Medicine

Dr. Howard Oliver Fearnhead

PhD

Contact Details

Senior Lecturer
Biomedical Sciences Building
NUI, Galway
Upper Newcastle Road
Galway
T: 5115 / 5240
E: howard.fearnhead@nuigalway.ie

Biography

Dr Fearnhead completed a BSc. in Pharmacology and Toxicology at the London School of Pharmacy in 1991, before beginning a PhD. in apoptosis at the MRC-Toxicology Centre, Leicester, UK. In 1995 Dr Fearnhead began a post-doctoral fellowship at Cold Spring Harbor Laboratory, NY before becoming a principal investigator at the National Cancer Institute in Frederick, Maryland in 1999. In 2004 Dr Fearnhead moved to the National Centre of Biomedical Engineering Science, National University of Ireland, Galway and in 2006 was appointed a lecturer in the discipline of Pharmacology and Therapeutics.

Peer Reviewed Journals

	Year	Publication
	(2022)	'Establishing electroporation thresholds for targeted cell specific cardiac ablation in a 2D culture model' Avazzadeh, S; Dehkordi, MH; Owens, P; Jalali, A; O'Brien, B; Coffey, K; O'Halloran, M; Fearnhead, HO; Keane, D; Quinlan, LR. (2022) 'Establishing electroporation thresholds for targeted cell specific cardiac ablation in a 2D culture model'. Journal Of Cardiovascular Electrophysiology, [Details]
	(2020)	'Oxygenated Acyclic Diterpenes with Anticancer Activity from the Irish Brown Seaweed Bifurcaria bifurcata' Smyrniotopoulos, V; Merton, C; Firsova, S; Fearnhead, HO; Tasdemir, D (2020) 'Oxygenated Acyclic Diterpenes with Anticancer Activity from the Irish Brown Seaweed Bifurcaria bifurcata'. Marine Drugs, 18 (11) [Details]
	(2021)	'Density Functional Theory (DFT)-aided structure elucidation of linear diterpenes from the Irish brown seaweed Bifurcaria bifurcate' Smyrniotopoulos, V; Firsova, S; Fearnhead, HO; Grauso, L; Mangoni, A; Tasdemir, D (2021) 'Density Functional Theory (DFT)-aided structure elucidation of linear diterpenes from the Irish brown seaweed Bifurcaria bifurcate'. Marine Drugs, 19 (42) [DOI] [Details]
	(2021)	'Apoptosome formation through disruption of the K192-D616 salt bridge in the Apaf-1 closed form' Sahebazzamani, F; Hosseinkhani, S; Eriksson, LA; Fearnhead, HO (2021) 'Apoptosome formation through disruption of the K192-D616 salt bridge in the Apaf-1 closed form'. Acs Omega, 6 (35):22551-22558 [DOI] [Details]
	(2022)	'Non-cannonical Roles of Apoptotic Caspases in te Nervous System' Dehkordi, MH; Munn, RGK; Fearnhead, HO (2022) 'Non-cannonical Roles of Apoptotic Caspases in te Nervous System'. Frontiers In Cell And Developmental Biology, 10 [DOI] [Details]
	(2021)	'Loss of WD2 subdomain of Apaf-1 forms an apoptosome structure which blocks activation of caspase-3 and caspase-9' Noori AR, Tashakor A, Nikkhah M, Eriksson LA, Hosseinkhani S, Fearnhead HO. (2021) 'Loss of WD2 subdomain of Apaf-1 forms an apoptosome structure which blocks activation of caspase-3 and caspase-9'. Biochimie, 180 :23-29 [DOI] [Details]
	(2021)	'A robust platform for high-throughput screening of therapeutic strategies for acute and chronic spinal cord injury' Patil V;O'Connell E;Quinlan LR;Fearnhead H;McMahon S;Pandit A; (2021) 'A robust platform for high-throughput screening of therapeutic strategies for acute and chronic spinal cord injury'. Iscience, 24 (3) [DOI] [Details]
