strains EGD-e and 10403S leads to hypersensitivity to hydrogen peroxide in stationary phase under aerobic conditions'
Boura M;Keating C;Royet K;Paudyal R;O'Donoghue B;O'Byrne CP;Karatzas KA; (2016) 'The presence of SigB in Listeria monocytogenes strains EGD-e and 10403S leads to hypersensitivity to hydrogen peroxide in stationary phase under aerobic conditions'. Applied And Environmental Microbiology, [DOI] [Details]
(2016) 'Blue-Light Inhibition of Listeria monocytogenes Growth Is Mediated by Reactive Oxygen Species and Is Influenced by sigma(B) and the Blue-Light Sensor Lmo0799'
O'Donoghue, B,NicAogain, K,Bennett, C,Conneely, A,Tiensuu, T,Johansson, J,O'Byrne, C (2016) 'Blue-Light Inhibition of Listeria monocytogenes Growth Is Mediated by Reactive Oxygen Species and Is Influenced by sigma(B) and the Blue-Light Sensor Lmo0799'. Applied And Environmental Microbiology, 82 :4017-4027 [DOI] [Details]
(2016) 'The general stress response is conserved in long-term soil-persistent strains of Escherichia coli'
Somorin Y;Abram F;Brennan F;O'Byrne C; (2016) 'The general stress response is conserved in long-term soil-persistent strains of Escherichia coli'. Applied And Environmental Microbiology, [DOI] [Details]
(2016) 'Inhibition of Listeria monocytogenes growth by blue light is mediated by reactive oxygen species: a role for sigma B and the blue light sensor, Lmo0799'
O'Donoghue B;NicAogáin K;Bennett C;Conneely A;Tiensuu T;Johansson J;O'Byrne C; (2016) 'Inhibition of Listeria monocytogenes growth by blue light is mediated by reactive oxygen species: a role for sigma B and the blue light sensor, Lmo0799'. Applied And Environmental Microbiology, [DOI] [Details]
(2013) 'Listeria monocytogenes has a functional gamma-aminobutyrate (GABA) shunt: Role in acid tolerance and succinate biosynthesis'
Feehily C, O'Byrne CP, Karatzas KA. (2013) 'Listeria monocytogenes has a functional gamma-aminobutyrate (GABA) shunt: Role in acid tolerance and succinate biosynthesis'. Applied And Environmental Microbiology, 79 (1):74-80 [ARAN Link] [Details]
(2012) 'Development and optimization of an EGFP-based reporter for measuring the general stress response in Listeria monocytogenes'
Utratna, M,Cosgrave, E,Baustian, C,Ceredig, R,O'Byrne, C (2012) 'Development and optimization of an EGFP-based reporter for measuring the general stress response in Listeria monocytogenes'. Bioengineered, 3 :93-103 [DOI] [Details]
(2012) 'Thiamine plays a critical role in the acid tolerance of Listeria monocytogenes'
Madeo M, O'Riordan N, Fuchs TM, Utratna M, Karatzas KA, O'Byrne CP. (2012) 'Thiamine plays a critical role in the acid tolerance of Listeria monocytogenes'. Fems Microbiology Letters, 326 (2):137-143 [Details]
(2011) 'Rapid, transient, and proportional activation of σB in response to osmotic stress in Listeria monocytogenes'
Utratna, M., Shaw, I., Starr, E., O'Byrne, C.P. (2011) 'Rapid, transient, and proportional activation of σB in response to osmotic stress in Listeria monocytogenes'. Applied and Environmental Microbiology, 77 (21):7841-7845 [Details]
(2011) 'Physiological and metabolic diversity in the yeast Kluyveromyces marxianus'
Lane, MM,Burke, N,Karreman, R,Wolfe, KH,O'Byrne, CP,Morrissey, JP (2011) 'Physiological and metabolic diversity in the yeast Kluyveromyces marxianus'. Antonie Van Leeuwenhoek International Journal Of General And Molecular Microbiology, 100 :507-519 [DOI] [Details]
(2011) 'A modified rapid enzymatic microtiter plate assay for the quantification of intracellular gamma-aminobutyric acid and succinate semialdehyde in bacterial cells'
