Biological and Chemical Sciences

Prof. Heinz-Peter Nasheuer

Biography

Scientific career & education

Since 2013 Personal Professor in Biochemistry, School of Natural Sciences, Nat. University of Ireland, Galway (NUI Galway).
2009 - 2013 Head of School of Natural Sciences, NUI Galway.
2007 - 2013 Senior Lecturer in Biochemistry.
2003 - 2007 Lecturer in the Biochemistry Dept., NUI Galway.
Since 01.2003 Permanent member of the Biochemistry Dept., NUI Galway.
1996 - 2002 Research group leader, Institute for Molecular Biotechnology Jena, Germany.
1990 - 1996 Junior Lecturer and research group leader at the University of Munich, Germany.
1988 - 1990 Postdoctoral fellowship of the German Research Council to work at Stanford School of Medicine, Stanford University, CA, USA.
1987 University of Hannover (Leibniz Universität Hannover), Germany, Dr. rer. nat.
1984 MSc in Biochemistry

Awards/ honours received

1999 Authorisation to lecture at a German university awarded by University of Jena
1999 Habilitation (2nd thesis to obtain a lectureship) awarded by University of Jena
1988 Postdoctoral fellowship awarded by the German Research Council
1987 Dr. rer. nat. with distinction; University of Hannover, Germany.

Reviewer for journals

Biochemica et Biophysica Acta, Journal of Cell Science, Chromosoma, EMBO Journal, FEBS Journal, FEBS Letters, Journal of Biological Chemistry, Journal of Molecular Biology, Journal of Molecular Medicine, Nucleic Acids Research, Oncogene and PLoS One.

Reviewer for the funding organisations and universities

Biotechnology and Biological Sciences Research Council, Medical Research Council, Wellcome Trust (all three UK), German Research Council, Boehringer Ingelheim Foundation (both Germany), and Telethon (Italy);
advisory referee in tenure issues for the University of Cambridge (UK), University of Iowa, Iowa, and Stanford University, Stanford (both USA)

Research Interests

cancer biology, cell cycle control, DNA replication, initiation, DNA repair signalling, protein biochemistry, cell biology, fluorescence correlation spectrocopy, protein-DNA and protein-protein interaction, microscopy