	(2020)	'The Lumiptosome, an engineered luminescent form of the apoptosome can report cell death by using the same Apaf-1 dependent pathway' Hosseini, ES;Nikkhah, M;Hamidieh, AA;Fearnhead, HO;Concordet, JP;Hosseinkhani, S (2020) 'The Lumiptosome, an engineered luminescent form of the apoptosome can report cell death by using the same Apaf-1 dependent pathway'. Journal Of Cell Science, 133 (10) [DOI] [Details]
	(2020)	'Apoptosome-dependent myotube formation involves activation of caspase-3 in differentiating myoblasts' H Dehkordi M;Tashakor A;O'Connell E;Fearnhead HO; (2020) 'Apoptosome-dependent myotube formation involves activation of caspase-3 in differentiating myoblasts'. Cell Death And Disease, 11 (5) [DOI] [Details]
	(2020)	'A Novel High-Throughput Screening Platform Identifies Itaconate Derivatives from Marine Penicillium antarcticum as Inhibitors of Mesenchymal Stem Cell Differentiation' Marchese, P; Mahajan, N; O'Connell, E; Fearnhead, H; Tuohy, M; Krawczyk, J; Thomas, OP; Barry, F; Murphy, MJ (2020) 'A Novel High-Throughput Screening Platform Identifies Itaconate Derivatives from Marine Penicillium antarcticum as Inhibitors of Mesenchymal Stem Cell Differentiation'. Marine Drugs, 18 (192) [DOI] [ARAN Link] [Details]
	(2019)	'Droplet Combinations: A Scalable Microfluidic Platform for Biochemical Assays' Cliffe, FE;Lyons, M;Murphy, DC;McInerney, L;Hurley, N;Galvin, MA;Mulqueen, J;Bible, LB;Marella, C;Kelleher, M;O'Sullivan, A;Fearnhead, HO;O'Connell, E;Davies, M (2019) 'Droplet Combinations: A Scalable Microfluidic Platform for Biochemical Assays'. Slas Technology, 25 (2):140-150 [DOI] [Details]
	(2019)	'A new split-luciferase complementation assay identifies pentachlorophenol as an inhibitor of apoptosome formation' Tashakor A;H-Dehkordi M;O'Connell E;Gomez Ganau S;Gozalbes R;Eriksson LA;Hosseinkhani S;Fearnhead HO; (2019) 'A new split-luciferase complementation assay identifies pentachlorophenol as an inhibitor of apoptosome formation'. FEBS open bio, 9 (7):1194-1203 [DOI] [Details]
	(2017)	'Viral hijacking of host caspases: an emerging category of pathogen-host interactions' Connolly PF, Fearnhead HO. (2017) 'Viral hijacking of host caspases: an emerging category of pathogen-host interactions'. Cell Death And Differentiation, 24 (8):1401-1410 [Details]
	(2016)	'DNA-PK activity is associated with caspase-dependent myogenic differentiation' Connolly, PF,Fearnhead, HO (2016) 'DNA-PK activity is associated with caspase-dependent myogenic differentiation'. Febs Journal, 283 :3626-3636 [DOI] [Details]
	(2016)	'Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)' Klionsky DJ;Abdelmohsen K;Abe A;Abedin MJ;Abeliovich H;Acevedo Arozena A;Adachi H;Adams CM;Adams PD;Adeli K;Adhihetty PJ;Adler SG;Agam G;Agarwal R;Aghi MK;Agnello M;Agostinis P;Aguilar PV;Aguirre-Ghiso J;Airoldi EM;Ait-Si-Ali S;Akematsu T;Akporiaye ET;Al-Rubeai M;Albaiceta GM;Albanese C;Albani D;Albert ML;Aldudo J;Algül H;Alirezaei M;Alloza I;Almasan A;Almonte-Beceril M;Alnemri ES;Alonso C;Altan-Bonnet N;Altieri DC;Alvarez S;Alvarez-Erviti L;Alves S;Amadoro G;Amano A;Amantini C;Ambrosio S;Amelio I;Amer AO;Amessou M;Amon A;An Z;Anania FA;Andersen SU;Andley UP;Andreadi CK;Andrieu-Abadie N;Anel A;Ann DK;Anoopkumar-Dukie S;Antonioli M;Aoki H;Apostolova N;Aquila S;Aquilano K;Araki K;Arama E;Aranda A;Araya J;Arcaro A;Arias E;Arimoto H;Ariosa AR;Armstrong JL;Arnould T;Arsov I;Asanuma K;Askanas V;Asselin E;Atarashi R;Atherton SS;Atkin JD;Attardi LD;Auberger P;Auburger G;Aurelian L;Autelli R;Avagliano L;Avantaggiati ML;Avrahami L;Awale S;Azad N;Bachetti T;Backer JM;Bae DH;Bae JS;Bae ON;Bae SH;Baehrecke