O'Byrne, CP,Feehily, C,Ham, R,Karatzas, KAG (2011) 'A modified rapid enzymatic microtiter plate assay for the quantification of intracellular gamma-aminobutyric acid and succinate semialdehyde in bacterial cells'. Journal Of Microbiological Methods, 84 :137-139 [DOI] [Details]
(2010) 'Life in the gut: Microbial responses to stress in the gastrointestinal tract'
Louis P, and O'Byrne CP. (2010) 'Life in the gut: Microbial responses to stress in the gastrointestinal tract'. Science Progress, 93 :7-36 [Details]
(2010) 'The Vibrio parahaemolyticus Type III Secretion Systems manipulate host cell MAPK for critical steps in pathogenesis'
Matlawska-Wasowska, K; Finn, R; Mustel, A; O'Byrne, CP; Baird, AW; Coffey, ET and Boyd, A (2010) 'The Vibrio parahaemolyticus Type III Secretion Systems manipulate host cell MAPK for critical steps in pathogenesis'. BMC Microbiology, 10 [DOI] [Details]
(2010) 'Listeria monocytogenes: at the coalface of host-pathogen research'
O'Byrne CP and M. Utratna (2010) 'Listeria monocytogenes: at the coalface of host-pathogen research'. Bioengineered Bugs, 1 (6):1-7 [Details]
(2010) 'Intracellular Accumulation of High Levels of gamma-Aminobutyrate by Listeria monocytogenes 10403S in Response to Low pH: Uncoupling of gamma-Aminobutyrate Synthesis from Efflux in a Chemically Defined Medium'
Karatzas, KAG,Brennan, O,Heavin, S,Morrissey, J,O'Byrne, CP (2010) 'Intracellular Accumulation of High Levels of gamma-Aminobutyrate by Listeria monocytogenes 10403S in Response to Low pH: Uncoupling of gamma-Aminobutyrate Synthesis from Efflux in a Chemically Defined Medium'. Applied And Environmental Microbiology, 76 :3529-3537 [DOI] [Details]
(2009) 'Effect of weak acids on Listeria monocytogenes survival: Evidence for a viable but nonculturable state in response to low pH'
Cunningham, E,O'Byrne, C,Oliver, JD (2009) 'Effect of weak acids on Listeria monocytogenes survival: Evidence for a viable but nonculturable state in response to low pH'. Food Control, 20 :1141-1144 [DOI] [Details]
(2009) 'Inhibition of Listeria monocytogenes by acetate, benzoate and sorbate: weak acid tolerance is not influenced by the glutamate decarboxylase system'
Heavin, S.B., Brennan,O.M., Morrissey, J.P., and O'Byrne, CP. (2009) 'Inhibition of Listeria monocytogenes by acetate, benzoate and sorbate: weak acid tolerance is not influenced by the glutamate decarboxylase system'. Letters in Applied Microbiology, 49 :179-185 [Details]
(2008) 'The role of sigma B sigma B in the stress adaptations of Listeria monocytogenes: overlaps between stress adaptation and virulence'
O'Byrne CP, Karatzas KA. (2008) 'The role of sigma B sigma B in the stress adaptations of Listeria monocytogenes: overlaps between stress adaptation and virulence'. Advances In Applied Microbiology, Vol 45, 65 :115-140 [Details]
(2008) 'Identification of Components of the Sigma B Regulon in Listeria monocytogenes That Contribute to Acid and Salt Tolerance'
Abram, F; Starr, E; Karatzas, KAG; Matlawska-Wasowska, K; Boyd, A; Wiedmann, M; Boor, KJ; Connally, D and O'Byrne, CP (2008) 'Identification of Components of the Sigma B Regulon in Listeria monocytogenes That Contribute to Acid and Salt Tolerance'. Applied And Environmental Microbiology, 74 :6848-6858 [DOI] [ARAN Link] [Details]
(2008) 'Proteomic analyses of a Listeria monocytogenes mutant lacking sigma B identify new components of the sigmaB regulon and highlight a role for sigma B in the utilization of glycerol'
Abram F, Su WL, Wiedmann M, Boor KJ, Coote P, Botting C, Karatzas KA, O'Byrne CP. (2008) 'Proteomic analyses of a Listeria monocytogenes mutant lacking sigma B identify new components of the sigmaB regulon and highlight a role for sigma B in the utilization of glycerol'. Appl. Environ. Micro, 74 :594-604 [Details]
