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About University of Galway
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Biological and Chemical Sciences
Dr Enda O'Connell
Contact Details
Biomedical Sciences Building
NUI Galway
Upper Newcastle
Galway
T: Ext. 5435
E: enda.oconnell@nuigalway.ie

Biography
Research Interests
Research Projects
Project | Start Date | End Date | |
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ReelLIFE SCIENCE Video Competition | 01-JAN-18 | 31-DEC-22 | |
ReelLIFE SCIENCE Video Competition | 01-JAN-17 | 31-DEC-17 | |
ReelLIFE SCIENCE Video Competition | 01-JAN-20 | 31-DEC-20 | |
ReelLIFE SCIENCE Video Competition | 01-JAN-19 | 06-JUL-20 |
Peer Reviewed Journals
Year | Publication | |
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(2020) | 'Preliminary Evidence of Bioactivity from Deep Sea Coral and Sponge Extracts: Influencing Human Stem Cell Growth and Differentiation'
Louise Allcock and Marchese, Pietro and Young, Ryan and O'Connell, Enda and Baker, Bill J. and Johnson, Mark and Fearnhead, Howard and Allcock, Louise and Murphy, Mary (2020) 'Preliminary Evidence of Bioactivity from Deep Sea Coral and Sponge Extracts: Influencing Human Stem Cell Growth and Differentiation'. Marine Drugs, [Details] |
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(2021) | 'Deep-Sea Coral Garden Invertebrates and Their Associated Fungi Are Genetic Resources for Chronic Disease Drug Discovery'
Marchese P, Young R, O'Connell E, Afoullouss S, Baker BJ, Allcock AL, Barry F, Murphy JM (2021) 'Deep-Sea Coral Garden Invertebrates and Their Associated Fungi Are Genetic Resources for Chronic Disease Drug Discovery'. Marine Drugs, [Details] |
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(2021) | 'A robust platform for high-throughput screening of therapeutic strategies for acute and chronic spinal cord injury'
Patil V;O'Connell E;Quinlan LR;Fearnhead H;McMahon S;Pandit A; (2021) 'A robust platform for high-throughput screening of therapeutic strategies for acute and chronic spinal cord injury'. Iscience, 24 (3) [DOI] [Details] |
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(2020) | 'Apoptosome-dependent myotube formation involves activation of caspase-3 in differentiating myoblasts'
H Dehkordi M;Tashakor A;O'Connell E;Fearnhead HO; (2020) 'Apoptosome-dependent myotube formation involves activation of caspase-3 in differentiating myoblasts'. Cell Death And Disease, 11 (5) [DOI] [Details] |
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(2020) | 'Diversity and bioactivity of fungi associated with the marine sea cucumber Holothuria poli: disclosing the strains potential for biomedical applications'
Marchese, P;Garzoli, L;Gnavi, G;O'Connell, E;Bouraoui, A;Mehiri, M;Murphy, JM;Varese, GC (2020) 'Diversity and bioactivity of fungi associated with the marine sea cucumber Holothuria poli: disclosing the strains potential for biomedical applications'. Journal Of Applied Microbiology, [DOI] [Details] |
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(2020) | 'A Novel High-Throughput Screening Platform Identifies Itaconate Derivatives from Marine Penicillium antarcticum as Inhibitors of Mesenchymal Stem Cell Differentiation'
Marchese P;Mahajan N;O'Connell E;Fearnhead H;Tuohy M;Krawczyk J;Thomas OP;Barry F;Murphy MJ; (2020) 'A Novel High-Throughput Screening Platform Identifies Itaconate Derivatives from Marine Penicillium antarcticum as Inhibitors of Mesenchymal Stem Cell Differentiation'. Marine Drugs, 18 (4) [DOI] [Details] |
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(2019) | 'Droplet Combinations: A Scalable Microfluidic Platform for Biochemical Assays'
Cliffe, FE,Lyons, M,Murphy, DC,McInerney, L,Hurley, N,Galvin, MA,Mulqueen, J,Bible, LB,Marella, C,Kelleher, M,O'Sullivan, A,Fearnhead, HO,O'Connell, E,Davies, M (2019) 'Droplet Combinations: A Scalable Microfluidic Platform for Biochemical Assays'. Slas Technology, [DOI] [Details] |
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(2019) | 'A new split-luciferase complementation assay identifies pentachlorophenol as an inhibitor of apoptosome formation'
