Engineering

Dr Andrew Daly

B.A., B.A.I, Ph.D

Biography

Dr. Andrew Daly is an Assistant Professor in Biomedical Engineering at the National University of Ireland Galway. His research focuses on developing bioprinted models of tissue development and disease.

He was awarded a PhD in Mechanical Engineering from Trinity College Dublin in 2018, where he developed bioprinted implants for cartilage and bone regeneration. For this work he was awarded the Engineer's Ireland Biomedical Engineering Research Medal. Before this, he graduated with a First Class Honors Degree in Mechanical Engineering from Trinity College Dublin in 2013. In 2018, he moved to the University of Pennsylvania where he was awarded an American Heart Association Postdoctoral Fellowship to develop bioprinted disease models for drug screening applications.

To date, his work has been published in the top journals in the field including Nature Communications, Nature Reviews Materials, Cell, Biomaterials, Advanced Science, Acta Biomaterialia, Advanced Healthcare Materials, and Biofabrication.

Link to publications
https://scholar.google.com/citations?user=6aab09cAAAAJ&hl=en

Current Lab Members:
Sogol Kianersi - PhD Student - Bioprinted models of the placenta for drug screening - January 2022 to present
Ankita Pramanick - PhD Student - 4D Bioprinting shape-morphing tissues - September 2021 to present

Research Career:

2021 - present: Assistant Professor in Biomedical Engineering, College of Science and Engineering, NUI Galway

2021 - present: Funded Investigator at CÚRAM - Science Foundation Ireland Research Centre for Medical Devices

2018 - 2021: American Heart Association Postdoctoral Fellow, University of Pennsylvania, Philadelphia, USA

2013 - 2017: PhD Student, Trinity Centre for Bioengineering, Trinity College Dublin, Ireland

Research Interests

Research Overview
Our work focuses on developing enabling technologies for organ bioprinting. In particular, we create developmentally inspired bioprinting approaches leveraging embryonic processes such as stem cell condensation and tissue fusion. We are currently developing dynamic hydrogels that can program and scale these fundamental behaviours to engineer organs with advanced structural and functional properties.

Current Lab Members:
Sogol Kianersi - PhD Student - Bioprinted models of the placenta for drug screening - January 2022 to present
Ankita Pramanick - PhD Student - 4D Bioprinting shape-morphing tissues - September 2021 to present

Example publications
Bioprinted Tissue Models
https://www.nature.com/articles/s41467-021-21029-2
https://www.sciencedirect.com/science/article/abs/pii/S009286742031624X

Granular Hydrogels
https://onlinelibrary.wiley.com/doi/full/10.1002/advs.201801076
https://www.nature.com/articles/s41578-019-0148-6
https://www.sciencedirect.com/science/article/abs/pii/S1742706120306383

Cartilage and Bone Bioprinting
https://www.sciencedirect.com/science/article/abs/pii/S0142961218308639
https://iopscience.iop.org/article/10.1088/1758-5090/8/4/045002/meta
https://onlinelibrary.wiley.com/doi/abs/10.1002/adhm.201600182
https://onlinelibrary.wiley.com/doi/abs/10.1002/adhm.201700298
https://www.sciencedirect.com/science/article/abs/pii/S0142961218300772