Peer Reviewed Journals

	Year	Publication
	(2019)	'Determination of the number of RAD51 molecules in different human cell lines' Foertsch, F,Kache, T,Drube, S,Biskup, C,Nasheuer, HP,Melle, C (2019) 'Determination of the number of RAD51 molecules in different human cell lines'. Cell Cycle, [DOI] [Details]
	(2019)	'ATPase activity of human binding immunoglobulin protein (BiP) variants is enhanced by signal sequence and physiological concentrations of Mn2+' Bandla, S;Diaz, S;Nasheuer, HP;FitzGerald, U (2019) 'ATPase activity of human binding immunoglobulin protein (BiP) variants is enhanced by signal sequence and physiological concentrations of Mn2+'. FEBS open bio, [DOI] [Details]
	(2003)	'Initiation of JC virus DNA replication in vitro by human and mouse DNA polymerase alpha-primase' Smith, RWP;Nasheuer, HP (2003) 'Initiation of JC virus DNA replication in vitro by human and mouse DNA polymerase alpha-primase'. European Journal Of Biochemistry, 270 :2030-2037 [DOI] [Details]
	(2004)	'Coordinated regulation of replication protein A activities by its subunits p14 and p32' Weisshart, K;Pestryakov, P;Smith, RWP;Hartmann, H;Kremmer, E;Lavrik, O;Nasheuer, HP (2004) 'Coordinated regulation of replication protein A activities by its subunits p14 and p32'. Journal Of Biological Chemistry, 279 :35368-35376 [DOI] [Details]
	(2004)	'Post-transcriptional expression regulation in the yeast Saccharomyces cerevisiae on a genomic scale' Beyer, A;Hollunder, J;Nasheuer, HP;Wilhelm, T (2004) 'Post-transcriptional expression regulation in the yeast Saccharomyces cerevisiae on a genomic scale'. Molecular & Cellular Proteomics, 3 :1083-1092 [DOI] [Details]
	(2006)	'DNA polymerase epsilon associates with the elongating form of RNA polymerase II and nascent transcripts' Rytkonen, AK;Hillukkala, T;Vaara, M;Sokka, M;Jokela, M;Sormunen, R;Nasheuer, HP;Nethanel, T;Kaufmann, G;Pospiech, H;Syvaoja, JE (2006) 'DNA polymerase epsilon associates with the elongating form of RNA polymerase II and nascent transcripts'. Febs Journal, 273 :5535-5549 [DOI] [Details]
	(2006)	'The Chk1-mediated S-phase checkpoint targets initiation factor Cdc45 via a Cdc25A/Cdk2-independent mechanism' Liu, PJ;Barkley, LR;Day, T;Bi, XH;Slater, DM;Alexandrow, MG;Nasheuer, HP;Vaziri, C (2006) 'The Chk1-mediated S-phase checkpoint targets initiation factor Cdc45 via a Cdc25A/Cdk2-independent mechanism'. Journal Of Biological Chemistry, 281 :30631-30644 [DOI] [Details]
	(2006)	'Distinctive activities of DNA polymerases during human DNA replication' Rytkonen, AK;Vaara, M;Nethanel, T;Kaufmann, G;Sormunen, R;Laara, E;Nasheuer, HP;Rahmeh, A;Lee, MYWT;Syvaoja, JE;Pospiech, H (2006) 'Distinctive activities of DNA polymerases during human DNA replication'. Febs Journal, 273 :2984-3001 [DOI] [Details]
	(2007)	'Mobility and distribution of replication protein A in living cells using fluorescence correlation spectroscopy' Braet, C;Stephan, H;Dobbie, IM;Togashi, DM;Ryder, AG;Foldes-Papp, Z;Lowndes, N;Nasheuer, HP (2007) 'Mobility and distribution of replication protein A in living cells using fluorescence correlation spectroscopy'. Experimental And Molecular Pathology, 82 :156-162 [DOI] [Details]
	(2007)	'Different activities of the largest subunit of replication protein A cooperate during SV40 DNA replication' Taneja, P;Boche, I;Hartmann, H;Nasheuer, HP;Grosse, F;Fanning, E;Weisshart, K (2007) 'Different activities of the largest subunit of replication protein A cooperate during SV40 DNA replication'. Febs Letters, 581 :3973-3978 [DOI] [Details]
	(2007)	'Timed interactions between viral and cellular replication factors during the initiation of SV40 in vitro DNA replication' Taneja, P;Nasheuer, HP;Hartmann, H;Grosse, F;Fanning, E;Weisshart, K (2007) 'Timed interactions between viral and cellular replication factors during the initiation of SV40 in vitro DNA replication'. Biochemical Journal, 407 :313-320 [DOI] [Details]
	(2007)	'Interactions of human Cdc45 with the Mcm2-7 complex, the GINS complex, and DNA polymerases delta and epsilon during S phase' Bauerschmidt, C;Pollok, S;Kremmer, E;Nasheuer, HP;Grosse, F (2007) 'Interactions of human Cdc45 with the Mcm2-7 complex, the GINS complex, and DNA polymerases delta and epsilon during S phase'. Genes To Cells, 12 :745-758 [DOI] [Details]
	(2007)	'Human Cdc45 is a proliferation-associated antigen' Pollok, S;Bauerschmidt, C;Sanger, J;Nasheuer, HP;Grosse, F (2007) 'Human Cdc45 is a proliferation-associated antigen'. Febs Journal, 274 :3669-3684 [DOI] [Details]
	(2009)	'Quantitative assignment of reaction directionality in constraint-based models of metabolism: Application to Escherichia coli' Fleming, RMT;Thiele, I;Nasheuer, HP (2009) 'Quantitative assignment of reaction directionality in constraint-based models of metabolism: Application to Escherichia coli'. Biophysical Chemistry, 145 :47-56 [DOI] [Details]
	(2009)	'Ionizing radiation-dependent and independent phosphorylation of the 32-kDa subunit of replication protein A during mitosis' Stephan, H;Concannon, C;Kremmer, E;Carty, MP;Nasheuer, HP (2009) 'Ionizing radiation-dependent and independent phosphorylation of the 32-kDa subunit of replication protein A during mitosis'. Nucleic Acids Research, 37 :6028-6041 [DOI] [Details]
	(2009)	'XRCC1 interacts with the p58 subunit of DNA Pol -primase and may coordinate DNA repair and replication during S phase' Levy, N;Oehlmann, M;Delalande, F;Nasheuer, HP;Van Dorsselaer, A;Schreiber, V;de Murcia, G;Menissier-de Murcia, J;Maiorano, D;Bresson, A (2009) 'XRCC1 interacts with the p58 subunit of DNA Pol -primase and may coordinate DNA repair and replication during S phase'. Nucleic Acids Research, 37 :3177-3188 [DOI] [Details]