Tashakor, A,H-Dehkordi, M,O'Connell, E,Ganau, SG,Gozalbes, R,Eriksson, LA,Hosseinkhani, S,Fearnhead, HO (2019) 'A new split-luciferase complementation assay identifies pentachlorophenol as an inhibitor of apoptosome formation'. FEBS open bio, 9 :1194-1203 [DOI] [Details] |
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(2017) | 'Isolation and synthesis of pygmanilines, phenylurea derivatives from the Northeastern Atlantic lichen Lichina pygmaea'
Mahajan, N,Chadda, R,Calabro, K,Solanki, H,O'Connell, E,Murphy, PV,Thomas, OP (2017) 'Isolation and synthesis of pygmanilines, phenylurea derivatives from the Northeastern Atlantic lichen Lichina pygmaea'. Tetrahedron Letters, 58 :1237-1239 [DOI] [Details] |
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(2016) | 'Effects of combined progesterone and 17 beta-estradiol treatment on the transcriptome of cultured human myometrial smooth muscle cells'
Chandran, S,Cairns, MT,O'Brien, M,O'Connell, E,Mashayekhi, K,Smith, TJ (2016) 'Effects of combined progesterone and 17 beta-estradiol treatment on the transcriptome of cultured human myometrial smooth muscle cells'. Physiological Genomics, 48 :50-61 [DOI] [ARAN Link] [Details] |
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(2016) | 'Sensitivity Profiles of Human Prostate Cancer Cell Lines to an 80 Kinase Inhibitor Panel'
Burke, AJ;Ali, H;O'Connell, E;Sullivan, FJ;Glynn, SA (2016) 'Sensitivity Profiles of Human Prostate Cancer Cell Lines to an 80 Kinase Inhibitor Panel'. Anticancer Research, 36 (2):633-641 [Details] |
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(2014) | 'Post‐traumatic immunosuppression is reversed by anti‐coagulated salvaged blood transfusion: deductions from studying immune status after knee arthroplasty'
Islam N, Whitehouse M, Mehendale S, Hall M, Tierney J, O'Connell E, Blom A, Bannister G, Hinde J, Ceredig R, Bradley BA. (2014) 'Post‐traumatic immunosuppression is reversed by anti‐coagulated salvaged blood transfusion: deductions from studying immune status after knee arthroplasty'. Clin Exp Immunol, 177 (2):509-520 [DOI] [Details] |
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(2014) | 'A high through-put screen for small molecules modulating MCM2 phosphorylation identifies Ryuvidine as an inducer of the DNA damage response'
FitzGerald J, Murillo LS, O'Brien G, O'Connell E, O'Connor A, Wu K, Wang GN, Rainey MD, Natoni A, Healy S, O'Dwyer M, Santocanale C (2014) 'A high through-put screen for small molecules modulating MCM2 phosphorylation identifies Ryuvidine as an inducer of the DNA damage response'. Plos One, 9 (6) [DOI] [Details] |
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(2014) | 'Inhibition of protein synthesis and JNK activation are not required for cell death induced by anisomycin and anisomycin analogues'
Monaghan D, O'Connell E, Cruickshank FL, O'Sullivan B, Giles FJ, Hulme AN, Fearnhead HO (2014) 'Inhibition of protein synthesis and JNK activation are not required for cell death induced by anisomycin and anisomycin analogues'. Biochem, 443 (2):761-767 [DOI] [Details] |
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(2014) | 'Co-acting gene networks predict TRAIL responsiveness of tumour cells with high accuracy'
O'Reilly, P,Ortutay, C,Gernon, G,O'Connell, E,Seoighe, C,Boyce, S,Serrano, L,Szegezdi, E (2014) 'Co-acting gene networks predict TRAIL responsiveness of tumour cells with high accuracy'. BMC Genomics, 15 [DOI] [Details] |
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(2013) | 'The novel toluidine sulphonamide EL102 shows pre-clinical in vitro and in vivo activity against prostate cancer and circumvents MDR1 resistance'
Toner, AP;McLaughlin, F;Giles, FJ;Sullivan, FJ;O'Connell, E;Carleton, LA;Breen, L;Dunne, G;Gorman, AM;Lewis, JD;Glynn, SA (2013) 'The novel toluidine sulphonamide EL102 shows pre-clinical in vitro and in vivo activity against prostate cancer and circumvents MDR1 resistance'. British Journal Of Cancer, 109 :2131-2141 [DOI] [Details] |
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(2012) | 'A comparison of the efficacy of transplantation of bone marrow-derived mesenchymal stem cells and unrestricted somatic stem cells on outcome after acute myocardial infarction'
