Biological and Chemical Sciences

Dr Erica Burnell

BSc., PhD

Biography

2017 - present Lecturer in Medicinal Chemistry, NUI Galway
2014 - 2017 Research Associate (Prof David Jane), University of Bristol
2009 - 2014 PhD in Organic Chemistry (Prof Jim Thomas), University of Manchester
2007 - 2008 Research Chemist (industrial placement), Boehringer Ingelheim, Germany
2005 - 2009 BSc in Medicinal Chemistry, Queen's University Belfast

Research Interests

My research interests lie in the field of natural products and medicinal chemistry. I use organic synthesis and ligand-based drug design to develop natural products and other small organic molecules with promising biological activity into suitable lead candidates for drug development.

Peer Reviewed Journals

	Year	Publication
	(2019)	'Positive and Negative Allosteric Modulators of N-Methyl-d-aspartate (NMDA) Receptors: Structure-Activity Relationships and Mechanisms of Action' Burnell ES;Irvine M;Fang G;Sapkota K;Jane DE;Monaghan DT; (2019) 'Positive and Negative Allosteric Modulators of N-Methyl-d-aspartate (NMDA) Receptors: Structure-Activity Relationships and Mechanisms of Action'. Journal Of Medicinal Chemistry, 62 (1) [DOI] [Details]
	(2019)	'Investigation of the structural requirements for N-methyl-D-aspartate receptor positive and negative allosteric modulators based on 2-naphthoic acid' Irvine MW;Fang G;Sapkota K;Burnell ES;Volianskis A;Costa BM;Culley G;Collingridge GL;Monaghan DT;Jane DE; (2019) 'Investigation of the structural requirements for N-methyl-D-aspartate receptor positive and negative allosteric modulators based on 2-naphthoic acid'. European Journal Of Medicinal Chemistry, 164 [DOI] [Details]
	(2019)	'The NMDA receptor intracellular C-terminal domains reciprocally interact with allosteric modulators' Sapkota K;Dore K;Tang K;Irvine M;Fang G;Burnell ES;Malinow R;Jane DE;Monaghan DT; (2019) 'The NMDA receptor intracellular C-terminal domains reciprocally interact with allosteric modulators'. Biochemical Pharmacology, 159 [DOI] [Details]
	(2018)	'Synthetic approaches to phomactins: Late stage stereochemical and reactivity issues' Burnell, ES;Irshad, AR;Lee, ATL;Thomas, EJ (2018) 'Synthetic approaches to phomactins: Late stage stereochemical and reactivity issues'. Tetrahedron, 74 :6737-6748 [DOI] [Details]
	(2017)	'Multiple roles of GluN2B-containing NMDA receptors in synaptic plasticity in juvenile hippocampus' France, G;Fernandez-Fernandez, D;Burnell, ES;Irvine, MW;Monaghan, DT;Jane, DE;Bortolotto, ZA;Collingridge, GL;Volianskis, A (2017) 'Multiple roles of GluN2B-containing NMDA receptors in synaptic plasticity in juvenile hippocampus'. Neuropharmacology, 112 :76-83 [DOI] [Details]
	(2017)	'Risk to heroin users of polydrug use of pregabalin or gabapentin' Lyndon, A;Audrey, S;Wells, C;Burnell, ES;Ingle, S;Hill, R;Hickman, M;Henderson, G (2017) 'Risk to heroin users of polydrug use of pregabalin or gabapentin'. Addiction, 112 :1580-1589 [DOI] [Details]
	(2017)	'Mechanism and properties of positive allosteric modulation of N-methyl-D-aspartate receptors by 6-alkyl 2-naphthoic acid derivatives' Sapkota, K;Irvine, MW;Fang, GY;Burnell, ES;Bannister, N;Volianskis, A;Gulley, GR;Dravid, SM;Collingridge, GL;Jane, DE;Monaghan, DT (2017) 'Mechanism and properties of positive allosteric modulation of N-methyl-D-aspartate receptors by 6-alkyl 2-naphthoic acid derivatives'. Neuropharmacology, 125 :64-79 [DOI] [Details]
	(2016)	'Assessment of Methods for the Intracellular Blockade of GABA(A) Receptors' Atherton, LA;Burnell, ES;Mellor, JR (2016) 'Assessment of Methods for the Intracellular Blockade of GABA(A) Receptors'. Plos One, 11 [DOI] [Details]
	(2016)	'Stereoselective synthesis of oxazolidinonyl-fused piperidines of interest as selective muscarinic (M-1) receptor agonists: a novel M-1 allosteric modulator' Broadley, KJ;Buffat, MGP;Burnell, E;Davies, RH;Moreau, X;Snee, S;Thomas, EJ (2016) 'Stereoselective synthesis of oxazolidinonyl-fused piperidines of interest as selective muscarinic (M-1) receptor agonists: a novel M-1 allosteric modulator'. Organic & Biomolecular Chemistry, 14 :2057-2089 [DOI] [Details]
	(2016)	'The synthesis of a series of adenosine A(3) receptor agonists' Broadley, KJ;Burnell, E;Davies, RH;Lee, ATL;Snee, S;Thomas, EJ (2016) 'The synthesis of a series of adenosine A(3) receptor agonists'. Organic & Biomolecular Chemistry, 14 :3765-3781 [DOI] [Details]
	(2015)	'Approaches to phomactin A: unexpected late-stage observations' Burnell, ES;Irshad, AR;Raftery, J;Thomas, EJ (2015) 'Approaches to phomactin A: unexpected late-stage observations'. Tetrahedron Letters, 56 :3255-3258 [DOI] [Details]
	(2015)	'Synthesis of a Series of Novel 3,9-Disubstituted Phenanthrenes as Analogues of Known N-Methyl-D-aspartate Receptor Allosteric Modulators' Irvine, MW;Fang, GY;Eaves, R;Mayo-Martin, MB;Burnell, ES;Costa, BM;Culley, GR;Volianskis, A;Collingridge, GL;Monaghan, DT;Jane, DE (2015) 'Synthesis of a Series of Novel 3,9-Disubstituted Phenanthrenes as Analogues of Known N-Methyl-D-aspartate Receptor Allosteric Modulators'. Synthesis-Stuttgart, 47 :1593-1610 [DOI] [Details]

Book Chapters

	Year	Publication
	(2016)	'Ligand-based Drug Design' Erica S. Burnell, David E. Jane, Robert, J. Thatcher (2016) 'Ligand-based Drug Design' In: Textbook of Drug Design and Discovery. USA: CRC Press, Taylor & Francis Group. [Details]

Professional Associations

	Association	Function	From / To
	Royal Society of Chemistry	Member	13-APR-17 /

Employment

	Employer	Position	From / To
	University of Bristol	Research Associate	01-MAR-14 / 31-OCT-17

Education

	Year	Institution	Qualification	Subject
	2013	University of Manchester	PhD	Organic chemistry
	2009	Queen's University Belfast	BSc	Medicinal Chemistry with Year in Industry

Modules Taught

Term/Year	Module Title	Module Code
Semester 2	Medicinal Chemistry	CH2101
Semester 1	Drug Design and Drug Discovery	CH332
Semester 1	Analytical Chemistry and Molecular Structure	CH326
Semester 1	Experimental Chemistry	CH333
Semester 1	Core Skills for Chemistry Research	CH506
Semester 1	Techniques and Skills for Chemistry Research	CH5102