(2006) 'Global effects of homocysteine on transcription in Escherichia coli: induction of the gene for the major cold-shock protein'
Fraser KR, Tuite NL, Bhagwat A, O'Byrne C.P. (2006) 'Global effects of homocysteine on transcription in Escherichia coli: induction of the gene for the major cold-shock protein'. Microbiology, 152 (8):2221-2231 [Details]
(2005) 'Homocysteine toxicity in Escherichia coli is caused by a perturbation of branched-chain amino acid biosynthesis'
Tuite, NL,Fraser, KR,O'Byrne, CP (2005) 'Homocysteine toxicity in Escherichia coli is caused by a perturbation of branched-chain amino acid biosynthesis'. Journal Of Bacteriology, 187 :4362-4371 [DOI] [Details]
(2003) 'Weak organic acids: a panoply of effects on bacteria'
Hirshfield IN, Terzulli S, O'Byrne C. (2003) 'Weak organic acids: a panoply of effects on bacteria'. Sci Prog, 86 (4):245-269 [Details]
(2003) 'Enrichment of E. coli proteins by column chromatography on reactive dye columns'
Birch RM, O'Byrne C, Booth IR, Cash P. (2003) 'Enrichment of E. coli proteins by column chromatography on reactive dye columns'. Proteomics, 3 (5):764-776 [Details]
(2003) 'sB contributions to survival of lethal acidic conditions and to the acquired acid tolerance response are influenced by growth phase in Listeria monocytogenes'
Ferreira A, Sue D, O'Byrne CP, Boor KJ. (2003) 'sB contributions to survival of lethal acidic conditions and to the acquired acid tolerance response are influenced by growth phase in Listeria monocytogenes'. Appl Environ Microbiol, 69 (5):2692-2698 [Details]
(2003) 'The role of sigma B B in regulating the compatible solute uptake systems of Listeria monocytogenes: Osmotic induction of opuC is B-dependent'
Fraser KR, Sue D, Wiedmann M, Boor K, and O'Byrne CP. (2003) 'The role of sigma B B in regulating the compatible solute uptake systems of Listeria monocytogenes: Osmotic induction of opuC is B-dependent'. Appl Environ Microbiol, 69 (4):2015-2022 [Details]
(2002) 'Osmoprotection by carnitine in a Listeria monocytogenes mutant lacking the OpuC transporter: evidence for a low affinity carnitine uptake system'
Fraser, KR,O'Byrne, CP (2002) 'Osmoprotection by carnitine in a Listeria monocytogenes mutant lacking the OpuC transporter: evidence for a low affinity carnitine uptake system'. Fems Microbiology Letters, 211 :189-194 [DOI] [Details]
(2002) 'Sensing and adapting to acid stress'
Booth IR, Cash P, O'Byrne C. (2002) 'Sensing and adapting to acid stress'. Antonie Van Leeuwenhoek, 81 (01-Apr):33-42 [Details]
(2002) 'Inhibition of Escherichia coli growth by acetic acid: a problem with methionine biosynthesis and homocysteine toxicity'
Roe AJ, O'Byrne C, McLaggan D, Booth IR. (2002) 'Inhibition of Escherichia coli growth by acetic acid: a problem with methionine biosynthesis and homocysteine toxicity'. Microbiology, 148 (7):2215-2222 [Details]
(2002) 'Physiological analysis of the role of truB in Escherichia coli: a role for tRNA modification in extreme temperature resistance'
Kinghorn SM, O'Byrne CP, Booth IR, Stansfield I. (2002) 'Physiological analysis of the role of truB in Escherichia coli: a role for tRNA modification in extreme temperature resistance'. Microbiology, 148 (11):3511-3520 [Details]
(2002) 'Osmoregulation and its importance to food-borne microorganisms'
O'Byrne CP, Booth IR. (2002) 'Osmoregulation and its importance to food-borne microorganisms'. Int J Food Microbiol, 74 (3):203-216 [Details]
(2001) 'Role of sigma B in heat, ethanol, acid, and oxidative stress resistance and during carbon starvation in Listeria monocytogenes'