	(2010)	'The Use of Transgenic Mice in Cancer and Genome Stability Research' Conmy, S;Nasheuer, HP (2010) 'The Use of Transgenic Mice in Cancer and Genome Stability Research'. Endotoxins: Structure, Function And Recognition, 50 :325-336 [DOI] [Details]
	(2010)	'Integrated stoichiometric, thermodynamic and kinetic modelling of steady state metabolism' Fleming, RMT;Thiele, I;Provan, G;Nasheuer, HP (2010) 'Integrated stoichiometric, thermodynamic and kinetic modelling of steady state metabolism'. Journal Of Theoretical Biology, 264 :683-692 [DOI] [Details]
	(2010)	'Eukaryotic Single-Stranded DNA Binding Proteins: Central Factors in Genome Stability' Broderick, S;Rehmet, K;Concannon, C;Nasheuer, HP (2010) 'Eukaryotic Single-Stranded DNA Binding Proteins: Central Factors in Genome Stability'. Endotoxins: Structure, Function And Recognition, 50 :143-163 [DOI] [Details]
	(2010)	'Host-Specific Replication of BK Virus DNA in Mouse Cell Extracts Is Independently Controlled by DNA Polymerase alpha-Primase and Inhibitory Activities' Tikhanovich, I;Nasheuer, HP (2010) 'Host-Specific Replication of BK Virus DNA in Mouse Cell Extracts Is Independently Controlled by DNA Polymerase alpha-Primase and Inhibitory Activities'. Virology Journal, 84 :6636-6644 [DOI] [Details]
	(2011)	'Inhibition of Human BK Polyomavirus Replication by Small Noncoding RNAs' Tikhanovich, I;Liang, B;Seoighe, C;Folk, WR;Nasheuer, HP (2011) 'Inhibition of Human BK Polyomavirus Replication by Small Noncoding RNAs'. Virology Journal, 85 :6930-6940 [DOI] [Details]
	(2012)	'Stimulation of BK Virus DNA Replication by NFI Family Transcription Factors' Liang, B;Tikhanovich, I;Nasheuer, HP;Folk, WR (2012) 'Stimulation of BK Virus DNA Replication by NFI Family Transcription Factors'. Virology Journal, 86 :3264-3275 [DOI] [Details]
	(2018)	'Optimizing fluorescent protein expression for quantitative fluorescence microscopy and spectroscopy using herpes simplex thymidine kinase promoter sequences' Ali, R;Ramadurai, S;Barry, F;Nasheuer, HP (2018) 'Optimizing fluorescent protein expression for quantitative fluorescence microscopy and spectroscopy using herpes simplex thymidine kinase promoter sequences'. FEBS open bio, 8 :1043-1060 [DOI] [Details]
	(2003)	'Physical and functional modularity of the protein network in yeast' Wilhelm, T;Nasheuer, HP;Huang, S (2003) 'Physical and functional modularity of the protein network in yeast'. Molecular & Cellular Proteomics, 2 :292-298 [DOI] [Details]
	(2003)	'Human replication protein A - The C-terminal RPA70 and the central RPA32 domains are involved in the interactions with the 3 '-end of a primer-template DNA' Pestryakov, PE;Weisshart, K;Schlott, B;Khodyreva, SN;Kremmer, E;Grosse, F;Lavrik, OI;Nasheuer, HP (2003) 'Human replication protein A - The C-terminal RPA70 and the central RPA32 domains are involved in the interactions with the 3 '-end of a primer-template DNA'. Journal Of Biological Chemistry, 278 :17515-17524 [DOI] [Details]
	(2015)	'The Contribution of William King to the Early Development of Palaeoanthropology' John Murray, Heinz Peter Nasheuer, Cathal Seoighe, Grace P McCormack, D Michael Williams, David AT Harper (2015) 'The Contribution of William King to the Early Development of Palaeoanthropology'. Irish Journal Of Earth Sciences, 33 :1-16 [DOI] [Details]
	(2014)	'Basic fibroblast growth factor modifies the hypoxic response of human bone marrow stromal cells by ERK-mediated enhancement of HIF-1 alpha activity' Fabian, Z,Ramadurai, S,Shaw, G,Nasheuer, HP,Kolch, W,Taylor, C,Barry, F (2014) 'Basic fibroblast growth factor modifies the hypoxic response of human bone marrow stromal cells by ERK-mediated enhancement of HIF-1 alpha activity'. Stem Cell Research, 12 :646-658 [DOI] [Details]
	(2014)	'PARG is dispensable for recovery from transient replicative stress but required to prevent detrimental accumulation of poly(ADP-ribose) upon prolonged replicative stress' Illuzzi, G, Fouquerel, E, Ame, JC, Noll, A, Rehmet, K, Nasheuer, HP, Dantzer, F, Schreiber, V (2014) 'PARG is dispensable for recovery from transient replicative stress but required to prevent detrimental accumulation of poly(ADP-ribose) upon prolonged replicative stress'. Nucleic Acids Research, 42 :7776-7792 [DOI] [Details]
	(2014)	'Interplay of DNA damage and cell cycle signaling at the level of human replication protein A' Borgstahl, GEO,Brader, K,Mosel, A,Liu, SQ,Kremmer, E,Goettsch, KA,Kolar, C,Nasheuer, HP,Oakley, GG (2014) 'Interplay of DNA damage and cell cycle signaling at the level of human replication protein A'. Dna Repair, 21 :12-23 [DOI] [Details]
	(2013)	'Cell cycle-dependent formation of Cdc45-Claspin complexes in human cells is compromized by UV-mediated DNA damage' Broderick, R,Rainey, MD,Santocanale, C,Nasheuer, HP (2013) 'Cell cycle-dependent formation of Cdc45-Claspin complexes in human cells is compromized by UV-mediated DNA damage'. Febs Journal, 280 :4888-4902 [DOI] [Details]
	(2012)	'Stimulation of BK Virus DNA Replication by NFI Family Transcription Factors' Liang, B,Tikhanovich, I,Nasheuer, HP,Folk, WR (2012) 'Stimulation of BK Virus DNA Replication by NFI Family Transcription Factors'. J Virol, 86 :3264-3275 [DOI] [Details]
	(2012)	'Segregation of Replicative DNA Polymerases during S Phase: DNA POLYMERASE epsilon, BUT NOT DNA POLYMERASES alpha/delta, ARE ASSOCIATED WITH LAMINS THROUGHOUT S PHASE IN HUMAN CELLS' Vaara, M, Itkonen, H, Hillukkala, T, Liu, Z, Nasheuer, HP, Schaarschmidt, D, Pospiech, H, Syvaoja, JE (2012) 'Segregation of Replicative DNA Polymerases during S Phase: DNA POLYMERASE epsilon, BUT NOT DNA POLYMERASES alpha/delta, ARE ASSOCIATED WITH LAMINS THROUGHOUT S PHASE IN HUMAN CELLS'. Journal Of Biological Chemistry, 287 :33327-33338 [DOI] [Details]