Flynn, A;Chen, XZ;O'Connell, E;O'Brien, T (2012) 'A comparison of the efficacy of transplantation of bone marrow-derived mesenchymal stem cells and unrestricted somatic stem cells on outcome after acute myocardial infarction'. Stem Cell Research & Therapy, 3 [DOI] [Details] |
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(2012) | 'A Role for MRP8 in in stent restenosis in diabetes'
Stocca, A,O'Toole, D,Hynes, N,Hynes, SO,Mashayekhi, K,McGinley, L,O'Connell, E,Coleman, C,Sultan, S,Duffy, A,Tunev, S,O'Brien, T (2012) 'A Role for MRP8 in in stent restenosis in diabetes'. Atherosclerosis, 221 :325-332 [DOI] [Details] |
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(2011) | 'Regulation of the DNA damage response and gene expression by the Dot1L histone methyltransferase and the 53Bp1 tumour suppressor'
FitzGerald J, Moureau S, Drogaris P, O'Connell E, Abshiru N, Verreault A, Thibault P, Grenon M, Lowndes NF. (2011) 'Regulation of the DNA damage response and gene expression by the Dot1L histone methyltransferase and the 53Bp1 tumour suppressor'. Plos One, 6 (2) [DOI] [Details] |
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(2011) | 'The vapA co-expressed virulence plasmid gene vcgB (orf10) of the intracellular actinomycete Rhodococcus equi'
Miranda-Casoluengo R, Miranda-Casoluengo AA, O'Connell EP, Fahey RJ, Boland CA, Vázquez-Boland JA, Meijer WG (2011) 'The vapA co-expressed virulence plasmid gene vcgB (orf10) of the intracellular actinomycete Rhodococcus equi'. Microbiology, 157 (Pt 8):2357-2368 [DOI] [Details] |
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(2010) | 'Gene expression analysis of the microvascular compartment in multiple sclerosis using laser microdissected blood vessels'
Cunnea, P;McMahon, J;O'Connell, E;Mashayekhi, K;Fitzgerald, U;McQuaid, S (2010) 'Gene expression analysis of the microvascular compartment in multiple sclerosis using laser microdissected blood vessels'. Acta Neuropathologica, 119 :601-615 [DOI] [Details] |
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(2008) | 'Differential mRNA stability of the vapAICD operon of the facultative intracellular pathogen Rhodococcus equi'
Byrne GA, Boland CA, O'Connell EP, Meijer WG (2008) 'Differential mRNA stability of the vapAICD operon of the facultative intracellular pathogen Rhodococcus equi'. Fems Microbiology Letters, 280 (1):89-94 [DOI] [Details] |
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(2008) | 'Human coronary artery smooth muscle cell response to a novel PLA textile/fibrin gel composite scaffold'
Gundy S, Manning G, O'Connell E, Ellä V, Harwoko MS, Rochev Y, Smith T, Barron V (2008) 'Human coronary artery smooth muscle cell response to a novel PLA textile/fibrin gel composite scaffold'. Acta Biomaterialia, 4 (6):1734-1744 [DOI] [Details] |
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(2005) | 'The iron-regulated iupABC operon is required for saprophytic growth of the intracellular pathogen Rhodococcus equi at low iron concentrations'
Miranda-Casoluengo R, Duffy PS, O'Connell EP, Graham BJ, Mangan MW, Prescott JF, Meijer WG (2005) 'The iron-regulated iupABC operon is required for saprophytic growth of the intracellular pathogen Rhodococcus equi at low iron concentrations'. Journal Of Bacteriology, 187 (10):3438-3444 [DOI] [Details] |
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(2004) | 'The LysR-type transcriptional regulator VirR is required for expression of the virulence gene vapA of Rhodococcus equi ATCC 33701'
Russell DA, Byrne GA, O'Connell EP, Boland CA, Meijer WG (2004) 'The LysR-type transcriptional regulator VirR is required for expression of the virulence gene vapA of Rhodococcus equi ATCC 33701'. Journal Of Bacteriology, 186 (17):5576-5584 [DOI] [Details] |
Book Chapters
Year | Publication | |
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(2012) | 'Evaluating the potential of quantum dots for in vitro biological studies: effects on gene expression using microarray analysis'
Prasad BR, O'Connell E, Smith TJ, Gérard VA, Gun'ko YK, Rochev Y (2012) 'Evaluating the potential of quantum dots for in vitro biological studies: effects on gene expression using microarray analysis' In: Nanoparticles in Biology and Medicine: Methods and Protocols. :171-183 Clifton, N.J: Methods in Molecular Biology. [DOI] [Details] |