EH;Baek SH;Baghdiguian S;Bagniewska-Zadworna A;Bai H;Bai J;Bai XY;Bailly Y;Balaji KN;Balduini W;Ballabio A;Balzan R;Banerjee R;Bánhegyi G;Bao H;Barbeau B;Barrachina MD;Barreiro E;Bartel B;Bartolomé A;Bassham DC;Bassi MT;Bast RC;Basu A;Batista MT;Batoko H;Battino M;Bauckman K;Baumgarner BL;Bayer KU;Beale R;Beaulieu JF;Beck GR;Becker C;Beckham JD;Bédard PA;Bednarski PJ;Begley TJ;Behl C;Behrends C;Behrens GM;Behrns KE;Bejarano E;Belaid A;Belleudi F;Bénard G;Berchem G;Bergamaschi D;Bergami M;Berkhout B;Berliocchi L;Bernard A;Bernard M;Bernassola F;Bertolotti A;Bess AS;Besteiro S;Bettuzzi S;Bhalla S;Bhattacharyya S;Bhutia SK;Biagosch C;Bianchi MW;Biard-Piechaczyk M;Billes V;Bincoletto C;Bingol B;Bird SW;Bitoun M;Bjedov I;Blackstone C;Blanc L;Blanco GA;Blomhoff HK;Boada-Romero E;Böckler S;Boes M;Boesze-Battaglia K;Boise LH;Bolino A;Boman A;Bonaldo P;Bordi M;Bosch J;Botana LM;Botti J;Bou G;Bouché M;Bouchecareilh M;Boucher MJ;Boulton ME;Bouret SG;Boya P;Boyer-Guittaut M;Bozhkov PV;Brady N;Braga VM;Brancolini C;Braus GH;Bravo-San Pedro JM;Brennan LA;Bresnick EH;Brest P;Bridges D;Bringer MA;Brini M;Brito GC;Brodin B;Brookes PS;Brown EJ;Brown K;Broxmeyer HE;Bruhat A;Brum PC;Brumell JH;Brunetti-Pierri N;Bryson-Richardson RJ;Buch S;Buchan AM;Budak H;Bulavin DV;Bultman SJ;Bultynck G;Bumbasirevic V;Burelle Y;Burke RE;Burmeister M;Bütikofer P;Caberlotto L;Cadwell K;Cahova M;Cai D;Cai J;Cai Q;Calatayud S;Camougrand N;Campanella M;Campbell GR;Campbell M;Campello S;Candau R;Caniggia I;Cantoni L;Cao L;Caplan AB;Caraglia M;Cardinali C;Cardoso SM;Carew JS;Carleton LA;Carlin CR;Carloni S;Carlsson SR;Carmona-Gutierrez D;Carneiro LA;Carnevali O;Carra S;Carrier A;Carroll B;Casas C;Casas J;Cassinelli G;Castets P;Castro-Obregon S;Cavallini G;Ceccherini I;Cecconi F;Cederbaum AI;Ceña V;Cenci S;Cerella C;Cervia D;Cetrullo S;Chaachouay H;Chae HJ;Chagin AS;Chai CY;Chakrabarti G;Chamilos G;Chan EY;Chan MT;Chandra D;Chandra P;Chang CP;Chang RC;Chang TY;Chatham JC;Chatterjee S;Chauhan S;Che Y;Cheetham ME;Cheluvappa R;Chen CJ;Chen G;Chen GC;Chen G;Chen H;Chen JW;Chen JK;Chen M;Chen M;Chen P;Chen Q;Chen Q;Chen SD;Chen S;Chen SS;Chen W;Chen WJ;Chen WQ;Chen W;Chen X;Chen YH;Chen YG;Chen Y;Chen Y;Chen Y;Chen YJ;Chen YQ;Chen Y;Chen Z;Chen Z;Cheng A;Cheng CH;Cheng H;Cheong H;Cherry S;Chesney J;Cheung CH;Chevet E;Chi HC;Chi SG;Chiacchiera F;Chiang HL;Chiarelli R;Chiariello M;Chieppa M;Chin LS;Chiong M;Chiu GN;Cho DH;Cho SG;Cho WC;Cho YY;Cho YS;Choi AM;Choi EJ;Choi EK;Choi J;Choi ME;Choi SI;Chou TF;Chouaib S;Choubey D;Choubey V;Chow KC;Chowdhury K;Chu CT;Chuang TH;Chun T;Chung H;Chung T;Chung YL;Chwae YJ;Cianfanelli V;Ciarcia R;Ciechomska IA;Ciriolo MR;Cirone M;Claerhout S;Clague MJ;Clària J;Clarke PG;Clarke R;Clementi E;Cleyrat C;Cnop M;Coccia EM;Cocco T;Codogno P;Coers J;Cohen EE;Colecchia D;Coletto L;Coll NS;Colucci-Guyon E;Comincini S;Condello M;Cook KL;Coombs GH;Cooper CD;Cooper JM;Coppens I;Corasaniti MT;Corazzari M;Corbalan R;Corcelle-Termeau E;Cordero MD;Corral-Ramos C;Cort (2016) 'Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)'. Autophagy, 12 (1):1-222 [DOI] [Details]
	(2014)	'Selective repression of the oncogene cyclin D1 by the tumor suppressor miR-206 in cancers' Elliman, SJ,Howley, BV,Mehta, DS,Fearnhead, HO,Kemp, DM,Barkley, LR (2014) 'Selective repression of the oncogene cyclin D1 by the tumor suppressor miR-206 in cancers'. Oncogenesis, 3 [DOI] [Details]