Ferreira A, O'Byrne CP, Boor KJ. (2001) 'Role of sigma B in heat, ethanol, acid, and oxidative stress resistance and during carbon starvation in Listeria monocytogenes'. Appl Environ Microbiol, 67 (10):4454-4457 [Details]
(2000) 'Molecular strategies for osmoregulation in the human food-borne pathogen Listeria monocytogenes'
O'Byrne CP, and Fraser KR. (2000) 'Molecular strategies for osmoregulation in the human food-borne pathogen Listeria monocytogenes'. Recent Research Developments in Microbiology, 4 :617-629 [Details]
(2000) 'Identification and characterization of an ATP binding cassette L-carnitine transporter in Listeria monocytogenes'
Fraser KR, Harvie D, Coote PJ, O'Byrne CP. (2000) 'Identification and characterization of an ATP binding cassette L-carnitine transporter in Listeria monocytogenes'. Appl Environ Microbiol, 66 (11):4696-4704 [Details]
(2000) 'Rapid inactivation of the Escherichia coli Kdp K+ uptake system by high potassium concentrations'
Roe AJ, McLaggan D, O'Byrne CP, Booth IR. (2000) 'Rapid inactivation of the Escherichia coli Kdp K+ uptake system by high potassium concentrations'. Mol Microbiol, 35 (5):1235-1243 [Details]
(1999) 'Survival of low-pH stress by Escherichia coli O157:H7: correlation between alterations in the cell envelope and increased acid tolerance'
Jordan KN, Oxford L, O'Byrne CP. (1999) 'Survival of low-pH stress by Escherichia coli O157:H7: correlation between alterations in the cell envelope and increased acid tolerance'. Appl Environ Microbiol, 65 (7):3048-3055 [Details]
(1998) 'Pathogenicity in isolates of Salmonella enterica serotype Enteritidis PT4 which differ in RpoS expression: effects of growth phase and low temperature'
Humphrey TJ, Williams A, McAlpine K, Jorgensen F, O'Byrne C. (1998) 'Pathogenicity in isolates of Salmonella enterica serotype Enteritidis PT4 which differ in RpoS expression: effects of growth phase and low temperature'. Epidemiol Infect, 121 (2):295-301 [Details]
(1998) 'Perturbation of anion balance during inhibition of growth of Escherichia coli by weak acids'
Roe AJ, McLaggan D, Davidson I, O'Byrne C, Booth IR. (1998) 'Perturbation of anion balance during inhibition of growth of Escherichia coli by weak acids'. J Bacteriol, 180 (4):767-772 [Details]
(1996) 'Acid tolerance in Listeria monocytogenes: the adaptive acid tolerance response ATR and growth-phase-dependent acid resistance'
Davis MJ, Coote PJ, O'Byrne CP. (1996) 'Acid tolerance in Listeria monocytogenes: the adaptive acid tolerance response ATR and growth-phase-dependent acid resistance'. Microbiology, 140 (10):2975-2982 [Details]
(1994) 'Transcription of the Salmonella typhimurium spv virulence locus is regulated negatively by the nucleoid-associated protein H-NS'
O'Byrne CP, Dorman CJ. (1994) 'Transcription of the Salmonella typhimurium spv virulence locus is regulated negatively by the nucleoid-associated protein H-NS'. FEMS Microbiol Lett, [Details]
(1994) 'The spv virulence operon of Salmonella typhimurium LT2 is regulated negatively by the cyclic AMP cAMP -cAMP receptor protein system'
O'Byrne CP, Dorman CJ. (1994) 'The spv virulence operon of Salmonella typhimurium LT2 is regulated negatively by the cyclic AMP cAMP -cAMP receptor protein system'. J Bacteriol, [Details]
(1992) 'The DNA supercoiling-sensitive expression of the Salmonella typhimurium his operon requires the his attenuator and is modulated by anaerobiosis and by osmolarity'
O'Byrne CP, Ni Bhriain N, Dorman CJ. (1992) 'The DNA supercoiling-sensitive expression of the Salmonella typhimurium his operon requires the his attenuator and is modulated by anaerobiosis and by osmolarity'. Mol Microbiol, 6 (17):2467-2476 [Details]