	(2012)	'Cell Cycle-Dependent Mobility of Cdc45 Determined in vivo by Fluorescence Correlation Spectroscopy' Broderick, R,Ramadurai, S,Toth, K,Togashi, DM,Ryder, AG,Langowski, J,Nasheuer, HP (2012) 'Cell Cycle-Dependent Mobility of Cdc45 Determined in vivo by Fluorescence Correlation Spectroscopy'. Plos One, 7 [DOI] [Details]
	(2011)	'Modification of Histones by Sugar beta-N-Acetylglucosamine (GlcNAc) Occurs on Multiple Residues, Including Histone H3 Serine 10, and Is Cell Cycle-regulated' Zhang, SS,Roche, K,Nasheuer, HP,Lowndes, NF (2011) 'Modification of Histones by Sugar beta-N-Acetylglucosamine (GlcNAc) Occurs on Multiple Residues, Including Histone H3 Serine 10, and Is Cell Cycle-regulated'. Journal Of Biological Chemistry, 286 :37483-37495 [DOI] [Details]
	(2011)	'Inhibition of Human BK Polyomavirus Replication by Small Noncoding RNAs' Tikhanovich, I., Liang, B., Seoighe, C., Folk, W. R., Nasheuer, H. P. (2011) 'Inhibition of Human BK Polyomavirus Replication by Small Noncoding RNAs'. J. Virol, 85 :6930-6940 [Details]
	(2010)	'Integrated stoichiometric, thermodynamic and kinetic modelling of steady state metabolism' Fleming, RMT,Thiele, I,Provan, G,Nasheuer, HP (2010) 'Integrated stoichiometric, thermodynamic and kinetic modelling of steady state metabolism'. Journal Of Theoretical Biology, 264 :683-692 [DOI] [Details]
	(2010)	'Host-Specific Replication of BK Virus DNA in Mouse Cell Extracts Is Independently Controlled by DNA Polymerase alpha-Primase and Inhibitory Activities' Tikhanovich, I,Nasheuer, HP (2010) 'Host-Specific Replication of BK Virus DNA in Mouse Cell Extracts Is Independently Controlled by DNA Polymerase alpha-Primase and Inhibitory Activities'. J Virol, 84 :6636-6644 [DOI] [Details]
	(2010)	'Eukaryotic Single-Stranded DNA Binding Proteins: Central Factors in Genome Stability' Broderick, S,Rehmet, K,Concannon, C,Nasheuer, HP,Nasheuer, HP (2010) 'Eukaryotic Single-Stranded DNA Binding Proteins: Central Factors in Genome Stability'. Genome Stability And Human Diseases, 50 :143-163 [DOI] [Details]
	(2010)	'The Use of Transgenic Mice in Cancer and Genome Stability Research' Conmy, S,Nasheuer, HP,Nasheuer, HP (2010) 'The Use of Transgenic Mice in Cancer and Genome Stability Research'. Genome Stability And Human Diseases, 50 :325-336 [DOI] [Details]
	(2009)	'Restriction of human polyomavirus BKV DNA replication in murine cells and extracts' Mahon, C., Liang, B., Tikhanovich, I., Abend, J.R., Imperiale, M.J., Nasheuer, H.P.* and Folk, W.R.* (2009) 'Restriction of human polyomavirus BKV DNA replication in murine cells and extracts'. J Virol, 83 (11):5708-5717 [ARAN Link] [Details]
	(2009)	'Quantitative assignment of reaction directionality in constraint-based models of metabolism: Application to Escherichia coli' Fleming, RMT,Thiele, I,Nasheuer, HP (2009) 'Quantitative assignment of reaction directionality in constraint-based models of metabolism: Application to Escherichia coli'. Biophysical Chemistry, 145 :47-56 [DOI] [Details]
	(2009)	'Ionizing radiation-dependent and independent phosphorylation of the 32-kDa subunit of replication protein A during mitosis' Stephan, H,Concannon, C,Kremmer, E,Carty, MP,Nasheuer, HP (2009) 'Ionizing radiation-dependent and independent phosphorylation of the 32-kDa subunit of replication protein A during mitosis'. Nucleic Acids Research, 37 :6028-6041 [DOI] [Details]
	(2009)	'XRCC1 interacts with the p58 subunit of DNA Pol -primase and may coordinate DNA repair and replication during S phase' Levy, N,Oehlmann, M,Delalande, F,Nasheuer, HP,Van Dorsselaer, A,Schreiber, V,de Murcia, G,Menissier-de Murcia, J,Maiorano, D,Bresson, A (2009) 'XRCC1 interacts with the p58 subunit of DNA Pol -primase and may coordinate DNA repair and replication during S phase'. Nucleic Acids Research, 37 :3177-3188 [DOI] [Details]
	(2008)	'Practical issues in the detection of multiscale spatial synchronization using empirical mode decomposition' Flemming, R.M.T. and Nasheuer, H.P. (2008) 'Practical issues in the detection of multiscale spatial synchronization using empirical mode decomposition'. Advances in Adaptive Data Analysis, [Details]
	(2007)	'Timed interactions between viral and cellular replication factors during the initiation of SV40 in vitro DNA replication' Taneja, P,Nasheuer, HP,Hartmann, H,Grosse, F,Fanning, E,Weisshart, K (2007) 'Timed interactions between viral and cellular replication factors during the initiation of SV40 in vitro DNA replication'. Biochemical Journal, 407 :313-320 [DOI] [Details]
	(2007)	'Different activities of the largest subunit of replication protein A cooperate during SV40 DNA replication' Taneja, P,Boche, I,Hartmann, H,Nasheuer, HP,Grosse, F,Fanning, E,Weisshart, K (2007) 'Different activities of the largest subunit of replication protein A cooperate during SV40 DNA replication'. Febs Letters, 581 :3973-3978 [DOI] [Details]
	(2007)	'Distinctive activities of DNA polymerases alpha, delta, and epsilon during human DNA replication' Rytkönen, A. K., Vaara, M., Nethanel, T., Kaufmann, G., Sormunen, R., Läärä, E., Nasheuer, H. P., Rahmeh, A., Lee, M. Y.W.T., Syväoja, J., and Pospiech, H. (2007) 'Distinctive activities of DNA polymerases alpha, delta, and epsilon during human DNA replication'. FEBS JOURNAL, 273 :2984-3001 [Details]