	(2014)	'Inhibition of protein synthesis and JNK activation are not required for cell death induced by anisomycin and anisomycin analogues' Monaghan, D,O'Connell, E,Cruickshank, FL,O'Sullivan, B,Giles, FJ,Hulme, AN,Fearnhead, HO (2014) 'Inhibition of protein synthesis and JNK activation are not required for cell death induced by anisomycin and anisomycin analogues'. Biochemical And Biophysical Research Communications, 443 :761-767 [DOI] [Details]
	(2014)	'New roles for old enzymes: killer caspases as the engine of cell behavior changes' Connolly, PF,Jager, R,Fearnhead, HO (2014) 'New roles for old enzymes: killer caspases as the engine of cell behavior changes'. Frontiers in physiology, 5 (149) [DOI] [Details]
	(2014)	'Mesenchymal stem cells and a vitamin D receptor agonist additively suppress T helper 17 cells and the related inflammatory response in the kidney' Duffy MM;McNicholas BA;Monaghan DA;Hanley SA;McMahon JM;Pindjakova J;Alagesan S;Fearnhead HO;Griffin MD; (2014) 'Mesenchymal stem cells and a vitamin D receptor agonist additively suppress T helper 17 cells and the related inflammatory response in the kidney'. American Journal Of Physiology-Renal Physiology, 307 (12):F1412-F1426 [DOI] [Details]
	(2012)	'Dead Cells Talking: The Silent Form of Cell Death Is Not so Quiet' Jaeger R, Fearnhead HO (2012) 'Dead Cells Talking: The Silent Form of Cell Death Is Not so Quiet'. Biochem, 2012 :1-8 [DOI] [Details]
	(2011)	'Autophagosomal I kappa B alpha Degradation Plays a Role in the Long Term Control of Tumor Necrosis Factor-alpha-induced Nuclear Factor-kappa B (NF-kappa B) Activity' Colleran, A,Ryan, A,O'Gorman, A,Mureau, C,Liptrot, C,Dockery, P,Fearnhead, H,Egan, LJ (2011) 'Autophagosomal I kappa B alpha Degradation Plays a Role in the Long Term Control of Tumor Necrosis Factor-alpha-induced Nuclear Factor-kappa B (NF-kappa B) Activity'. Journal Of Biological Chemistry, 286 :22886-22893 [DOI] [Details]
	(2010)	'p53-mediated induction of Noxa and p53AIP1 requires NFkappaB' O'Prey J, Crighton D, Martin AG, Vousden KH, Fearnhead HO, Ryan KM (2010) 'p53-mediated induction of Noxa and p53AIP1 requires NFkappaB'. Cell Cycle, 9 (5):947-952 [Details]
	(2010)	'TPCK targets elements of mitotic spindle and induces cell cycle arrest in prometaphase' Fabian, Z,Fearnhead, HO (2010) 'TPCK targets elements of mitotic spindle and induces cell cycle arrest in prometaphase'. Biochemical And Biophysical Research Communications, 395 :458-464 [DOI] [Details]
	(2009)	'TPCK-induced apoptosis and labelling of the largest subunit of RNA polymerase II in Jurkat cells' Fabian, Z,O'Brien, P,Pajecka, K,Fearnhead, HO (2009) 'TPCK-induced apoptosis and labelling of the largest subunit of RNA polymerase II in Jurkat cells'. Apoptosis, 14 :1154-1164 [DOI] [Details]
	(2009)	'Activation of p73 and induction of Noxa by DNA damage requires NF-kappa B' Martin, A. G.,Trama, J.,Crighton, D.,Ryan, K. M.,Fearnhead, H. O. (2009) 'Activation of p73 and induction of Noxa by DNA damage requires NF-kappa B'. Aging, 1 (33):335-49 [Details]
	(2009)	*'The Apaf-1procaspase-9 apoptosome complex functions as a proteolytic-based molecular timer'** Malladi S, Challa-Malladi M, Fearnhead HO, Bratton SB (2009) 'The Apaf-1procaspase-9 apoptosome complex functions as a proteolytic-based molecular timer'. Embo Journal*, 28 (13):1916-1925 [DOI] [Details]