Conference Publications
Year | Publication | |
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(2018) | XI European Conference on Marine Natural Products Portugal
Marchese, P; Young, R; O¿Connell, E; Baker, B; Johnson, M; Fearnhead, H; Allcock, L; Murphy, M. (2018) Preliminary evidence of bioactivity from deep sea coral and sponge extracts: influencing human stem cell growth and differentiation XI European Conference on Marine Natural Products Portugal [Details] |
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(2017) | 25th Euroconference on Apoptosis
Tashakor, A; Dehkordi, M; O'Connell, E; Hosseinkhani, S;Fearnhead, H. (2017) Identifying Apaf-1 inhibitors using a new split luciferase assay 25th Euroconference on Apoptosis [Details] |
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(2015) | AACR 106th Annual Meeting 2015
Husnain Ali, Amy Burke, Enda O'Connell, Frank Sullivan, Frank Giles and Sharon Glynn (2015) GSK3¿/ß inhibition as a drug target in prostate cancer . In: Cancer Research eds. AACR 106th Annual Meeting 2015 [Details] |
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(2014) | Irish Association for Cancer Research
Cuffe, S; O’Connell, E; Morrison, C (2014) Inducing Centrosome Amplification to Radiosensitise Prostate Cancer Cells Irish Association for Cancer Research [Details] |
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(2014) | Irish Association for Cancer Research
O'Reilly, P; O'Connell, E; Gernon, G; Szegezdi, E. (2014) Panel of 25 co-acting genes identified as a powerful predictor of TRAIL sensitivity Irish Association for Cancer Research [Details] |
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(2014) | Irish Association for Cancer Research
Toner, AP; Giles, FJ; Carleton, LA; O’Connell, E; Harte, E; Breen, L; Dunne. G; Clynes, M; Lewis, JD; Gorman, AM; Sullivan, FJ; Glynn, SA. (2014) Characterisation of a new class of prostate cancer chemotherapeutics Irish Association for Cancer Research [Details] |
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(2014) | Irish Association for Cancer Research
Ali, H; Burke, A; O’Connell, E; Giles, FJ; Sullivan, F; Glynn, S. (2014) Novel Kinase Inhibitors as Drug Targets in Prostate Cancer Irish Association for Cancer Research [Details] |
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(2014) | Irish Association for Cancer Research
Fitzgerald, J; Murillo, L; O’Brien, G; O’Connell, E; O’Connor, A; Wu, K; Wang, GN; Rainey, MD; Natoni, A; Healy, S; O’Dwyer, M; Santocanale, C (2014) A high through put screen identifies Ryuvidine as a modulator of Cdc7 dependent phosphorylation of MCM2 and an inducer of the DNA damage response Irish Association for Cancer Research [Details] |
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(2013) | British Association of Urological Surgeons AGM
Toner, AP; McLaughlin, F; Giles, FJ; Sullivan, FJ; O’Connell, E; Carleton, LA; Breen, L; Gorman , AM; Lewis, JD and Glynn, SA. (2013) Introducing Novel Toluidine Sulphonamide EL102: A Potential Chemotherapeutic In Prostate Cancer British Association of Urological Surgeons AGM [Details] |
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(2013) | American Society for Cell Biology
Sandra Cuffe, Enda O'Connell, Ciaran Morrison (2013) Centrosome amplification as a strategy for radio-sensitisation of prostate cancer American Society for Cell Biology New Orleans, USA, , 14-DEC-13 - 18-DEC-13 [Details] |
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(2013) | Irish Association for Cancer Research
Cuffe, S; Gaboriau, D; O’Connell, E; Morrison, C (2013) Centrosome amplification as a strategy for radiosensitization of prostate cancer Irish Association for Cancer Research [Details] |
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(2013) | Academic Screening Workshop
Toner, AP; Burke, A; Giles, FJ; Harte, E; Carleton, LA; O’Connell, E; Lewis, JD; Glynn, SA. (2013) Preclicincal analysis of EL102, a novel compound proposed for the treatment of prostate cancer Academic Screening Workshop Baltimore, MD, USA, [Details] |
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(2013) | Irish Association for Cancer Research