	(2007)	'Human Cdc45 is a proliferation-associated antigen' Pollok, S,Bauerschmidt, C,Sanger, J,Nasheuer, HP,Grosse, F (2007) 'Human Cdc45 is a proliferation-associated antigen'. Febs Journal, 274 :3669-3684 [DOI] [Details]
	(2007)	'Mobility and distribution of replication protein A in living cells using fluorescence correlation spectroscopy' Braet, C,Stephan, H,Dobbie, IM,Togashi, DM,Ryder, AG,Foldes-Papp, Z,Lowndes, N,Nasheuer, HP (2007) 'Mobility and distribution of replication protein A in living cells using fluorescence correlation spectroscopy'. Experimental And Molecular Pathology, 82 :156-162 [DOI] [Details]
	(2007)	'Interactions of human Cdc45 with the Mcm2-7 complex, the GINS complex, and DNA polymerases delta and epsilon during S phase' Bauerschmidt, C,Pollok, S,Kremmer, E,Nasheuer, HP,Grosse, F (2007) 'Interactions of human Cdc45 with the Mcm2-7 complex, the GINS complex, and DNA polymerases delta and epsilon during S phase'. Genes To Cells, 12 :745-758 [DOI] [Details]
	(2006)	'The Chk1-mediated S-phase checkpoint targets initiation factor Cdc45 via a Cdc25A/Cdk2-independent mechanism' Liu, PJ,Barkley, LR,Day, T,Bi, XH,Slater, DM,Alexandrow, MG,Nasheuer, HP,Vaziri, C (2006) 'The Chk1-mediated S-phase checkpoint targets initiation factor Cdc45 via a Cdc25A/Cdk2-independent mechanism'. Journal Of Biological Chemistry, 281 :30631-30644 [DOI] [Details]
	(2006)	'DNA polymerase epsilon associates with the elongating form of RNA polymerase II and nascent transcripts' Rytkonen, AK,Hillukkala, T,Vaara, M,Sokka, M,Jokela, M,Sormunen, R,Nasheuer, HP,Nethanel, T,Kaufmann, G,Pospiech, H,Syvaoja, JE (2006) 'DNA polymerase epsilon associates with the elongating form of RNA polymerase II and nascent transcripts'. Febs Journal, 273 :5535-5549 [DOI] [Details]
	(2006)	'Distinctive activities of DNA polymerases during human DNA replication' Rytkonen, AK,Vaara, M,Nethanel, T,Kaufmann, G,Sormunen, R,Laara, E,Nasheuer, HP,Rahmeh, A,Lee, MYWT,Syvaoja, JE,Pospiech, H (2006) 'Distinctive activities of DNA polymerases during human DNA replication'. Febs Journal, 273 :2984-3001 [DOI] [Details]
	(2004)	'Post-transcriptional expression regulation in the yeast Saccharomyces cerevisiae on a genomic scale' Beyer, A,Hollunder, J,Nasheuer, HP,Wilhelm, T (2004) 'Post-transcriptional expression regulation in the yeast Saccharomyces cerevisiae on a genomic scale'. Molecular & Cellular Proteomics, 3 :1083-1092 [DOI] [Details]
	(2004)	'Coordinated regulation of replication protein A activities by its subunits p14 and p32' Weisshart, K,Pestryakov, P,Smith, RWP,Hartmann, H,Kremmer, E,Lavrik, O,Nasheuer, HP (2004) 'Coordinated regulation of replication protein A activities by its subunits p14 and p32'. Journal Of Biological Chemistry, 279 :35368-35376 [DOI] [Details]
	(2003)	'Regulation of eukaryotic DNA replication at the initiation step by Cdc45 and DNA polymerase α phosphorylation' Pollok, S., Stoepel, J., Bauerschmidt, C., Kremmer, E., and Nasheuer, H.P. (2003) 'Regulation of eukaryotic DNA replication at the initiation step by Cdc45 and DNA polymerase α phosphorylation'. Biochemical Society Transactions, 31 :266-269 [Details]
	(2003)	'Partial proteolysis of SV40 T antigen reveals intramolecular contacts between domains and conformation changes upon hexamer assembly' Weisshart, K., Friedl, S., Taneja, P., Nasheuer, H.P., Schlott, B., Grosse, F. and Fanning, E. (2003) 'Partial proteolysis of SV40 T antigen reveals intramolecular contacts between domains and conformation changes upon hexamer assembly'. J Biol Chem, 279 :38943-38951 [Details]
	(2003)	'Physical and functional modularity of the protein network in yeast' Wilhelm, T,Nasheuer, HP,Huang, S (2003) 'Physical and functional modularity of the protein network in yeast'. Molecular & Cellular Proteomics, 2 :292-298 [DOI] [Details]
	(2003)	'Initiation of JC virus DNA replication in vitro by human and mouse DNA polymerase alpha-primase' Smith, RWP,Nasheuer, HP (2003) 'Initiation of JC virus DNA replication in vitro by human and mouse DNA polymerase alpha-primase'. European Journal Of Biochemistry, 270 :2030-2037 [DOI] [Details]
	(2003)	'Human replication protein A - The C-terminal RPA70 and the central RPA32 domains are involved in the interactions with the 3 '-end of a primer-template DNA' Pestryakov, PE,Weisshart, K,Schlott, B,Khodyreva, SN,Kremmer, E,Grosse, F,Lavrik, OI,Nasheuer, HP (2003) 'Human replication protein A - The C-terminal RPA70 and the central RPA32 domains are involved in the interactions with the 3 '-end of a primer-template DNA'. Journal Of Biological Chemistry, 278 :17515-17524 [DOI] [Details]
	(2002)	'Species specificity of Simian Virus 40 DNA replication in vitro requires multiple functions of human DNA polymerase α' Smith, R.W.P., Steffen, C., Grosse, F., and Nasheuer, H.P. (2002) 'Species specificity of Simian Virus 40 DNA replication in vitro requires multiple functions of human DNA polymerase α'. J Biol Chem, 277 :20541-20548 [Details]
	(2002)	'Physical and functional interactions of the tumor suppressor protein p53 and DNA polymerase α-primase' Melle, C. and Nasheuer, H.P. (2002) 'Physical and functional interactions of the tumor suppressor protein p53 and DNA polymerase α-primase'. Nucleic Acids Res, 30 :1493-1499 [Details]
	(2002)	'Control of complex formation of DNA polymerase α-primase and cell-free DNA replication by the C-terminal amino acids of the largest subunit p180?' Smith, R.W.P. and Nasheuer, H.P. (2002) 'Control of complex formation of DNA polymerase α-primase and cell-free DNA replication by the C-terminal amino acids of the largest subunit p180?'. Febs Letters, 527 :143-146 [Details]