	(2008)	'A non-apoptotic role for caspase-9 in muscle differentiation' Murray TV, McMahon JM, Howley BA, Stanley A, Ritter T, Mohr A, Zwacka R, Fearnhead HO (2008) 'A non-apoptotic role for caspase-9 in muscle differentiation'. Journal Of Cell Science, 121 (Pt 22):3786-3793 [DOI] [Details]
	(2008)	'Caspases as therapeutic targets' Howley B, Fearnhead HO (2008) 'Caspases as therapeutic targets'. Journal Of Cellular And Molecular Medicine, 12 (5A):1502-1516 [DOI] [Details]
	(2007)	'Identification of an inhibitor of caspase activation from heart extracts; ATP blocks apoptosome formation' Samali, A,O'Mahoney, M,Reeve, J,Logue, S,Szegezdi, E,McMahon, J,Fearnhead, HO (2007) 'Identification of an inhibitor of caspase activation from heart extracts; ATP blocks apoptosome formation'. Apoptosis, 12 :465-474 [DOI] [Details]
	(2006)	'Small molecule inhibitors of Apaf-1-related caspase- 3/-9 activation that control mitochondrial-dependent apoptosis' Malet G, MartÃn AG, OrzÃ¡ez M, Vicent MJ, Masip I, Sanclimens G, Ferrer-Montiel A, Mingarro I, Messeguer A, Fearnhead HO, PÃ©rez-PayÃ¡ E (2006) 'Small molecule inhibitors of Apaf-1-related caspase- 3/-9 activation that control mitochondrial-dependent apoptosis'. Cell Death And Differentiation, 13 (9):1523-1532 [DOI] [Details]
	(2006)	'Intracellular Nucleotides Act as Critical Prosurvival Factors by Binding to Cytochrome C and Inhibiting Apoptosome' Chandra, D., Bratton, S. B., Person, M. D., Tian, Y., Martin, A. G., Ayres, M., Fearnhead, H. O., Gandhi, V. and Tang, D. G. (2006) 'Intracellular Nucleotides Act as Critical Prosurvival Factors by Binding to Cytochrome C and Inhibiting Apoptosome'. Cell, 125 :1333-1346 [Details]
	(2006)	'Does ATP promote or protect cells from apoptosis?' Chandra, D., Ayres, M., Gandhi, V., Bratton, S.B., Person, M.D., Tian, Y., Martin, A.G., Fearnhead, H.O. (2006) 'Does ATP promote or protect cells from apoptosis?'. Cancer Biology & Therapy, 5 (7) [Details]
	(2004)	'Apo cytochrome c inhibits caspases by preventing apoptosome formation' Martin AG, Nguyen J, Wells JA, Fearnhead HO (2004) 'Apo cytochrome c inhibits caspases by preventing apoptosome formation'. Biochem, 319 (3):944-950 [DOI] [Details]
	(2004)	'Getting Back on Track, or What to Do When Apoptosis Is De-Railed: Recoupling Oncogenes to the Apoptotic Machinery' Fearnhead, H. O. (2004) 'Getting Back on Track, or What to Do When Apoptosis Is De-Railed: Recoupling Oncogenes to the Apoptotic Machinery'. Cancer Biology & Therapy, 3 (1):21-28 [Details]
	(2004)	'Assay for ubiquitin ligase activity: high-throughput screen for inhibitors of HDM2' Davydov, I. V.,Woods, D.,Safiran, Y. J.,Oberoi, P.,Fearnhead, H. O.,Fang, S.,Jensen, J. P.,Weissman, A. M.,Kenten, J. H.,Vousden, K. H. (2004) 'Assay for ubiquitin ligase activity: high-throughput screen for inhibitors of HDM2'. J Biomol Screen, 9 (88):695-703 [Details]
	(2002)	'Apocytochrome c blocks caspase-9 activation and Bax-induced apoptosis' Martin AG, Fearnhead HO (2002) 'Apocytochrome c blocks caspase-9 activation and Bax-induced apoptosis'. Journal Of Biological Chemistry, 277 (52):50834-50841 [DOI] [Details]
	(2001)	'Cell-free systems to study apoptosis' Fearnhead, H. O. (2001) 'Cell-free systems to study apoptosis'. Methods in Cell Biology, 66 :167-185 [Details]
	(2001)	'Molecular cloning of ILP-2, a novel member of the inhibitor of apoptosis protein family' Richter BW, Mir SS, Eiben LJ, Lewis J, Reffey SB, Frattini A, Tian L, Frank S, Youle RJ, Nelson DL, Notarangelo LD, Vezzoni P, Fearnhead HO, Duckett CS (2001) 'Molecular cloning of ILP-2, a novel member of the inhibitor of apoptosis protein family'. Molecular And Cellular Biology, 21 (13):4292-4301 [DOI] [Details]