Murillo, L; Natoni, A; O’Connell, E; Fitzgerald, J; O’Dwyer, M; Santocanale, C (2013) Development of a High-Throughput Screening assay for the identification of compounds affecting Cdc7 dependent MCM helicase phosphorylation Irish Association for Cancer Research [Details] |
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(2012) | Royal Academy of Medicine in Ireland Annual Meeting
Burke, AJ; O'Connell, E; Miranda, KM; Giles, FJ; Sullivan, F; Glynn, SA (2012) Nitric Oxide and its effects on cellular proliferation and phenotype in prostate cancer Royal Academy of Medicine in Ireland Annual Meeting NUI Galway, Ireland, [Details] |
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(2011) | American College of Cardiology
Flynn, A; Chen, XZ; O'Connell, E; Barry, F; O'Brien, T. (2011) The Pre-Conditioning of Unrestricted Somatic Stem Cells Alters Their Genotype, but Does Not Enhance Their Ability to Repair Cardiac Damage American College of Cardiology , pp.209-209 [Details] |
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(2010) | Irish Cardiac Society AGM
Flynn, A,Chen, X,O'Connell, E,Duffy, A,Shaw, G,O'Loughlin, A,Dennedy, C,McHale, C,MacNeill, B,Nash, P,Crowley, J,Daly, K,Barry, F,O'Brien, T (2010) Unrestricted Somatic Stem Cells Improve Cardiac Function Post-Myocardial Infarction With and Without Pre-Conditioning. Authors Irish Cardiac Society AGM , pp.401-402 [Details] |
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(2010) | Irish Thoracic Society
Sharma, K; Talbot, A; Saleem, I; O'Connell, E; Rutherford, R; Gilmartin, JJ; O'Regan, A. (2010) Specific epithelial gene expression profile in acute sarcoidosis Irish Thoracic Society Cork, Ireland, , pp.492-492 [Details] |
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(2010) | Tissue Engineering and Regenerative Medicine International Society (TERMIS-EU)
McCullagh K; Hughes O; Cooney R; O'Connell E; Mashayekhi K; Eglon M; O' Brien T. (2010) Gene Profile Analysis of NOS Transduced Human Arterial Smooth Muscle Cells Tissue Engineering and Regenerative Medicine International Society (TERMIS-EU) [Details] |
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(2009) | Society of Gynecological Investigation 56th Annual Meeting
Chandran, S; Mashayekhi, K; O'Connell, E; O'Brien, M; Smith, T. (2009) Estrogen Induced Differential Expression of Genes in Human Uterine Smooth Muscle Cells - A Global Analysis Society of Gynecological Investigation 56th Annual Meeting Glasgow, UK, , 17-MAR-09 - 21-MAR-09 , pp.112-113 [Details] |
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(2004) | Society for General Microbiology 155th Meeting
Byrne, GA; Russell, DA; O'Connell, EP; Meijer, WG. (2004) Transcriptional organisation and regulation of the vapA locus of the intracellular pathogen Rhodococcus equi Society for General Microbiology 155th Meeting Trinity College Dublin, Ireland, [Details] |
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(2004) | Society for General Microbiology - Irish Branch
Russell, DA; Byrne, GA; O'Connell, EP; Boland, CA; Meijer, WG. (2004) The LysR-Type Transcriptional Regulator VirR is Required for Expression of the Virulence Gene vapA of Rhodococcus equi ATCC 33701 Society for General Microbiology - Irish Branch NUI Galway, Ireland, [Details] |
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(2002) | Rhodococcus equi and Equine Rhodococcal Pneumonia Workshop
Duffy, P; O’Connell, E.; Meijer, W. (2002) Using Gene expression profiling to analyse the virulence of Rhodococcus equi Rhodococcus equi and Equine Rhodococcal Pneumonia Workshop Washington State University, Pullman, Washington, USA, [Details] |
Other Journals
Year | Publication | |
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(2017) | 'The reliability of assay-ready plates for cell-based screening enabled by the Echo® 550 Liquid Handler'
Gul, S; Wolf M; O'Connell, E; Fearnhead, H. (2017) 'The reliability of assay-ready plates for cell-based screening enabled by the Echo® 550 Liquid Handler' Drug Target Review, . [Details] |
Abstract
Year | Publication | |
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(2019) | European Conference on Marine Natural Products.