	(2001)	'Two immunologically distinct human DNA polymerase α-primase subpopulations are involved in cellular DNA replication' Dehde, S., Rohaly, G., Schub, O., Nasheuer, H.P., Bohn, W. Chemnitz, J., Deppert, W., and Dornreiter, I. (2001) 'Two immunologically distinct human DNA polymerase α-primase subpopulations are involved in cellular DNA replication'. Mol Cell Biol, 21 :2581-2593 [Details]
	(2001)	'Aminoacids 257 to 288 of mouse p48 control the cooperation of polyomavirus large T antigen, replication protein A, and DNA polymerase α-primase to synthesize DNA in vitro' Kautz, A. R., Weisshart, K., Schneider, A., Grosse, F., and Nasheuer, H.P. (2001) 'Aminoacids 257 to 288 of mouse p48 control the cooperation of polyomavirus large T antigen, replication protein A, and DNA polymerase α-primase to synthesize DNA in vitro'. J Virol, 75 :8569-8578 [Details]
	(2001)	'Two independent phosphorylation sites of cellular DNA polymerase α-primase cooperate to regulate initiation of simian virus 40 DNA replication' Schub, O., Rohaly, G., Smith, R.W.P., Schneider, A., Dehde, S., Dornreiter, I., and Nasheuer, H.P. (2001) 'Two independent phosphorylation sites of cellular DNA polymerase α-primase cooperate to regulate initiation of simian virus 40 DNA replication'. J Biol Chem, 276 :38076-38083 [Details]
	(2001)	'A human topoisomerase I cleavage complex is recognized by an additional human topoisomerase I molecule in vitro' Søe, K., Dianov, G., Nasheuer, H.P., Bohr, V. A., Grosse, F. and Stevnsner, T. (2001) 'A human topoisomerase I cleavage complex is recognized by an additional human topoisomerase I molecule in vitro'. Nucleic Acids Res, 29 :3195-3203 [Details]
	(2000)	'Eukaryotic DNA polymerases, a growing family' Hübscher, U., Nasheuer, H.P., and Syväoja, J. (2000) 'Eukaryotic DNA polymerases, a growing family'. Trends In Biochemical Sciences, 25 :143-147 [Details]
	(2000)	'Protein-protein interactions of the primase subunits p58 and p48 with simian virus 40 T antigen are required for efficient primer synthesis in a cell-free system' Weisshart, K., Förster, H., Kremmer, E., Schlott, B., Grosse, F., and Nasheuer, H.P. (2000) 'Protein-protein interactions of the primase subunits p58 and p48 with simian virus 40 T antigen are required for efficient primer synthesis in a cell-free system'. J Biol Chem, 275 :17328-17337 [Details]
	(2000)	'Synthesis of base-substituted dUTP analogs carrying photoreactive 2-Nitro-5-azidobenzoyl group attached to 5'-position of uridine and its application to study human replication protein A by photoaffinity labeling' Kolpashchikov, D. M., Nasheuer, H.P., Weisshart, K., Ivanova, T. M., Bogachev, V. S., Favre, A., and Lavrik, O. I. (2000) 'Synthesis of base-substituted dUTP analogs carrying photoreactive 2-Nitro-5-azidobenzoyl group attached to 5'-position of uridine and its application to study human replication protein A by photoaffinity labeling'. Bioconjug. Chem, 11 :445-451 [Details]
	(2000)	'Different regions of primase subunit p48 control mouse polyomavirus and simian virus 40 DNA replication in vitro' Kautz, A. R., Schneider, A., Weisshart, K., Geiger, C., and Nasheuer, H.P. (2000) 'Different regions of primase subunit p48 control mouse polyomavirus and simian virus 40 DNA replication in vitro'. J Virol, 75 :1751-1760 [Details]
	(1999)	'RPA subunit arrangement near the 3'-end of the primer is modulated by the length of the template strand and cooperative protein interactions' Lavrik O.I., Kolpashchikov D.M., Weisshart K., Nasheuer H.P., Khodyreva S. N., and Favre A. (1999) 'RPA subunit arrangement near the 3'-end of the primer is modulated by the length of the template strand and cooperative protein interactions'. Nucleic Acids Res, 27 :4235-4240 [Details]
	(1999)	'Interaction of the RPA p70 subunit with a DNA template directs the p32 subunit to the 3´-end of nascent' Kolpashchikov, D. M., Weisshart, K., Nasheuer, H.P., Khodyreva, S. N., Fanning, E., Favre, A., and Lavrik, O. I. (1999) 'Interaction of the RPA p70 subunit with a DNA template directs the p32 subunit to the 3´-end of nascent'. Febs Lett, 450 :131-134 [Details]
	(1999)	'Cell cycle-dependent regulation of human DNA polymerase α-primase activity by phosphorylation' Voitenleitner, C., Rehfuess, C., Hilmes, M., O´Rear, L., Liao, P.-C., Gage, D. A., Ott, R., Nasheuer, H.P., and Fanning, E. (1999) 'Cell cycle-dependent regulation of human DNA polymerase α-primase activity by phosphorylation'. Mol Cell Biol, 19 :646-656 [Details]
	(1999)	'Surface plasmon resonance measurements reveal stable complex formation between tumorsuppressor gene product p53 and DNA polymerase ?-primase' Kühn, C., Müller, F., Melle, C., Nasheuer, H.P., Janus, F., Deppert, W., and Grosse F. (1999) 'Surface plasmon resonance measurements reveal stable complex formation between tumorsuppressor gene product p53 and DNA polymerase ?-primase'. Oncogene, 18 :769-774 [Details]
	(1998)	'Alternative RPA conformations are detected by crosslinks with primers carrying photoreactive group at 3'-end' Lavrik, O.I., Kolpashchikov, D. M., Nasheuer, H. P., Weisshart, K. and Favre, A. (1998) 'Alternative RPA conformations are detected by crosslinks with primers carrying photoreactive group at 3'-end'. Febs Lett, 441 :186-190 [Details]
	(1998)	'Primase activity of the DNA polymerase α-primase complex: Divalent cations stabilize the enzyme activity of the p48 subunit' Schneider, A., Smith, R. W. P., Kautz, A. R., Weisshart, K., Grosse, F. and Nasheuer, H. P. (1998) 'Primase activity of the DNA polymerase α-primase complex: Divalent cations stabilize the enzyme activity of the p48 subunit'. J Biol Chem, 273 :21608-21615 [Details]