Book Chapters

  Year Publication
(2019) 'Role and regulation of the stress activated sigma factor sigma B (¿B) in the saprophytic and host-associated life stages of Listeria monocytogenes'
Dorey A;Marinho C;Piveteau P;O'Byrne C; (2019) 'Role and regulation of the stress activated sigma factor sigma B (¿B) in the saprophytic and host-associated life stages of Listeria monocytogenes' In: Advances in Applied Microbiology. Cambridge: Elsevier. [DOI] [Details]
(2017) 'Exploring the potential of light to prevent and treat microbial biofilms in medical and food applications'
Vollmerhausen, TL; Conneely, AJ; O'Byrne C (2017) 'Exploring the potential of light to prevent and treat microbial biofilms in medical and food applications' In: Antimicrobial Coatings and Modifications on Medical Devices. :215-240 Gewerbestrasse, Switzerland: Springer Nature. [Details]
(2012) 'Post-genomic insights into the regulation of transcription in the facultative intracelluar pathogen Listeria monocytogenes'
Heavin, S., & C.P. O’Byrne (2012) 'Post-genomic insights into the regulation of transcription in the facultative intracelluar pathogen Listeria monocytogenes' In: Stress Responses in Foodborne Microorganisms. USA: Wong, E. [Details]

Conference Publications

  Year Publication
(2016) International Congress on Applications of Lasers & Electro-Optics
Conneely, AJ; Bennett, C; O'Connor, GM; Vollmerhausen, TL; O'Byrne, C; Spence, G; Rowe, D; Victor, J (2016) Generation of side-emitting polymer optical fibres by laser ablation for use in antimicrobial applications International Congress on Applications of Lasers & Electro-Optics San Diego, CA USA, [Details]

Other Journals

  Year Publication
(2017) 'Determination of Survival of Wildtype and Mutant Escherichia coli in Soil'
Y. Somorin, C. P. O'Byrne (2017) 'Determination of Survival of Wildtype and Mutant Escherichia coli in Soil' Bio-protocol, 7 (14) . [DOI] [ARAN Link] [Details]

Conference Contributions

  Year Publication
(2016) ISOPOL,
Dorey, A. L., O'Donoghue, B., NicAogáin, K., O'Byrne, C. P. (2016) International Symposium on Problems of Listeria and Listeriosis. [Poster Presentation], ISOPOL, Paris, France , 14-JUN-16 - 17-JUN-16. [Details]
(2017) FEMS Microbiology Congress 2017,
Dorey, A. L., O'Donoghue, B., NicAogáin, K., O'Byrne, C. P. (2017) FEMS Microbiology Congress 2017. [Poster Presentation], FEMS Microbiology Congress 2017, Valencia, Spain , 09-JUL-17 - 13-JUL-17. [Details]
(2018) Microbial Stress: From Systems to Molecules and Back,
Dorey, A. L., O'Byrne, C. P. (2018) Microbial Stress: From Systems to Molecules and Back. [Poster Presentation], Microbial Stress: From Systems to Molecules and Back, Kinsale, Cork, Ireland , 23-APR-18 - 25-APR-18. [Details]
(2019) ISOPOL,
Dorey, A. L., Lee, B.H., Rotter, B., O'Byrne, C. P. (2019) International Symposium on Problems of Listeria and Listeriosis. [Poster Presentation], ISOPOL, Toronto, Canada , 30-SEP-19 - 03-OCT-19. [Details]

Conference Paper

  Year Publication
(2014) A functional RpoS-mediated stress response is retained in long-term soil-adapted Escherichia coli. Society for General Microbiology Annual Conference.
Somorin, Yinka,Brennan, Fiona P.,Abram, F.,O'Byrne, Conor (2014) A functional RpoS-mediated stress response is retained in long-term soil-adapted Escherichia coli. Society for General Microbiology Annual Conference. Liverpool: Conference Paper [Details]
(2010) Analysis of the signalling pathway involved in the IL-8 secretion response by eukaryotic intestinal epithelial cells after Vibrio parahaemolyticus infection. The Society for General Microbiology Irish Branch Meeting.
Mustel A, O’Byrne C, A Boyd. (2010) Analysis of the signalling pathway involved in the IL-8 secretion response by eukaryotic intestinal epithelial cells after Vibrio parahaemolyticus infection. The Society for General Microbiology Irish Branch Meeting. Conference Paper [Details]
(2009) Analysis of the signalling pathway involved in the IL-8 secretion response by eukaryotic intestinal epithelial cells after Vibrio parahaemolyticus infection. Vibrio 2009 - Third conference on the biology of Vibrios.
Mustel A, O’Byrne C, A Boyd. (2009) Analysis of the signalling pathway involved in the IL-8 secretion response by eukaryotic intestinal epithelial cells after Vibrio parahaemolyticus infection. Vibrio 2009 - Third conference on the biology of Vibrios. Conference Paper [Details]