Marchese P, Young R, O’Connell E, Baker B, Johnson M, Fearnhead H, Allcock L, Murphy M (2019) European Conference on Marine Natural Products. Abstract [Details] |
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(2019) | Marine Biotechnology Conference.
Marchese P, Young R, O'Connell E, Baker B, Johnson M, Fearnhead H, Allcock L, Murphy M (2019) Marine Biotechnology Conference. Abstract [Details] |
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(2017) | In Vitro Toxicology Society Annual Meeting.
Tashakor A, H-Dehkordi M, O'Connell E, Hosseinkhani S, Fearnhead H (2017) In Vitro Toxicology Society Annual Meeting. Abstract [Details] |
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(2011) | European Lab Automation Congress.
Monaghan, D; Griffin, R; Regan, A; O’Connell, E; Fearnhead, H (2011) European Lab Automation Congress. Abstract [Details] |
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(2011) | Irish Association for Cancer Research.
Monaghan, D; O’Connell, E; Fearnhead, HO. (2011) Irish Association for Cancer Research. Abstract [Details] |
Honours and Awards
Year | Title | Awarding Body | |
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2022 | Galway Science Person of the Year | Galway Science and Technology Festival | |
2020 | NUI Galway President's Award for Societal Impact | NUI Galway | |
2015 | ALIVE Presidential Award for Volunteering | NUI Galway | |
2014 | Scientific Outreach Award | Biochemical Society | |
2014 | ALIVE Presidential Award for Volunteering | NUI Galway | |
2013 | EXPLORE Innovation Initiative Award | NUI Galway Student's Union | |
2012 | "I'm a Scientist...get me out of here!" zone winner | "I'm a Scientist...get me out of here!" outreach programme | |
2008 | Award in Team Leading | Institute of Leadership and Management | |
2003 | Open Postgraduate Scholarship Award | University College Dublin | |
2000 | Research Scholarship | Enterprise Ireland |
Community Engagement
Title | Type | From / To | |
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Outreach | Founding Director ReelLIFE SCIENCE public engagement programme | 01-MAY-13 / | |
Outreach | Galway Science and Technology Forum | 01-JAN-14 / | |
Outreach | "I’m a Scientist, Get me out of Here", Ireland - Health Zone Winner 2012 | 12-NOV-12 / 23-NOV-12 |
Committees
Committee | Function | From / To | |
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NCBES Safety Management Committee | Member | 01-JAN-17 / 02-MAY-19 | |
STEM Promotion Committee | NCBES Representative | 01-JAN-16 / 23-JAN-20 | |
Galway Science and Technology Forum | NUI Galway Representative | 01-JAN-14 / |
Employment
Employer | Position | From / To | |
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University of Galway | Microarray Technologist | 05-SEP-05 / 18-MAR-08 | |
University of Galway | Senior Technical Officer (Genomics and High Throughput Screening) | 18-MAR-08 / |
Education
Year | Institution | Qualification | Subject | |
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1996 | Garbally College Ballinasloe | Leaving Certificate | Various | |
2000 | University College Dublin | BSc | Industrial Microbiology | |
2009 | University College Dublin | PhD | Regulation of Virulence Gene Expression of the Intracellular Pathogen Rhodococcus equi. |