	(1998)	'Oncogene-dependent caspase activation is mediated by caspase-9' Fearnhead, H. O., Rodriguez, J., Govek, E., Guo, W., Kobayashi, R., Hannon, G. and Lazebnik, Y. A. (1998) 'Oncogene-dependent caspase activation is mediated by caspase-9'. Proceedings of the National Academy of Sciences, 95 :13664-13669 [Details]
	(1997)	'Oncogene-dependent apoptosis in extracts from drug-resistant cells' Fearnhead, H. O., McCurrach, M. E., O'Neill, J., Zhang, K., Lowe, S. W. and Lazebnik, Y. A. (1997) 'Oncogene-dependent apoptosis in extracts from drug-resistant cells'. Genes and Development, 11 :1266-1276 [Details]
	(1997)	'Multiple species of CPP32 and Mch2 are the major active caspases present in apoptotic cells' Faleiro, L.,Kobayashi, R.,Fearnhead, H.,Lazebnik, Y. (1997) 'Multiple species of CPP32 and Mch2 are the major active caspases present in apoptotic cells'. EMBO J, 16 (99):2271-81 [Details]
	(1995)	'DNA degradation and proteolysis in thymocyte apoptosis' Fearnhead HO, MacFarlane M, Dinsdale D, Cohen GM (1995) 'DNA degradation and proteolysis in thymocyte apoptosis'. Toxicology letters, 82-83 :135-141 [Details]
	(1995)	'A pre-existing protease is a common effector of thymocyte apoptosis mediated by diverse stimuli' Fearnhead, H. O.,Rivett, A. J.,Dinsdale, D.,Cohen, G. M. (1995) 'A pre-existing protease is a common effector of thymocyte apoptosis mediated by diverse stimuli'. FEBS Lett, 357 (33):242-6 [Details]
	(1995)	'An ICE-like protease is a common mediator of apoptosis induced by diverse stimuli in human monocytic THP.1 cells' Zhu, H.,Fearnhead, H. O.,Cohen, G. M. (1995) 'An ICE-like protease is a common mediator of apoptosis induced by diverse stimuli in human monocytic THP.1 cells'. FEBS Lett, 374 (22):303-8 [Details]
	(1995)	'An interleukin-1 beta-converting enzyme-like protease is a common mediator of apoptosis in thymocytes' Fearnhead HO, Dinsdale D, Cohen GM (1995) 'An interleukin-1 beta-converting enzyme-like protease is a common mediator of apoptosis in thymocytes'. Febs Letters, 375 (3):283-288 [Details]
	(1994)	'Formation of large molecular weight fragments of DNA is a key committed step of apoptosis in thymocytes' Cohen G. M., X.M.Sun, X. M., Fearnhead, H. O., MacFarlane, M., Brown, D. G., Snowden, R. T. & Dinsdale, D. (1994) 'Formation of large molecular weight fragments of DNA is a key committed step of apoptosis in thymocytes'. Journal of Immunology, 153 :507-516 [Details]
	(1994)	'Dexamethasone and etoposide induce apoptosis in rat thymocytes from different phases of the cell cycle' Fearnhead, H. O., Chwalinski, M., Snowden, R. T., Ormerod, M. G. & Cohen, G. M. (1994) 'Dexamethasone and etoposide induce apoptosis in rat thymocytes from different phases of the cell cycle'. Biochemical Pharmacology, 48 :1073-1079 [Details]
	(1994)	'Cdc2 activation is not required for thymocyte apoptosis' Norbury, C.,MacFarlane, M.,Fearnhead, H.,Cohen, G. M. (1994) 'Cdc2 activation is not required for thymocyte apoptosis'. Biochem Biophys Res Commun, 202 (33):1400-6 [Details]
	(1993)	'Increased membrane permeability of apoptotic thymocytes: a flow cytometric study' Ormerod, M. G., Sun, X. M., Snowden, R. T., Davies, R., Fearnhead, H. O. & Cohen, G. M. (1993) 'Increased membrane permeability of apoptotic thymocytes: a flow cytometric study'. Cytometry, 14 :595-602 [Details]