Peer Reviewed Journals

	Year	Publication
	(2021)	'Bioprinting for the Biologist' Daly, Andrew C.,Prendergast, Margaret E.,Hughes, Alex J.,Burdick, Jason A. (2021) 'Bioprinting for the Biologist'. Cell, 184 (1):18-32 [Details]
	(2021)	'3D bioprinting of high cell-density heterogeneous tissue models through spheroid fusion within self-healing hydrogels' Daly, Andrew., Davidson, Matthew. D., Burdick, Jason.A. (2021) '3D bioprinting of high cell-density heterogeneous tissue models through spheroid fusion within self-healing hydrogels'. Nature Communications, [Details]
	(2021)	'Injectable hyaluronic acid and platelet lysate-derived granular hydrogels for biomedical applications' Mendes, BÃ¡rbara B.,Daly, Andrew C.,Reis, Rui L.,Domingues, Rui M.A.,Gomes, Manuela E.,Burdick, Jason A. (2021) 'Injectable hyaluronic acid and platelet lysate-derived granular hydrogels for biomedical applications'. Acta Biomaterialia, 119 :101-113 [Details]
	(2020)	'Hydrogel microparticles for biomedical applications' Daly, Andrew C.,Riley, Lindsay,Segura, Tatiana,Burdick, Jason A. (2020) 'Hydrogel microparticles for biomedical applications'. Nature Reviews Materials, 5 (1):20-43 [Details]
	(2020)	'The bioprinting roadmap' Sun, Wei,Starly, Binil,Daly, Andrew C,Burdick, Jason A,Groll, JÃ¼rgen,Skeldon, Gregor,Shu, Wenmiao,Sakai, Yasuyuki,Shinohara, Marie,Nishikawa, Masaki,Jang, Jinah,Cho, Dong-Woo,Nie, Minghao,Takeuchi, Shoji,Ostrovidov, Serge,Khademhosseini, Ali,Kamm, Roger D,Mironov, Vladimir,Moroni, Lorenzo,Ozbolat, Ibrahim T (2020) 'The bioprinting roadmap'. Biofabrication, 12 (2) [Details]
	(2019)	'Jammed Microgel Inks for 3D Printing Applications' Highley, Christopher B.,Song, Kwang Hoon,Daly, Andrew C.,Burdick, Jason A. (2019) 'Jammed Microgel Inks for 3D Printing Applications'. Advanced Science, 6 (1) [Details]
	(2019)	'Hypoxia mimicking hydrogels to regulate the fate of transplanted stem cells' Sathy, Binulal N.,Daly, Andrew,Gonzalez-Fernandez, Tomas,Olvera, Dinorath,Cunniffe, Grainne,McCarthy, Helen O.,Dunne, Nicholas,Jeon, Oju,Alsberg, Eben,Donahue, Tammy L. Haut,Kelly, Daniel J. (2019) 'Hypoxia mimicking hydrogels to regulate the fate of transplanted stem cells'. Acta Biomaterialia, 88 :314-324 [Details]
	(2019)	'Biofabrication of spatially organised tissues by directing the growth of cellular spheroids within 3D printed polymeric microchambers' Daly, Andrew C.,Kelly, Daniel J. (2019) 'Biofabrication of spatially organised tissues by directing the growth of cellular spheroids within 3D printed polymeric microchambers'. Biomaterials, 197 :194-206 [Details]
	(2018)	'Engineering large cartilage tissues using dynamic bioreactor culture at defined oxygen conditions' Daly, Andrew C,Sathy, Binulal N,Kelly, Daniel J (2018) 'Engineering large cartilage tissues using dynamic bioreactor culture at defined oxygen conditions'. Journal of Tissue Engineering, 9 [Details]
	(2018)	'3D printed microchannel networks to direct vascularisation during endochondral bone repair' Daly, Andrew C.,Pitacco, Pierluca,Nulty, Jessica,Cunniffe, GrÃ¡inne M.,Kelly, Daniel J. (2018) '3D printed microchannel networks to direct vascularisation during endochondral bone repair'. Biomaterials, 162 :34-46 [Details]
	(2017)	'Three-Dimensional Bioprinting of Polycaprolactone Reinforced Gene Activated Bioinks for Bone Tissue Engineering' Cunniffe, GrÃ¡inne M.,Gonzalez-Fernandez, Tomas,Daly, Andrew,Sathy, Binulal N.,Jeon, Oju,Alsberg, Eben,Kelly, Daniel J. (2017) 'Three-Dimensional Bioprinting of Polycaprolactone Reinforced Gene Activated Bioinks for Bone Tissue Engineering'. Tissue Engineering Part A, 23 (17-18):891-900 [Details]
	(2017)	'3D Bioprinting for Cartilage and Osteochondral Tissue Engineering' Daly, Andrew C.,Freeman, Fiona E.,Gonzalez-Fernandez, Tomas,Critchley, Susan E.,Nulty, Jessica,Kelly, Daniel J. (2017) '3D Bioprinting for Cartilage and Osteochondral Tissue Engineering'. Advanced Healthcare Materials, 6 (22) [Details]
	(2016)	'3D Bioprinting of Developmentally Inspired Templates for Whole Bone Organ Engineering' Daly, Andrew C.,Cunniffe, GrÃ¡inne M.,Sathy, Binulal N.,Jeon, Oju,Alsberg, Eben,Kelly, Daniel J. (2016) '3D Bioprinting of Developmentally Inspired Templates for Whole Bone Organ Engineering'. Advanced Healthcare Materials, 5 (18):2353-2362 [Details]
	(2016)	'A comparison of different bioinks for 3D bioprinting of fibrocartilage and hyaline cartilage' Daly, Andrew C,Critchley, Susan E,Rencsok, Emily M,Kelly, Daniel J (2016) 'A comparison of different bioinks for 3D bioprinting of fibrocartilage and hyaline cartilage'. Biofabrication, 8 (4) [Details]
	(2014)	'Shape-memory porous alginate scaffolds for regeneration of the annulus fibrosus: Effect of TGF-Î²3 supplementation and oxygen culture conditions' Guillaume, Olivier,Daly, Andrew,Lennon, Kerri,Gansau, Jennifer,Buckley, Shane F.,Buckley, Conor T. (2014) 'Shape-memory porous alginate scaffolds for regeneration of the annulus fibrosus: Effect of TGF-Î²3 supplementation and oxygen culture conditions'. Acta Biomaterialia, 10 (5):1985-1995 [Details]

Honours and Awards

Year	Title	Awarding Body
2019	American Heart Association Postdoctoral Fellowship	American Heart Association
2019	STAR Abstract Award, Society for Biomaterials	Society for Biomaterials
2019	Biofabrication Journal Outstanding Reviewer Award	Biofabrication Journal
2017	Article "A comparison of different bioinks for 3D bioprinting of fibrocartilage and hyaline cartilage¿ chosen as part of Biofabrication Journal "Highlights of 2016"	Biofabrication Journal
2017	Engineer's Ireland Biomedical Engineering Research Medal	Engineers Ireland

Professional Associations

	Association	Function	From / To
	Society for Biomaterials	Member	01-MAR-19 / 01-FEB-21
	International Society for Biofabrication	Early Career Researcher Committee	01-MAY-20 / 01-FEB-21