	(1998)	'Subunits of human replication protein A are crosslinked by photoreactive primers synthesized by DNA polymerases' Lavrik, O. I., Nasheuer, H. P., Weisshart, K., Wold, M. S., Prasad, R., Beard, W. A., Wilson, A. H. and Favre, A. (1998) 'Subunits of human replication protein A are crosslinked by photoreactive primers synthesized by DNA polymerases'. Nucleic Acids Res, 26 :602-607 [Details]
	(1998)	'Poly ADP-ribose polymerase links the DNA damage surveillance network to the DNA replication machinery' Dantzer, F., Nasheuer, H. P., Vonesch, J.-L., de Murcia, G. and Ménissier-de Murcia, J. (1998) 'Poly ADP-ribose polymerase links the DNA damage surveillance network to the DNA replication machinery'. Nucleic Acids Res, 26 :1891-1898 [Details]
	(1997)	'A cell-free replication system for human polyomavirus' Nesper, J., Smith, R. W. P., Kautz, A. R., Sock, E., Wegner, M., Grummt, F., and Nasheuer, H. P. (1997) 'A cell-free replication system for human polyomavirus'. J Virol, 71 :7421-7428 [Details]
	(1997)	'Phosphorylation of DNA polymerase α-primase by cyclin A-dependent kinases regulates initiation of DNA replication in vitro' Voitenleitner, C., Fanning, E., and Nasheuer, H. P. (1997) 'Phosphorylation of DNA polymerase α-primase by cyclin A-dependent kinases regulates initiation of DNA replication in vitro'. Oncogene, 14 :1611-1615 [Details]
	(1996)	'Species-specific replication of simian virus 40 DNA in vitro requires the p180 subunit of human DNA polymerase α-primase' Stadlbauer, F., Voitenleitner, C., Brückner, A., Fanning, E., and Nasheuer, H. P. (1996) 'Species-specific replication of simian virus 40 DNA in vitro requires the p180 subunit of human DNA polymerase α-primase'. Mol Cell Biol, 16 :94-104 [Details]
	(1995)	'The mouse DNA polymerase α-primase subunit p48 mediates species- specific replication of polyomavirus DNA in vitro' Brückner, A., Stadlbauer, F., Guarino, L. A., Brunahl, A., Schneider, C., Rehfuess, C., Prives, C., Fanning, E. and Nasheuer, H. P. (1995) 'The mouse DNA polymerase α-primase subunit p48 mediates species- specific replication of polyomavirus DNA in vitro'. Mol Cell Biol, 15 :1716-1724 [Details]
	(1994)	'DNA replication in vitro by recombinant DNA-polymerase-α-primase' Stadlbauer, F., Brueckner, A., Rehfuess, C., Eckerskorn, C., Lottspeich, F., Förster, V., Tseng, B. Y. and Nasheuer, H. P. (1994) 'DNA replication in vitro by recombinant DNA-polymerase-α-primase'. Eur J Biochem, 222 :781-793 [Details]
	(1992)	'Purification and functional characterization of bovine RP-A in an in vitro SV40 DNA replication system' Nasheuer, H. P., von Winkler, D., Schneider, C., Dornreiter, I., Gilbert, I., and Fanning, E. (1992) 'Purification and functional characterization of bovine RP-A in an in vitro SV40 DNA replication system'. Chromosoma, 102 :52-59 [Details]
	(1991)	'Human DNA polymerase α gene: sequences controlling expression in cycling and serum-stimulated cells' Pearson, B. E., Nasheuer, H. P., and Wang, T. S. (1991) 'Human DNA polymerase α gene: sequences controlling expression in cycling and serum-stimulated cells'. Mol Cell Biol, 11 :2081-2095 [Details]
	(1991)	'Cell cycle-dependent phosphorylation of human DNA polymerase α' Nasheuer, H. P., Moore, A., Wahl, A. F. and Wang, T. S. (1991) 'Cell cycle-dependent phosphorylation of human DNA polymerase α'. J Biol Chem, 266 :7893-7903 [Details]
	(1989)	'DNA polymerase α-DNA primase from human placenta. Immunoaffinity purification and preliminary characterization' Podust, V. N., Lavrik, O. I., Nasheuer, H. P. and Grosse, F. (1989) 'DNA polymerase α-DNA primase from human placenta. Immunoaffinity purification and preliminary characterization'. Febs Lett, 245 :14-16 [Details]
	(1989)	'Exonucleolytic proof-reading increases the accuracy of DNA synthesis by human lymphocyte DNA polymerase α-DNA primase' Bialek, G., Nasheuer, H. P., Goetz, H. and Grosse, F. (1989) 'Exonucleolytic proof-reading increases the accuracy of DNA synthesis by human lymphocyte DNA polymerase α-DNA primase'. Embo J, 8 :1833-1839 [Details]
	(1988)	'DNA polymerase α-DNA primase from human lymphoblasts' Bialek, G., Nasheuer, H. P., Goetz, H., Behnke, B. and Grosse, F. (1988) 'DNA polymerase α-DNA primase from human lymphoblasts'. Biochim Biophys Acta, 951 :290-297 [Details]
	(1988)	'DNA polymerase α-primase from calf thymus: Determination of the polypeptide responsible for primase activity' Nasheuer, H. P. and Grosse, F. (1988) 'DNA polymerase α-primase from calf thymus: Determination of the polypeptide responsible for primase activity'. J Biol Chem, 263 :8981-8988 [Details]
	(1987)	'Immunoaffinity-purified DNA polymerase α displays novel properties' Nasheuer, H. P. and Grosse, F. (1987) 'Immunoaffinity-purified DNA polymerase α displays novel properties'. Biochemistry, 26 :8458-8466 [Details]
	(1986)	'Lactate dehydrogenase and glyceraldehyde-phosphate dehydrogenase are single-stranded DNA-binding proteins that affect the DNA-polymerase-α-primase complex' Grosse, F., Nasheuer, H. P., Scholtissek, S. and Schomburg, U. (1986) 'Lactate dehydrogenase and glyceraldehyde-phosphate dehydrogenase are single-stranded DNA-binding proteins that affect the DNA-polymerase-α-primase complex'. Eur J Biochem, 160 :459-467 [Details]
	(1985)	'Induction of alkaline phosphatase by retinoic acid' Freimüller-Kreutzer, B., Nasheuer, H. P. and Müller, W. H. (1985) 'Induction of alkaline phosphatase by retinoic acid'. Biol Chem Hoppe Seyler, 366 :317-321 [Details]