Conference Poster

  Year Publication
(2013) Identification and characterisation of sugar binding adhesins of the human gut metagenome using bioformatics and functional metagenomics. Society for General Microbiology Spring Meeting.
Agbavwe, C; Louis, P; Boyd, A; Joshi, L; O’Byrne, C. (2013) Identification and characterisation of sugar binding adhesins of the human gut metagenome using bioformatics and functional metagenomics. Society for General Microbiology Spring Meeting. Conference Poster [Details]
(2013) Identification and characterisation of sugar binding adhesins of the human gut metagenome using bioformatics and functional metagenomics. Irish Division Society for General Microbiology Meeting.
Agbavwe, C; Louis, P; Boyd, A; Joshi, L; O’Byrne, C. (2013) Identification and characterisation of sugar binding adhesins of the human gut metagenome using bioformatics and functional metagenomics. Irish Division Society for General Microbiology Meeting. Conference Poster [Details]
(2012) Identification and characterization of novel glycan binding determinants in the human gut metagenome using bioinformatics and functional metagenomics. The Society for General Microbiology Annual Meeting 2012.
Agbavwe, C; Louis, P; Jones, B; Boyd, A; Joshi, L; O’Byrne, C (2012) Identification and characterization of novel glycan binding determinants in the human gut metagenome using bioinformatics and functional metagenomics. The Society for General Microbiology Annual Meeting 2012. Conference Poster [Details]

Reviews

  Year Publication
(2008) The Role of Sigma B (sigma(B)) in the Stress Adaptations of Listeria monocytogenes: Overlaps Between Stress Adaptation and Virulence.
O'Byrne, CP,Karatzas, KAG (2008) The Role of Sigma B (sigma(B)) in the Stress Adaptations of Listeria monocytogenes: Overlaps Between Stress Adaptation and Virulence. Reviews [DOI] [Details]

Workshops

  Year Publication
(2007) Coping with stress: the role of sigma B in modulating gene expression in the human pathogen Listeria monocytogenes. University College Dublin, School of Biomolecular and Biomedical Science.
O'Byrne, C. (2007) Coping with stress: the role of sigma B in modulating gene expression in the human pathogen Listeria monocytogenes. University College Dublin, School of Biomolecular and Biomedical Science. University College Dublin: Workshops [Details]
(2005) Escherichia coli as a model system for understanding heart disease in humans?. University of Edinburgh, Institute of Cell and Molecular Biology.
O'Byrne, C. (2005) Escherichia coli as a model system for understanding heart disease in humans?. University of Edinburgh, Institute of Cell and Molecular Biology. University of Edinburgh: Workshops [Details]
(2004) Understanding the basis for homocysteine toxicity in Escherichia coli. University College Cork, Department of Microbiology.
O'Byrne, C. (2004) Understanding the basis for homocysteine toxicity in Escherichia coli. University College Cork, Department of Microbiology. University College Cork: Workshops [Details]
(2002) Acetate stress in Escherichia coli: A problem with methionine biosynthesis and homocysteine toxicity. Microbial Stress Response Conference.
O'Byrne, C. (2002) Acetate stress in Escherichia coli: A problem with methionine biosynthesis and homocysteine toxicity. Microbial Stress Response Conference. Salve Regina University, Newport, RI, USA: Workshops [Details]
(2002) Exploring links between weak acid stress in Escherichia coli and heart disease in humans. Moyne Institute for Preventative Medicine, Trinity College Dublin.
O'Byrne, C. (2002) Exploring links between weak acid stress in Escherichia coli and heart disease in humans. Moyne Institute for Preventative Medicine, Trinity College Dublin. Trinity College Dublin: Workshops [Details]
(2002) From heart disease in humans to weak acid stress in E. Coli. NUI Galway, Department of Microbiology.
O'Byrne, C. (2002) From heart disease in humans to weak acid stress in E. Coli. NUI Galway, Department of Microbiology. Workshops [Details]