Book Chapters

	Year	Publication
	(1995)	'Mechanisms of Cell Death, with Particular Reference to Apoptosis' Cohen, GM; MacFarlane, M; Fearnehad, HO; Sun, XM,; Dinsdale, D. (1995) 'Mechanisms of Cell Death, with Particular Reference to Apoptosis' In: Molecular and Cellular Mechanisms of Toxicity. :185-203 UK: CRC Press. [Details]
	(2013)	'Mitochondrial Regulation of Cell Death' Richard Jaeger and Howard O. Fearnhead (2013) 'Mitochondrial Regulation of Cell Death' In: Mitochondria as Targets for Phytochemicals in Cancer Prevention and Therapy. USA: Springer. [Details]

Conference Publications

	Year	Publication
	(2003)	*Apoptosis 2003 : from signaling pathways to therapeutic tools* Martin, A; Martin, N; Fearnhead, H. (2003) 'Apocytochrome c blocks caspase-9 activation and Bax-induced apoptosis Apoptosis 2003 : from signaling pathways to therapeutic tools [Details]
	(2003)	*Apoptosis 2003 : from signaling pathways to therapeutic tools* Martin, A; Martin, N; Fearnhead, H. (2003) 'Activation of p73 and induction of Noxa by DNA damage requires NF-kappa B Apoptosis 2003 : from signaling pathways to therapeutic tools [Details]
	(2017)	*25th Euroconference on Apoptosis* Tashakor, A; Dehkordi, M; O'Connell, E; Hosseinkhani, S;Fearnhead, H. (2017) Identifying Apaf-1 inhibitors using a new split luciferase assay 25th Euroconference on Apoptosis [Details]
	(2001)	*Molecular Biology of the Cell* Fearnhead, H. (2001) Oncogene-dependent caspase activation Molecular Biology of the Cell Washington DC, , pp.135A-135A [Details]
	(1997)	*Biology of Proteolysis* Fearnhead, H; McCurrach, M; Lowe, S; Lazebnik, Y. (1997) Caspase activation in extracts from drug-resistant cells Biology of Proteolysis [Details]
	(2014)	*Planta Medica* Smyrniotopoulos, V; Firsova, D; Rae, M; Heesch, S; Fearnhead, H; Tasdemir, (2014) Linear diterpenes with anticancer activity from the irish brown alga Bifurcaria bifurcata Planta Medica [Details]
	(2018)	*XI European Conference on Marine Natural Products Portugal* Marchese, P; Young, R; O¿Connell, E; Baker, B; Johnson, M; Fearnhead, H; Allcock, L; Murphy, M. (2018) Preliminary evidence of bioactivity from deep sea coral and sponge extracts: influencing human stem cell growth and differentiation XI European Conference on Marine Natural Products Portugal [Details]

Other Journals

	Year	Publication
	(2017)	'The reliability of assay-ready plates for cell-based screening enabled by the Echo® 550 Liquid Handler' Gul, S; Wolf M; O'Connell, E; Fearnhead, H. (2017) 'The reliability of assay-ready plates for cell-based screening enabled by the Echo® 550 Liquid Handler' Drug Target Review, . [Details]
	(2017)	'Using clinical drug resistance to kill cancer cells' Gul, S; Fearnhead, H. (2017) 'Using clinical drug resistance to kill cancer cells' Drug Target Review, 2 (22) :12-14. [Details]