Books

	Year	Publication
	(2010)	Genome stability & human diseases. Nasheuer, HP (2010) Genome stability & human diseases. Berlin, Germany: Springer. [Details]

Book Chapters

	Year	Publication
	(2010)	'The use of transgenic mice in cancer and genome stability research' Conmy, S., and Nasheuer H.P. (2010) 'The use of transgenic mice in cancer and genome stability research' In: Genome stability and human diseases. Berlin: Springer. [Details]
	(2010)	'Eukaryotic single-stranded DNA binding proteins: Central factors in genome stability' Broderick, S, Rehmet, K., Concannon, C., and Nasheuer H.P. (2010) 'Eukaryotic single-stranded DNA binding proteins: Central factors in genome stability' In: Genome stability and human diseases. Berlin: Springer. [Details]
	(2008)	'Regulation of Eukaryotic DNA Replication at the Initiation Step' Pisani, F. M., De Felice, M., De Falco, M., Pollok, S. and Nasheuer, H.P. (2008) 'Regulation of Eukaryotic DNA Replication at the Initiation Step' In: DNA Replication, Repair and Recombination at the Crossroad Between Genome Integrity and Genomic Instability. Trivandrum, Indien: Research Signpost, Trans-world Research Network. [Details]
	(2006)	'Progress towards the anatomy of the eukaryotic DNA replication fork' Nasheuer, H.P., Pospiech, H., and Syväoja, J. (2006) 'Progress towards the anatomy of the eukaryotic DNA replication fork' In: Genome Integrity: Facets and Perspectives. Berlin, Germany: Springer. [Details]
	(2006)	'Human DNA Polymerases' Nasheuer, H.P., Pospiech, H., and Syväoja, J. (2006) 'Human DNA Polymerases' In: Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine. Berlin Heidelberg, Germany: Springer. [Details]
	(2000)	'DNA replication systems in vivo and in vitro as tools to study virus host interactions' Smith, R. W. P., and Nasheuer, H.P. (2000) 'DNA replication systems in vivo and in vitro as tools to study virus host interactions' In: Recent Research Developments in Virology. Trivandrum, India: Transworld Research Network. [Details]
	(1992)	'Bovine RBovine RP-A functions in SV40 DNA replication in vitro, but bovine DNA polymerase α-primase inhibits replication completely' Schneider, C., Winkler, D. v., Dornreiter, I., Nasheuer, H.P., Gilbert, I., Dehde, S., Arthur, A., and Fanning, E. (1992) 'Bovine RBovine RP-A functions in SV40 DNA replication in vitro, but bovine DNA polymerase α-primase inhibits replication completely' In: Regulatory Mechanisms of DNA Replication. Berlin, Germany: Springer. [Details]
	(1988)	'Structure and properties of the immunoaffinity-purified DNA polymerase α-primase complex' Grosse, F. and Nasheuer, H.P. (1988) 'Structure and properties of the immunoaffinity-purified DNA polymerase α-primase complex' In: Cancer Cells Vol. 6, Eukaryotic DNA Replication. Cold Spring Harbor, New York, USA: Cold Spring Harbor Press. [Details]

Conference Publications

	Year	Publication
	(2003)	*BIOCHEMICAL SOCIETY TRANSACTIONS* Pollok, S;Stoepel, J;Bauerschmidt, C;Kremmer, E;Nasheuer, HP (2003) Regulation of eukaryotic DNA replication at the initiation step BIOCHEMICAL SOCIETY TRANSACTIONS , pp.266-269 [Details]
	(2007)	*ADVANCES IN MOLECULAR ONCOLOGY* Oehlmann, M;Mahon, C;Nasheuer, HP (2007) Comparison of DNA replication in Xenopus laevis and Simian Virus 40 ADVANCES IN MOLECULAR ONCOLOGY , pp.3-16 [Details]
	(2009)	*BIOCHEMICAL SOCIETY TRANSACTIONS* Broderick, R,Nasheuer, HP (2009) Regulation of Cdc45 in the cell cycle and after DNA damage BIOCHEMICAL SOCIETY TRANSACTIONS , pp.926-930 [DOI] [Details]

Edited Books

	Year	Publication
	(2010)	Genome stability and human diseases. Nasheuer, H.P (Ed.). (2010) Genome stability and human diseases Genome stability and human diseases. Berlin: Springer. [Details]

Other Journals

	Year	Publication
	(2009)	'Regulation of Cdc45 in the Cell Cycle and after DNA damage' Broderick, R., and Nasheuer, H.P. (2009) 'Regulation of Cdc45 in the Cell Cycle and after DNA damage' Biochem Soc Trans, 37 :926-930. [Details]
	(2007)	'Comparison of DNA replication in Xenopus laevis and Simian Virus 40' Oehlmann, M., Mahon, C., and Nasheuer, H.P. (2007) 'Comparison of DNA replication in Xenopus laevis and Simian Virus 40' Adv Exp Med Biol, 604 :3-16. [Details]
	(2002)	'Initiation of Eukaryotic DNA Replication - Regulation and Mechanisms' Nasheuer, H.P., Smith, R. W. P., Bauerschmidt, C., Grosse, F., and Weisshart, K. (2002) 'Initiation of Eukaryotic DNA Replication - Regulation and Mechanisms' Prog Nucl Acid Res Mol Biol, 72 :41-94. [Details]
	(2001)	'Initiation of Eukaryotic DNA-Replication - A Protein Network Is Decoded' Bauerschmidt, C., Kremmer, E., and Nasheuer, H.P. (2001) 'Initiation of Eukaryotic DNA-Replication - A Protein Network Is Decoded' Bioforum, 24 :589-592. [Details]
	(1988)	'Twelfth Fritz Lipmann lecture. Initiation of transcription--a general tool for affinity labeling of RNA polymerases by autocatalysis' Hartmann, G. R., Biebricher, C., Glaser, S. J., Grosse, F., Katzameyer, M. J., Lindner, A. J., Mosig, H., Nasheuer, H.P., Rothman-Denes, L. B., Schäffner, A. R., Schnei¬der, G. J., Stetter, K.-O., and Thomm, M. (1988) 'Twelfth Fritz Lipmann lecture. Initiation of transcription--a general tool for affinity labeling of RNA polymerases by autocatalysis' Biol. Chem. Hoppe Seyler, 369 :775-788. [Details]

Abstract

	Year	Publication
	(2007)	Thermodynamically constrained steady state solution space of the E-coli metabolic network. Fleming, RMT,Golden, A,Nasheuer, HP (2007) Thermodynamically constrained steady state solution space of the E-coli metabolic network. Abstract [DOI] [Details]