Conference Contributions

	Year	Publication
	(2017)	In vitro Toxicology Society 2017, F. Steinmetz, M. Clift, R. Broughton, P. Jone, P. Fowler, D. Kidd (2017) Annual meeting. [Conference Organising Committee Member], In vitro Toxicology Society 2017, Senate House London, , 23-NOV-17 - 24-NOV-17. [Details]
	(2015)	NUI Galway Cancer Awareness Day, G. McCormack, H. Fearnhead (2015) Outreach on Cancer Research at NUIG. [Conference Organising Committee Member], NUI Galway Cancer Awareness Day, NUI Galway , 02-FEB-15. [Details]
	(2014)	European Molecular Biology Organization workshop on Micro RNA, H. Fearnhead (2014) 7 day practical workshop. [Conference Organising Committee Chairperson], European Molecular Biology Organization workshop on Micro RNA, NUI Galway , 12-MAY-14. [Details]
	(2012)	European Molecular Biology Organization workshop on Micro RNA, H. Fearnhead (2012) 7 day practical workshop. [Conference Organising Committee Chairperson], European Molecular Biology Organization workshop on Micro RNA, NUI Galway , 10-APR-12. [Details]
	(2016)	In vitro Toxicology Society, H. Fearnhead (2016) Cell Death in Toxicology. [Keynote Address], In vitro Toxicology Society, Glasgow , 11-NOV-16. [Details]
	(2016)	Seminar Series, H. Fearnhead (2016) Non apoptotic roles of caspases. [Invited Lecture], Seminar Series, University of Applied Sciences, Rheinbach Germany , 14-APR-16. [Details]
	(2015)	14th annual workshop of Cell Biology of Viral Infection, H. Fearnhead (2015) Non apoptotic roles of caspases. [Keynote Address], 14th annual workshop of Cell Biology of Viral Infection, Schoental, Germany , 11-SEP-15. [Details]
	(2016)	International Cell Death Society, Connolly, Fearnhead. (2016) DNA-PK is required for myoblast differentiation. [Oral Presentation], International Cell Death Society, Cork, Ireland , 02-JUN-16 - 04-JUN-16. [Details]
	(2014)	Non-coding RNA: From in-situ hybridization to next generation sequencing, Howard Fearnhead, Vladimir Benes, Donal O'Carroll (2014) EMBL-sponsored training course for international scientists. [Conference Organising Committee Chairperson], Non-coding RNA: From in-situ hybridization to next generation sequencing, NUI Galway , 06-JUN-14 - 13-JUN-14. [Details]
	(2013)	Mechanisms of Cell Death - The command to die, Howard Fearnhead (2013) International Cell Death Society Meeting. [Invited Lecture], Mechanisms of Cell Death - The command to die, Spain , 01-JUN-13 - 06-JUN-13. [Details]
	(2011)	From in-situ hybridization to next-generation sequencing, Howard Fearnhead, Vladimir Benes, Donal O'Carroll (2011) EMBL-sponsored training course for international scientists. [Conference Organising Committee Chairperson], From in-situ hybridization to next-generation sequencing, NUI Galway , 21-MAY-11 - 27-MAY-11. [Details]
	(2010)	MicroRNA profiling: From In-Situ Hybridization to New Gen Sequencing, Howard Fearnhead (2010) MicroRNAs (miRNA) are short, noncoding regulatory RNAs involved in development, differentiation, and metabolism of most eukaryotic organisms. Investigating miRNA expression in these cellular processes is important for our understanding of fundamental biological processes and many different diseases. The course is designed to introduce researchers to the theoretical and practical aspects of the methods used for discovery and profiling of miRNA expression such as in-situ hybridization, microarray and qPCR analyses, fluorescent sorting and new-generation sequencing. [Invited Oral Presentation], MicroRNA profiling: From In-Situ Hybridization to New Gen Sequencing, EMBL-Montorontondo, Italy , 10-APR-10 - 16-APR-10. [Details]
	(1997)	The Biology of Proteolysis, Fearnhead, H; McCurrach, M; Lowe, S; Lazebnik, Y. (1997) Oncogene-dependent caspase activation. [Oral Presentation], The Biology of Proteolysis, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY , 23-APR-97 - 27-APR-97. [Details]

Invited papers

	Year	Publication
	(2005)	Oncogene dependent caspase activation. Univeristy of Texas, Austin. Fearnhead, H (2005) Oncogene dependent caspase activation. Univeristy of Texas, Austin. Invited papers [Details]
	(2005)	Oncogene dependent caspase activation. NA Rockville, Maryland, USA. Fearnhead, H (2005) Oncogene dependent caspase activation. NA Rockville, Maryland, USA. Invited papers [Details]
	(2004)	Oncogene dependent caspase activation. MRC Toxicology Unit, University of Leicester. Fearnhead (2004) Oncogene dependent caspase activation. MRC Toxicology Unit, University of Leicester. Invited papers [Details]